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131
resultados
Última actualización
04/10/2026 [07:14:00]
Resultados 100 a 125 de 131
Resumen de: CN122427295A
本发明涉及生物技术、动物防疫领域，具体涉及一种α和ε型产气荚膜梭菌的融合蛋白、亚单位疫苗组合物及其应用。本发明通过将产气荚膜梭菌ε蛋白片段、产气荚膜梭菌α蛋白片段、鼠伤寒沙门氏菌鞭毛蛋白片段利用柔性连接肽顺序连接，构建得到了一种无毒力、安全性高、能够有效刺激机体产生抗体的融合蛋白，其氨基酸序列如SEQ ID NO:13所示。该融合蛋白经大量分泌表达后，蛋白含量不低于575μg/mL，蛋白纯度不低于87%。本发明进一步以融合蛋白为抗原，制备得到了一种能够同时预防产气荚膜梭菌α毒素和ε毒素引起的疾病的亚单位疫苗组合物，其制备方法简单、生产成本低，免疫效果好，具有高效的中和与攻毒保护能力，持久免疫应答能力，同时质量稳定、安全性高。
Resumen de: CN122398730A
The invention discloses a preparation method and application of pithecellobium clypearia polyphenol liposome, and belongs to the technical field of traditional Chinese medicine pharmacy. The preparation method of the pithecellobium clypearia polyphenol liposome comprises the following steps: dissolving soybean phospholipid and cholesterol in absolute ethyl alcohol, and then adding pithecellobium clypearia polyphenol. The mass ratio of the soybean phospholipid to the cholesterol is 5: 1. The mass ratio of the soybean phospholipid to the pithecellobium clypearia polyphenol is 15: 1. The encapsulation efficiency of the pithecellobium clypearia polyphenol liposome prepared by the preparation method is 89.31%, the drug loading capacity is 4.61%, and the pithecellobium clypearia polyphenol liposome has good fluidity and stability. The pithecellobium clypearia polyphenol liposome also has the effects of resisting staphylococcus aureus, bacillus subtilis, pseudomonas aeruginosa, escherichia coli and salmonella paratyphi B. The pithecellobium clypearia polyphenol liposome prepared by the invention can achieve the effects of increasing the solubility and improving the bioavailability of pithecellobium clypearia.
Resumen de: CN122404303A
The invention discloses an open-loop clerodane diterpene compound as well as a preparation method and application thereof. The structure of the compound is shown as a formula I, the invention also provides a preparation method of the compound. The preparation method comprises the following steps: carrying out ethanol reflux extraction, solvent extraction, silica gel column chromatography, ODS column chromatography, gel column chromatography, preparative high performance liquid chromatography purification and the like on a sculellaria barbata raw material. An in-vitro antibacterial activity test shows that the compound has a remarkable inhibition effect on human pathogenic bacteria such as enterobacter cloacae, escherichia coli, klebsiella, pseudomonas aeruginosa, salmonella typhimurium and staphylococcus aureus, the minimum inhibition concentration (MIC) is as low as 1-4 mu g/mL, and the effect is superior to or equivalent to that of a positive control drug. The compound disclosed by the invention is novel in structure, stable and controllable in preparation method and excellent in antibacterial activity, can be used as a medical intermediate or an active ingredient of an antibacterial drug, and has a wide application prospect in the fields of medicines, agriculture, daily chemicals and the like.
Resumen de: CN122405448A
The invention provides a freshwater fungus YR183 as well as a metabolite and application thereof, and belongs to the technical field of microorganisms. The preservation number of the freshwater fungus YR183 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.42760. The freshwater fungus YR183 is a new species of the genus Kissleriella, and the freshwater fungus YR183 is named as Kissleriella aquatia, and the freshwater fungus YR183 is named as Kissleriella aquatia. The freshwater fungus YR183 and the secondary metabolite thereof have a good inhibition effect on bacteria. The result of the embodiment shows that when the metabolite of the freshwater fungus YR183 is inoculated into a culture medium coated with bacteria, the growth of staphylococcus aureus, salmonella and shigella can be effectively inhibited. In addition, the extraction method of the secondary metabolite of the freshwater fungus YR183 is simple and convenient to operate, easy to implement, short in period and low in cost, and has a wide market application prospect.
Resumen de: CN122404548A
The invention discloses a monoclonal antibody for detecting surface protein SapA of campylobacter fetus and application of the monoclonal antibody. The monoclonal antibodies are named as 4F6 and 7B3 respectively, and amino acid sequences of variable regions of heavy chains and light chains of the two antibodies are disclosed. The monoclonal antibody prepared by the invention can specifically recognize the surface protein SapA of the campylobacter fetus, has better specificity, and does not have cross reaction with non-campylobacter such as standard escherichia coli, salmonella, listeria, klebsiella pneumoniae, staphylococcus aureus, streptococcus and the like; no cross reaction with campylobacter jejuni, campylobacter colon and other campylobacter is generated; the test strip prepared by combining the monoclonal antibody and colloidal gold can realize on-site rapid detection of the campylobacter fetus, the detection limit is low, the sensitivity is high, and an immunological method capable of specifically detecting the campylobacter fetus is successfully developed.
Resumen de: CN122409630A
The invention discloses a salmonella dual-mode detection method based on medium-temperature Argonaute driving, and belongs to the technical field of food safety detection. According to the method, the functionalized DNA hydrogel internally packaged with an asymmetric RPA system, a CbAgo system and nano-enzyme is constructed, cascade signal amplification, DNA hydrogel phase change and nano-enzyme signal output links are integrated, and rapid detection of salmonella is realized under the assistance of gravity. The invention also independently develops portable detection equipment and an intelligent application program, realizes automatic image acquisition and analysis, has the advantages of high sensitivity, strong specificity and simplicity and convenience in operation, and is suitable for on-site rapid detection of food safety.
Resumen de: CN122405832A
The invention discloses an SV molecular marker closely associated with pullorum disease anti-infection phenotype and application thereof, and belongs to the technical field of molecular breeding. The invention provides an SV molecular marker closely associated with the anti-infection phenotype of salmonella pullorum, and compared with a homozygous salmonella pullorum high-resistance individual, a homozygous salmonella pullorum susceptible individual is 324bp less as shown in SEQ ID NO.1; the invention also provides a pair of primers for amplifying the SV marker, and the sequences of the primers are as shown in SEQ ID NO.2 and SEQ ID NO.3; by adopting the molecular marker and the primer provided by the invention, an individual with high anti-infection capability on salmonella pullorum can be identified or bred in an early stage, a detection result is not influenced by factors such as sex, life habits and environment of chickens, the breeding process can be effectively shortened, the breeding workload can be reduced, and the stability and reliability of the result can be improved; the method has important significance for reducing economic loss of farmers caused by infection of salmonella pullorum.
Resumen de: CN122405564A
The invention discloses a novel salmonella virulence phage vBSalSM6 and a phage cocktail composition of the novel salmonella virulence phage vBSalSM6. The bacteriophage vBSalSM6 has splitting activity on a plurality of serotype salmonella. The bacteriophage cocktail prepared by mixing the bacteriophage vBSalSM6 and the bacteriophage vBVpaPG1 has a cracking rate of 98.11% on 53 strains of salmonella. An in-vivo experiment result shows that the phage cocktail is put into use in a drinking way, the number of salmonella in feces of laying hens can be remarkably reduced, the sterilization rate is 99.59%, growth performance reduction, liver function damage, egg quality reduction and intestinal mucosa damage caused by salmonella infection are improved, and the phage cocktail has no adverse effect on healthy laying hens. The bacteriophage and the cocktail thereof provided by the invention have the characteristics of wide host spectrum, high safety, remarkable antibacterial effect and the like, are suitable for prevention and control of avian salmonella infection, and have a good application prospect.
Resumen de: CN122405482A
The invention provides a lactobacillus plantarum DC76 and application thereof, the strain is separated from the traditional fermented food of Guizhou, is preserved in Guangdong Microbial Culture Collection Center on November 26, 2025, and has a preservation number of GDMCC No.67360. The lactobacillus plantarum DC76 has the advantages that the lactobacillus plantarum DC76 can be used for preparing the lactobacillus plantarum DC76, and the lactobacillus plantarum DC76 can be used for preparing the lactobacillus plantarum DC76; the strain has excellent acid resistance and cholate resistance, and has a remarkable inhibition effect on various animal pathogenic bacteria such as escherichia coli, salmonella, pasteurella and the like; the intestinal microecological balance can be regulated, the expression of tight junction proteins ZO-1 and Occludin in the intestinal tract can be up-regulated, the integrity of the intestinal tract barrier can be enhanced, the permeability of the intestinal tract can be reduced, the damaged intestinal tract barrier can be repaired, the immune microenvironment of the intestinal tract can be regulated, and the inflammatory response can be relieved. The strain can be used for preparing animal feed additives, microecologics and biological leavening agents, and has good application prospects in the fields of healthy breeding of livestock and poultry and resistance replacement.
Resumen de: US20260201361A1
0000 The invention relates to guided nucleases, CRISPR/Cas systems, crRNAs, single gRNAs, vectors, methods and pharmaceutical compositions, for example for targeting sporulating bacteria, or for targeting C difficile, Salmonella, E coli or Streptococcus.
Resumen de: AU2026205168A1
Synthetic binding agents for reducing the fraction of targets that can permeate through mucus and/or freely divide, and methods of reducing mucosal permeation and/or free division of a target using these synthetic binding agents. un u n
Resumen de: WO2026150325A1
A pharmaceutical combination and uses thereof, wherein the pharmaceutical combination comprises a tumor-homing bacteria and a host-transient bacterial adjuvant comprising a supplementary dose of an immunostimulant.
Resumen de: US20260200994A1
This application relates to compositions and methods used to treat animals with at least one microbial protein, such as a flagellin protein. In embodiments, application relates to compositions and methods to treat animals with a fusion protein comprising at least one adjuvant protein, such as a flagellin protein. In embodiments, the composition further includes at least one adjuvantic protein fused with at least one antigen protein, and the fusion protein is expressed in diatoms.
Resumen de: CN122382226A
The invention discloses a salmonella detection system based on RPA-CRISPRCas12a and application of the salmonella detection system. The detection system comprises an RPA (recombinase polymerase amplification) primer pair, a probe, crRNA (ribonucleic acid) and LbCas12a protein, the sequences of the RPA amplification primer pair are as shown in SEQ ID NO. 1 and SEQ ID NO. 2; the sequence of the probe is as shown in SEQ ID NO.7; and the sequence of the crRNA is as shown in SEQ ID NO. 8. The RPA-CRISPR/Cas12a visual detection system has the advantages of high sensitivity, strong specificity, simplicity and convenience in operation, rapidness in detection and the like, the lowest detection limit of salmonella reaches 1 fg/mu L, and stable and repeatable fluorescence signals and visual results can still be generated under the concentration. The system effectively overcomes the defects of a traditional detection method, is suitable for on-site rapid screening and risk early warning of salmonella in a food chain, provides technical support for food safety supervision, and also provides a reference technical scheme for rapid detection of other food-borne pathogenic bacteria.
Resumen de: CN122381156A
The invention relates to the field of machine learning and prokaryotic expression, and particularly discloses preparation and application of a BamA targeted antibacterial peptide. The novel antibacterial peptide AMP.05 is screened by taking molecular docking and molecular dynamics simulation as technical supports and taking gram-negative bacterium outer membrane protein BamA as a target spot according to physicochemical property indexes of an antibacterial peptide sequence; the method comprises the following steps: constructing a recombinant expression vector pET-28a-AMP.05 by using a genetic engineering technology, and inducing, purifying and separating high-concentration protein; the antibacterial peptide AMP.05 disclosed by the invention has antibacterial activity on escherichia coli (E. coli ATCC 35401, E. coli ATCC 25922 and E. coli BNCC 125783), staphylococcus aureus (S. aureus ATCC 6538), salmonella (S. typhimurium ATCC 14028) and a wild type strain AE81, and the antibacterial peptide AMP.05 disclosed by the invention has the advantages that the antibacterial activity of the antibacterial peptide AMP.05 on the escherichia coli (E. coli ATCC 35401, the E. coli ATCC 25922 and the E. coli BNCC 125783) is improved; the targeted antibacterial peptide AMP.05 screened based on molecular dynamics simulation disclosed by the invention is expected to replace or reduce the use of antibiotics for livestock, and becomes a safe and green ideal antibacterial agent.
Resumen de: CN122382105A
The invention discloses recombinant bacillus subtilis secreting hermetia illucens antibacterial peptide HiUP-6630 for preventing and treating bacterial diseases of ricefield eels, and belongs to the technical field of genetic engineering. The method comprises the following steps: cloning a hermetia illucens HiUP-6630 gene coding region to a bacillus subtilis expression vector pHT43 by utilizing a seamless cloning method, converting a recombinant strain into bacillus subtilis WB800N, screening to obtain positive clone, and inducing by utilizing IPTG (isopropyl-beta-d-thiogalactoside) to obtain the recombinant strain for efficiently expressing the HiUP-6630 protein. The recombinant strain significantly inhibits the growth of escherichia coli, salmonella, listeria monocytogenes, aeromonas sobria and aeromonas veronii. As a water body purification microorganism, the recombinant bacterium can significantly reduce the morbidity of the ricefield eel infected with aeromonas sobria and aeromonas veronii.
Resumen de: CN122381152A
The invention discloses an antibacterial peptide based on a generative artificial intelligence framework targeted gram-negative bacterium de novo design and application thereof, and belongs to the technical field of artificial intelligence and biology. The novel antibacterial peptide which is targeted to gram-negative bacteria and has good antibacterial activity is successfully obtained through directed design of a generative artificial intelligence framework. Experiments prove that the antibacterial peptide MTAMP003 has good antibacterial ability to escherichia coli (E. coli), salmonella typhimurium (S. typhimurium), pseudomonas aeruginosa (P. aeruginosa) and acinetobacter baumannii (A. baumannii), shows low cytotoxicity to human gastric mucosal epithelium, shows low hemolysis to rabbit red blood cells, and shows good application prospect and research value.
Resumen de: CN122382222A
The invention discloses a method for rapidly detecting streptococcus suis or/and salmonella based on an RAA-EXO technology and application of the method. According to the method, specific RAA primers and EXO probes are designed and screened aiming at streptococcus suis recN genes and salmonella invA genes, the sequences of the specific RAA primers and the EXO probes are shown as SEQ ID NO.3, 5 and 10 and SEQ ID NO.14, 15 and 20 respectively, a single or double RAA-EXO detection system for the streptococcus suis and the salmonella is established, detection can be completed within 20 minutes under the condition of the constant temperature of 39-41 DEG C, and the detection sensitivity is high. And no cross reaction with common bacteria such as escherichia coli, staphylococcus aureus and the like exists. Results can be visually judged through a fluorescence curve or a blue light instrument, an effective tool is provided for rapid, sensitive and on-site detection of streptococcus suis and salmonella, and the kit has important application value in the fields of food safety and epidemic disease prevention and control.
Resumen de: CN122356274A
The invention relates to the field of biological medicine, in particular to an O45 Escherichia coli detection antibody and an application method thereof. The antibody is a monoclonal antibody or an antigen binding fragment thereof, and comprises a heavy chain CDR sequence as shown in SEQ ID NO: 1-3 and a light chain CDR sequence as shown in SEQ ID NO: 4-6. The invention also provides a nucleic acid molecule for coding the antibody, an expression vector, a host cell and a preparation method thereof. Specific identification results show that the antibody is specifically combined with O45 Escherichia coli, has no cross reaction with O157, O26, O103, O111, O121, O145 and other Escherichia coli serotypes and O55 related serotypes, and also has no cross reaction with common food-borne pathogenic bacteria. The detection limit of an indirect ELISA detection method established based on the antibody to O45 Escherichia coli can reach 1 * 10 < 2 > CFU/mL, and the whole detection process can be completed within 24 hours. The monoclonal antibody provided by the invention can be applied to preparation of detection kits, detection test paper and other products, and is suitable for rapid screening of O45 Escherichia coli in import and export food.
Resumen de: CN122357356A
The invention provides pediococcus acidilactici M4 for low-moisture fermented feed and application of the pediococcus acidilactici M4, and belongs to the technical field of microorganism application and feed. The fermented total mixed ration is prepared by utilizing pediococcus acidilactici M4. The strain has the characteristics of high permeability, fast acid production and the like, and can reduce the pH value of a fermentation system in a short time; a very strong broad-spectrum bacteriostatic effect is achieved on escherichia coli, salmonella pullorum and staphylococcus aureus; and the method is perfectly suitable for fermentation of low-moisture total mixed ration. As a low-moisture total mixed ration fermentation strain, the strain can significantly reduce the content of acid detergent fibers and neutral detergent fibers and improve the crude protein level, so that the digestibility of the ration is improved, the content of probiotics such as lactic acid bacteria and saccharomycetes in the ration is improved, the content of pathogenic bacteria such as escherichia coli in the ration is reduced, and the content of the low-moisture total mixed ration is improved. Meanwhile, the content of volatile fatty acid in daily ration can be improved, the quality of the daily ration is improved, and the feeding value of the daily ration is improved.
Resumen de: CN122356310A
The invention discloses a recombinant protein for preventing klebsiella pneumoniae as well as a gene and application thereof. The recombinant protein comprises specific antigen epitopes of a klebsiella pneumoniae OmpA protein and/or OmpX protein; the amino acid sequence of the specific antigen epitope of the klebsiella pneumoniae OmpA protein is as shown in SEQ ID NO. 1, and the amino acid sequence of the specific antigen epitope of the klebsiella pneumoniae OmpX protein is as shown in SEQ ID NO. 2. The recombinant protein can be efficiently expressed in a prokaryotic system, and has good immunogenicity after being purified and renatured. Animal experiments show that the recombinant protein can induce mice to generate high-titer specific antibodies and cellular immune responses and provide significant protection against attack of klebsiella pneumoniae with a lethal dose, and the single-component proteins KP-A and KP-X show higher protection rates in a challenge experiment. The recombinant protein provided by the invention can be used for preparing vaccines or immune preparations for preventing and/or treating klebsiella pneumoniae infection.
Resumen de: CN122350172A
The invention discloses a preparation method and a use method of an eggshell antibacterial fresh-keeping additive, and belongs to the technical field of storage and fresh keeping of agricultural products. The additive is prepared by taking natural egg shells as a core raw material through the working procedures of low-temperature crushing, gradient acidolysis, nanometer grinding, compound modification, vacuum freeze drying and the like, and bacteriostatic fresh-keeping particles with porous structures are formed. The additive can be applied to the surface of a fresh egg in a spraying, dipping or embedding mode, a compact protective film is formed on the surface of an eggshell, growth of common pathogenic bacteria such as salmonella and escherichia coli is remarkably inhibited, meanwhile, the microenvironment humidity of the surface of the eggshell is adjusted, evaporation and escape of water in the egg are delayed, and the freshness of an egg product is effectively maintained. The invention has the advantages of wide raw material source, low cost, green and environment-friendly preparation process and no chemical residue risk, can obviously prolong the shelf life of eggs, and is suitable for large-scale storage and circulation links of eggs.
Resumen de: CN122357748A
The invention provides a method for monitoring and evaluating the spreading risk of pathogenic bacteria in excrement of a poultry farm, and belongs to the technical field of biological safety prevention and control of livestock and poultry breeding. The method for monitoring and evaluating the spreading risk of the poultry farm excrement pathogenic bacteria comprises the following steps: evaluating the spreading risk of salmonella in the poultry physiological cycle, evaluating the drug resistance early warning risk associated with the drug administration behavior, and monitoring the function in the composting process based on flora structure monitoring and metabolic function monitoring. According to the method, the highest risk node of pathogenic bacteria pollution and drug resistance evolution in the breeding period can be accurately positioned, the problem of inaccurate risk source identification in the prior art is solved, and poultry product pollution caused by risk missed judgment is avoided; according to the method, the single-dimension limitation that only the number of pathogenic bacteria is detected in the prior art is broken through, the risk of the pathogenic bacteria is comprehensively evaluated from the three aspects of phenotype, molecule and function, the judgment result better meets the biological safety requirement of actual breeding, and finally the safety risk of poultry product pollution and antibiotic drug resistance diffusion can be reduced.
Resumen de: CN122351451A
本发明提供了一种预防幽门螺杆菌感染的组合物及制备方法和应用。所述组合物包括外膜囊泡混合物和嗜黏蛋白阿克曼氏菌菌液；所述外膜囊泡混合物由沙门菌突变株QS0074的外膜囊泡和大肠杆菌E. coli Nissle 1917的外膜囊泡按照重量比2:1组成；所述外膜囊泡混合物和嗜黏蛋白阿克曼氏菌菌液的重量体积比为1mg:1mL。本发明所得组合物在攻毒试验中，显著优于对照组，具有高效的预防幽门螺杆菌感染的效果。同时，本发明的组合物各组分之间在诱导小鼠产生分泌性IgA水平和分泌性IgA水平以及诱导小鼠产生抵抗幽门螺杆菌感染能力方面，均产生了明显的协同作用，具有良好的应用前景。
Nº publicación: CN122357458A 10/07/2026
Solicitante:
QINGDAO RUNDA BIOTECHNOLOGY CO LTD
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Resumen de: CN122357458A
The invention relates to the technical field of microorganisms, in particular to a broad-spectrum cleavage salmonella salmonella bacteriophage, a composition and application. The bacteriophage is preserved in the China General Microbiological Culture Collection Center, and the preservation number is CGMCC No. 45281. The bacteriophage is separated by taking a strain of Salmonella Sanpora as a host, and has the core advantages that (1) the bacteriophage has extended-spectrum lysis activity and can efficiently lyse at least 11 important salmonella serotypes such as salmonella enteritidis and salmonella typhimurium; (2) the catalyst has excellent physical and chemical stability, and can still keep high activity after being treated for 1 hour under the conditions that the pH is 4-11 and the temperature is 60 DEG C; based on the characteristics, the invention also provides a composition containing the bacteriophage, and application of the bacteriophage in preparation of products for disinfection and preservation of food surfaces and prevention and treatment of salmonella infection of livestock and poultry. The bacteriophage solves the problems of narrow host spectrum, poor stability and single application scene of the bacteriophage in the prior art.
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