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具有改进的SLS 3D打印烧结性能的聚己内酯

Resumen de: WO2025073518A1

The present invention refers to a compound particle for 3D printing obtained by hot melt extruding 50 to 90 wt.-% at least one polycaprolactone based polymer; 10 to 50 wt.-% of at least one filler; and optionally up to 5 wt.-% of at least one additive into pellets, wherein the total weight of the components is 100 wt.-%, and thereafter milling the pellets to obtain the compound particle. Furthermore, the present invention refers to a composition for 3D printing comprising a) 94 to 99 wt.-% of at least one compound particle according to the present invention; b) 1 to 6 wt.-% of at least one filler; and c) optionally up to 5 wt.-% of at least one additive; wherein the total weight of a) to c) is 100 wt.-%. Moreover, the present invention refers to a 3D printing method comprising the compound particle or the composition according to the present invention, the article obtained by the 3D printing method and its use as a substitute for bones or a scaffold for broken bones.

一种负压产生装置

Resumen de: CN224180017U

本实用新型公开了一种负压产生装置，该装置包括本体和连接于本体的握持部，本体顶端设有开口，本体底端设有多个通孔，开口和通孔之间连接壁面，使壁面内由开口至通孔形成腔体；本体还设有：控制模块，控制模块设于壁面外；料仓，料仓为无顶盖的筒状结构；筒底部设有若干小孔；料仓上设有升降模块，所述升降模块连接驱动机构以使料仓在腔体内进行上升或下降；驱动机构连接控制模块；握持部两端开口，一端连通于本体的底端，另一端为负压作用口。本实用新型的负压产生装置结构简单，使用方便，该装置底部的负压作用口可精准适配身体各个部位，用于在身体部位产生负压。通过控制模块对升降模块的位移，使料仓靠近或远离负压作用口，实现负压作用口附近的自动控温。

一种可光固化Matrigel基质胶的生物墨水、制备方法及在体积生物打印中的应用

Resumen de: CN121944242A

本发明属于生物打印技术领域，具体公开了可光固化Matrigel基质胶的生物墨水、制备方法及在体积生物打印中的应用，该生物墨水由水凝胶和Matrigel基质胶混合后加入光引发剂制成，能在光源的照射下实现可控固化，解决了现有技术中Matrigel基质胶缺乏光敏基团导致无法进行光交联反应的问题，本发明还通过将该生物墨水与生物介质混合，得到了复合生物墨水并与GLVBP技术完美兼容，打印成型的结构具有高精度、高细胞活性及良好的生物相容性，在类器官培养、组织工程等生物医学领域具有广阔的应用前景。

基于3D打印的仿生椎间盘一体化类器官及其构建方法与应用

Resumen de: CN121950678A

本发明公开了基于3D打印的仿生椎间盘一体化类器官及其构建方法与应用，涉及生物医学工程领域。该构建方法包括以下步骤：采用聚合物材料通过3D打印制备交叉网状仿生支架，经卷曲成型为圆柱状纤维环结构，得到纤维环仿生支架；将多能干细胞经中胚层诱导后，分别进行软骨诱导和纤维软骨诱导，获得类髓核的软骨类器官与类纤维环的纤维软骨类器官；将该软骨类器官置于该纤维环仿生支架的中心，该纤维软骨类器官填充于该纤维环仿生支架的网格结构中，经基质胶包裹和孵育固化后，经诱导培养得到该基于3D打印的仿生椎间盘一体化类器官。本发明提供的基于3D打印的仿生椎间盘一体化类器官，能够有效复现天然椎间盘的结构特征与功能特性。

一种3D打印用齿科TC4/TAl混合粉末及其制备方法

Resumen de: CN121943677A

本申请涉及齿科材料的技术领域，具体公开了一种3D打印用齿科TC4/TAl混合粉末及其制备方法。3D打印用齿科TC4/TAl混合粉末的化学成分如下，Al：2.75‑4.75wt.%，V：1.75‑3.25wt.%，Ti余量。其制备方法包括如下步骤：将TC4粉末和TAl粉末分别过筛，得到符合要求的备用TC4粉末和备用TAl粉末；在惰性气体保护下，按配比混合，真空干燥、过筛后，得到3D打印用齿科TC4/TAl混合粉末。本申请可以获得化学成分均匀、流动性好的粉末，而且成型样件的强度和韧性的平衡更优异，更适用于3D打印工艺制作齿科修复体。

一种下颌髁突固定板组件及制作方法

Resumen de: CN121943445A

本发明公开了一种下颌髁突固定板组件及制作方法，下颌髁突固定板组件设置在骨折块和下颌骨本体上，下颌髁突固定板组件包括：第一固定板，分别连接骨折块和下颌骨本体；第二固定板，分别连接骨折块和下颌骨本体；第一固定板和第二固定板活动连接；第一固定板上设置有第一防滑部，第二固定板上设置有第二防滑部。本发明的有益效果是：通过第一固定板和第二固定板的活动连接，以将骨折块的空间位置进行精确定位及固定，替代“徒手复位” 的经验依赖，实现术中 “连接即复位” 的精准操作，降低术后咬合紊乱、颞下颌关节功能障碍等并发症的发生率。在第一固定板和第二固定板分别设置第一防滑部和第二防滑部，以增加骨‑板摩擦力，从而防止骨折块移位。

一种具有递进式变化孔隙率的三层人工软组织修复膜

Resumen de: CN121943521A

本发明公开了生物医学组织工程领域的一种具有递进式变化孔隙率的三层人工软组织修复膜，该修复膜由内向外依次包括有序纤维层、螺旋无序纤维层和有序纤维层，形成孔隙率递进增大的结构。各层采用生物可降解材料制成，可选自多种天然或合成聚合物。纤维直径在纳米级至微米级范围，有序纤维层的纤维间距可调且由内向外递增。该膜可负载多种生物活性物质与药物，其表面也可用生长因子或纳米材料等修饰。制备方法主要采用近场直写3D打印工艺，通过调控打印参数实现。所得修复膜孔隙结构独特，能模拟天然组织，促进细胞有序生长与组织修复，适用于组织工程支架领域。

SYSTEMS AND METHODS FOR PREDICTING PERIODONTAL POCKET DEPTH AND/OR OTHER INTRAORAL CONDITIONS

Resumen de: US20260114972A1

Systems and methods for evaluating a patient's intraoral health are provided. In some embodiments, a method includes receiving scan data of a patient's intraoral cavity; receiving additional data for the patient, the additional data being different from the scan data; determining a first prediction of a condition of the intraoral cavity based on the scan data; determining a second prediction of a condition of the intraoral cavity based on the additional data; generating a predicted condition for the intraoral cavity based on a combination of the first and second predictions; and outputting an indication of the predicted condition on a display.

REPOSITION AND PENETRATION FORCEPS AND EXTERNAL FIXATOR FOR FRACTURES OF LONG BONES

Resumen de: US20260114904A1

Reposition and penetration forceps for fractures of long bones, in particular traumatic fractures of tibia in centre line, that comprise two jaws forming a three-point system in opposition, wherein the first movable jaw (1) comprises two threaded pins (7) with tips (21) and the second firm jaw (2) comprises one threaded pin (7) with a tip (21). An external fixator for fractures of long bones, in particular traumatic fractures of tibia in centre line, which comprises at least two sets of forceps, wherein the sets of forceps are arranged identically or in a mirror image to each other.

VERFAHREN ZUR HERSTELLUNG FLÄCHIGER, PORÖSER HYDROGELE MITTELS FLUSS-LITHOGRAPHIE

Resumen de: DE102024131256A1

Die vorliegende Erfindung liegt im technischen Gebiet der additiven Fertigung und stellt ein kontinuierliches Verfahren zum Herstellen von flächigen, porösen Hydrogelen und Strukturen bereit. Ebenfalls stellt die vorliegende Erfindung eine Vorrichtung zur kontinuierlichen Herstellung von Hydrogelen bereit.

MEDICATION CONTAINER AND INFUSION SYSTEM HAVING SUCH A MEDICATION CONTAINER

Resumen de: US20260115377A1

0000 Medication container for use in infusion therapy and an infusion system incorporating such a medication container. Medication containers often flexible medication bags. The a medication container has a wall, which encloses an interior. A liquid to be administered to a patient can be held in this interior. The medication container also comprises at least one fluid coupling for connecting a fluid line for taking liquid from the medication container. The medication container comprises a first transmission device, wherein the first transmission device is configured for data communication with an information carrier applied on an outer side of a wall of the medication container.

VISION SCREENING SYSTEMS AND METHODS

Resumen de: US20260114727A1

A system includes system housing, an eccentric radiation source, and a radiation sensor. The radiation produced by the eccentric radiation source can be collected by the radiation sensor to generate images of retinas for a patient. The system also includes a vision screening device connected with the eccentric radiation source and the radiation sensor via the system house that can control and synchronize actions for the eccentric radiation source and the radiation sensor. The vision screening device further analyzes the images generated by the radiation sensor via neural network algorithms to determine spherical error slopes, refractive errors, and recommendations for the patient.

Infused Particles

Resumen de: US20260114749A1

0000 A method of making infused bone particles employs the following steps: cutting or shaving whole bone into bone particles, washing the bone particles, demineralizing or decalcifying at least partially the whole bone or bone particles and infusing the bone particles with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused bone particles. The step of infusing includes exposing the bone particles to a negative pressure or vacuum to draw the supernatant and/or the polyampholyte cryoprotectant into the bone particles, or alternatively, exposing the demineralized whole bone to a positive pressure to drive the supernatant and/or the polyampholyte cryoprotectant into the bone. The resultant method creates an infused bone grafting composition having bone particles taken from whole bone, demineralized or decalcified at least partially and infused with one or more of a supernatant of biologic material or a polyampholyte cryoprotectant or both.

THERMAL FIELD SCANNER

Resumen de: US20260114735A1

0000 A measurement device can be used by a patient or user to scan a tissue site to generate a thermal image of the scanned tissue site. The device can measure and collect temperature data and position data using one or more thermal and position sensors. The data can be used to generate a thermal image of the scanned tissue. The thermal image can be used to monitor various tissue sites and determine location and severity of inflammation. The thermal field scanner can help patients in avoiding formation of ulcers and other dangerous medical conditions.

Systems and Methods for Immobilizing Extracellular Matrix Material on Organ on Chip, Multilayer Microfluidics Microdevices, and Three-Dimensional Cell Culture Systems

Resumen de: US20260117154A1

0000 The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.

SYSTEMS AND METHODS FOR MANAGING GLYCEMIC VARIABILITY

Resumen de: US20260120863A1

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

BIOENGINEERING MUSCLE CONSTRUCTS USING 3D PRINTED MICRO- AND ULTRA-FINE FIBERS

Resumen de: US20260115355A1

0000 Provided are ultrafine-fiber or microfiber scaffolds including a plurality of wall fibers and a plurality of reinforcing fibers, each reinforcing fiber including at least two (such as at least four) anchor segments and at least one (such as at least three) bridge segment, wherein: the wall fibers and the anchor segments are substantially aligned forming a plurality of walls, and the bridge segments each extend across the space between any two adjacent walls. Further provided are methods of producing an ultrafine-fiber or microfiber scaffold by electrohydrodynamic printing (EHD), including jetting along a first straight jetting path that is offset relative to the wall fiber direction at angle of less than 90°. Also provided are methods of culturing cells, forming tissues, and treating an injury using the disclosed scaffolds and compositions.

BIOCOMPATIBLE, ELECTRICALLY CONDUCTING HYDROGELS, PREPARATION AND USE THEREOF

Resumen de: WO2026087490A1

The invention relates to biocompatible electrically conducting and preferably optically transparent hydrogels, to a 3D printing method of forming such biocompatible electrically conducting and/or optically transparent hydrogels, to a method for developing functional cell networks from human induced pluripotent stem cells, to a 3D bioelectric platform comprising said 3D-printed biocompatible electrically conducting and/or optically transparent hydrogels and a method of creating the same, and to the use of said hydrogels.

METHOD, DEVICE, AND SYSTEM FOR TRACKING MEDICATIONS

Resumen de: US20260115101A1

0000 A method of tracking medications to be administered includes assigning, in a computing device, a medication to a slot in a cart insert for a medication cart. Medication tracking data is recorded in a database for the location of that medication and the identity of an individual to whom the medication is to be administered. The cart insert with the medications packed therein is loaded into a medication cart. A computing device retrieves the medication tracking data from the database, and upon selection in a computing device of the individual and medication to be administered, the computing device identifies the location of the medication in the cart by illuminating lights on the front of the drawer of the cart at which the medication is located, and lights adjacent a row and a column of slots at the intersection of which is found the slot containing the selected medication.

PERMEABLE BARRIER TO ENHANCE REGENERATION AT TISSUE INTERFACES AND THERAPEUTIC METHODS OF USE THEREOF

Resumen de: WO2026090254A1

Systems, methods, and compositions directed to the engineered incorporation of a tidemark-mimetic into a 3D printed osteochondral (OC)-mimetic hydrogel scaffold configured to recapitulate a mineralized barrier that restricts transport of calcifying ions into the articular (hyaline) cartilage layer, and/or an engineered cement line-mimetic configured to prevent cellular migration from the subchondral bone layer into the cartilage layers.

DEVICE FOR MONITORING AND CORRECTING THE CONVERGENCE ANGLE OF THE WALLS OF PREPARED TEETH

Resumen de: WO2026089594A1

The present device pertains to the field of medicine, and more particularly to orthopaedic dentistry, and can be used for ensuring precision in the tooth preparation step during the installation of prostheses. The claimed device comprises a 1:5 red band micromotor or turbine handpiece, a coupling, an abrasive tool, two levers, a template, a pivoting assembly, a flange, a bushing, a bracket, and a shaft, wherein the flange is secured in the template, which is printed on a 3D printer, and the pivoting assembly is comprised of linear slide bearings and a guide shaft, wherein the shaft and the bracket are parallel to one another, and the handpiece is fastened by the coupling such that the axis of the abrasive tool is parallel to the axis of the shaft. The device provides a broader range of use in the given field of orthopaedic dentistry than the existing prior art.

MULTIPHASIC MICROFLUIDIC METHOD FOR ADAPTIVE MULTI-MATERIAL 3D PRINTING

Resumen de: US20260115998A1

Stereolithography (SLA)-based 3D printing enables high-resolution microfabrication but faces challenges in multi-material integration and adaptive Z-layer control due to reliance on vats and mechanical stages. We introduce “In-situ 3D Polymerization” (IS-3DP), a novel method leveraging multiphasic laminar flow in a microfluidic channel to fabricate three-dimensional microstructures. By combining in-situ polymerization with an aqueous two-phase system (ATPS), IS-3DP dynamically controls layer thickness through flow rate adjustments, achieving resolutions below 200 μm. This approach eliminates vats, reducing material consumption by an order of magnitude, and enables rapid multi-material switching without complex printer modifications. Compatible with various light sources and photopolymers, IS-3DP offers versatile applications in bioprinting and microdevice manufacturing, with demonstrated layer-by-layer printing of 3D structures in a microfluidic environment.

Laser Methods and Systems for Addressing Conditions of the Lens

Resumen de: US20260115045A1

Systems and methods for performing laser cataract surgery, for using a biometric system to determine a material property of a structure of the eye, laser pulses in a laser shot pattern having different powers. A therapeutic laser, and laser delivery system having the capability to vary the power of the laser beam.

Eyewear with Eating-Activated Camera for Monitoring Food Consumption

Resumen de: US20260120843A1

0000 A wearable device or system for monitoring food consumption can include a wrist-worn or finger-worn device which is worn by a person, a motion sensor on the wrist-worn or finger-worn device, eyewear which is worn by the person, and a camera on the eyewear which is activated to record food images when analysis of data from the motion sensor detects that the person is eating. This device can be used alone or as part of a closed-loop glucose level management system.

NEUROLOGICAL STATE, DISEASE, DYSFUNCTION, OR INJURY IDENTIFICATION SYSTEMS AND DEVICES

Nº publicación: US20260114815A1 30/04/2026

Solicitante:

BRAINSCOPE COMPANY INC [US]
BrainScope Company, Inc.

Resumen de: US20260114815A1

0000 Subject measurement systems can generate indications of neurological state, disease, dysfunction, or injury using a machine learning model. The machine learning model can include at least one encoding model and a sequential model pre-trained to perform language processing tasks. The machine learning model can further include a classifier configured to output classifications. The at least one encoding model, sequential model, and at least one decoding model can be jointly trained to predict timeseries output, thereby adapting the pre-trained sequential model for use with neurologically relevant input domains, such as medical images, EEG data, evoked response data, speech data, or the like. The at least one encoding model, sequential model, and classifier can be jointly trained to output indications of neurological state, disease, dysfunction, or injury. A subject measurement system can then generate such indications using patient data and the at least one encoding model, sequential model, and classifier.