Requisitos

ＡＰＩ装填組織貫通器を介して薬物を送達するためのデバイス及び方法

Resumen de: CN120641167A

A drug delivery device comprises at least one tissue penetrating member configured to be embedded in tissue, the at least one tissue penetrating member comprising: a plurality of lumens, and at least one payload comprising at least one active pharmaceutical ingredient (API) loaded into the plurality of lumens, the at least one tissue penetrating member is configured such that when the at least one tissue penetrating member is embedded in the tissue, the at least one API can be absorbed into the tissue wherein a ratio of a surface area of the plurality of lumens to a volume of the plurality of lumens is at least 0.5: 1.

SUPRASTRUCTURE, DENTAL PROSTHESIS, AND METHOD FOR PRODUCING A DENTAL PROSTHESIS

Resumen de: WO2026022080A1

The invention relates to a suprastructure (14) for a dental prosthesis (10), comprising: a tooth-crown main body (24) which carries at least one artificial tooth crown; a positioning body (26) having a through-opening for receiving a fastening means (16) for indirectly or directly fastening the suprastructure (14) to a dental implant (12); and a coupling device which captively couples the positioning body (26) to the tooth-crown main body (24) and is designed to allow for a relative movement of the positioning body (26) relative to the tooth-crown main body (24).

METHOD OF MANUFACTURING A BIORESORBABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE USING A 3D PRINTER AND BIORESORBABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE

Resumen de: WO2026022121A1

A method of manufacturing a bioresorbable polymeric intravascular tubular device using a 3D printer and a bioresorbable polymeric intravascular tubular device are provided. The method comprises patterning a linear micropattern design comprising different periodicities ranging from 3 μm to 32 μm and a given depth onto a surface of a steel rod; dispensing, while the steel rod is rotating, a polymer-based ink on the generated linear micropattern using a nozzle of a 3D printer; and obtaining a bioresorbable intravascular device with an inner biomimetic topography through solidification of the polymer-based ink.

TRANSALVEOLAR DENTAL IMPLANT AND METHOD OF MANUFACTURE

Resumen de: EP4659703A2

The present disclosure relates to single tooth or full arch dental restoration. In cases where patients have insufficient bone stock for conventional root-form dental implants, current solutions often fail to restore function. The present disclosure describes a transalveolar dental implant for single tooth or full arch dental restoration. The transalveolar dental implant is comprised of a post and a bone plate, the bone plate having a contoured portion fabricated to match the topography of a bony surface of the facial skeleton. Through primary fixation of the contoured portion of the bone plate, the transalveolar dental implant improves function and outcomes in affected patients.

METHOD OF MANUFACTURING A BIODEGRADABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE USING A 3D PRINTER AND BIODEGRADABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE

Resumen de: EP4684765A1

A method of manufacturing a biodegradable polymeric intravascular tubular device using a 3D printer and a biodegradable polymeric intravascular tubular device are provided. The method comprises patterning a linear micropattern design comprising different periodicities ranging from 3 µm to 32 µm and a given depth onto a surface of a steel rod; dispensing, while the steel rod is rotating, a polymer-based ink on the generated linear micropattern using a nozzle of a 3D printer; and obtaining a biodegradable intravascular device with an inner biomimetic topography through solidification of the polymer-based ink.

POST-PROCESSING OF BIOLOGICAL SCAFFOLDS

Resumen de: AU2024238878A1

A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.

PERIODONTAL TISSUE REGENERATION MATERIAL

Resumen de: EP4685229A1

There is a demand for establishing a technique for realizing tissue regeneration even in cases of severe periodontal tissue loss. The present invention provides a periodontal tissue regeneration material for grafting, which contains graft tissue containing mesenchymal stem cells and collagen secreted from the mesenchymal stem cells. The graft tissue each include 2 × 10⁵ or more cells, and have a projected area equivalent circle diameter or a thickness of 1 mm or more.

3D PRINTING INK COMPOSITION AND 3D PRINTING MOLDED ARTICLE FORMED BY CURING SAME

Resumen de: EP4684812A1

The present invention relates to a 3D printing ink composition including a pluronic copolymer, an acrylamide monomer, an alkali metal salt and a solvent, and a 3D printing molded article formed by curing the ink composition.

NERVE GRAFTS FOR PERIPHERAL NERVE REGENERATION

Resumen de: US2024342342A1

The present disclosure generally relates to nerve grafts (e.g., allografts), particularly to methods of preparing immunologically anonymized nerve segments and methods of preparing personalized nerve grafts. The present disclosure also provides methods of regenerating a nerve defect.

腱/韧带骨结合处特殊骨小梁区力学生物学双向仿生的骨生物结构制备方法及系统

Resumen de: CN121401512A

本发明公开了一种腱/韧带骨结合处特殊骨小梁区力学生物学双向仿生的骨生物结构制备方法及系统，属于骨生物材料制备技术领域，包括：基于目标区域的人体标本切片提取骨小梁的形态学信息和腱/韧带骨结合处力学参数；基于骨小梁的形态学信息确定仿生结构；基于腱/韧带骨结合处力学参数确定制备仿生结构的生物材料；基于仿生的结构和骨生物材料制备仿生骨生物结构；对仿生骨生物结构表面进行改性处理，得到最终的仿生骨生物结构。本发明将腱/韧带骨结合处骨小梁的构筑信息与3D打印技术结合，实现腱/韧带骨结合处重建时，植入物的结构与材料协同仿生，为腱/韧带骨结合处研发具有更好生物相容性的骨生物结构提供了重要技术支持。

预成冠的生物陶瓷增材光固化成型方法和预成冠

Resumen de: CN121401483A

本申请公开了一种预成冠的生物陶瓷增材光固化成型方法和预成冠。方法包括：制备液态打印材料，所述液态打印材料包括以下组分：液态的聚甲基丙烯酸甲酯、纳米级氧化锆颗粒、纳米级二氧化硅颗粒和光敏引发剂；利用光固化3D打印机对所述液态打印材料进行面投影光固化打印，打印过程中通过从底部向上投射的光源进行逐层曝光，使所述液态打印材料沿垂直方向固化成型，致使所述聚甲基丙烯酸甲酯固化后的微观结构包括密集分布的纳米级柱状单元，所述纳米氧化锆颗粒和所述纳米二氧化硅颗粒分散于所述纳米级柱状单元内部；打印完成后去除支撑结构，并进行抛光处理，得到成型的预成冠。本申请可以解决现有技术因存在高温烧结环节而导致的诸多问题。

喷墨墨水

Resumen de: TW202506911A

Provided is an inkjet ink which is excellent in terms of drying after printing, initial dot ejection, storage stability, and continuous printability and does not bleed after printing, in order to provide an inkjet ink that does not require an ink circulation mechanism while using an alcohol such as ethanol as a solvent for printing on non-permeable tablets. The inkjet ink is used for printing with a non-circulation type printer, and contains an organic acid monoglyceride and an alcohol. An organic acid constituting the organic acid monoglyceride has 2-10 carbon atoms.

一种用于增材制造的医用Ta-xTi合金高品质粉体及其制备方法

Resumen de: CN121402638A

本发明属于生物医用金属材料领域，公开了一种用于增材制造的医用Ta‑xTi合金高品质粉体及其制备方法，该粉体由钛粉、钽粉、钽掺杂氮化钛包覆非晶碳纳米壳与钇稳定氧化锆包覆介孔二氧化硅纳米颗粒及硬脂酸按特定重量份配比组成。制备过程首先通过静电自组装技术在微米级钛粉表面均匀吸附纳米钽粉与两种改性化合物，形成核壳结构复合粉体；随后利用射频等离子体对该复合粉体进行球化处理，最终获得球形度高、流动性好的高品质合金粉体。该方法解决了高熔点钽与钛在激光选区熔化成形过程中的成分偏析与未熔颗粒问题，同时赋予材料更低的弹性模量和增强的生物活性与抗菌性能，特别适用于制造高性能定制化骨植入体。

一种双层后巩膜加固生物材料及其制备方法和用途

Resumen de: CN121401499A

本申请公开了一种双层后巩膜加固生物材料及其制备方法和用途。本申请的双层后巩膜加固生物材料，包括外加固层和水凝胶内层；其中，所述外加固层为脱细胞脱抗原的巩膜片，所述水凝胶内层贴附于外加固层上，由携载巩膜细胞外基质凝胶的生物相容性材料交联制备，具备多孔结构。该双层后巩膜加固生物材料具有一定机械性能和粘附性，水凝胶内层仿照巩膜细胞外基质，紧贴巩膜表面呈现出适应细胞三维生长的多孔结构，可以促进细胞迁移增殖和促进血管生成，促进巩膜重塑。

人工心脏及其制备方法、人工心脏装置及控制方法

Resumen de: CN121401590A

本发明属于医疗器械技术领域，具体涉及一种人工心脏及其制备方法、人工心脏装置及控制方法。其中，所述人工心脏的心肌包括若干六边形腔室组成蜂巢结构的环形阵列。本发明提供的人工心脏，具有的仿生蜂巢结构，各六边形腔室可以通入不同体积的气体，从而实现不同形状心脏房室形状模拟。

System for producing three-dimensional medical images using a calibration slate

Resumen de: US12536703B1

A system produces three-dimensional medical images that are calibrated using a calibration slate. A subject is photographed with a calibration slate shown in the image. The slate includes printed colors that can be compared against standard colors associated with the slate to color calibrate the image. Two-dimensional images of the subject may be used to construct a three-dimensional image that shows wounds or other skin conditions that are color calibrated.

一种肱骨近端骨折修复体的制备方法及其修复体

Resumen de: CN121401019A

本发明涉及医疗器械技术领域，且公开了一种肱骨近端骨折修复体的制备方法，包括以下步骤：获取患者肱骨近端CT影像数据，通过医学影像处理软件构建三维数字化骨骼模型；基于所述三维数字化骨骼模型，采用参数化设计算法确定修复体的个性化适配参数，所述个性化适配参数包括解剖角度参数、髓腔曲率参数和尺寸规格参数；根据所述个性化适配参数，通过计算机辅助设计软件生成模块化修复体的数字化模型，所述数字化模型包含通过拼接结构连接的第一承载部件和第二承载部件，以及设置于两部件之间的调节连接部件。本发明的目的是能够实现个性化精准适配、具备术中调节能力、并融合先进制造与生物活性技术。

一种TC4钛合金骨科假体构件、股骨柄及其热处理方法

Resumen de: CN121407005A

本发明涉及骨科植入假体技术领域，具体公开了一种TC4钛合金骨科假体构件、股骨柄及其热处理方法。其中，该热处理方法包括：S101，采用点曝光式激光3D打印工艺制造TC4钛合金骨科假体构件，得到第一构件；S102，将第一构件放置于真空热处理炉进行去应力退火，得到第二构件；S103，采用热等静压方式对第二构件进行热处理，然后冷却，得到α/α’+β相双态组织的第三构件；S104，采用高温固溶方式分解残余亚稳态相α’相，且固溶后利用水淬进行快速冷却抑制α’相重新生成，形成细晶网篮状α+β相组织的第四构件；S105，采用时效工艺，消除水淬快速冷却过程形成的残余应力，得到第五构件。

一种基于SLM成形与组织调控的抗菌钛合金植入物制备方法

Resumen de: CN121402647A

本发明公开了一种基于SLM成形与组织调控的抗菌钛合金植入物制备方法，将Ti‑6Al‑4V预制合金粉末和纯Cu粉末按预定比例均匀混合，获得Ti‑6Al‑4V‑Cu混合粉末；采用选择性激光熔化（SLM）工艺，在惰性气氛保护下将所述混合粉末逐层熔化沉积，得到近净成形的Ti‑6Al‑4V‑Cu合金构件；对所述合金构件进行热处理，调控为含α+α″非均质双相组织的Ti‑6Al‑4V‑Cu合金。无需复杂的预合金化制粉工序，减少了Ti‑6Al‑4V‑5Cu合金专用预制粉的制备步骤，降低了工艺难度与生产成本。通过SLM工艺采用铺粉方式进行打印，可实现复杂结构的一次成形，制品尺寸精准、形状不受限制，材料利用率高，非均质α+α″双相的结合使合金在保持高抗拉强度的同时显著降低整体弹性模量，实现高抗拉强度与低模量的协同优化。

基于4D打印的智能颈托、工作方法及制备方法

Resumen de: CN121401029A

本申请适用于医疗康复器械技术领域，提供了基于4D打印的智能颈托、工作方法及制备方法。该智能颈托包括颈托主体、可充气构件、充气源、运动传感器和控制器。颈托主体的至少一部分包含形状自适应4D打印材料，可在预设刺激下改变形状以贴合用户轮廓。控制器获取并分析运动传感器监测的运动数据，当识别到危险运动条件时，控制充气源为可充气构件充气以限制颈部运动，危险解除后则控制其放气。本申请还公开了该颈托的工作方法和制备方法。本申请的智能颈托能够兼顾个性化舒适贴合与实时主动防护，解决了现有技术中颈托舒适性差且仅能被动防护的问题，显著提升了佩戴安全性与舒适性。

一种增材制造的空心股骨髁假体及其制作方法

Resumen de: CN121370444A

本发明涉及一种增材制造的空心股骨髁假体及其制作方法，属于人工膝关节假体技术领域。本发明的空心股骨髁假体包括股骨髁本体、堵销及可选的多孔结构。股骨髁本体设有连通的空腔，空腔可配置加强筋以增强刚性。假体内型面（如前髁面、远端截骨面等）用于与股骨远端截骨面匹配定位，外型面（如外侧髁、内侧髁）与胫骨垫和髌骨形成关节面。非骨水泥型假体设有多孔结构，其厚度为0.6‑2mm，用于骨长入生物固定；骨水泥型假体设有骨水泥凹槽用于术中固定。假体关节面采用高抛光氧化锆涂层（粗糙度低于Ra0.05），有效降低磨损。假体采用钛合金或钴铬钼合金通过激光增材制造一体成型，确保精度和强度，提升制造效率。

一种防数据造假的实验动物体征信息采集装置及方法

Resumen de: CN121384121A

本发明提供了一种防数据造假的实验动物体征信息采集装置，包括信息采集模块、实验目标放置模块以及信息处理模块；所述信息采集模块包括图像采集部以及旋转部；所述旋转部带动所述图像采集部以实验目标为中心转动，实现360°采集实验目标的图像数据；所述实验目标放置模块包括托盘和压力传感器；所述压力传感器用于对实验目标进行称重；所述信息处理模块收集图像采集部以及压力传感器的信息，并反馈通过信息处理模块的显示屏显示出来。应用本技术方案可实现实验动物各种体征信息的同时采集。

3D打印透明牙托表面后处理方法

Resumen de: CN121375114A

本发明涉及牙托打印技术领域，具体涉及3D打印透明牙托表面后处理方法，包括以下步骤：步骤一、使用树脂清洗剂对牙托打印件进行清洗；步骤二、对清洗后的牙托打印件进行打磨处理，以去除牙托打印件表面的缺陷结构；步骤三、采用树脂在牙托打印件表面形成厚度在8‑15μm的流体树脂层；步骤四、对流体树脂层做固化处理，得到成品牙托。本申请能够制作透明度较高的牙托。本申请在牙托打印件表面形成厚度在8‑15μm的流体树脂层，并固化流体树脂层，此时，成品牙托的外表面为流体树脂层的外表面，流体树脂层可以通过填充方式使得牙托打印件表面平整，例如，流体树脂层可以填充打磨过程带来的划痕，避免这些表面缺陷影响到成品牙托的透明度。

基于3D打印的可吸收冠脉支架及其制备方法

Resumen de: CN121370458A

本发明公开了一种基于3D打印的可吸收冠脉支架及其制备方法，其包括沿轴向依次排列的若干环形单元以及连接相邻环形单元的连接单元；所述环形单元为闭环的环形基体，所述环形单元沿轴向进行功能分区，具体包括：用于提供径向支撑力的第一单元，布置于钙化区；用于实现药物释放功能的第二单元，布置于长病变区；用于提供刚柔过渡以及应力缓冲的第三单元，布置于大弯曲区。本发明通过结构、材料和功能的协同分区，解决了传统支架径向支撑力与柔顺性的对立矛盾，有效降低了支架植入后的局部应力集中，提高了支架对血管的长期兼容性，并实现了药物的精准时序释放。

一种基于胶原纤维-羟基磷灰石合成的复合弹性支架及其制备方法、应用

Nº publicación: CN121371309A 23/01/2026

Solicitante:

华东理工大学

Resumen de: CN121371309A

本发明涉及生物医用材料与再生医学技术领域，尤其是一种基于胶原纤维‑羟基磷灰石合成的复合弹性支架及其制备方法、应用。所述的复合弹性支架由胶原蛋白与羟基磷灰石复合形成，胶原蛋白自组装形成胶原纤维网络，羟基磷灰石在胶原纤维网络中均匀分散；其制备方法如下：将酸性胶原溶液和羟基磷灰石悬浮液混合形成打印墨水，经超声与低速离心除泡后在卡波普支撑浴中进行三维打印→温控孵育形成胶原纤维网络结构→含盐缓冲液洗除支撑浴→交联处理→冷冻干燥得到多孔弹性支架。本发明表现出弹性结构特征、可观察的血液吸收及因子凝集行为，并在动物骨‑软骨缺损模型中显示出良好的修复能力及生物相容性，用于骨软骨损伤修复等组织工程领域。