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178
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06/07/2025 [07:18:00]
Resultados 25 a 50 de 178
Resumen de: US2025213355A1
Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.
Resumen de: US2025213327A1
A process for manufacturing a retainer, said process comprising the following steps: a) at an update time, after the end of an orthodontic treatment, acquiring at least one two-dimensional image of at least one portion of a dental arch of a user, called the “updated image”, by means of an image-acquiring apparatus; b) generating a digital three-dimensional model representing the dental arch of the user, called the “updated model”, based on the updated image; c) designing, based on the updated model and preferably by computer, a retainer suitable for keeping teeth in their configuration at the update time; d) manufacturing the retainer.
Resumen de: US2025213352A1
Methods for producing a custom-made stapes prosthesis for a patient and stapes prostheses so produced. The methods may include obtaining a three-dimensional image of a natural stapes bone of the patient; and forming a stapes prosthesis that closely approximates a three-dimensional shape of the natural stapes bone via an additive manufacturing technique based on the three-dimensional image. The stapes prosthesis comprises a suitable material that is not osteogenic and is not cytotoxic. The stapes prosthesis may include a plurality of pores having an average size of from about 5 to about 100 micrometers and may exhibit a frequency of sound transmission in a range of from about 2 to about 30 kilohertz.
Resumen de: US2025212852A1
An artificial structure for promoting microalgae growth includes a 3D-printed structure formed by positioning a printing surface on a movable stage of a 3D bioprinter in contact with a bio-ink that includes a mixture of a pre-polymer material with one or more of cellulose-derived nanocrystals (CNC), and microalgae cells. By projecting modulated light onto the printing surface while moving the stage, the bio-ink is progressively polymerized to define layers of an artificial coral structure with microalgae cells disposed thereon, where the artificial coral structure is configured to scatter light within the structure.
Resumen de: US2025215166A1
This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.
Resumen de: TW202416928A
A drug delivery system includes a container comprising a luer compartment and a fluid compartment, a luer fitting arranged within the luer compartment and in fluidic communication with the fluid compartment, and a dispenser in fluidic communication with the fluid compartment. A method of aseptically transferring a drug to such a drug delivery system may include providing a vial comprising the drug to be transferred, withdrawing a volume of the drug from the vial with a syringe, coupling the syringe to a drug delivery system via the luer fitting, transferring the drug from the syringe to the drug delivery system, and decoupling the syringe from the drug delivery system.
Resumen de: WO2024044071A1
Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.
Resumen de: TW202416928A
A drug delivery system includes a container comprising a luer compartment and a fluid compartment, a luer fitting arranged within the luer compartment and in fluidic communication with the fluid compartment, and a dispenser in fluidic communication with the fluid compartment. A method of aseptically transferring a drug to such a drug delivery system may include providing a vial comprising the drug to be transferred, withdrawing a volume of the drug from the vial with a syringe, coupling the syringe to a drug delivery system via the luer fitting, transferring the drug from the syringe to the drug delivery system, and decoupling the syringe from the drug delivery system.
Resumen de: EP4578633A2
The invention relates to a method for partial curing of an initial photoreactive material for 3D printing, comprising the steps of:a) providing an item (1) comprising the initial photoreactive material for 3D printing,b) a partial irradiation step comprising irradiating at least one curing section (20) of the initial photoreactive material for 3D printing of the item with a curing irradiation, yielding at least one cured section (120) of a partially-cured item (10), and at least one semi-curing section (40) of the initial photoreactive material of the item is irradiated with a semi-curing irradiation, yielding at least one semi-cured section (140) of the partially-cured item.
Resumen de: AU2023330160A1
The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof,
Resumen de: AU2023327795A1
A teat product having a base portion and a nipple portion extending from the base portion, the teat product having a pliable region, wherein said pliable region of the teat product is configured to be deformable in shape in response to force applied by a mouth of a feeding infant.
Resumen de: WO2023231904A1
A dental instrument and orthodontic system, comprising: a first shell-shaped body (10) for accommodating maxillary teeth and a second shell-shaped body (20) for accommodating mandibular teeth. The buccal or lingual side of the posterior tooth area of the first shell-shaped body (10) is provided with a first type of protrusion (11), and the buccal or lingual side of the posterior tooth area of the second shell-shaped body (20) is provided with a limiting part (21) that cooperates with the first type of protrusion (11). The first type of protrusion (11) and the limiting part (21) interact with each other to adjust the relative positional relationship between the upper and lower jaws. The occlusal surface of the posterior tooth area of the first shell-shaped body (10) or the second shell-shaped body (20) is provided with a second type of protrusion (12) that protrudes toward the opposite jaw. The height of the second type of protrusion (12) compensates for the jaw opening space formed in the posterior tooth area after the interaction between the first type of protrusion (11) and the limiting part (21) to stabilize the occlusion state.
Resumen de: CN120227186A
本发明涉及曲面仿生结构制造技术领域，尤其涉及一种具有微纳结构调控的仿生支架制备方法；包括以下步骤：S1、制备仿生支架所对应的芯体外层；具体包括：S101、获取待替代曲面结构的影像文件数据；S102、对S101步骤获取的影像文件进行模型重建，获取待替代曲面结构真实曲面曲率的三维模型信息；S103、对三维模型信息进行去除噪音、法相修复、封装操作，获取结构模型；S104、将结构模型导入逆向重建软件中，进行芯体外层的结构设计；S105、制造出设计后的芯体外层；S2、将S1制备的芯体外层放置在旋转轴平台上，完成仿生支架的制备；有助于调控所制备仿生支架的力学性能，保证复杂仿生支架的构建。
Resumen de: CN120228896A
一种具有倒钩结构的微针电极阵列的制备方法，包括：采用三维打印技术，在承载胶带上形成微针前驱体的阵列和连接微针前驱体的连接线，微针前驱体包括针体和连接针体的至少一连接部，针体沿轴向延伸呈针状，且沿轴向具有相对的底端和针尖端，连接部位于底端和针尖端之间且垂直所述轴向；提供模具，通过模具挤压微针前驱体，使连接部朝针体的底端弯曲变形形成倒钩，并固化微针前驱体形成为微针本体；对微针本体和连接线的表面进行金属化，以使微针本体形成微针电极且连接线形成为导线。本申请的制备方法，可以方便快捷地制备出具有弯曲的倒钩结构的微针电极。
Resumen de: CN120227504A
本发明提供了提供一种墨水组合物，所述墨水组合物包括载药微球、羟基磷灰石、海藻酸钠、卡拉胶。本发明的墨水材料具有良好的剪切稀变性能，流变性能，稳定性和自愈能力。本发明的支架具有良好的力学强度，亲水性能。本发明的支架安全，没有细胞毒性。并通过将NGF融合入骨支架中，可以实现局部持续释放，确保对修复部位的作用持久有效。
Resumen de: US12343268B1
A sleeve generally shaped as a limb and an overlapping area of curvature formed in the sleeve extending a length of the sleeve. A clasp is formed from slicing the overlapping area of curvature the length of the sleeve along a line substantially perpendicular to a transverse plane to create a first end and a second end. The sleeve is openable to separate the first end and the second end of the clasp for fitting the sleeve around the prosthesis and latchable by fitting the first end of the clasp over the second end of the clasp.
Resumen de: CN120227493A
本发明提供一种3D打印的组织粘合贴片及其制备方法和用途。3D打印的组织粘合贴片包括：相接触的支撑层和粘合剂层；其中，所述支撑层源自于成膜组合物，所述成膜组合物包括聚酯化合物，所述支撑层和所述粘合剂层采用3D打印技术制备得到；并且，所述组织粘合贴片的厚度H1为8μm～30μm，所述组织粘合贴片具有不低于28kPa的破裂强度。本发明的3D打印的组织粘合贴片，在具有较薄厚度的情况下，能够同时具有优异的粘合性和组织顺应性，且破裂强度不低于28kPa，能够在压力条件下更好的顺应组织运动，并在组织表面保持紧密的、持久的粘附，有效的抑制伤口附近组织的拉伸变形造成的伤口撕裂。
Resumen de: WO2024076590A2
Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.
Resumen de: KR20250097374A
본 발명은 마그네슘 기반 합금을 이용한 생체분해성 임플란트 제조방법에 관한 것으로, 인체 임플란트를 3차원 모델로 구성하는 단계, 상기 3차원 모델 구성단계 이후 3차원 모델에 중공격자를 디자인하는 단계, 중공격자를 갖는 3차원 모형에 소정의 마그네슘 분말을 도포 블레이드를 통해 10~60㎛ 적층간격으로 도포하는 단계, 상기 3차원 모형에 마그네슘 분말을 도포후 소결챔버에서 1064~1070㎛ 파장의 레이저로 소결하는 단계를 포함하고, 상기 소결 단계에서 상기 레이저의 스캔경로를 다르게 적용하여 3차원 모형의 표면에 적어도 1개층 이상의 세포재생촉진층을 형성한다.
Resumen de: WO2024086372A1
A system and method of adjusting a dental appliance by modifying a corresponding digital dental appliance model. The system includes an additive manufacturing system (e.g., a 3D printer system) and a controller running software. The system is designed to (i) 3D print a dental appliance using an initial digital dental appliance model, (ii) determine any portions of the printed dental appliance that may require modification, (iii) automatically adjust the appliance's digital model by performing pixel offsetting to implement a modification, and (iv) reprint the appliance using the modified digital model.
Resumen de: CN120203825A
本发明公开了一种基于弹性模量适配的新型仿生正畸种植钉结构，涉及正畸种植钉技术领域，包括种植钉本体，所述种植钉本体的内部设有孔隙结构，或者所述种植钉本体的内部以及表面均设有孔隙结构。本发明提供了一种具有多孔结构的种植钉本体，通过不同孔隙率调控种植钉本体的弹性模量，可以制备出不同弹性模量的仿松质骨结构的种植钉本体，以适应临床上不同骨密度的正畸患者的牙槽骨条件，提高种植钉本体植入后的成功率及正畸效果。
Resumen de: KR20250096319A
3차원 유동 장애물을 갖는 테슬라 구조가 도입된 미세유체 혼합장치가 개시된다. 본 발명의 미세유체 혼합장치는, 투입된 복수의 유체에 대한 혼합을 가능하게 하는 미세 유체 믹서; 상기 미세 유체 믹서의 상부 일측에 배치되어, 혼합 예정인 물질들을 주입하는 적어도 하나 이상의 유입구; 및 상기 미세 유체 믹서의 상부 타측에 배치되어 혼합된 물질을 방출하는 유출구;를 포함하고, 상기 미세 유체 믹서는, 믹서 하우징; 상기 믹서 하우징 내에 길이 방향을 따라 형성된 메인 혼합 유로; 상기 메인 혼합 유로를 따라 형성되는 복수의 테슬라 믹서 유닛; 및 상기 메인 혼합 유로에 형성되는 유동 장애물; 을 포함하여, 투입된 유체의 혼합을 원활하게 할 수 있다.
Resumen de: CN120204460A
本发明提供了一种以钛合金为骨架增强相的铝基仿生复合材料及其制备方法，属于金属基复合材料领域。本发明提供的以钛合金为骨架增强相的铝基仿生复合材料，包括铝基体和钛合金骨架增强相；所述钛合金骨架增强相具有仿生牙釉质柱状微观结构特征的多孔结构，所述多孔结构为密排分布的圆柱状贯穿孔；所述铝基体填充于所述圆柱状贯穿孔中；所述以钛合金为骨架增强相的铝基仿生复合材料中钛合金骨架增强相的体积百分比为30～80％。本发明提供的铝基仿生复合材料的拉伸强度可达到811MPa，断后延伸率可达到10.3％，弯曲强度可达到1491MPa，断裂韧性可达到47MPa·m1/2，展现出优异的强韧协同效应。
Resumen de: CN120203810A
本发明公开了一种贴合患者颅骨的骨膜牵张装置，包括牵张板，牵张板的端部设置为弧形尖端，牵张板的表面为弧面，且能够与弧形尖端顺滑过渡；牵张板由液压机以及与患者颅骨数据相匹配的模具冲压成型；牵张板上开设有螺纹孔和多个固定孔；还包括牵张螺钉、螺纹针、转接头和钻头；其中，牵张螺钉上设有两端贯穿的内孔，螺纹针的一端以及钻头的一端均能够穿过内孔；螺纹针上固定连接有限位块a，钻头上固定连接有限位块b。本发明骨膜牵张装置中的牵张板，通过与患者颅骨数据相匹配的模具（凸模和凹模的组合）冲压成型，成型后的牵张板表面与颅骨表面的形状一致，能够非常良好的贴合颅骨与骨膜，利于骨膜牵张和恢复。
Nº publicación: CN120203902A 27/06/2025
Solicitante:
北京中医药大学第三附属医院
Resumen de: CN120203902A
本发明提供一种骨折固定装置控制方法，属于医疗器械技术领域，当骨折固定装置的夹持力不再适用于患者时，需要对第一压板和第二压板之间的压力值进行调整。首先通过压力传感器获取实时压力值，然后根据预设公式，结合预设的参数对驱动器的活动量进行调整，并在调整的过程中不断对压力值进行动态调整，直到实际压力值与预设压力值之间的差值小于设定阈值，通过动态迭代，将第一压板和第二压板之间给与患者的压力调整至最优值。无需患者进行手动调整，通过控制器中程序即可对骨折固定装置的加持力以及骨折固定装置的形状进行微调，在确保调整精度的同时，可以有效地确保对患者的治疗精确性。
BOPI
Sede Electrónica
