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应用于3D打印的铌铜合金粉末、其制备方法及应用

Resumen de: CN120243953A

本发明公开了应用于3D打印的铌铜合金粉末、其制备方法及应用，3D打印技术领域。本发明采用喷雾造粒和等离子体球化工艺相结合的方法制备Nb‑Cu合金粉末，制备得到的铌合金粉末致密且为球形，具有极佳的流动性与堆积密度，匹配合适的3D打印工艺参数，使得样品成型后的致密度高达99.5％，远高于其他传统粉末冶金烧结法制备的样品致密度。同时，铌合金粉末中Cu已经均匀分散，而且氧含量低，使得金属制品的组成非常均匀，加之激光选区熔融成型工艺具有极高的冷却速率，使得金属制品的晶粒较小，因此本方法制备的3D打印铌铜合金制品具有较好的机械性能，可制备形状更为复杂的骨科医疗零件。

负压产生装置及应用

Resumen de: CN120242203A

本发明公开了负压产生装置及应用，该装置包括本体和连接于本体的握持部，本体顶端设有开口，本体底端设有多个通孔，开口和通孔之间连接壁面，使壁面内由开口至通孔形成腔体；本体还设有：控制模块，控制模块设于壁面外；料仓，料仓为无顶盖的筒状结构；筒底部设有若干小孔；料仓上设有升降模块，所述升降模块连接驱动机构以使料仓在腔体内进行上升或下降；驱动机构连接控制模块；握持部两端开口，一端连通于本体的底端，另一端为负压作用口。本发明的负压产生装置结构简单，使用方便，该装置底部的负压作用口可精准适配身体各个部位，用于在身体部位产生负压。通过控制模块对升降模块的位移，使料仓靠近或远离负压作用口，实现负压作用口附近的自动控温。

一种医用镁合金锚钉及其制备方法

Resumen de: CN120242145A

本发明涉及医疗器械技术领域，尤其涉及一种医用镁合金锚钉及其制备方法，其技术方案包括锚钉材料，所述锚钉材料是由3D打印制备的二氧化锆、聚己内酯、PLGA中的至少一种构成了镁合金锚钉的外结构支架；另外三种镁、锌、钙合金粉末制备得到的复合非晶合金填充在支架的孔隙当中，最后在锚钉表面进行表面处理。本发明相比于传统的镁合金锚钉，本发明利用3D打印的外结构支架以及内部高强度的非晶复合镁合金，为锚钉提供了稳定的支撑结构，这种结构设计能够有效维持植入后结构稳定性，在腐蚀后开始后也不会出现因为点蚀导致的力学性能瞬间丧失，克服了传统锚钉在骨内可能出现的由于早期腐蚀导致的结构完整性破坏、变形、移位等问题。

一种3D打印模型

Resumen de: CN120241299A

本发明公开了牙种植体技术领域的一种3D打印模型，包括模型本体和模型基台，所述模型本体的上端固定开设有安装孔，所述安装孔的内部设有螺纹，所述模型本体的下端固定连接有连接轴杆，所述连接轴杆的表面固定设置有固定螺纹圈，所述模型基台的表面固定开设有安装槽口，所述安装槽口的底部固定开设有固定孔，所述固定孔的内部设置有固定螺纹。此设置使得种植体固定效果更好，不会产生轻微转动，同时整个工艺因不需要使用替代体的缘故，对工艺进行了良好的简化，减轻了产品的生产力压力。

用于生产三维微孔细丝构建体的方法

Resumen de: WO2024133278A1

A method for producing a three-dimensional macro-porous filament construct having interconnected microporous filaments comprises: a) preparing a mixture comprising particles of one or more metals, one or more metal alloys or a combination thereof, one or more binders, a first liquid solvent for the one or more binders, and optionally one or more dispersants; b) dispersing particles containing at least one removable additive in said mixture; c) depositing said mixture in the form of filaments in a predetermined three-dimensional pattern of interconnected filaments, thereby creating a three-dimensional filament-based porous green structure; d) contacting the three-dimensional filament-based porous green structure formed in step c) with a second solvent which is a non-solvent for the one or more binders to induce phase inversion thereby creating a filament-based phase inverted porous structure having a filament micro-porosity, whereby at least part of said filaments are transformed to a solid state; e) removing the at least one removable additive by dissolving in a removal agent to create additional micro-porosity in the phase inverted porous structure; f) subjecting the thus obtained structure to a thermal treatment. The removal agent comprises or consists of the second liquid solvent, or the removal agent is a third liquid solvent distinct from the second liquid solvent.

一种高通量多材料3D打印机

Resumen de: CN120245413A

一种高通量多材料3D打印机，属于打印机设备技术领域，包括打印机本体，还具有控制系统、打印系统和环境系统；控制系统包括3D打印机的控制主板、操作屏幕、电脑主机；打印系统包括多套龙门架构、传送带打印平台、阵列打印喷嘴机构、生物墨水池、蠕动泵、控温模组、光照模组、零件盘，环境系统包括洁净模块、灭菌模块、温度及湿度控制模块，控制系统、打印系统和环境系统和打印机本体安装在一起。本发明实现了同时打印多个模型的能力，大幅提高了打印效率；打印过程形成流水线模式，进一步提高了生产效率；能根据不同打印需求更换不同类型的打印喷嘴、使用更加便利；为生物材料打印提供了理想的环境条件；能确保打印过程的精准和稳定。

一种基于3D打印的可矿化引导骨再生膜及其制备方法和应用

Resumen de: CN120242154A

本发明提供了一种基于3D打印的可矿化引导骨再生膜及其制备方法和应用，涉及骨组织再生技术领域。本发明中所述可矿化引导骨再生膜的制备方法包括前驱液制备、DLP 3D打印、表面矿化等步骤。本发明通过数字光处理3D打印技术保障膜的结构适配性，通过ZIF‑8矿化层激活成骨细胞生物活性，通过智能降解体系维持膜的力学支撑与骨再生动态平衡，最终实现“结构‑功能‑代谢”三位一体的骨修复调控，具有优异的临床转化潜力。

一种负泊松比的光致动器

Resumen de: CN120242306A

本发明属于医疗器械技术领域，涉及一种负泊松比的光致动器，包括负泊松比框架、液晶弹性体套管和光纤。负泊松比框架的结构单元为双箭头形，双箭头形由高V形和低V形组成，高V形的两边等长，低V形的两边等长，低V形位于高V形内，低V形的两端分别与高V形的两端连接；液晶弹性体套管的中心轴平行于负泊松比框架的纵向，与负泊松比框架固定连接，位于负泊松比框架的内部正中间；液晶弹性体套管的中心轴与光纤的出射光轴共线，液晶弹性体套管的后端套在光纤的前端上；液晶弹性体套管受到从光纤出射的红外激光照射时收缩，去除所述红外激光照射后回弹。本发明采用负泊松比结构与光致动方式，使器件力学性能与心脏收缩特性匹配。

一种用于低特征表面的磁锁定3D打印弹性导板及其制作方法

Resumen de: CN120241176A

本发明关于一种用于低特征表面的磁锁定3D打印弹性导板及其制作方法，涉及手术导板技术领域。包括导向通道、刚性连接段、磁吸座和弹性连接轴；导向通道贯穿设置在弹性连接轴顶部的中间位置，弹性连接轴的两端均连接有刚性连接段，刚性连接段的两端均连接有磁吸座，磁吸座底端设置有凹槽，凹槽内嵌设有磁体。本发明针对人体低特征表面，以及具有一定活动度的部位，能够实施手术精准定位，彻底解决了人体低特征区域定位问题。

一种可溶性微针及其制备方法

Resumen de: CN120242289A

本发明公开了一种可溶性微针及其制备方法，可溶性微针包括针尖和基底，所述基底包括上表层、中空层和下表层；所述针尖由上针和下针组成；基底的上表层和下表层均为非离子型高分子化合物；针尖的上针为疏水类的有机硅物料，下针为带电荷的高分子材料；其中上针为中空圆柱体，下针呈菱形，上针与下针承插连接，药物设置在中空层和下针；本发明提供一种可溶性微针，利用该微针可根据用药计量的要求，调整微针载药量，适用性强。

一种智能可控超变形鼻假体

Resumen de: CN120241325A

一种智能可控超变形鼻假体，属于整形外科医疗器械领域，将内凹型空心Ω形结构框架主体壳层、Janus界面外覆涂层与智能响应材料结合，构造“解剖‑结构‑功能”一体化鼻假体，在鼻假体腹侧进行微孔设计和羟基磷灰石涂层，形成高贴合性、高稳定性的鼻假体结构，在鼻假体背侧进行光滑设计和亚精胺涂层，从而抑制包膜形成，避免包膜约束，结合内凹型空心Ω形结构设计，实现超定向变形性能，智能响应材料的应用可在术中或术后通过温度信号进行非侵入式变形调整，满足术中与术后微调的临床需求。鼻假体可应用于整形、术后修改、修复重建等场景中，满足更高层次的医疗与美学需求。

颅骨缺损修复材料及其3D打印制备方法

Resumen de: CN120242142A

本发明公开了一种颅骨缺损修复材料及其3D打印制备方法。颅骨缺损修复材料的3D打印制备方法包括利用由聚己内酯和含镁磷酸三钙粉体得到的丝材，通过3D打印获得具有预定形状和尺寸的颅骨缺损修复材料；所述3D打印制备方法还包括热压退火步骤：将制备的颅骨缺损修复材料置于40‑75℃的环境下，同时向所述颅骨缺损修复材料施加压力，以进行热压退火，获得成品材料。该颅骨缺损修复材料具有降解周期长、生物活性优和力学强度高的优点。

A MAGNETIC SUBSTRATE BASED TISSUE SCAFFOLD AND A METHOD FOR THE PRODUCTION OF THIS TISSUE SCAFFOLD WITH THE SUPPORT OF A 3D PRINTER

Resumen de: WO2025144252A1

The invention relates to a magnetic substrate based tissue scaffold suitable for use in the growth, proliferation, and organization of cells in the technical field of tissue engineering, provided with intelligent behavior characteristics and thus dynamic structure, and a method for the production of this tissue scaffold with the support of a 3D printer.

APPARATUS AND METHOD

Resumen de: US2025214302A1

We describe an apparatus for producing a three-dimensional workpiece, the apparatus comprising: a process chamber for receiving a material from which the three-dimensional workpiece is producible using an additive layer manufacturing technique, wherein the process chamber comprises a translucent window; an irradiation device for irradiating, through the translucent window, the material for producing the three-dimensional workpiece; and an enclosure arranged between the translucent window of the process chamber and the irradiation device, wherein at least a part of the enclosure is translucent for an irradiation beam stemming from the irradiation device to travel from the irradiation device through the enclosure to the material for producing the three-dimensional workpiece, wherein the enclosure comprises an inlet and an outlet, and wherein the apparatus is configured to control a flow of a fluid through the enclosure via the inlet and the outlet.

A BIOPRINTED LIVER MODEL, A METHOD FOR MANUFACTURING THE LIVER MODEL AND THE USE THEREOF IN CYTOTOXICITY EVALUATION

Resumen de: WO2025141425A1

A bioprinted liver model with a vascular system consisting of layers and comprising at least one flow channel in which: the first two layers forming the base of the model are 100% filled with bioink, and wherein layer 1 is positioned at an angle of 0° to the flow channel and layer 2 is positioned at an angle of 90° to the flow channel, the inner layers of the model are filled from 20% to 100% with bioink, wherein the inner layers comprise a centrally located at least one flow channel, the perimeter of which is printed with 100% filling and in which every inner layer is arranged at an angle of 60° with respect to the previous layer, the last two layers enclosing the model: the penultimate and the last layer are 100% filled with bioink and wherein the penultimate layer is arranged at an angle of 0° with respect to the flow channel and the last layer is arranged at an angle of 90° with respect to the flow channel, wherein the bioink used is based on natural polymers, synthetic polymers, methacrylated derivatives of natural polymers or mixtures thereof. A method for manufacturing the liver model and the use thereof.

ELECTRODE MODULE, HEARING ASSISTANCE DEVICE INCLUDING SAME, AND MANUFACTURING METHOD THEREOF

Resumen de: WO2025143324A1

A hearing assistance device and a manufacturing method thereof are provided. The hearing assistance device according to an aspect of the present invention is a hearing assistance device for assisting hearing, and the hearing assistance device may comprise: a sound processor for converting sound into a predetermined signal; a transmitter provided outside the body to transmit the signal to the outside; a receiver provided inside the body to receive the signal transmitted by the transmitter; and an electrode array including a plurality of electrode modules connected to each other in a ball-joint manner and inserted into the cochlea, and emitting a current corresponding to the signal received by the receiver.

3D BIO-PRINTING INTEGRATED CLEAN SYSTEM

Resumen de: WO2025143427A1

The present invention relates to a 3D printing integrated clean system that can maintain the cleanliness, temperature, and humidity of a 3D printer device, and at the same time, maintain the cleanliness, temperature, and humidity of pre-printing and post-printing zones or devices. The 3D printing integrated clean system comprises: a housing in which are defined a printer zone having a 3D printer or a 3D bio-printer installed therein and at least one operation zone, positioned on at least one side of the printer zone, for performing operations other than printing; a base movement stage which is installed in the housing and can move between the 3D printer zone and the at least one operation zone; an air supply unit which is installed at an upper end portion of the housing, and which provides clean air to the 3D printer zone and the at least one operation zone and controls the flow of the air; and a temperature and humidity control device, which is installed in a zone other than the lower surface of the housing, for controlling the temperature and humidity of the 3D printer zone and the at least one operation zone.

PHOTOCURABLE SHAPE-MEMORY POLYMER COMPOSITION FOR DIRECT 3D PRINTING, AND ORTHODONTIC DEVICE MANUFACTURED USING SAME

Resumen de: WO2025143784A1

The present disclosure relates to a photocurable shape-memory polymer composition for direct 3D printing, and an orthodontic device manufactured using same, and, more specifically, to a photocurable shape-memory polymer composition for direct 3D printing, and an orthodontic device manufactured using same, the composition exhibiting rigidity, stiffness and elasticity that are suitable for orthodontics in a first temperature range and exhibiting original shape restoration characteristics in a second temperature range that differs from the first temperature range.

BIOINK AND METHOD FOR PRODUCING STRUCTURE

Resumen de: US2025215390A1

The present invention relates to a bioink containing a fragmented extracellular matrix component.

OSSICULAR PROSTHESES AND METHODS FOR MIDDLE EAR RECONSTRUCTION

Resumen de: US2025213353A1

Ossicular prostheses, and methods for producing such, are disclosed for treatment of middle ear damage caused by a malady of the middle ear such as cholesteatoma. The ossicular prostheses comprises a strut component attached to a disc via a rigid or flexible connecting joint. The strut is attachable to a head or footplate of a subject's stapes. The disc is attachable to the subject's existing tympanic membrane, or, alternatively, to an artificial tympanic membrane graft. In some embodiments, a scaffold is used to support the ossicular prosthesis and the tympanic membrane graft.

A 4D-PRINTED HUMIDITY AND MAGNETIC DUAL RESPONSIVE ACTUATOR

Resumen de: US2025213312A1

The present invention provides a 4D-printed humidity and magnetic dual responsive actuator with a bilayer structure, including a hydrogel film and a numerous of magnetic elastomer filaments, the numerous of magnetic elastomer filaments are printed on the hydrogel film to formed the bilayer structure, wherein the magnetic elastomer filaments are elastomer filaments embedded with magnetic particles, and the dual responsive actuator capable of responding to both humidity and magnetic fields, resulting in a reversible deformation that transforms into helix structures. The printed actuators can initially deform into helix structures in response to humidity stimuli and rapidly contract to a smaller size with the activation of a magnetic field. The shape deformation of this dual-responsive actuator is programmable and reversible, with stable and excellent repeatability.

Ventilation System

Resumen de: US2025213809A1

A system includes a container configured to contain a liquid. The system also includes a tubing apparatus having a first port configured for connection to a gas source, a second port configured for connection to a patient interface, and a third port configured for submersion within the liquid. The system also includes an actuator configured to move the third port vertically within the container. A method includes flowing gas into the first port of the tubing apparatus to the patient interface via the second port of the tubing apparatus. The method also includes moving the third port of the tubing apparatus vertically within the container such that an amount of the liquid in the container that is above the third port changes, thereby changing a pressure at the patient interface.

A TECHNOLOGY FOR COMBINATORIAL LIQUID HANDLING

Resumen de: US2025214047A1

Various devices and methods covering a technology for combinatorial liquid handling. At least some example embodiments of the devices may include a plurality of liquid dispensers configured to dispense drops, wherein at least a carrier drop is dispensed and sequentially collides and merges with drops dispensed from a sub-plurality of liquid dispensers, so that liquids from the sub-plurality of liquid dispensers are located in the carrier drop during flight, and a support surface being positioned so that the carrier drop lands on the support surface.

METHOD OF ANIMAL-DERIVED TISSUE DECELLULARIZATION AND BIOINK COMPRISING ANIMAL-DERIVED DECELLULARIZED TISSUE

Resumen de: WO2025141426A1

A method of decellularization of animal tissue, comprising the steps of: mechanical homogenization of animal-derived tissue, incubation of the homogenized tissue from step a) in a solution of trypsin and EDTA, subjecting the filtered tissue to incubation in a PBS buffer solution with a pH in the range of 7.2-7.6 containing a non-ionic detergent at a concentration of 4 - 2% and NH4OH at a concentration of 0.2 - 0.08%, rinsing the tissue with a PBS buffer solution containing an antimicrobial agent, incubation in a deoxyribonuclease solution at a concentration of 0.001 to 0.003% (w/v), rinsing the decellularized tissues obtained with a PBS buffer solution containing an antimicrobial agent, wherein the non-ionic detergent is a compound with a molecular weight of 596 g/mol and additional steps of incubating the tissue in the solution PBS buffer with a pH of 7.2- 7.6 containing a non-ionic detergent at a concentration of 1.5-0.5% and NH4OH ata concentration of 0.2-0.08%, where the incubation is carried out at a temperature below room temperature for 36-48h, and incubation of the tissue in a PBS buffer solution with a pH of 7.2-7.6 containing a non- ionic detergent at a concentration of 0.75-0.25% and NH4OH at a concentration of 0.2-0.08%, where the incubation is carried out at a temperature below room temperature for 36-48h. Bioink containing decellularized tissue of animal origin.

PHOTOCURABLE COMPOSITION, THREE-DIMENSIONAL MODELING PRODUCT, AND DENTAL PRODUCT

Nº publicación: US2025215129A1 03/07/2025

Solicitante:

MITSUI CHEMICALS INC [JP]
MITSUI CHEMICALS, INC

Resumen de: US2025215129A1

A photocurable composition, comprising a photopolymerizable component and a photopolymerization initiator, further comprising a filler wherein: in a case in which a square plate shaped test piece A1 with a length of 10 mm, a width of 10 mm, and a thickness of 2 mm is produced, at least one square surface B1 having an area of 3 μm on a side in at least one cross section of the test piece A1 has a sea-island structure composed of island portions comprising the filler and having a length of 0.1 μm or more, and a sea portion, an average surface elastic modulus of the island portions is 9.0 GPa or more, an average surface elastic modulus of the sea portion is 4.5 GPa or more, an area of the island portions is from 1.0% to 15.0% with respect to an entire area of the surface B1.