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Méthode de fabrication d’hydrogel et ses utilisations

Resumen de: FR3172321A1

L’invention concerne un procédé de fabrication d’un hydrogel à partir d’au moins un polymère réticulable, le procédé comprenant les étapes suivantes : a) fournir une solution comprenant au moins un polymère réticulable et une oxydase, b) réticuler ledit au moins un polymère par l’oxydase et à l’aide d’H2O2 afin d’obtenir un hydrogel, où la source d’H2O2 lors de l’étape b) est fournie par un dispositif de génération d’un plasma froid. Figure pour l’abrégé : Figure 1

一种3D打印可降解仿生气管外支架及其制备方法

Resumen de: CN122604537A

本申请提供了一种3D打印可降解仿生气管外支架，包括高模量可降解材质外层以及低模量可降解材质弹性内层，外层与内层初始均为3D打印一体预制成型的板状形态，经热弯形围合后定型为适配气管壁的C形筒状，二者通过滑动结构实现相互不脱离的轴向滑动连接，内层可伴随气管壁轴向往复阻尼滑动与弹性复位以及径向与轴向伸缩耦合形变，同时采用内外壁双曲面结构，结合该功能分层构型、层间随动耦合形变的独创设计，可有效仿生人体气管天然生理曲度与力学特征；还提供了一种气管外支架制备方法，采用3D打印、热弯定型、滑动装配、静电纺丝修复层及无菌封装工艺，解决了现有技术支架力学性能矛盾、功能单一及量产受限等缺陷问题。

一种基于3D打印超透镜的颅内血管OCT成像导管

Resumen de: CN122604304A

本发明公开了一种基于3D打印超透镜的颅内血管OCT成像导管，属于医疗器械与光学成像技术领域。该导管包括：外壁封装套管、单模光纤、光学结构，集成于单模光纤远端端面，采用增材制造工艺直接构建。所述光学结构为3D打印光学结构或超透镜结构，被配置为实现光束的空间聚焦与传播方向的偏转，使出射光束以预设倾角从导管侧壁区域进行侧向发射，并补偿由导管聚合物材料及内部润滑介质所引起的像差。本发明通过将多功能光学元件直接集成于光纤末端，实现了紧凑化、一体化的光路设计，在≤0.7mm导管外径约束下同步实现高精度聚焦、可控侧向发射及多介质界面像差鲁棒补偿，显著提升了颅内远端血管OCT成像质量与临床适用性。

一种3d打印复合陶瓷修复义齿制备工艺

Resumen de: CN122608408A

本申请涉及陶瓷义齿增材制造技术领域，具体公开了一种3d打印复合陶瓷修复义齿制备工艺。包括以下步骤：S1、干燥、煅烧得到核－壳结构氧化锆粉末；将核－壳结构氧化锆粉末与蒙脱土纳米片、导电金属氧化物亚微米球混合，得到电活性陶瓷复合粉末；S2、制备光固化打印浆料；S3、将光固化打印浆料通过光固化3D打印成型，进行热脱脂处理以去除有机树脂，得到多孔素坯；S4、制备致密化着色义齿坯体；S5、清洗致密化着色义齿坯体，得到3D打印复合陶瓷修复义齿。本申请的复合陶瓷修复义齿可用于口腔个性化修复体的定制制作，其具有在低温条件下同步实现坯体致密化与全层深度梯度着色的优点。

一种富马酸酮替芬片及其制备方法

Resumen de: CN122604721A

本发明公开了一种富马酸酮替芬片及其制备方法，涉及药物制剂技术领域，所述制剂为环形结构且具有贯穿厚度的中心通孔，包括内核和包覆内核的pH敏感性外壳；内核由富马酸酮替芬原料药、协同助溶组分等经3D打印与梯度交联固化成型，外壳在口腔中抑制药物释放、在胃液中允许释放。制备方法包括打印墨水、复合凝固浴及梯度交联浴制备，3D打印成型，梯度交联固化，pH敏感层包覆及精准后处理。该制剂溶出速度快、脆碎度低、重量差异小、稳定性好且含量均匀，制备工艺精准可控，解决了传统制剂性能不佳的问题，适用于富马酸酮替芬的工业化生产。

バイオ複合材料組成物を作製および使用する方法

Resumen de: WO2025035104A2

Disclosed herein are methods of making and using biocomposite compositions comprising at least a polymeric component and a fiber component.

一种基于磁力驱动的分区式下颌与舌体前移矫治器及其制备方法

Resumen de: CN122604548A

一种基于磁力驱动的分区式下颌与舌体前移矫治器及其制备方法，包括由上矫治器和下矫治器组合形成的矫治器主体；所述矫治器主体包括利用负压使舌体前移以改善通气效果的前牙区矫治器和利用磁力给下颌提供下颌前移力的后牙区矫治器，前牙区矫治器包括用于防止口呼吸的弧状体，弧状体连接上矫治器和下矫治器形成一体式结构的矫治器主体；与现有技术相比，后牙区矫治器将磁铁应用于矫治器内部，通过调整相斥面角度及磁力大小，改变对牙列的应力分布，进行基于口颌系统生物力学仿真计算，获得最优的磁力大小和方向，为获得更加精准的磁力提供生物力学依据，以避免带来咬合关系改变和颞下颌关节紊乱等临床并发症，确保前移力的精准性与安全性。

3D打印抗氧化稀土氧化物掺杂的骨修复支架及其制备方法

Resumen de: CN122605000A

本发明属于骨修复领域，具体涉及3D打印抗氧化稀土氧化物掺杂的骨修复支架及其制备方法。包括以下步骤：以PVA水溶液为基体，加入分散剂聚丙烯酸铵，得到用于纳米粉体的粘合剂溶液；将nHAp、nβ‑TCP与nREO经球磨混合后，与所述粘合剂溶液混匀，制得可 3D 打印的膏状浆料；导入支架三维模型，设置打印参数，采用气压挤出式 3D 打印得到支架素坯；将支架素坯经室温干燥后，在空气氛围中高温烧结，得到无有机成分的骨修复支架。本发明的制备方法所需原材料种类少，制备工艺受环境影响小。加入稀土氧化物后，支架具有较好的抗压强度、生物相容性和抗氧化能力，在用于骨修复植入的基础上，还可以用作生物3D打印载细胞支架和载药支架等，具有广阔的应用前景。

一种脊柱矫形器设计方法

Resumen de: CN122604309A

本发明涉及脊柱矫形技术领域，特别是涉及一种脊柱矫形器设计方法。该方法通过脊柱矫形测量装置对患者顶椎区域施加梯度矫形力，测定额定矫形力与额定位移并建立实测数据库。同步采集患者 BMI、脊柱 Cobb 角、顶椎位置等关键参数，借助统计分析拟合得出多组参数间非线性二次函数关系，可快速推算出患者个性化矫正力学参数。将参数导入建模软件完成三维模型构建，再通过拓扑优化精简结构，最后利用 3D 打印技术完成矫形器制作。本发明建模精度高，所制矫形器贴合性好、矫正力度适配合理，兼顾使用安全性与矫治效果，制作流程简洁高效，可满足青少年特发性脊柱侧凸精准保守矫治的临床使用需求。

一种3D打印用聚乳酸/纳米羟基磷灰石复合线材及其制备方法与应用

Resumen de: CN122609030A

本发明涉及纳米复合材料技术领域，具体涉及一种3D打印用聚乳酸/纳米羟基磷灰石复合线材及其制备方法与应用。所述方法包括：S1、通过乳液溶剂挥发法制备不同平均粒径的聚乳酸/纳米羟基磷灰石复合微球；S2、将所述不同平均粒径的复合微球进行颗粒级配，获得级配原料；S3、将所述级配原料熔融挤出、牵引拉伸，得到复合线材。本发明通过复合微球化与颗粒级配相结合，有效实现了纳米羟基磷灰石在聚乳酸基体中的均匀分散，所得线材直径为1.75±0.03mm，纳米羟基磷灰石质量分数为3‑15%，断裂强度为37.52‑54.84MPa。该线材适用于FDM 3D打印，可用于制备骨修复支架，具有优异的生物相容性和力学性能。

一种光交联聚乙二醇水凝胶材料、制备方法及应用

Resumen de: CN122608907A

本发明公开了一种光交联聚乙二醇水凝胶材料、制备方法及应用，其中，光交联聚乙二醇水凝胶材料，包括组分A和组分B，其中，组分A为乙烯基化自组装三肽修饰的聚乙二醇，组分B为光引发剂；组分A和组分B在水相介质中光照交联形成光交联聚乙二醇水凝胶材。本发明提供的一种光交联聚乙二醇水凝胶材料、制备方法及应用，该水凝胶通过将乙烯基化自组装短肽引入聚乙二醇大分子链端，构建了独特的“物理‑化学”双模态交联网络，其前体体系具备高度灵敏且温度可控的“溶胶‑凝胶”可逆转变特性，光交联后，短肽自组装形成的纳米增强网络结构，实现了材料力学和韧性的同步提升。

一种兼具支撑的3D打印接骨板及其成型方法

Resumen de: CN122604477A

本发明属于匹配式3D打印支撑接骨板技术领域，公开了一种兼具支撑的3D打印接骨板及其成型方法。该接骨板为与截骨的撑开空白区角度匹配，并与骨面匹配式贴合，外形形态贴合骨骼轮廓，且具有支撑撑开空白区功能的三维的楔形支撑接骨板；该楔形支撑接骨板通过3D打印制成；楔形支撑接骨板包括：上表层上开设有多个用于促进轻量化设计的表层孔；表层孔的下部开设有经梯度变化孔径大于表层孔的用于提供强度力学支撑的内层孔；支撑接骨板本体的侧面开设有三维布设的多向斜向螺孔。本发明术前根据三维模型精确规划下肢力线与截骨撑开角度，结合个体化楔形支撑接骨板角度固定，保证力线矫正准确、支撑可靠，提高手术有效性与精准性。

ADDITIVELY-MANUFACTURED DEVICE AND METHOD

Resumen de: WO2026173937A1

A device includes an inner portion and an outer portion. The inner portion includes a plurality of first grains having a first size. The outer portion is disposed around the inner portion. The outer portion includes a plurality of second grains having a second size that is greater than the first size.

ANATOMICAL MODELS AND ASSOCIATED METHODS FOR EVALUATING COMPRESSION

Resumen de: AU2025220329A1

This disclosure relates to surgical systems, devices and methods for planning and implementing surgical procedures. The systems and methods disclosed herein may be utilized to establish physical anatomical models of anatomy. A compression feature may be utilized to evaluate compression between portions of the physical anatomical model.

INTEGRATED DECENTRALIZED IDENTITY-BASED SYSTEM FOR WEARABLE BODY-FLUID DETECTION, BIOCHEMICAL ASSAYING, EVIDENCE-CHAIN VERIFICATION, TRIAGE ROUTING, AND LIFELONG HEALTH MANAGEMENT WITH MULTI-MODAL CONFIRMATION

Resumen de: US20260243768A1

A wearable sensing system converts a home body-fluid sampling event into a clinically usable triage signal. A disposable wearable sensing article includes a directed microfluidic funnel, metering channel, conditioning layer, and biochemical assay core. A mobile module performs optical calibration, executes a stabilization protocol to generate a stability metric, and applies a multi-level quality gate before generating a cryptographically signed Trusted Event Package bound to a decentralized identity. The system routes verified triage outputs to medical endpoints and, when indicated, transmits a Minimum Necessary Emergency Bundle for emergency escalation. First and second embodiments include a nipple-discharge bra-liner and a cervicovaginal pad using consistent terminology and lock points. Exemplary network endpoints include medicalcenter.us, 120.us, bei.app, healthspac.com, medprc.com, beisignal.com, beipanel.com, and beiprint.com.

ECHOCARDIOGRAM CARDIAC MONITORING

Resumen de: US20260240516A1

Proposed concepts aim to provide schemes, solutions, concepts, designs, methods, and systems pertaining to cardiac monitoring of a subject which involves obtaining both echocardiogram data and a cardiac activity signal. In particular, embodiments aim to provide a method of cardiac monitoring in which a cardiac rhythm abnormality value is determined and used to generate supplementary data which can accompany the echocardiogram data to provide a comprehensive view of the cardiac behaviour of the subject during a monitoring time period.

Automated Creation of Stimulation Programs for Spinal Cord Stimulation

Resumen de: US20260241178A1

Systems for programming a neurostimulator for providing electrical neurostimulation to treat a patient are described. The systems are configured to allow a user, typically a clinician, to configure a source stimulation program. The system then uses the source program and/or other inputs to suggest additional stimulation programs (i.e., derivative stimulation programs) that may be created and used to program the patient’s neurostimulator. The other inputs may specify information about the patient, the patient's or clinician’s goals and priorities during the programming session, and/or information about the patient's neurostimulator, such as whether the neurostimulator uses a primary cell or rechargeable battery. The system can execute algorithms to use the source program and/or the other inputs to automatically create the derivative stimulation programs and to program the neurostimulator with those programs.

歯科支援装置、及びこのためのプログラム

Resumen de: JP7909089B1

【課題】補綴物を適切に作ることを可能にする歯科支援装置及びそのためのプログラムを提供する。【解決手段】患者の歯の画像データを取得し、当該画像データに基づいて歯を複数の領域に分割し、各領域ごとの代表色を算出し、予め定められた基準色体系を細分化して得られた基準色候補との色差を算出し、算出された色差に基づいて該患者に適合する補綴物又は矯正シミュレーションのための色を特定する処理を実行する。【選択図】図１

THERMOREGULATED PROSTHETIC LINERS

Resumen de: WO2026170317A1

The disclosure discloses prosthetic liners that address breathability and comfort issues while maintaining proper fit and functionality. A prosthetic liner assembly is provided. It includes a prosthetic liner and a skin-proximal interface. The prosthetic liner defines a proximal end and a socket-mounting distal closed end and delimiting a member-receiving cavity. It includes a first lattice structure forming a body region of the prosthetic liner extending from the proximal end toward the distal end, and a second structure forming the distal closed end. The skin-proximal interface is removably insertable into a member-receiving cavity of the the prosthetic liner and includes a fabric body covering at least partially an inner surface of the prosthetic liner delimiting the member-receiving cavity when the skin-proximal interface is inserted into the prosthetic liner.

Operationsschablone und Verfahren zur Gestaltung und/oder Herstellung einer Operationsschablone

Resumen de: DE102025105586A1

Die Erfindung betrifft eine Operationsschablone (OS) zur Anwendung im Bereich eines Schläfenbeins, insbesondere im Rahmen einer Durchführung einer radikalen Mastoidektomie, umfassend einen Schablonenkörper (SK) mit einer Außenseite (AS) und einer Innenseite (IS), auf welcher der Schablonenkörper (SK) schläfenbeinseitig aufzulegen ist. Der Schablonenkörper (SK) ist mit einem von der Außenseite (AS) zu der Innenseite (IS) verlaufenden Durchbruch (D) durchsetzt, wobei der Durchbruch (D) bei dem Schablonenkörper (SK) mit einem Außenrand (AR) definiert ist, welcher einer Außenkontur eines zu entfernenden Knochenteils des Schläfenbeins (SB) entspricht.

METHODS AND SYSTEMS FOR PREVENTING CARDIOMETABOLIC DISEASES

Resumen de: US20260245735A1

0000 Some embodiments provide for a method for identifying an intervention for a subject in furtherance of preventing development of cardiovascular disease in the subject, the method comprising: obtaining cardiometabolic health data for the subject; determining, using at least some of the cardiometabolic health data, a first trained machine learning (ML) model and for each of multiple time intervals, one or more measures of risk that the subject develops cardiovascular disease to obtain multiple measures of risk; determining, using the multiple measures of risk that the subject develops cardiovascular disease and at least one second trained ML model, benefit of administering to the subject one or more therapeutic interventions designed to reduce risk of cardiovascular disease by targeting one or more modifiable causes of the cardiovascular disease; and identifying, using the determined benefit of administering the therapeutic intervention(s), at least one therapeutic intervention to recommend being administered to the subject.

TOOTH RETAINING DEVICE AND MANUFACTURING METHOD THEREFOR

Resumen de: WO2026173324A1

Disclosed is a tooth retaining device. The tooth retaining device, which is manufactured by a 3D printer on the basis of 3D scan data of a patient's dental structure, may comprise: a shape part including surface contact parts attached to lingual tooth surfaces to correspond to the shape of at least one tooth of an anterior teeth part, and protrusion parts positioned between the surface contact parts and facing the interdental spaces; and both end parts positioned at both ends of the shape part and attached while facing occlusal surfaces of premolars.

ORTHODONTIC APPLIANCE SYSTEMS AND METHODS OF MAKING SAME

Resumen de: US20260240625A1

0000 An orthodontic appliance system for orthodontic treatment of teeth. The system includes a template with a cavity. An attachment is removably received in the receptacle and has a surface including a bonding surface. A method of manufacturing includes constructing a scaffold assembly including a base and placing a template in contact with the scaffold assembly. The method includes inserting the attachment into the receptacle. During separating, the attachment remains coupled to the template in the receptacle. A method of manufacturing includes providing a mold of the patient's teeth. The mold including at least one projection and a through-passage. The method includes placing a container of dental composite in fluid communication with the through-passage, placing a template over the at least one projection, injecting dental composite from the container through the through-passage and into the receptacle, and removing the template from the at least one projection with the filled receptacle.

NOVEL PROCESS

Resumen de: US20260242736A1

0000 The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained With the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

TRACKING AND MONITORING RESOURCE USAGE BY SUBJECTS

Nº publicación: US20260245000A1 20/08/2026

Solicitante:

LIFELENS TECH INC [US]
LifeLens Technologies, Inc.

Resumen de: US20260245000A1

An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain resource usage tracking data from one or more sensing devices associated with a subject, the resource usage tracking data characterizing availability of one or more resources utilized by the subject. The at least one processing device is also configured to determine, based at least in part on the received resource usage tracking data, one or more resource usage metrics for the one or more resources, and to generate, based at least in part on the determined one or more resource usage metrics, one or more feedback signals. The at least one processing device is further configured to transmit the generated one or more feedback signals to at least one additional processing device.