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カップリング部材、流路接続機構およびインクジェット記録装置

Resumen de: US2025269656A1

A coupling member includes a valve housing and a hollow movable valve. Relative to the valve housing, the hollow movable valve is positionally displaced in an axis direction between a position in a connected state where the coupling member is connected to another coupling member and a position in a disconnected state where the coupling member is disconnected from the other coupling member, thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap is generated between a prescribed part of the hollow movable valve and the valve housing in a radial direction. The hollow movable valve has a circulation opening penetrating through the prescribed part in the radial direction.

一种光热抗菌PETG浆料的牙齿隐形矫正器制备方法

Resumen de: CN120585487A

一种光热抗菌PETG浆料的牙齿隐形矫正器制备方法，涉及本发明一种牙齿隐形矫正器制备方法，以PETG的热塑性流动性温度转变为导向点，乳液与PETG形成局限性空间内的稳态化学键合，进而强化隐形矫正器本征机械性能，通过粘流态PETG、抗菌乳液、光固化树脂之间的层次化官能团间的交互反应形成高透明、高机械、高抗菌的PETG浆料，进一步通过光固化打印技术制备出隐形矫正器，进一步通过高压分散工艺导致抗菌材料在透明硅溶胶中的三维稳态分布并强化界面键合作用。延长隐形矫正器使用寿命，维护口腔健康，实现口腔医疗领域的高价值转化。

一种骨水泥材料及制备方法和用途

Resumen de: CN120586154A

本发明公开了一种骨水泥材料及制备方法和用途，成分为聚酯高分子PEGS‑OH和磷酸钙盐CPC的骨水泥原料中掺杂骨形态发生蛋白‑2，在交联剂的作用下制得所述骨水泥材料，所述骨水泥材料在添加极少量的骨形态发生蛋白‑2情况下即可获得缓释平稳好、成骨活性高等性能的骨水泥材料。

一种适用于制造器官尺度结构的生物3D打印方法

Resumen de: CN120586157A

本发明公开了一种适用于制造器官尺度结构的生物3D打印方法，包括：将细胞沉淀与水凝胶前体溶液混合制备可用于打印的生物墨水；以生物墨水为原料，利用投影式生物3D打印机打印预设的器官尺度结构；所述水凝胶前体溶液包括水凝胶前体、光引发剂、光吸收剂、密度调节剂、胰酶抑制剂和生理pH缓冲液。由该打印方法制得的器官级3D结构具有精细的打印分辨率和优异的细胞活力，显示了其在组织工程中的潜在适用性；该打印方法具有所需设备简单、操作简便、可快速且批量化制备和成本效益好的优点。由上述方法制得的单取向的器官级3D结构可应用于组织工程与再生医学研究中。

一种多功能儿童扩弓器及其制造方法

Resumen de: CN120585489A

本发明专利公开了一种多功能儿童扩弓器及其制造方法，其特征在于，所述多功能儿童扩弓器包括上颌牙套、下颌牙套和胶粘剂，所述上颌牙套外侧咬合面设有上凸台，所述下颌牙套外侧咬合面设有下凸台，所述胶粘剂位于上凸台和下凸台中间。本发明通过胶粘剂粘结上颌牙套和下颌牙套得到一体式结构，结构简单，且通过设置1‑4mm高度上凸台和下凸台来调节双颌距离，使儿童扩弓器具有良好的佩戴舒适度。此外，本发明的儿童扩弓器可用于儿童早矫扩弓、止鼾和防磨牙。本发明中一种多功能儿童扩弓器的制造方法，工序简单，成本低。本发明具有很高的实用价值，值得大范围推广应用。

兼具抗肿瘤与骨修复的免疫调节支架及其制备方法与应用

Resumen de: CN120586151A

本发明提供了一种兼具抗肿瘤与骨修复的免疫调节支架及其制备方法与应用，属于组织工程植入材料技术领域。本发明在富醛基3D打印磷酸钙骨架上组装含有MCSF/CSF‑1R和CD47/SIPRɑ通路阻断药物共递送系统的HBC网络，开发了一种能够分阶段激活吞噬肿瘤细胞的巨噬细胞并促进骨再生的治疗性植入物。该植入物显示出与单核细胞/巨噬细胞表面的有效结合，同时显著抑制了骨髓来源单核细胞的M2极化，并增强了巨噬细胞对肿瘤细胞的吞噬能力。本发明的共递送系统负载的两种药物能够发挥协同作用高效抗肿瘤；分解的递送载体能促进骨再生。在体内肿瘤治疗模型中，该治疗支架显著减少了局部M2巨噬细胞，并抑制了肿瘤生长。在体内组织再生模型中，该治疗支架促进了均匀的骨生长。

用于经由装载了API的组织穿透器递送药物的装置和方法

Resumen de: WO2024163828A1

A drug delivery device includes at least one tissue penetrating member configured to embed into tissue, the at least one tissue penetrating member including at least one cavity formed beneath an outer surface of the at least one tissue penetrating member, the at least one cavity having a depth from the outer surface and a width in a direction that is orthogonal to a direction of the depth from the outer surface, and at least one opening in the outer surface that communicates with the at least one cavity so that at least one API loaded into the at least one cavity can be absorbed from the at least one cavity into the tissue, wherein a width of the at least one opening is less than the width of the at least one cavity.

VASCULARIZED BONE ORGANOID AND CONSTRUCTION METHOD THEREFOR

Resumen de: WO2025179532A1

Provided are a vascularized bone organoid and a construction method therefor. By combining a suspension-based three-dimensional (3D) bioprinting method, a cell-laden printing strategy, and a sacrificial bioink material, a vascularized bone organoid model containing a hollow vascular network is constructed. The vascularized bone organoid model has excellent structural stability, mechanical properties, growth and development capability, and osteogenic capability, involves simple selected materials and fabrication process, implements engineered stable production, allows for long-term co-culture of cells for 3D cultivation, and has high applicability and research potential.

PREPARATION METHOD FOR 3D BIOPRINTED TRACHEAL SUBSTITUTE LOADED WITH EPCS

Resumen de: LU509884B1

The invention provides a preparation method for a 3D bioprinted tracheal substitute loaded with EPCs, which includes steps of: S1, preparing a complete decellularized tracheal extracellular matrix free of immunogenicity; S2, preparing an LAP-NC-dtECM hydrogel; S3, isolating and culturing EPCs; S4, preparing an LAP-NC-dtECM bioprinting ink loaded with EPCs; S5, preparing the 3D bioprinted tracheal substitute loaded with EPCs. Combining an acellular trachea to retain complete natural extracellular matrix components, cell nuclei and immune substances are effectively removed so that the invention has excellent characteristics such as being free of immunogenicity, good biocompatibility and the ability to effectively induce angiogenesis in vivo. The invention is prepared into a hydrogel and added with bone marrow EPCs to prepare a printable bioprinting ink, so as to reconstruct a biomimetic tracheal stent with good biomechanical properties and angiogenesis properties in combination of the 3D bioprinting technology.

SOLID DOSAGE FORM PRODUCTION

Resumen de: US2025275927A1

The present invention provides methods of preparing solid dosage form, particularly pharmaceutical dosage forms, using extrusion and 3D-printing, as well as the solid dosage form itself, the compositions used to make said items, uses of the solid dosage forms, and containers used in their preparation.

IMPLANTS HAVING BONE GROWTH PROMOTING AGENTS AND METHODS OF USING SUCH IMPLANTS TO REPAIR BONE STRUCTURES

Resumen de: US2025275856A1

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants may be coated with or include fibers or particles to enhance bone growth around and through the implant.

DENTAL CROWN MODEL GENERATION METHOD AND DENTAL CROWN MODEL GENERATION SYSTEM

Resumen de: US2025275838A1

The present invention provides a dental crown model generation method and a dental crown model generation system. The method includes: retrieving preset dental shape data including multiple geometric features based on the target position of the treated tooth; adjusting the preset dental shape using rotation, stretching, and translation parameters to obtain the adjusted geometric features; scoring the matching degree between the adjusted geometric feature and multiple conditional operations; performing weighted calculations on the scores to obtain a denture score; if the denture score is below a threshold score, inputting the denture score into a parameter correction artificial intelligence unit to obtain new rotation, stretching, and translation parameters, and continuing the adjustment until the denture score exceeds the threshold score; and using the dental shape corresponding to the final parameters as the final dental crown model for the patient.

SYSTEMS AND METHODS FOR PRINTING A CORE FIBER

Resumen de: US2025276489A1

A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

BIO-INSPIRED NEEDLE FOR CONTROLLED RELEASE

Resumen de: US2025276164A1

A micro-needle (MN) patch is formed as an array of 3-D bioprinted structures having a relatively hard planar base with multiple water sensitive barbed tips extending therefrom. The barbed tips are formed from a polymer material configured to exhibit reversible shrink-swell volume change in response to surrounding humidity to facilitate skin penetration under the shrinkage conditions and long-term adhesion when swelling in skin tissues.

SYSTEMS AND METHODS FOR RAPID LIQUID BIOPRINTING

Resumen de: WO2025181649A1

Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.

METHOD FOR PRODUCING ORGANOIDS, ORGANOIDS PRODUCED WITH THIS METHOD, AND USE THEREOF

Resumen de: WO2025181738A1

A method for producing organoids, wherein: a hydrogel containing cells and optionally a photoinitiator is subjected to a bioprinting process at a temperature within a range of 20-30°C, a pressure within a range of 40-75 kPa, and a constant extrusion rate of 10 mm/s, wherein the printed hydrogel is directed into a vessel containing oil, and then the resulting hydrogel capsule in an oil layer is transferred to a sieve and washed with hexane and a cell medium. Organoids produced with this method, and use thereof.

FEM ANALYSIS FOR THE PRODUCTION OF DENTAL RESTORATIONS

Resumen de: EP4609822A1

Die vorliegende Erfindung betrifft ein Verfahren zum Aufbauen einer dentalen Restauration, mit den Schritten eines Bereitstellens (S101) eines dreidimensionalen Datensatzes, der die räumliche Form der dentalen Restauration und eine räumliche Verteilung zumindest eines Herstellungsmaterials innerhalb der dentalen Restauration angibt; eines Simulierens (S102) einer räumlichen Spannungsverteilung innerhalb der dentalen Restauration bei einer vorgegebenen Belastung auf Basis des dreidimensionalen Datensatzes; und eines Veränderns (S103) des dreidimensionalen Datensatzes auf Basis der simulierten Spannungsverteilung.

Apparatus and method for 3D printing

Resumen de: GB2638786A

3D printing of solid-dosage-forms. A printhead comprising one of an integrated powder dispenser or an integrated peristaltic pump 11, where the printhead may be interchangeable and may comprise a multi-tip array. A 3D printer comprising one or more of the printheads. The peristaltic pump may comprise a thermostatic peristaltic pump and tubing 13 for pumping at up to 160 °C, a temperature controlled chamber 12 for storing semi-solid material, and may comprise dispensing tips 15 for simultaneous printing of multiple items. 3D printing apparatus comprising the 3D printer and a build platform with integrated capsule holders and/or moulds. 3D printing apparatus comprising a conveyer belt and balance. Methods of manufacturing solid-dosage-forms comprising use of the 3D printer to print semi-solid material at up to 160 °C, fill capsules or moulds, or print multiple items simultaneously.

CONTINUOUS MID-AIR 3-DIMENSIONAL PRINTING FOR PHARMACEUTICAL DOSAGE FORMS

Resumen de: WO2024092237A1

Described are continuous manufacturing methods using 3D printing or any similar additive manufacturing technology to produce pharmaceutical dosage forms or pharmaceutical delivery devices. Manufacturing methods using hot-melt extrusion to fabricate filaments for fused deposition modeling (FDM) based 3D printing are disclosed. Methods using FDM based 3D printing to fabricate printed products suitable for pharmaceutical delivery purposes are disclosed. The printed products may have various shapes and configurations.

CURABLE COMPOSITIONS COMPRISING A POLYMERIZABLE REACTIVE DILUENT FOR FABRICATION OF ORTHODONTIC APPLIANCES

Resumen de: US2024191006A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

FEM ANALYSIS FOR THE PRODUCTION OF DENTAL RESTORATIONS

Resumen de: EP4609823A1

Die vorliegende Erfindung betrifft ein Verfahren zum Aufbauen einer dentalen Restauration, mit den Schritten eines Bereitstellens (S101) eines dreidimensionalen Datensatzes, der die räumliche Form der dentalen Restauration und eine räumliche Verteilung zumindest eines Herstellungsmaterials innerhalb der dentalen Restauration angibt; eines Simulierens (S102) einer räumlichen Spannungsverteilung innerhalb der dentalen Restauration bei einer vorgegebenen Belastung auf Basis des dreidimensionalen Datensatzes; und eines Veränderns (S103) des dreidimensionalen Datensatzes auf Basis der simulierten Spannungsverteilung.

細胞微小区画における細胞外マトリックス代替物

Resumen de: CN119731304A

The present invention relates to a clinically usable "GMP" compliant cell microcell comprising at least: a. A cellular layer, b. An outer hydrogel layer, and c. A fibrin web disposed between the outer hydrogel layer and the cellular layer. The invention also relates to a method for producing such a microcompartment and to the use of a kit for producing a cell microcompartment comprising a fibrinogen solution and a thrombin solution.

一种基于液相烧结和离子取代同时增强力学性能和生物学性能的3D打印白磷钙石复合支架的制备方法

Resumen de: CN120571076A

本发明公开了一种基于液相烧结和离子取代同时增强力学性能和生物学性能的3D打印白磷钙石复合支架的制备方法。该方法采用桌面级DLP打印技术作为成型工艺，以白磷钙石作为基体材料，通过Li3PO4掺杂引入液相烧结机制与离子取代反应的协同作用，可同步调控支架的微观结构和物相组成，最终实现力学性能、降解特性及生物活性的综合提升。本发明为骨缺损修复过程中磷酸钙类陶瓷力学性能不足的问题提供了一种有前景的解决方案。

用于产生气溶胶的声学流体装置

Resumen de: CN120572739A

本发明涉及微系统技术领域，并涉及一种可用于打印装置的声学流体装置,其具有小的尺寸并且可以集成到用于沉积气溶胶的设备中并且通过简单的结构实现具有可调节气溶胶特性的定向气溶胶流。该任务通过一种声学流体装置解决，该声学流体装置至少包括至少一个气溶胶出口部件和至少一个保持部件以及至少各一个用于气体、液体和热量的供用管路和/或排放管路、至少一个电管路和/或电信号管路和至少一个高频电信号管路以及至少一个用于热量传输的部件和至少一个温度传感器和至少一个微声学部件以及至少一个用于传输高频信号的部件和至少一个用于液体传输的部件和至少一个传输气体部件以及至少一个用于定位和/或机械紧固的部件。

Oral device to inhibit mastication and ingestion of solid food

Nº publicación: US12403025B1 02/09/2025

Solicitante:

MOJAVER MAHNAZ NINA [US]
Mojaver Mahnaz Nina

Resumen de: US12403025B1

The present invention is oral device that inhibits mastication and ingestion of solid food while minimizing intrusiveness and discomfort in other oral activities. This device is ideal for individuals following an all-liquid diet without relying on willpower alone. The oral device allows a full range of motion of the jaw and the wearer keeps the ability to open and close the mouth, allowing all oral functions other than chewing and swallowing solid food. In various embodiments of the invention, the oral device comprises a set of retainers worn over teeth or retainer bars bonded to, or integrated as part of the retainers. A set of flexible mastication barriers coupled to the retainers or retainer bars and extending from mandible to the maxilla on the lingual side of the mouth inhibit the movement of solid food to the occlusal surfaces of the posterior teeth for chewing. An artificial intelligence platform is implemented to improve fabrication of the oral device and predict and eliminate undercuts in the retainers or retainer bars.