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TRANSCATHETER DELIVERABLE PROSTHETIC HEART VALVES AND METHODS OF DELIVERY

Resumen de: AU2025202301A1

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

SYSTEMS AND METHODS FOR GENERATING PATIENT-SPECIFIC IMPLANTS FOR ANATOMICAL STRUCTURES OF PATIENTS

Resumen de: US2025120816A1

Embodiments for generating patient-specific implants for anatomical structures of patients are disclosed. One embodiment includes a method that includes receiving image data of an anatomical structure of a patient, where the image data indicates a fracture site associated with the anatomical structure; receiving manipulation data associated with manipulation of one or more parameters associated with the fracture site in a virtual reality environment; visualizing a three-dimensional (3D) model of the anatomical structure based on the image data, the one or more parameters, and the manipulation data, where the 3D model is visualized in a 3D space; generating a set of instructions for a printer based on the 3D model, and controlling the printer for generating a 3D printed model of the anatomical structure based on the set of instructions. The 3D printed model is configured to receive an implant, such that the implant is contoured to match the fracture site.

SPINAL INTERBODY FUSION DEVICE

Resumen de: US2025120822A1

A bellows shaped spinal implant, comprising an upper plate, a lower plate and a bellows shaped shell extending between and joining the upper and lower plates. The bellows shaped shell is formed of titanium or an alloy comprising titanium and includes a wall extending therearound that defines a hollow interior. The wall has a thickness in the range of 0.5 mm to 1.0 mm to provide for radiographic imaging through the wall. The wall is angled or curved inwardly or outwardly between the upper and lower plates to provide stiffness mimicking the stiffness properties of a similarly sized polyetheretherketone (PEEK) implant. The upper and lower plates each comprise porous contact regions including a three-dimensional gyroid lattice structure defined by a plurality of struts and pores in communication with the hollow interior. The outer surfaces of at least a portion of the struts may comprise a laser ablated textured surface.

System For Forming A Patient Specific Surgical Guide Mount

Resumen de: US2025120727A1

A system for making a resection of a bone having localized anatomical surface features prior to resection, comprising: a resection guide locator including a body, the body including opposing medial and lateral wings extending outwardly from the body, the body defining a recess being a socket defined by an annular wall, the annular wall including an upper wall, a lower wall, a resection guide having a body defining a resection slot, at least a portion of the resection guide body sized and configured to be received within the recess defined by the resection guide locator.

BIOINK FOR REPRODUCIBLE PRODUCTION OF 3D TUMOR TISSUE SCAFFOLDS

Resumen de: US2025122468A1

The present invention relies on the discovery that certain proteins are enriched in the tumor microenvironment of different types of tumors and subgroups of tumors but not in others and that such proteins can be used as components of bioinks. The bioinks can be used in production of reproducible tumor type-specific 3D scaffolds to provide tumor type-specific in vitro models for various cancer research applications.

弾性歯列矯正器具

Resumen de: CN112055571A

Provided herein is an orthodontic aligning appliance for moving tooth or teeth of a patient and methods of making and using the same. The orthodontic aligning appliance is formed of a material ("appliance forming material") having an elastic material in an amount that imparts to the aligner elastic properties such that the appliance exerts a continuous aligning force on a tooth or teeth, the elastic material is a material other than polyester, and the elastic material accounts for all or substantially all the elastic properties of the appliance.

３Ｄプリント医薬品の調製プロセス

Resumen de: CN119212681A

The invention relates to a method for producing a 3-D printed pharmaceutical product.

SYSTEM AND METHODS FOR MANUFACTURING IN VITRO HIGH PERFORMANCE WOOD

Resumen de: US2025122469A1

An exemplary embodiment of the present disclosure provides a method for generating in vitro wood. The method can comprise culturing a plurality of wood forming plant cells; encapsulating the plurality of wood forming plant cells in one or more hydrogels; developing one or more bioinks; and generating structures comprising the one or more bioinks. The one or more bioinks can comprise one or more plant cell culture medium components. In an exemplary embodiment, the plurality of wood forming plant cells are cambial meristematic cells, and can include genetically modified plant cells. The one or more bioinks can be configured to be loaded into a bioprinting system, which can generate the structures via an extrusion based method. The generated structures can be incubated to induce wood formation, monitored, and tested for superior material properties.

ADDITIVELY-MANUFACTURED COMPOSITE ROD FOR SPINAL INSTRUMENTATION

Resumen de: US2025121117A1

A composite rod for spinal instrumentation may include a metal rod forming an inner core; and a composite polymer derived from a hybrid of PEEK and negatively (−) charged zeolite molecules forming an outer coating around at least a top portion of the inner core. The inner core and the outer coating each have a variable thickness, thereby forming a composite rod having a uniform overall thickness. The composite rod may be 3D-printed and may optimize fusion via rod stiffness and osteoconductive matrix spanning the levels fused, while maximizing pre-operative customization and surgeon intra-operative flexibility.

ADJUSTABLE SECUREMENT DEVICE FOR ENDOTRACHEAL TUBE

Resumen de: US2025121147A1

The present disclosure generally relates to devices, and related methods of treatment using the same, for securing an endotracheal tube (commonly abbreviated as “ETT”) or other medical line to a patient, and more particularly to infants, babies in a neonatal unit, small children, etc.). The disclosure also relates to techniques and devices to remove the presence of unplanned extubations. In an exemplary embodiment, as taught in the present disclosure, a device may be used to secure an endotracheal tube to a small child or newborn infant such that the device may be configured to adjust the grip of the endotracheal tube to achieve optimal securement and stabilization of the endotracheal tube.

SYSTEMS, METHODS, AND DEVICES FOR MICROSTRUCTURE CHARACTERIZATION

Resumen de: US2025125018A1

Systems, methods, and devices disclosed herein include three-dimensional bioprinting technologies which produce cell scaffolds with a high degree of complexity and precision. A bioprinting ink mixture can be formed with coated gold nanoparticles in an alginate-gelatin solution. Upon bioprinting a 3D scaffold microstructure from the bioink mixture, an imaging procedure is performed on the 3D scaffold microstructure using the coated gold nanoparticles as a contrasting agent. A microstructure characterization is determined from the imaging procedure, and a virtual 3D reconstruction of the microstructure characterization can be generated for presentation on a graphical user interface (GUI) of a computing device. These techniques can be used to determine whether the resultant internal core of the microstructure properly mimics the architecture of the native tissue extracellular matrix (ECM) present in-vivo by determining the degree of pore interconnectivity which can improve cell distribution, attachment, and growth in the 3D scaffold microstructure.

骨補填材の製造方法

Resumen de: JP2025063999A

【課題】骨欠損部に応じた形状等、所定形状の骨補填材を安価に製造可能な骨補填材の製造方法を提供する。【解決手段】骨補填材の製造方法は、β－リン酸三カルシウムを主成分とする骨補填材の製造方法である。骨補填材の製造方法は、リン酸一水素カルシウム二水和物、水酸化カルシウム及び光硬化性樹脂組成物を含む光硬化３Ｄプリント用スラリーを用い、光造形３Ｄプリンターで所定の形状に造形する造形工程と、造形された造形体を焼成する工程と、を含む。【選択図】図２

押し潰し可能なチューブ状ダイアフラムを有する医療手順用イントロデューサシースバルブ

Resumen de: JP2023155490A

To provide improved introducer sheath valves for use in endovascular, laparoscopic and other surgical procedures.SOLUTION: The invention relates to a valve used in medical procedures. More specifically, the invention relates to an introducer sheath valve used in minimally invasive and conventional surgical procedures. The valve may accommodate a wide range of surgical implement diameters, shapes and multiple implements without imposing the high frictional forces of known valves.SELECTED DRAWING: Figure 1

A METHOD AND A COMPUTER PROGRAM FOR PERFORMING SCAFFOLD DESIGN OPTIMIZATION TOWARDS ENHANCED BONE HEALING, AND A METHOD TO MANUFACTURE A SCAFFOLD

Resumen de: US2025124195A1

The invention concerns a method, in particular a computer-implemented method, for performing scaffold design optimization (h) towards enhanced bone healing, the method comprising the steps of a) Inputting a set of parameters comprising information about a geometry and a material of a scaffold (3) to a computational model, the computational model comprising a finite element model and a mechano-biological computational model, wherein the finite element model determines and provides a set of mechanical information data for the set of parameters to the mechano-biological computational model, wherein the mechano-biological computational model determines from the set of mechanical information data a regenerated bone volume; b) Determining a plurality of regenerated bone volumes for a plurality of sets of parameters according to step a), such as to generate a scaffold bone data associating the regenerated bone volume with the corresponding set of parameters; c) Determining a computational surrogate model consisting of an analytical expression configured to associate the regenerated bone volumes with the sets of parameters from the scaffold bone data; and d) Determining from the computational surrogate model an optimum set of parameters for which the computational surrogate model puts out a maximum regenerated bone volume. The invention also concerns a computer program and a method to manufacture a scaffold (3).

SYSTEMS AND METHODS FOR MICROMANUFACTURING AND BIOPRINTING IN A MICRO GRAVITY ENVIRONMENT THEREOF

Resumen de: WO2025080715A1

The system, methods, and uses of micromanufacturing materials, scaffolds, and living tissues in microgravity environment that is found in space such as Low-Earth-Orbit, on a spacecraft in-transit between celestial bodies, or on other celestial bodies such as the Moon or Mars.

歯科用硬化性組成物

Resumen de: CN118984693A

The present invention relates to a curable composition for dental purposes. The invention is characterized in that the composition comprises a core-shell impact modifier and 0.1 to 10% by weight of a binder based on long-chain monofunctional (meth) acrylates, wherein the ester groups have carbon chains having at least 3 carbon atoms. The invention also relates to the use of the composition as a dental material or a dental adjuvant, to a dental product made from the composition and to a method for producing the dental product.

SYSTEMS AND METHOD FOR ADDITIVE MANUFACTURING OF DENTAL DEVICES USING PHOTOPOLYMER RESINS

Resumen de: EP4537787A2

Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.

MEDICAL DEVICE BASED ON BIOCERAMICS, ITS USE AS A SYNTHETIC BONE GRAFT AND PROCESS FOR THE PREPARATION THEREOF

Resumen de: AU2023282947A1

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: WO2023244797A1

Disclosed herein are devices and methods of making and use thereof.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: WO2023244821A1

Disclosed herein are devices and methods of making and use thereof.

リテーナの製造

Resumen de: MX2024011924A

The invention relates to a process for manufacturing a retainer, said process comprising the following steps: a) at an update time, after the end of an orthodontic treatment, acquiring at least one two-dimensional image of at least one portion of a dental arch of a user, called the "updated image", by means of an image-acquiring apparatus; b) generating a digital three-dimensional model representing the dental arch of the user, called the "updated model", based on the updated image; c) designing, based on the updated model and preferably by computer, a retainer suitable for keeping teeth in their configuration at the update time; d) manufacturing the retainer.

一种口腔正畸改良式3D打印横腭杆

Resumen de: CN222752154U

本实用新型公开了一种口腔正畸改良式3D打印横腭杆，涉及口腔正畸器械技术领域。包括横腭杆主体，横腭杆主体的中部开设有安装孔，安装孔中活动安装有种植钉，横腭杆主体的左右两端中部设置有凸块，凸块的上下两端安装有活动块，活动块的中部贯穿有固定栓，活动块的圆周表面安装有固定块，固定块远离活动块的一端安装有固定板，固定板远离固定块的一侧中部安装有连接块，连接块远离固定板的一端安装有固定半环，固定半环的上下两端中部安装有连接环，连接环的圆周表面安装有固定弓丝，凸块的外侧中部安装有固定柱，固定弓丝远离连接环的一端安装在固定柱的圆周表面上，固定板靠近凸块的一侧中部开设有固定孔，固定柱活动安装在固定孔中。

一种激光粉末床熔化制备可降解镁合金血管支架的方法

Resumen de: CN119819946A

本发明适用于增材制造技术领域，提供了一种激光粉末床熔化制备可降解镁合金血管支架的方法，包括以下步骤：按照以下质量百分比称取原料：Sr 1‑3%，Zr 0.5‑1.5%，Bi 0.2‑1%，Si 0.5‑2%，Ti 0.1‑0.5%，余量为Mg，熔炼形成均匀的液态合金，再使用高压氩气喷射液态合金，使其冷却形成粉末颗粒，筛选得到镁合金粉末；根据血管的尺寸和血流特性，设计支架的壁厚和孔隙结构；将镁合金粉末铺设在基板上，根据支架的结构设计激光扫描路径，采用层间扫描，制备镁合金支架；对镁合金支架进行抛光处理，清洗后烘干，再将支架进行氟化处理，再清洗吹干。本发明不影响镁合金材料的生物相容性和力学强度的前提下，成功制备出具有良好生物降解特性的血管支架。

一种钛基植入体表面双重药物释放系统及其制备方法与应用

Resumen de: CN119818720A

本发明属于医用材料技术领域，涉及一种钛基植入体表面双重药物释放系统及其制备方法与应用。包括钛基植入体和贴合在其表面的水凝胶层，钛基植入体表面为纳米管阵列结构，钛基植入体与水凝胶层之间设有氧化锌纳米颗粒和上转换发光材料颗粒，水凝胶层内装载MgO2纳米颗粒；其中，所述上转换发光材料颗粒的材质为NaYF4:Yb3+,Er3+，水凝胶层由明胶‑海藻酸钠水凝胶构成。本发明提供的钛基植入体表面双重药物释放系统不仅能够实现不同药物的装载，可以用于治疗多种疾病，而且具有较好的时序控制效果，作用时间长，成本低，具有广阔的应用前景。

An apparatus for automatically manufacturing cosmetics

Nº publicación: KR20250050445A 15/04/2025

Solicitante:

주식회사제이케이아이앤씨

Resumen de: KR20250050445A

본 발명의 일 실시예에 따른 화장품 자동 제조 장치는, 화장품을 구성하는 서로 다른 종류의 재료 중 제 1 재료를 수용하는 수용 용기가 안착되도록 마련되는 조제 유닛; 화장품을 구성하는 서로 다른 종류의 재료 중 제 2 재료를 적어도 하나 이상 수용하며, 상기 조제 유닛에 안착된 수용 용기 측으로 상기 제 2 재료를 공급하도록 구비되는 카트리지 유닛; 상기 조제 유닛 및 카트리지 유닛을 통해 상기 제 1 재료와 제 2 재료가 혼합된 1차 혼합물을 수용하는 수용 용기가 안착되도록 마련되며, 상기 1차 혼합물에 대한 교반을 진행하여 화장품을 제조하는 교반 유닛; 및 상기 화장품 제조 장치의 구동 제어를 진행하기 위한 제어 신호를 생성하며, 상기 화장품을 구성하는 재료와 관련된 정보인 재료 정보를 생성하는 제어 유닛;을 포함하는 것을 특징으로 한다.