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ARRANGEMENT AND METHOD FOR MANUFACTURING A PLURALITY OF ORTHODONTIC APPLIANCES

Resumen de: MX2025009432A

The invention relates to an arrangement for manufacturing a plurality of orthodontic appliances (1) in parallel, comprising an additive printing machine (2) comprising a build platform (4) and configured for additively manufacturing a plurality of teeth models (9) in parallel, a plurality of plates (6) each configured for teeth model printing by the additive printing machine (2), whereby each plate (6) comprises a unique machine-readable identifier (13) and each plate is detachable and precisely fixed to the build platform (4), and a thermoforming machine (10) configured for thermoforming a thermoformable material (11) over the plurality of teeth models (9) for receiving the plurality of orthodontic appliances (1).

一种基于载细胞近场直写打印的三层神经导管及其制备方法和应用

Resumen de: CN120571071A

本发明公开了一种基于载细胞近场直写打印的三层神经导管及其制备方法和应用，特点是三层神经导管的内层为载细胞ALG/GelMA/PEO水凝胶支架，中层为PVA/GelMA静电纺丝膜，外层为熔融近场直写PCL支架，其制备方法包括将纺丝液通过静电纺丝制备为有序纤维膜PVA/GelMA，将有序纤维膜PVA/GelMA加入丙酮/戊二醛溶液得到PVA/GelMA静电纺丝膜的步骤，通过熔融近场直写在静电纺丝膜的任一单面打印直写PCL支架的步骤，将含细胞生物墨水通过载细胞近场直写打印制备为有序载细胞水凝胶支架的步骤，最后制备成三层神经导管，优点是能够加速轴突生长、促进髓鞘再生和改善神经功能恢复。

一种梯度异质结构锌合金植入物及其激光增材制备方法

Resumen de: CN120572021A

本发明公开了一种梯度异质结构锌合金植入物及其激光增材制备方法，首先构建梯度异质结构的三维模型，并经分层切片处理后导入选区激光熔化系统。以切片层为调控单元，在优化的激光能量密度范围内进行动态参数切换：高激光能量密度通过提升熔池热力学条件促进粗大晶粒生长，而低激光能量密度则通过急速冷却实现细小晶粒调控，最终形成具有周期性粗细晶层交替的梯度异质结构。结果显示梯度异质结构锌合金植入物展现出强度与延性的协同提升，其强化机制主要源于非均匀变形引起的应力、层间位错以及粗细晶粒交替层抑制应变局部化的综合作用。此外，该植入物还展现出优异的梯度抗菌作用。这为高性能锌合金植入物的设计和开发提供了可行的策略。

一种基于金字塔结构的鼻整形支撑系统

Resumen de: CN120570728A

本发明涉及医疗美容器械技术领域，且公开了一种基于金字塔结构的鼻整形支撑系统，包括金字塔基元模块、三维桁架系统、梯度孔隙基座、性能参数单元、3D打印参数设置模块、智能适配组件和智能监测模块，金字塔基元模块包括微金字塔结构单元，通过集成了金字塔基元模块、三维桁架系统、梯度孔隙基座、性能参数单元、3D打印参数设置模块、智能适配组件和智能监测模块，形成了一个高度集成化、智能化的鼻整形支撑解决方案，不仅提高了鼻整形手术的精准度和个性化程度，还大大增强了手术的安全性和效果，提高了结构稳定性，避免了在受剪切力时易偏转和单点支撑导致鼻尖皮肤具有穿透风险的情况发生，提高了血管化速率。

一种唇颊侧及腭侧双固位骨膜下种植体支架及制作方法

Resumen de: CN120570701A

本发明公开了一种唇颊侧及腭侧双固位骨膜下种植体支架及制作方法，种植体支架包括双固位支架主体，双固位支架主体上一侧设有固定于唇颊侧的螺钉孔，双固位支架主体上另一侧设有固定于腭侧的螺钉孔，双固位支架主体的中部设有多个种植基台；双固位支架主体通过扫描数据重建患者完整颌骨结构，提取唇颊侧与腭侧骨面轮廓，得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇侧与腭侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明在保证刚度和耐用性的同时，整体结构更加轻便，使用的螺钉数量更少，从而减轻患者佩戴时的压力，显著提高支架的使用寿命，减少压力性损伤的风险。

伤口敷料及其制备方法

Resumen de: CN120572672A

本发明涉及伤口敷料及其制备方法，包括以下步骤：S1、获取伤口三维尺寸，得到伤口模型；S2、根据伤口模型设计阳模，所述阳模包括基板和设置在基板一侧的多个微针模型，所述微针模型位于伤口模型内，且所有微针模型的尖端均处于伤口三维模型的伤口面上；S3、制备步骤S2设计的阳模；S4、利用阳模倒模制备PDMS微孔模具；S5、将负载药物的水凝胶前驱体溶液注入PDMS微孔模具，得到伤口敷料。本发明的伤口敷料，各个微针的长度与伤口的深度相匹配，使得各个微针的尖端能够有效接触到伤口面，从而有效传递药物，保证伤口的恢复效果。

一种用于治疗肝衰竭的原位生物3D打印人工肝脏贴片的构建方法

Resumen de: CN120571067A

本发明属于生物医学领域，具体涉及一种用于治疗肝衰竭的原位生物3D打印人工肝脏贴片的构建方法。本发明人工肝脏贴片主要成分是复合水凝胶，包括透明质酸(HA)、明胶(Gelatin)、海藻酸钠(sodium alginate)、甲基丙烯酰化明胶(GelMA)。复合水凝胶具有良好的3D打印性能，通过生物3D打印可实现人工肝脏贴片的规模化构建，为可移植的生物人工肝组织提供了一个潜在的解决方案。本发明所述人工肝脏贴片采用挤出式打印模式，成型速度快，并且内部的肝脏细胞仍能保持较高活性，可保证肝脏基础功能(糖原储存、药物代谢和分泌蛋白的合成等)的重建，在治疗肝功能衰竭疾病中具有重要潜力。

一种个性化治疗冠心病的血管支架及其制备方法

Resumen de: CN120570719A

本发明公开了一种个性化治疗冠心病的血管支架及其制备方法，所述制备方法包括如下步骤：S1、根据患者的基本信息、临床表现症状和CT扫描数据，对患者的冠状动脉情况进行分析评估，判断应采用的治疗方式；S2、结合患者的冠状动脉情况，针对患者情况设计出尺寸合适的血管支架，建立不同降解状态下的血管支架模型，对血管支架进行径向支撑性能有限元模拟测试和血流动力学模拟测试，确定适合病人个性化治疗的血管支架数据；S3、根据确定的血管支架数据，选择血管支架材料，根据血管支架尺寸和所选血管支架材料来制备血管支架。本发明能有效地实现冠心病患者的个性化治疗，提高血管支架介入治疗的效果，减少患者的经济成本。

Method for manufacturing a hip joint endoprosthesis

Resumen de: PL447880A1

Przedmiotem zgłoszenia jest sposób wytwarzania endoprotezy stawu biodrowego oraz sposób wytworzenia endoprotezy stawu biodrowego z wypełnieniem strukturalnym, o obniżonej masie i dedykowanej wytrzymałości oraz kształcie do potrzeb. Sposób wytwarzania przedstawionej na rysunku endoprotezy stawu biodrowego charakteryzuje się tym, że obejmuje następujące etapy: przeprowadza się CT i/lub przeprowadza się MRI stawu biodrowego, opracowuje się model numeryczny kości na podstawie badań CT lub badań MRI, przeprowadza się analizę numeryczną i wyznacza się stan naprężeń stawu biodrowego podczas obciążenia wynikającej z motoryki, opracowuje się model geometryczny endoprotezy stawu biodrowego; opracowuje się graniczne parametry wytrzymałościowe endoprotezy stawu biodrowego i dobiera się zagęszczenie wypełnienia strukturalnego endoprotezy stawu biodrowego; analizuje się stan naprężeń stawu biodrowego po endoprotezoplastyce podczas obciążeń wynikającej z motoryki; eksportuje się dane numeryczne z kształtem oraz geometrę wewnętrzną endoprotezy stawu biodrowego, wykonuje się model z wykorzystaniem technik addytywnych, zgęszcza się materiał z wykorzystaniem metod obróbki cieplno-ciśnieniowej w atmosferze gazu obojętnego, zasklepia się otwory technologiczne; obrabia się wykańczająco; sterylizuje się i pakuje się.

ARRANGEMENT AND METHOD FOR MANUFACTURING A PLURALITY OF ORTHODONTIC APPLIANCES

Resumen de: US2024391170A1

The invention relates to an arrangement for manufacturing a plurality of orthodontic appliances in parallel, including an additive printing machine comprising a build platform and configured for additively manufacturing a plurality of teeth models in parallel, a plurality of plates each configured for teeth model printing by the additive printing machine, whereby each plate comprises a unique machine-readable identifier and each plate is detachable and precisely fixed to the build platform, and a thermoforming machine configured for thermoforming a thermoformable material over the plurality of teeth models for receiving the plurality of orthodontic appliances.

牙齿修复体制造的FEM分析

Resumen de: US2025268690A1

A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.

一种组织工程基质及其用途

Resumen de: CN120550195A

本申请提供了一种组织工程基质，其包括功能单元、微凝胶、光交联分子和生物活性分子，所述组织工程基质经紫外光光照后能够形成具有高细胞密度的可血管吻合植入的组织或器官。本申请中的组织工程基质由高密度功能单元、微凝胶、光交联分子和生物活性分子复合形成，可以同时满足生物打印要求的力学性能和生物活性，根据功能单元的类型可作为嵌入式打印墨水或挤出式打印墨水，构建形成的组织器官可用于药物开发与筛选、制备病理研究模型或者植入功能补偿病损的组织器官。

一种基于3D打印的苯巴比妥口崩微片及其制备方法

Resumen de: CN120549876A

本发明公开了一种基于3D打印的苯巴比妥口崩微片，主要由以下质量百分比的组分采用3D打印技术制备而成：苯巴比妥15％～70％，填充剂10％～60％，崩解剂0％～50％，矫味剂0.1％～2％，粘合剂0％～15％。本发明还公开了该苯巴比妥口崩微片的制备方法。所述的苯巴比妥口崩微片药物释放速度快，可提高患者服用药物的依从性，尤其方便婴幼儿等吞咽困难者服用。

微凝胶生物墨水、包含神经-血管网络的微凝胶支架及其制法和应用

Resumen de: CN120550196A

本发明提供了微凝胶生物墨水、包含神经‑血管网络的微凝胶支架及其制法和应用，属于生物医药技术领域。本发明制备得到的微凝胶生物墨水打印时具备显著自愈合能力，确保高精度挤出成型，剪切稀释能力优异，黏度随剪切速率增加显著降低；在生理温度下保持固态结构，具备温敏稳定性；自愈合效果显著，提升打印体机械稳定性，具有良好的打印挤出和成形能力。本发明实现了载神经元与血管内皮细胞微球的复合打印，成功构建了包含神经‑血管网络的微凝胶支架，能够用于模拟体内微环境互作机制，为复杂组织缺损修复提供一体化解决方案。

基于纤维蛋白原的重组蛋白

Resumen de: US2024294607A1

The present invention relates to isolated, recombinant polypeptides comprising the gamma chain of fibrinogen and a His-Tag. The present invention further relates to nucleic acids encoding said polypeptides, vectors comprising said nucleic acids, host cells, preferably bacterial host cells, comprising said nucleic acids or vectors, biohybrid materials comprising conjugates comprising said polypeptides, uses of the above, and methods for producing said polypeptides.

兼柱状晶向等轴晶转变和强塑性的钛氧铜合金及制备方法

Resumen de: CN120555818A

本发明涉及一种兼柱状晶向等轴晶转变和强塑性的钛氧铜合金及制备方法，该钛氧铜合金为Ti‑xCu‑yO，其中Cu占钛氧铜合金的重量百分含量比值为2.6≤x≤3.2，O占钛氧铜合金的重量百分含量比值为0.3

一种基于4D打印的多孔Niti合金仿生骨梯度结构构建方法

Resumen de: CN120551422A

本发明涉及医用植入物技术领域，具体是一种基于4D打印的多孔Niti合金仿生骨梯度结构构建方法，包括患者骨数据采集、仿生梯度模型设计、NiTi粉末制备、4D打印、热处理激活记忆效应、表面功能化处理、力学/生物性能测试，其特征在于：包括以下制备步骤：本发明，通过CT/MRI精准获取骨结构数据，结合Mimics预处理与UG/NX建模，针对皮质骨（低孔隙率30%‑40%）和松质骨（高孔隙率50%‑70%）差异化设计孔径与孔隙率，经ANSYS模拟典型载荷工况，使弹性模量（3‑15GPa）、抗压强度（80‑200MPa）接近天然骨，该设计显著降低植入体与宿主骨的弹性模量差，避免应力屏蔽导致的骨吸收问题，同时通过功率渐变技术实现孔隙率连续过渡，提升复杂载荷下的结构稳定性。

CONTINUOUS FIBER SUPPORT BARRIER FOR ENGINEERED VASCULAR NETWORKS

Resumen de: US2025269094A1

Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.

Tissue-Augmented Corneal Inlay Surgery Technique

Resumen de: US2025268756A1

A tissue-augmented corneal inlay surgery technique is disclosed herein. In one embodiment, the surgery method includes the steps of: (i) implanting a corneal inlay into a recipient cornea of an eye of a patient; (ii) applying laser energy to a central portion of the corneal inlay and a portion of stromal tissue of the recipient cornea underneath the corneal inlay so as to modify the refractive power of the eye; (iii) applying a cross-linking solution that includes a photosensitizer to the recipient cornea of the eye of the patient; and (iv) irradiating the corneal inlay and surrounding corneal tissue so as to activate cross-linkers in the corneal inlay and the surrounding corneal tissue. In this embodiment, the central portion of the corneal inlay remains clear for the patient without being obstructed by swollen tissue so that the patient is able to see immediately after the corneal inlay surgery.

Apparatus and Methods for Small Joint and Bony Defect Replacement

Resumen de: US2025268718A1

Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.

SYSTEMS AND METHODS FOR INKING A CATHETER BALLOON

Resumen de: US2025269402A1

Systems and methods are provided for applying visualization features to one or more expandable members. In some embodiments, a modular rack system is provided that is configured to receive one or more expandable members. The modular rack system comprises one or more elongate rods assemblies, with each rod assembly being sized and shaped to receive a single expandable member. An inking system is configured to apply one or more visualization features on the one or more expandable members. The one or more visualization features are applied to each of the one or more expandable members such that each of the one or more expandable members has identical visualization features thereon.

FEM ANALYSIS FOR THE PRODUCTION OF DENTAL RESTORATIONS

Resumen de: US2025268690A1

A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.

SYSTEMS AND METHODS FOR RAPID LIQUID BIOPRINTING

Resumen de: US2025270502A1

Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.

STRETCHABLE SELF-HEALING HYDROGEL

Resumen de: US2025270389A1

The present invention relates to a stretchable self-healing hydrogel. The hydrogel has excellent mechanical properties and stability, and stretchable and self-healing properties, and can be useful as a hydrogel for delivery of a drug or a cell, and a composition for 3D bioprinters.

COLLAGEN BIOMATERIAL DERIVED FROM ABALONE

Nº publicación: US2025270291A1 28/08/2025

Solicitante:

BIO CONSULTANCY PTY LTD [AU]
Bio Consultancy Pty Ltd

Resumen de: US2025270291A1

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.