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一种医用纤维增强复合材料的制备方法

Resumen de: CN121668390A

本发明提供了一种医用纤维增强复合材料的制备方法，属于医用材料技术领域。本发明提供一种兼具高屈服强度和弹性模量，且孔隙率大的医用纤维增强复合线材的制备方法，进一步可通过3D打印得到医用材料，提高力学性能的同时，提高材料的孔隙率，孔道结构也有利于营养液输送，显著提高支架结构的生物活性，且制备方法简便，满足多种医疗器械应用需求。

A method of manufacturing a custom-made earpieces using a prediction of a future auditory duct geometry and a corresponding custom-made earpieces.

Resumen de: NL2038517B1

A B S T R A C T A method of manufacturing a custom-made, said method comprising the steps of: providing, for each of a plurality of persons, at least two scans of auditory ducts, wherein said provided at least two scans of said auditory ducts, for each person of said plurality of persons, relate to scanned auditory ducts of said corresponding person separated in time; determining, using a scan of an auditory duct of a person, a predicted geometry of said auditory duct of said person based on a prediction model, wherein said predicted geometry of said auditory duct of said person is separated in time from said scan of said auditory duct of said person, said prediction model being based on a drift identified in geometry of said provided scanned auditory ducts in two scans separated in time for each of said persons of said plurality of persons; manufacturing said custom-made earpiece for said person based on said predicted geometry of said auditory duct of said person.

壳状牙科器械制作方法

Resumen de: WO2021147336A1

A method for fabricating a shell-shaped dental instrument, comprising: obtaining a three-dimensional digital model of a shell-shaped dental instrument (101); inspecting the three-dimensional digital model of the shell-shaped dental instrument (103); according to the result of inspection, directly modifying the three-dimensional digital model of the shell-shaped dental instrument (105); and using 3D printing technology to make the shell-shaped dental instrument on the basis of the modified three-dimensional digital model of the shell-shaped dental instrument (107). The present method can overcome the limitations on various aspects of a shell-shaped dental instrument caused by the limitedness of the traditional hot pressing film forming process.

一种用于深部脑神经定向再生的微型蠕动器及其制备方法

Resumen de: CN121647847A

本发明涉及蠕动器技术领域，且公开了一种用于深部脑神经定向再生的微型蠕动器，包括微型蠕动器，所述微型蠕动器的表面设置有褶皱结构，所述微型蠕动器的内部设置有驱动结构，所述驱动结构为记忆合金丝，通过电流控制记忆合金丝，实现收缩与断电恢复形变，进而驱动微型蠕动器产生蠕动运动。本发明中，微型蠕动器整体呈蠕虫状且由两个C形结构组成，配合表面连续环状褶皱结构，可模拟自然界生物在狭窄空间的高效蠕动模式，既能适配深部脑神经区域复杂的管腔与组织间隙，又能避免蠕动过程中对周围软组织的刮擦损伤，同时褶皱结构为运动提供稳定波形动力，确保在精细神经环境中灵活前行。

用于通过3D喷墨打印制备由氧化锆制成的陶瓷成形体的方法和料浆

Resumen de: US2025018599A1

Process and slip for the production of ceramic shaped parts made of zirconium oxide ceramic by a 3D inkjet printing process. The slip contains zirconium oxide which is suspended in a liquid medium, wherein the slip has a zirconium oxide content of from 68 to 88 wt.-% and contains not more than 5 wt.-% organic components. The process for the production of ceramic components comprises the layered shaping and subsequent sintering of the desired component from the slip.

3D SYSTEM AND METHOD FOR PRODUCING PHARMACUTICAL OBJECTS VIA 3D PRINTING

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)

用于经由3D打印生产药物对象的系统和方法

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)

儿童咬合垫、基于适应性咬合的儿童咬合矫治系统及其设计方法

Resumen de: CN121647835A

本发明公开了儿童咬合垫、基于适应性咬合的儿童咬合矫治系统及其设计方法，儿童咬合垫包括两个本体，两个本体被配置为覆盖佩戴者上颌/下颌左侧后牙区和右侧后牙区，两个本体之间通过连接部连接；本体包括朝向对颌牙列的咬合面、以及朝向其所覆盖牙列的组织面；组织面形成有用于容纳目标牙齿的萌出窝；萌出窝由侧壁和与目标牙齿咬合面相适配的窝底壁限定而成，侧壁围绕一引导轴线延伸；其中，本体被配置为在佩戴状态下，引导轴线相对于佩戴者的腭平面垂线具有预设偏转角度，以通过引导轴线的方向引导目标牙齿的萌出；萌出窝的窝底壁具有沿引导轴线方向测量的预设厚度。本发明提供的儿童咬合矫治系统既能提高固位力，又能根据错��类型主动引导牙齿定向萌出、重塑功能咬合平面，从而通过消除下颌内旋/外旋机制来矫治颌骨畸形。

一种3D打印掺镁矿化胶原复合骨支架及其制备方法

Resumen de: CN121648350A

本发明化学技术领域，具体涉及一种3D打印掺镁矿化胶原复合骨支架及其制备方法，复合骨支架主要由掺镁矿化胶原、羟基磷灰石和左旋聚乳酸制成，左旋聚乳酸、镁矿化胶原和羟基磷灰石质量比为3~5∶2~4∶1。制备方法，其步骤为：胶原蛋白溶解在酸性缓冲溶液中，滴加含PO43‑溶液后，再依次滴加含Ca2+与Mg2+的混合盐溶液，制得混合溶液；S13在混合溶液中加入碱溶液调节混合溶液pH至8.0~9.0，生成掺镁矿化胶原；将掺镁矿化胶原、左旋聚乳酸和羟基磷灰石混合后通过3D打印制成复合骨支架。本发明的制备方法，克服胶原不稳定的技术偏见，可以实现一步共沉淀法钙镁磷共沉积。

ADDITIVE MANUFACTURING OF VINYL PHOTOCROSSLINKABLE POLYMERS

Resumen de: US2022257827A1

Various precursor solutions and methods of 3D printing and other additive manufacturing approaches are provided for the manufacture of articles using photocrosslinkable vinyl shape memory polymers. In various aspects, articles are manufactured by a process comprising (i) exposing a precursor solution to an intensity and frequency of light to initiate photo-polymerization of the precursor solution to form a layer of the article; and (ii) repeating step (i) a number of times to form the article in a layer-by-layer approach; wherein the precursor solution comprises a first polymeric precursor comprising a plurality of vinyl terminated side-chains attached thereto. A vinyl-functionalized, photocrosslinkable SMP used as an example herein is a novel variant of a previously disclosed SMP composition, with higher amounts of vinyl functionalization but similar thermomechanical properties to the SMP library previously disclosed. Moreover, a unique combination of chemistries is disclosed that incorporates the aforementioned vinyl-functionalized SMPs along with acrylate-based crosslinkers. Additional novel compositions are disclosed containing the vinyl-functionalized SMPs with additional dithiol functionalizations, vinyl-functionalized SMPs with dithiol crosslinkers, as well as vinyl-functionalized SMPs with both acrylate-based and dithiol crosslinkers, as another means to tune degradation rates and other material properties. The articles can include a variety of articles such as stents

一种功能化骨软骨修复材料及其制备方法

Resumen de: CN121648349A

本发明公开了一种功能化骨软骨修复材料，包括依次连接的软骨层、过渡层和骨层，所述软骨层以透明质酸、I型胶原蛋白和壳聚糖为基材，所述过渡层以羟基磷灰石和聚乳酸‑羟基乙酸共聚物为基材，所述骨层以β‑磷酸三钙、羟基磷灰石和聚乳酸‑羟基乙酸共聚物为基材，本发明涉及医用生物材料技术领域，通过设计有机‑无机复合过渡层，梯度衔接软骨层和骨层，界面剪切强度≥0.5MPa，有效解决了传统分层材料层间剥离的问题，能承受关节运动时的剪切应力和压缩应力，制备工艺采用冷冻干燥、模压成型、烧结等成熟医用材料生产设备，可实现规模化批量生产，同时支持选择性激光烧结3D打印的个性化制备，适配不同临床场景需求。

SYSTEM AND METHOD FOR PRODUCING PHARMACEUTICAL OBJECTS VIA 3D PRINTING

Resumen de: US20260069503A1

Method for 3D printing, comprising the following steps: providing a packaging (2′) having at least one recess (3′) for receiving a product (1′), wherein the shape of the recess (3′) corresponds at least in part to the shape of the product (1′) and wherein the recess (3′) forms a protuberance at the other side of the packaging (2′); providing a 3D printer with a print base (5′) having at least one recess (6′) for receiving the protuberance formed by the recess (3′) of the packaging (2′); inserting the packaging (2′) in the print base (5′) such that the protuberance formed by the recess (3′) of the packaging (2′) is received by the recess (6′) of the print base (5′); filling a print head (7′) of the 3D printer with at least one material for printing the product (1′); 3D printing the product (1′) inside the recess (3′) of the packaging (2′), wherein the part of the recess (3′) corresponding to the shape of the product (1′) serves as the mold and print support, resp., for those layers of the product (1′) which are 3D printed first. The method is performed with a system for 3D printing, comprising a packaging (2′) having at least one recess (3′) for receiving a product (1′), wherein the shape of the recess (3′) corresponds at least in part to the shape of the product (1′) and wherein the recess (3′) forms a protuberance at the other side of the packaging (2′); and a 3D printer with a print head (7′) and a print base

SUCTION TOOTHBRUSH AND RELATED METHODS

Resumen de: US20260069028A1

A suction toothbrush includes a handle defining an opening, a toothbrush head including internal channels, a seal with a distal end received within the toothbrush head and a proximal end coupled to the handle through the opening thereof, and a connector extending through the annular body of the seal. The connector includes a main body having a distal end disposed within the internal conduit of the toothbrush head and a proximal end extending into the handle through the top opening thereof, and a vibration motor housing offset from the proximal end of the main body. A waste reservoir for a suction toothbrush includes a lid, a basin defining a sump for waste material, and a gas-permeable membrane disposed between the lid and the basin that defines central inlet opening. A 3-D printing method for suction toothbrush heads.

DENTAL APPLIANCES WITH INTERPROXIMAL ENGAGEMENT STRUCTURES

Resumen de: US20260069385A1

Dental appliances and associated systems are provided. In some embodiments, a dental appliance includes a shell configured to receive a plurality of teeth, the shell having a sidewall and an interproximal engagement structure extending from the sidewall into a space of an interproximal region between a first tooth and a second tooth of the plurality of teeth. The interproximal engagement structure can be configured to contact the first tooth and the second tooth concurrently. The interproximal engagement structure can be larger than the space of the interproximal region, such that the contact causes deformation of one or more of the interproximal engagement structure or the sidewall.

MULTI-MODAL PATIENT-SPECIFIC SURGICAL GUIDES

Resumen de: US20260069290A1

A surgical device includes a first body component including at least one insert embedded therein and a second body component including a patient-specific surface. The first body component includes a first material and the at least one insert includes a second material. The first body component defines at least one first hole and the second body component defines at least one second hole. The second body component is configured to be coupled to the first body component such that the at least one first hole and the at least one second hole are aligned when the first body component is coupled to the second body component to define at least one continuous fixation hole sized and configured to receive an elongate fixation device at a predetermined location.

MEDICAL DEVICES AND RELATED METHODS

Resumen de: US20260069260A1

A medical device includes an operating member, a hub, and an end effector. The operating member includes an actuation portion. The hub includes a channel receiving the actuation portion of the operating member. The actuation portion of the operating member moves within the channel. The end effector is movable between a closed configuration and an open configuration. Distal extension of the operating member transitions the end effector to the open configuration, and proximal retraction of the operating member transitions the end effector to the closed configuration. The medical device is formed through an additive manufacturing process.

AUGMENTED REALITY SCANNING INTERFACE FOR GENERATING PERSONALIZED 3D PRINTED CASTS

Resumen de: US20260069145A1

A method of generating a 3D model of a body part includes scanning the body part with a 3D scanner; during the scanning step, generating, with an augmented reality user interface, an augmented reality view of said body part, wherein the augmented reality view differentiates between portions of the body part that have already been scanned and portions that have not yet been scanned; with guidance from the augmented reality view, completing the scan; and generating the 3D model based on data received from the scan. The augmented reality view is displayed on a practitioner-facing screen incorporated into the scanning device. The method may further include imaging the body part with a thermal imager and overlaying thermal scanning data onto the 3D model to thereby generate a distribution map of thermal sensitivity on the 3D model. The design is then generated with holes situated to maximize thermal comfort.

MOLECULARLY CLEAVABLE BIOINK FORMULATION

Resumen de: US20260071187A1

A bioink formulation for digital light processing bioprinting comprising a mixture of a biocompatible cleavable polymer precursor, a biocompatible non-cleavable polymer precursor, and a photoinitiator is described. Three-dimensional (3D) objects prepared using these bioink formulations are also described. In addition, a method of 3D bioprinting is described. The method includes providing a bioink formulation in a 3D bioprinter vat; repeatedly photoactivating the biocompatible photoactive polymer precursors in the 3D bioprinter vat on a build plate immersed in the vat to form a 3D bioprinted object comprising polymers having a series of predefined shapes across the vertical direction based on a set of sliced images; and treating the 3D bioprinted object with an agent that cleaves chemical bonds within the cleavable polymer.

ARTICLES INCLUDING A MICROSTRUCTURED CURVED SURFACE, TOOLING ARTICLES, AND METHODS

Resumen de: US20260070777A1

The present disclosure provides a microstructured article including a thermoplastic polymer shaped to have a curve. At least a portion of the curve includes a microstructured surface of utilitarian discontinuities and the microstructured surface includes peak structures and adjacent valleys. The peak structures and the curve are formed of a single piece of the thermoplastic polymer. A method of making the microstructured articles is also provided including a) obtaining a tool shaped to include at least one of a protrusion or a concavity; b) disposing a microstructured film on at least a portion of the tool including the protrusion and/or the concavity; and c) thermoforming a single piece of thermoplastic polymer onto the tool to form a microstructured article shaped to include a curve. The curve is an inverse of the protrusion or the concavity of the tool.

PATIENT INTERFACE

Resumen de: AU2026201217A1

A patient interface comprises a support structure and a seal-forming structure. The support structure is arranged to support the sealing portion and is configured to connect to the frame. The sealing portion comprises textile and is attached to the support structure along an outer perimeter of the sealing portion such that in use the sealing portion may be in tension due to reactive stress of the support structure and/or a resilient stretch characteristic of the textile such that the sealing portion exerts a force against the patient’s face. eb e b

Tibia-Implantat

Resumen de: DE102024126035A1

Die Erfindung betrifft ein Tibia-Implantat (2) für Gelenkersatz, welches aus Metalllegierung in einem additiven Fertigungsverfahrenhergestellt ist, mit einem Plateauabschnitt (4) und mit einem auf der tibiazugewandten Seite (8) des Plateauabschnitts (4) vorspringenden und sich davon in einer axialen Richtung (10) wegerstreckenden zapfen- oder kielförmigen Ankerabschnitt (6),; erfindungsgemäß wird vorgeschlagen, dass der Plateauabschnitt (4) auf seiner tibiazugewandten und mit Tibiaknochengewebe in Kontakt gelangenden Seite (8) eine dreidimensional poröse offenporige Oberflächenstruktur (14) mit in der axialen Richtung (10) hintergreifbaren Brücken, Stegen oder Wandbereichen aufweist, wobei die offenporige Oberflächenstruktur (14) eine erste Rauigkeit aufweist, und dass der Ankerabschnitt (6) anschließend an den Plateauabschnitt (4) in einem ersten axialen Ankerbereich (20) umfangsseitig eine in einer radialen Richtung (12) hinterschnittfreie, das heißt von hintergreifbaren Brücken und brückenbildenden Stegen freie Oberflächenstruktur (28) mit einer zweiten Rauigkeit aufweist, die geringer ist als die erste Rauigkeit, und dass der Ankerabschnitt (6) in der axialen Richtung (10) anschließend an den ersten axialen Ankerbereich (20) einen zweiten axial frei endenden axialen Ankerbereich (22) mit einer glatten Oberfläche aufweist.

STERNAL IMPLANT

Resumen de: WO2026055711A1

A sternal implant for implant into a body is provided. The implant includes an outer frame forming a structurally rigid portion. The outer frame includes a plurality of openings configured to accommodate sutures for affixing the outer frame to the body. The implant includes a central structure connected within the outer frame. The central structure includes a in the form of a layer having a construction including multiple channels. The filling portion is configured to allow for fluid drainage and tissue ingrowth of tissue generated by the body.

ANCHOR FOR USE WITH ORTHODONTIC APPLIANCE

Resumen de: WO2026053080A1

An anchor for use with an orthodontic appliance is provided. The anchor is configured to be coupled to an anchor surface defining a reference plane. The anchor includes a base configured to be coupled to the anchor surface, such that the reference plane interfaces with the base. The anchor further includes a hook portion extending from the base and curving towards the reference plane. The hook portion includes a tip distal to the base. The hook portion defines a pocket having a minimum width relative to the reference plane. A maximum distance between the tip and the reference plane is less than the minimum width of the pocket.

MEMBRANE, MEMBRANE CONTACTOR, AND METHOD FOR PRODUCING A MEMBRANE

Resumen de: WO2026052280A1

The invention relates to a membrane (1) for a membrane contactor (2), which membrane is in the form of a hollow three-dimensional tube structure located on both sides of a plane/central plane (ME), in particular a hollow tube structure which is mirror-symmetrical to the plane/central plane and consists of branched tubes (3, 3 ́, 3 ́ ́, 3 ́ ́ ́, 3 ́ ́ ́ ́), preferably not exclusively planar branched tubes (3, 3 ́, 3 ́ ́, 3 ́ ́ ́, 3 ́ ́ ́ ́) having a plurality of branching planes (VE) in parallel with the plane/central plane (ME) on both sides of the plane/central plane (ME), wherein the walls of the tube structure are permeable to substances and/or permeable to energy, and wherein, in the region (B) of each branching plane (VE), each tube (3, 3 ́, 3 ́ ́, 3 ́ ́ ́) extending towards the plane/central plane (ME) branches into a plurality of tubes (3 ́, 3 ́ ́, 3 ́ ́ ́, 3 ́ ́ ́ ́) extending with respect to the plane/central plane (ME), and the tubes (3 ́ ́ ́ ́) extending from both sides of the plane/central plane (ME) from the corresponding last branching plane (VE) with respect to the plane/central plane (ME) merge into one another in the region (ÜB) of the plane/central plane (ME). The invention also relates to a membrane contactor (2) having a membrane of this type, and to a method for producing a hollow membrane (1).

SYSTEMS AND METHODS FOR STITCHING FRAMES IN A VIDEO CAPTURED IN BIOPRINTING

Nº publicación: WO2026053003A2 12/03/2026

Solicitante:

ASPECT BIOSYSTEMS LTD [CA]
ASPECT BIOSYSTEMS LTD

Resumen de: WO2026053003A2

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a material flow while passing through and/or exiting from the bioprinting system, wherein the passage of the plurality of cells through the bioprinting system creates a printed fiberduring and/or after. A computing system may identify a first frame in the imaging data captured at time t-n and a second frame in the imaging data captured at time t, generating, via a machine learning algorithm executing on the imaging data, a plurality of segmented regions in the imaging data, wherein each segmented region in the plurality of segmented region defines a boundary around a different set of cell aggregates or cells in the plurality of cells, determining, for combining with the first frame and based on the plurality of segmented regions, a portion of the second frame that is substantially non-overlapping with the first frame, determining, based on the plurality of segmented regions, one or more cells or cell aggregates in the plurality of cells that are located along an edge of the first frame or an edge of the portion of the second frame, identifying a seam where the first frame and the portion of the second frame are to be combined based at least on locations of the one or more cells or cell aggregates, combining the first frame and the portion of the sec