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PROCESS FOR THE MANUFACTURE OF A SOLID PHARMACEUTICAL ADMINISTRATION FORM

Resumen de: WO2024038000A1

The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process that allows the production of a solid pharmaceutical solid administration form comprising an amorphous solid dispersion in an easy and flexible manner and the possibility to achieve fast disintegrating dosage forms with high drug loads.

Moulded infant product

Resumen de: GB2636639A

A moulded article 104 comprises a surface, particularly a child-safe product suitable for babies or infants, the article comprises first 110 and second 120 volumes of material compression moulded together to form a moulded surface, the first volume having a first colour and the second volume having a second colour different from the first, and wherein the moulded surface includes a third volume of material co-moulded with the first and second materials. The first volume of material is selectively deposited in the mould by drip moulding or by a three-dimensional printing process, wherein the first and second areas of different colours define a predetermined image, text or symbol on the moulded surface of the article. The first component may have an internal surface, pre-formed with one or more undulations (142, fig. 3) into which the material of the second component is pressed to form a co-extensive internal bonded surface therebetween. The materials may be food-grade silicone, preferably containing antimicrobial silver powder and/or another biocide. A method of moulding an article is also provided.

VINYL ETHER-BASED INKJET INK PHOTOPOLYMERIZED BY THIOL-ENE CLICK CHEMISTRY USED FOR TOUGHENING OF PHOTOPOLYMERS

Resumen de: US2024059927A1

The present disclosure provides a range of printed materials comprising discrete layers or segment with distinct compositions, and which can collectively lend to high levels of strength, toughness, and break resistance, and these printed materials may contain thin, ductile layers interspersed between thicker, harder layers, thus in printing such materials, the present disclosure further provides a range of compositions and methods, including low viscosity, air stable, and rapidly solutions amenable to thin layer inkjet printing.

METHODS FOR PRODUCING ADDITIVELY MANUFACTURED OBJECTS WITH HETEROGENEOUS PROPERTIES

Resumen de: US2024051246A1

Methods for manufacturing objects are provided herein. In some embodiments, a method includes receiving a dental appliance formed using an additive manufacturing process, the dental appliance including a plurality of appliance portions. The method can include identifying, based on sensor data, a location of a subset of the appliance portions on the dental appliance. The method can further include applying energy to a subset of the appliance portions to selectively modify one or more material properties of the subset of the appliance portions.

PROGRAM FOR DESIGNING CLEAR ORTHODONTIC APPLIANCE BY USING COMPUTER

Resumen de: EP4574086A1

The present invention is characterized by the following steps:Generating and storing multiple dental images sequentially configured according to each correction stage (S01), Displaying any one of the multiple dental images from the previous step (S02), After displaying the dental image in step S02, setting and displaying a reference line in the transverse direction for each tooth to determine the overall shape of the transparent orthodontic aligner (S03), Setting a cutting line corresponding to the end portion of the orthodontic aligner, which is spaced a certain distance from the gum direction based on the reference line, and displaying it on the dental image from step S02 (S04), Displaying the first treatment image, which shows the transparent orthodontic aligner partially covering both the upper and lower dental arches, based on the cutting line set in step S04(S05).

An artificial endometrium containing cell-laden tubules and manufacturing method thereof

Resumen de: KR20250092409A

본 발명은 DLP 방식의 바이오 3D 프린터를 사용하여 세포가 함유된 도관이 매립된 인공 자궁내막 구조체 및 이의 제조 방법에 관한 것으로, 본 발명에 따른 인공 자궁내막 구조체는, 광가교성 하이드로겔 전구체에 자궁내막 기질세포, 자궁내막 줄기세포, 혈관내피세포가 혼합된 서로 다른 바이오 잉크를 제조한 후, 다중재료 바이오 DLP 3D 프린팅을 통해 제조될 수 있으며, 자궁내막 줄기세포가 포함된 제1영역; 상기 제1영역과 직접 접하도록 연결되며, 자궁내막 기질세포가 포함된 제2영역; 및 상기 제1영역과 제2영역을 동시에 관통하고 내벽에 혈관내피세포가 포함된 중공관 형태의 제3영역;을 포함한다

一种纳米硅-石墨烯协同增强的锌基骨植入物及其制备方法

Resumen de: CN120189554A

本发明公开了一种纳米硅‑石墨烯协同增强的锌基骨植入物的制备方法，包括如下操作步骤：S1、制备稳定的氧化石墨烯悬浮液；S2、制备硅悬浮液；S3、制备氧化石墨烯‑纳米硅混合粉末再通过热还原反应得到石墨烯‑碳化硅‑纳米硅复合粉末；S4、制备锌/石墨烯‑碳化硅‑纳米硅混合粉末；S5、以锌/石墨烯‑碳化硅‑纳米硅混合粉末为原料，在保护气氛下，采用选择性激光熔化工艺制备得到锌基骨植入物；本发明还提供一种采用上述制备方法制得的锌基骨植入物。本发明可显著改善锌基骨植入物的力学性能，制备得到的锌基骨植入物具有较优异的生物活性。

Simple 3D Printing Batch Rats Fixator

Resumen de: LU509511B1

The invention discloses a simple 3D printing batch rats fixator, which comprises a fixation plate which is divided into a plurality of fixing areas; the fixing area includes: fixing columns, which are arranged at the four corners of the fixing area and are fixedly connected with the fixation plate; a head fixing ring, which is arranged between the top two fixing columns and fixedly connected to the top surface of the fixation plate; neck fixing holes, which are arranged in pairs and are symmetrical about the axis of the head fixing ring; trunk fixing holes, which are arranged in pairs and symmetrical with respect to the axis of the head fixing ring, are located at the side of the neck fixing hole far away from the head fixing ring; the neck fixing hole, the trunk fixing hole and the fixing columns are all provided with binding structures (Fig.1)

一种缺氧诱导血管化功能的3D打印人工骨及其制备方法与应用

Resumen de: CN120189550A

本发明属于骨修复材料技术领域，公开了一种缺氧诱导血管化功能的3D打印人工骨及其制备方法与应用，一种缺氧诱导血管化功能的3D打印人工骨，在人工骨表面设置二级孔隙结构，所述二级孔隙结构与人工骨孔隙连通并均匀分布在人工骨表面，所述二级孔隙结构为半封闭结构。本发明通过构建开口小内腔大的半封闭孔结构，在结构空间限制下，此人工骨的孔内部逐渐形成缺氧微环境，聚集的细胞产生缺氧诱导因子HIF‑1α，通过缺氧诱导信号通路诱导和促进血管生长。此3D打印人工骨无需添加药物，减少了加工成本和避免了药物副作用，通过内部半封闭结构设计实现缺氧诱导的机理加速血管化，促进骨组织再生，改善了3D打印人工骨的血管化成骨功能。

用于生物打印机的可拆卸打印头及生物打印机

Resumen de: WO2024098119A1

A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.

格子容積を組み込んだ外科用インプラントデバイスおよび関連する製造方法

Resumen de: AU2025202950A1

The present disclosure provides a surgical implant device, including: a solid surface; and a lattice structure disposed adjacent to the solid surface, wherein the lattice structure includes a first plurality of struts that define a first plurality of voids adjacent to the solid surface and a second plurality of struts that define a second plurality of voids remote from the solid surface. The surgical implant device may also include one or more screw hole regions and/or a needle-populated porous surface disposed adjacent to the solid surface opposite the lattice structure. Fig 1 10,16 12 14b 14c14

用于骨植入的骨采集装置

Resumen de: AU2023371661A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body, a scaffold within the body, and a means for focusing bone growth throughout the body. The device is designed to minimize shear stresses on a distal tip and distribute micromotion to encourage bony ingrowth. The scaffold may include a triply periodic minimal surface (TPMS) with a cubic repeating pattern defining walls within the scaffold, and the TPMS may be helically wrapped around a central axis of the device. The device may also house biologic agents and accommodate an autologous product. In some embodiments, the medical device is a bone screw or a pedicle screw, designed to reduce common issues such as screw loosening, screw backout, and rod breakage. The method of treatment involves implanting the medical device into a patient's bone to aid fracture healing.

用于对增材制造对象的表面进行改性的系统和方法

Resumen de: US2024091906A1

Systems and methods for processing additively manufactured objects are described herein. In some embodiments, for example, a system includes a controller configured to provide one or more control signals; a heater coupled to the controller, where the heater comprises one or more heating elements arranged to heat a blasting medium in response to the one or more control signals; a chamber coupled to the controller, where the chamber comprises an agitatable drum shaped to receive a plurality of additively manufactured objects, and to agitate the plurality of additively manufactured objects in response to the one or more control signals; and an applicator coupled to the controller, where the applicator comprises a nozzle operative to direct, in response to the one or more control signals, a plurality of thermally conductive particles in the blasting medium toward the plurality of additively manufactured objects within the agitatable drum.

液滴生成装置、インクジェット装置、及び薬液デリバリー装置

Resumen de: JP2025093255A

【課題】従来よりも高いエネルギー密度で液体から液滴を生成することができ、また、構成部品の損傷を防止することもできる液滴生成装置、インクジェット装置、及び薬液デリバリー装置を提供すること。【解決手段】液滴生成装置１００は、全反射面６Ａで入射レーザ光ＬＳＲ１を全反射させることにより全反射面６Ａから液体２に染み出すエバネッセント光ＥＶＬを、導電性ナノ粒子７に照射する。これにより、液滴生成装置１００は、エバネッセント光ＥＶＬによって導電性ナノ粒子７でプラズモン共鳴を励起させ、全反射面６Ａから離れた位置で電界強度を増強させることにより液体２にエネルギーを与え、液体２を液滴化させる。【選択図】図１

支具建模方法、设备、介质及支具制作方法

Resumen de: WO2024045916A1

The present application relates to the technical field of brace design, and relates to a brace modeling method, a device, a medium, and a brace manufacturing method. The brace modeling method comprises: obtaining a three-dimensional model of a target part of a limb; determining feature mark points of the three-dimensional model; determining brace modeling parameters of the three-dimensional model according to the feature mark points; and on the basis of the brace modeling parameters, generating brace file information corresponding to the target part, so that a brace can be manufactured later by using the brace file information. Thus, the convenience and accuracy of brace modeling can be improved, the personalized requirements of brace design are met, and the matching degree between the obtained brace model and the limb of a patient can be improved. Moreover, the problems due to the fact that brace file information designed by the existing automatic generation design processes can only be used for simple model processing and cannot be practically applied to complex brace design are solved, the design time of brace manufacturing can be effectively shortened, and the brace design costs can be reduced.

一种弹性模量梯度桩核材料及其制备方法、弹性模量梯度桩核

Resumen de: CN120168151A

本发明公开了一种弹性模量梯度桩核材料及其制备方法，和采用该材料制备得到的弹性模量梯度桩核。本发明的制备方法首先通过临床扫描患者桩道形态，制备出形态大小匹配的桩核修复系统，进而通过模拟天然牙齿的弹性模量梯度分布，利用增材制造工艺制备出具有仿生功能梯度桩核系统，可以改善桩、桩‑牙齿界面及牙齿部位的应力分布情况，有利于延长桩核修复患牙的寿命。

一种多孔结构钽金属牙种植体及其加工方法

Resumen de: CN120168160A

本发明公开了一种多孔结构钽金属牙种植体及其加工方法，属于牙科口腔技术领域；包括包括纯钛实体部分和钽小梁部分；所述纯钛实体部分上设有自攻型螺纹；所述钽小梁部分为螺旋状结构；沿纯钛实体部分的自攻型螺纹设有用于嵌入钽小梁的螺旋槽；钽小梁部分位于对应的螺旋槽。本发明整体均匀的增加骨结合效果，减少骨结合时间，提高稳定性。

用于骨移植的具有管腔的装置

Resumen de: AU2023371660A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body with a proximal end and a distal tip, housing a scaffold with a porous structure distributed in proximal and distal lattices. The device includes an upper lumen in fluid communication with a first opening at the proximal end, and a lower lumen in fluid communication with a second opening at the proximal end. The device is configured to support independent delivery of cement and cells to the lattices. In some embodiments, the device is a bone screw with a thickened head-neck junction, designed to reduce the likelihood of rod breakage during installation. The methods involve implanting the device into a patient's bone, providing an innovative approach to fracture treatment.

一种3D打印钛合金复合涂层材料及其制备方法和应用

Resumen de: CN120174451A

本发明公开了一种3D打印钛合金复合涂层材料及其制备方法和应用，涉及钛合金材料技术领域。通过在3D打印钛合金基体上形成微弧氧化陶瓷涂层并原位生长Mn‑MOF材料，能够显著提高钛合金的生物相容性，该复合涂层不仅提高了3D打印钛合金基体的表面粗糙度，而且通过Mn的引入有效促进了细胞增殖和粘附，从而提高了钛合金在生物医用领域的应用潜力。

一种墨水直写3D打印陶瓷材料及其制备方法和应用

Resumen de: CN120168711A

本发明公开了一种墨水直写3D打印陶瓷材料及其制备方法和应用。所述制备方法包括步骤：制备得到氧化锆陶瓷浆料，所述氧化锆陶瓷浆料为粘弹性浆料，在剪切速率>10s‑1时，黏度＜100Pa·s，且浆料的屈服应力＞200Pa；按照预定的程序结构将所述氧化锆陶瓷浆料进行墨水直写3D打印，实现原位实时固化，得到三维陶瓷结构前体；将所述三维陶瓷结构前体进行烧结。本发明的制备方法通过优化氧化锆陶瓷浆料参数，经过墨水直写3D打印后，出料均匀，粘结强度好，烧结变形小，收缩率稳定，利于控制孔隙率，适用于打印不同填充比的陶瓷材料，便于模拟天然牙齿弹性模量梯度变化，得到更符合牙齿实际弹性模量分布的桩核修复系统。

在处理患者口腔中的牙齿状况的方法中使用的可固化组合物

Resumen de: WO2024110805A1

The invention relates to a curable composition for use in a process of treating a dental situation in the mouth of a patient, the curable composition comprising radiation-curable component(s), photo-initiator(s), the photo-initiator(s) exhibiting an absorption in the UV light region, and an absorption in the visible light region, the absorption in the UV light region being stronger than the absorption in the visible light region, optionally filler(s), optionally additive(s), the process comprising the steps of additive manufacturing a dental or orthodontic article layer-by-layer using radiation with a wavelength in the UV light region, attaching the dental or orthodontic article to a surface of hard dental tissue or a dental material, applying radiation with a wavelength in the visible light region to the dental or orthodontic article.

一种用于将药物精准递送至圆窗龛的个性化辅助植入物

Resumen de: CN120168221A

本发明公开了一种用于将药物精准递送至圆窗龛的个性化辅助植入物，包括设置于外耳道的主结构；所述主结构的一个底面位于骨性外耳道中部，朝向鼓膜及中耳，另一个底面位于外耳道开口；所述主结构的侧面的形状轮廓与患者外耳道的解剖结构相适配并机械性固定连接；所述主结构的两个底面之间设有中空的直线的输送通道，且所述输送通道的延长线对准内耳结构的圆窗龛；所述主结构采用生物相容性柔性材料制造。本发明能够避免传统的内窥镜引导下经鼓膜注射给药依赖医生手动操作，存在个体操作差异、解剖复杂性影响以及药物流失风险的问题，并且能够广泛应用于药物输送、造影剂及局部麻醉剂注射、基因治疗、生物传感器或微电极植入等领域。

PROSTHESIS FOR IN VIVO INSERTION UTILIZING A BIOCOMPATIBLE MATERIAL

Resumen de: KR20250090887A

생체적합성 재료를 활용한 체내 삽입용 보형물이 개시된다. 본 발명의 일측면에 따른 체내 삽입용 보형물은 인체에 삽입되는 체내 삽입용 보형물로서, 키토산(chitosan), 키틴(chitin), 폴리데옥시 리보뉴클레오티드(polydeoxyribonucleotide; PDRN), 폴리뉴클레오티드(polynucleotide; PN), 폴리카프로락톤(polycaprolactone; PCL), 수산화인회석(hydroxyapatite) 및 골형성단백질2(bone morphogenetic protein 2; BMP-2)로 이루어진 군으로부터 선택되는 적어도 하나의 생체적합성 재료를 함유하는 복수의 선부재를 포함할 수 있고, 여기서 상기 복수의 선부재는 서로에 대해 교차하도록 결합되어 3차원 구조를 구성할 수 있다.

3D Strontium-releasing hierarchically structured 3D-printed scaffolds for promoting osteochondrial regeneration and manufacturing method thereof

Resumen de: WO2025127798A1

The present invention relates to a strontium-emitting 3D printing scaffold for promoting bone cartilage regeneration and a method for manufacturing same. The scaffold continuously maintains the emission of a triad of ions including strontium (Sr), silicate (Si), and calcium (Ca) to promote cell migration to a damaged site, and has a hierarchical porous structure, and thus enhances tissue regeneration by increasing cell engraftment, immune regulation, and angiogenesis, and exhibits an excellent anti-inflammatory effect. Therefore, the scaffold can be effectively used for the regeneration of damaged bone and cartilage tissue.

一种压阻传感器阵列及其制备方法

Nº publicación: CN120176914A 20/06/2025

Solicitante:

西北工业大学宁波研究院

Resumen de: CN120176914A

本发明提供一种压阻传感器阵列及其制备方法，属于柔性传感器技术领域，与现有技术相比，本发明具有器件可拉伸特性，压阻传感器具有抗应变干扰稳定性。采用光固化3D打印技术，制备出软硬结合的基底结构，使压阻传感器阵列具备本征可拉伸性，有助于适应复杂形变环境；通过设计负泊松比岛桥结构，显著提升了器件的整体拉伸性能，确保其在大应变下的可靠性；结合PU/MXene敏感材料和传感层微观圆锥结构的优化设计，大幅提高了传感器在压力加载时的电信号灵敏度，实现了更精确的力学响应；同时，利用3D打印技术制备的传感器阵列相比传统制备方法更加高效，工艺流程简单且易于规模化生产，具有显著的优势。