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175
resultados
Última actualización
18/09/2025 [07:12:00]
Resultados 100 a 125 de 175
Resumen de: US2025269083A1
A hollow embolic microsphere, a preparation method, and a pharmaceutical composition and use thereof, wherein: the hollow embolic microsphere is a microsphere prepared using a polymer material and having a unique shape and structure, and is suitable for transcatheter arterial embolization. The hollow embolic microsphere of the present disclosure can enter channels having different sizes, and has embolization effects on various target positions. The hollow microsphere is internally porous and has drug loading abilities, and drug release when loading drug can be easily controlled and the treatment effect is good. No emulsifier or surfactant is needed in the preparation of the hollow microsphere, reaction conditions are mild, and the process is simple. The obtained microsphere has a uniform shape and a controllable size, and is capable of controlling the embolization time. Various drugs including protein heat-sensitive drugs can be loaded, and the drug encapsulation efficiency can reach more than 70%.
Resumen de: US2025269094A1
Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.
Resumen de: US2025268756A1
A tissue-augmented corneal inlay surgery technique is disclosed herein. In one embodiment, the surgery method includes the steps of: (i) implanting a corneal inlay into a recipient cornea of an eye of a patient; (ii) applying laser energy to a central portion of the corneal inlay and a portion of stromal tissue of the recipient cornea underneath the corneal inlay so as to modify the refractive power of the eye; (iii) applying a cross-linking solution that includes a photosensitizer to the recipient cornea of the eye of the patient; and (iv) irradiating the corneal inlay and surrounding corneal tissue so as to activate cross-linkers in the corneal inlay and the surrounding corneal tissue. In this embodiment, the central portion of the corneal inlay remains clear for the patient without being obstructed by swollen tissue so that the patient is able to see immediately after the corneal inlay surgery.
Resumen de: US2025268718A1
Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.
Resumen de: US2025269402A1
Systems and methods are provided for applying visualization features to one or more expandable members. In some embodiments, a modular rack system is provided that is configured to receive one or more expandable members. The modular rack system comprises one or more elongate rods assemblies, with each rod assembly being sized and shaped to receive a single expandable member. An inking system is configured to apply one or more visualization features on the one or more expandable members. The one or more visualization features are applied to each of the one or more expandable members such that each of the one or more expandable members has identical visualization features thereon.
Resumen de: US2025268690A1
A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.
Resumen de: US2025270502A1
Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.
Resumen de: US2025270389A1
The present invention relates to a stretchable self-healing hydrogel. The hydrogel has excellent mechanical properties and stability, and stretchable and self-healing properties, and can be useful as a hydrogel for delivery of a drug or a cell, and a composition for 3D bioprinters.
Resumen de: US2025270291A1
The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.
Resumen de: US2025269656A1
A coupling member includes a valve housing and a hollow movable valve. Relative to the valve housing, the hollow movable valve is positionally displaced in an axis direction between a position in a connected state where the coupling member is connected to another coupling member and a position in a disconnected state where the coupling member is disconnected from the other coupling member, thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap is generated between a prescribed part of the hollow movable valve and the valve housing in a radial direction. The hollow movable valve has a circulation opening penetrating through the prescribed part in the radial direction.
Resumen de: US2025269599A1
Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a rotor configured to support a plurality of additively manufactured objects having excess material thereon. The system can further include an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects. The system can further include a sensor configured to obtain sensor data indicative of a cleaning status of the plurality of additively manufactured objects while the plurality of additively manufactured objects remain on the rotor. The system can further include a controller configured to adjust, based on the sensor data, an operational parameter of the rotor that enhances removal of the excess material from the plurality of additively manufactured objects.
Resumen de: US2025269585A1
Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HIB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.
Resumen de: DE102024105696A1
Die Erfindung betrifft einen Referenzkörper (1) zum Bestimmen einer Abschwächung von Röntgenstrahlung durch ein mittels Röntgenstrahlung untersuchtes Objekt, wobei der Referenzkörper (1) eine zusammenhängende Matrix (2) aus einem Kunstharz mit zugesetztem Röntgenkontrastmittel aufweist. Um einen Referenzkörper (1) anzugeben, welcher in einer Röntgenaufnahme sowohl eine hohe Röntgenkontrastauflösung, als auch eine hohe Ortsauflösung erlaubt, wird vorgeschlagen, dass die Matrix (2) 3D-gedruckt wird, wobei mindestens ein erster Bereich (3, 4, 5, 6,7) und ein zweiter Bereich (3, 4, 5, 6 7) der Matrix (2) definiert werden, indem das Röntgenkontrastmittel dem Kunstharz in dem ersten Bereich (3, 4, 5, 6, 7) in einer ersten definierten Konzentration und in dem zweiten Bereich (3, 4, 5, 6, 7) in einer von der ersten definierten Konzentration abweichenden zweiten definierten Konzentration zugesetzt wird, so dass der erste Bereich (3, 4, 5, 6, 7) einen ersten definierten Röntgenkontrast mit einer ersten CT-Zahl aufweist, welche sich von einer zweiten CT-Zahl eines zweiten definierten Röntgenkontrasts des zweiten Bereiches (3, 4, 5, 6, 7) um mindestens 1 HU unterscheidet.
Resumen de: WO2025178505A1
The invention relates to a recombinant hybrid protein REC2z with a structure as defined in the description, recombinant DNA sequences encoding this protein, vectors containing the recombinant DNA sequences, and eukaryotic and prokaryotic expression systems using the in vitro recombinant DNA sequences described below. The invention also relates to the use of the recombinant hybrid protein REC2z as a component of bioink for bioprinting and also as a component of biomaterials. In addition, the invention relates to the use of recombinant DNA sequences, expression vectors and expression systems to produce the recombinant hybrid protein REC2z. The invention finds applications in bioprinting, medicine and cell and tissue engineering.
Resumen de: WO2025178922A1
A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.
Resumen de: CN120112315A
The present disclosure provides devices including a therapeutic agent coupled to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for making the device and their use, for example, in treating a condition of a subject in need thereof.
Resumen de: WO2025179212A1
Many embodiments are directed to systems and methods for 3D printing. Many embodiments utilize a print head modeled after a concentric tube robot (CTR). Certain embodiments provide a print bed allowing for collaborative printing and can include ports to allow numerous degrees of freedom from a print head without loss of a print bed solution. Further embodiments allow printing within irregular print beds, including printing within an injection mold. Certain embodiments of print heads possess multiple nozzles and/or internal tubes to allow for additional geometries. Certain embodiments are directed to print nozzles allowing for multiple material printing, and optionally on-the-fly material switching. Certain embodiments are directed to uses of bioprinting, including in vivo printing of devices, while additional embodiments allow for pipeline type printing, such that the printed part continually and/or continuously moves through a path during the printing process.
Resumen de: WO2025179194A1
Systems and methods are provided for applying visualization features to one or more expandable members. In some embodiments, a modular rack system is provided that is configured to receive one or more expandable members. The modular rack system comprises one or more elongate rods assemblies, with each rod assembly being sized and shaped to receive a single expandable member. An inking system is configured to apply one or more visualization features on the one or more expandable members. The one or more visualization features are applied to each of the one or more expandable members such that each of the one or more expandable members has identical visualization features thereon.
Resumen de: EP4606354A1
Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an intermedullary implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.
Resumen de: EP4606583A1
A coupling member (1) includes a valve housing (12) and a hollow movable valve (101). Relative to the valve housing (12), the hollow movable valve (101) is positionally displaced in an axis direction between a position in a connected state where the coupling member (1) is connected to another coupling member (2) and a position in a disconnected state where the coupling member (1) is disconnected from the other coupling member (2), thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap (G) is generated between a prescribed part of the hollow movable valve (101) and the valve housing (12) in a radial direction. The hollow movable valve (101) has a circulation opening (1010) penetrating through the prescribed part in the radial direction.
Resumen de: EP4606824A1
An object of the present invention is to provide a photopolymerization initiator that is hardly affected by inhibition by oxygen, has good photoinitiating property in air, has high sensitivity to long-wavelength light, and can suppress odor and bleed-out problems of a cured product to be obtained.A photopolymerization initiator having one or more benzophenone groups and one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms in a molecule, wherein one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms are bonded to one or more carbon atoms of an aryl group of one or more benzophenone groups through a carboxylic acid ester group or a carboxylic acid amide group.
Resumen de: CN120225338A
Aspects of the present disclosure include methods for making polymer structures having microvoid spaces. A method according to certain embodiments includes irradiating a polymerizable composition positioned between a build lift table and a build surface to produce such polymerizable composition, the polymerizable composition has: a polymerized region of the polymerizable composition having a microvoid space in contact with a build lift table and a non-polymerized region of the polymerizable composition in contact with a build surface; removing the build lift from the build surface; contacting the generated microvoid space with a non-reactive composition; and repeating in a manner sufficient to create a polymer structure having a clearly discernible microvoid space. Systems for preparing polymer structures according to the subject methods are also described. Also provided are polymer structures having clearly discernible microvoid spaces, such as where the microvoid spaces are filled with a non-polymerizable composition.
Resumen de: WO2024083825A1
A hollow body and a process for preparing a hollow body having a bottom, an upper end wall and side walls extending between the bottom and the upper end wall, characterized in that the upper end wall and side walls are made of metal, the cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter and the upper end wall comprises at least one opening. The hollow body are suitable for encapsulating small amounts of liquid, or of very small micro-electromechanical system, may be used for the controlled release of pharmaceutical components.
Resumen de: CN120091914A
The present disclosure relates to an aqueous bio-ink solution for light-based bioprinting applications comprising: (a) from 0.5% to 95% by weight of a water-soluble prepolymer; (b) from 0.001% to 5% by weight of a biocompatible metal acyl phosphinate photoinitiator; (c) from 0.001 wt% to 10 wt% of a biocompatible light absorber; and (d) from 5% to 99.5% by weight of a solvent. The present disclosure also relates to methods of using aqueous bio-ink solutions containing living cells and methods of using aqueous bio-ink solutions free of living cells (cell-free).
Nº publicación: EP4604872A1 27/08/2025
Solicitante:
ALIGN TECHNOLOGY INC [US]
Align Technology, Inc
Resumen de: CN120076767A
Systems, methods, and devices are provided for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances. In some embodiments, a method includes receiving a treatment plan for teeth of a patient, the treatment plan specifying a target arrangement of teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method may include identifying appliance design parameters of one or more dental appliances for performing at least one of a plurality of treatment phases. The appliance design parameters may include one or more manufacturability parameters corresponding to an additive manufacturing process to be used for directly manufacturing the one or more dental appliances. The method may also include determining an appliance geometry of the one or more dental appliances using the set of appliance design parameters.
BOPI
Sede Electrónica
