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DEVICE FOR TREATING SNORING AND APNEA

Resumen de: WO2025097229A1

The present invention relates to a dental device for treating snoring and apnea (1) which is made using a 3D digital model and 3D printers and is composed of an upper plate (4) and a lower plate (6) that are joined by interlocking mechanisms (8, 9) that limit the opening of the mouth, optimizing the results of the treatment for snoring and apnea. The device is an apparatus for bringing the lower jaw forward that does not contain metal elements incorporated into the design of the apparatus, making manufacture easier and cheaper, as well as making the device more hygienic. Additionally, the forward movement of the lower jaw (7) is not achieved using screws or metal wires, but rather by sequentially and incrementally changing the plates, thus increasing the caliber of the airways, wherein the forward movement results from changes in the positioning of the interlocking mechanisms (8, 9).

Strahlungshärtende Zusammensetzung für die Herstellung dentaler Bauteile in einem 3D-Druck-Verfahren

Resumen de: DE102023131266A1

Die Erfindung betrifft ein strahlungshärtende Zusammensetzung für die Herstellung dentaler Bauteile in einem 3D-Druck-Verfahren, umfassend bezogen auf die Gesamtmasse der strahlungshärtenden Zusammensetzung: i) ein oder mehrere radikalisch polymerisierbare Monomere in einem kombinierten Massenanteil von 30 % oder mehr, ii) einen oder mehrere erste Füllstoffe in einem kombinierten Massenanteil von 5 % oder mehr, wobei der oder die ersten Füllstoffe einen mittleren Partikeldurchmesser D50 von 150 nm oder weniger aufweisen, iii) einen oder mehrere vom ersten Füllstoff verschiedene zweite Füllstoffe in einem kombinierten Massenanteil von 5 % oder mehr, wobei der oder die zweiten Füllstoffe ausgewählt sind aus der Gruppe bestehend aus Feldspaten, und iv) einen oder mehrere Photoinitiatoren mit einem kombinierten Massenanteil im Bereich von 0,001 bis 10 %, wobei der kombinierte Massenanteil an Füllstoffen 30 % oder mehr beträgt.

SYSTEMS AND METHODS TO REPAIR TISSUE DEFECTS

Resumen de: US2025151975A1

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

3D Segmented Cranial Correction Helmet Using 3D Printing

Resumen de: KR102807975B1

본 발명은 착용자의 두상에 맞게 헬멧의 외피와 내피를 교체할 수 있도록 설계된 헬멧으로,헬멧의 경질 외피와 체결 구조를 통해 착용 중 안정성을 유지하면서도 두상 교정이 가능하도록 고안된 3D 프린팅 기반의 장치에 관한 것으로, 착용자의 머리 전단을 덮고 안착되는 3D 프린팅을 이용하여 제작되는 경질의 제1 외피부; 상기 제1 외피부의 후단에 맞물려 체결되며, 착용자의 머리 후단을 덮고 안착되는 3D 프린팅을 이용하여 제작되는 경질의 제2 외피부; 상기 제1 외피부와 상기 제2 외피부의 각 측면 사이에 설치되어 상기 제1 외피부와 상기 제2 외피부를 상호 체결하는 외피 체결부; 착용자의 두상 교정을 위해 상기 제1 외피부의 내향면에 설치되는 연질의 제1 내피부; 착용자의 두상 교정을 위해 상기 제2 외피부의 내향면에 탈부착 가능하도록 설치되는 연질의 제2 내피부; 및 착용자의 두상이 커짐에 따라 보다 작은 두께로 교체 가능하도록 상기 제2 외피부와 상기 제2 내피부 사이에 설치되는 다양한 두께로 구비되는 중간부;를 포함한다.

METHOD FOR PREPARING HOMOGENEOUS COLLAGEN SUSPENSION, USE OF HOMOGENEOUS COLLAGEN SUSPENSION, METHOD FOR PREPARING COLLAGEN-BASED HYDROGEL MATERIALS, METHOD FOR PREPARING COLLAGEN FILM AND/OR LAYER AND/OR SUBSTRATE FOR CULTURE, METHOD FOR PREPARING COLLAGEN PRINT-OUTS, AND METHODS FOR PREPARING POROUS COLLAGEN SHAPES

Resumen de: EP4553104A1

An object of the invention is a method for obtaining a homogeneous collagen suspension, characterized in that it comprises the following stepsI. to collagen, with mixing, preferably on a vortex, a solution composed of a mild organic solvent and a buffer, with the addition of acids is added wherein:- as the collagen preferably type I collagen is used, preferably it is the collagen derived from bovine tendons,- the concentration of the collagen with respect to the solvent is in the range of 0.1 to 15% w/v,- the organic solvent is a solvent exhibiting low surface tension relative to the collagen, preferably the solvent is a solvent for which the contact angle value for collagen is below 20°, most preferably the organic solvent is dimethyl sulfoxide (DMSO),- the buffer is a buffer containing salts naturally occurring in a living organism, preferably the buffer is a phosphate buffer (PBS),- the solvent and the buffer can be mixed together in various proportions, preferably the solvent and the buffer are mixed in a ratio of 5 parts of the solvent to 1 part of the buffer, by volume, most preferably 5 parts DMSO to 1 part PBS, by volume,- the acids are HCl and HF, wherein the concentration of each of the acid in the solution is not higher than 0.1 M,II. subsequently, the solution obtained in step I. is mixed at a temperature of 2 - 8°C, preferably 4 - 6°C, for a period of 3 to 7 days, preferably for a period of 3 days,III. subsequently, the solution obtained in step II., while mix

PARTIALLY TRABECULAR ELEMENT FOR AUGMENT OR BONE FILLER

Resumen de: AU2023303676A1

Element (100, 200, 300) for augment or bone filler, comprising at least one first outer-layer portion (101) having a trabecular lattice of metallic material, and further comprising at least one reinforcing inner layer (103) of metallic material having a plurality of channel structures (104) arrayed with respective channel openings (105) delimited by edges in structural contact with the at least one first outer-layer portion (101).

3D PRINTABLE MATERIAL FOR THE FABRICATION OF PRINTED DENTAL ATTACHMENTS AND DENTAL ATTACHMENT PLACEMENT DEVICES

Resumen de: US2024016579A1

Disclosed herein are dental attachment placement devices generated from curable compositions by additive manufacturing. The curable compositions contain a high crosslinker content, and after curing, yield tough and color neutral materials suitable for dental attachment placement devices.

BIOGLASS FIBER REINFORCEMENT OF ADDITIVELY MANUFACTURED POLYMERS

Resumen de: US2024016578A1

Disclosed herein are methods for manufacturing medical devices, such as implants, joint replacements, graft materials, augmentation materials, prosthetic materials, etc., from solid material reinforced curable resins. Methods of repositioning a patient's teeth using such medical devices are also provided.

METHOD FOR MANUFACTURING TRANSPARENT ORTHODONTIC DEVICE BY USING 3D PRINTER

Resumen de: EP4552608A1

This invention provides a more efficient, cost-effective, and streamlined method for manufacturing transparent orthodontic devices by utilizing 3D printing technology. It simplifies the production process, reduces collaboration time, and ensures that the aligners are customized for the patient's specific orthodontic needs.

一种用于细胞3D打印的高强度光敏生物墨水水凝胶及其制备方法

Resumen de: CN119971134A

本发明涉及一种用于细胞3D打印的高强度光敏生物墨水水凝胶及其制备方法，属于生物材料技术领域。该方法直接采用高强度材料NAGA为生物墨水水凝胶提供高强度，通过3D打印载细胞生物活性墨水，实现生物活性和高强度的兼顾。并在绿光下进行交联以避免光照对细胞的损伤，通过在生物墨水中抗氧化剂以避免光引发剂产生的自由基对细胞的攻击，最终实现用于细胞3D打印的高强度光敏生物墨水水凝胶制备。本发明制备得到的生物墨水水凝胶，可以实现高的力学性能和生物(细胞)活性的兼顾，有效的避免紫外光对于细胞的损伤，解决了长时间光照下光引发剂产生的自由基对细胞的损伤的问题。

一种使用3DFP增材制造的具有梯度结构的生物陶瓷骨支架制备方法

Resumen de: CN119977560A

本发明公开了一种使用3DFP增材制造的具有梯度结构的生物陶瓷骨支架制备方法；包括：设计生物梯度结构模型；配备包含纳米氧化锆、磷酸三钙、羟基磷灰石和氧化银粉末的丝材原料，混合制浆，制备丝材；将制备的丝材加入打印机中，按切片路径完成梯度结构的逐层打印，获得支架坯体；热处理，之后随炉冷却至室温，即得所述生物陶瓷骨支架。本发明通过深层次优化丝材原料的组成配比，提升支架材料的机械强度；与此同时通过成分梯度和结构梯度双重设计，在保证密质骨高强度、硬度、抗弯性的基础上内层设计成分与结构不同的松质骨，借此来保证支架与组织或细胞有效地相互作用，促进骨细胞的黏附、增殖和分化，有助于组织修复和再生。

一种生物陶瓷支架及其制备方法和应用

Resumen de: CN119977543A

本发明提供了一种生物陶瓷支架及其制备方法和应用，属于组织修复材料技术领域。本发明通过DLP光固化3D打印技术，将具有与人体骨相近的抗压强度以及适中的降解速率的镁黄长石，设计出了一种用于提升骨组织修复的生物陶瓷支架，且机械强度和孔隙率及支架结构满足骨修复支架要求。本发明利用DLP光固化3D打印技术制备了一种新型多孔生物陶瓷支架，探索了支架形态、固含量、烧结参数对骨修复支架机械性能的影响，最终制备得到机械性能高的骨修复效果优异的生物陶瓷支架。

用于利用眼透镜控制轴向生长的装置和方法

Resumen de: US2024408834A1

One embodiment of an ocular lens includes a lens body configured to contact an eye where the lens body has an optic zone shaped to direct central light towards a central focal point of a central region of a retina of the eye. At least one optic feature of the lens body has a characteristic that directs peripheral light off axis into the eye away from the central region of the retina. Another embodiment of an ocular lens has at least one isolated feature of the lens body that has a characteristic of directing peripheral light off axis into the eye away from the central region of the retina. Methods of making contact lenses include forming the features during the manufacturing process.

用于简化口腔骨增量手术4D打印支架的制备方法及应用

Resumen de: CN119971138A

本发明适用于口腔种植学技术领域，提供了用于简化口腔骨增量手术4D打印支架的制备方法及应用。本发明利用4D打印技术，将聚多巴胺和海藻酸钠混合打印成水凝胶支架，经锶离子交联后，该支架展现出优异的生物可降解性和生物相容性，可替代钛网弯曲支架，有效维持成骨空间，并降低种植骨增量手术的高技术敏感度。该支架能精准适配不同骨缺损轮廓，提供支撑并加速愈合，降低并发症风险。其适配性强、植入简便，能最大程度减少不必要的组织剥离与损伤，缩短手术时长，利于患者术后恢复。在水平骨增量手术中，该支架能为后续牙种植等修复手段提供坚实的骨基础。形变产生的机械信号与支架释放的生物活性成分协同作用，加快骨组织再生。

一种3D生物打印的促血管化膀胱补片及其制备方法

Resumen de: CN119971139A

本发明属于生物医学领域，具体涉及一种3D生物打印的促血管化膀胱补片及其制备方法。本发明将所制备的GelMA与Laponite聚合，制备出GelMA‑Laponite水凝胶，然后利用3D生物打印机器在膀胱脱细胞基质上将GelMA‑Laponite水凝胶和种子细胞混合打印为具有三维空间结构的GelMA‑Laponite支架，支架使用紫外光交联，得到双层血管化膀胱补片。本发明有望提升组织工程化膀胱补片的构建水平，解决组织工程膀胱移植物的血管化问题，为推动膀胱组织工程的临床应用进程奠定了良好的理论基础与技术支撑。

一种3D打印骨小梁口腔种植体的方法

Resumen de: CN115740495A

The invention relates to a method for 3D printing of a bone trabecula oral implant. The bone trabecula oral implant comprises an implant base body and a bone trabecula porous structure which are integrally formed. The bone trabecula porous structure is positioned in the axial middle section of the implant base body; and the implant base body is provided with an external thread. The printing method comprises the following steps: obtaining an oral implant 3D model with a bone trabecula porous structure through three-dimensional design software; carrying out molding manufacturing, sand blasting and annealing treatment by utilizing an SLM technology to obtain a bone trabecula oral implant primary product; and forming a tantalum metal coating on the surface of the primary product of the bone trabecula oral implant by using a vapor deposition technology to obtain the bone trabecula oral implant with the tantalum coating. The bone trabecula oral implant obtained by the method is high in density and mechanical strength, favorable for the implant to exert a good repairing effect, and excellent in application prospect.

硫醇-烯水凝胶

Resumen de: AU2023345391A1

There is provided a hydrogel string for encapsulating a biological material. The hydrogel string has a thiol-ene crosslinked polymer with a first side-chain functionalized backbone polymer functionalized with an activated alkene crosslinked with a free or protected thiol-containing group present on a second side-chain functionalized backbone polymer. The biological material is encapsulated within the thiol-ene crosslinked polymer.

Method for preparing a homogeneous collagen suspension, application of the homogeneous collagen suspension, method for preparing collagen-based hydrogel materials, method for producing collagen film and/or layer and/or substrate for cultivation, method for producing collagen prints, and methods for producing porous collagen shapes.

Resumen de: EP4553104A1

An object of the invention is a method for obtaining a homogeneous collagen suspension, characterized in that it comprises the following stepsI. to collagen, with mixing, preferably on a vortex, a solution composed of a mild organic solvent and a buffer, with the addition of acids is added wherein:- as the collagen preferably type I collagen is used, preferably it is the collagen derived from bovine tendons,- the concentration of the collagen with respect to the solvent is in the range of 0.1 to 15% w/v,- the organic solvent is a solvent exhibiting low surface tension relative to the collagen, preferably the solvent is a solvent for which the contact angle value for collagen is below 20°, most preferably the organic solvent is dimethyl sulfoxide (DMSO),- the buffer is a buffer containing salts naturally occurring in a living organism, preferably the buffer is a phosphate buffer (PBS),- the solvent and the buffer can be mixed together in various proportions, preferably the solvent and the buffer are mixed in a ratio of 5 parts of the solvent to 1 part of the buffer, by volume, most preferably 5 parts DMSO to 1 part PBS, by volume,- the acids are HCl and HF, wherein the concentration of each of the acid in the solution is not higher than 0.1 M,II. subsequently, the solution obtained in step I. is mixed at a temperature of 2 - 8°C, preferably 4 - 6°C, for a period of 3 to 7 days, preferably for a period of 3 days,III. subsequently, the solution obtained in step II., while mix

3 POROUS THREE DIMENSIONAL MENISCUS SCAFFOLD AND BIODEGRADABLE MEDICAL DEVICE INCLUDING THE SAME

Resumen de: WO2025095385A1

The present invention relates to a porous three-dimensional meniscus scaffold and a biodegradable medical device comprising same. According to the present invention, external force applied to the meniscus scaffold can be more reliably and evenly dispersed by appropriately adjusting a ratio of intervals between fibers inside the meniscus scaffold, and thus the biodegradable medical device comprising the meniscus scaffold has greater structural stability.

SYSTEM AND METHOD FOR PRODUCING PHARMACEUTICAL OBJECTS VIA 3D PRINTING

Resumen de: EP4523890A2

The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D printing. The system comprises a 3D printing machine (2) with a mechanical system (3) movable in one or more directions, at least one print head (5) with at least one nozzle (37) being movable by the mechanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5) and comprising formatted print locations (49) on the base (6) for shaping the pharmaceutical object. The formatted print locations (49) can be adapted to receive a blister such that the pharmaceutical objects can be printed directly inside the blister. The system can further comprise a closing device for applying a sealing membrane or film to hermetically seal the blister after the printing is completed. The invention further relates to a method for producing pharmaceutical objects with the system.

透明美白トレイの製造方法｛Ａ Ｍａｎｕｆａｃｔｕｒｉｎｇ ｍｅｔｈｏｄ ｏｆ ｔｒａｎｓｐａｒｅｎｔ ｏｒｔｈｏｄｏｎｔｉｃｓ ｄｅｖｉｃｅ｝

Resumen de: CN118922292A

The transparent whitening denture manufacturing method according to the present invention comprises: printing a transparent whitening denture by using a 3D printing technique by using a composition special for forming a transparent whitening denture as a raw material (S10); removing the uncured resin and liquid in the transparent whitening denture obtained in the step (S10) (S20); (S30) performing post-curing on the transparent whitening denture obtained in the step (S20); performing post-heat treatment on the transparent whitening denture obtained in the step (S30) (S40); and cleaning the transparent whitening denture obtained in the step (S40) (S50).

一种可同时打印多种牙色的牙齿修复体的装置及其方法

Resumen de: CN119952966A

本申请涉及打印技术领域，提供一种可同时打印多种牙色的牙齿修复体的装置及其方法，以解决现有的3D打印技术在用于打印不同牙色的牙齿修复体时，无法平衡对牙齿修复体的制造成本与制造效率的问题。其包括：打印平台，其具有多个打印区域；料槽座，其上开设有与所述打印区域相匹配的料槽，每个所述料槽用于放置不同色号的打印材料。

生物打印的软组织增强支架

Resumen de: AU2023346376A1

The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.

一种纳米纤维复合支架及其制备方法与应用

Resumen de: CN119950810A

本发明公开了一种纳米纤维复合支架及其制备方法与应用，所述制备方法包括以下步骤：S1：将含有无机源的溶液与模板聚合物溶液混合均匀，得到纺丝前驱体溶液；利用纺丝前驱体溶液进行纺丝，得到前驱体纳米纤维；前驱体纳米纤维经预氧化和碳化后得到无机纳米纤维；S2：将步骤S1所述无机纳米纤维在第一分散介质中分散并进行干燥，得到纳米短纤维；S3：将S2所述纳米短纤维用第二分散介质重悬，得到短纤维分散液；S4：将步骤S3所述短纤维分散液通过静电喷涂逐层喷涂在3D打印支架上，得到纳米纤维复合支架。本发明提供的纳米纤维复合支架有良好的力学性能、生物相容性、光热性能和光热抑菌性。

3D Method for Optimizing Percutaneous Pulmonary Valve Implantation Using Patient-Specific Model Through 3D Printing and in vitro Mock Circulation

Nº publicación: KR20250064597A 09/05/2025

Solicitante:

서울대학교병원

Resumen de: KR20250064597A

본 발명은 경피적 폐동맥 판막 삽입의 성공률을 높이기 위해 최적의 경피적 폐동팩 판막 크기와 삽입 위치를 찾도록 하는 3D 프린팅을 통한 환자맞춤형 모델과 체외 모의 순환을 이용해 경피적 폐동맥 판막 삽입을 최적화하는 방법에 관한 것이다. 이에 따른 본 발명은, 심장 컴퓨터 단층 촬영(computed tomography,CT)을 수행하여 CT 영상을 수득하는 단계; CT 영상을 기반으로 심장 및 혈관을 세분화하여 3차원 모델링을 시행한 후 3D 프린팅 파일 포맷을 생성하는 단계; 3D 프린팅 파일을 이용해 3D 프린팅하여 촬영 대상 사람의 우심실 유출로에 대응한 유출로 모형(10)을 제작하는 단계를 포함하여 구성된다.