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SYSTEMS AND METHODS FOR CELL QUANTIFICATION IN BIOPRINTING

Resumen de: WO2026053002A2

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material during and/or after passage of the plurality of cells through the bioprinting system. A computing system may generate, via a machine learning algorithm executing on the image data, a plurality of segmented regions in the image data, wherein each segmented region in the plurality of segmented region defines a boundary around a different set of cell aggregates in the plurality of cells, identify a first segmented region in the plurality of segmented regions that defines a boundary around at least a visible portion of a first cell aggregate, wherein the first cell aggregate includes an occluded portion, determine, based on an estimated shape of the first cell aggregate, an extrapolated boundary around at least some of the visible portion of the first cell aggregate and at least some of the occluded portion of the first cell aggregate, compute a quantity of cells within the first cell aggregate based on an area surrounded by the extrapolated boundary, and determine one or more parameters associated with the plurality of cells, the material flow, or the bioprinting system based on the quantity of cells.

SYSTEM AND METHOD FOR PLANNING AND SIMULATING A SURGICAL OPERATION TO CREATE A PATIENT-SPECIFIC SPINAL IMPLANT

Resumen de: WO2026054808A1

A system and method for planning and simulating a surgical operation to create a patient-specific spinal implant are disclosed. The system comprises a remote server configured to receive patient-specific medical image data and generate a 3D mesh model of the patient's spine using algorithms that separate vertebral bodies, remove artifacts, and smooth surfaces. A doctor's computer receives the 3D mesh model and allows real-time manipulation of intervertebral spaces to achieve a desired spinal curvature. The server generates a spinal implant design with surface-mapped endplates matching the patient's vertebral anatomy, which is transmitted to a 3D printer for manufacturing. The method includes steps of receiving image data, generating and updating the 3D mesh model based on doctor input, generating the final implant design, and transmitting it for production. The invention enables the creation of patient-specific spinal implants with improved conformity and surgical outcomes.

ANATOMICAL BELOW-KNEE PROSTHETIC LEG THAT CAN BE FABRICATED WITH A 3D PRINTER

Resumen de: WO2026054745A1

The invention relates to an anatomical below-knee prosthetic leg that can be fabricated with a 3D printer, which has a complex geometry optimised according to stress regions by means of structural analyses considering engineering calculations and various loading conditions in daily life with a topology optimization method, for below-knee amputee patients.

3D Tooth movement system using 3d printers

Resumen de: KR102939008B1

본 발명은 턱관절과 이갈이 환자의 치아이동을 위한 3D 프린팅 치아교정장치에 있어서, 특히 치아 교정기의 상부에 일정두께만큼 더 쌓도록하여 치아 교정기의 훼손을 방지함은 물론 일정두께로 윗치아와 아랫치아를 들어올림으로서 턱관절과 이갈이 환자의 치료에 도움을 줄 수 있도록 구성한 것을 특징으로 하는 턱관절과 이갈이 환자의 치아 이동을 위한 3D 프린팅 치아교정장치에 관한 것으로, 환자의 치아 교정이 필요한 스캔 데이터를 저장하며, 탑재한 3D 캐드 프로그램을 이용하여 상기 스캔 데이터에 대한 치아 모형을 3D로 모델링한 후 3D로 모델링된 치아 모형을 상기 3D 캐드 프로그램 하에서 교정 데이터가 반영되는 3D 치아 교정 데이터를 생성하여 저장하며, 상기 3D 치아 교정 데이터에 기초하는 환자의 치아 교정기설계를 완료하는 치아 교정기 설계 장치부(110); 및 상기 치아 교정기 설계 장치부(110)로부터 환자의 치아 교정기 설계 정보를 제공받고, 형상기억 폴리머(shape memory polymer: SMP) 또는 타이타늄 합금(Ti alloy)을 재료로 상기 치아 교정기 설계 정보에 맞춰 치아 교정기를 가공 처리하는 3D 프린터 장치부(120)를 포함하여 구성함이 특징이다.

SYSTEM AND METHOD FOR PERFORMING QUALITY ANALYSIS FOR MULTIDIMENSIONAL PRINTING

Resumen de: US20260070279A1

A system for performing quality analysis for multidimensional printing. The system includes a multidimensional printer, wherein the multidimensional printer comprises a printing head, a printing surface, an axis system and a scale, wherein the scale is arranged to measure weight applied on the printing surface; and a control unit operatively coupled to the multidimensional printer. The control unit is configured to control the printing head to extrude a printing material, to produce a printed object on the printing surface, obtain, from the scale, a weight of the printed object, and store the weight of the printed object in a memory associated with the control unit, compare the weight with a reference weight of the printed object, and control the printing head to stop extrusion of the printing material when the weight is equal to or exceeds the reference weight.

METHODS OF FABRICATING LASER-SINTERED CARBOHYDRATE MATERIALS AND COMPOSITIONS AND USES THEREOF

Resumen de: US20260070282A1

A composition useful in forming a structure in the form of a substantially interconnected vascular network. The composition includes a powder including a carbohydrate powder and an anti-caking agent, where the powder: has a granular form, and has a specific energy of less than 6 millijoules per milliliter (mJ/mL).

TWO-PHASE 3D PRINTING OF BIOCOMPATIBLE STRUCTURES

Resumen de: US20260069744A1

A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold; and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.

SYNTHETIC BONE GRAFTS AND METHODS FOR THEIR PREPARATION

Resumen de: US20260069746A1

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order.The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

TIBIA IMPLANT

Resumen de: US20260069422A1

A tibia implant for joint replacement has a plateau section and an anchor section projecting from a tibia-facing side of the plateau section. The anchor section is insertable into a channel in a tibia bone. The plateau section has a first surface structure that is a porous open-pore surface structure with bridges, webs or wall regions that can be gripped from behind in the axial direction on the tibia-facing side that comes into contact with tibia bone tissue. The open-pore surface structure has a first roughness. The anchor section is connected to the plateau section in a first axial anchor region on the circumferential side has a surface structure with a second roughness that is lower than the first roughness. The anchor section has a second axially free-ending axial anchor region with a smooth surface in the axial direction adjacent to the first axial anchor region.

DESIGN METHOD OF TRANSPARENT ORTHODONTIC DEVICE AND ATTACHMENT FOR ORTHODONTICS

Resumen de: EP4706587A1

The method for designing a transparent orthodontic appliance and attachment for tooth alignment according to the present invention has been devised to solve the above technical problems. It is a method for designing an orthodontic appliance using a computer, comprising: a step (S01) of designing the shape of an attachment to be affixed to the surface of a tooth model; a step (S02) of designing the inner surface shape of the transparent orthodontic appliance corresponding to the attachment designed in step S01; and a step (S03) of outputting the transparent orthodontic appliance by means of a 3D printer. The attachment comprises: two pressure surfaces (101) formed to face each other; two inclined surfaces (201) formed to be inclined toward each other while contacting the two pressure surfaces (101); a top surface (301) contacting the edges of the two pressure surfaces (101) and the two inclined surfaces (201); and an attachment surface (401) affixed to the surface of a tooth. This configuration serves as the technical means for solving the problem.

METHOD FOR MANUFACTURING ORTHODONTIC DEVICE BY USING INSERTION PATH

Resumen de: EP4706586A1

The present invention relates to a program for designing an orthodontic appliance. The method comprises: displaying, on a screen, the insertion path for determining the insertion direction of the appliance (S01); designating a tooth targeted for the insertion path setting (S02); setting the insertion path for the designated tooth in an arbitrary direction (S03); displaying, on the screen, undercuts of each tooth caused by the set insertion path (S04); calculating and storing depth values of the undercuts for each tooth (S05); and calculating and storing the total sum of undercut volumes for each tooth according to the insertion path (S06).

RADICALLY POLYMERISABLE COMPOUND AND COMPOSITION

Resumen de: WO2024227533A1

The invention relates to a radically polymerisable compound represented by a structure of formula 1: PG-Sp-PCA-Sp- OG (O) NH-K-NHC (O) O-Sp-PCA-Spn-PG (formula 1), wherein PG = in each case independently selected from a radically polymerisable group, R1 = selected from hydrogen, a C1-C8 alkyl group, an aryl group and an araliphatic group having C6-C8 carbon atoms, R2 = selected from hydrogen, a C1-C4 alkyl group; Sp = in each case independently of one another a spacer group selected from unbranched and branched alkylene with C1-C19 carbon atoms, which may additionally contain oxygen, sulfur and/or -OOC- in the carbon chain, or Sp is absent; PCA = in each case independently of one another a polycyclic group; K = an aliphatic acyclic, saturated or unsaturated unit having C1-C15 carbon atoms, an aliphatic cyclic, saturated or unsaturated unit having C3-C15 carbon atoms, or an aromatic or araliphatic unit having C6-C14 carbon atoms; n = 1 to 9. The invention also relates to a process for preparing such a compound, a radically polymerisable composition containing such a compound, the use thereof and a cured dental material.

SEMICRYSTALLINE SULFUR CONTAINING POLYMERS FOR ORTHODONTIC APPLICATIONS

Resumen de: US2025009476A1

The present disclosure provides polymeric materials comprising semicrystalline sulfur-containing polymers, methods and curable compositions for making the same, and orthodontic appliances made from said polymeric materials.

分解性ポリ乳酸ポリマーブレンドを含む方法及び組成物

Resumen de: US2023139077A1

Disclosed herein polylactide polymer blend compositions, and methods of making and using such compositions.

PROCESS FOR THE PRODUCTION OF CERAMIC AND GLASS-CERAMIC DENTAL RESTORATIONS

Resumen de: US20260060781A1

Method for producing an all-ceramic dental restoration with a one-piece core and a shell structure, in which a digital construction model of the dental restoration is constructed, the CAD data set obtained is then divided into at least two separate CAD partial data sets. One partial data set defines the contour of the core structure and a second partial data set defines the contour of the shell structure. A green body of the core structure is produced by the first CAD partial data set and a green body of the shell structure of the restoration is produced by the second CAD partial data set. The core and shell structure are then joined together in the green state. The green body is then subjected to heat treatment to remove the binder and the component is then sintered to obtain the finished dental restoration.

一种用于组织工程半月板支架的生长因子可控释放载体及其制备方法

Resumen de: CN121622998A

本发明属于半月板损伤修复材料技术领域，具体涉及一种用于组织工程半月板再生修复的生长因子可控释放载体及其制备方法。本发明公开了一种用于组织工程半月板再生修复的生长因子可控释放载体及其制备方法，提出壳‑芯结构同轴静电纺丝载体，具体为通过同轴静电纺丝在壳芯层负载不同的生长因子，并且通过壳芯层使用不同降解速率载体（芯层降解速率大于壳层）实现生长因子的时序性释放，随着时间推移实现空心纤维结构。将静电纺丝纤维打碎形成短棒状纤维与生物墨水结合，通过3D打印实现精确的异质性结构以及成分仿生。本申请通过微观尺度的降解速率调控与结构设计，突破时序释放与血管引导的技术瓶颈。

Scanning and printing calibration tool

Resumen de: JP2024160362A

To provide a dentition phantom model capable of precisely evaluating scanning accuracy of a scanner.SOLUTION: A dentition phantom model 100 includes a base layer composed of a first base layer 110 and a second base layer 120, and a dentition layer 130 disposed on the base layer and including a tooth model, where the tooth model is configured so that a shape observed from one direction is different respectively from shapes observed from the remaining other directions.SELECTED DRAWING: Figure 1aa

一种用于制作后巩膜加固术垫片材料的取材模板及其制作装置

Resumen de: CN223979895U

本实用新型公开了一种用于制作后巩膜加固术垫片材料的取材模板及其制作装置，立体状态时，取材模板包括由中间的第一加固区和两侧的第一连接带构成的垫片立体模板，平面状态时，包括由所述垫片立体模板展开形成平板式结构的垫片平面模板，垫片平面模板包括中间的第二加固区和两侧的第二连接带，第二加固区上端轮廓为若干弧线光滑过渡连接并向上凸起的曲线，第二加固区下端轮廓为若干弧线光滑过渡连接组成并向上凸起曲线；第二连接带轮廓为若干曲线光滑过渡连接组成的长条形。本实用新型中3D打印系统根据不同患者的实际情况，准确制造出适合每一位患者的垫片模板，再根据该垫片模板制出垫片，提高了手术的效率，而且提高了垫片精度，保证手术质量。

一种3D打印颌骨生物支架

Resumen de: CN121622995A

本发明提供了一种3D打印颌骨生物支架，利用3D打印技术成功构建了负载颌骨BMSCs与牙髓dECM生物支架，同步满足颌骨缺损修复对机械支撑强度、生物活性微环境、成骨仿生诱导特性及免疫调控能力的核心需求。

心电图机及心电图机的打印控制方法

Resumen de: CN121622054A

本申请实施例提供了一种心电图机及心电图机的打印控制方法，包括：打印机构，包括包含第一加热点和第二加热点在内的多个加热点；驱动机构，用于驱动目标纸张和打印机构相对移动；控制器，用于：根据第一心电波形数据控制打印机构在第一目标纸张打印至少部分以第一预定布局排布的第一心电图报告，第一加热点用以生成其中的第一基线；根据第二心电波形数据控制打印机构在第二目标纸张打印至少部分以第二预定布局排布的第二心电图报告，第二加热点用于以生成其中的第二基线；第一心电波形和第二心电波形分别位于第一预定布局和第二预定布局二者布局相同的区域，以显著减少部分加热点的加热次数，进而提升心电图机中打印功能模块的使用寿命。

一种三维水凝胶支架及其制备方法和骨修复应用

Resumen de: CN121623010A

本发明涉及医用生物材料技术领域，尤其涉及一种三维水凝胶支架及其制备方法和骨修复应用。所述三维水凝胶支架为通过若干水凝胶管搭建的层叠的、三维有序结构，每层包括平行间隔排列的多根水凝胶管，相邻两层的水凝胶管之间呈夹角，所述三维水凝胶支架的组分包括海藻酸钠；在三维水凝胶支架中，每根水凝胶管之间具有大孔，每根水凝胶管内部具有全连通微通道，每根水凝胶管的外表面和内表面都具有表面取向性纳米纤维结构。本发明的三维水凝胶支架能很好的应用于骨修复方面，并且本发明利用3D打印、不均匀的交联和拉伸干燥联合技术成功构建了三维水凝胶支架，制备工艺简单准确，易于操作，有利于工业推广和应用。

一种医疗设备

Resumen de: CN121622053A

本发明提供了一种医疗设备，涉及具有纸张打印功能的医疗设备领域，包括主机和纸仓；纸仓包括纸仓壳体和纸辊，纸仓壳体上设有纸张放置空间，纸辊转动装配在纸仓壳体上；主机包括主机壳体、打印模块和限位部件；主机壳体上设有纸仓安装腔，在纸仓完全装入纸仓安装腔后，纸仓安装腔具有对应于顶部仓口的顶侧和与顶侧相对的底侧；打印模块具有打印部，限位部件设置在纸仓安装腔的顶侧，限位部件包括凸起部位，凸起部位朝向纸张放置空间凸出以限制打印纸的活动空间，在垂直于纸仓底面的方向上，凸起部位相对于打印部更靠近纸仓的底面。本发明能够降低医疗设备在打印过程中卡纸问题发生的概率。

一种防移位锁定加压接骨板及其制备方法

Resumen de: CN121622217A

本发明公开了一种防移位锁定加压接骨板及其制备方法，属于医疗器械技术领域。所述接骨板包括：具有解剖曲度的主体；设置在主体骨干对应区的梯度多孔结构区域，其孔隙率自中轴向两侧梯度降低，以优化力学匹配、促进骨长入；沿板体排列的多功能复合孔组，每组包含一个锁定孔和一个带倾斜加压滑道的动态加压孔；以及设于板体两端的T形定位槽与遍布骨接触面的微观防滑纹理构成的防移位锚定结构，确保术中瞬时定位与术后抗微动稳定。其制备方法基于患者医学影像进行参数化设计与有限元优化，并采用选区激光熔化技术一体成型。本发明有效解决了传统接骨板应力遮挡、术后移位与骨整合不足的临床问题，显著提升了固定效果与愈合质量。

一种具有结肠靶向功能的淀粉-鱼油复合3D打印凝胶糖果及其制备方法

Resumen de: CN121621425A

本发明公开了一种具有结肠靶向功能的淀粉‑鱼油复合3D打印凝胶糖果及其制备方法。通过脉冲电场‑微波协同预处理技术优化淀粉分子结构，结合微射流纳米化与动态超高压均质实现鱼油在淀粉基质中的高效复合与稳态化包埋，再经喷雾冷冻‑真空冷冻干燥技术构建多孔微球载体。最后，将所得微球粉末与特定亲水胶体复配成打印墨水，通过超声多段式辅助3D打印技术精准成型。本发明所制备的凝胶糖果兼具优异的抗氧化性与抗消化特性其鱼油释放率与淀粉水解率低。该产品具有结肠靶向释放功能，在结肠中发挥良好的肠道菌群调节功能，体外发酵总短链脂肪酸含量高，并能显著提升双歧杆菌与乳酸杆菌的相对丰度。

一种基于丝素蛋白的生物3D智能响应支架及其制备方法和应用

Nº publicación: CN121622997A 10/03/2026

Solicitante:

广西璟炜生物技术有限公司

Resumen de: CN121622997A

本发明涉及生物支架技术领域，具体涉及一种基于丝素蛋白的生物3D智能响应支架及其制备方法和应用，本发明的生物3D智能响应支架采用定向纤维膜、多孔海绵层和界面层三层仿生梯度结构，模拟天然组织，分别提供力学引导、细胞栖息与生物活性界面，协同促进血管、神经、皮肤的高质量再生。本发明具有pH/酶/温度三重响应单元，能感知病变微环境并触发靶向释放，可解决了传统物理载药突释率高的问题，实现按需精准给药。本发明采用SF/HPMC凝胶进行3D打印，打印精度高，使得本发明孔隙率差异<2%，产品性能稳定，孔隙结构可以根据不同组织（如血管、神经、皮肤）的再生需求进行精确设计和定制。