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217
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Última actualización
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Resultados 125 a 150 de 217
Resumen de: CN119949946A
本发明涉及医学辅助工具的制作方法，尤其涉及一种肘内翻截骨并复位矫正的3D导板的制备方法。它包括建模、确认截骨面、制作截骨复位工具导板、制作截骨导板和制作定位导板。利用这些导板组可以主动提高截骨部位及截骨平面方向精确度，同时通过使用截骨导板定位导针，复位工具导板是复位标志和复位工具，使得截骨远、近端复位更加简单和精准，从而提高手术的精度和成功率，同时采用单纯外侧小切口，可减少手术创伤，减少手术后肘关节僵硬，利于患者术后快速康复和恢复肘关节功能。
Resumen de: CN119949595A
本发明涉及足部矫正技术领域，公开了一种用于拇外翻矫正的3D打印鞋垫及制作方法，该鞋垫包括鞋垫主体、第一弹性带、第二弹性带、第一连接部、第二连接部、第三连接部以及第四连接部，鞋垫主体上具有用于贴合拇指的凹陷结构，其中第一连接部与第三连接部连接后，第一弹性带能够对拇趾施加向内的作用力；第二连接部与第四连接部连接后，第二弹性带能够对第一跖骨施加向外的作用力，对拇趾和第一跖骨的角度均进行有效控制，改善拇趾外翻情况以及改善第一跖楔关节的过度灵活，改善足部结构，缓解拇外翻症状。
Resumen de: CN119950812A
本发明属于软组织修复领域，公开了一种细菌响应型静电直写复合补片及其制备方法，细菌响应型静电直写复合补片包括静电直写补片和细菌响应型抗菌层(由带有正电荷的细菌响应型高分子材料与带有负电荷的抗菌物质构成)；其制备方法为：将带负电的材料与可降解高聚物溶于溶剂中后再用静电直写3D打印机制备带负电的静电直写补片，再将带有正电荷的细菌响应型高分子材料和带有负电荷的抗菌物质溶解于溶剂中配制成溶液，最后分别将溶液喷涂在静电直写补片表面并干燥后交替形成细菌响应型高分子涂层与抗菌物质涂层，制得细菌响应型静电直写复合补片。本发明可在不同的修复阶段实现对抗感染和调节免疫反应的最佳平衡，提高了治疗效果并加速组织再生。
Resumen de: CN119950813A
本发明涉及一种3D打印生物墨水及其制备方法。生物墨水尤其用于载淋巴免疫细胞，生物墨水由可成型材料和温敏材料混合制得，可成型材料为甲基丙烯酰化透明质酸，温敏材料为明胶，该生物墨水包含2％(wt/vol)Gelatin和0.5％(wt/vol)HAMA。该墨水体系可负载淋巴免疫细胞进行生物3D打印，利用该墨水体系打印的结构具有可调力学性能、可调孔隙率、高生物相容性等优点，可支持将人源免疫细胞在体外构建成具有仿生空间结构和复杂微环境的功能性仿生免疫类器官，从而为高通量开发低免疫原性、更安全有效的天然全人源化抗体提供一个新的方法途径，也为检测疫苗和其它免疫治疗药物药效提供一个新的体外模型。
Resumen de: CN119950125A
本发明提供一种髋臼骨缺损的植入假体及制作方法，其中植入假体包括龙骨本体和镂空骨架，龙骨本体的一端设有与骨盆顶壁连接的连接部，且龙骨本体另一端设有曲面板，曲面板的上下两表面均低于连接部的上下两表面；曲面板沿其弧度方向的横截面尺寸自连接部端向远离连接部端逐渐增大，并在靠近龙骨本体另一端端面处收缩呈预设横截面，以适配髋臼的解剖形态；镂空骨架通过骨水泥连接在龙骨本体的另一端，并包裹覆盖所述曲面板；且镂空骨架还延伸出龙骨本体的另一端，用于与经耻骨支骨骨盆缺损假体连接；龙骨本体和镂空骨架均采用骨整合材料或骨生物相容性材料制成；本发明能够大幅提高髋臼骨缺损重建的稳定性，显著降低植入假体松动的风险。
Resumen de: US2025145962A1
Disclosed herein are compositions, systems, and methods relating to three-dimensional bioprinted tissue models, in particular liver tissue modes. Compositions, systems, and methods as described here provide for improved tissue models, thereby improving their utility for diagnostic, clinical, and research purposes. In certain aspects, tissue models as described herein exhibit gene expression profiles, enzymatic function, and enzyme/protein secretion comparable to in vivo organs.
Resumen de: US2025143844A1
Devices, methods, and systems for placing dental auxiliaries on teeth are provided. In some embodiments, for example, a dental auxiliary positioner for placing a dental auxiliary on a tooth includes: a registration element configured to receive a patient's tooth; and an auxiliary support coupled to the registration element and further coupled to an auxiliary, where the auxiliary support is configured to position the auxiliary against a surface of the tooth, and where the auxiliary support includes a frame extending at least partially around the auxiliary, one or more struts coupling the auxiliary to the frame, and a flexible bridge coupling the frame to the registration element, where the flexible bridge is configured to bend in one or more directions relative to the tooth to adjust the position of the auxiliary on the surface of the tooth.
Resumen de: US2025143845A1
A method for fabricating an oral appliance may include forming, using a 3D additive manufacturing process, a polymeric shell having a plurality of teeth engaging structures shaped to engage the teeth of the patient and forming, using the 3D additive manufacturing process, a force generating component coupled to the plurality of teeth engaging structures, the force generating component may be configured to generate a force in response to a stimulus in order to reposition one or more teeth of the patient. The polymeric shell, the plurality of teeth engaging structures, and the force generating component may include a sequentially polymerized plurality of layers directly fabricated together using the 3D additive manufacturing process.
Resumen de: US2025143842A1
A series of orthodontic aligners may be produced by a process including receiving a first position of at least one tooth of a patient for a first treatment stage of plurality of orthodontic treatment stages, determining a movement vector magnitude and direction for moving the at least one tooth from the first position towards a second position, analyzing a surface of the at least one tooth of the patient based on the determined movement vector, designing a first orthodontic aligner of the series of orthodontic aligners based on the analysis of the surface of the at least one tooth of the patient so that a physical orthodontic aligner, when in position on teeth of the patient at the first treatment stage, moves the at least one tooth from the first position towards the second position along the determined movement vector, and fabricating the physical orthodontic aligner.
Resumen de: US2025144387A1
A transdermal drug delivery (TDD) system is provided accelerating the TDD process through the combination of (1) a micropump, (2) microneedles, and (3) nanoencapsulation. A 3D printed shape memory alloy (SMA) triggered micropump combined with polymeric nanoparticles loaded with a drug can be pumped through integrated microneedles. An SMA spring wire is used to actuate a loaded pumping spring to drive an elastic membrane into a chamber. The system's performance characterized an average membrane speed of 0.28 m/s. The efficacy of the system showed an almost 100% improvement for the total percentage of deposited polymeric nanoparticles over that of the untreated solution. The rapid response and demonstrated efficacy can be aimed for transdermal insulin injection.
Resumen de: US2025143839A1
A method for manufacturing a prefabricated crown including classifying a plurality of prefabricated crowns by type and size by a first module (5) of the table system (1); classifying the plurality of prefabricated crowns by color and material by a second module (7) of the table system (1); tabulating the type, size, color and material data of the prefabricated crowns classified in the above steps (S100, S110) by a third module (9) of the table system (1), and assigning an identification code to each data; a fourth step (S130) of manufacturing the tabulated plurality of prefabricated crowns; and inputting the measured type, size, color and material data of patient's tooth into a fourth module (11) of the table system (1) to select a prefabricated crown corresponding thereto.
Resumen de: US2025143840A1
Orthodontic appliances including dental aligners for orthodontic treatment. A system for manufacturing an orthodontic appliance includes a mold having a base and projections. The base and the projections are made of a resin configured to react with a fluid, such as water. The system further includes a fluid bath configured to receive the mold. A method of manufacturing an appliance includes providing a mold including projections representing teeth. The mold is made of a resin. The method further includes deforming a worksheet over the projections and exposing the resin to a fluid. At least one material property of the resin changes. During or afterwards, the appliance is removed from the mold. Removing the appliance may include self-removal. During exposing, the change in property includes a change in volume of the mold. Exposing the resin to the fluid includes submerging the mold in the fluid. The fluid may be liquid water.
Resumen de: US2025144271A1
Procedure for obtaining an artificial corneal construct by 3D printing. The procedure comprises the following stages: i. providing a composition in the form of bioink comprising type I collagen or a mixture of type I, type V and/or type VI collagen at a concentration between 0.2 and 80 mg/ml, at a pH between 3.4 and 9 and where the composition optionally comprises proteoglycans of corneal origin selected from the group consisting of chondroitin sulfate, dermatan sulfate and keratan sulfate or any combination thereof at a concentration between 1 and 10 g/ml; ii. printing between 2 and 25 successive layers of the composition comprising the bioink from the previous stage by means of 3D printing, wherein the 3D printing is characterized by presenting an accumulated height of between 400 and 6000 μm and a variation in height per layer of at least ten times the thickness per layer of the desired artificial corneal construct, wherein the variation in height per layer is understood as the distance at which one layer is produced over the previous layer; and producing each layer to obtain collagen fibrils having a direction with an angle of 70° to 110° with respect to the direction of the collagen fibrils of the previous layer, keeping the bioink at a temperature that does not gel; iii. induce collagen gelation by incubating the layered product obtained from stage ii at 30-40° C.; and iv, induce the hardening, compaction and/or controlled dehydration of the layered product obtained
Resumen de: US2025143923A1
A medical implant is disclosed. The medical implant includes a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first end and the second end. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.
Resumen de: US2025144268A1
The present invention provides a biocompatible three-dimensional scaffold and a composition for reconstructing lost tissue comprising the same. The scaffold of the present invention provides a mechanical support for a tissue cavity due to its strong physical strength and, at the same time, efficiently induces quantitative restoration of irreversibly lost tissue because the internal space thereof may be filled with active ingredients for tissue regeneration. In addition, when the spherical scaffold of the present invention is used, it may be efficiently inserted into a tissue cavity having any shape, and may also be degraded at an appropriate time after the completion of regeneration, indicating that it is useful as a scaffold for human transplantation for restoring various adipose tissues, including breast tissue.
Resumen de: US2025143564A1
This disclosure relates to methods and devices for designing customized contact lenses, by initially making dynamic wavefront sensor measurements through a trial contact lens that is fitted on an eye, and then calculating a WaveFront Guided (WFG) correction to be applied to the trial contact lens that reduces the RMS level of aberrations as much as practically possible. The output of the wavefront correction program is a customized lathe file that the manufacturer can use to make customized contact lenses on a lathe. The method works best for soft contact lenses and scleral lenses.
Resumen de: WO2025091796A1
Provided in the present application is a method for generating a digital orthodontic appliance model having a caries prevention function. The method comprises: obtaining a morphological information sample for generating a digital orthodontic appliance model, and a silica gel component sample for the morphological information sample, wherein the silica gel component sample at least includes a fluoride component sample, the fluoride component sample comprises sample data acquired from fluoride, the fluoride is adsorbed in silica gel and is released onto the surfaces of teeth by means of the silica gel, and the silica gel component sample comprises sample data acquired from the silica gel; and generating the digital orthodontic appliance model on the basis of the morphological information sample and the silica gel component sample. Therefore, an orthodontic appliance generated by means of the digital orthodontic appliance model is more suitable for a patient, and meets the personalized requirements of the patient. In addition, by means of providing the fluoride in the silica gel component sample, the orthodontic appliance is accurately and efficiently designed, and the fluoride can be released onto the surfaces of teeth by means of saliva in an oral cavity, thereby achieving the effect of preventing caries.
Resumen de: KR20250061095A
본 발명의 일실시예는 히알루론산 메타크릴레이트 및 PDRN을 포함하는 바이오 잉크를 제공한다. 본 발명의 실시예에 따른 바이오 잉크는, 종래의 HAMA를 사용한 하이드로젤 소재에 비해 신축성이 향상되어 좋은 물성을 가지는 특징이 있으며, 우수한 생체 적합성, 생체 치유능력을 지녀 다양한 분야에서 사용될 수 있는 우수한 성능의 소재를 제공한다.
Resumen de: KR20250062334A
본 발명은 생리학적으로 유사한 형태의 인공 폐 조직이 담지되어 있는 여러 개의 세포배양용 틀을 하나의 미세 유체칩에 연결한 후 하나의 유체 펌프로부터 모든 조직으로 일정한 양의 배양액을 흘려 폐 조직을 배양하기 위한 미세유체 칩 시스템 및 그 제조 방법에 관한 것이다. 이에 따른 본 발명은, 상부는 열린 공간(110)을 갖고, 하부는 다공질막(120)으로 이루어지며, 상기 다공질막(120)의 상부로 인공 폐 조직(10)을 3D 바이오 프린팅하여 형성한 세포배양용 틀(100); 상기 세포배양용 틀(100)이 삽입되는 삽입구멍(211), 상기 삽입구멍(211) 측으로 배양액을 흐르게 하는 미세관(212)이 형성된 미세유체 칩(200)을 포함하여 구성된다.
Resumen de: WO2025095908A1
This invention provides water-soluble, biocompatible, biodegradable, 3D-printable, and radiation-curable polymeric bioinks for tissue engineering and a variety of other biomedical applications. Synthesized using tailor-designed polyurethane and polyurea oligomers with controlled molecular weights and compositions, these bioinks offer optimized viscosity profiles for 3D printing and enhanced mechanical properties and structural stability. They are applicable in tissue engineering, wound healing, drug discovery, and other biomedical fields.
Resumen de: WO2025095516A1
The present invention relates to a method for optimizing percutaneous pulmonary artery valve insertion by using a patient-specific model and in vitro simulation circulation through 3D printing, to find an optimal percutaneous pulmonary artery valve size and an optimal insertion position in order to increase a success rate of the percutaneous pulmonary artery valve insertion. In this regard, the present invention includes the steps of: obtaining a computed tomography (CT) image by performing CT on a heart; generating a 3D printing file format after performing 3D modeling by subdividing the heart and blood vessels on the basis of the CT image; and manufacturing an outflow path model (10) corresponding to an outflow path of the right ventricle of a person to be photographed by performing 3D printing using the 3D printing file.
Resumen de: WO2025095385A1
The present invention relates to a porous three-dimensional meniscus scaffold and a biodegradable medical device comprising same. According to the present invention, external force applied to the meniscus scaffold can be more reliably and evenly dispersed by appropriately adjusting a ratio of intervals between fibers inside the meniscus scaffold, and thus the biodegradable medical device comprising the meniscus scaffold has greater structural stability.
Resumen de: WO2025095190A1
The present invention relates to a method for manufacturing an osteoinductive scaffold having excellent osteoconductivity and osteoinductivity by using a 3D printing technology. According to the present invention, it is possible to provide an osteoinductive scaffold having improved biocompatibility, cell adhesion, cell proliferation ability, osteoconductivity, and osteoinductivity through a frame part formed of a mixture of a biodegradable polymer and an allogeneic bone-derived osteoinductive material having a lattice pattern and an osteoinductive part formed of an allogeneic bone-derived osteoinductive material.
Resumen de: US2025145942A1
Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.
Nº publicación: WO2025097054A1 08/05/2025
Solicitante:
ALIGN TECH INC [US]
ALIGN TECHNOLOGY, INC
Resumen de: WO2025097054A1
Devices, methods, and systems for placing dental auxiliaries on teeth are provided. In some embodiments, for example, a dental auxiliary positioner for placing a dental auxiliary on a tooth includes: a registration element configured to receive a patient's tooth; and an auxiliary support coupled to the registration element and further coupled to an auxiliary, where the auxiliary support is configured to position the auxiliary against a surface of the tooth, and where the auxiliary support includes a frame extending at least partially around the auxiliary, one or more struts coupling the auxiliary to the frame, and a flexible bridge coupling the frame to the registration element, where the flexible bridge is configured to bend in one or more directions relative to the tooth to adjust the position of the auxiliary on the surface of the tooth.
BOPI
Sede Electrónica
