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PREFABRICATED CROWN FOR DENTAL PROSTHETIC RESTORATION AND METHOD FOR MANUFACTURING SAME

Resumen de: US2025143839A1

A method for manufacturing a prefabricated crown including classifying a plurality of prefabricated crowns by type and size by a first module (5) of the table system (1); classifying the plurality of prefabricated crowns by color and material by a second module (7) of the table system (1); tabulating the type, size, color and material data of the prefabricated crowns classified in the above steps (S100, S110) by a third module (9) of the table system (1), and assigning an identification code to each data; a fourth step (S130) of manufacturing the tabulated plurality of prefabricated crowns; and inputting the measured type, size, color and material data of patient's tooth into a fourth module (11) of the table system (1) to select a prefabricated crown corresponding thereto.

ORTHODONTIC APPLIANCES, SYSTEMS FOR MANUFACTURING ORTHODONTIC APPLIANCES, AND METHODS OF MANUFACTURING ORTHODONTIC APPLIANCES UTILIZING THOSE SYSTEMS

Resumen de: US2025143840A1

Orthodontic appliances including dental aligners for orthodontic treatment. A system for manufacturing an orthodontic appliance includes a mold having a base and projections. The base and the projections are made of a resin configured to react with a fluid, such as water. The system further includes a fluid bath configured to receive the mold. A method of manufacturing an appliance includes providing a mold including projections representing teeth. The mold is made of a resin. The method further includes deforming a worksheet over the projections and exposing the resin to a fluid. At least one material property of the resin changes. During or afterwards, the appliance is removed from the mold. Removing the appliance may include self-removal. During exposing, the change in property includes a change in volume of the mold. Exposing the resin to the fluid includes submerging the mold in the fluid. The fluid may be liquid water.

ARTIFICIAL CONSTRUCTS FOR USE IN OPHTHALMOLOGY, METHODS FOR OBTAINING THE SAME, AND THEIR USE

Resumen de: US2025144271A1

Procedure for obtaining an artificial corneal construct by 3D printing. The procedure comprises the following stages: i. providing a composition in the form of bioink comprising type I collagen or a mixture of type I, type V and/or type VI collagen at a concentration between 0.2 and 80 mg/ml, at a pH between 3.4 and 9 and where the composition optionally comprises proteoglycans of corneal origin selected from the group consisting of chondroitin sulfate, dermatan sulfate and keratan sulfate or any combination thereof at a concentration between 1 and 10 g/ml; ii. printing between 2 and 25 successive layers of the composition comprising the bioink from the previous stage by means of 3D printing, wherein the 3D printing is characterized by presenting an accumulated height of between 400 and 6000 μm and a variation in height per layer of at least ten times the thickness per layer of the desired artificial corneal construct, wherein the variation in height per layer is understood as the distance at which one layer is produced over the previous layer; and producing each layer to obtain collagen fibrils having a direction with an angle of 70° to 110° with respect to the direction of the collagen fibrils of the previous layer, keeping the bioink at a temperature that does not gel; iii. induce collagen gelation by incubating the layered product obtained from stage ii at 30-40° C.; and iv, induce the hardening, compaction and/or controlled dehydration of the layered product obtained

MEDICAL IMPLANT

Resumen de: US2025143923A1

A medical implant is disclosed. The medical implant includes a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first end and the second end. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

METHODS AND DEVICES FOR IMPROVED EEG SOURCE IMAGING AND IMPROVED ELECTROSTIMULATION OF THE BRAIN

Resumen de: EP4548847A1

Several methods and devices are proposed for improved electroencephalography source imaging (ESI) and/or improved and tailored electrostimulation. The approach is based on an electrode helmet (1) that carries a set of electrodes (2) at precisely known and predefined spatial positions, in particular because each electrode (2) is held in place by a respective electrode holder (4) of the helmet (1). As the helmet (1), in particular said electrode holders (4), can be 3D-printed based on 3D design data which are based on patient-specific 3D anatomical data, the helmet (1) offers a platform for patient-specific recording of EEG signals and/or electrostimulation. Accordingly, tedious 3D optical scanning of each electrode (2) position is no longer necessary, such that highly accurate ESI and electrostimulation are possible as soon as the patient is wearing the helmet (1) in the intended well-defined orientation on his head (cf. Figure 2).

PHOTOCROSSLINKABLE RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Resumen de: WO2024002806A1

Recombinant bacterial collagen-like protein with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 characterized in that the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1 and that the recombinant collagen-like protein is functionalized with ethylenic unsaturated groups.

3D PRINTING TRANSPARENT BIOINK FORMULATION

Resumen de: WO2024003287A1

Bioink comprising modified fibers of MFC with a diameter of about 100-400 nm.

3D HYDROGEL COMPOSITION FOR 3D PRINTING AND METHOD OF MANUFACTURING ARTIFICIAL BLOOD VESSEL USING THE SAME

Resumen de: KR20250060126A

본 발명은 과립형 하이드로겔 및 매트릭스 하이드로겔 용액을 포함하고, 상기 매트릭스 하이드로겔 용액은 아크릴아미드계 화합물, 적어도 2 이상의 히드록시기를 포함하는 화합물, 가교제, 개시제 및 용매를 포함하는 것인 3D 프린팅용 하이드로겔 조성물 및 이를 이용한 인공 혈관의 제조방법에 관한 것이다.

/ LIGHT/ELECTRICALLY SENSITIVE SMART BIO INK AND METHOD OF MANUFACTURING SAME

Resumen de: KR20250060737A

본 발명의 일실시예는 광경화성 바이오 잉크; 도파민 소중합체; 맥신; 및 광 개시제를 포함하는 광/전기 감응성 바이오 잉크를 제공한다. 본 발명의 실시예에 따른 광/전기 감응성 바이오 잉크에 의해 제조된 하이드로젤 소재는, 종래의 하이드로젤 소재에 비해 압축 강도, 인장 강도, 인장 정도가 향상되어 높은 물성 및 우수한 생체 적합성을 지니며 광열 효과 및 전기 전도성을 가지는 스마트 3D 프린팅 소재를 제공한다.

MEDICAL TISSUE WRAP

Resumen de: AU2023370241A1

The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

3D METHOD FOR MANUFACURING TEMPORARY TEETH USING 3D PRINTING AND APPARATUS THEREOF

Resumen de: KR20250060517A

본 발명은 3D 프린팅을 이용한 임시 치아의 제조 방법 및 그 장치에 관한 것으로서, 상기 방법은, 혼합 용기에 아크릴레이트 계열의 레진, 광개시제, 분산제 및 착색제를 혼합하여 베이스 레진을 생성하는 단계; 강화제를 상기 베이스 레진에 첨가하여 광경화성 수지 조성물을 생성하는 단계; 및 3D 프린팅을 이용한 상기 광경화성 수지 조성물의 성형 과정을 통해 임시 치아를 가공하는 단계;를 포함하되, 상기 강화제는, 이트리아 안정화 지르코니아(YSZ; yttria-stabilized zirconia) 또는 카본 나노튜브(CNT; carbon nanotube) 중 적어도 어느 하나를 포함하는 것이다.

一种3D打印的微针贴片及其制备方法和应用

Resumen de: CN119925310A

本发明涉及一种3D打印的微针贴片及其制备方法和应用，所述制备方法包括以下步骤：(1)将明胶溶液与甲基丙烯酸酐混合，透析，冷冻干燥，获得甲基丙烯酸化明胶；(2)将药物溶液与甲基丙烯酸化明胶混合，3D打印成型。本发明提供了一种无创、便捷的给药方式，微针贴片针尖具有较强穿刺力，同时可以有效减少穿刺时的痛感，并提高药物传递的精准性。

制造牙齿替代品部件的方法、适配器、坯件以及由适配器和坯件组成的套件、由多个适配器组成的套件

Resumen de: WO2024126460A1

A method for producing a dental restoration part (200), in particular a fixed dental restoration part (200), that can be connected to a tooth stump (110), wherein an adapter (10) for a machine tool and a blank (50) for the dental restoration part (200) is produced.

一种用于光固化增材制造的光敏树脂及其制备的陶瓷浆料

Resumen de: CN119930936A

本发明公开了一种用于光固化增材制造的光敏树脂及其制备的陶瓷浆料，按重量份计，其组成为：预聚物7份~50份，单官能度单体3份~100份，低官能度单体30份~95份，高官能度单体0.5份~50份，分散剂0.4份~10份，光引发剂0.01份~5份，塑化剂2份~20份，光吸收剂0.01份~0.11份和/或阻聚剂0.01份~1.5份；其中预聚物占光敏树脂总重量的15%以上。本发明光敏树脂粘度低，同时使制备的浆料具有低粘度特性，且打印件具有光滑表面；能够抑制X/Y平面过曝，提高光固化精度；能有效解决打印生坯变形问题，及有机物分解排除引发的开裂等问题，陶瓷生坯密度高，可打印薄壁结构。

一种基于3D打印导板的腰椎置钉导航定位系统及方法

Resumen de: CN119924980A

本发明提供一种基于3D打印导板的腰椎置钉导航定位系统及方法，涉及医疗手术导航技术领域，包括：获取腰椎图像；对腰椎图像进行预处理；构建基于卷积神经网络的椎体识别模型；将预处理后的腰椎图像输入至椎体识别模型进行椎体识别，确定腰椎图像中每个椎体的类别以及形状；通过3D打印技术，设计与腰椎图像中各个类别的椎体的形状对应的3D打印导板；获取手术过程中3D打印导板图像；对3D打印导板图像进行预处理；构建基于卷积神经网络的导孔识别模型；将预处理后的3D打印导板图像输入至导孔识别模型进行导孔识别，确定3D打印导板上的各个导孔的位置；根据3D打印导板中的各个导孔的位置，进行腰椎置钉手术的导航定位。

用于3D打印的图层图像提供方法及用于实现其的装置

Resumen de: WO2024076024A1

A method performed by a computing system, according to one embodiment of the present disclosure, comprises the steps of: determining a masking area of a current layer on the basis of a non-overlapping area between the current layer and at least one previous layer from among a plurality of layers; and updating an image of the current layer in accordance with a user input for setting a light exposure amount with respect to the masking area of the current layer, wherein the plurality of layers are designed to sequentially cure a photocurable material in each layer unit for 3D printing.

一种生物钛合金-羟基磷灰石梯度复合材料及其喷射成形方法

Resumen de: CN119927228A

本发明公开了一种生物钛合金‑羟基磷灰石梯度复合材料及其喷射成形方法，所述生物钛合金‑羟基磷灰石梯度复合材料由合金相和陶瓷相组成，所述合金相为β型钛合金，所述陶瓷相为羟基磷灰石，所述生物钛合金‑羟基磷灰石梯度复合材料具有三维梯度结构，集合了β型钛合金与自然骨更匹配的力学性能、良好的抗蚀耐磨性及生物相容性等特点，和羟基磷灰石良好的生物活性和骨传导性等特点。本发明提供的喷射成形方法包括粉末浆料制备、浆料喷射成形、成形坯的脱脂和烧结等步骤，喷射成形方法实现了β型钛合金‑羟基磷灰石复合材料的三维梯度结构，并可实现个性化且高精度制造梯度复合材料骨修复植入体。

一种特殊晶格结构的腕部3D打印康复支具及其制备方法

Resumen de: CN119925059A

本发明公开了一种特殊晶格结构的腕部3D打印康复支具及其制备方法，属于医疗康复支具技术领域，包括通过3D打印技术制备的腕部支具、指部支具以及指套，腕部支具、指部支具和指套之间可拆卸连接，腕部支具和指部支具的内部均设置有充气囊，腕部支具和指部支具的连接件具体为可向两者内部充气囊进行充气的紧固卡扣，本发明支具具备蜂窝状、网格状或梯形支撑结构，通过计算机辅助设计（CAD）与优化算法，实现支具在保证强度的前提下大幅减轻重量，支具表面设有多个透气孔，结合拓扑结构本身的网格特性，确保良好的通气性能，避免长时间佩戴时产生闷热和不适，且可根据康复进程调整不同区域的支撑强度，便于拆装和清洁。

一种高精度数字化全口义齿3D打印方法

Resumen de: CN119925017A

本发明涉及义齿制作技术领域，且公开了一种高精度数字化全口义齿3D打印方法，包括以下步骤：得到目标对象的初始义齿模型；获取咬合点调整数据；获取实际调整数据；基于实际调整数据对初始义齿模型进行调整，并转换为3D打印指令后进行3D打印；有利于通过利用有限元分析模拟咬合时应力分布，获取三维咬合热力图，并输入至构建好的CNN网络模型中，获取咬合点调整数据，并将有效咬合接触点的调整数据映射至实体模型中，获取实际调整数据；通过扫描仪获取患者口腔三维数据，并结合神经网络模型进行数字化分析，提高义齿制作精度，并采用3D打印方式进行制作，制作效率高、患者佩戴舒适感和咬合好，及时解决种植患者的饮食困难问题。

由用于准备人的咬合平面的迁移、特别是永久迁移的装置组成的套件及相关方法

Resumen de: WO2023222192A1

The invention relates to a series (100) comprising devices for assisting in the displacement of the occlusal plane of a person (P), said series comprising at least two devices (10), the devices (10) each comprising at least one jaw device (11, 12), the at least one jaw device (11, 12) comprising an upper jaw device (11) and/or a lower jaw device (12), and the devices (10) being designed to be worn by the person (P) according to a predefined order. In at least one device (10.1, 10.2), the at least one jaw device (11, 12) has at least one height element on a first side. At least two contact regions, preferably local contact regions, are formed on the at least one height element at different positions of molar elements. At least one additional contact region, in particular an additional local contact region, is formed on a second side of the at least one jaw device (11, 12). The at least three contact regions define the plane (GE), wherein the plane (GE) differs from a starting occlusal plane of the person (P) or from a current occlusal plane of the person (P) with respect its inclination, modified by the at least one height element, in a frontal section or sagittal section and/or with respect to its height position modified by the at least one height element, and wherein, in at least one other device of the series (100), a different inclination in a frontal section or sagittal section and/or a different height position of the plane is adjusted by at least one additional height

一种基于3D打印的具有中药穴位刺激的脊柱侧凸矫形装置

Resumen de: CN222828712U

本实用新型公开了一种基于3D打印的具有中药穴位刺激的脊柱侧凸矫形装置，属于医疗器械技术领域。它包括矫形器本体和刺激器，矫形器本体根据患者脊柱侧凸的外形结构、中医所选取的脊柱侧凸处的穴位位置以及功能影像数据经3D打印而成，刺激器根据中医具体脊柱侧凸严重程度以及相对舒适度经3D打印而成，刺激器通过魔术贴安装在矫形器本体上，刺激器的内部设有储药腔，储药腔内设置有药物，刺激器的一端部设有透药孔，储药腔与透药孔相连通。本实用新型中利用3D打印技术所制作的矫形器本体，能够与由3D打印技术所打印的带有透药孔的刺激器搭配使用，改善现有矫形器仅仅矫形的作用，提高矫正效果和患者的舒适感。

基于框架结构支架的组织工程一体化气管再生构建方法及应用

Resumen de: CN119925691A

本发明公开了基于框架结构支架的组织工程一体化气管再生构建方法及应用。基于3D打印生物弹性体框架结构支架构建多组织结构一体化气管，高度模拟天然气管的复杂结构和生理功能。首先利用温敏水凝胶Pluronic F‑127在37℃下成半固态凝胶，4℃低温下液化的特性，采用温敏水凝胶占位后牺牲的策略，实现了软骨细胞和成纤维细胞在二维平面上图案化分布。其次通过2D到3D的卷合组装策略，模拟三维管状气管结构，并在裸鼠皮下实现C形软骨环/O形纤维环交替分布式及轴向条状纤维束三重结构的有序再生。最后成功提取气道黏膜上皮并在体外分离扩增出足量的气道基底细胞，利用光交联水凝胶将其负载到再生气管内壁，实现气道上皮功能仿生，增强生理功能性。

一种适用于光固化增材制造的氧化锆陶瓷材料及制备修复体的方法

Resumen de: CN119925175A

本发明公开了一种适用于光固化增材制造的氧化锆陶瓷材料及制备修复体的方法，其原料由纳米氧化锆粉体和光敏树脂混合液组成，其中纳米氧化锆粉体的含量在79wt％以上；所述纳米氧化锆粉体的粒径在10‑400纳米。本发明烧结后能够制备出0.1mm厚度的超薄修复体以及至少3个单位的桥体不开裂，烧结后陶瓷件层间力学差异较小，修复体整体精度高，满足单个修复体整体误差≤120um的应用要求。

一种可通过神经调控促进心肌梗死后心肌组织修复的预神经化细胞补片及其制备方法和应用

Resumen de: CN119925711A

本发明涉及一种可通过神经调控促进心肌梗死后心肌结构修复和心功能重建的预神经化细胞补片及其制备方法和应用，属于生物技术领域。所述可通过神经调控促进心肌梗死后心肌组织修复的预神经化细胞补片是由包含水凝胶基质、无机生物活性材料和神经相关细胞的生物墨水经过生物3D打印得到的三维支架结构细胞补片经过交联和预神经化培养得到的生物复合支架材料。本发明所述细胞补片是一种三维的生物复合支架材料，具有优异的神经活性，能够利用神经元高效地促进心肌梗死后的心肌组织修复及心脏功能重建。

一种光固化组合物、导电柔性膜层及柔性压力传感器

Nº publicación: CN119931243A 06/05/2025

Solicitante:

中国科学院宁波材料技术与工程研究所浙江工研院发展有限公司

Resumen de: CN119931243A

本发明提供了一种光固化组合物、导电柔性膜层及柔性压力传感器，将包括柔性光敏树脂、光引发剂和修饰改性的碳纳米管的光固化组合物，利用3D打印技术制备得到的导电柔性膜层以及柔性压力传感器。本发明的导电柔性膜层即使在经历大幅度弯曲后，仍能维持其导电性能，本发明制备的柔性压力传感器中，压力传感器阵列中每个传感单元对小于1kPa的轻微载荷以及超过150kPa的载荷均有显著响应。这表明本发明的柔性压力传感器具有较宽的压力检测范围，在柔性电子、智能穿戴设备、医疗健康监测等领域具有广泛的应用前景。