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液滴生成装置、インクジェット装置、及び薬液デリバリー装置

Resumen de: JP2025093255A

【課題】従来よりも高いエネルギー密度で液体から液滴を生成することができ、また、構成部品の損傷を防止することもできる液滴生成装置、インクジェット装置、及び薬液デリバリー装置を提供すること。【解決手段】液滴生成装置１００は、全反射面６Ａで入射レーザ光ＬＳＲ１を全反射させることにより全反射面６Ａから液体２に染み出すエバネッセント光ＥＶＬを、導電性ナノ粒子７に照射する。これにより、液滴生成装置１００は、エバネッセント光ＥＶＬによって導電性ナノ粒子７でプラズモン共鳴を励起させ、全反射面６Ａから離れた位置で電界強度を増強させることにより液体２にエネルギーを与え、液体２を液滴化させる。【選択図】図１

一种用于将药物精准递送至圆窗龛的个性化辅助植入物

Resumen de: CN120168221A

本发明公开了一种用于将药物精准递送至圆窗龛的个性化辅助植入物，包括设置于外耳道的主结构；所述主结构的一个底面位于骨性外耳道中部，朝向鼓膜及中耳，另一个底面位于外耳道开口；所述主结构的侧面的形状轮廓与患者外耳道的解剖结构相适配并机械性固定连接；所述主结构的两个底面之间设有中空的直线的输送通道，且所述输送通道的延长线对准内耳结构的圆窗龛；所述主结构采用生物相容性柔性材料制造。本发明能够避免传统的内窥镜引导下经鼓膜注射给药依赖医生手动操作，存在个体操作差异、解剖复杂性影响以及药物流失风险的问题，并且能够广泛应用于药物输送、造影剂及局部麻醉剂注射、基因治疗、生物传感器或微电极植入等领域。

一种3D打印钛合金复合涂层材料及其制备方法和应用

Resumen de: CN120174451A

本发明公开了一种3D打印钛合金复合涂层材料及其制备方法和应用，涉及钛合金材料技术领域。通过在3D打印钛合金基体上形成微弧氧化陶瓷涂层并原位生长Mn‑MOF材料，能够显著提高钛合金的生物相容性，该复合涂层不仅提高了3D打印钛合金基体的表面粗糙度，而且通过Mn的引入有效促进了细胞增殖和粘附，从而提高了钛合金在生物医用领域的应用潜力。

一种墨水直写3D打印陶瓷材料及其制备方法和应用

Resumen de: CN120168711A

本发明公开了一种墨水直写3D打印陶瓷材料及其制备方法和应用。所述制备方法包括步骤：制备得到氧化锆陶瓷浆料，所述氧化锆陶瓷浆料为粘弹性浆料，在剪切速率>10s‑1时，黏度＜100Pa·s，且浆料的屈服应力＞200Pa；按照预定的程序结构将所述氧化锆陶瓷浆料进行墨水直写3D打印，实现原位实时固化，得到三维陶瓷结构前体；将所述三维陶瓷结构前体进行烧结。本发明的制备方法通过优化氧化锆陶瓷浆料参数，经过墨水直写3D打印后，出料均匀，粘结强度好，烧结变形小，收缩率稳定，利于控制孔隙率，适用于打印不同填充比的陶瓷材料，便于模拟天然牙齿弹性模量梯度变化，得到更符合牙齿实际弹性模量分布的桩核修复系统。

在处理患者口腔中的牙齿状况的方法中使用的可固化组合物

Resumen de: WO2024110805A1

The invention relates to a curable composition for use in a process of treating a dental situation in the mouth of a patient, the curable composition comprising radiation-curable component(s), photo-initiator(s), the photo-initiator(s) exhibiting an absorption in the UV light region, and an absorption in the visible light region, the absorption in the UV light region being stronger than the absorption in the visible light region, optionally filler(s), optionally additive(s), the process comprising the steps of additive manufacturing a dental or orthodontic article layer-by-layer using radiation with a wavelength in the UV light region, attaching the dental or orthodontic article to a surface of hard dental tissue or a dental material, applying radiation with a wavelength in the visible light region to the dental or orthodontic article.

用于骨移植的具有管腔的装置

Resumen de: AU2023371660A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body with a proximal end and a distal tip, housing a scaffold with a porous structure distributed in proximal and distal lattices. The device includes an upper lumen in fluid communication with a first opening at the proximal end, and a lower lumen in fluid communication with a second opening at the proximal end. The device is configured to support independent delivery of cement and cells to the lattices. In some embodiments, the device is a bone screw with a thickened head-neck junction, designed to reduce the likelihood of rod breakage during installation. The methods involve implanting the device into a patient's bone, providing an innovative approach to fracture treatment.

一种多孔结构钽金属牙种植体及其加工方法

Resumen de: CN120168160A

本发明公开了一种多孔结构钽金属牙种植体及其加工方法，属于牙科口腔技术领域；包括包括纯钛实体部分和钽小梁部分；所述纯钛实体部分上设有自攻型螺纹；所述钽小梁部分为螺旋状结构；沿纯钛实体部分的自攻型螺纹设有用于嵌入钽小梁的螺旋槽；钽小梁部分位于对应的螺旋槽。本发明整体均匀的增加骨结合效果，减少骨结合时间，提高稳定性。

一种弹性模量梯度桩核材料及其制备方法、弹性模量梯度桩核

Resumen de: CN120168151A

本发明公开了一种弹性模量梯度桩核材料及其制备方法，和采用该材料制备得到的弹性模量梯度桩核。本发明的制备方法首先通过临床扫描患者桩道形态，制备出形态大小匹配的桩核修复系统，进而通过模拟天然牙齿的弹性模量梯度分布，利用增材制造工艺制备出具有仿生功能梯度桩核系统，可以改善桩、桩‑牙齿界面及牙齿部位的应力分布情况，有利于延长桩核修复患牙的寿命。

支具建模方法、设备、介质及支具制作方法

Resumen de: WO2024045916A1

The present application relates to the technical field of brace design, and relates to a brace modeling method, a device, a medium, and a brace manufacturing method. The brace modeling method comprises: obtaining a three-dimensional model of a target part of a limb; determining feature mark points of the three-dimensional model; determining brace modeling parameters of the three-dimensional model according to the feature mark points; and on the basis of the brace modeling parameters, generating brace file information corresponding to the target part, so that a brace can be manufactured later by using the brace file information. Thus, the convenience and accuracy of brace modeling can be improved, the personalized requirements of brace design are met, and the matching degree between the obtained brace model and the limb of a patient can be improved. Moreover, the problems due to the fact that brace file information designed by the existing automatic generation design processes can only be used for simple model processing and cannot be practically applied to complex brace design are solved, the design time of brace manufacturing can be effectively shortened, and the brace design costs can be reduced.

BIODEGRADABLE 3D PRINTED STRUCTURE FOR BONE AUGMENTATION

Resumen de: WO2025120338A1

Biodegradable 3D printed structure for bone augmentation (1) comprises an outer structure (100) and an inner structure (200) that are printed from polylactide (PLA), wherein the inner structure (200) is filled with a chitosan and hydroxyapatite gel and the outer structure (100) is coated with a chitosan and hydroxyapatite composite. The outer structure (100) has a tunnel-like shape resembling an elongated projection of the letter "U" rotated 180 degrees in depth. Implants made in the form of a biodegradable 3D-printed structure for bone augmentation as disclosed in the present invention can be adapted to each individual patient and each individual situation, which will optimize the dentist's time required for the procedure and treatment, and will also facilitate the recovery of the patient due to the reduction of the invasiveness of the procedure. This makes the entire procedure faster, simpler, and painless, but also financially acceptable for patients.

一种晶状体固定标记器及其制作方法、设备

Resumen de: CN120168219A

本发明提供了一种晶状体固定标记器及其制作方法、设备，晶状体固定标记器包括手柄和与手柄连接的固定基座，手柄与固定基座通过错位方式连接，固定基座在远离手柄的一侧开设有凹口，凹口的两侧均设有用于标记晶状体角膜缘特定位置的凸起部，且凹口的两侧间设有具有呈弧形的平滑凹面，且设置于凹口的同一侧上的各凸起部位于同一直线上。本发明提出的方案通过将手柄与基座错位设置，有助于用户观察固定状况和标记位置，增加了手术操作的精准性，提高手术的成功率，凸起部能够能够精确标记晶状体角膜缘的多个特定位置，弧形的平滑凹面设计有助于引导晶状体的位置，能够减少与眼部的摩擦，避免损伤角膜或晶状体，提高手术的安全性和舒适性。

一种3D打印构建菌丝体活体材料并调控生长行为的方法

Resumen de: CN120173754A

本申请公开了一种3D打印构建菌丝体活体材料并调控生长行为的方法，通过制备封装了真菌孢子的微凝胶颗粒，形成具有优异流变性能的双相微凝胶生物墨水；该墨水适用于挤出式3D打印，可支持真菌孢子的萌芽和菌丝网络的生长，实现菌丝体自生长行为在空间约束、营养浓度和基质刚度等关键因素上的精准调控。本申请通过设计构建自引导菌丝体生长通道结构，为工程化活体材料的设计与应用提供了创新解决方案，具有广阔的应用前景。

一种3D打印丝素蛋白基温敏水凝胶及其制备方法与应用

Resumen de: CN120173185A

本发明涉及一种3D打印丝素蛋白基温敏水凝胶及其制备方法与应用，属于水凝胶技术领域。本发明的制备方法包括以下步骤：S1、向溴化锂溶液中加入丝素蛋白和甲基丙烯酸缩水甘油酯进行交联反应，经透析、离心、冷冻干燥得到改性丝素蛋白；S2、将改性丝素蛋白、异丙基丙烯酰胺、光引发剂、阻光剂和水混合均匀，经离心脱泡得到光固化生物墨水；S3、通过DLP 3D打印技术，将光固化生物墨水制成3D打印丝素蛋白基温敏水凝胶。该3D打印丝素蛋白基温敏水凝胶可以实现药物负载，获得具有精确可控多孔结构的水凝胶并实现药物的可控释放。

一种压阻传感器阵列及其制备方法

Resumen de: CN120176914A

本发明提供一种压阻传感器阵列及其制备方法，属于柔性传感器技术领域，与现有技术相比，本发明具有器件可拉伸特性，压阻传感器具有抗应变干扰稳定性。采用光固化3D打印技术，制备出软硬结合的基底结构，使压阻传感器阵列具备本征可拉伸性，有助于适应复杂形变环境；通过设计负泊松比岛桥结构，显著提升了器件的整体拉伸性能，确保其在大应变下的可靠性；结合PU/MXene敏感材料和传感层微观圆锥结构的优化设计，大幅提高了传感器在压力加载时的电信号灵敏度，实现了更精确的力学响应；同时，利用3D打印技术制备的传感器阵列相比传统制备方法更加高效，工艺流程简单且易于规模化生产，具有显著的优势。

3D Strontium-releasing hierarchically structured 3D-printed scaffolds for promoting osteochondrial regeneration and manufacturing method thereof

Resumen de: WO2025127798A1

The present invention relates to a strontium-emitting 3D printing scaffold for promoting bone cartilage regeneration and a method for manufacturing same. The scaffold continuously maintains the emission of a triad of ions including strontium (Sr), silicate (Si), and calcium (Ca) to promote cell migration to a damaged site, and has a hierarchical porous structure, and thus enhances tissue regeneration by increasing cell engraftment, immune regulation, and angiogenesis, and exhibits an excellent anti-inflammatory effect. Therefore, the scaffold can be effectively used for the regeneration of damaged bone and cartilage tissue.

PROSTHESIS FOR IN VIVO INSERTION UTILIZING A BIOCOMPATIBLE MATERIAL

Resumen de: KR20250090887A

생체적합성 재료를 활용한 체내 삽입용 보형물이 개시된다. 본 발명의 일측면에 따른 체내 삽입용 보형물은 인체에 삽입되는 체내 삽입용 보형물로서, 키토산(chitosan), 키틴(chitin), 폴리데옥시 리보뉴클레오티드(polydeoxyribonucleotide; PDRN), 폴리뉴클레오티드(polynucleotide; PN), 폴리카프로락톤(polycaprolactone; PCL), 수산화인회석(hydroxyapatite) 및 골형성단백질2(bone morphogenetic protein 2; BMP-2)로 이루어진 군으로부터 선택되는 적어도 하나의 생체적합성 재료를 함유하는 복수의 선부재를 포함할 수 있고, 여기서 상기 복수의 선부재는 서로에 대해 교차하도록 결합되어 3차원 구조를 구성할 수 있다.

3D PRINTED DENTAL APPLIANCES WITH VARIABLE THICKNESS REGIONS

Resumen de: US2025195174A1

Dental appliances for treatment of a patient's dentition are provided. In some embodiments, a dental appliance includes a plurality of 3D printed polymer layers, where the plurality of 3D printed polymer layers includes a plurality of sequentially polymerized appliance cross-sections. The dental appliance can include an appliance shell formed from the plurality of sequentially polymerized appliance cross-sections. The appliance shell can include a plurality of tooth receiving cavities formed from the plurality of sequentially polymerized appliance cross-sections, the plurality of tooth receiving cavities arranged to receive a dentition and to exert one or more forces on the dentition, and a plurality of variable thickness regions formed from the plurality of sequentially polymerized appliance cross-sections. The plurality of variable thickness regions can include a corresponding plurality of different appliance thicknesses, and the plurality of variable thickness regions can be arranged to implement one or more treatment outcomes.

A METHOD FOR MANUFACTURING A PERFUSABLE THREE-DIMENSIONAL TISSUE MODEL WITH 3D BIOPRINTING TECHNOLOGY, AND A TISSUE MODEL PRODUCED WITH THIS METHOD

Resumen de: US2025197813A1

A method For manuFacturing a perFusable three-dimensional tissue model, containing therein a channel distributed across its entire structure, enabling the Flow oF Fluids, wherein bioprinting a vascular system with the extrusive method using bioink, the walls opening and closing the channel in its upper part being printed parallel to the channel axis, and bioprinting oF the model body with the extrusive method using bioink, the bioink For printing the body being diFFerent From the bioink used For bioprinting the vessels, placing the resulting system in an incubator, in a temperature in which bioink For printing the vascular system undergoes melt, removing the bioink, optionally, causing growth in the channel by means oF cells in a medium, wherein, the cross-section oF the channel being the same as the cross-section oF native vessels present in a living organism. The inventions relates to a bionic model with a perFusable system.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: WO2025128946A1

Disclosed herein are devices and methods of making and use thereof.

ELECTROMAGNETIC DROP-ON-DEMAND (DOD) TECHNOLOGY AS AN INNOVATIVE PLATFORM FOR AMORPHOUS SOLID DISPERSION PRODUCTION

Resumen de: WO2025128987A1

Described are continuous manufacturing methods using 3D printing or any similar additive manufacturing technology to produce pharmaceutical ASDs. Manufacturing methods include preparing printing ink including API and polymeric carriers. The printing ink is accurately deposited onto a deposition surface by forming printing ink droplets by using an electromagnetic DoD 3D printing device to form an ASD printed product. The ASD printed product has improved solubility and bioavailability than the API in crystalline form.

SYSTEMS AND METHODS FOR ORTHOPEDIC IMPLANTS

Resumen de: US2025195230A1

A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.

PRINTING MECHANISM FOR MEDICAL MONITORING DEVICE AND MEDICAL MONITORING DEVICE

Resumen de: US2025196517A1

The present invention provides a printing mechanism for a medical monitoring device and a medical monitoring device. The printing mechanism comprises a movable frame assembly comprising a frame and a print paper drawer for holding the print papers, the print paper drawer being mounted on the frame to move along with the movable frame assembly, wherein a front end wall of the print paper drawer is formed as a curved wall comprising a first portion extending perpendicularly from a front end of a bottom plate of the print paper drawer and a second portion extending from the first portion and bending towards a rear end of the print paper drawer with respect to the first portion, and the second portion forms an anti-tilting surface for preventing the print papers from tilting. According to the printing mechanism for the medical monitoring device of the present invention, the end of the print papers contacting the anti-tilting surface does not slip and tilt during printing while the smoothness in feeding the print paper to the printing head is not affected.

IMPLANT COMPONENTS AND METHODS

Resumen de: US2025195231A1

Systems, devices, and methods are provided for orthopedic implants. The implants may include a base member, such as an acetabular shell or an augment, that is configured to couple with an augment, flange cup, mounting member, or any other suitable orthopedic attachment.

SYSTEM AND METHODS FOR MIXED REALITY SURGICAL SIMULATION

Resumen de: US2025195144A1

A system for mixed reality surgical simulation is provided. The system includes a simulator, an optical tracking system, an input device, a visualization screen, and a simulation workstation, wherein the simulation workstation renders an augmented view on the visualization screen.

PHOTOCURABLE COMPOSITION, THREE-DIMENSIONAL MODELING PRODUCT, MOLD, METHOD OF PRODUCING CURED PRODUCT, AND METHOD OF PRODUCING PLATE DENTURE

Nº publicación: US2025196403A1 19/06/2025

Solicitante:

MITSUI CHEMICALS INC [JP]
MITSUI CHEMICALS, INC

Resumen de: US2025196403A1

A photocurable composition, contains a (meth)acrylic monomer component, and photopolymerization initiator, in a case in which a rectangular sheet-like test piece A1 with a length of 40 mm, a width of 10 mm, and a thickness of 1.0 mm is produced by photomodeling under conditions in which the photocurable composition is irradiated with visible light having a wavelength of 405 nm at an irradiation dose of 11 mJ/cm2 to form a cured layer A1 with a thickness of 50 μm, the cured layer A1 is stacked in a thickness direction thereof to form a rectangular sheet-like modeling product A1 with a length of 40 mm, a width of 10 mm, and a thickness of 1.0 mm, and the modeling product A1 is irradiated with ultraviolet rays having a wavelength of 365 nm at an irradiation dose of 3 J/cm2 to produce the test piece A1.