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DATABASE MANAGEMENT AND GRAPHICAL USER INTERFACES FOR MEASUREMENTS COLLECTED BY ANALYZING BLOOD

Resumen de: EP4790717A1

0001 Methods and devices include database management and graphical user interfaces for measurements collected by analyzing blood

糖尿病への転化を予測する多重マーカリスクパラメータ

Resumen de: WO2015103553A1

Methods, systems and circuits evaluate a subject's risk of developing type 2 diabetes using defined mathematical models of short term risk (STR) and longer term risk of progression. The evaluations can stratify risk for patients having the same glucose measurement, particularly those with intermediate or low (normal) fasting plasma glucose (FPG) values. The STR or IR (insulin resistance) model(s) may include an inflammatory biomarker such as an NMR derived measurements of GlycA and a plurality of selected lipoprotein components of at least one biosample of the subject. Embodiments of the invention also provide methods, systems and circuits that generate STR scores as a marker of beta-cell dysfunction or impairment.

DISTRIBUTED DEVICE CONTROL AND WEARABLE SYSTEM FOR VAGUS NERVE STIMULATION

Resumen de: EP4790724A2

A stimulation system may include a sensor configured to detect a physiological signal of a user, the physiological signal having a biomarker therein associated with a disorder of the user; a stimulator configured to deliver electrical stimulation to the user; and a hub device configured to receive the physiological signal from the sensor and to output a control signal to the stimulator. The control signal may cause the stimulator to deliver electrical stimulation to the user according to a stimulation protocol, the stimulation protocol treating the disorder. The hub device may be configured to output the control signal based on the biomarker of the received physiological signal. The hub device may be configured to generate another control signal for treating another disorder based on a biomarker not included in the physiological signal received from the sensor.

METHODS AND APPARATUSES FOR CUSTOMIZING RAPID PALATAL EXPANDERS USING DIGITAL MODELS

Resumen de: EP4789638A2

0001 Methods for designing and fabrication of a series of apparatuses for expanding a patient's palate ("palatal expanders"). In particular, described herein are methods and apparatuses for forming palatal expanders, including rapid palatal expanders, as well as series of palatal expanders formed as described herein and apparatuses for designing and fabricating them. A method of forming a palatal expander comprises adjusting a digital model of a patient's oral cavity, wherein the digital model comprises a digital model of the patient's teeth, gingiva and palate, from an initial position to a second position in which the palate is expanded by morphing the digital model to reflect an orthopedic expansion of the patient's midline suture; generating a palatal expander model corresponding to the second position and adding anti-tipping torque to one or more teeth in the generated palatal expander model; and fabricating a palatal expander from the generated palatal expander model with the added anti-tipping torque.

重合可能なモノマー及び其れ等を重合する方法

Resumen de: JP2024119950A

To provide photopolymerizable monomers for use as reactive diluents in a high temperature lithography-based photopolymerization process.SOLUTION: The present invention provides a polymerizable monomer represented by formula (I).SELECTED DRAWING: Figure 1A

猪上颚脱细胞基质膜片、口腔软组织复合材料及制备方法

Resumen de: CN122537602A

本发明涉及一种猪上颚脱细胞基质膜片、口腔软组织复合材料及制备方法；其中，口腔软组织复合材料的制备方法包括：利用目标打印材料构建纤维支架，并将所构建出的纤维支架作为复合材料的下层骨架；利用粘合剂所制备的粘合剂膜，将所述猪上颚脱细胞基质膜片粘接在所述下层骨架上，得到由所述猪上颚脱细胞基质膜片和纤维支架所形成的复合材料。本发明所制备出的复合材料兼具优异生物活性、力学稳定性和免疫调节功能，解决现有的口腔软组织修复材料来源有限、生物相容性不足、降解与再生不匹配、力学性能弱、缺乏免疫调控能力等问题。

移动除颤器

Resumen de: WO2022018671A1

A method for performing CPR with a mobile defibrillator (AED) unit can include detecting, via an application on a user device, a connection of a mobile AED unit to the user device; detecting, via the application, that pads have been attached to a subject, the pads comprising at least one accelerometer; recording, via the application, EKG measurements of the subject made by the pads; receiving accelerometer data from the at least one accelerometer; analyzing the accelerometer data to determine a breathing pattern of the subject; and based on the determined breathing pattern, initiating a CPR protocol.

一种共价反应制备的新型的3D结构生物高分子材料及其制备方法

Resumen de: CN122541838A

本发明属于生物高分子材料技术领域，具体涉及一种共价反应制备的新型的3D结构生物高分子材料及其制备方法。以质量份数计，所述3D结构生物高分子材料包括如下原料：复合高分子基材6‑12份、反应添加剂0.5‑3份、助剂6‑8份和水150‑300份；所述复合高分子基材包括：可溶性甲壳素类高分子材料、玻尿酸和纤维素钠。本发明采用共价交联反应构筑三维立体网络结构，显著增强材料柔韧性、耐水性，延缓高分子基材降解速率，安全无毒、无化学残留刺激风险，绿色环保，不仅凝血率好且抑菌效果佳，在食品抑菌防腐、医用防护、生物包装等领域具备良好的应用价值与推广前景。

一种提高纯锌生物材料力学性能的方法

Resumen de: CN122538815A

本发明公开了一种提高纯锌生物材料力学性能的方法，该方法通过在激光粉末床熔融成形过程中，针对每一层初始熔化沉积层立即执行特定功率梯度的原位激光第二次扫描。本发明利用原位重熔诱导的二次热循环效应，强行中断纯锌在极端非平衡凝固下形成的外延生长粗大柱状晶，使其发生晶粒破碎并重构为细小、近等轴的晶粒结构。同时，通过重熔热激活机制触发非基面滑移系的开启，调控施密特因子分布并提升高角度晶界占比，从而在不添加任何合金元素的前提下，使纯锌材料在维持高强度的同时获得惊人的塑性提升，有效解决了增材制造纯锌植入物强度与塑性失配及力学各向异性的难题，为高性能个性化生物可降解锌基植入物的开发提供了核心工艺策略。

一种苯硼酸改性壳聚糖/芦荟苷抗菌水凝胶及其制备方法

Resumen de: CN122537581A

本发明涉及生物医用材料技术领域，具体涉及一种苯硼酸改性壳聚糖/芦荟苷抗菌水凝胶及其制备方法。具体技术方案为：该方法先采用4‑羧基苯硼酸对壳聚糖进行接枝改性，制得苯硼酸改性壳聚糖；再将壳聚糖衍生碳量子点分散于醋酸水溶液中，并用于溶解苯硼酸改性壳聚糖，得到含碳量子点的苯硼酸改性壳聚糖溶液；随后将其与芦荟苷溶液混合，在碱性条件下交联成胶，并经静置、水浴、透析和冷冻干燥得到目标产物。所得水凝胶兼具自愈合性能、抗菌性能和荧光示踪功能。该制备方法简便、条件温和，所得水凝胶在抗菌敷料、创面覆盖材料和功能生物医用材料领域具有应用价值。

基于3D打印基座的颅脑无创精准定位导航系统

Resumen de: CN122537122A

本发明涉及颅脑手术导航技术领域，具体公开了一种基于3D打印基座的颅脑无创精准定位导航系统，包括：3D打印定位基座与患者头面部解剖轮廓贴合，内部集成传感器阵列，所述3D打印定位基座本体设置超声适配窗口，用于超声探头限位与位移测量；多模态数据预处理模块用于对术前影像及多源感知数据进行标准化预处理与全自动分割。本发明巧妙利用与患者生理轮廓贴合的3D打印定位基座作为无创操作载体，不仅有效避免了传统刚性头架打入金属颅骨钉带来的较大创伤与感染风险，还通过基座内部集成的传感器阵列与超声探头协同工作，在术中持续且无创地获取表层全域形变数据与深层皮骨相对位移真值。

一种血管内超声诊断系统

Resumen de: CN122537049A

0001 本发明涉及超声诊断技术领域，具体涉及一种血管内超声诊断系统，包括超声探测模块、信号处理模块、图像重建与分析模块、控制模块、人机交互模块和数据存储与传输模块；超声探测模块在血管内待测部位，发射超声信号并接收血管内组织的回波信号并转换为数字信号；信号处理模块对数字信号进行处理，优化信号质量；图像重建与分析模块将信号处理模块输出的特征信号重建为血管内可视化图像，并进行智能分析，识别病变类型与程度，该系统采用多频可调超声换能器，结合差异化信号处理策略，实现血管内不同深度组织的精准探测，集成智能图像重建与病变分析算法，自动识别病变类型、测量相关参数，生成标准化诊断报告，提升诊断效率与准确性。

Dual patch system for measuring tissue properties

Resumen de: US12702859B1

0000 Provided herein are medical patches and dual patch systems for real-time post-operative monitoring of tissue properties and flap monitoring. The medical patch may be a flap patch that has modules to measure tissue oxygenation and skin temperature and to deliver a therapy to the tissue and to control the flap patch or may be a reference patch configured to also measure ambient temperature. Both the flap patch and the reference patch additionally may be configured to detect edema. The dual patch system has the flap patch, a reference patch and a reference module. Also provided is a method for real-time monitoring and modulating tissue health in a surgical flap via the dual patch system.

用于消毒供应中心的无菌交付控制方法、系统及服务器

Resumen de: CN122552061A

0001 本发明提供了一种用于消毒供应中心的无菌交付控制方法、系统及服务器，涉及医疗器械交付控制领域，该方法利用目标消毒供应中心对应的使用场景数据生成相应的匹配内容数据和空间布置数据得到目标消毒供应中心对应无菌交付控制策略，实现了消毒供应中心无菌物品交付的全流程闭环管控，在实现无菌防护升级、流转效率提升、空间利用优化的同时，完成了物资管理的精细化与规范化，兼具规范性、实用性与适配性，大幅降低了医疗机构消毒供应中心的运营管理成本与感染管控风险，从而解决上述技术问题。

一种柔性脑肌电电极阵列

Resumen de: CN122537024A

本申请提供了一种柔性脑肌电电极阵列，该柔性脑肌电电极阵列包括：柔性基底、分布式电极界面单元、信号互连结构、多物理场传感模块以及信号处理与传输模块。在上述技术方案中，解决了现有技术在长期稳定、高保真同步采集脑肌电信号时面临的界面失稳、互连易损、伪影干扰大、功能单一的难题。

一种情绪识别并触发的互动式艺术疗愈装置

Resumen de: CN122537658A

0001 本发明公开了一种情绪识别并触发的互动式艺术疗愈装置，属于心理健康与人机交互领域。包括：图像采集模块，用于采集用户面部图像；表情识别模块，用于识别是否为积极情绪；控制模块，用于在识别到积极情绪时生成控制信号；机械驱动模块，用于产生机械运动；动画展示模块，包括可相对往复运动的栅格片和底板画框，由机械运动驱动产生动态动画效果；以及电源模块。本发明将用户的积极情绪实时转化为驱动实体栅格动画的物理运动，构建了无评判的、即时正向反馈闭环，避免了情绪标签带来的心理压力，并将抽象的动画原理转化为具身的艺术互动体验。装置一体化、便携化，可灵活部署于公共空间，有效提升用户积极情绪和参与感。

基于大数据的黔金丝猴健康状况辅助诊断系统

Resumen de: CN122552086A

0001 本发明公开了一种基于大数据的黔金丝猴健康状况辅助诊断系统，旨在解决现有黔金丝猴监测效率低、精准度不足、野外监测适配性差的技术痛点。该系统包括多源异构数据采集模块、大数据处理与特征融合模块、智能诊断建模模块及可视化管理平台。针对圈养种群和野外种群采用差异化采集策略，整合多维度数据，经清洗、特征融合后，通过定制化混合机器学习模型实现健康等级判断与异常预警。本系统填补野外种群健康监测空白，积累专属健康大数据，助力疫病早期预警，形成可推广的濒危物种监测模式，为黔金丝猴种群保护提供技术支撑。

一种柔性放疗组织补偿物的成形优化方法及系统

Resumen de: CN122539653A

本发明涉及组织补偿物的成形技术领域，公开了一种柔性放疗组织补偿物的成形优化方法及系统，该方法包括：获取三维模型、各位置设计厚度及材料参数，生成候选打印姿态；提取分析单元的悬垂角、自由跨距、局部壁厚、曲率半径和边界距离，计算允许成形变形量、最大下垂位移及累计偏差值，确定目标打印姿态；进行边缘光顺、厚度修正、打印参数调整和水溶性PVA支撑路径生成，并生成切片路径数据控制打印。本发明通过打印姿态量化优选和多维度分级修正，可将柔性TPU补偿物的打印厚度偏差从传统方法的>0.3mm降至<0.1mm，表面粗糙度Ra<6.3μm，满足放疗临床剂量分布精度要求。

口腔附件的生成方法及相关设备

Resumen de: CN122537138A

本申请实施例提供一种口腔附件的生成方法及相关设备，方法包括：获取对象的口腔扫描数据；至少基于口腔扫描数据和至少部分设计参数，生成位于对象牙齿唇侧的附着带，其中，生成的附着带低于牙齿的上表面；以及将标记本体附接到附着带生成口腔附件，其中，标记本体包括一个或多个可以追踪的标记。

一种脊柱侧弯矫形器的有效穿戴质量评估方法及装置

Resumen de: CN122536951A

本发明公开了一种脊柱侧弯矫形器的有效穿戴质量评估方法及装置；本发明先基于接触置信度及其在预设时间窗口内的接触稳定性特征构建有效穿戴门控条件，在所述有效穿戴门控条件成立时，调用交付标定基准，并根据姿态/运动相关数据识别当前姿态或运动状态，再根据当前姿态或运动状态调用对应状态基准，对压力相关数据进行分状态压力有效性评价，计算压力有效性参数，进而结合姿态/运动匹配参数和时间窗口稳定性参数计算有效穿戴质量指数，可对患者日常穿戴状态是否持续符合交付标定基准进行量化评估，从而实现对未穿戴、穿戴接触不足、压力作用异常和有效穿戴等状态的区分识别、时长统计及提示输出。

用于将牙科辅助件定位在牙齿上的装置和方法

Resumen de: WO2025097054A1

Devices, methods, and systems for placing dental auxiliaries on teeth are provided. In some embodiments, for example, a dental auxiliary positioner for placing a dental auxiliary on a tooth includes: a registration element configured to receive a patient's tooth; and an auxiliary support coupled to the registration element and further coupled to an auxiliary, where the auxiliary support is configured to position the auxiliary against a surface of the tooth, and where the auxiliary support includes a frame extending at least partially around the auxiliary, one or more struts coupling the auxiliary to the frame, and a flexible bridge coupling the frame to the registration element, where the flexible bridge is configured to bend in one or more directions relative to the tooth to adjust the position of the auxiliary on the surface of the tooth.

用于龋齿检测的方法和设备

Resumen de: WO2025102059A1

Methods and apparatuses for dental caries detection and communication. These methods and apparatuses may be used in real time, as part of an intraoral scanning system, or at any point following intraoral scanning. These methods and apparatuses may use a plurality of different images of the teeth, each having two or more fields (e.g., wavelengths such as visible light, near-infrared, fluorescent, etc.), and may use a trained pattern matching agent to detect possible caries centers from each image, then may project some or all of the possible caries centers onto a 3D model of the teeth to identify consensus caries and caries centers.

一种生物打印材料及其制备方法和应用

Resumen de: CN122537588A

本发明公开了一种生物打印材料及其制备方法和应用。按重量份数计，生物打印材料包括如下组分：聚氨酯18‑42份，胶原蛋白28‑52份，壳聚糖8‑22份，交联剂2‑6份，增塑剂3‑8份，生物活性因子1‑5份；交联剂选自京尼平或水溶性的异氰酸酯中的至少一种；增塑剂包括质量比为（1‑3）：1的聚乙二醇和多元醇；所述聚乙二醇的数均分子量为400‑2500Da；壳聚糖的脱乙酰度≥85%，所述壳聚糖的数均分子量为45‑210kDa。所述生物打印材料具有优异的耐弯折性能和断裂伸长率，表面平整光滑，无明显开裂产生。

複数のロック可能な薬剤容器のためのシステムおよび方法

Resumen de: WO2024263307A1

The present discloser provides methods and systems related to a medication container that may be locked using a locking mechanism. In one exemplary method, a request from a user may be received by a medication provider for a medication. The medication may be placed in a medication container with a locking mechanism that is operable to lock and unlock the medication container. The medication container may be locked using the locking mechanism. The locked medication container with the medication within may be provided to the user. Subsequent to providing the locked medication container to the user, a request may be received from the user to access the medication in the medication container. A credential may be sent to the user that is usable, via the locking mechanism, to unlock the medication container. The user may then input the credential into the locking mechanism to unlock the medication container and access the medication therein.

動的熱補償のためのシステム及び方法

Nº publicación: JP2026526736A 10/08/2026

Solicitante:

アルコンインコーポレイティド

Resumen de: WO2025027460A1

Embodiments of the present disclosure generally relate to systems and methods for measuring intraocular pressure (IOP) during ophthalmic surgery. In some embodiments, a method for measuring IOP is provided. The method includes measuring fluid pressure in a fluid flow path of a handpiece device using a pressure sensor disposed therein to obtain a fluid pressure measurement, determining a sensor temperature measurement of the pressure sensor, determining a predicted sensor zero offset based on the sensor temperature measurement using a determined zero offset correlation function, and adjusting the fluid pressure measurement with the predicted sensor zero offset to obtain an adjusted fluid pressure measurement.