Alerta

ADAPTIVE UPDATE OF AUTOMATIC INSULIN DELIVERY (AID) CONTROL PARAMETERS

Resumen de: US2025339617A1

Exemplary embodiments may modify the cost function parameters based on current and projected mean outcomes in blood glucose level control performance. The exemplary embodiments may modify the weight coefficient R for the insulin cost so that the value of R is not fixed and is not based solely on clinical determined values. Exemplary embodiments may also adjust the cost function to address persistent low-level blood glucose level excursions for users. The exemplary embodiments may reduce the penalty of the insulin cost by the sum of the converted insulin cost of the glucose excursions above target for a period divided by a number of cycles of average insulin action time. The AID system reduces the insulin cost by the lack of insulin in previous cycles.

NON-INVASIVE PREDICTION OF INSULIN RESISTANCE USING SENSOR DATA

Resumen de: WO2025231209A1

A computing system, a computer implemented method, and a wearable computing device to predict insulin resistance in a wearer of the wearable computing device without requiring additional invasive testing other than test data that may already be available, although not required, is provided. For instance, a machine-learned model is trained to predict insulin resistance in the wearer of the wearable computing device based at least in part on non-invasive biometric data associated with the wearer. Then, one or more non-transitory computer-readable media cause the computing system to perform operations via one or more processors. The operations include receiving the non-invasive biometric data from one or more sensors associated with the wearable computing device; and implementing the machine-learned model to determine if the non-invasive biometric data associated with the wearer is indicative of insulin resistance.

IMPLANT APPARATUS FOR CONTINUOUS BLOOD GLUCOSE MONITOR

Resumen de: EP4643774A1

Provided is an implant apparatus for a continuous glucose monitor. The implant apparatus includes a housing assembly and a driving assembly disposed in the housing assembly. The housing assembly includes an outer housing. The outer housing has an opening at an end of the outer housing. The driving assembly has a locked state in which the driving assembly is fixed relative to the outer housing and a triggered state in which the driving assembly is movable towards the opening. The implant apparatus further includes a trigger. The outer housing includes a guiding channel located at a side wall of the outer housing and extending towards the opening. The trigger is movable along the guiding channel towards the opening and has a first position and a second position relative to the outer housing, to enable the driving assembly to switch from the locked state to the triggered state. A triggering direction of the trigger is oriented towards the opening, while a direction of a force applied by fingers of a user when the user holds the outer housing is oriented inwards in a radial direction of the outer housing. Force application directions of the two actions are perpendicular to each other. As a result, a probability of the user accidentally triggering the trigger when holding the outer housing is reduced, which reduces a risk of accidental triggering of the implant apparatus, improving use experience.

SELF-LUBRICATING REFLOWING INFUSION CATHETER

Resumen de: EP4643910A1

The present disclosure relates to a self-lubricating cannula for use in delivering a fluid medication to a subcutaneous site. The self-lubricating cannula comprises polyether block polyamide and an additive configured to facilitate the manufacture of a tipped self-lubricating cannula. The present disclosure also provides a method of making a self-lubricating cannula and a method of administering insulin using a self-lubricating cannula.

PFAS-FREE INFUSION CANNULAS

Resumen de: EP4643911A1

The present disclosure relates to the use of a PFAS-free cannula in delivering a fluid medication, such as insulin, to a subcutaneous site. The cannula comprises polycarbonate polyurethane polysiloxane (PC-PU-PS), wherein the cannula is configured for subcutaneous insertion into the tissue of the individual in need thereof. The disclosure includes methods for administering insulin using the cannula and infusion devices comprising the cannula.

SENSING SYSTEMS AND METHODS FOR HYBRID GLUCOSE AND KETONE MONITORING

Resumen de: AU2023415722A1

Certain aspects of the present disclosure relate to a monitoring system comprising a continuous analyte sensor configured to generate analyte measurements associated with analyte levels of a patient, and a sensor electronics module coupled to the continuous analyte sensor and configured to receive and process the analyte measurements.

ANALYTE SENSORS AND SENSING METHODS FEATURING DUAL DETECTION OF GLUCOSE AND KETONES

Resumen de: EP4643777A1

Glucose and ketones may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using an analyte sensor capable of detecting both analytes. Certain analyte sensors capable of dual detection may comprise a first working electrode and a second working electrode, a ketones-responsive active area disposed upon a surface of the first working electrode, a glucose-responsive active area comprising a glucose-responsive enzyme disposed upon a surface of the second working electrode, a membrane having a first portion overcoating the ketones-responsive active area and a second portion overcoating the glucose-responsive active area, in which the first portion and the second portion have different compositions. The ketones-responsive active area comprises an enzyme system comprising at least two enzymes that are capable of acting in concert to facilitate detection of ketones.

Management process for insulin therapy using reinforcement learning and therapy escalation pathways

Resumen de: WO2024211880A2

A method of therapy escalation for patients with diabetes includes receiving glucose data of a user from an in vivo glucose monitoring device, receiving first therapy information of a first therapy, wherein the first therapy includes basal insulin, calculating one or more glucose metrics based on the received glucose data, titrating a dose of the basal insulin based on the one or more glucose metrics, and determining overbasalization based on one or more of the glucose data and the first therapy information. Advantageously the system can regularly monitor glucose control of a user, detect overbasalization, provide frequent therapy intervention and adjustment, decrease a duration of intervention, and increase user adherence, outcomes, and satisfaction.

BLOOD GLUCOSE METER

Resumen de: US2025331738A1

A blood glucose meter (10) comprises a main body part (11), a sensor mounting part (13), a measurement unit (14), a battery compartment (11a), a battery cover (12), a hinge (21), a lock pin (21a), and sliding surfaces (SL1, SL2). The battery cover (12) has an opening (12a) into which a jig Z is inserted during removal from the body portion (11). The hinge (21) deforms when pressed by the jig (Z) inserted through the opening (12a). The lock pin (21a) is provided at a position where it is exposed to the outside through the opening (12a), and when pressed by the jig (Z), the battery cover (12) is unlatched from the main body portion (11). When the battery cover (12) is slid along the sliding surfaces (SL1 and SL2) in a state in which the battery cover (12) is latched to the main body portion (11) by the lock pin (21a), a force in a compression direction is exerted on the hinge (21).

SYSTEMS AND METHODS FOR PROVIDING THERAPY MANAGEMENT GUIDANCE FOR DIAGNOSIS AND MANAGEMENT OF KIDNEY DISEASE

Resumen de: WO2025226760A1

Certain aspects of the present disclosure provide a monitoring system comprising one or more memories comprising executable instructions and one or more processors in data communication with the one or more memories and configured to execute the executable instructions to calculate a first reabsorption threshold based on glucose measurements and 1,5-AG measurements of a patient over a first period of time and calculate a second reabsorption threshold based on the glucose measurements and the 1,5-AG measurements of the patient over a second period of time. The one or more processors are further configured to detect a change of the second reabsorption threshold relative to the first reabsorption threshold; determine whether the change of the second reabsorption threshold relative to the first reabsorption threshold is an increase or a decrease; and provide therapy management guidance to the patient based on the increase or the decrease.

ARTIFICIALLY INTELLIGENT SYSTEM FOR MEDICATION MANAGEMENT

Resumen de: US2025331781A1

An artificially intelligent, voice-based method for prescribing, managing and administering at least one medication for management of type 2 diabetes to a patient. Aspects of the present disclosure provide for a system and method for configuring one or more clinical algorithms according to one or more clinical protocols to configure a conversational AI model. The conversational AI model is configured to drive a conversational AI agent configured to facilitate a plurality of multi-turn conversational interactions between a patient user and the conversational agent to enable automated initiation and titration of one or more diabetes medications for the patient.

WORKING WIRE FOR A CONTINUOUS GLUCOSE MONITORING SENSOR

Resumen de: US2025334537A1

A method of manufacturing a working wire for a continuous glucose monitoring sensor includes receiving a substrate in a wound configuration. The substrate consists of a cobalt-chromium (Co—Cr) alloy. The substrate is unwound from the wound configuration. The substrate is allowed to naturally transition to a straight, linear configuration. A platinum layer is formed on the substrate. A membrane layer comprising a biological membrane is applied over the platinum layer. The working wire is formed to have a diameter in a range from 0.0025 inches to 0.005 inches. A working wire for a continuous glucose monitoring sensor includes a substrate consisting of a cobalt-chromium (Co—Cr) alloy, a platinum layer disposed on the substrate and a membrane layer comprising a biological membrane disposed over the platinum layer. A diameter of the working wire is in a range from 0.0025 inches to 0.005 inches.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Resumen de: US2025338210A1

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are provided. The data can be displayed on a hand-held display device having a display such as a key fob device including a user interface, such as an LCD and one or more buttons allows a user to view data, and a physical connector, such as USB port.

ADJUSTABLE GLUCOSE SENSOR INITIALIZATION SEQUENCES

Resumen de: US2025331743A1

Techniques disclosed herein relate to adjustable glucose sensor initialization sequences. In some embodiments, the techniques may involve determining an initial amplitude of one or more voltage pulses of a sequence of voltage pulses applied to a working electrode of the glucose sensor that is at least partially inserted subcutaneously in a patient. The techniques may further involve determining a slope of one or more parameters of the glucose sensor. The techniques may further involve determining an updated amplitude of the one or more voltage pulses based on the slope of the one or more parameters. The techniques may further involve executing an initialization sequence using the one or more voltage pulses having the updated amplitude to the working electrode of the glucose sensor.

USE OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS) IN CONTINUOUS GLUCOSE MONITORING

Resumen de: US2024423495A1

Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

TEMPORALLY ALIGNING PHYSIOLOGICAL PARAMETER MEASUREMENTS

Resumen de: US2025331741A1

A system includes an implantable medical device configured to measure blood-glucose concentration based on cardiac activity. The system further includes processing circuitry configured to generate, based on the plurality of periods, a plurality of waveforms representative of the blood-glucose concentration. The processing circuitry is further configured to identify at least one clinically significant feature that is present in each waveform. The processing circuitry is further configured to modify one or more of the plurality of waveforms such that the at least one feature is temporally aligned across the plurality of waveforms.

MULTI-ANALYTE SENSING AND MEDICATION CONTROL

Resumen de: US2025331740A1

A multi-analyte sensor system is disclosed. The system includes a sensor probe that has a first set of electrodes that transduce glucose into electrical signals, a second set of electrodes that transduce lactate into electrical signals and a third set of electrodes that provide working and counter electrode functionality for the first and second set of electrodes. The system has an electronics module that electrically interfaces with the sensor probe, and includes a transceiver configured to transmit sensor data. The system also includes control circuitry communicatively coupled to the electronics module that determines a glucose state based on signals from the first set of electrodes and also determine a lactate state based on signals from the second set of electrodes. The control circuitry also generates an insulin infusion pump control signal based on signals from the first and second set of electrodes.

Estimation Method, Estimation Program, Estimation System, Determination Method, and Estimation Marker

Resumen de: US2025331739A1

An estimation method includes: obtaining a measurement value of advanced glycation end products of a subject; and estimating, using a correlation between a measurement value of advanced glycation end products and a blood glucose spike frequency prepared in advance, a blood glucose spike frequency of the subject based on the measurement value of advanced glycation end products of the subject obtained in the obtaining.

PROCESSING METHOD AND APPARATUS FOR PPG SIGNAL-BASED BLOOD GLUCOSE PREDICTION MODEL

Resumen de: WO2025222911A1

A processing method and apparatus for a PPG signal-based blood glucose prediction model. The processing method for a PPG signal-based blood glucose prediction model comprises: constructing a PPG signal-based blood glucose prediction model and recording same as a first prediction model; constructing a first original data set by means of data acquisition; performing data preprocessing on the first original data set to obtain a first training data set; performing model training on the first prediction model on the basis of the first training data set; and when the training is finished, performing blood glucose prediction for an arbitrary subject on the basis of the first prediction model. The present invention can improve user experience and enhance user's motivation for self-monitoring.

Insulin injection pen

Resumen de: CN223474221U

The insulin injection pen comprises an injector body, an injection assembly and a limiting mechanism, the injector body comprises an opening, the opening is formed in one end of the injector body, the injection assembly comprises a needle seat and a needle tube, the needle seat comprises a containing cavity, the needle seat is inserted in the opening so that the needle tube can be conveniently installed, one end of the needle tube is connected with the needle seat, and the limiting mechanism is arranged on the needle tube. And the cavity is communicated with the accommodating cavity. According to the insulin injection pen, due to the adoption of the technical means of the limiting mechanism, when the insulin injection pen is in a working state, the limiting piece enables the needle seat to be firmly connected with the injector main body, the stability and accuracy of the injection process are ensured, and in a non-working state, the limiting piece is separated from the main body, so that the needle seat is convenient to disassemble and treat. According to the technical scheme, the problems that an existing injection pen needle is complex to disassemble and large in potential safety hazard are effectively solved, operation simplicity and use safety are improved, and then automation, convenience and safety of the insulin injection pen are achieved.

Multifunctional sharp instrument barrel

Resumen de: CN223473893U

The utility model relates to the technical field of sharp instrument collection, in particular to a multifunctional sharp instrument barrel which comprises a barrel body and a detachable top cover at the top of the barrel body, inclined faces are arranged on the two sides of the top cover, each inclined face is provided with a sliding knife groove and a needle taking opening penetrating through the top cover, and a tube cutting assembly is clamped in the sliding knife groove in a sliding mode. The top of the tube cutting assembly is connected with a drag hook spring, the top of the drag hook spring is connected to the top of the top cover, the bottom of the tube cutting assembly is rotationally connected with a rotating pull ring, and a needle clamping ring is fixed to the bottom of the needle taking opening. The design of the tube cutting assembly is adopted, an infusion tube can be cut off, so that when a needle on the infusion tube falls into the barrel body to be collected and reset, the insulin injection needle clamped on a needle clamping ring can be pushed into the barrel body, and through the special design of the needle clamping ring, the needle clamping ring can be used for clamping the insulin injection needle and can also be used for clamping the insulin injection needle. And the clamping grooves formed between the clamping pieces can be used for clamping common injection needles, so that the effect of taking out and collecting various needles is realized.

Experiment auxiliary device for automatically detecting sweet water preference of small animals

Resumen de: CN223472802U

The utility model relates to an experiment auxiliary device for automatically detecting sweet water preference of small animals, which comprises an experiment box with a pick-and-place door, a camera, two drinking water bottles used for filling common drinking water and cane sugar water respectively, a trough used for placing food and a controller electrically connected with an external power supply, the camera is in signal connection with the controller, and the controller is in signal connection with the camera. The camera and the feeding trough are arranged in the experiment box, the controller is in signal connection with a timing module, a motor is arranged at the upper end of the experiment box, the motor is electrically connected with an external power source through the controller, and the output end of the motor extends into the experiment box and is fixedly connected with a rotating disc used for installing two drinking water bottles. According to the utility model, the situations of inaccurate experimental results and deviation of the experimental results caused by the habit preference of drinking water of the experimental mouse can be avoided, the accuracy of the experimental results is improved, and the experimental representativeness is strong.

Insulin infusion device, insulin infusion system, and storage medium

Resumen de: CN120827652A

The invention relates to an insulin infusion device, an insulin infusion system and a storage medium. The device comprises a memory and a processor, a computer program is stored in the memory, the processor executes the steps of the insulin infusion control method when executing the computer program, and the method comprises the steps that real-time monitoring blood glucose data and historical blood glucose data of a user are obtained; calling an initial insulin infusion model pre-stored in the insulin infusion equipment; adjusting preset parameters of the initial insulin infusion model according to the historical blood glucose data to obtain an insulin infusion model; according to the real-time monitoring blood glucose data and the insulin infusion model, the insulin dosage is determined. The preset parameters in the insulin infusion model are adaptively adjusted, so that the adjusted insulin infusion model is more matched with the individual blood glucose change level of the user, the accuracy of the insulin dosage is improved, a more matched and accurate insulin infusion scheme is provided for different users, and the blood glucose control effect of the different users is improved.

Insulin infusion device, storage medium and program product

Resumen de: CN120827653A

The present application relates to an insulin infusion device, a storage medium and a program product, the device comprising at least one memory and at least one processor, the memory being connected to the processor, the memory storing a control instruction, the processor is used for executing the control instruction so as to achieve the method for determining the insulin infusion dosage through the insulin infusion equipment. The method comprises the steps that historical blood glucose data and blood glucose monitoring data of a patient are obtained; acquiring a physiological metabolism model associated with the patient; according to the physiological metabolism model and the blood glucose monitoring data, physiological metabolism parameters corresponding to the patient are obtained; according to the physiological metabolism parameters and the historical blood glucose data, the infusion dosage of the insulin infusion equipment is determined. By adopting the scheme, the accuracy and rationality of the infusion dosage of the insulin infusion equipment can be improved.

Insulin pump for endocrine therapy

Nº publicación: CN223464302U 24/10/2025

Solicitante:

HUIZHOU SIXTH PEOPLES HOSPITAL
\u60E0\u5DDE\u5E02\u7B2C\u516D\u4EBA\u6C11\u533B\u9662

Resumen de: CN223464302U

The utility model provides an insulin pump for endocrine therapy, which comprises a bridle, the bridle is provided with an installation bag in a sliding manner, an insulin pump body is arranged in the installation bag, the bridle is also provided with a sliding belt, two ends of the sliding belt are fixedly connected with the bridle, the sliding belt is arranged in the installation bag in a penetrating manner, and the installation bag is provided with an insulin pump body. The installation bag is matched with the sliding belt in a sliding mode in the length direction of the sliding belt, and the binding belt is further provided with a fixing assembly used for fixing the binding belt to the body of a patient. The insulin pump has the advantages of being convenient to adjust the position of the insulin pump body and high in practicability.