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223
resultados
Última actualización
18/08/2026 [06:57:00]
Resultados 125 a 150 de 223
Resumen de: GB2702918A
The technology provides a system and method for assessing loss of vibration perception in a subject. It may be useful for the self-diagnosis, self-monitoring and self-treatment of adverse health conditions such as cutaneous neuropathy or diabetic foot, and for developing related prognoses. The system comprises a wearable or handheld vibration device 101 which includes piezoelectric 105,107 elements. These may be actuated to produce vibrations which are transmitted to the body surface of the subject by a probe. A communications apparatus is provided so that data can be transferred between the vibration device and a computing device such as a smartphone. The computing device is arranged to control levels of intensity of vibration of the piezoelectric elements 105,107, to record data representing levels of intensity of vibration, and to record and track input data entered by the user, corresponding to levels of intensity of vibration at which the subject perceives the transmitted vibrations via their body surface. With Figure 1
Resumen de: EP4769427A1
This application discloses a method and device for detecting an anomaly of a signal from a physiological parameter detection apparatus, particularly a continuous glucose monitor, CGM, comprising: acquiring a working parameter of the physiological parameter detection apparatus, wherein the working parameter comprises a working current; determining whether the signal from the physiological parameter detection apparatus is abnormal based on the working parameter: and outputting a detection result. Through the foregoing solution, an anomaly of a signal from the physiological parameter detection apparatus can be effectively detected, thereby ensuring signal accuracy.
Resumen de: EP4767931A1
The present application provides an analyte sensor based on blood glucose monitoring. The analyte sensor comprises a substrate, a working electrode, a reference electrode, a counter electrode, and a sensing layer; the sensing layer is provided on the working electrode; the working electrode, reference electrode, and counter electrode are provided at surfaces of the substrate, and the two electrodes from the working electrode; the working electrode, reference electrode, and counter electrode located at the same surface of the substrate are spatially separated by a channel. The analyte sensor can be implanted into a human body for monitoring, and has the characteristics of good flexibility, small size, low manufacturing cost, simple process flow, and long-term monitoring.
Resumen de: EP4767938A2
0001 The present disclosure relates to a continuous blood glucose measurement device and an applicator, wherein the continuous blood glucose measurement device is produced in a state in which a body attachment unit has been assembled inside an applicator, so as to minimize a user's additional work of attaching the body attachment unit to the body, thereby enabling the body attachment unit to be attached to the body only by simply activating the applicator. Particularly, the present invention provides a continuous blood glucose measurement device and an applicator, wherein the applicator comprises a plunger body disposed at a first locating in an inner space of a main case and configured to downwardly move to a second location according to a manipulation of a pressure button. The pressure button is configured to be mode-changeable from a first mode, in which pressurizing movement by pressurizing manipulation is prevented, to a second mode, in which the pressurizing movement by the pressurizing manipulation is allowed.
Resumen de: EP4769421A1
0001 The invention discloses a closed-loop artificial pancreas system for safe infusion, during a long period of real-time blood glucose value loss, the closed-loop artificial pancreas system can enter a learning mode or a safe mode. Based on historical blood glucose values and finger blood glucose values, it continues to calculate the required insulin infusion amount for the patient and infuses an appropriate amount of insulin to the patient. It will not infuse an inappropriate amount of insulin or even interrupt insulin infusion due to the lack of real-time blood glucose value, avoiding life-threatening situations for the patient and benefiting the patient's treatment.
Resumen de: EP4769422A1
An insulin pump control method and apparatus, an artificial pancreatic closed-loop system, and a storage medium are provided. The method includes: acquiring first monitoring data of a target object, obtaining an injection dosage of a first injection according to a target model and the first monitoring data, and injecting the target object based on the injection dosage of the first injection. The target model is adjusted based on total dosages corresponding to historical prediction failures.
Resumen de: EP4767933A1
0001 A method for controlling glucose in a flexibly structured dual-hormone artificial pancreas that manages optional meal and/or exercise notifications using coordinated control actions, which comprises: measuring a plasma glucose signal; calculating an incremental plasma glucose measurement (y); defining a model for incremental plasma glucose; defining a carbohydrate intake as dependent on a carbohydrate content estimated by the patient; defining an expected postprandial incremental plasma glucose y*(s) depending on the insulin bolus administered; defining a corrected incremental plasma glucose y(s), a corrected insulin infusion u(s), and a corrected carbohydrate d(s) intake; defining a virtual control action µ(s), divided into regulatory actions µr and counter-regulatory actions µcr and calculating control actions using a 2-DOF feedback controller with a nominal value pre-filter Fr(s).
Resumen de: CN122297923A
The invention relates to the technical field of flexible bioelectronics and skin attaching type phototherapy, and discloses a temperature and pressure sensing flexible phototherapy patch and system for diabetic foot ulcer, and the patch comprises a flexible phototherapy patch, a control module and a power supply module. The flexible phototherapy patch comprises an adhesion layer, a pressure sensing layer, a light emitting layer, a temperature sensing unit, a covering protection layer and a flexible interface. The pressure sensing layer is provided with a pressure sensing area and a light-transmitting area, and the light-emitting layer is arranged at the light-transmitting area or corresponds to the light-transmitting area, so that emitted red light and near-infrared light can penetrate through the covering protective layer to irradiate the corresponding area of the diabetic foot ulcer; the temperature sensing unit is arranged at a position adjacent to the light-emitting layer and is used for monitoring local temperature rise; the control module receives the pressure signal and the temperature signal, adjusts the phototherapy output parameter according to the pressure signal, and reduces the light emitting power or stops emitting light when the temperature exceeds a preset threshold value. The device has the attached temperature and pressure monitoring function, the dual-band phototherapy output function and the over-temperature automatic protection function, and is suitable f
Resumen de: CN224421641U
The utility model relates to the technical field of insulin injection, in particular to an insulin injection device with a rebound cover structure, which comprises an injection pen, a second threaded sleeve column arranged at the bottom of a first threaded sleeve column, a needle sleeved on the outer wall of the second threaded sleeve column, and a protective component sleeved on the outer wall of the first threaded sleeve column. A sliding groove communicated with the annular groove is formed in the outer wall of the base, a clamping groove is formed in the top of the sliding groove, and the rebound cover is matched with the annular groove in an inserted mode. According to the insulin injection device with the springback cover structure, the injection pen with an observation window is arranged, the content of injection liquid is observed in real time, a needle head is conveniently installed in a threaded mode under the cooperation of a first threaded column, a protection assembly is conveniently installed under the cooperation of a second threaded column, and the springback cover is matched with the base in an inserted connection mode under the cooperation of a spring; under the cooperation of the pull handle and the sliding groove, the springback cover is contained in the annular groove so that the injection pen can conduct injection conveniently, the springback cover protects the needle head when popping up, and the influence of the needle head on puncture injuries of medi
Resumen de: CN122303151A
The invention provides a method for improving the yield of total G sugar in gakanzumab, and particularly provides a method for culturing eukaryotic cells expressing the gakanzumab in a cell culture medium, and manganese ions and galactose are supplemented in the cell culture process, so that the yield of the total G sugar in the gakanzumab is improved, and the yield of the total G sugar in the gakanzumab is improved. The total G sugar level in the gakanzumab is effectively improved, so that an expected glycosylation spectrum is achieved.
Resumen de: CN122297830A
The present disclosure provides infusion devices for continuous glucose monitoring, particularly systems and devices for combining analyte monitoring with fluid delivery, including devices adapted for use with a combined sensor and a cannula with a sensor and a cannula on a single assembly. These systems and devices can be used in various applications for simultaneously monitoring analyte concentration and drug delivery in vivo.
Resumen de: US2022275340A1
The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of cells, wherein greater than 10% of the cells in the population express markers characteristic of single hormonal pancreatic beta cells.
Resumen de: CN224421648U
The utility model discloses an anti-stabbing insulin injection pen needle which comprises a supporting seat and a needle tube, a supporting cylinder is fixedly connected in the top of the supporting seat, a protective cylinder is movably inserted in the top of the supporting cylinder, a round hole is formed in the top of the protective cylinder, and a clamping groove is formed in the side wall of the protective cylinder, so that the protective cylinder ascends and descends linearly, and the stability is higher. When a clamping groove is aligned with a clamping rod in a clamping assembly, the clamping rod is clamped in the clamping groove under the pushing of the elastic force of a buffer spring, so that the protective barrel is conveniently stored in the supporting barrel, a needle tube is exposed out of a round hole, use is convenient, time and labor are saved, and after use is completed, the protective barrel can be conveniently stored in the supporting barrel. The pull handle is pulled to drive the pull rod, the pull rod drives the sliding plate to move, the sliding plate drives the clamping rod to be separated from the clamping groove, the protection barrel is pushed to reset under the springback effect of the supporting spring, the protection barrel covers the needle tube again, practicability is higher, and convenience and trouble saving are achieved.
Resumen de: CN122296876A
The invention discloses a glucose, cortisol, sodium ion and pH detection sensor and a preparation method, and belongs to the technical field of sensing detection, the glucose, cortisol, sodium ion and pH detection sensor comprises a substrate layer and a detection module arranged above the substrate layer, the detection module comprises a glucose detection module, a cortisol detection module, a sodium ion detection module and a pH detection module; and a bionic microfluidic unit and a bionic sweat diversion fabric layer. Through the glucose detection module, the cortisol detection module, the sodium ion detection module and the pH detection module, multi-parameter synchronous real-time detection of glucose, cortisol, sodium ion concentration and pH value in sweat is realized; meanwhile, the wettability gradient between the hydrophilic side and the hydrophobic side is constructed through the bionic sweat guide fabric layer, one-way moisture guide transmission of sweat from the skin side to the detection side is achieved, the collection efficiency of the sweat can be effectively improved, back seepage of the sweat is inhibited, and the detection accuracy of the concentration and pH of glucose, cortisol and sodium ions in the sweat is improved.
Resumen de: CN122272008A
The invention relates to an interface display method and system, a central station, a readable storage medium and a program product, and is applied to a blood glucose monitoring system.The method comprises the steps that in response to a multi-bed observation mode instruction input by a user, a display interface of the blood glucose monitoring system is controlled to display a plurality of display sections; after equipment binding operation of each display section, the blood glucose monitoring device and the insulin infusion equipment is completed, an information display area in the display section is controlled to display a blood glucose measured value collected during operation of the blood glucose monitoring device and insulin infusion information implemented during operation of the insulin infusion equipment; when it is monitored that at least one abnormal event occurs in the operation period of the blood glucose monitoring device and/or the insulin infusion equipment, alarm reminding information to be displayed is obtained according to an abnormal event alarm rule; and controlling an alarm display area in the display section to display the alarm reminding information. According to the method, management of different devices is integrated, so that the maintenance workload caused by dispersion of the devices and data is reduced.
Resumen de: CN122271947A
The invention provides underpants and a method for intelligently detecting and evaluating the risk of diabetes complicated with gynecological diseases, and relates to the field of diabetes complicated with disease detection. The invention discloses underpants for intelligently detecting and evaluating the risk of diabetes complicated with gynecological diseases. The underpants comprise an underpants body and a terminal, the crotch part of the underpants body is provided with a plurality of sensors for collecting the PH value of the vagina of a patient, the blood sugar of the patient, the content of secreta lactic acid bacteria and the content of secreta pathogenic bacteria, and a processor; the processor is used for analyzing the gynecological disease risk of the patient according to the vagina PH value of the patient, the blood sugar of the patient, the lactic acid bacteria content and the pathogenic bacterium content; and the terminal provides corresponding diagnosis and treatment suggestions according to the gynecological disease risk indexes of the patient. The method aims at the concurrent gynecological diseases caused by hyperglycemia of diabetic patients, so that the probability of occurrence of the concurrent gynecological diseases is reduced.
Resumen de: CN122291067A
The invention discloses an insulin pump dosage adjusting method, system and device and a storage medium, the insulin pump dosage adjusting method comprises the steps that an electronic health record, real-time blood glucose data and perioperative period stress index data of a target user are obtained, and the perioperative period stress index data comprise the operation type and anesthesia mode of the target user; inputting the electronic health record, the real-time blood glucose data and the perioperative period stress index data into the trained insulin pump dose prediction model to obtain an insulin dose prediction result output by the trained insulin dose prediction model; on the basis of the preset standard format, format conversion is performed on the insulin dose prediction result to obtain the standardized insulin dose prediction result, and the blood glucose management requirement of the user in the perioperative period is met.
Resumen de: CN122272298A
The invention relates to the technical field of urine sugar monitoring, in particular to an adult paper diaper urine sugar data monitoring method and system.The method comprises the steps that firstly, a nursing management system is interacted to obtain daily nursing nodes of a patient, and a wearable terminal is connected to generate a visual monitoring interface; secondly, collecting data by utilizing a plurality of groups of sensors integrated on the inner layer of the paper diaper at a preset node, and identifying the abnormality and predicting the blood glucose abnormality level in combination with the health parameters; then, a blood glucose fluctuation trend curve is generated in the interface based on the multi-node historical data. Finally, a personalized intervention scheme is formulated according to the abnormal level and the trend curve, and targeted nursing is implemented. According to the invention, non-invasive continuous monitoring is realized through multi-source signal fusion anti-interference; the blood sugar trend pre-judgment capability is achieved, and passive alarm is changed into active prevention; and through a visual interface and an intelligent decision closed loop, the nursing precision, efficiency and comfort of the diabetic patient are remarkably improved.
Resumen de: CN122278770A
The invention relates to a method for screening drugs for diseases closely related to unmarked G-protein coupled receptors (GPCR), in particular to an unmarked cell screening model of a GPR183 receptor and application of the unmarked cell screening model in preparation of drugs. And the unmarked cell screening model is a stably transfected cell strain CHO-K1-GPR183 with high expression of a GPR183 receptor. The GPR183 receptor stimulant compound N-demethylated nuciferine is obtained by screening through the GPR183 cell screening model established in the invention. At present, researches show that the GPR183 receptor is closely related to the occurrence and development of neuroinflammation/autoimmune diseases such as multiple sclerosis, colitis, type I diabetes and arthritis, cancers and metabolic diseases, so that a seedling compound can be provided for the development of medicines for related diseases.
Resumen de: CN122278758A
The invention provides a medicine for preventing and treating intrauterine adhesion and application thereof, and belongs to the technical field of biomedicine. The medicine comprises a pharmaceutically acceptable carrier and enhanced mesenchymal stem cells treated by a specific pretreatment culture medium. According to the pretreatment culture medium, stimulation components composed of notoginsenoside R1, melatonin and tartary buckwheat polypeptide are added into a basic culture medium. Through the remarkable synergistic effect of combined use of the three components, the endurance capacity of the mesenchymal stem cells to the hypoxia low-sugar damage microenvironment is effectively enhanced, and the paracrine function of the mesenchymal stem cells is enhanced. Experimental results show that the enhanced stem cell can significantly down-regulate fibrosis indexes such as alpha-SMA and COL1A1, inhibit the endometrial fibrosis process, significantly increase the thickness of the endometrium and the number of glands, promote structural reconstruction and functional repair of the damaged endometrium, and provide an efficient novel drug scheme for clinical treatment of intrauterine adhesion.
Resumen de: CN122278743A
The invention relates to the technical field of plant tissue culture, in particular to a culture medium for inhibiting browning of arenaria kansuensis explants and improving the induction rate of calluses and application of the culture medium. The invention provides a culture medium for inhibiting browning of arenaria kansuensis explants and improving the induction rate of calluses, which takes MS (Murashige and Skoog) as a basic culture medium and further comprises 2, 4-dichlorphenoxyacetic acid (2, 4-D), naphthylacetic acid (NAA), 6-furfurylaminopurine (KT), polyvinylpyrrolidone (PVP), cane sugar and agar, and the pH (Potential of Hydrogen) value of the culture medium is 5.83 to 5.85. Results of embodiments show that the culture medium provided by the invention can significantly improve the induction rate of the arenaria kansuensis callus. Furthermore, the callus obtained by the callus induction culture medium can be subjected to subculture to obtain a large amount of callus with loose texture and stable character, and a high-quality seed source is provided for industrial production of the arenaria kansuensis suspension cells.
Resumen de: CN224404116U
The utility model discloses an insulin needle anti-stabbing sleeve cover which comprises an insulin pen, an anti-stabbing sleeve cover mechanism is arranged at the bottom of the insulin pen, an insulin needle head is fixedly arranged in the anti-stabbing sleeve cover mechanism, and the anti-stabbing sleeve cover mechanism comprises an upper connecting part, a lower connecting part and a limiting sleeve. A sliding groove is formed in the limiting sleeve, a limiting groove is formed in the outer side of the sliding groove, a protection positioning mechanism is arranged in the limiting sleeve in a sliding mode, and the protection positioning mechanism comprises a puncture-proof sleeve connected to the interior of the limiting sleeve in a sliding mode; the anti-stabbing sleeve cover mechanism is stably installed at the bottom of the insulin pen through the threaded groove of the upper connecting part, the protective sleeve on the outer side of the limiting sleeve can prevent external objects from making contact with an insulin needle head when the insulin pen is not used, pollution and accidental stabbing are avoided, and safety in the insulin injection process is greatly improved; and the risk that the user is punctured and infected is reduced.
Resumen de: CN224404099U
The utility model relates to the technical field of insulin pump fixing, and discloses a dynamic insulin pump fixing support which comprises a machine body, a waistband is fixedly connected to the rear side of the machine body, shoulder straps are fixedly connected to the tops of the left end and the right end of the rear side of the waistband, and fixing buckles are fixedly connected to the tail ends of the two shoulder straps. The bottoms of the left sides and the right sides of the two fixing buckles are both slidably connected with buckles, the adjacent sides of the multiple buckles are both fixedly connected with springs, the middles of the adjacent sides of the multiple buckles are both fixedly connected with steel wires, the top ends of the two steel wires are both fixedly connected with sliding buckles, and a convenient adjusting mechanism is installed on the rear side of the waistband. According to the dynamic insulin pump fixing support, after the shoulder strap bypasses the shoulder, the fixing buckle is inserted into the upper groove of the waistband, at the moment, the spring pops up the buckle to fix the buckle, so that the waistband is prevented from sliding down during movement, the sliding buckle is pulled upwards to pull the buckle to retract through the steel wire, the fixing buckle is pulled out of the waistband, and then the dynamic insulin pump fixing support is taken down.
Resumen de: CN224403654U
The utility model discloses a blood glucose monitoring device which comprises a sensor carrier and an emission carrier, the sensor carrier comprises a first shell, a probe module and a sensor module, and the peripheral side of the first shell is provided with a first buckle and a second clamping groove located in the opposite side of the first buckle; the transmitting carrier comprises a fourth shell and a transmitting module, and a first clamping groove and a second clamping buckle are arranged on the peripheral side of the fourth shell. Wherein the first shell is respectively connected with the second shell and the third shell in a sealing manner through mucilage glue and the like, so that the sealing performance is enhanced, water, sweat and the like are prevented from entering the shells, the waterproof performance is improved, and the service life is prolonged. When assembling is needed, the launching carrier is obliquely pushed to enable the second buckle to be clamped into the second clamping groove, then the launching carrier is pressed downwards to enable the first buckle to be clamped into the first clamping groove, and at the moment, the blood glucose monitoring device is in a loaded state; when the blood glucose monitoring device needs to be disassembled, the first buckle is opened outwards, the first buckle is separated from the first clamping groove, the second buckle is separated from the second clamping groove, then the transmitting carrier is taken out, and a
Nº publicación: CN122278850A 26/06/2026
Solicitante:
AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV SCI & TECH
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Resumen de: CN122278850A
The invention relates to shRNA (short hairpin Ribonucleic Acid) for resisting diabetes-related heart failure, a recombinant expression vector, a transformant, a medicine, a method and pharmaceutical application thereof, and belongs to the field of biological medicines. The invention provides shRNA (short hairpin Ribonucleic Acid) for resisting diabetes-related heart failure. A corresponding DNA (Deoxyribose Nucleic Acid) sequence of the shRNA is selected from SEQ ID NO. 1. The invention also provides a recombinant expression vector based on the shRNA, a transformant, a medicine for resisting diabetes-related heart failure and pharmaceutical application of the shRNA, and provides a preparation method of the medicine for resisting diabetes-related heart failure. Animal experiments prove that the medicine for resisting the diabetes-related heart failure, provided by the invention, can be used for remarkably improving the heart function of an animal with the diabetes-related heart failure and plays an effective role in resisting the diabetes-related heart failure.
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