Alerta

一种多羟基可电离脂质、脂质纳米粒组合物与应用

Resumen de: CN122541324A

本发明涉及一种多羟基可电离脂质、脂质纳米粒组合物与应用。所述多羟基可电离脂质具有以下结构通式：；式中：R1选自取代或未取代的C10‑C30饱和烷基或不饱和烷基；R2选自取代或未取代的C2‑C15饱和烷基或不饱和烷基。与现有技术相比，本发明制得的多羟基可电离脂质及脂质纳米粒组合物可广泛应用于核酸递送载体、基因治疗药物及mRNA疫苗的制备。

一种氧缺陷二氧化钼基自组装靶向纳米平台及其制备方法和应用

Resumen de: CN122537323A

本申请提供了一种氧缺陷二氧化钼基自组装靶向纳米平台及其制备方法和应用。以表面带正电荷的氧缺陷二氧化钼纳米粒子为核心层，依次在核心层的表面包覆带负电的透明质酸层、带正电的聚赖氨酸层，形成具有核‑壳结构的MoO2@HA@PLL复合物。本发明不仅是简单地赋予氧缺陷二氧化钼以靶向和成像功能，更是要针对该特定材料的独特性质，克服从现有技术中无法直接获得启示的障碍，通过创新的组装顺序构建独特的结构（MoO2@HA@PLL），并实现一种更优的、不依赖酶激活的靶向摄取机制，最终获得一种性能卓越、机制先进的新型诊疗一体化纳米平台。

普鲁士蓝类似物纳米颗粒及其制备方法和应用

Resumen de: CN122537324A

本发明提出一种普鲁士蓝类似物纳米颗粒及其制备方法和应用，属于脑卒中领域及光催化技术领域。所述制备方法包括如下步骤：S1、采用共沉淀法，合成含有Cu、Ni、Co的具有S型异质结结构的Cu‑Ni Co PBAs纳米颗粒；S2、采用超声辅助吸附法，在Cu‑Ni Co PBAs纳米颗粒表面采用PLGA‑PEG‑CREKA修饰肽进行包裹，得Cu‑Ni Co PBAs‑C材料。本发明提出的添加生物修饰肽的普鲁士蓝类似物纳米材料(Cu‑Ni Co PBAs‑C)，通过其光催化产氢，用于缺血性脑卒中的治疗，以改善传统氢气治疗方法的弊端。

筋肉特異的送達のためのイオン化可能な脂質

Resumen de: AU2024303863A1

The present invention provides an ionizable lipid for muscle-specific delivery, and specifically relates to a compound of formula (I), or an isotopic variant, tautomer or stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention further provides a nanoparticle pharmaceutical composition comprising the compound, and a use of the compound and the composition thereof in muscle-specific nucleic acid delivery.

An artificial exosome for drug delivery and a preparation method thereof

Resumen de: NL4002163A

The invention relates to the technical field of medicine, and discloses an artificial exosome for drug delivery and a preparation method thereof. The invention uses PCL- PEG-PCL, DC-Chol, and TA-PEG-TA to construct a polymer core, loads OCT4 protein, siTrim28, and VC-Lip, forms a suspension through high-pressure-ultrasonic synergistic treatment and solvent evaporation curing, and then obtains the final product through dynamic film formation, multilayer self-assembly coating, gradient centrifugation purification, and hyaluronic acid anti-enzymatic degradation modification. The invention is significantly superior to artificial exosomes prepared by the prior art in four core indicators, namely structural stability, intelligent responsive release, targeting specificity, and anti-destruction capability.

方法およびシステム

Resumen de: WO2025032322A1

A method of generating a plurality of different surface-decorated nanoparticles, decorated with different surface decoration, comprising: forming a plurality of microdroplets in a microfluidics device, each microdroplet comprising a nanoparticle and a respectively different macromolecule encoding a different surface decoration molecule; synthesising the surface decoration molecule, within each microdroplet, based on the macromolecule encoding the surface decoration molecule; conjugating the nanoparticle and the surface decoration molecule, within each microdroplet, to form surface decorated nanoparticles.

親油性化合物を含む水性メソ粒子組成物の新規な製造方法

Resumen de: NL2035231B1

Described is a method for the preparation of an aqueous nanoparticle composition comprising a hydrophobic compound, comprising the steps of: a. Providing an emulsifier or a blend of emulsifiers in powder form; 10 b. Mixing one or more oils at a temperature above 40°C where all oils have become liquid, wherein said oils differ in melting temperature and which mixture comprises at least a sufficient amount of medium chain triglycerides to enable the composition formed in step g to be liquid at temperatures around about 4°C; 15 c. Adding the hydrophobic compound in any hydrophobic solvent to the oil mixture; d. Optionally letting the mixture cool down to room temperature; e. Adding the emulsifier powder and water to the oil mixture and letting the mixture emulsify, under optional agitation and heating to 30-40°C; 20 f. Subjecting the emulsified mixture to a sonication treatment comprising optionally mixing or fluidisation, until the average particle size of the mixture remains stable; g. Cooling down the sonicated mixture. and compositions produced by the above method. 25

経皮免疫療法のための方法およびシステム

Resumen de: WO2025024500A1

Disclosed herein are patches, methods, devices, and systems for delivering RNA encapsulated lipid nanoparticles into a subject. In some aspect, the patch includes a backing, a reservoir comprising lipid nanoparticles and one or more RNA molecules disposed within the reservoir, and a release liner. In other aspects, the method includes opening at least one channel in the subject's skin, applying the patch described herein, thereby delivering lipid nanoparticles to an immune cell.

ジエステル脂質、ジエステル脂質を含有する脂質ナノ粒子、及びそれらの製剤

Resumen de: WO2025010504A1

Provided is a diester lipid compound of Formula (I) or a pharmaceutically acceptable salt thereof The compound can be used to obtain lipid nanoparticles. In some embodiments, the lipid nanoparticle can comprise (a) from about 40 to about 100 mol % of the compound of Formula (I); (b) from 0 to about 10 mol % of a neutral lipid; (c) from 0 to about 50 mol % of a helper lipid; (d) from 0 to about 5 mol % of a polymer-conjugated lipid; and (e) from 0 to about 5 mol % of a hydrophobic component; wherein the mol % are based on the total lipids present in the nanoparticle. (I)

乾燥及び長期保存用ポリヌクレオチド製剤の組成物、方法及び使用

Resumen de: WO2025029323A1

Embodiments of the present disclosure provide novel compositions and methods for making and using thermostable polynucleotide-containing formulations. In certain embodiments, compositions and methods are disclosed for creating thermostable polynucleotides and/or thermostable polynucleotides encoding at least one therapeutic agent for use in therapies for the treatment of health conditions in a subject. In some embodiments, compositions and methods are disclosed for creating thermostable polynucleotides for use in therapeutics, vaccines, and targeted gene therapies. In other embodiments, compositions and methods are disclosed for creating thermostable polynucleotides capable of being coated or encased for prolonged storage and/or timed-delivery.

聚乙二醇化脂质

Resumen de: WO2025106806A1

Compounds are provided having the following Formula (I): (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein R1, R2, R3, m, and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

脂質および脂質ナノ粒子

Resumen de: TW202517607A

Disclosed is an ionizable lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof), and compositions comprising such lipids useful for the delivery of biologically active agents.

经修饰的小细胞外囊泡及其用途

Resumen de: WO2025101988A1

Small extracellular vesicles (sEVs) are provided herein containing at least one tetraspanin that has at least one noncanonical amino acid (ncAA) substituting for a native amino acid in an extra-exosomal loop. The tetraspanin can be CD81, and the ncAA can contain an azide group, a carboxyl group, or a strained alkene. The sEV can further include a peptide that decreases the elimination of sEV by macrophages, a peptide that steers the sEV to a target tissue, and/or a peptide that decreases the rate of degradation of the sEV by target cell lysosomes, each attached to a ncAA. The sEV can further include a poly-histidine tag and/or cargo. The associated compositions, plasmids, cell lines, and animals, methods of producing the sEVs, and methods of treating a disease using the sEV or sEV compositions are also provided.

一种用于胃肠道靶向治疗的光热响应型磁性软体机器人及其制备方法和应用

Resumen de: CN122516132A

一种用于胃肠道靶向治疗的光热响应型磁性软体机器人及其制备方法和应用，用于实现一种集抗酸保护、磁驱动导航与光热触发释药功能于一体的口服给药系统。核心在于提供一种球形核壳结构的软体机器人，其内核由四氧化三铁纳米颗粒（Fe3O4）及包覆其上的聚多巴胺（PDA）层构成，PDA层上负载有治疗药物（如抗生素CIP）；外壳则为海藻酸钙水凝胶。该结构使机器人能耐受胃酸，保护药物活性。该机器人可在三维亥姆霍兹线圈系统中通过多轴交变磁场进行精确运动控制：利用Fe3O4@PDA的光热效应使局部升温，等到恢复至体温，再次照射，重复操作几次，导致海藻酸钙外壳溶胀降解，从而实现药物的定点、快速释放。

一种负载siRNA的纳米复合物在治疗胰腺外分泌功能不全中的应用

Resumen de: CN122516138A

本发明涉及生物医药领域，具体是一种负载siRNA的纳米复合物在治疗胰腺外分泌功能不全中的应用，所述的负载siRNA的纳米复合物是将RRM2 siRNA与金纳米簇AuNCs复合后，再载入间充质干细胞来源的外泌体MSC‑EVs，最终制备出所述的纳米复合物AuNC‑siRNA/EV。本发明的纳米复合物可恢复胰腺外分泌功能，有效缓解胰腺外分泌功能的持续性炎症损伤，为胰腺癌术后胰腺外分泌功能不全提供了新的治疗药物。

一种靶向衰老细胞的多模态纳米递送系统、制备方法及应用

Resumen de: CN122516135A

本申请涉及一种靶向衰老细胞的多模态纳米递送系统、制备方法及应用，涉及生物医药和纳米技术领域。该系统包括选自脂质纳米颗粒、脂质体或聚合物胶束的纳米载体核心，表面共价修饰的由抗 uPAR scFv 与抗 MICA/B scFv 组成的双靶向配体组合，以及封装于核心内的通过腙键连接的 Dasatinib‑SBB‑pH 偶联物；该系统在酸性微环境下发生内涵体逃逸并触发腙键断裂释放药物，使游离药物在线粒体区域富集。本申请可以有效解决现有 Senolytics 药物缺乏衰老细胞特异性、脱靶毒性高及药物释放不可控的问题，显著提高对衰老细胞的清除效率并降低副作用。

一种精浆胞外囊泡-脂质纳米杂化颗粒及其制备方法、药物组合和子宫内膜局部应用

Resumen de: CN122516139A

本公开提供一种精浆胞外囊泡‑脂质纳米杂化颗粒及其制备方法、药物组合和子宫内膜局部应用。方法包括：制备脂质纳米颗粒；从人源精浆中分离精浆胞外囊泡（sEV），并经密度梯度离心纯化获得高密度组分精浆胞外囊泡（sEV‑Hs）；将高密度组分精浆胞外囊泡与脂质纳米颗粒混合，并通过冻融循环实现高密度组分精浆胞外囊泡与脂质纳米颗粒的杂化融合。本公开的杂化纳米颗粒同时保留了胞外囊泡的天然膜蛋白组分与LNP的pH响应性自组装功能，在赋予载体细胞识别能力与组织特异性靶向性的同时，保障了mRNA的胞内高效释放，实现了两类载体核心优势的协同叠加。

治疗脓毒症、动脉粥样硬化、血栓形成、中风、心脏病发作和炎症的肽和方法

Resumen de: US2022347113A1

The present disclosure provides peptides that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, particularly nanoparticle compositions, comprising the same and to methods of using the peptides to treat atherosclerosis, thrombosis, stroke, heart attack, inflammation, acute respiratory distress syndrome (ARDS), autoimmune diseases, AV Fistula for hemodialysis or organ transplantation.

一种通过多级程序性释放与肠道靶向递送技术制备的复合降糖功能因子及其工艺

Resumen de: CN122516113A

本发明涉及生物药品制造领域，公开了一种通过多级程序性释放与肠道靶向递送技术制备的复合降糖功能因子及其工艺，解决现有宠物糖尿病管理中血糖波动大及机体机能衰退的综合性治疗难题。本发明通过构建内层壳聚糖载药纳米核心与外层海藻酸钠、β‑葡聚糖互穿网络基质，经微流控交联与冷冻干燥制得核壳结构微球。本发明实现了胃部耐酸保护、肠腔物理阻隔、粘膜靶向修复的多级程序性释放，利用外层pH响应性释放β‑葡聚糖构建控糖屏障，内层纳米团簇靶向粘附肠粘膜深度缓释人参皂苷及微量元素。该方案有效解决了活性成分失活与吸收难题，协同实现了物理控糖与机能修复，显著提升了生物利用率。

一种基于铜绿假单胞菌细菌外膜囊泡的化疗-免疫联合抗肿瘤递送系统及其制备方法和应用

Resumen de: CN122516136A

本申请提出一种基于铜绿假单胞菌细菌外膜囊泡的化疗‑免疫联合抗肿瘤递送系统及其制备方法和应用；通过硫酸铵处理，使用被动孵育方式的方式将具有抗肿瘤药物负载于细菌外膜囊泡内；细菌外膜囊泡具有较好的生物相容性、黏膜穿透能力并具有免疫刺激能力；而抗肿瘤药物包埋在细菌外膜囊泡内，能够被保护和缓慢释放，延长药物在膀胱内的滞留时间，增强对肿瘤组织的杀伤。因此本申请通过细菌外膜囊泡和抗肿瘤药物构建了化疗‑免疫联合机制抗肿瘤递送系统，实现化疗与免疫治疗的协同抗肿瘤效果。

一种恩杂鲁胺耐药前列腺癌的分子标志物及其靶向治疗应用

Resumen de: CN122521849A

本发明涉及一种恩杂鲁胺耐药前列腺癌的分子标志物及其靶向治疗应用，属于肿瘤治疗技术领域。本发明提供了一种恩杂鲁胺耐药前列腺癌的分子标志物，其核苷酸序列如SEQ ID NO：6所示。本发明通过体内CRISPR‑Cas9筛选文库发现，在恩杂鲁胺处理组中酮糖‑5‑磷酸‑3‑差向异构酶(RPE)基因位于显著候选基因之首。实验证明，在恩杂鲁胺环境下，敲低RPE基因后前列腺癌细胞对恩杂鲁胺的敏感性增强，活力显著下降。这说明敲低RPE基因可显著抑制前列腺癌细胞在恩杂鲁胺环境下的克隆形成能力以及长期增殖能力。因此，本发明发现RPE基因可以作为恩杂鲁胺耐药前列腺癌的分子标志物。

一种天然多糖-桦木酸偶联物及其制备方法与应用

Resumen de: CN122516376A

本发明公开了一种天然多糖‑桦木酸偶联物及其制备方法与应用，通过亲水性天然多糖侧链的羟基与疏水的桦木酸的羧基反应，将桦木酸键合到亲水性天然多糖的侧链，得到两亲性的天然多糖‑桦木酸偶联物。本发明的天然多糖‑桦木酸偶联物可在水溶液中自组装形成纳米粒子，并可以用于包载疏水的抗癌药物，改善了疏水的桦木酸和抗癌药物的溶解性，此外，形成的纳米粒子粒径小于300 nm，在体内循环过程中可避免被内皮网状系统清除，进而延长桦木酸及包载的抗癌药物在体内的循环时间，提高其生物利用度。

一种脑靶向脐带间充质干细胞外泌体及其应用

Resumen de: CN122516131A

本发明涉及一种脑靶向脐带间充质干细胞外泌体及其应用。本发明通过大量研究，提供了一种脑靶向RVG肽修饰的脐带间充质干细胞外泌体（EVs‑RVG‑miR‑544‑5p）的构建方法，以及在肿瘤相关抑郁小鼠模型中的靶向性与疗效验证，该方法能够高效、稳定地产出高纯度的脑靶向外泌体EVs‑RVG‑miR‑544‑5p。本发明的EVs‑RVG‑miR‑544‑5p克服了传统外泌体脑靶向效率低、脱靶效应明显的瓶颈，其能够有效穿过血脑屏障，递送miR‑544‑5p至脑区并减少小胶质细胞过渡激活，缓解抑郁症状。该外泌体具有优异的递送特征，为肿瘤相关抑郁的精准治疗提供了全新的药物研发、临床治疗方向，同时也为其他中枢神经系统疾病的靶向治疗提供了可借鉴的技术路径，具有极高的社会价值和市场应用前景。

一种HA修饰的姜黄素与prNK-lysin自组装纳米颗粒及其制备方法与应用

Resumen de: CN122516338A

本发明公开了一种HA修饰的姜黄素与prNK‑lysin自组装纳米颗粒及其制备方法与应用，属于临床兽医学与中药现代化技术领域。本发明利用姜黄素和prNK‑lysin自组装成纳米颗粒（prNK‑lysin‑Cur NPs），再用透明质酸修饰其表面，形成prNK‑lysin‑Cur @HA NPs。此纳米颗粒在表面修饰透明质酸后，通过静脉注射后，可靶向犬乳腺肿瘤从而实现精准给药；且能够有效的抑制原位犬乳腺肿瘤的转移；在通过药物的自组装后，能有效防止prNK‑lysin在体内的降解和解决姜黄素生物利用度极低的问题。

酸响应自锚定纳米药物递送系统、制备方法及其应用

Nº publicación: CN122516133A 07/08/2026

Solicitante:

南通大学附属医院

Resumen de: CN122516133A

本申请提供了一种酸响应自锚定纳米药物递送系统、制备方法及其应用，涉及药物载体技术领域，其中，所述酸响应自锚定纳米药物递送系统以介孔聚多巴胺作为核心，在所述介孔聚多巴胺的表面包覆有酸响应矿化物保护层以及负载于介孔聚多巴胺中的活性成分。本发明利用酸响应矿化物层在肿瘤微环境中的分解特性，同步释放钙离子和过氧化氢，驱动聚多巴胺核心发生自聚集并介导其在细胞界面锚定，实现药物的高效富集与长效滞留。随后，负载的基质降解酶缓慢释放，通过正反馈模式持续重塑致密基质，促进药物深部渗透，进而缓解乏氧、逆转免疫抑制微环境，增强肿瘤化学免疫治疗。本发明为基质丰富型肿瘤（如肺癌）提供了一种高效、低毒的靶向治疗新策略。