Alerta

pH敏感性阳离子性脂质、脂质纳米粒子、含有脂质纳米粒子的医药用组合物以及脂质纳米粒子的用途

Resumen de: US2024024252A1

The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4).(R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I)(R11)(R12)—CH—(CO—O)c—(CH2)v-  (A)—(CH2)d—N(R3)(R4)  (B)

用于治疗动脉粥样硬化的复合纳米粒子及其制备方法和应用

Resumen de: CN121695107A

本发明属于生物医药和纳米材料技术领域，具体涉及一种用于治疗动脉粥样硬化的复合纳米粒子及其制备方法和应用。本发明所述复合纳米粒子以聚多巴胺纳米粒子为核心载体，负载有金纳米粒子和普罗布考，最外层由红细胞膜囊泡包覆。本发明利用聚多巴胺纳米粒子的活性氧清除能力、金纳米粒子的类酶催化活性、普罗布考的降脂抗炎作用，以及红细胞膜的免疫逃逸和病灶靶向功能，产生了协同增强的治疗效果。所述复合纳米粒子生物相容性好，靶向性强，能高效富集于动脉粥样硬化斑块处，显著提升治疗效果并降低副作用，在制备动脉粥样硬化治疗药物中具有广阔应用前景。

PTN在制备治疗严重感染导致的认知障碍的产品中的应用

Nº publicación: CN121695284A 20/03/2026

Solicitante:

中国医学科学院基础医学研究所

Resumen de: CN121695284A

本发明公开PTN在制备治疗严重感染导致的认知障碍的产品中的应用。本发明提供的PTN的抑制剂能够抑制慢性神经炎症，从而预防和抑制严重感染导致的晚期认知障碍形成和发展，同时抑制PTN的表达或功能能够有效阻断浸润性巨噬细胞对小胶质细胞的损害，为相关疾病的治疗提供了新的方向。