Alerta

用于治疗癌症的组合物和方法

Resumen de: AU2023343598A1

Compounds, compositions, uses, and methods for reducing cell viability of a cancer cell, or for preventing or treating cancer, are provided herein. In certain examples, methods for reducing cell viability of a cancer cell and/or for preventing or treating cancer in a subject in need thereof are provided which may include a step of treatment with a GDP-bound form of Rab1a (Rab1a

一种具有免疫调节和抑制肝癌细胞的负载阿霉素的人参硒多糖纳米载体的制备方法

Resumen de: CN120078742A

本发明公开了一种具有免疫调节和抑制肝癌细胞的负载阿霉素的人参硒多糖纳米载体的制备方法，要解决抗肿瘤药物阿霉素导致组织和器官的毒性损伤以及存在免疫系统的抑制的问题。本发明通过将脱氧胆酸接枝在人参硒多糖上，使其疏水化并形成两亲性多糖聚合物，克服了人参硒多糖分子量大和生物利用度低等局限性。以自组装人参硒多糖纳米粒为抗肿瘤药物递送的载体，不仅具有免疫调节作用能有效改善抗肿瘤药物引起的免疫抑制等副作用；还具备pH敏感响应释放特性，从而增强药物在肿瘤区域的靶向效果，这一创新性载体具备良好的临床应用前景。

ナノ構造体、ナノ複合体及びそれらの実装

Resumen de: AU2023255525A1

The present disclosure relates to a nanostructure comprising: 50 to 80% (w/w) of a magnetic material; and 20 to 50% (w/w) of calcium silicate. The present disclosure 5 further relates to a nanocomposite comprising the nanostructure as disclosed herein with an additive. The present disclosure also provides a gel comprising the nanostructure or the nanocomposite and additives, and methods thereof.

多重エピトープ構築物

Resumen de: CN119255818A

The invention relates to the field of vaccination therapy. More specifically, the present invention relates to a multi-epitope construct comprising a nucleic acid sequence encoding a peptide derived from a coronavirus or a functional variant thereof and a fragment thereof. The invention also relates to combinations, polypeptides or pharmaceutical compositions for use in the treatment or prevention of coronavirus in a subject; in particular, SARS-CoV-2 virus.

アンジオポエチン関連タンパク質７特異的抗体及びその使用

Resumen de: MX2024013138A

The present disclosure relates to the treatment and/or prevention of glaucoma and other diseases affecting the optic nerve and retinal ganglion cells. In particular, the present disclosure provides novel therapeutic antibodies, and related compositions and methods, that target angiopoietin-related protein 7 (ANGPTL7) to reduce intraocular pressure (IOP) in order to prevent optic nerve damage and restore vision.

一种用于肿瘤免疫治疗的巨噬细胞特异性RNA编辑的聚合物纳米系统

Resumen de: CN120082029A

本发明涉及肿瘤免疫治疗领域，尤其涉及一种用于巨噬细胞特异性RNA编辑的纳米聚合物系统及其应用。该系统能够通过靶向巨噬细胞上的吞噬检查点，通过RNA编辑增强肿瘤相关巨噬细胞的吞噬功能，并在体内调节抗肿瘤免疫反应。我们还证明了该MAGE系统在多种小鼠肿瘤模型(包括基于人源患者肿瘤异种移植的胰腺腺癌模型)中的治疗效果。为体内递送RNA编辑工具至巨噬细胞提供了一个有前景的平台。

一种AMD3100固核脂质纳米粒及其应用

Resumen de: CN120078735A

本发明公开了一种AMD3100固核脂质纳米粒及其应用。本发明提供了一种固核脂质纳米粒，其包括DOPA改性的磷酸钙内核、DSPE‑PEG2000‑AMD3100、DSPE‑PEG2000、胆固醇和DOTAP；所述DSPE‑PEG2000‑AMD3100的结构如式I所示；所述DOPA改性的磷酸钙内核中，所述DOPA负载于所述磷酸钙内核表面。本发明将AMD3100作为递药载体的靶头修饰于固核脂质纳米粒载体上，有助于将大量的治疗性药物递送至缺血区域的受损细胞及新生细胞，实现缺血脑区的靶向药物递送，提高药物治疗效果。#imgabs0#

エプスタイン－バーウイルスワクチン

Resumen de: JP2023171398A

To provide EBV ribonucleic acid vaccines as well as methods of using the vaccines and compositions comprising the vaccines.SOLUTION: Provided herein, in some embodiments, are Epstein-Barr virus (EBV) ribonucleic acid (RNA) (e.g., mRNA) vaccines (e.g., combination vaccines) that elicit potent neutralizing antibodies and robust T cell responses, inhibit the production of viral immunomodulatory factors, and/or prevent viral latency.SELECTED DRAWING: None

自己組織化ペプチドナノ粒子およびその使用

Resumen de: US2022088221A1

Disclosed are self-assembling nanoparticle compositions that comprise a plurality of cationic cell penetrating peptides, each covalently linked to a hydrophobic therapeutic molecule (e.g., an antigenic peptide, mRNA, siRNA, DNA, or the like), and optionally, non-covalently bound to at least one TLR (Toll-like receptor) ligand. Also disclosed are methods for use of the nanoparticle compositions in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of a mammalian disease, including, without limitation, cancer, infection, inflammation, and related diseases and abnormal conditions.

治療用ナノ粒子を合成するための方法及び組成物

Resumen de: CN119638713A

Methods and compositions for the synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymer core, wherein one or more directing molecules and one or more therapeutic agents are attached to the polymer core. Improvements in speed, yield and purity are achieved using the methods disclosed herein.

タンパク質抗原およびその使用

Resumen de: CN118370809A

The invention relates to protein antigens and uses thereof. The field of the invention relates to immunotherapeutic peptides, peptide binding agents and their use, for example, in the immunotherapy of cancer.

一种脑靶向APP@Dextran-Fe3O4纳米颗粒及其制备方法和应用

Resumen de: CN120078915A

本发明属于医学成像技术领域，具体涉及一种脑靶向APP@Dextran‑Fe3O4纳米颗粒及其制备方法和应用。本发明所提供的APP@Dextran‑Fe3O4纳米颗粒可通过非侵袭的静脉注射方式作用于脑内的β淀粉样蛋白受体，从而实现跨血脑屏障转运，并且在阿尔茨海默病患者的脑内具有更高的积累作用，尤其是在阿尔茨海默病主要的病变部位海马处异常累积，结合MPI成像高分辨率、高灵敏度的特点可实现阿尔茨海默病的诊断。同时病理分析发现APP@Dextran‑Fe3O4纳米颗粒具有抑制阿尔茨海默病脑内炎症反应，减少神经元细胞凋亡作用，对减缓阿尔茨海默病具有一定的益处。

Rna molecules encoding rsv-f and vaccines containing them

Resumen de: AU2023369585A1

The present disclosure relates to RNA molecules encoding a respiratory syncytial virus (RSV). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the treatment and/or prevention of RSV infection-induced acute respiratory tract illness, including pneumonia and bronchitis.

Polyoxyalkylene-1,2-dimyristoyl-glycerol compounds, wherein the polyoxyalkylene is a poly(ethylene oxide) having c1 to c3-alkyloxymethyl side chains

Resumen de: WO2024105071A1

The present invention refers to novel polyoxyalkylene based compounds and their manufacturing method as well as compositions comprising at least one novel polyoxyalkylene based compound and at least one active agent. Furthermore, the present invention refers to the manufacture of the compositions of the present invention as well as their use for the treatment of an illness in mammals or humans.

Novel ionizable lipids

Resumen de: AU2023361218A1

The present invention relates to compounds of formula (I). The invention also extends to micro- or nanoparticles comprising a compound of formula (I). For instance, compounds of formula (I) can be used to produce stable lipid nanoparticles (LNPs). The LNPs have high encapsulation efficiency and can be used to deliver a therapeuticor prophylactic agent to a patient.

Method for treating osteoarthritis with a combination of mesenchymal stem cell exosomes, synovial mesencymal stem cells, and scaffolds

Resumen de: MX2021009485A

Disclosed herein are methods for treating osteoarthritis may be a one-step arthroscopic procedure and may include detaching synovial mesenchymal stem cells (MSCs) from the synovium using a brush device; covering articular cartilage in an affected joint with a scaffold; and placing concentrated MSC exosomes into the affected joint to stimulate differentiation of synovial MSCs into articular cartilage cells.

Self-assembling nanoparticles

Nº publicación: IL320235A 01/06/2025

Solicitante:

BARINTHUS BIOTHERAPEUTICS NORTH AMERICA INC [US]
THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]
BARINTHUS BIOTHERAPEUTICS NORTH AMERICA INC,
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Resumen de: AU2023367780A1

The present disclosure relates to a vaccine comprising at least one peptide antigen conjugate having the formula selected from PEG-E1-A-E2-U-H and H-U-E1-A-E2-PEG, wherein E1 is an N terminal extension, E2 is a C terminal extension, A is peptide antigen, H is hydrobhobic block, wherein one or more drug molecules (D) are optionally attached to each H directly or via a suitable linker X1; U is a linker, denotes the group is optional and - denotes that the two adjacent groups are directly attached to one another by a covalent bond or indirectly to one another via a suitable linker X. The vaccine is useful in treating or preventing a cancer, an autoimmune disease, an allergy, or an infectious disease.