Ministerio de Industria, Turismo y Comercio LogoMinisterior
 

Alerta

Resultados 244 resultados
LastUpdate Última actualización 17/04/2026 [07:22:00]
pdfxls
Solicitudes publicadas en los últimos 60 días / Applications published in the last 60 days
previousPage Resultados 125 a 150 de 244 nextPage  

神经颗粒蛋白在诊断和治疗脊髓小脑性共济失调3型中的应用

NºPublicación:  CN121629038A 10/03/2026
Solicitante: 
中南大学湘雅医院
CN_121629038_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种放大信号的全自动免疫检测方法、检测试剂及样本分析仪

NºPublicación:  CN121633467A 10/03/2026
Solicitante: 
深圳市新产业生物医学工程股份有限公司
CN_121633467_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

样本稀释液及其制备方法、应用和产品

NºPublicación:  CN121632727A 10/03/2026
Solicitante: 
中南大学湘雅三医院广州市微米生物科技有限公司
CN_121632727_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Amyloid- oligomer specific fluorescent probe compound

NºPublicación:  KR20260033275A 10/03/2026
Solicitante: 
고려대학교산학협력단조선대학교산학협력단연세대학교산학협력단
KR_20260033275_PA

Resumen de: KR20260033275A

본 발명은 하기 화학식 1로 표시되는 형광 프로브 화합물에 관한 것이다: 화학식 1 JPEGpat00013.jpg4999.

结合人微管相关蛋白tau不同异构体的单克隆抗体配对及应用

NºPublicación:  CN121627878A 10/03/2026
Solicitante: 
杭州华抗生物技术有限公司
CN_121627878_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

단백질-단백질 상호작용을 유도하는 화합물을 식별하는 방법

NºPublicación:  KR20260034056A 10/03/2026
Solicitante: 
온코피아테라퓨틱스인코퍼레이티드디비에이에스케이라이프사이언스랩스
KR_20260034056_PA

Resumen de: WO2024263939A1

The present disclosure relates method of identifying a compound targeting a first protein and a second protein, wherein the first protein and/or the second protein are associated with a disease or disorder.

Fos Composition for inhibiting Fos transcription factor comprising as an active ingredient an extract of Jakyakgamchotang or a compound derived from the extract of Jakyakgamchotang

NºPublicación:  KR20260030219A 06/03/2026
Solicitante: 
한국한의학연구원
KR_20260030219_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种黏度响应型荧光探针、制备方法及其应用

NºPublicación:  CN121609669A 06/03/2026
Solicitante: 
陕西省人民医院(陕西省临床医学研究院)
CN_121609669_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种超敏阿尔茨海默症血液诊断试剂盒及其检测方法

NºPublicación:  CN121613109A 06/03/2026
Solicitante: 
浙江欧赛思生物科技有限公司
CN_121613109_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

阿尔茨海默病的诊断和治疗方法

NºPublicación:  CN121620700A 06/03/2026
Solicitante: 
分子优公司
CN_121620700_PA

Resumen de: AU2024276342A1

Provided herein is a method for diagnosing and treating Alzheimer's disease comprising: (a) providing a biological sample obtained from the subject; (b) measuring concentration levels from the obtained sample, at least one, at least two, at least three, at least four or at least five Alzheimer's-related metabolites described herein and/or at least one, at least two, at least three, at least four or at least five Alzheimer's-related proteins described herein; (c) comparing the concentration levels of the Alzheimer's-related metabolites and/or proteins from the obtained sample to the concentration levels of corresponding reference Alzheimer's-related metabolites and/or proteins from an Alzheimer's- negative sample; (d) identifying the subject as having Alzheimer's if the concentration levels of the Alzheimer's-related metabolites and/or proteins from the obtained sample are different relative to the concentration levels of the reference Alzheimer's-related metabolites and/or proteins from the Alzheimer's-negative sample; and (e) treating or causing treatment of the subject.

β-连环蛋白贮库检测和调节测定

NºPublicación:  CN121620701A 06/03/2026
Solicitante: 
露点治疗公司
CN_121620701_PA

Resumen de: US2018099049A1

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

制御性T細胞表面抗原のエピトープおよびこれに特異的に結合する抗体

NºPublicación:  JP2026507922A 06/03/2026
Solicitante: 
グッドティーセルズ、インコーポレイテッド
JP_2026507922_PA

Resumen de: WO2024263939A1

The present disclosure relates method of identifying a compound targeting a first protein and a second protein, wherein the first protein and/or the second protein are associated with a disease or disorder.

COMPOSITION FOR MICROGLIAL REJUVENATION

NºPublicación:  WO2026049217A1 05/03/2026
Solicitante: 
UNIV CHA IND ACAD COOP FOUND [KR]
SUNGKWANG MEDICAL FOUND [KR]
\uCC28\uC758\uACFC\uD559\uB300\uD559\uAD50 \uC0B0\uD559\uD611\uB825\uB2E8
\uC758\uB8CC\uBC95\uC778 \uC131\uAD11\uC758\uB8CC\uC7AC\uB2E8
WO_2026049217_PA

Resumen de: WO2026049217A1

A composition for microglial rejuvenation according to an aspect, in which the composition comprises, as an active ingredient, an expression of an ACE protein or a gene inhibitor encoding same, rejuvenates microglia rather than suppresses neuroinflammatory responses in order to treat, prevent, or alleviate brain aging-related diseases. Accordingly, the composition is expected to be widely used in the treatment of most brain aging-related diseases for which existing neuroinflammatory response suppression strategies have failed.

METHODS AND ASSAYS FOR MODULATING GENE TRANSCRIPTION BY MODULATING CONDENSATES

NºPublicación:  KR20260030170A 05/03/2026
Solicitante: 
화이트헤드인스티튜트포바이오메디칼리서치메사추세츠인스티튜트오브테크놀로지
KR_20260030170_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Methods for Assaying a Bodily Sample of a Subject

NºPublicación:  US20260063642A1 05/03/2026
Solicitante: 
AGENT S A S [FR]
US_20260063642_PA

Resumen de: US20260063642A1

0000 In an aspect, the present disclosure provides a method comprising: (a) obtaining a bodily sample from a subject; and (b) assaying the bodily sample to determine a level of analytes in the sample, wherein the analytes comprise nucleic acids, proteins, or metabolites.

Biomarkers For A Systemic Lupus Erythematosus (SLE) Disease Activity Immune Index That Characterizes Disease Activity

NºPublicación:  US20260063632A1 05/03/2026
Solicitante: 
OKLAHOMA MED RES FOUND [US]
US_20260063632_PA

Resumen de: US20260063632A1

The present invention includes a method of characterizing disease activity in a systemic lupus erythematosus patient (SEE), comprising: obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, wherein the dataset comprises data representing the level of one or more biomarkers in the blood, serum, plasma or urine sample from each of (b) to (g); at least one innate serum or plasma mediator biomarker; at least one adaptive serum or plasma mediator; at least one chemokine/adhesion molecule biomarker; at least one soluble TNF superfamily biomarker; the inflammatory mediator biomarker SCF; at least one SLE-associated autoantibody specificity biomarker; and calculating a Lupus Disease Activity Immune.

TEST METHOD FOR MILD COGNITIVE IMPAIRMENT, TEST REAGENT FOR MILD COGNITIVE IMPAIRMENT, AND METHOD FOR SCREENING THERAPEUTIC CANDIDATE SUBSTANCES FOR MILD COGNITIVE IMPAIRMENT

NºPublicación:  US20260062732A1 05/03/2026
Solicitante: 
BIORADICAL RES INSTITUTE CORP [JP]
US_20260062732_PA

Resumen de: US20260062732A1

0000 Provided is a test method with which mild cognitive impairment (MCI) is detectable and a measurement reagent for use in the test method. A test method for MCI according to the present invention includes a step of measuring the activity of superoxide dismutase (SOD) in a biological sample of a subject.

CIRCULATING BIOMARKER LEVELS FOR DIAGNOSIS AND RISK-STRATIFICATION OF TRAUMATIC BRAIN INJURY

NºPublicación:  US20260063646A1 05/03/2026
Solicitante: 
BRAINBOX SOLUTIONS INC [US]
US_20260063646_PA

Resumen de: US20260063646A1

Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.

Anticuerpos anti-proteína a-beta, métodos y usos de estos

NºPublicación:  CO2026000998A2 05/03/2026
Solicitante: 
F HOFFMANN LA ROCHE AG [CH]
F. HOFFMANN-LA ROCHE AG
CN_121620524_PA

Resumen de: AU2024322991A1

Herein is reported an antibody that binds to human A-beta protein, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain comprising CDRs selected from (1) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 83; or (2) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 83; or (3) CDRs of SEQ 5 ID NO: 85, 86, 87, 81, 82 and 91; or (4) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 91.

COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND/OR TREATMENT OF AMYLOID B PEPTIDE PROTEINOPENIA IN ALZHEIMER'S AND OTHER DISEASES

NºPublicación:  AU2024325238A1 05/03/2026
Solicitante: 
LVIS REGAIN LP
LVIS-REGAIN LP
AU_2024325238_PA

Resumen de: AU2024325238A1

Material compositions and/or methods useful for the prophylaxis and/or treatment of protein depletion (proteinopenia) are provided, including material compositions that retains native function of a peptide/protein while limiting and/or preventing amyloid formation and/or aggregation of said peptide/protein. Material compositions and formulations for enhancing peptide/protein solubility, stability, circulation time, receptor interaction, brain penetrance, CSF half-life, facilitating peptide/protein synthesis and purification are also provided.

METHODS OF TREATING A COGNITIVE IMPAIRMENT

NºPublicación:  AU2024345495A1 05/03/2026
Solicitante: 
GRIFOLS WORLDWIDE OPERATIONS LTD
GRIFOLS WORLDWIDE OPERATIONS LIMITED
AU_2024345495_A1

Resumen de: AU2024345495A1

The disclosure pertains to treating a cognitive impairment, for example, an aging-associated cognitive impairment. In certain aspects, the disclosure describes methods of assaying a sample obtained from a subject having or suspected of having a cognitive impairment for one or more proteins selected from: DLL1, VNN2, VAV3, and SUMF1. In certain embodiments, the cognitive impairment is caused by a neurodegenerative disease, such as Alzheimer's disease. The methods further comprise identifying a subject as likely or not likely to respond positively to the plasma exchange therapy. In even further aspects, the disclosure describes methods for treating a cognitive impairment in the subject by a plasma exchange therapy, wherein based on the specific protein expression data, the subject is identified as likely or not likely to respond positively to the plasma exchange therapy. The plasma exchange therapy can be full and/or low volume plasma exchange. Also provided are kits suitable for performing the methods disclosed herein.

MAGNETIC FORMULATIONS FOR BIOMARKER SAMPLING AND ENHANCED DRUG DELIVERY

NºPublicación:  US20260061081A1 05/03/2026
Solicitante: 
ROCKET SCIENCE HEALTH CORP [CA]
Rocket Science Health Corp
US_20260061081_PA

Resumen de: US20260061081A1

The present disclosure describes formulations, methods, and devices tor biomarker sampling and therapeutic delivery using magnetic formulations. When combined with the application of external magnetic fields, magnetic formulations move within the nasal cavity. Magnetic formulations provide benefits including the ability to: target or steer placement of the formulations via a magnetic field, enhance mixing of the formulation via a magnetic field, enhance biological material collection via antibody-coated magnetic beads, or enhance sample retrieval via a magnetic-tipped inserter. Example biological materials for collection include proteins, enzymes, neural stem cells, and other biomarkers.

Method for the prediction of a risk or severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cell therapy (IECT)

NºPublicación:  US20260063648A1 05/03/2026
Solicitante: 
PAM THERAGNOSTICS GMBH [DE]
US_20260063648_PA

Resumen de: US20260063648A1

0000 The present application is directed to a method for the prediction of a risk of side effects and/or prediction of the severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cells in the frame of an immune effector cell therapy (IECT), and/or for assessing an effect of a treatment of side effects in a cancer patient that has been treated with immune effector cells in the frame of an IECT, the method comprising the steps of a) determining the level of at least one endothelial dysfunction biomarker in a sample of bodily fluid of the patient, and b) correlating the level of the at least one endothelial dysfunction biomarker in the sample to the risk of the side effects and/or the severity of the side effects in the patient and/or to the effect of the treatment of the side effects in the patient. Further aspects relate to corresponding methods stratification and medicaments for use in corresponding treatment.

NANOPORE PEPTIDE PROFILING AND SEQUENCING BY HYDROLYSIS

NºPublicación:  WO2026046058A1 05/03/2026
Solicitante: 
NANJING UNIVERSITY [CN]
WO_2026046058_PA

Resumen de: WO2026046058A1

A method of characterizing a peptide using a nanopore incorporating at least one metal ion as a sensing moiety. A method of profiling or sequencing a polypeptide by fragmenting the polypeptide and then characterizing the fragments using a nanopore incorporating at least one metal ion as a sensing moiety.

NOVEL METHOD

Nº publicación: WO2026047343A1 05/03/2026

Solicitante:

BABRAHAM INST [GB]

WO_2026047343_PA

Resumen de: WO2026047343A1

The present invention is directed to a method of identifying genomic nucleic acid regions associated with chromatin marks, genome binding proteins and/or genomic modifications, and the transcriptome in a sample, said method comprising in situ single step fragmentation and adapter sequence insertion using individual anti-chromatin mark, anti-genome binding protein and/or anti-genomic modification antibody-transposase-adapter complexes, each of said complexes comprising one or more antibodies specific for a chromatin mark, genome binding protein and/or genomic modification of interest with an indexed transposase-adapter sequence, and mRNA transcript capture and in situ reverse transcription. Also provided are methods of identifying chromatin marked, genome binding protein bound and/or modified genomic nucleic acid regions associated with a particular disease state and/or a particular state of developmental differentiation, as well as kits for performing the methods herein.

traducir