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Resultados 53 resultados
LastUpdate Última actualización 02/11/2026 [06:45:00]
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NOVEL RECOMBINANT ANTIBODY SPECIFICALLY BINDING TO B CELL ANTIGEN, AND USE THEREOF

NºPublicación:  EP4818207A1 07/10/2026
Solicitante: 
UIF UNIV INDUSTRY FOUNDATION YONSEI UNIV [KR]
UIF (University Industry Foundation), Yonsei University
EP_4818207_PA

Resumen de: EP4818207A1

0001 The present invention relates to a recombinant polypeptide that specifically binds to B lymphocytes and a composition for preventing or treating B-cell lymphoma, comprising the recombinant polypeptide as an active ingredient. The present invention can significantly enhance direct cell death activity against tumor cells by conjugating concanavalin A, a ligand of MPZL1, to an antibody molecule that recognizes a B-lymphocyte-specific antigen such as CD20. Accordingly, unlike therapeutic antibodies that act mainly through antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADP), the recombinant polypeptide of the present invention does not depend on effector mechanisms of a patient's immune system. Therefore, the recombinant polypeptide can be usefully employed as an effective therapeutic composition even for cancer patients with reduced immune activity.

METHODS FOR THE TREATMENT OF MULTIPLE MYELOMA

NºPublicación:  EP4815987A1 07/10/2026
Solicitante: 
TENEOONE INC [US]
Teneoone, Inc.
US_20250177520_A1

Resumen de: US20250177520A1

Methods of treating multiple myeloma by administering a bispecific antibody that binds to CD3 and BCMA to a patient in need are provided.

BCMA-TARGETED CAR-T CELL THERAPY FOR MULTIPLE MYELOMA

Nº publicación: NL4002684A 06/10/2026

Solicitante:

LEGEND BIOTECH USA INC [US]
JANSSEN BIOTECH INC [US]
LEGEND BIOTECH USA INC.
JANSSEN BIOTECH, INC.

NL_4002684_A

Resumen de: NL4002684A

0001 ABSTRACT Provided herein are methods of treating a subject who has multiple myeloma and has received one to three prior treatment(s). Infusions of chimeric antigen receptor (CAR)-T cells comprising a CAR capable of specifically binding to an 5 epitope of BCMA are administered to the subject.

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