Resumen de: EP4818207A1
0001 The present invention relates to a recombinant polypeptide that specifically binds to B lymphocytes and a composition for preventing or treating B-cell lymphoma, comprising the recombinant polypeptide as an active ingredient. The present invention can significantly enhance direct cell death activity against tumor cells by conjugating concanavalin A, a ligand of MPZL1, to an antibody molecule that recognizes a B-lymphocyte-specific antigen such as CD20. Accordingly, unlike therapeutic antibodies that act mainly through antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADP), the recombinant polypeptide of the present invention does not depend on effector mechanisms of a patient's immune system. Therefore, the recombinant polypeptide can be usefully employed as an effective therapeutic composition even for cancer patients with reduced immune activity.
Resumen de: US20250177520A1
Methods of treating multiple myeloma by administering a bispecific antibody that binds to CD3 and BCMA to a patient in need are provided.
Nº publicación: NL4002684A 06/10/2026
Solicitante:
LEGEND BIOTECH USA INC [US]
JANSSEN BIOTECH INC [US]
LEGEND BIOTECH USA INC.
JANSSEN BIOTECH, INC.
Resumen de: NL4002684A
0001 ABSTRACT Provided herein are methods of treating a subject who has multiple myeloma and has received one to three prior treatment(s). Infusions of chimeric antigen receptor (CAR)-T cells comprising a CAR capable of specifically binding to an 5 epitope of BCMA are administered to the subject.