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LastUpdate Última actualización 14/07/2026 [08:35:00]
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COMBINATION TREATMENT OF CHRONIC MYELOMONOCYTIC LEUKEMIA IN PATIENTS WITH RAS PATHWAY MUTATIONS

NºPublicación:  AU2024370696A1 18/06/2026
Solicitante: 
TARAN THERAPEUTICS INC
THE UNIV OF ADELAIDE
TARAN THERAPEUTICS, INC.
THE UNIVERSITY OF ADELAIDE
AU_2024370696_PA

Resumen de: AU2024370696A1

Methods are provided for treating a subject having chronic myelomonocytic leukemia (CMML), the method comprising: (a) identifying a RAS pathway mutation in tumor cells of the subject, wherein the RAS pathway mutation is a NRAS, KRAS, PTPN-11 and/or CBL mutation; (b) identifying a dominant CBL mutation of CBL variant allele frequency of from <5% to >10%; and (c) administering to the subject identified in step (a) a therapeutically effective amount of an anti-hGM-CSF antibody.

METHODS OF TREATMENT WITH T CELL THERAPY AND IMMUNOMODULATORY AGENT MAINTENANCE THERAPY

NºPublicación:  US20260166082A1 18/06/2026
Solicitante: 
CELGENE CORP [US]
Celgene Corporation
US_20260166082_A1

Resumen de: US20260166082A1

Provided herein are adoptive cell therapy methods involving the administration of genetically engineered cells followed by an immunomodulatory agent maintenance therapy for treating disease and conditions, including certain plasma cell malignancy. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) specific to B-cell maturation antigen (BCMA). In some embodiments, the methods are for treating subjects with multiple myeloma (MM), such as high risk multiple myeloma or newly diagnosed multiple myeloma (NDMM). In some embodiments, the methods are for treating subjects who experienced an early relapse, an inadequate response or a suboptimal response after frontline autologous stem cell transplant therapy (ASCT).

DILUTED CARFILZOMIB FOR USE IN TREATING MULTIPLE MYELOMA

Nº publicación: EP4757826A2 17/06/2026

Solicitante:

AMGEN INC [US]
AMGEN, INC.

WO_2025035020_PA

Resumen de: WO2025035020A2

Provided herein are methods for treating a disease or condition selected from the group consisting of cancer, autoimmune disease, graft or transplant-related condition, neurodegenerative disease, fibrotic-associated condition, ischemic-related conditions, infection (viral, parasitic or prokaryotic) and diseases associated with bone loss, the method comprising administering to a patient a therapeutically effective amount of carfilzomib or a pharmaceutically acceptable salt thereof at a dose volume of 10 mL/kg or higher. Also provided herein are methods for treating multiple myeloma in a patient, comprising administering to the patient a pharmaceutical composition comprising carfilzomib or a pharmaceutically acceptable salt thereof and an aqueous carrier, wherein the carfilzomib is administered at a dose volume of 2.5 mL/kg or higher and/or at a concentration of less than 2 mg/mL.

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