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LastUpdate Última actualización 16/11/2025 [07:24:00]
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Solicitudes publicadas en los últimos 60 días / Last 60 days publications
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COMPOSITIONS AND METHODS FOR TREATING PARKINSON'S DISEASE

NºPublicación:  EP4642905A1 05/11/2025
Solicitante: 
MOTIGENIX SINGAPORE PTE LTD [SG]
RELIABLE HOLDINGS CO LTD [SC]
Motigenix Singapore Pte. Ltd,
Reliable Holdings Co., Ltd
KR_20250121452_PA

Resumen de: CN120435551A

Provided herein are compounds, compositions, uses, and methods for increasing cell viability of dopaminergic neurons, or for preventing or treating dopaminergic neuronal death. In certain examples, methods are provided for reducing symptoms and/or for preventing or treating Parkinson's disease in an individual in need thereof, which can include the step of treatment with a GDP-binding form of Rab1a (Rab1aGDP), one or more manifestation nucleic acids encoding Rab1aGDP, or a combination thereof.

PHARMACEUTICAL COMBINATION OF DONEPEZIL AND CEVIMELINE

NºPublicación:  EP4643857A1 05/11/2025
Solicitante: 
LUKA ASSETS INC [US]
Luka Assets Inc
EP_4643857_A1

Resumen de: EP4643857A1

The present invention relates to combination of donepezil or a pharmaceutically acceptable salt thereof and cevimeline or a pharmaceutically acceptable salt thereof for use in the treatment of Alzheimer's disease. Furthermore, a pharmaceutical formulation containing donepezil or a pharmaceutically acceptable salt thereof, cevimeline or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient is provided.

PRIDOPIDINE FOR TREATING JUVENILE HUNTINGTON'S DISEASE

NºPublicación:  EP4642457A1 05/11/2025
Solicitante: 
PRILENIA NEUROTHERAPEUTICS LTD [IL]
Prilenia Neurotherapeutics Ltd
CN_120569199_A

Resumen de: CN120569199A

Provided herein is a method of treating teenager Huntington's disease in a subject in need thereof, the method comprising orally administering a pharmaceutical composition comprising pridopidine and/or an analog thereof or a pharmaceutically acceptable salt thereof.

METHODS AND COMPOSITIONS FOR REDUCING SYMPTOMS OF PARKINSON'S DISEASE

NºPublicación:  MX2025012236A 03/11/2025
Solicitante: 
NEURODERM LTD [IL]
NEURODERM, LTD
TW_202448421_A

Resumen de: MX2025012236A

Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in a patient in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof.

COMBINATION TREATMENT OF SCYLLO-INOSITOL AND VITAMIN D AND/OR OTHER VITAMINS OR ACTIVE INGREDIENTS TO TREAT COGNITIVE DISORDERS

NºPublicación:  MX2025002654A 03/11/2025
Solicitante: 
EIRGEN PHARMA LTD [IE]
EIRGEN PHARMA, LTD
CN_120826223_PA

Resumen de: MX2025002654A

The disclosure relates to a combination of active ingredients/adjuvants for the treatment of neurological disorders and diseases such as Alzheimer's disease and mild cognitive impairment (MCI) and memory and cognitive disorders and conditions. In particular, combinations of scyllo-inositol and treatments for Alzheimer's disease such as aducanumab and/or combinations with essential fatty acids such as mixtures of linolenic acid/linoleic acid or vitamin D or vitamin D compounds such as calcifediol are disclosed as useful. The combinations may be in the form of separate dosage forms of each active ingredient or may be an oral dosage form having multiple active ingredients in a single capsule or tablet or oral solution. The invention also relates to a method of treating patients having mild cognitive impairment with MMSE criteria of between 22 to 26 with a pharmaceutically effective amount of scyllo-inositol to treat the disease and to slow down progression to Alzheimer's disease.

GENE THERAPY VECTORS FOR USE IN PARKINSON'S DISEASE

NºPublicación:  MX2025009097A 03/11/2025
Solicitante: 
JANSSEN PHARMACEUTICA NV [BE]
JANSSEN PHARMACEUTICA NV
KR_20250142386_PA

Resumen de: MX2025009097A

Disclosed herein are recombinant gene therapy vectors comprising a PTEN-induced kinase 1 (PINK1) encoding gene that is operatively linked to a promoter and methods of using the recombinant therapy vectors for inhibiting, reducing, or delaying degeneration or death of neurons of a subject.

ANTI-CD2 ANTIBODIES FOR AMYOTROPHIC LATERAL SCLEROSIS

NºPublicación:  MX2025009971A 03/11/2025
Solicitante: 
ZELARION MALTA LTD [MT]
ZELARION MALTA LIMITED
WO_2024180185_PA

Resumen de: MX2025009971A

Provided herein is an anti-CD2 antibody or antigen binding fragment thereof for treating and/or preventing ALS in a subject in need thereof.

MIVELSIRAN COMPOSITIONS AND METHODS OF USE THEREOF

NºPublicación:  MX2025012729A 03/11/2025
Solicitante: 
ALNYLAM PHARMACEUTICALS INC [US]
ALNYLAM PHARMACEUTICALS, INC
AU_2024260719_A1

Resumen de: MX2025012729A

The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the APP gene, as well as methods of inhibiting expression of an APP gene and methods of treating subjects having an APP-associated disease or disorder, such as Alzheimer's disease (e.g., early onset Alzheimer's disease), using such dsRNAi agents and compositions.

Methods of treatment and prevention of alzheimer's disease

NºPublicación:  IL323583A 01/11/2025
Solicitante: 
EISAI R& D MAN CO LTD [JP]
EISAI R& D MANAGEMENT CO. LTD
IL_323583_A

Resumen de: CN118924896A

The invention relates to a method for treating and preventing Alzheimer's disease. The present invention provides methods of reducing clinical decline in a subject suffering from early Alzheimer's disease; a method of converting an amyloid-positive subject suffering from early Alzheimer's disease to an amyloid-negative subject; methods of reducing brain amyloid levels in a subject; and methods of preventing Alzheimer's disease comprising administering a composition comprising a therapeutically effective amount of at least one anti-A beta profibril antibody. In some embodiments, the subject is ApoE4 positive. In some embodiments, the at least one anti-A beta protofibril antibody is BAN2401.

Methods and compositions for reducing symptoms of parkinson's disease

NºPublicación:  IL323682A 01/11/2025
Solicitante: 
NEURODERM LTD [IL]
ADAR LIAT [IL]
LOPES NELSON FELIX [IL]
SALIN LAURENCE [IL]
YARDENI TAMAR [IL]
SASSON NISSIM [IL]
OREN SHEILA [IL]
YARITA HIKARI [JP]
HIMIZU MIKIO [JP]
VOSTOKOVA NATALIA [IL]
NEURODERM LTD,
ADAR Liat,
LOPES Nelson Felix,
SALIN Laurence,
YARDENI Tamar,
SASSON Nissim,
OREN Sheila,
YARITA Hikari,
HIMIZU Mikio,
VOSTOKOVA Natalia
IL_323682_A

Resumen de: MX2025012236A

Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in a patient in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof.

METHODS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

NºPublicación:  US2025334594A1 30/10/2025
Solicitante: 
ELEDON PHARMACEUTICALS INC [US]
ELEDON PHARMACEUTICALS, INC
US_2025334594_PA

Resumen de: US2025334594A1

Provided herein are methods and kits for treating neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's Disease Parkinson's Disease, Myasthenia Gravis, Multifocal Motor Neuropathy, Primary Lateral Sclerosis, Spinal Muscular Atrophy, Kennedy's Disease, and Spinocerebellar Ataxia. Also provided are methods of predicting or measuring a response to a treatment by measuring biomarker levels in a sample, and methods of modulating biomarker levels.

USE OF ACHYRANTHES BIDENTATA POLYPEPTIDE COMBINED WITH HUMAN UMBILICAL CORD MESENCHYMAL STEM CELL-DERIVED EXOSOME IN PREPARATION OF DRUG FOR PREVENTING AND/OR TREATING PARKINSON'S DISEASE

NºPublicación:  WO2025223573A1 30/10/2025
Solicitante: 
NANTONG UNIV [CN]
\u5357\u901A\u5927\u5B66
WO_2025223573_PA

Resumen de: WO2025223573A1

Provided in the present invention is the use of an Achyranthes bidentata polypeptide combined with a human umbilical cord mesenchymal stem cell-derived exosome in the preparation of a drug for preventing and/or treating Parkinson's disease. A Parkinson's disease (PD) model mouse is established using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and then an Achyranthes bidentata polypeptide is used in combination with a human umbilical cord mesenchymal stem cell-derived exosome to treat the mouse. It is found that the treatment can significantly relieve PD-related symptoms, for example, restoring the number of dopaminergic neurons in the substantia nigra, improving the expression of tyrosine hydroxylase in the midbrain, relieving motor and olfactory dysfunction of the PD model mouse, reducing the activation of microglia and astrocytes in the olfactory bulb and midbrain, and improving the activity of neurons in the olfactory bulb.

1,4-POLYISOPRENE DISPERSION SYSTEM, PHARMACEUTICAL ACTIVE INGREDIENT AND USE THEREOF

NºPublicación:  AU2023437235A1 30/10/2025
Solicitante: 
SUZHOU HAIYI BIOMEDICAL TECHNOLOGY CO LTD
SUZHOU HAIYI BIOMEDICAL TECHNOLOGY CO., LTD
AU_2023437235_PA

Resumen de: AU2023437235A1

A 1,4-polyisoprene dispersion system, a pharmaceutical active ingredient and the use thereof. The dispersion system is stable in the gastric acid environment of mammals without precipitation of 1,4-polyisoprene clots, has no oral toxicity to mammals, and does not contain allergens. The 1,4-polyisoprene dispersion system comprises a 1,4-polyisoprene solution dispersion system and a 1,4-polyisoprene emulsion dispersion system. The 1,4-polyisoprene dispersion system can serve as a pharmaceutical active ingredient to be used for preparing drugs for treating diseases including atherosclerotic cardiovascular and cerebrovascular diseases, type II diabetes, hypercholesterolemia, hypertriglyceridemia, fatty liver, colitis, obesity, polycystic ovarian syndrome and Alzheimer's disease.

QPCTL INHIBITORS

NºPublicación:  WO2025224308A1 30/10/2025
Solicitante: 
SCENIC IMMUNOLOGY B V [NL]
SCENIC IMMUNOLOGY B.V
WO_2025224308_PA

Resumen de: WO2025224308A1

The current invention relates to QPCTL inhibitors represented by formula (I), and corresponding compositions and uses. Preferably, the inhibitors and compositions are for use in the treatment of cancer, neurodegenerative diseases such as Alzheimer's disease, synucleinopathies, Huntington's disease, bacterial infections such as periodontitis and related disorders, and inflammatory diseases.

METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS

NºPublicación:  US2025332164A1 30/10/2025
Solicitante: 
INTRA CELLULAR THERAPIES INC [US]
INTRA-CELLULAR THERAPIES, INC
US_2025332164_A1

Resumen de: US2025332164A1

Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.

NEW PEPTIDE PP1 OF FKBP52 AND DERIVATIVES AND USE OF THE THERAPEUTIC PEPTIDES THAT INHIBIT PATHOLOGICAL TAU AGGREGATION FOR THERAPEUTIC PURPOSES

NºPublicación:  WO2025224502A1 30/10/2025
Solicitante: 
INST BAULIEU FONDS DE DOTATION [FR]
INSTITUT BAULIEU FONDS DE DOTATION
WO_2025224502_A1

Resumen de: WO2025224502A1

The invention is directed to peptide fragments of FKBP52 that inhibit Tau protein aggregation and ameliorate tauopathies like Alzheimer's Disease (AD). It also involves modifications to these peptides to improve their pharmacokinetic and pharmacodynamic properties.

FKBP52-DERIVED THERAPEUTIC PEPTIDES THAT INHIBIT PATHOLOGICAL TAU AGGREGATION FOR THERAPEUTIC PURPOSES

NºPublicación:  WO2025224501A1 30/10/2025
Solicitante: 
INST BAULIEU FONDS DE DOTATION [FR]
INSTITUT BAULIEU FONDS DE DOTATION
WO_2025224501_A1

Resumen de: WO2025224501A1

The invention is directed to peptide fragments of FKBP52 that inhibit Tau protein aggregation and ameliorate tauopathies like Alzheimer's Disease (AD). It also involves modifications to these peptides to improve their pharmacokinetic and pharmacodynamic properties.

METHODS OF TREATING OXIDIZED PHOSPHATIDYLCHOLINE-ASSOCIATED DISEASES

NºPublicación:  AU2024260221A1 30/10/2025
Solicitante: 
VECTORY THERAPEUTICS B V
VECTORY THERAPEUTICS B.V
AU_2024260221_PA

Resumen de: AU2024260221A1

Provided herein are methods of treating diseases and disorders related to TDP-43 aggregation (e.g., ALS) with an antibody that specifically binds to OxPC or a polynucleotide encoding an antibody that specifically binds to OxPC.

METHODS FOR DETECTING THE PRESENCE OF AT LEAST ONE MISFOLDED FORM OF SOD1 IN A BIOLOGICAL SAMPLE

NºPublicación:  AU2024284125A1 30/10/2025
Solicitante: 
MCLAUGHLIN RES INSTITUTE FOR BIOMEDICAL SCIENCES
MCLAUGHLIN RESEARCH INSTITUTE FOR BIOMEDICAL SCIENCES
AU_2024284125_PA

Resumen de: AU2024284125A1

Disclosed herein are methods for detecting the presence of at least one misfolded form of human Superoxide Dismutase 1 (SOD1) in a biological sample obtained from a human subject. In some aspects, the subject is suspected of having, or has, one or more neurodegenerative diseases, such as, for example, Amyotrophic Lateral Sclerosis, Parkinson's disease, or Alzheimer's disease.

METHOD OF PREVENTING AND TREATING ALZHEIMER'S DISEASE AND RELATED DEMENTIAS WITH DRUGS INHIBITING THE INTERACTION BETWEEN 14-3-3G PROTEIN AND HEXOKINASE-1 PROTEIN

NºPublicación:  EP4637824A1 29/10/2025
Solicitante: 
BIOVENTURES LLC [US]
AYYADEVARA SRINIVAS [US]
GANNE AKSHATHA [US]
BALASUBRAMANIAM MEENAKSHISUNDARAM [US]
VALLURUPALLI SRIKANTH [US]
SHMOOKLER REIS ROBERT J [US]
BIOVENTURES, LLC,
Ayyadevara, Srinivas,
Ganne, Akshatha,
Balasubramaniam, Meenakshisundaram,
Vallurupalli, Srikanth,
Shmookler Reis, Robert, J
WO_2024155781_A1

Resumen de: WO2024155781A1

A method of treating and preventing Alzheimer's disease and related dementias is disclosed. The method includes administering to a patient an effective amount of a drug that is operable to inhibit an interaction between 14-3-3G protein and hexokinase-1 protein in the patient. The drug may be ezetimibe, conivaptan, lumacaftor, ebastine, digitoxin, or astemizole.

NNAT Composition for delaying or treating Huntington's disease through NNAT expression activation

NºPublicación:  KR20250152502A 23/10/2025
Solicitante: 
고려대학교산학협력단
KR_20250152502_PA

Resumen de: KR20250152502A

본 발명은 NNAT 발현 촉진제 또는 활성 촉진제를 유효성분으로 포함하는 헌팅턴병 예방, 개선 또는 치료용 조성물에 대한 것으로, 본 발명은 헌팅턴병 환자에게서 발현 및 활성이 감소된 NNAT의 발현 또는 활성을 촉진함으로써, 헌팅턴병 예방 또는 치료 효과를 가질 수 있는 다양한 물질 및 이의 스크리닝 방법에 대한 것이다.

COMPOSITIONS CONTAINING A SYNERGISTIC COMBINATION OF MEMANTINE AND VITAMIN D

NºPublicación:  WO2025219389A1 23/10/2025
Solicitante: 
SYNAPTYS NEUROSCIENCE [FR]
SYNAPTYS NEUROSCIENCE
WO_2025219389_A1

Resumen de: WO2025219389A1

The invention relates to compositions comprising a synergistic combination of memantine and vitamin D, to the method for preparing same and to the use thereof in the prevention and treatment of neurodegenerative diseases, in particular Alzheimer's disease.

PM20D1-DERIVED N-OLEOYL-L-LEUCINE FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE

NºPublicación:  WO2025219147A1 23/10/2025
Solicitante: 
CONSEJO SUPERIOR DE INVESTIG CIENTIFICAS [ES]
CONSEJO SUPERIOR DE INVESTIGACIONES CIENT\u00CDFICAS
WO_2025219147_A1

Resumen de: WO2025219147A1

The invention relates to PM20D1 -derived N-oleoyl-L-Leucine (C18:1-Leu) for the treatment and/or prevention of neurodegenerative diseases, particularly for the treatment and/or prevention of Parkinson disease, multiple sclerosis disease, amyotrophic lateral sclerosis disease and Alzheimer's disease.

NOVEL BENZIMIDAZOLE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY AND USE THEREOF

NºPublicación:  WO2025220783A1 23/10/2025
Solicitante: 
INDUSTRY UNIV COOPERATION FOUNDATION HANYANG UNIV ERICA CAMPUS [KR]
\uD55C\uC591\uB300\uD559\uAD50 \uC5D0\uB9AC\uCE74\uC0B0\uD559\uD611\uB825\uB2E8
WO_2025220783_PA

Resumen de: WO2025220783A1

The present invention relates to a novel benzimidazole derivative compound, an isomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same. The benzimidazole derivative compound according to the present invention exhibits selective inhibitory activity against JNK, particularly JNK3, and thus can be used as a pharmaceutical composition for the prevention and treatment of degenerative brain diseases, such as Alzheimer's disease and Parkinson's disease, or cancer.

PHARMACEUTICAL FORMULATIONS FOR SUBCUTANEOUS ADMINISTRATION

Nº publicación: US2025325507A1 23/10/2025

Solicitante:

ABBVIE INC [US]
AbbVie Inc

US_2025325507_PA

Resumen de: US2025325507A1

The present disclosure relates to compositions of levodopa 4′-monophosphate and carbidopa 4′-monophosphate having a weight by weight ratio of about 20:1 and methods of treating Parkinson's disease and associated conditions by subcutaneous administration of such compositions.

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