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LastUpdate Última actualización 02/11/2026 [10:52:00]
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Solicitudes publicadas en los últimos 60 días / Last 60 days publications
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USE OF MICRORNAS AS TOOLS FOR THE DIAGNOSIS AND DIFFERENTIATION OF TAUOPATHIES

NºPublicación:  US20260327703A1 22/10/2026
Solicitante: 
UNIVERSITA\u2019 DI TRENTO [IT]
ST SUPERIORE DI SANITA\u2019 [IT]
UNIV DEGLI STUDI DI ROMA \u201CLA SAPIENZA [IT]
UNIVERSITA\u2019 DI TRENTO
ISTITUTO SUPERIORE DI SANITA\u2019
UNIVERSIT\u00C1 DEGLI STUDI DI ROMA \u201CLA SAPIENZA\"
US_20260327703_A1

Resumen de: US20260327703A1

0000 The present invention relates to microRNAs for use in diagnostic methods for diagnosing and/or for distinguishing by diagnosis Alzheimer's disease (AD), Frontotemporal Dementia (FTD), and possibly other tauopathies, and/or for measuring therapeutic effect of a treatment of FTD or AD.

Methods of Treating Amyotrophic Lateral Sclerosis

NºPublicación:  US20260325476A1 22/10/2026
Solicitante: 
BIOJIVA LLC [US]
BioJiva LLC
US_20260325476_A1

Resumen de: US20260325476A1

0000 Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated linoleic acid or an ester thereof.

Anti-TDP-43 Binding Molecules and Uses Thereof

NºPublicación:  US20260327296A1 22/10/2026
Solicitante: 
AC IMMUNE SA [CH]
AC Immune SA
US_20260327296_A1

Resumen de: US20260327296A1

0000 The present invention is in the field of transactive response DNA binding protein with a molecular weight of 43 kDa (TARDB or also TDP-43). The invention relates to TDP-43 specific binding molecules, in particular to anti-TDP-43 antibodies or an antigen-binding fragment or a derivative thereof and uses thereof. The present invention provides means and methods to diagnose, prevent, alleviate and/or treat a disease, disorder and/or abnormality associated with TDP-43 aggregates including but not limited to Frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Chronic Traumatic Encelopathy (CTE), and limbic-predominant age-related TDP-43 encephalopathy (LATE).

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PARKINSON'S DISEASE AND METHOD FOR SCREENING SAME, METHOD FOR PREVENTING OR TREATING PARKINSON'S DISEASE USING SAID PHARMACEUTICAL COMPOSITION, AND USAGE IN MANUFACTURE OF SAID PHARMACEUTICAL COMPOSITION

NºPublicación:  WO2026220933A1 22/10/2026
Solicitante: 
FUJITA ACAD [JP]
\u5B66\u6821\u6CD5\u4EBA\u85E4\u7530\u5B66\u5712
WO_2026220933_A1

Resumen de: WO2026220933A1

Provided is a pharmaceutical composition that has fewer side effects and that makes it possible to obtain an effect of preventing or treating Parkinson's disease A pharmaceutical composition for preventing or treating Parkinson's disease according to an embodiment of the present invention contains a nucleic acid that inhibits the expression of Rap1GAP.

HETEROCYCLIC PYRIDINONE COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE

NºPublicación:  EP4823679A1 21/10/2026
Solicitante: 
VIGIL NEUROSCIENCE INC [US]
Vigil Neuroscience, Inc.
WO_2025128873_PA

Resumen de: WO2025128873A1

The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE

NºPublicación:  EP4823678A1 21/10/2026
Solicitante: 
VIGIL NEUROSCIENCE INC [US]
Vigil Neuroscience, Inc.
WO_2025128848_PA

Resumen de: WO2025128848A1

The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

AZAINDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3

NºPublicación:  EP4824066A1 21/10/2026
Solicitante: 
MERCK SHARP & DOHME LLC [US]
Merck Sharp & Dohme LLC
WO_2025128781_A1

Resumen de: WO2025128781A1

Novel compounds of Formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, obesity, gout, pseudogout, CAPS, NASH, MASH, fibrosis, heart failure, idiopathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease, dementia with Lewy bodies (DLB), and traumatic brain injury.

INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3

NºPublicación:  EP4824065A1 21/10/2026
Solicitante: 
MERCK SHARP & DOHME LLC [US]
Merck Sharp & Dohme LLC
CN_122422322_A

Resumen de: CN122422322A

Novel compounds of formula (I), and pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and are useful in the treatment, prevention, management, amelioration, control and inhibition of diseases mediated by NLRP3. The compounds of the invention are useful for treating, preventing or managing diseases, disorders and conditions mediated by NLRP3, such as, but not limited to, NLRP3. Obesity, gout, pseudogout, CAPS, NASH, MASH, fibrosis, osteoarthritis, atherosclerosis, heart failure, idiopathic pericarditis, myocarditis, atopic dermatitis, hidradenitis suppurativa, inflammatory bowel disease, cancer, Alzheimer's disease, Parkinson's disease, Lewy body dementia (DLB) and traumatic brain injury. (I).

SPIROPIPERIDINE UREA-DERIVED COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS

NºPublicación:  EP4824069A1 21/10/2026
Solicitante: 
HOFFMANN LA ROCHE [CH]
F. Hoffmann-La Roche AG
WO_2025125135_A1

Resumen de: WO2025125135A1

The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, A, B, C, and R1 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as soluble epoxide hydrolase inhibitors.

NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS

NºPublicación:  AU2025255577A1 15/10/2026
Solicitante: 
PFIZER INC
PFIZER INC.
AU_2025255577_A1

Resumen de: AU2025255577A1

The disclosure relates to compounds of the disclosure and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of the disclosure may be useful in the treatment, prevention, suppression and amelioration of disease(s) such as atopic dermatitis, eosinophilic gastritis, atopic keratoconjunctivitis, allergy, alopecia, Alzheimer's disease, asthma, atherosclerosis, Bechet's disease, bullous pemphigoid, cancer, chronic obstructive pulmonary disease, chronic pruritis, chronic urticaria, Crohn's disease (CD), dermatitis, diabetic kidney disease, eosinophilic esophagitis, fungal keratitis, gout, idiopathic pulmonary fibrosis (IPF), keloids, non-alcoholic steatohepatitis (NASH), primary biliary cirrhosis, prurigo nodularis, psoriasis, psoriatic arthritis, rhinosinusitis, scleroderma, systemic lupus erythematosus (SLE), systemic sclerosis, ulcerative colitis (UC), vitiligo, or hidradenitis suppurativa. The compounds of the disclosure may be useful in the treatment, prevention, suppression and amelioration of a dermatological condition or a respiratory condition.

Methods and compositions for modulation of tau proteins

NºPublicación:  AU2026238094A1 15/10/2026
Solicitante: 
SANGAMO THERAPEUTICS INC
Sangamo Therapeutics, Inc.
AU_2026238094_A1

Resumen de: AU2026238094A1

METHODS AND COMPOSITIONS FOR MODULATION OF TAU The present disclosure is in the field of diagnostics and therapeutics for Alzheimer’s Disease. ep e p

METHODS OF USE OF (4R,5R)-5-(2-CHLOROPHENYL)-4-(5-(PHENYLETHYNYL)PYRIDIN-3-YL)OXAZOLIDIN-2-ONE

NºPublicación:  AU2025233448A1 15/10/2026
Solicitante: 
ALLYX THERAPEUTICS INC
ALLYX THERAPEUTICS, INC.
AU_2025233448_PA

Resumen de: AU2025233448A1

The present disclosure provides methods of treating Alzheimer's disease and other disorders using (4R,5R)-5-(2-chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one (Compound 1).

BISPHOSPHONATES FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS, SUCH AS ALZHEIMER'S DISEASE

NºPublicación:  WO2026215661A1 15/10/2026
Solicitante: 
SALZ BIOSCIENCES B V [NL]
SALZ BIOSCIENCES B.V.
WO_2026215661_A1

Resumen de: WO2026215661A1

The present disclosure relates to the use of a bisphosphonate, specifically tiludronate, etidronate, clodronate, pamidronate, zoledronate, and combinations thereof, for the treatment of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, among others. Additionally, the disclosure encompasses a method for treating neurodegenerative disorders by administering an effective amount of a bisphosphonate to a subject in need thereof.

NOVEL COMBINATORIAL THERAPIES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES

NºPublicación:  WO2026215248A1 15/10/2026
Solicitante: 
ENEMSA PHARMA [FR]
ENEMSA PHARMA
WO_2026215248_A1

Resumen de: WO2026215248A1

The present invention concerns the treatment of neurodegenerative disorders and provides for novel treatments for such disorders, Alzheimer disease, Parkinson Disease and Amyotrophic Lateral Sclerosis in particular. It is also directed to novel therapeutic combinations useful for treating such disorders.

AAV GENE THERAPY DELIVERY VECTOR FOR ALS

NºPublicación:  WO2026217520A1 15/10/2026
Solicitante: 
RUTGERS THE STATE UNIV OF NEW JERSEY [US]
PANATHERA INC [US]
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
PANATHERA, INC.
WO_2026217520_A1

Resumen de: WO2026217520A1

The present disclosure provides methods and compositions for treating Amyotrophic Lateral Sclerosis (ALS) in a subject in need thereof. In certain embodiments, the method comprises administering to the subject an effective amount of a composition comprising a recombinant adeno-associated virus (AAV) vector comprising a nucleic acid encoding a trophic factor operably linked to a muscle-specific promoter. In certain embodiments, the trophic factor is Brain-Derived Neurotrophic Factor (BDNF). In certain other embodiments, the trophic factor is Growth Arrest-Specific 6 (GAS6).

DIAMINE OXIDASE COMPOSITIONS AND METHODS FOR GENERATING ACTIVE POLYAMINE METABOLITES AND FOR TREATING INFLAMMATION, ALLERGIES, MAST CELL DISORDERS, AND AGE-RELATED DISORDERS

NºPublicación:  WO2026217660A1 15/10/2026
Solicitante: 
CAS PROPERTIES LLC [US]
CAS PROPERTIES, LLC
WO_2026217660_A1

Resumen de: WO2026217660A1

Compositions comprising a pharmaceutically effective amount of diamine oxidase (DAO) or a homolog thereof, for the generation of active polyamine metabolites in a subject in need thereof. The compositions may further optionally include one or more polyamines and/or one or more polyphenols. Senolytic compositions comprising DAO and tetramethoxyluteolin (TML) for selectively targeting and eliminating senescent cells are also provided. In certain embodiments, the disclosed compositions and methods of using the compositions are effective for the treatment or prevention of, among other conditions and disorders, inflammation and inflammation-related disorders, allergies and allergic reactions, mast cell disorders including MCAS, histamine intolerance, and various age-related disorders including Alzheimer's disease, Parkinson's disease, and systemic sclerosis. The Applicant has recognized that the beneficial effects of polyamine therapy are derived from polyamine metabolites generated through DAO-mediated enzymatic conversion, and that unmetabolized polyamines can activate mast cells via MRGPRX2, causing or exacerbating allergic and inflammatory states.

INHIBITORS OF CYCLIC ADP RIBOSE HYDROLASE AND METHODS OF USE THEREOF

NºPublicación:  WO2026217770A1 15/10/2026
Solicitante: 
FLAGSHIP PIONEERING INNOVATIONS VI LLC [US]
FLAGSHIP PIONEERING INNOVATIONS VI, LLC
WO_2026217770_A1

Resumen de: WO2026217770A1

The disclosure provides compounds, in part, compounds of Formula I and their use in treating medical diseases or disorders, such as neurodegenerative diseases, e.g., Parkinson's disease. Pharmaceutical compositions and methods of making compounds of the disclosure are provided. The compounds are contemplated to be modulators, e.g., inhibitors, of cyclic ADP ribose hydrolase (CD38).

COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS

NºPublicación:  WO2026217497A1 15/10/2026
Solicitante: 
THE REGENTS OF THE UNIV OF CALIFORNIA [US]
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
WO_2026217497_A1

Resumen de: WO2026217497A1

The present disclosure relates to compounds that are capable of inhibiting PRMT8 and/or upregulating SirTl. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease) using such compounds.

METHOD FOR TREATING SLEEP ISSUES IN PARKINSON'S DISEASE PATIENTS

NºPublicación:  WO2026217441A2 15/10/2026
Solicitante: 
AMNEAL PHARMACEUTICALS LLC [US]
AMNEAL PHARMACEUTICALS, LLC

A HETEROCYCLIC COMPOUND AND A METHOD OF SYNTHESIS THEREOF

NºPublicación:  WO2026215819A1 15/10/2026
Solicitante: 
INDIAN INST OF TECHNOLOGY BANARAS HINDU UNIVERSITY VARANASI [IN]
INDIAN INSTITUTE OF TECHNOLOGY (BANARAS HINDU UNIVERSITY), VARANASI
WO_2026215819_A1

Resumen de: WO2026215819A1

The present invention relates to the field of organic chemistry and drug design. Here, the present invention provides a novel substituted quinazolinone compound of formula I and a robust and reproducible method of preparation of the heterocyclic compound of formula I for the management of Alzheimer's disease. The method of synthesis comprises of formation of a heterocyclic intermediate of formula II through the preparation of a benzoic acid intermediate and metal free cyclization of the benzoic acid intermediate and further subjecting the heterocyclic intermediate of formula II to C–N bonding with substituted aromatic amines by Buckwald Hartwig reaction to yield the heterocyclic compound of formula I. Moreover, the present invention provides pure heterocyclic compound with higher yields with milder reaction conditions, environment friendly and cost-effective reactants and reagents for management of Alzheimer's disease.

AMNION-DERIVED CELL SECRETOME COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES

NºPublicación:  WO2026217569A1 15/10/2026
Solicitante: 
NOVEOME BIOTHERAPEUTICS INC [US]
NOVEOME BIOTHERAPEUTICS, INC
WO_2026217569_A1

Resumen de: WO2026217569A1

Methods and compositions for treating Alzheimer's disease and related neurodegenerative conditions using intranasal nose-to-brain delivery of ST266, an amnion-derived cell secretome are described. ST266 is a multi-component, acellular biologic composition produced from amnion-derived multipotent progenitor (AMP) cells under cGMP conditions and comprising a plurality of anti-inflammatory, neuroprotective, anti-apoptotic, and regenerative cytokines and growth factors. When administered intranasally, ST266 bypasses the blood-brain barrier and simultaneously targets multiple pathological mechanisms underlying Alzheimer's disease, including neuroinflammation, insulin dysregulation, oxidative stress, neuronal damage, and synaptic dysfunction. The invention encompasses pharmaceutical compositions formulated for intranasal nose-to-brain delivery, methods of treating Alzheimer's disease by administering such compositions, and methods of reducing neuroinflammation and improving insulin regulation in the central nervous system. The non-invasive nature of intranasal delivery offers significant advantages in patient compliance and minimization of systemic side effects.

HETEROCYCLIC COMPOUNDS FOR IMAGING AGGREGATED TAU IN TAUOPATHIES

NºPublicación:  US20260317296A1 15/10/2026
Solicitante: 
UNIV OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US]
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA [US]
University of Pittsburgh - Of the Commonwealth System of Higher Education
The Trustees of the University of Pennsylvania
US_20260317296_A1

Resumen de: US20260317296A1

0000 Provided are heterocyclic compounds of Formula I or Formula II or their pharmaceutically pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers for imaging tau aggregates. Compounds of Formula I or Formula II may be used for the detection of tau aggregates in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy.

SMALL MOLECULE HUMANIN MIMETICS

NºPublicación:  US20260317384A1 15/10/2026
Solicitante: 
THE REGENTS OF THE UNIV OF CALIFORNIA [US]
The Regents of the University Of California
US_20260317384_A1

Resumen de: US20260317384A1

0000 The disclosure provides humanin mimetics that increase neuronal p-AKT and enhance p-gp130 as a new therapeutic class for chronic diseases such as Alzheimer's disease.

APOE GENE THERAPY

NºPublicación:  US20260315626A1 15/10/2026
Solicitante: 
SPARK THERAPEUTICS INC [US]
Spark Therapeutics, Inc.
US_20260315626_A1

Resumen de: US20260315626A1

0000 The present relates to polynucleotide constructs encoding an ApoE3 related protein optionally containing one or more intron. Potential uses of the different constructs include gene therapy targeting one or more disease or disorder, for example, diseases or disorders related to cholesterol levels, atherosclerosis, coronary heart disease, dementia, cerebral amyloid angiopathy, or Alzheimer's disease.

LEVODOPA DOSING REGIMEN

Nº publicación: US20260315423A1 15/10/2026

Solicitante:

AMNEAL PHARMACEUTICALS LLC [US]
Amneal Pharmaceuticals, LLC

US_20260315423_A1

Resumen de: US20260315423A1

The invention is a method for treating patients with Parkinson's disease by orally administering a controlled release levodopa formulation and the method provides an improvement of a patient's total post-dose “Off” time, total post dose “On” time and total post dose “Good On” time compared to post-dose of treatment regimens with oral immediate release levodopa tablets.

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