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LastUpdate Última actualización 28/02/2026 [07:48:00]
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Solicitudes publicadas en los últimos 150 días / Applications published in the last 150 days
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SYSTEMS AND METHODS FOR PREDICTING RESPONSE TO ANTI-TNF THERAPIES

NºPublicación:  US20260057960A1 26/02/2026
Solicitante: 
SCIPHER MEDICINE CORP [US]
Scipher Medicine Corporation
US_20260057960_PA

Resumen de: US20260057960A1

Disclosed herein are methods and systems for administering therapy to subjects who have been determined to display or not display a gene expression response signature established to distinguish between responsive and non-responsive prior subjects who have received the therapy. The subject and prior subjects may suffer from a disease, disorder, or condition for which it is desired to predict whether the subject will respond to the therapy. In an aspect, the disease, disorder, or condition may be an autoimmune disorder such as ulcerative colitis. The subject may be administered an anti-TNF therapy or an alternative to anti-TNF therapy based upon predictions provided by methods and systems described herein.

ANTI-TREM-1 ANTIBODIES AND USES THEREOF

NºPublicación:  US20260055183A1 26/02/2026
Solicitante: 
BRISTOL MYERS SQUIBB COMPANY [US]
BRISTOL-MYERS SQUIBB COMPANY
US_20260055183_PA

Resumen de: US20260055183A1

Provided herein are methods of identifying subjects suitable for an anti-TREM-1 antibody (i.e., antagonistic anti-TREM-1 antibody) treatment comprising measuring an expression level of a TREM-1 associated gene. Also disclosed herein are methods of determining efficacy of an anti-TREM-1 antibody comprising measuring an expression level of a TREM-1 associated gene. Methods of identifying non-responder to a standard of care treatment and methods of treating a disease or disorder (e.g., inflammatory bowel disease) with an anti-TREM-1 antibody are also disclosed.

METHOD, PROGRAM, AND APPARATUS FOR DETECTING SMALL INTESTINAL BACTERIAL OVERGROWTH

NºPublicación:  US20260053426A1 26/02/2026
Solicitante: 
ATMO BIOSCIENCES LTD [AU]
Atmo Biosciences Limited
US_20260053426_PA

Resumen de: US20260053426A1

Embodiments include a method for detecting small intestinal bacterial overgrowth, SIBO, the method comprising: obtaining data representing a time series of readings from gas sensor hardware housed within an ingestible capsule device orally ingested by a subject, identifying the data corresponding to timing of passage through the small intestine, and determining whether or not the data indicates presence of SIBO.

PREDICTING NON-RESPONSIVENESS OF IBD PATIENTS

NºPublicación:  EP4698905A1 25/02/2026
Solicitante: 
NAVOLAB DIAGNOSZTIKA KFT [HU]
Navolab Diagnosztika Kft
AU_2024260758_A1

Resumen de: AU2024260758A1

Predicting non-responsiveness of IBD patients The present invention relates to an in vitro method for predicting the responsiveness of an IBD patient to a therapy with an intracellularly acting immunosuppressive agent of interest, wherein a sample is provided from the IBD patient at an initial period of a treatment with the immunosuppressive agent of interest, said sample comprising effector mononuclear cells, and responsiveness is predicted from the difference between a multidrug ABC transporter activity level in the effector mononuclear cells in said sample and a reference transporter activity level. The method is useful in a treatment of IBD, e.g. in monitoring the progress of the disease or in a decision on a shift from an initial treatment with an agent to another agent like csDMARD or tsDMARD.

C4A3-HNE及びC4A4-HNEアッセイ

NºPublicación:  JP2026505763A 18/02/2026
Solicitante: 
ノルディック・ビオサイエンス・エー/エス
JP_2026505763_PA

Resumen de: AU2024213780A1

Disclosed herein are methods of immunoassay for detecting HNE-generated fragments of the α3 chain or α4 chain of type IV collagen in a patient sample, and the use thereof for detecting and/or monitoring inflammatory bowel disease (IBD) or a particular level of severity thereof in a patient. Also disclosed are monoclonal antibodies and assay kits for use in said methods of immunoassay.

潰瘍性大腸炎に関与する遺伝子の抗IL-23P19抗体調節

NºPublicación:  JP2026027222A 18/02/2026
Solicitante: 
イーライリリーアンドカンパニー
JP_2026027222_A

Resumen de: US2024254217A1

The present disclosure generally relates to methods of treating and diagnosing ulcerative colitis. The methods are particularly suitable for treating and diagnosing a specific sub-group of patients with ulcerative colitis. The methods are also particularly suitable for treating and diagnosing urgency in a patient having or suspected of having ulcerative colitis. The methods are also particularly suitable for treating and diagnosing stool frequency and bowel urgency in a patient having or suspected of having ulcerative colitis.

PROPHYLACTIC OR THERAPEUTIC AGENT FOR CROHN'S DISEASE AND METHOD FOR EXAMINING CROHN'S DISEASE

NºPublicación:  WO2026034527A1 12/02/2026
Solicitante: 
THE UNIV OF OSAKA [JP]
\u56FD\u7ACB\u5927\u5B66\u6CD5\u4EBA\u5927\u962A\u5927\u5B66
WO_2026034527_A1

Resumen de: WO2026034527A1

Provided are a prophylactic or therapeutic agent for Crohn's disease, and a method for examining Crohn's disease. The prophylactic or therapeutic agent for Crohn's disease contains at least one selected from the group consisting of a RUNX2 inhibitor and a BHLHE40 inhibitor. The method for examining Crohn's disease includes (1) a step for detecting a protein and/or mRNA of at least one gene selected from the group consisting of RUNX2 and BHLHE40 in digestive tract-derived immune cells collected from a subject.

METHODS OF CLASSIFYING AND TREATING INFLAMMATORY BOWEL DISEASE

NºPublicación:  EP4689191A2 11/02/2026
Solicitante: 
BAYLOR COLLEGE MEDICINE [US]
Baylor College of Medicine
WO_2024206308_PA

Resumen de: WO2024206308A2

Embodiments of the disclosure encompass methods and compositions for treating and/or identifying subjects having Inflammatory Bowel Disease (IBD). In certain embodiments, methods include measuring taxa occurrence frequencies in at least one microbiome sample from a subject suspected or having or being at risk for having IBD when certain taxa are enriched in the microbiome and/or when certain taxa are deficient in the microbiome, and particularly upon classification of their microbiome based on a taxa enrichment profile. In certain embodiments, an individual is determined to be a suitable donor for fecal microbiota transplant or is determined not to be a suitable donor for FMT based on classification of the taxa profile of their microbiome.

SMAD7 INHIBITORY ANTISENSE OLIGONUCLEOTIDES (ASO) FOR TREATING POUCHITIS AND METHODS OF USING THE SAME

NºPublicación:  EP4689108A1 11/02/2026
Solicitante: 
NOGRA PHARMA LTD [IE]
Nogra Pharma Limited
KR_20250164821_A

Resumen de: CN120958131A

Provided herein are methods for treating or preventing pouch inflammation comprising administering a SMAD7 antisense oligonucleotide or a pharmaceutical formulation comprising the SMAD7 antisense oligonucleotide.

METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST

NºPublicación:  ES3054955T3 09/02/2026
Solicitante: 
PML SCREENING LLC
UNIV PARIS SACLAY
THE ASSIST PUBLIQUE HOPITAUX DE PARIS APHP
THE INSTITUT NATIONAL DE LA SANTE ET DE LA RECH MEDICALE INSERM
PML Screening, LLC,
Universit\u00E9 Paris-Saclay,
The Assistance Publique-H\u00F4pitaux de Paris (APHP),
The Institut National de la Sant\u00E9 et de la Recherche M\u00E9dicale (INSERM)
US_2025277269_A1

Resumen de: US2025277269A1

This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

BIOMARKERS FOR DETERMINING TREATMENT OF ULCERATIVE COLITIS WITH FILGOTINIB

NºPublicación:  WO2026027669A1 05/02/2026
Solicitante: 
ALFASIGMA S P A [IT]
ALFASIGMA S.P.A
WO_2026027669_A1

Resumen de: WO2026027669A1

Filgotinib or a pharmaceutically acceptable salt thereof for use in a method of treating ulcerative colitis is provided, along with methods of deciding whether to continue treating ulcerative colitis in a patient with filgotinib or a pharmaceutically acceptable salt. The treatments are based on the assessment of the levels of certain predictive biomarkers in the patient having ulcerative colitis.

COMPOSITIONS AND METHODS TO DETECT GASTROINTESTINAL DISEASE

NºPublicación:  US20260036584A1 05/02/2026
Solicitante: 
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV AND AGRICULTURAL AND MECHANICAL COLLEGE [US]
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
US_20260036584_PA

Resumen de: US20260036584A1

This invention is directed to compositions and methods to detect and treat gastrointestinal diseases.

BIOMARKERS FOR DETERMINING TREATMENT OF ULCERATIVE COLITIS WITH FILGOTINIB

NºPublicación:  WO2026027676A1 05/02/2026
Solicitante: 
ALFASIGMA S P A [IT]
ALFASIGMA S.P.A
WO_2026027676_A1

Resumen de: WO2026027676A1

Filgotinib or a pharmaceutically acceptable salt thereof for use in a method of treating ulcerative colitis is provided, along with methods of deciding whether to continue treating ulcerative colitis in a patient with filgotinib or a pharmaceutically acceptable salt. The treatments are based on the assessment of the levels of certain predictive biomarkers in the patient having ulcerative colitis.

염증성 장 질환 (IBD)의 진단을 위한 방법 및 시스템

NºPublicación:  KR20260016998A 04/02/2026
Solicitante: 
디아소린이탈리아에스피에이
KR_20260016998_PA

Resumen de: MX2025014639A

The invention relates to a method and kit for the diagnosis of Inflammatory Bowel Disease (IBD) in a subject. The diagnostic method is based on the detection of fecal Calprotectin and at least one further fecal biomarker selected from PGRP-S and MMP-8 in a stool sample from the subject. In a preferred embodiment, the fecal biomarkers concentration data obtained are analyzed and classified as affected by IBD or not affected by IBD by a supervised machine learning diagnosis model.

METHOD AND SYSTEM FOR THE DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE (IBD)

NºPublicación:  MX2025014639A 03/02/2026
Solicitante: 
DIASORIN ITALIA S P A [IT]
DIASORIN ITALIA S.P.A
AU_2024283890_PA

Resumen de: MX2025014639A

The invention relates to a method and kit for the diagnosis of Inflammatory Bowel Disease (IBD) in a subject. The diagnostic method is based on the detection of fecal Calprotectin and at least one further fecal biomarker selected from PGRP-S and MMP-8 in a stool sample from the subject. In a preferred embodiment, the fecal biomarkers concentration data obtained are analyzed and classified as affected by IBD or not affected by IBD by a supervised machine learning diagnosis model.

Method and system for the diagnosis of inflammatory bowel disease (ibd)

NºPublicación:  IL325135A 01/02/2026
Solicitante: 
DIASORIN ITALIA S P A [IT]
CLAUDIA ZIEROLD
FABRIZIO BONELLI
MARIA ASSUNTA PALMIERI
CLAUDIO MASTRONARDO
DIASORIN ITALIA S.P.A,
Claudia ZIEROLD,
Fabrizio BONELLI,
Maria Assunta PALMIERI,
Claudio MASTRONARDO
AU_2024283890_PA

Resumen de: AU2024283890A1

The invention relates to a method and kit for the diagnosis of Inflammatory Bowel Disease (IBD) in a subject. The diagnostic method is based on the detection of fecal Calprotectin and at least one further fecal biomarker selected from PGRP-S and MMP-8 in a stool sample from the subject. In a preferred embodiment, the fecal biomarkers concentration data obtained are analyzed and classified as affected by IBD or not affected by IBD by a supervised machine learning diagnosis model.

CHEMICAL PROBES FOR MICROBIAL MUCIN DEGRADERS IN THE GUT MICROBIOME

NºPublicación:  WO2026024847A2 29/01/2026
Solicitante: 
BAYLOR UNIV [US]
BAYLOR UNIVERSITY
WO_2026024847_A2

Resumen de: WO2026024847A2

Affinity-based and activity-based probes (ABPs) described herein offer transformative resolutions to microbiome function. These ABPs target key metabolic pathways in the gut microbiome. The ABPs contain a binding group, a reactive group, and a. reporter group handle that allows for the addition of a "flexible" reporter group that can be easily swapped to enable multimodal fluorescence and proteomic measurements and isolation of live cells. The binding group, also called an affinity element or biorecognition element, mirrors monomeric and polymeric carbohydrates, sulfated and acetylated carbohydrates, and peptides to afford probe selectivity.

CCDC71L在诊断及治疗放射性肠炎中的应用

NºPublicación:  CN121380331A 23/01/2026
Solicitante: 
核工业四一六医院
CN_121380331_PA

Resumen de: CN119433017A

The invention discloses an application of CCDC71L in diagnosis and treatment of radiation enteritis, and provides an application of a reagent for detecting the expression level of the CCDC71L in preparation of a product for diagnosing radiation enteritis and an application of an inhibitor of the CCDC71L in preparation of a medicine for treating radiation enteritis. The invention further provides a method for screening candidate drugs for treating or preventing radiation enteritis and a method for inhibiting the expression level of inflammatory factors in macrophages. Experiments prove that the CCDC71L can realize diagnosis of radiation enteritis, and discovers that inhibition of the CCDC71L can inhibit infiltration and polarization of macrophages so as to inhibit radiation-induced inflammatory reaction, and the CCDC71L marker provided by the invention provides a new idea for diagnosis and treatment of radiation enteritis, and has a wide application prospect.

BACTERIOTHERAPY FOR CLOSTRIDIUM DIFFICILE COLITIS

NºPublicación:  ES3053646T3 23/01/2026
Solicitante: 
FERRING MICROBIOME INC
Ferring Microbiome Inc
EP_4663746_PA

Resumen de: EP4663746A2

This document discusses, among other things, receiving a plurality of donor fecal samples from a plurality of donors and storing and indexing each respective donor fecal samples using at least one characteristic of the respective donor fecal sample. In an example, the donor fecal sample can be screened and processed for subsequent use in fecal bacteriotherapy to displace pathogenic or undesired organisms in the digestive track of a patient with healthy or desirable gut micriobiota.

METHOD FOR MONITORING AND EVALUATION OF BOWEL HEALTH IN PREMATURE NEWBORNS

NºPublicación:  US20260022426A1 22/01/2026
Solicitante: 
CHOUTHAI NITIN SHASHIKANT [US]
Chouthai Nitin Shashikant
US_20260022426_A1

Resumen de: US20260022426A1

Disclosed is a method for monitoring and evaluation of bowel health in premature newborns. The method involves collecting stool/fecal samples from premature newborns/babies and processing the sample using microbiomics, automated cell counting, flowcytometry, and RT PCR analysis using specific gene signature or RNA transcriptomics analysis to determine risk of necrotizing enterocolitis. The method allows evaluation and tracking of gut health without needing to draw a blood test and is a non-invasive method. The method diagnoses and prevents bowel inflammation, infection and necrotizing enterocolitis (NEC) that facilitates initiation of prompt therapy to limit morbidity and mortality in premature babies. The method facilitates early management of signs of NEC thereby helping to save lives of premature babies and infants having low birth weight.

C3-HNE ASSAY

NºPublicación:  AU2024275955A1 22/01/2026
Solicitante: 
NORDIC BIOSCIENCE AS
NORDIC BIOSCIENCE A/S
AU_2024275955_A1

Resumen de: AU2024275955A1

The present invention relates to methods of immunoassay for detecting HNE-generated fragments of the α1 chain of type III collagen in a patient sample, and the use thereof for detecting and/or monitoring inflammatory bowel disease (IBD) or a particular level of severity thereof in a patient. The present invention also relates to monoclonal antibodies and assay kits for use in said methods of immunoassay.

SEROLOGY REPERTOIRE FOR THE DIAGNOSIS AND PROGNOSIS OF INFLAMMATORY BOWEL DISEASE

NºPublicación:  WO2026020057A1 22/01/2026
Solicitante: 
PROMETHEUS LABORATORIES INC [US]
PROMETHEUS LABORATORIES INC
WO_2026020057_PA

Resumen de: WO2026020057A1

This disclosure provides for method for the diagnosis, prognosis and treatment of inflammatory bowel disease (IBD) and clinical subtypes of IBD in a subject by detecting the presence or level of one or more immune responses to self and microbial antigens in a sample from a subject.

METHOD FOR DETERMINING INTESTINAL PERMEABILITY

NºPublicación:  EP4680971A1 21/01/2026
Solicitante: 
BIOMEDAL SL [ES]
Biomedal, SL
KR_20250158065_PA

Resumen de: CN120936879A

The present invention relates to an in vitro method for assessing the state of intestinal permeability in a subject and thus for diagnosing a disease or dysfunction associated with hyperintestinal permeability. More specifically, the procedure allows the amount of dietary antigens that can pass through the dysfunctional intestinal tract to be measured using common food components. The program allows for the development of analytical products and processes within the framework of the medical instrument industry.

C3-HNE 분석법

NºPublicación:  KR20260008782A 16/01/2026
Solicitante: 
노르딕바이오사이언스에이에스
AU_2024275955_A1

Resumen de: AU2024275955A1

The present invention relates to methods of immunoassay for detecting HNE-generated fragments of the α1 chain of type III collagen in a patient sample, and the use thereof for detecting and/or monitoring inflammatory bowel disease (IBD) or a particular level of severity thereof in a patient. The present invention also relates to monoclonal antibodies and assay kits for use in said methods of immunoassay.

METHOD AND SYSTEM FOR THE DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE (IBD)

Nº publicación: AU2024283890A1 15/01/2026

Solicitante:

DIASORIN ITALIA S P A
DIASORIN ITALIA S.P.A

AU_2024283890_PA

Resumen de: AU2024283890A1

The invention relates to a method and kit for the diagnosis of Inflammatory Bowel Disease (IBD) in a subject. The diagnostic method is based on the detection of fecal Calprotectin and at least one further fecal biomarker selected from PGRP-S and MMP-8 in a stool sample from the subject. In a preferred embodiment, the fecal biomarkers concentration data obtained are analyzed and classified as affected by IBD or not affected by IBD by a supervised machine learning diagnosis model.

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