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Preparation method and application of microalgae beta-1, 3-glucan-rosmarinic acid conjugate

NºPublicación:  CN120053675A 30/05/2025
Solicitante: 
OIL CROPS RES INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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CN_120053675_A

Resumen de: CN120053675A

The invention belongs to the technical field of functional component delivery system preparation, and particularly discloses a preparation method and application of a microalgae beta-1, 3-glucan-rosmarinic acid conjugate. According to the invention, beta-1, 3-glucan is extracted from microalgae Poterioochromonas malhamensis, and the beta-1, 3-glucan and rosmarinic acid are subjected to a simple esterification reaction to prepare the microalgae beta-1, 3-glucan-rosmarinic acid, so that the yield of the microalgae beta-1, 3-glucan-rosmarinic acid is increased, and the yield of the microalgae beta-1, 3-glucan-rosmarinic acid is increased. The microalgae beta-1, 3-glucan-rosmarinic acid conjugate can improve the antioxidant activity, anti-inflammatory activity and bioavailability of the rosmarinic acid, slow down the release speed of the rosmarinic acid in gastrointestinal tracts and improve the release and anti-cancer activity of the rosmarinic acid in colon.

Method for degrading new pollutants through co-culture of microalgae and graphene oxide

NºPublicación:  CN120058125A 30/05/2025
Solicitante: 
GUANGDONG UNIV OF TECHNOLOGY
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CN_120058125_PA

Resumen de: CN120058125A

The invention belongs to the field of environmental governance and biology, and provides a method for degrading new pollutants through co-culture of microalgae and graphene oxide, which comprises the following steps: S1, preparing graphene oxide through a Hummers method, and carrying out ultrasonic dispersion pretreatment; s2, carrying out expanding culture on freshwater algae, namely the clostridium clostridium, in an SE culture medium to a logarithmic phase, collecting algae cells, and adjusting the algae cells to target density; s3, mixing the graphene oxide prepared in the step S1 with the algae liquid in the step S2, and carrying out co-culture under the conditions of illumination and shaking table; s4, adding wastewater containing new pollutants into the co-culture system, and removing the pollutants through the synergistic effect of the adsorption effect of graphene oxide and the metabolic degradation effect of microalgae; s5, regularly sampling and analyzing the concentration change of the pollutants, and evaluating the degradation efficiency; according to the method disclosed by the invention, through co-culture of the graphene oxide and the acuminate clobetosa and the synergistic effect of GO adsorption and algae degradation, the pollutants are thoroughly mineralized, the removal efficiency of the refractory pollutants is remarkably improved, and the application range is widened.

Continuous flow two-stage microalgae biological carbon sequestration and product induction process based on intracellular nitrogen level regulation and control

NºPublicación:  CN120054212A 30/05/2025
Solicitante: 
TSINGHUA SHENZHEN INT GRADUATE SCHOOL
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CN_120054212_PA

Resumen de: CN120054212A

The invention relates to the field of sewage/wastewater treatment and biological carbon sequestration, in particular to a continuous flow two-stage microalgae biological carbon sequestration and product induction process, which comprises a culture pre-induction primary carbon sequestration stage and a product induction accumulation reinforced carbon sequestration stage. The method provided by the invention can solve the problems of long start delay period, slow biological accumulation rate, lack of directional induction regulation means and the like of traditional two-stage induction, and realizes efficient linkage of biological carbon fixation and carbon conversion. The process disclosed by the invention can be applied to deep denitrification in a water treatment process, is coupled with absorption and purification of flue gas and biogas CO2, and realizes fixed recovery and reutilization of carbon and nitrogen resources while carbon emission reduction is realized.

Feed additive for optimizing nutritional ingredients of poultry eggs

NºPublicación:  CN120052467A 30/05/2025
Solicitante: 
QINGDAO RES INSTITUTE CAS TECHNICAL PHYSICS
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CN_120052467_A

Resumen de: CN120052467A

The invention relates to a feed additive for optimizing nutritional ingredients of poultry eggs. The feed additive comprises natural grains, soybean flavone, lotus leaves, microalgae and a microalgae extract. The feed additive comprises the following raw materials in percentage by weight: 20-70% of corn, 5-10% of wheat bran, 5-10% of soybean meal, 2-5% of soybean isoflavone, 5-10% of lotus leaf powder, 10-20% of spirulina powder, 5-10% of chlorella powder and 5-20% of haematococcus pluvialis. The preparation method comprises the following steps: fully stirring and uniformly mixing the components, sub-packaging, adding into laying fowl feed according to the proportion of 1-2wt%, fully and uniformly mixing, feeding laying hens, and domesticating and feeding for 2-3 weeks to obtain eggs rich in nutritional ingredients such as proteins, flavonoid compounds, algae source carotenoids, vitamins, inorganic salts and the like. Compared with common eggs, the egg yolk cholesterol content can be reduced by more than 1/4; the egg white and the yolk are clear in boundary, the yolk is orange red, the fishy smell is obviously smaller than that of common eggs, and the yolk tastes fine and smooth; the obtained feed additive has a remarkable optimization effect on nutritional ingredients of poultry eggs, meanwhile, the taste and quality are improved, and economic benefits are increased.

Microalgae incubator

NºPublicación:  CN222923128U 30/05/2025
Solicitante: 
ARCHIMEDES GUANGZHOU COSMETICS RES CO LTD
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CN_222923128_U

Resumen de: CN222923128U

The utility model discloses a microalgae incubator and belongs to the technical field of incubators. The microalgae culture box comprises a box body, a containing cavity is formed in the box body, a plurality of partition plates are arranged in the box body at intervals in the first direction, and microalgae culture bottles are placed on the partition plates; the light source assembly is arranged on the side wall of the box body; the first pipeline assembly comprises a first main pipe and a plurality of first branch pipes, the plurality of first branch pipes are communicated with the first main pipe, one end of each first branch pipe is inserted into a culture solution of the microalgae culture bottle, and the first branch pipes are used for conveying carbon dioxide into the microalgae culture bottle; and the shaking table module is arranged at the bottom of the partition plate and is used for uniformly shaking the culture solution in the microalgae culture bottle. According to the utility model, the growth speed of the microalgae is increased, and the rapid cultivation of the microalgae is facilitated.

A METHOD OF PRODUCING KOMBUCHA WITH A HIGH CONTENT OF BIOACTIVE COMPOUNDS USING MICROALGAE DERIVATIVES

NºPublicación:  WO2025110939A1 30/05/2025
Solicitante: 
BURSA ULUDAG UENIVERSITESI [TR]
BURSA ULUDA\u011E \u00DCN\u0130VERS\u0130TES\u0130

Resumen de: WO2025110939A1

The invention relates to a novel food with high bioactive compound content that can be used in the food industry and to a production method. The invention particularly relates to a method of producing a new food with a high content of bioactive compound by using edible microalgae and / or microalgae derivatives and a food obtained by this production method. In the present invention, the said food is in particular a beverage, more particularly a Kombucha tea beverage.

Parasol-type streetlights for air purification using microalgae

NºPublicación:  KR20250075833A 29/05/2025
Solicitante: 
박소연

Resumen de: KR20250075833A

본 발명은 미세조류를 이용한 공기정화 파라솔형 가로등의 제작방법에 관한 것으로, 더욱 상세하게는 미세조류가 담겨있는 공기정화 파라솔형 가로등의 기둥 아래부분에 설치된 벤치와 파라솔을 고정시키고 LED를 달 수 있는 기둥 윗부분을 제작할 수 있는 제작 방법에 관한 것이다.이를 위하여 본 발명은 미세조류를 담을 수 있는 공기정화 파라솔형 가로등의 기둥과, 오염된 공기를 흡수함과 동시에 미세조류로 공급하는 에어 펌프가 설치된 발명품을 이용하는 시민들에게 편의를 제공할 수 있는 벤치, 파라솔을 고정하고 미세조류가 정화한 깨끗한 공기를 내보낼 수 있는 환기구가 달려 있으며 미세조류가 24시간 내내 오염된 공기를 정화할 수 있도록 LED를 달 수 있는 발명품의 윗부분으로 구성되어 있으며 세 부품을 모두 조립하여 미세조류를 담았을 때 공기 정화의 효력을 발휘한다는 점에 특징이 있다.

NOVEL SCHIZOCHYTRIUM SP. STRAIN AND METHOD FOR PRODUCING OIL CONTAINING OMEGA-3 USING SAME

NºPublicación:  EP4560005A1 28/05/2025
Solicitante: 
CJ CHEILJEDANG CORP [KR]
CJ Cheiljedang Corporation
EP_4560005_A1

Resumen de: EP4560005A1

A Schizochytrium sp. strain, which is a high-bio-oil-producing microalgae containing a high concentration of DHA, of the present invention, has high bio-oil productivity due to a high crude fat content in a produced biomass, and has the characteristic of containing a high content of docosahexaenoic acid within cells. Accordingly, the strain itself, a biomass produced by culturing and fermenting the strain, and its concentrates and extracts can be helpfully used as a feed composition or food composition.

Bacteria-algae co-immobilized material and application thereof in red tide treatment of prorocentrum donghaiense

NºPublicación:  CN120041432A 27/05/2025
Solicitante: 
FUZHOU UNIV
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CN_120041432_A

Resumen de: CN120041432A

The invention discloses a bacterium-alga co-immobilized material and application thereof in red tide treatment of prorocentrum donghaiense, and belongs to the field of microorganisms for harmful red tide treatment. According to the invention, alteromonas algicidal bacteria and autotrophic non-red-tide microalgae Tetraselmis are co-immobilized on the same carrier in an adsorption manner to form a bacteria-algae co-immobilized material. The bacterium-algae co-immobilization material has high algae-lysing performance on prorocentrum donghaiense red tide, the algae-lysing rate is 100% within 36 hours, and the algae-lysing rate is 84.07% after the bacterium-algae co-immobilization material is repeatedly used for four times. The bacteria-algae co-immobilized material has the characteristics of no toxicity, strong water absorption, high stability, reusability and the like, and can be effectively used for treating harmful algal blooms of red tide algae such as prorocentrum donghaiense.

Potamogeton malabaricus phyllosphere attachment bacterium ML5 with algae-lysing activity and application thereof

NºPublicación:  CN120041349A 27/05/2025
Solicitante: 
SHANGHAI OCEAN UNIV
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CN_120041349_PA

Resumen de: CN120041349A

The invention discloses potamogeton malabaricus phyllosphere attachment bacteria ML5 with algae-lysing activity and application of the potamogeton malabaricus phyllosphere attachment bacteria ML5, and belongs to the technical field of ecological microorganisms. The bacterium ML5 is named as Priesta aryabhattai ML5, the strain is preserved in Guangdong Province Microbial Culture Collection Center located at No.100, Xianlie Middle Road, Guangzhou City, Guangdong Province, the preservation number is GDMCC No: 65778, the preservation date is January 13, 2025, and the strain can be separated from potamogeton malabaricus phyllosphere. The invention further provides a microbial algicidal preparation containing the potamogeton malabaricus phyllosphere attached bacterium ML5. The method is used for biological prevention and control of freshwater cyanobacterial bloom, especially invasion cyanobacteria cuscuta larakii, and has a wide application prospect.

Novel schizochytrium sp. Strain and method for producing omega-3-containing oil using same

NºPublicación:  CN120051557A 27/05/2025
Solicitante: 
CJ CHEILJEDANG CORP
CJ\u7B2C\u4E00\u5236\u7CD6\u682A\u5F0F\u4F1A\u793E
CN_120051557_PA

Resumen de: CN120051557A

The Schizochytrium sp. Strain of the present invention is a high bio-oil-producing microalgae containing a high concentration of DHA, has high bio-oil productivity due to the high crude fat content in the produced biomass, and has the characteristic of containing a high content of docosahexaenoic acid in cells. Thus, the strain itself, biomass produced by culturing and fermenting the strain, and concentrates and extracts thereof can be advantageously used as a feed composition or a food composition.

Chlorella pyrenoidosa heterotrophic high-density proliferation method

NºPublicación:  CN120041365A 27/05/2025
Solicitante: 
OCEAN UNIV OF CHINA
WEIHAI DIPUSEN BIOTECHNOLOGY CO LTD
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\u5A01\u6D77\u8FEA\u666E\u68EE\u751F\u7269\u79D1\u6280\u6709\u9650\u516C\u53F8
CN_120041365_A

Resumen de: CN120041365A

The invention relates to the technical field of microalgae heterotrophic culture and biomass proliferation, in particular to a chlorella pyrenoidosa heterotrophic high-density proliferation method. The specific technical scheme is as follows: the heterotrophic high-density proliferation method of chlorella pyrenoidosa comprises the following steps: pre-culture and heterotrophic propagation of chlorella pyrenoidosa: inoculating a chlorella pyrenoidosa solution into a BG11 culture medium, and culturing for 3-4 days in a constant-temperature shaking table with the temperature of 25 +/-1 DEG C, the rotating speed of 200rpm and the light-dark ratio of 0h: 24h to obtain a primary culture chlorella solution; inoculating the primary culture algae liquid into a pre-sterilized and optimized heterotrophic culture medium, and carrying out expanding culture under the same culture condition for 3-4 days to obtain a secondary expanding culture algae liquid; (2) a heterotrophic high-density culture stage: regularly supplementing a nutrient culture medium containing high-concentration glucose, nitrate and phosphate by adopting an index fed-batch feeding strategy; other conditions are kept consistent during culture; and (3) an in-situ protein accumulation induction stage: when the chlorella pyrenoidosa reaches an exponential growth end stage, adding paclobutrazol into the system, and keeping other conditions consistent while keeping exponential fed-batch culture. According to the method disclo

Method for evaluating toxicity of organic pollutants to marine organisms

NºPublicación:  CN120041534A 27/05/2025
Solicitante: 
OCEAN UNIV OF CHINA
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CN_120041534_A

Resumen de: CN120041534A

The invention discloses a method for evaluating toxicity of organic pollutants to marine organisms, and belongs to the technical field of pollutant toxicity evaluation. According to the method for evaluating the toxicity of the organic pollutants to the marine organisms, three microalgae are adopted as biological models, the average toxicity value is obtained by integrating the growth dose-effect relationship of the three microalgae to evaluate the toxicity of the organic pollutants to be detected, and compared with single microalgae, the toxicity grade of the organic pollutants can be more comprehensively and effectively reflected; besides, non-linear least square fitting is carried out on concentration-inhibition rate data through two two-parameter non-linear functions Weibull and Logit, an optimal fitting function is judged according to a correction determination coefficient (R2adj) and an average absolute error (MAE), and the obtained half-inhibition concentration is more accurate. Therefore, the method provided by the invention is more real, comprehensive and accurate, and has important application value in the evaluation of the toxicity of the organic pollutants to the marine organisms.

Method for promoting microalgae carbon sequestration by amine degradation product based on amine method carbon capture

NºPublicación:  CN120041306A 27/05/2025
Solicitante: 
CHINA UNIV OF MINING AND TECHNOLOGY
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CN_120041306_PA

Resumen de: CN120041306A

The invention discloses a method for promoting microalgae carbon sequestration based on amine degradation products of amine method carbon capture. The method specifically comprises the following steps: (1) extracting and separating an amine degradation product; (2) adding the extracted amine degradation product into a microalgae culture solution; (3) inoculating microalgae into the culture solution containing the amine degradation product; (4) introducing flue gas CO2 into the culture solution, adjusting the pH value to 7-8, and stopping introducing gas; (5) when the pH value rises to 10-11, repeating the step (4) until the microalgae reach a mature period; and (6) harvesting a mature microalgae product. An amino functional group in the amine degradation product reacts with CO2, so that the mass transfer process of CO2 is enhanced; besides, most of amine degradation products are carboxylic acid amine salts, and as amphoteric compounds, the amine degradation products have a good pH buffering effect and can effectively reduce damage to microalgae cells in the high-concentration CO2 ventilation process. Meanwhile, the carboxylic acid amine salt is beneficial to hydrolysis of a product after CO2 is absorbed into inorganic carbonate, so that the carbon sequestration efficiency of the microalgae is remarkably improved.

Photocatalytic porous skeleton for microalgae carbon sequestration as well as preparation method and application of photocatalytic porous skeleton

NºPublicación:  CN120022953A 23/05/2025
Solicitante: 
CHANGAN UNIV
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CN_120022953_PA

Resumen de: CN120022953A

The invention belongs to the technical field of CO2 capture and utilization, and particularly relates to a photocatalytic porous skeleton for microalgae carbon sequestration and a preparation method and application thereof. The photocatalytic porous skeleton comprises a porous skeleton, and a carbon black layer, a carbon nanotube layer and a photocatalyst layer which are sequentially arranged on the porous skeleton, the porous framework is made of polyurethane sponge; the photocatalyst is g-C3N4/TiO2 (titanium dioxide). The photocatalytic porous skeleton prepared by the invention can obviously enhance the carbon sequestration effect of photosynthesis of microalgae, can double the CO2 removal rate of a column type microalgae photobioreactor with the capacity of 100L, and can convert captured CO2 into organic matters.

Micrococcus algal oil embedding method with starch base as wall material

NºPublicación:  CN120021775A 23/05/2025
Solicitante: 
GUANGXI ACAD OF SCIENCES
GUANGXI STATE FARMS MINGYANG BIOCHEMICAL CO LTD
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\u5E7F\u897F\u519C\u57A6\u660E\u9633\u751F\u5316\u6709\u9650\u516C\u53F8
CN_120021775_PA

Resumen de: CN120021775A

The invention discloses a method for embedding microalgae oil by taking a starch base as a wall material. The method comprises the following steps: weighing starch sodium octenylsuccinate, slowly adding the starch sodium octenylsuccinate into single distilled water, heating and stirring until the starch sodium octenylsuccinate is completely dissolved to obtain a water-phase solution; the preparation method comprises the following steps: weighing algae oil of micrococcus, absolute ethyl alcohol and fatty acid monoglyceride, mixing and stirring to obtain an oil phase solution; stirring the water phase solution under the condition that the speed is 10000 to 12000 r/min, then slowly adding the oil phase solution into the water phase solution, and then continuously stirring for 10 to 20 minutes to obtain an emulsion; freezing the emulsion at-80 DEG C for 12 hours, then carrying out vacuum freeze drying for 72 hours, then crushing to obtain microcapsule powder coated with micrococcus oil, and sealing and storing the microcapsule powder. According to the method, active substances of the micrococcus faecalis oil are not damaged, the embedding rate is good, a high-temperature environment is not used in the production process, operation is easy, and the method is suitable for large-scale processing and production.

Drilling fluid biotoxicity evaluation method based on microalgae rapid chlorophyll fluorescence

NºPublicación:  CN120026077A 23/05/2025
Solicitante: 
PETROCHINA COMPANY LTD
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CN_120026077_PA

Resumen de: CN120026077A

The invention discloses a drilling fluid biotoxicity evaluation method based on microalgae rapid chlorophyll fluorescence, and relates to the technical field of drilling fluid biotoxicity evaluation methods, the drilling fluid biotoxicity evaluation method comprises the following steps: S1, culturing microalgae in a photobioreactor, and activating and culturing the microalgae as a seed solution for later use; s2, taking the waste drilling fluid with different concentration gradients as experimental group culture conditions, setting a control group, and inoculating the control group into a photobioreactor filled with the seed solution for culture to obtain a culture system; s3, measuring Fv/Fm in rapid chlorophyll fluorescence parameters of the culture system; s4, calculating the inhibition ratio of the waste drilling fluid to the microalgae; s5, screening and determining the time required by the evaluation method; s6, EC50 of the concentrated control substance and EC50 of the waste drilling fluid are obtained according to the required time of the evaluation method, Fv/Fm in rapid chlorophyll fluorescence parameters is used as a detection index, the inhibition condition of microalgae can be more accurately represented, and the evaluation period is shortened.

METHOD FOR THE PRESERVATION OF MICROALGAL STRAINS IN A SEMI-SOLID MEDIUM (Machine-translation by Google Translate, not legally binding)

NºPublicación:  ES3020982A1 23/05/2025
Solicitante: 
UNIV ALMERIA [ES]
UNIV DEL PAIS VASCO / EUSKAL HERRIKO UNIBERTSITATEA [ES]
Universidad de Almer\u00EDa,
Universidad del Pa\u00EDs Vasco / Euskal Herriko Unibertsitatea
ES_3020982_PA

Resumen de: ES3020982A1

Method for the conservation of microalgal strains in a semi-solid medium. The present invention relates to a method for the medium- to long-term conservation of microalgal strains in a semi-solid medium. Advantageously, the method of the invention comprises carrying out the following steps: (a) providing a first culture vessel, where said vessel contains a semi-solid microalgal culture medium comprising an agar concentration between 0.1-1.0% v/v; (b) depositing a microalgal strain on the semi-solid microalgal culture medium; and (c) incubating the microalgal strain deposited on the semi-solid microalgal culture medium at a temperature between 15-30 ° C and under incident irradiation of {IMAGE-01} with a photoperiod of between 16:8 to 8:16 (light:dark) for a time between 7-30 days. (Machine-translation by Google Translate, not legally binding)

Composition for treating contaminated water containing microalgae as an active ingredient and its use

NºPublicación:  KR20250071912A 22/05/2025
Solicitante: 
경북대학교산학협력단
KR_20250071912_PA

Resumen de: KR20220152129A

The present invention provides an environmentally friendly water treatment method for treating polluted water including reverse osmosis concentrated water containing high nutrients, ions and metal elements through Chlorella spp. and Desmodesmus spp. that consume large amounts of nutrients very efficiently and grow rapidly under various sewage conditions, and at the same time manufacturing biofuel.

FOOD SUPPLEMENT

NºPublicación:  US2025161385A1 22/05/2025
Solicitante: 
ANKIRSKY MIKHAIL [US]
SOTNIKOV KONSTANTIN [KZ]
Ankirsky Mikhail,
Sotnikov Konstantin
US_2025161385_A1

Resumen de: US2025161385A1

A feed additive for farm animals and poultry is provided, including biomass and/or cultural liquid of the microalgae Chlorella vulgaris together with chlorellin in a titer of 108-1014 CFU per 1 ml of cultural liquid and/or biomass. Related methods are also provided.

METHODS AND COMPOSITIONS FOR TREATING SOIL AND PLANTS

NºPublicación:  US2025162956A1 22/05/2025
Solicitante: 
CORE INTELLECTUAL PROPERTIES HOLDINGS LLC [US]
Core Intellectual Properties Holdings, LLC
US_2024025816_A1

Resumen de: US2025162956A1

The present invention comprises methods and compositions comprising a microalgae consortium. A composition comprises at least one genera of microalgae flocculated by Paenibacillus polymyxa strain, Strain 2, deposited under the Budapest Treaty as ATCC Accession No. PTA-12841. Methods of treating the soil comprise adding a composition of the present invention to soil.

Microalgae culture device for strong light

NºPublicación:  CN222877916U 16/05/2025
Solicitante: 
TONGWEI AGRICULTURAL DEV CO LTD
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CN_222877916_U

Resumen de: CN222877916U

The utility model discloses a microalgae culture device for strong light, which belongs to the technical field of microalgae biology and comprises a light source system and a microalgae culture system, the light source system comprises a high-power LED lamp, a condenser, a light guide optical fiber and a light guide plate, and the high-power LED lamp converges light through the condenser and transmits the light to the light guide plate through the light guide optical fiber; and the light guide plate is arranged in the microalgae culture system. Microalgae liquid is placed in the cultivation device, the light source system provides strong light for the cultivation device, the high-power LED lamp gathers light through the condenser and transmits the light to the light guide plate through the light guide optical fiber, the light guide plate evenly disperses the light, light and heat are separated, only light is guided into the cultivation system, and the trouble of too high temperature is avoided. The device disclosed by the utility model can meet the production and application requirements of strong-light microalgae.

Floating algae culture device

NºPublicación:  CN222877925U 16/05/2025
Solicitante: 
TONGWEI AGRICULTURAL DEV CO LTD
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CN_222877925_U

Resumen de: CN222877925U

The utility model discloses a floating algae culture device, which belongs to the technical field of microalgae biology and comprises a floating component floating on a water body, a microalgae fixing part used for fixing microalgae is arranged in the floating component, a feed port is arranged on one side of the floating component and connected with a feed pump through a feed pipe, and a discharge port is arranged on the other side of the floating component and connected with the feed pump through a discharge pipe. The discharging port is connected with a discharging pipe, and a transparent protective film is arranged above the floating assembly. The floating assembly is placed in a water body, microalgae are attached to the microalgae fixing piece before production, then the feeding pump is started, waste water rich in nitrogen and phosphorus enters the floating assembly sequentially through the feeding pump, the feeding pipe and the feeding port, and the waste water is discharged back to the water body again through the discharging port and the discharging pipe after passing through the microalgae fixing piece attached with the microalgae. Nitrogen and phosphorus in the wastewater are absorbed by the microalgae, so that the production requirements of the microalgae can be met, and the wastewater can be treated; the device has the advantages that the occupied area is not wasted, the equipment investment is reduced and the like.

Microalgae exosome nano-particles for targeting liver cancer tissue and preparation method of micro-algae exosome nano-particles

NºPublicación:  CN120000611A 16/05/2025
Solicitante: 
THE FOURTH AFFILIATED HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE
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CN_120000611_PA

Resumen de: CN120000611A

The invention discloses a microalgae exosome nano-particle for targeting liver cancer tissue and a preparation method thereof, and belongs to the technical field of biomedical materials, the method comprises the following steps: (1) preparing a microalgae cell exosome by combining an ultracentrifugation method, an ultrafiltration method and a size exclusion method, microalgae cells being chlorella cells or synechocystis cells, and the particle size of the microalgae cell exosome being 30-150nm; and (2) loading an immune checkpoint inhibitor into the microalgae cell exosome by an electroporation method to obtain a drug-loaded microalgae exosome, and carrying out membrane fusion on a liver tumor cell membrane and the drug-loaded microalgae exosome to prepare the microalgae exosome nanoparticles targeting the liver cancer tissue. The prepared microalgae exosome nanoparticles have the advantages of good liver cancer tissue targeting property, good biological safety and exact and accurate drug curative effect, and have wide application prospects in tumor treatment.

Method for preserving microalgae plants

Nº publicación: CN120005729A 16/05/2025

Solicitante:

GUANGDONG OCEAN UNIV
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CN_120005729_PA

Resumen de: CN120005729A

The invention relates to the technical field of plant preservation, and discloses a method for preserving microalgae plants. The invention aims to improve the existing microalgae plant preservation method, especially the preservation method for bait microalgae, so as to solve the problems that the existing microalgae preservation time is short, nutritional ingredients are lost after preservation, the activity is reduced and the like. According to the microalgae preservation method, choline chloride is added to maintain the balance of a carbon source and a nitrogen source in a culture medium, nickel salt is added to promote the activity of algae photosynthetic pigments in a stable period, and the purpose of prolonging the preservation time and activity of algae is achieved. The microalgae preserved by the method disclosed by the invention can be preserved for a longer time on the premise of the same activity, and has higher activity on the premise of the same preservation time, and the activity of the microalgae preserved by the method is several times of that of microalgae preserved by a conventional method. The microalgae plant preservation method does not use toxic and expensive reagents, is environment-friendly, and can greatly promote the popularization and application of the microalgae industry.

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