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一种3D打印件微孔表面制造工艺及3D打印件

Resumen de: CN121295114A

本发明提出一种3D打印件微孔表面制造工艺及3D打印件，涉及表面处理领域；工艺包括：将3D打印件置于源极靶材制成的外罩内部构成空心阴极后整体置于直流脉冲等离子真空炉内，真空炉顶部设置有电源正极，外罩作为活性屏；在直流脉冲电源作用下放电启辉，并在活性屏和空心阴极效应增强下将源极靶材通过等离子形式轰击至高温的3D打印件表面，以便通过吸附和互扩散方式在3D打印件表面形成均匀分布的微孔结构和表面合金层。方案利用活性屏耦合空心阴极技术获得高密度、活性的等离子与高温的3D打印件表面碰撞实现离子的互扩散合金化，不仅将表面未充分熔合的粉末颗粒再次熔合，解决致敏问题，且在打印件表面获得微孔结构。

基于多重涂覆和UV固化工艺的组织黏附型软骨化双层人工耳廓材料及其制备方法

Resumen de: CN121288005A

本发明公开了一种基于多重涂覆与UV固化工艺的组织黏附型软骨化双层人工耳廓材料及其制备方法。方法包括：1）采用微流控‑浸渍技术制备负载Kartogenin的甲基丙烯酸化透明质酸（HAMA）微球；2）通过甲基丙烯酰化及羧酰亚胺偶合反应，合成兼具多巴胺功能与光交联能力的双改性HAMA‑DA；3）基于LiDAR与三维重建技术，通过光固化3D打印制备高保真人工耳廓模具；4）配制复合间充质干细胞与载药HAMA微球的甲基丙烯酸化明胶（GelMA）复合浆料；5）在模具表面依次多重涂覆丙三醇层、HAMA‑DA溶液层、GelMA复合浆料层和HAMA‑DA溶液层，过程中配合UV预固化和二次UV固化，制得具备湿态组织黏附性与软骨诱导潜能的双层耳廓结构。该体系为人工耳廓构建提供了先进的材料平台与工艺路径。

包含可生物降解聚合物的植入物、其制造方法及其组合物

Resumen de: TW202506210A

Provided is an implant, which comprises a first biodegradable polymer and a second biodegradable polymer, wherein the first biodegradable polymer comprises a copolymeric polyhydroxyalkanoate (PHA), and the copolymeric polyhydroxyalkanoate (PHA) comprises a repeat unit derived from 4-hydroxybutyrate (4-HB) in an amount of 0.1% by weight to 50% by weight based on the total weight of the copolymeric polyhydroxyalkanoate (PHA).

一种颌骨囊肿的根管冲洗治疗系统及制备方法

Resumen de: CN121287334A

本发明公开了一种颌骨囊肿的根管冲洗治疗系统及制备方法，颌骨囊肿的根管冲洗治疗系统包括冲洗治疗器，根管冲洗治疗系统包括用于嵌设在病牙内部的嵌设体，嵌设体包括固定部和与固定部连接的导向部；牙髓腔与根管通道连通。固定部用于嵌设在病牙的牙根部开设的根管通道上，固定部内形成有第一腔体，导向部内形成有第二腔体，第一腔体和第二腔体连通；导向部上开设有导向通孔，导向通孔与第二腔体连通，固定部与颌骨囊肿接触，以使冲洗治疗器穿过导向通孔、第二腔体和第一腔体与颌骨囊肿接触。本发明的有益效果是：冲洗治疗器穿过导向通孔可以直接作用于颌骨囊肿腔，避免在颌骨的其他位置开辟新的冲洗通路而造成损伤，冲洗治疗器穿过导向通孔，冲洗和给药目标明确，效率极高。

一种淀粉-壳聚糖复合凝胶材料及其制备方法和应用

Resumen de: CN121287922A

本发明属于功能性凝胶材料技术领域，公开了一种淀粉‑壳聚糖复合凝胶材料及其制备方法和应用。方法一：将氧化淀粉和矿物质离子溶液混合均匀，进行糊化处理，制得凝胶化浆料，所述凝胶化浆料中还含有壳聚糖；将所述凝胶化浆料进行热挤压3D打印，制得具有三维结构的淀粉‑壳聚糖复合凝胶材料；方法二：将氧化淀粉和矿物质离子溶液混合，进行糊化处理，制得凝胶化浆料；并配制壳聚糖浆料；将两种浆料通过双喷头交替进行热挤压3D打印，制得具有多层交替结构的淀粉‑壳聚糖复合凝胶材料。本发明工艺简单可控，制得的复合凝胶具有优异的胃部稳定性和肠道靶向性，能同步激活小肠细胞旁途径和结肠跨细胞途径双重吸收机制，显著提高镁的生物利用度。

一种基于金纳米夹层的表面合金微孔化方法及医用植入件

Resumen de: CN121295105A

本发明属于表面处理技术领域，公开了一种基于金纳米夹层的表面合金微孔化方法及医用植入件。所述方法包括：获取原工件；于所述原工件表面沉积一金薄膜以形成一中间工件；将所述中间工件置于等离子真空炉内；其中，加热台、活性屏与顶盖合围形成一空心阴极；所述活性屏及所述顶盖的材质均为靶材，中间工件则置于所述空心阴极内；对等离子真空炉依次抽真空、通入惰性气体后，打开直流脉冲电源进行等离子辉光放电，进而使来自靶材的等离子体对金薄膜进行轰击，并于中间工件表面形成第一合金簇及第二合金簇，第一合金簇与第二合金簇继续互相扩散以于原工件表面形成一具有微孔结构的表面合金层。本发明满足了医用植入件对表面合金化处理的应用需求。

具有多个曲率的弹性密封形成结构

Resumen de: EP4674457A2

The present invention relates to a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least an entrance of a patient's nares. The patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing. The patient interface comprises a plenum chamber at least partially forming a cavity pressurisable to a therapeutic pressure of at least 6 cmH2O above ambient air pressure. The plenum chamber includes a plenum chamber inlet port sized and structured to receive the flow of air at the therapeutic pressure for breathing by a patient. The patient interface further comprises a seal-forming structure having a textile membrane constructed and arranged to form a seal with a region of the patient's face surrounding the entrance to the patient's airways inferior to a nasal bridge region of the patient's face. Said textile membrane has at least one hole such that the flow of air at said therapeutic pressure is delivered to at least the entrance to the patient's nares. The seal-forming structure is constructed and arranged to maintain said therapeutic pressure in the cavity throughout the patient's respiratory cycle in use. The textile membrane comprises a first layer constructed

一种增材制造的生物型胫骨托假体及其制作方法

Resumen de: CN121287371A

本发明一种增材制造的生物型胫骨托假体及其制作方法，涉及一种人工膝关节假体技术领域。生物型胫骨托假体包括四种类型：生物型对称胫骨托、生物型对称无柄胫骨托、生物型解剖型胫骨托和生物型解剖型无柄胫骨托。假体主要由托体、多孔结构和堵销等组件构成，通过增材制造技术一体成型，确保精度和强度。多孔结构设计为非规则空间立体网格状，厚度为0.6‑1.6mm，用于促进骨小梁长入，实现生物固定。定位钉采用子弹头形设计，配有排气槽和缺口，简化安装并增强稳定性。制作方法包括设计建模、应力优化、增材制造及后处理步骤，假体采用钛合金材料，满足相关国际标准。本发明具有安装简易、固定可靠、骨长入效果好等优点。

一种用于屈光不正医学研究的小鼠头架构建方法及小鼠头架结构及其安装使用方法

Resumen de: CN121287355A

本发明涉及一种用于屈光不正医学研究的小鼠头架构建方法及小鼠头架结构及其安装使用方法，首先获取小鼠头颈部三维解剖学数据；基于该数据设计头部安装架和眼部实验架的三维模型，并采用增材制造工艺成型。小鼠头架包括头部安装架和眼部实验架，头部安装架设有头部夹孔和颈部套口；眼部实验架设有镜片支架，并连接头部安装架。将头部安装架套接于小鼠头颈部并用绳索固定；将屈光实验镜压入镜片支架中；可在维持头架固定的状态下，拆卸实验镜并通过实验通孔对眼部用药。本发明旨在克服目前的屈光不正实验研究中动物模型造模装置固定方式存在的创伤性大、操作复杂、稳定性差且难以配合眼部用药的技术难题。

CURABLE FORMULATIONS USABLE IN FORMING TRANSPARENT MATERIALS OR OBJECTS FEATURING HIGH MECHANICAL STRENGTH

Resumen de: WO2026009143A1

Curable formulations that provide, when hardened, transparent materials, and uses thereof, are provided. The curable formulations include two or more urethane (meth)acrylate materials which differ from one another at least by the number average molecular weight lower than 2000 grams/mol and/or the Tg, and optionally by the number of blocks and/or the NCO/OH ratio in the urethane (meth)acrylate material, and optionally a material or substance that is capable of interfering with the formation of micron-sized clusters in a hardened material formed of the formulations.

Implantable objects fabricated by additive manufacturing and methods of fabricating the same

Resumen de: AU2025275151A1

An implantable object 1000’ and a method 100 of fabricating an implantable object is disclosed. The method 100 comprises melting a powder 210 comprising at least nickel and titanium with an energy source 220 and iteratively forming a plurality of stacked metallic layers 330 from the melted powder using an additive manufacturing technique. The implantable object is biased to expand from a first configuration 501 to a second configuration 502 when at or above a transformation temperature. ec e c

CHEAP, PORTABLE, ELECTRICITY-FREE ELECTROPORATOR FOR GENE TRANSFER IN CELLS

Resumen de: WO2026010589A1

The invention is a cheap, portable, electricity-free electroporator for gene transfer in single cells. In order to transfer substances such as the gene DNA in cells, it generates electricity in during 20 microseconds in the range of about 200 volts to 5 kv. This causes a temporary opening of the cell pore in bacteria/cells and the targeted substance enters. The first part of the product: Cuvette holder: It is designed to hold the current electroporation cuvettes in a suitable size. The 2 copper connection cables from the piezoelectricity supply electricity to the cuvette. The second part of the product: Main case: It contains the 1st part of the product and also contains the piezoelectric system, cables, and button. It weighs approximately 30 grams and is a 3D printed single piece. Its dimensions are preferably 27 mm x 62 mm x 35 mm. The third part of the product: Button: Thanks to this button, electricity through piezo system is transferred to the cuvette with a single press.

3D PRINTED CITRATE-BASED SCAFFOLDS USING ADDITIVE TO IMPROVE PRINTABILITY

Resumen de: WO2026011060A1

A citrate composition is provided for use in 3D printing of end products, e.g., scaffolds. The disclosed composition incorporates water soluble salts and/or sugars into a pre-polymer to improve the viscosity for 3D printing, increase the porosity of the resulting scaffold, and improve the handling of the citrate based bioceramic compositions.

DENTAL PROSTHESIS OR TEETH-STRAIGHTENING DEVICE CONTINUOUS PRODUCTION PROCESS USING 3D PRINTER, AND DENTAL PROSTHESIS OR TEETH-STRAIGHTENING DEVICE MANUFACTURED USING CONTINUOUS PRODUCTION PROCESS

Resumen de: WO2026010233A1

The present invention relates to a dental prosthesis or teeth-straightening device continuous production process using a 3D printer, and to a dental prosthesis or a teeth-straightening device manufactured using the continuous production process. The present invention is for manufacturing a patient-customized dental prosthesis or teeth-straightening device by using 3D data on the oral structure of a patient, wherein a teeth-straightening device is manufactured using 3D printing, supporter separation, washing, post-curing, and heat treatment processes are performed in a continuous process, and the steps proceed by means of a robot without manual handling by a person during proceeding of the steps, thereby improving production efficiency and enabling defective products to be sorted out without additional equipment.

ADDITIVES FOR 3D PRINTING POLYMER RESINS

Resumen de: US2025346703A1

The present disclosure provides micelles comprising a plurality of block co-polymers, the micelle comprising (i) a core comprising at least a portion of a poly(alkyl acrylate) block of one or more of the block co-polymers; and (ii) an outer layer comprising at least a portion of a poly(aryl acrylate) block or a poly(aryl methacrylate) block of one or more of the block co-polymers. The present disclosure also includes polymer compositions, polymer films, and devices (e.g., orthodontic equipment) including the same. Methods for making and using micelles, polymer compositions, polymer films, and devices (e.g., orthodontic equipment) are also disclosed. Further provided herein are methods of producing polymer compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

CERAMIC VENEERS AND CONTINUOUS ADDITIVE MANUFACTURING METHOD FOR MAKING CERAMIC VENEERS

Resumen de: CN120857914A

The present disclosure provides a method of making a ceramic article. The method comprises (a) obtaining a photopolymerizable slurry or sol comprising a plurality of ceramic particles distributed in the photopolymerizable slurry or sol, and (b) continuously moving a build substrate through the photopolymerizable slurry or sol using actinic radiation, and selectively polymerizing the photopolymerizable slurry or sol to form a gelled article. The method further includes (c) extracting a solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a specific density. In addition, additive manufactured ceramic articles exhibiting specific density, opacity, or both are provided.

USE OF GELATIN IN A SUPPORT MATERIAL FOR EMBEDDED PRINTING

Resumen de: WO2024218352A1

The current invention pertains to a use of gelatin in a support material for embedded printing. The current invention furthermore pertains to a method for preparing a gelatin support material for embedded printing and a gelatin support material, optionally obtainable by the method. The invention furthermore pertains to a method for embedded printing using a gelatin support material. In the context of the invention, the gelatin has an average molecular weight of 50 - 250 kDa and preferably is in a fluid bulk, single-phase and non-crosslinked form.

NOZZLE PLATE, FLUID EJECTION HEAD, FLUID EJECTION DEVICE, AND MODIFYING METHOD OF NOZZLE PLATE

Resumen de: EP4674624A1

A nozzle plate (128) configured for a fluid ejection head (114), a fluid ejection head (114) containing the nozzle plate (128), a fluid ejection device (100) containing the fluid ejection head (114), and a method for modifying a nozzle plate (128) for a fluid ejection device (100) to reduce fluid flooding thereon are provided. The nozzle plate (128) includes a plurality of nozzle holes (126) therein, the nozzle plate (128) being attached to a flow feature layer (124) on a semiconductor substrate (116), and the nozzle plate (128) includes a first hydrophobic region (150, 176, 186) surrounding each of the plurality of nozzle holes (126), whereby the first hydrophobic region (150, 176, 186) is configured to reduce flooding of the nozzle plate (128).

BIOPRINTING METHODS AND SYSTEMS

Resumen de: MX2025010283A

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

ELASTOMERIC SEAL-FORMING STRUCTURE WITH MULTIPLE CURVATURES

Resumen de: EP4674457A2

The present invention relates to a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least an entrance of a patient's nares. The patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing. The patient interface comprises a plenum chamber at least partially forming a cavity pressurisable to a therapeutic pressure of at least 6 cmH2O above ambient air pressure. The plenum chamber includes a plenum chamber inlet port sized and structured to receive the flow of air at the therapeutic pressure for breathing by a patient. The patient interface further comprises a seal-forming structure having a textile membrane constructed and arranged to form a seal with a region of the patient's face surrounding the entrance to the patient's airways inferior to a nasal bridge region of the patient's face. Said textile membrane has at least one hole such that the flow of air at said therapeutic pressure is delivered to at least the entrance to the patient's nares. The seal-forming structure is constructed and arranged to maintain said therapeutic pressure in the cavity throughout the patient's respiratory cycle in use. The textile membrane comprises a first layer constructed

一种光固化3D打印用硅酸钙基生物活性陶瓷浆料及其制备方法

Resumen de: CN121265855A

本发明涉及生物医用材料增材制造技术领域，具体涉及一种光固化3D打印用硅酸钙基生物活性陶瓷浆料及其制备方法。该浆料由以下质量份的原料组成：硅酸钙基生物陶瓷粉末50‑70份、活性单体15‑30份、低聚物8‑15份、光引发剂0.5‑2.5份、润湿分散剂1‑3份、流平剂0.5‑2份。本发明通过选用具有特定形貌和粒径分布的硅酸钙基陶瓷粉末，成功解决了生物陶瓷浆料因密度大、表面极性高而导致的易沉降、粘度高、固化层脆性大等问题。所制备的浆料具有生物活性高、粘度适宜、稳定性佳、固化后生坯强度高及打印精度好等特点，特别适用于制备具有复杂多孔结构的骨修复支架，经打印、清洗、烧结后，可获得力学性能良好、降解速率可控且具有优异生物活性的陶瓷构件。

Ag-DCPD膜层表面涂覆掺杂Ca-Cur亚微米改性材料的PLA层的方法

Resumen de: CN121265874A

本发明公开了一种Ag‑DCPD膜层表面涂覆掺杂Ca‑Cur亚微米改性材料的PLA层的方法，涉及医用材料表面生物涂层技术领域。该方法包括：采用激光粉末床熔融增材制造技术制造LPBF‑NiTi合金基体并进行预处理；将预处理后的LPBF‑NiTi合金基体在电解质溶液中进行电化学沉积，得到沉积Ag‑DCPD膜层的LPBF‑NiTi合金基体；将CaCl2和姜黄素溶于无水乙醇，放入放有(NH4)2CO3的密闭容器恒温反应，得到Ca‑Cur亚微米改性材料；将聚乳酸溶于二氯甲烷，后将Ca‑Cur亚微米改性材料分散其中，得到浸提液；将沉积Ag‑DCPD膜层的LPBF‑NiTi合金基体在浸提液中反复浸渍提拉，得到涂覆Ag‑DCPD/PLA/Ca‑Cur复合膜层的LPBF‑NiTi合金基体。通过本发明，成功改善了Ag‑DCPD膜层的耐蚀性、生物相容性及抑菌抗炎性能。

一种基于3D打印技术的尼古丁分级释放口含制剂及其制备方法

Resumen de: CN121264688A

本发明涉及一种基于3D打印技术的尼古丁分级释放口含制剂及其制备方法。所述尼古丁分级释放口含制剂为球状结构，由内至外依次仅包含长效核心层、缓释中间层和速释表层，三层通过3D打印技术一体成型；所述长效核心层、缓释中间层和速释表层均包括负载活性组分的多孔载体；且长效核心层、缓释中间层和速释表层中多孔载体的孔径依次增加；所述活性组分选自尼古丁、或其异构体、或其药学上可接受的盐。本发明通过3D打印技术实现了尼古丁三级释放的精准调控，实现了“快速起效‑持续维持‑长效收尾”的三级释放模式，起效快，满足感强，低剂量长效维持，尼古丁摄入不易过量，同时能够减少刺激性，且制备得到的口含制剂具有优异的储存稳定性。

一种基于水-水乳浊液的3D打印多孔水凝胶及其制备方法和应用

Resumen de: CN121270960A

本发明涉及一种基于水‑水乳浊液的3D打印多孔水凝胶及其制备方法和应用，涉及生物医学技术领域。是通过水凝胶前驱体经过光固化交联形成，水凝胶前驱体包括连续相介质和分散相介质，连续相介质和分散相介质的体积比为1:（2～5）。本申请提供的水凝胶突破连续相介质和分散相介质常规的体积比，打破了传统水‑水两相乳浊液带来的体积比例限制，制备而成的水凝胶具备多层级孔径，并且水凝胶的光固化成型性能、3D打印成型性能、溶胀性能及力学性能均优于现有通过高体积连续相介质制备而成的水凝胶，从而为制备更高孔隙及连通性的水凝胶提供了新的技术体系。

用于纠正替牙期单侧正锁合的3D打印矫治装置

Nº publicación: CN121265289A 06/01/2026

Solicitante:

南方医科大学口腔医院（广东省口腔医院、广东省牙病防治指导中心、广东省口腔医学研究院）

Resumen de: CN121265289A

本发明公开了一种用于纠正替牙期单侧正锁合的3D打印矫治装置，包括上颌矫治组件和下颌矫治组件；上颌矫治组件包括适配于正锁合侧牙列的3D打印金属联冠、适配于非正锁合侧及腭侧的树脂基托、以及连接3D打印金属联冠与树脂基托的螺旋扩弓器，螺旋扩弓器被配置为对正锁合侧牙列施加缩弓力；下颌矫治组件包括下颌3D打印金属支架和下颌树脂固位层，下颌3D打印金属支架在非正锁合侧形成金属带环结构，在正锁合侧延伸形成长臂钩结构，下颌树脂固位层包覆于所述金属带环结构的外表面及非正锁合侧牙齿表面。本发明利用数字化设计与3D打印技术定制，通过粘接剂固定于口内，具有固位力好、体积小、对患者依从性低、能有效防止后牙伸长及缩短治疗周期的特点。