Resumen de: CN121379984A
The invention belongs to the technical field of microorganisms, and discloses a salmonella enteritidis bacteriophage PC571, a bacteriophage composition thereof and application of the bacteriophage PC571, the preservation number of the bacteriophage PC571 is CGMCC No.46168, and the bacteriophage PC571 is preserved in China General Microbiological Culture Collection Center on August 16, 2024. The salmonella enteritidis bacteriophage PC571 is wide in splitting spectrum, has good splitting capability on salmonella bacteriophage resistant bacteria, and can cooperate with other existing salmonella bacteriophages for bacteriostasis. The salmonella enteritidis bacteriophage PC571 or the bacteriophage composition thereof can be used as an active ingredient to prepare a pharmaceutical preparation, an environmental disinfectant, a bacteriostatic agent, a detection kit and the like for application. The salmonellosis in a livestock farm can be purified by mixing the phage with water and feed for a long time, and in addition, the phage is relatively high in safety, can effectively prevent and treat infection of salmonella with phage resistance, and has a market application prospect.
Resumen de: CN121380278A
The invention discloses a salmonella sodium hypochlorite tolerance evaluation method, which comprises: (1) preparing a bacterial liquid, and (2) carrying out a cell viability chromogenic reaction: adding 100 mu L of a bacterial suspension and 100 mu L of a sodium hypochlorite solution with a gradient concentration into each well of a 96-well plate, standing for 30 min under a room temperature condition, adding 20 mu L of a 2.5 wt% sodium thiosulfate solution, standing for 10 min under a room temperature condition, and carrying out a cell viability chromogenic reaction, adding 20 mu L of a 10 * resazurin indicator, and culturing at a constant temperature of 37 DEG C for 4 h; and (3) salmonella tolerance grade determination based on the MIC value: taking the lowest sodium hypochlorite concentration of blue pores in a 96-pore plate as the MIC value, and the higher the MIC value is, the stronger the tolerance is. According to the method, the tolerance of the salmonella to the sodium hypochlorite can be intuitively and quickly judged through the chromogenic reaction.
Resumen de: WO2025003117A1
The present invention relates to a gelled reaction medium for detecting, identifying, and/or isolating at least one Shiga toxin-producing strain of E. coli, the reaction medium comprising: - at least one toxin inducer, - at least one agglutinating conjugate comprising at least one specific binding partner of STX1 and/or at least one specific binding partner of STX2, coupled to a nanoparticle; - a concentration gradient of a compound for inhibiting non-target bacteria. The present invention also relates to the associated method for detecting and/or isolating Shiga toxin-producing E. coli which is likely to be present in a sample comprising enterobacteria.
Resumen de: CN120917035A
The present invention relates to protein bacteriocins (PBs) as therapeutic agents, and in particular to protein complexes comprising two or more PB molecules associated with a protein scaffold comprising a homologous immune protein domain against an effector portion of the corresponding PB. In particular, the present invention provides an antibacterial protein complex comprising: (a) a first PB molecule and a second PB molecule; and (b) an immune protein scaffold comprising a first immune protein domain and a second immune protein domain; wherein the first immune protein domain and the second immune protein domain are non-covalently bound to the first PB molecule and the second PB molecule, respectively.
Resumen de: US20260022390A1
The present disclosure relates to a recombinant expression vector for secretion of melittin and an attenuated Salmonella strain transformed therewith, and provides an attenuated Salmonella strain transformed with a recombinant expression vector including an flgM gene and a melittin gene, an anticancer pharmaceutical composition including the attenuated Salmonella strain as an active ingredient, and a recombinant expression vector capable of improving the secretion ability of melittin.
Resumen de: US20260021146A1
The present disclosure relates to a recombinant expression vector for secretion of a VC1 protein and an attenuated Salmonella strain transformed therewith, and provides: a recombinant expression vector comprising an flgM gene, a VC1 gene, and an flhDC gene; an attenuated Salmonella strain transformed therewith; and a pharmaceutical composition for cancer treatment, comprising the attenuated Salmonella strain.
Resumen de: US20260022888A1
The purpose of the (Fort's Gloves, Dry and Hold Pail) is to prevent moisture that causes the spread of bacteria from restrooms that is the cause of influenza, streptococcus, E coli, Hepatitis, MRSA, Salmonella, Shigella, and Norovirus. The pail is a new creation except for the authentic manuscript and cursive text. There is a distinct difference from the usual and traditional utility pails each community uses, because of the holder for the moisture elimination products that prevents contaminated water from spilling to the floor. Fecal and Trash water could potentially cause mildew growth on the gloves and the pail. The Dry & Hold container overall is a new Invention and a cleaner choice for the environment because the design prevents disease, foul odors.
Nº publicación: EP4680273A1 21/01/2026
Solicitante:
AFFINIVAX INC [US]
Affinivax, Inc
Resumen de: CN120826235A
Techniques for providing immunogenic compositions (e.g., vaccines) and methods of inducing an immune response in a subject in need thereof are provided.