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98
resultados
Última actualización
04/05/2025 [07:13:00]
Resultados 75 a 98 de 98
Resumen de: CN119424475A
The invention discloses a self-assembly preparation method and application of multi-enzyme active nano-zinc oxide for treating salmonella enteritis, a trace amount of oleylamine is added as a protective agent, a self-assembly nano-enzyme is synthesized by a simple method, and the direct antibacterial effect of ZnO is improved; the minimal inhibitory concentration of ZnO synthesized by the same method in vitro is 250 mu g/mL, the minimal inhibitory concentration of ZnO doped with trace Cu and Mn is about 30 mu g/mL, and the bacteriostatic efficiency is improved by about 8 times; trace elements of copper (Cu) and manganese (Mn) are doped into a ZnO nano material, so that the ZnO nano material is endowed with various enzyme activities, peroxidase activity is exerted under the acidic condition of the stomach to generate bactericidal active oxygen, and superoxide dismutase and catalase activity for resisting oxidative stress are exerted when the ZnO nano material reaches neutral intestinal tracts, so that inflammation of the intestinal tracts is relieved; the traditional Chinese medicine composition can play a role in the acidic state of the stomach, can relieve inflammation of the intestinal tract in the intestinal tract, and can completely adapt to the environment of the gastrointestinal tract.
Resumen de: CN119433058A
本发明公开了一种基于纳米透镜高信噪比全息成像的数字化分析方法及系统，属于生化分析领域。本发明将微球纳米探针与高信噪比全息显微成像技术相结合，通过系列生化反应改变上清液/免疫复合物中微球信号探针的数量，磁分离后对上清液中PS微球纳米探针进行高信噪比全息成像；全息成像过程中利用声表面波‑叉指换能器驱动形成纳米透镜的高信噪比无透镜全息显微镜；利用轻量化的无监督学习目标检测算法获取全息图像中微球信号探针的数量，最终实现待测目标物的精准定量检测。实验结果表明，本发明有效地提升了检测灵敏度和效率，同时提高了检测准确率。
Resumen de: CN119432774A
The invention belongs to the technical field of microorganisms, and particularly relates to a bacteriophage for splitting bovine-derived salmonella and application of the bacteriophage. The technical problem to be solved by the invention is to provide a new choice for treating infection of bovine-derived salmonella. According to the technical scheme, the invention relates to a bacteriophage Seoulvirus GX2401 for splitting bovine-derived salmonella, wherein the preservation number of the bacteriophage Seoulvirus GX2401 is CCTCC (China Center for Type Culture Collection) NO: M20241156. The bacteriophage is a wide host spectrum thallus, can split six different salmonella, has a wide antibacterial spectrum, and can be applied to preparation of drugs for preventing and treating bovine salmonella infection diseases.
Resumen de: CN119431493A
本发明属于有机合成技术及生物发酵领域，具体涉及一种识别特意性肠道菌的肽探针及其制备方法。本发明公开制备的FITC‑AR‑9可以将AR‑9这种活性肽与肠道细菌的结合可视化，不仅能有效地提高检测的灵敏度和准确性，还可以缩短检测周期，降低检测难度，在未来有可能成为检测肠道菌能否利用活性肽的一种重要手段。
Resumen de: CN119432860A
本发明公开了一种检测肠炎沙门氏菌的试剂盒及其应用，属于生物分子检测技术领域。该试剂盒包括如下成分：核苷酸序列如SEQ ID NO.1所示的变构适配体探针、核苷酸序列如SEQ ID NO.3所示的模板链和核苷酸序列如SEQ ID NO.4所示的荧光报告探针。本发明试剂盒能将肠炎沙门氏菌同其他的杂质区分开，特异性强；可以得到可视化的荧光信号，易于判读；可以使模板链在反应中循环利用等温扩增产生Trigger链引导TtAgo蛋白高效、特异切割荧光报告探针，增大输出信号，且检测时间短，检测限低，灵敏度高，特异性好，具备实际推广应用前景。
Resumen de: CN119433064A
The invention belongs to the field of molecular biological detection, particularly relates to detection of salmonella paratyphi, and more particularly relates to detection of salmonella paratyphi A, salmonella paratyphi B and salmonella paratyphi C. The composition provided by the invention can specifically detect salmonella paratyphi only by detecting one target spot, the operation is simple, non-specific amplification does not exist, and particularly, salmonella paratyphi can be accurately distinguished from some genetically similar bacteria genus. And the sensitivity reaches 500 copies/mL, the detection is more accurate, a relatively sufficient basis for rapidly detecting and excluding infection of different pathogens can be provided, the detection time of the salmonella paratyphi is shortened, and the implementation of countermeasures is accelerated.
Resumen de: US2025051300A1
Small molecule inhibitors of the localization of lipoprotein CDE (LolCDE) complex that is found in the membrane of bacteria. Searches for suitable candidates for the LolCDE complex led to the discovery of an inhibitor named lolamycin. Lolamycin specifically targets Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Salmonella typhimurium, and is selective over Gram-negative and Gram-positive commensal bacteria, thereby avoiding perturbation of the gut microbiome.
Resumen de: CN119410591A
The invention belongs to the technical field of microbiology and agricultural application thereof, and particularly relates to a salmonella bacteriophage, a microbial preparation and application of the salmonella bacteriophage. The salmonella bacteriophage disclosed by the invention belongs to a long-tail bacteriophage, has relatively good killing and destroying capability on host bacteria drug-resistant salmonella typhimurium SB56, also can have different degrees of splitting action on other 16 clinical drug-resistant salmonella typhimurium, is relatively wide in antibacterial spectrum, and has the potential of being applied to drugs for preventing and treating salmonella typhimurium; the salmonella bacteriophage pSty.S56. XXXSZ disclosed by the invention is relatively short in latency period and relatively strong in environmental tolerance, and can achieve a synergistic effect with antibiotics, so that the antibacterial ability is relatively lasting, and the dosage of avidin is reduced.
Resumen de: CN119410590A
The invention relates to a salmonella enteritidis bacteriophage, which is named as PAC/QD23121802, and the preservation number of the salmonella enteritidis bacteriophage is CGMCC No.46089. The salmonella enteritidis bacteriophage PAC/QD23121802 is in the form that the head part is of a 24-face structure, the length of the head part is 750-800nm, and the length of the tail part is 300-350nm. The invention also discloses a salmonella bacteriophage composition, wherein the salmonella bacteriophage composition contains the salmonella bacteriophage PAC/QD23121802 and the salmonella bacteriophage PAC/QD23120510. The invention also discloses a salmonella bacteriophage composition, the composition has wide spectrum, experimental data show that the composition can kill 100% salmonella enteritidis, and the bacteriophage composition has the advantage of enhancing the treatment effect of the bacteriophage. The genomes of the bacteriophage of the composition do not carry virulence genes, drug-resistant genes and lysogenic genes, so that the transmission of the virulence genes and the drug-resistant genes is not caused, and the use is safe.
Resumen de: CN119409809A
本发明公开了一种用于检测鼠伤寒沙门氏菌的纳米抗体，旨在提供一种检测准确度高，特异性强，获得方法简单的用于检测鼠伤寒沙门氏菌的纳米抗体；所述纳米抗体氨基酸序列如SEQ‑Styp NO.1、SEQ‑Styp NO.2、SEQ‑Styp NO.3和SEQ‑Styp NO.4所示；属于生物检测技术领域。
Resumen de: CN119410687A
本发明提供了一种提供鼠伤寒沙门菌ArcB基因缺失株及其构建方法和应用，属于基因工程技术领域。本发明的构建方法包括：扩增出打靶DNA；将pKD46质粒电转进SL1344感受态细胞中，再将打靶DNA电转入含有pKD46质粒的SL1344中，获得含Kan抗性基因的缺失株；将pCP20质粒电转入含kan抗性基因的缺失株后，消除pCP20质粒；测序无误后即获得ArcB基因缺失株SL1344ΔArcB。本发明提供的SL1344ΔArcB的抗酸、抗高渗能力比WT显著减弱，对青霉素、亚胺培南、卡那霉素和阿米卡星敏感性显著上升，庆大霉素敏感性显著下降，对鼠伤寒沙门菌耐药、毒力及疫苗等方面的研究具有重要意义。
Resumen de: CN119410559A
The invention discloses bifidobacterium breve with hypoglycemic capacity and application, a product and a method thereof, and belongs to the technical field of microorganisms. The invention provides a bifidobacterium breve (Bifidobacterium breve) strain BBr37 with the blood sugar reducing capacity, and the preservation number of the bifidobacterium breve strain BBr37 is CGMCC (China General Microbiological Culture Collection Center) NO.32423. The invention also provides an application of the strain BBr37 in preparation of hypoglycemic drugs or health-care foods with an auxiliary hypoglycemic function or bacteriostatic agents or non-treatment-destination bacteriostasis, and a product and a method based on the strain BBr37. The strain BBr37 disclosed by the invention has a relatively strong inhibition effect on escherichia coli, staphylococcus aureus, salmonella, haemophilus parasuis, haemophilus parainfluenza, campylobacter jejuni and enterocolitis yarrowia, and can effectively achieve the effects of reducing blood sugar and regulating intestinal flora.
Resumen de: CN119388390A
The invention provides a preparation method of a sheet-shaped micro-robot with a sandwich structure and a precise operation system. The method comprises the following steps: obtaining a silicon wafer provided with a sheet-shaped porous diatom shell sheet, carrying out film coating treatment on the silicon wafer, and carrying out micro-operation on the silicon wafer to separate the diatom micro-robot. Natural diatomite is used as a template, the diatomite-based heterogeneous magnetic microrobot is constructed, efficient capture and detection of salmonella are realized through a unique three-dimensional porous structure and a motion mode of the diatomite-based heterogeneous magnetic microrobot, and the diatomite-based heterogeneous magnetic microrobot has extremely high application value and research potential; according to the system, accurate control over multiple motion modes of the micro robot can be achieved.
Resumen de: CN119385150A
The invention discloses application of DNA-silver nanoclusters in resisting salmonella, and belongs to the technical field of antibiosis. According to the invention, DNA with a hairpin structure is used as a template, and the DNA and silver nitrate form the DNA-silver nanocluster. The DNA-silver nanocluster obtained by the method disclosed by the invention has more remarkable bacteriostatic and bactericidal effects; in addition, the hairpin DNA-silver nanocluster disclosed by the invention has relatively high biocompatibility, is not easy to cause the drug resistance of salmonella, and can be used for preparing antibacterial drugs.
Resumen de: CN119395116A
本发明属于纳米生物传感器领域，公开了一种用于大肠杆菌检测的硅‑金‑适配体纳米线阵列的原位制备方法，在硅片上使用原位合成法制得的纳米线阵列材料，在纳米线阵列上化学还原法原位负载金纳米颗粒与大肠杆菌适配体，在硅片的背面镀金属膜，使用时将此面与电路连接，使硅‑金‑适配体纳米线阵列在测试中产生的电信号通过硅片的传导输入电路。大肠杆菌适配体可将测试液中的大肠杆菌特异性地吸附于材料表面并产生与菌液浓度线性相关的电流响应，原位合成的纳米阵列结构的电极的巨大表面积使传感器具有良好的灵敏度。这种高性能纳米生物传感器为食源性致病菌的现场快速检测提供了具有实用性的新方法。
Resumen de: CN119391883A
The invention discloses a primer group for simultaneously detecting seven pet enteropathogenic bacteria and application thereof, the primer group comprises primer sequences as shown in SEQ ID NO: 1-14, and the seven pet enteropathogenic bacteria are hemorrhagic escherichia coli, salmonella enteritidis, campylobacter jejuni, clostridium difficile, clostridium perfringens, yersinia enteritidis and staphylococcus aureus. Extracting DNA (Deoxyribonucleic Acid) of a sample to be detected by using the excrement sample nucleic acid extraction kit; taking the sample DNA as a template, carrying out multiple PCR reaction by using the primer group to obtain an amplification curve, and if the Ct value of the amplification curve of the sample to be detected is 0 amp, detecting the Ct value of the sample to be detected; lt; c < tamp >; lt; 30, and the Ct value of the IPC is amp; lt; and 40, determining that the interpretation result is positive, and indicating that the sample to be detected contains the one or more enteropathogenic bacteria. According to the invention, a primer sequence with high sensitivity and specificity is adopted, so that the quality of a detection result is ensured; the detection method is simple to operate, time-saving and labor-saving; the detection flux is high, and the reagent consumable cost is low.
Resumen de: WO2025026111A1
A neutrophil loaded with attenuated salmonella and a preparation method therefor and a use thereof, relating to the technical field of biology. Vascular clearance by a neutrophil is a key factor affecting the tumor colonization rate of oncolytic bacteria, i.e., attenuated salmonella typhimurium. The neutrophil can be recruited to a tumor microenvironment after being loaded with the oncolytic bacteria, so that the tumor colonization rate and tumor targeting performance of the bacteria are effectively improved. The neutrophil can directly kill tumor cells and release intracellular oncolytic bacteria to induce an anti-tumor immune response, thereby effectively inhibiting the progression of pulmonary metastases from melanoma.
Resumen de: AU2023323947A1
The invention is directed to immunogenic compositions and method of treatment comprising a peptide or nucleic acid that encodes the peptide that induces an immune response in a mammal that is protective against infection by one or more pathogens. The peptide sequence contains multiple epitopes, wherein at least one epitope is a composite epitope which is a combination of two or more conserved epitopes of the pathogen wherein the amino acid sequence of the composite is not an amino acid sequence of the pathogen. In addition, the invention is directed to vaccines comprising the peptide or nucleic acid that encodes the peptide for treating and preventing an infection in mammals such as animals and humans.
Resumen de: US2025043231A1
An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses.
Resumen de: US2025041355A1
The present invention relates to a pharmaceutical composition for preventing or treating cancer comprising a Salmonella strain and an immune checkpoint inhibitor as active ingredients. The composition of the present invention may be useful as a prophylactic or therapeutic composition of improving the survival rate by significantly reducing the tumor size by co-administering bacteria and an immune checkpoint inhibitor in cancer, especially a type of cancer that is resistant and difficult to treat by a single anticancer therapy.
Resumen de: US2025044289A1
Provided herein are molecularly imprinted polymer (MIP) coated articles, sensors comprising polymer (MIP) coated articles, methods of manufacture and uses thereof.
Resumen de: WO2023183598A1
This disclosure relates to methods of isolating rare or non-dominant serotypes of Salmonella species from a sample. The disclosure further relates to the isolation of non-dominant serotypes of Salmonella in a sample related to one or more products for human or animal consumption.
Nº publicación: EP4499805A1 05/02/2025
Solicitante:
UNIV MASSACHUSETTS [US]
University of Massachusetts
Resumen de: WO2023192869A1
To make an immunotherapy that is effective for a larger group of cancer patients, Salmonella have been genetically engineered to deliver proteins from prior vaccines into the cytoplasm of tumor cells.
BOPI
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