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108
resultados
Última actualización
17/04/2026 [07:16:00]
Resultados 50 a 75 de 108
Resumen de: CN121517554A
本发明公开了鼠疫抗体Fm25及其应用，所述鼠疫抗体Fm25是一种靶向鼠疫菌F1蛋白的抗体，其重链可变区中的HCDR1‑3分别如SEQ ID NO:1‑3所示，轻链可变区中的LCDR1‑3分别如SEQ ID NO:5‑7所示，其对F1蛋白具有较高的结合活性和较好的结合特异性，能够用于鼠疫菌感染的检测和治疗中，对防控鼠疫具有重要意义。
Resumen de: EP4692334A1
An aim of the present invention is to provide a bacteriophage having a wide host range for bacteria of the genus Salmonella. The present invention is a bacteriophage with bacteriolytic activity against bacteria of the genus Salmonella, in which the bacteriophage has a genomic DNA sequence comprising a gene encoding a tail tip protein consisting of a specific amino acid sequence.
Resumen de: EP4692335A1
An aim of the present disclosure is: (i) to provide a novel bacteriophage having bacteriolytic activity against bacteria of the genus Salmonella, such as S. Enteritidis, or a bacteriolytic agent consisting of the same; (ii) to provide a bacteriophage having a wide host range for bacteria of the genus Salmonella, or a bacteriolytic agent consisting of the same; (iii) to provide a host-specific bacteriophage or an effective Salmonella bacteriolytic agent consisting of the same; or (iv) provide a bacteriophage capable of effectively controlling S. Typhimurium, and in particular, multidrug-resistant S. Typhimurium, or a bacteriolytic agent consisting of the same. The present disclosure provides: a bacteriophage having a specific genomic DNA sequence; a Salmonella bacteriolytic agent consisting of the bacteriophage; and a composition comprising the same.
Resumen de: CN121494931A
The invention belongs to the technical field of biology, and discloses an antibacterial peptide for regulating and controlling micro-ecology as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide or the salt thereof is disclosed for the first time, and the antibacterial peptide has a good antibacterial effect on common oral pathogenic bacteria (such as fusobacterium nucleatum and streptococcus gordoni), genital tract pathogenic bacteria (such as staphylococcus aureus, gardnebacterium and enterococcus faecalis) and other pathogenic bacteria (such as escherichia coli, salmonella enteritidis and streptococcus suis); and the compound shows slight cytotoxicity to mammalian cells only at a high concentration.
Resumen de: CN121496077A
The invention discloses a method for detecting salmonella typhimurium based on strand displacement reaction and CRISPR/Cas12a in combination with a colorimetric sensor and a dairy product detection method, and belongs to the technical field of food safety rapid detection. The invention provides a method for detecting salmonella typhimurium based on strand displacement reaction and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas12a combined with a colorimetric sensor in order to solve the problems of low sensitivity and inaccurate result of detection of salmonella typhimurium in dairy products by a traditional method in the prior art. According to the method, DNA-Ag/Pt NCs is used as a signal molecule to construct the aptamer colorimetric sensor for detecting salmonella typhimurium; the colorimetric sensor has relatively high sensitivity and specificity, and can quickly and conveniently realize on-site detection of salmonella typhimurium.
Resumen de: CN121495779A
The invention relates to the technical field of microbiology and molecular biology, in particular to sheep-derived bacillus velezensis AKH-1 and application thereof, the AKH-1 strain is preserved in China Center for Type Culture Collection on October 9, 2025, and the preservation number is CCTCC NO: M20252187. Experiments show that the strain has good gastrointestinal fluid and cholate tolerance, self-aggregation and hydrophobicity, can produce cellulase, amylase and protease, and has a remarkable inhibition effect on various pathogenic bacteria such as escherichia coli, salmonella and the like. Animal tests prove that the strain is safe and non-toxic, and can significantly promote the weight gain of mice and reduce the level of serum inflammatory factors. The AKH-1 strain disclosed by the invention has a wide application prospect in the aspect of preparing feed additives for inhibiting pathogenic bacteria, producing enzymes and promoting the growth of ruminants.
Resumen de: CN121495875A
The invention discloses an enterococcus faecalis bacteriophage vBEfaPFA1, a bacteriophage composition and application of the enterococcus faecalis bacteriophage vBEfaPFA1, the enterococcus faecalis bacteriophage vBEfaPFA1 has a specific lysis effect on enterococcus faecalis and also has a cross-species lysis effect on salmonella, the acid-base adaptability of the bacteriophage is high, and the enterococcus faecalis bacteriophage vBEfaPFA1 can be used as an active component to be prepared into the bacteriophage composition or a bacteriophage pharmaceutical preparation. The enterococcus faecalis bacteriophage and the bacteriophage composition are applied to preparation of drugs or bacteriostatic agents for preventing and treating enterococcus faecalis and salmonella infection, are safe to use, have no side effects, are easy to industrially produce, and are wide in lysis spectrum and wide in application range based on the cross-species lysis performance of the enterococcus faecalis bacteriophage and the bacteriophage composition.
Resumen de: CN121495796A
The invention relates to lactobacillus casei LC189 capable of inhibiting intestinal pathogenic bacteria and application of the lactobacillus casei LC189 capable of inhibiting the intestinal pathogenic bacteria, the lactobacillus casei capable of inhibiting the intestinal pathogenic bacteria is named as a lactobacillus casei LC189 strain, the preservation number is GDMCC No: 63092, and the preservation date is December 26, 2022. A novel lactobacillus casei strain with the effect of inhibiting enteropathogenic bacteria is separated from intestinal mucosa of a healthy sow and is preserved, the strain can inhibit the enteropathogenic bacteria such as escherichia coli, salmonella and staphylococcus aureus, and also can maintain the intestinal health of animals, and the specific expression is as follows: the diarrhea rate of piglets is reduced; the content of ammonia gas and methyl mercaptan in the excrement is reduced, and the pH value of the excrement returns to normal from a weak acid environment; beneficial bacteria are promoted to colonize in intestinal tracts, and the number of the beneficial bacteria is increased; the content of calprotectin in excrement is reduced, the inflammation level in the intestinal tract is reduced, and the intestinal tract health is promoted.
Resumen de: CN121494939A
The invention belongs to the technical field of biology, and discloses an antibacterial peptide with activity of inhibiting human pathogenic bacteria as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide or the salt thereof is disclosed for the first time, and the antibacterial peptide has a good antibacterial effect on common genital tract bacteria (such as staphylococcus aureus, gardnerella and candida albicans), oral pathogenic bacteria (such as fusobacterium nucleatum and streptococcus gordoni) and other pathogenic bacteria (such as escherichia coli, salmonella enteritidis and streptococcus suis); and the compound shows slight cytotoxicity to mammalian cells only at a high concentration.
Resumen de: CN121476591A
本发明具体涉及一种用于检测大肠杆菌的双模态生物传感器检测试剂盒及制备方法，属于食品安全检测技术领域。双模态生物传感器检测试剂盒由网状靶向磁珠和生物传感器检测试剂组成；生物传感器检测试剂为适配体修饰的铜金属掺杂碳点溶液，适配体为氨基化适配体。本发明的双模态传感器提供的双信号可以互相校准，避免单信号输出的偶然性误差，还可根据不同的场景选择优势检测模态；以网状PGA结构为中间体包覆四氧化三铁磁珠，高负载的网状结构为识别元件提供更多结合位点进一步增强了磁分离技术的捕获效率；增强磁分离技术驱动的双金属靶向改性碳点在检测大肠杆菌O157:H7时具有良好的检测性能，在食品基质中捕获低浓度目标菌的效率可达90%以上。
Resumen de: CN121472232A
本发明涉及生物技术领域，具体公开了一种阪崎克罗诺杆菌核酸适配体及其在制备生物传感器中的应用。本发明针对阪崎克罗诺杆菌MipA蛋白设计了DNA序列如SEQ ID No:1所示的核酸适配体，5’端氨基修饰。该适配体可用于构建荧光淬灭型生物传感器，包括荧光探针（枸橼酸二铵、硫脲、正硅酸甲酯及二氧化铈合成荧光纳米粒子，第一适配体羧基修饰）和淬灭探针（柠檬酸还原金纳米粒子，第二适配体巯基修饰，SEQ ID No:2）。与传统方法相比，筛选效率显著提升，检测时间<1h，抗干扰强，亲和常数13.28nM，适用于婴幼儿食品快速监测，经济成本降低至少40%。
Resumen de: CN121471909A
本发明属于食品安全检测技术领域，具体涉及一种叶酸‑邻苯二胺共掺杂碳量子点、大肠埃希氏菌O157:H7检测探针、检测试剂及应用。叶酸‑邻苯二胺共掺杂碳量子点由叶酸和邻苯二胺加热反应制得。基于本发明的叶酸‑邻苯二胺共掺杂碳量子点的检测探针或检测试剂对大肠埃希氏菌O157:H7进行检测，检测限低、特异性优异，实用性强。
Resumen de: CN121472086A
The invention provides a strain of high-temperature-resistant and inflammation-relieving Witzia ciliaris and an application thereof, the high-temperature-resistant and inflammation-relieving Witzia ciliaris is Witzia ciliaris CN985 and is preserved in the China Center for Type Culture Collection (CCTCC), the preservation date is April 7, 2024, and the preservation number is CCTCC NO: M 2024641. The invention further provides a preparation method of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain. The invention provides a brand new strain of Witzia ciliaris CN985, which is resistant to high temperature, has better acid resistance and bile resistance, and has no hemolysis risk when being applied to a human body. The Witzia coagulans CN985 has excellent antibacterial performance, and especially can significantly inhibit streptococcus pyogenes, salmonella enteritidis and/or group B streptococcus; besides, experimental results show that the Witzia ciliaris CN985 can relieve enteritis, improve the immunity of the organism and relieve pharyngitis, and especially when the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 are combined for use, the Witzia ciliaris CN985 and the phytobacterium plant
Resumen de: CN121472283A
The invention discloses bacillus subtilis for recombinant expression of a hermetia illucens HIAMP0438 gene and a construction method of the bacillus subtilis, and belongs to the technical field of gene engineering. The hermetia illucens recombinant protein used in the invention is obtained by expression of bacillus subtilis WB800N transferred into a pHT43-HIAMP0438 high-efficiency expression vector, and the pHT43-HIAMP0438 high-efficiency expression vector is obtained by a homologous recombination technology, so that high-level expression of the HIAMP0438 gene is realized, the HIAMP0438 gene can be efficiently secreted out of cells, the preparation process of the recombinant protein is greatly simplified, and the production cost is reduced. According to the present invention, the recombinant protein can significantly inhibit the growth of Escherichia coli, Salmonella and Listeria monocytogenes, and the recombinant protein can be used as the animal health product, and can be used for preventing and treating pig and chicken intestinal diarrhea caused by Escherichia coli and Salmonella and food-borne digestive tract diseases caused by Listeria monocytogenes.
Resumen de: CN121471323A
The invention provides a nano antibacterial peptide based on a leucine zipper and a preparation method and application thereof, and belongs to the technical field of biology, and the amino acid sequence of the nano antibacterial peptide is as shown in SEQ ID No.1. The antibacterial peptide disclosed by the invention has self-assembly capability, can be assembled to form a compact nanofiber net, has an antibacterial effect on gram-negative bacteria including escherichia coli, pseudomonas aeruginosa and salmonella typhimurium and gram-positive bacteria including staphylococcus aureus, staphylococcus epidermidis and enterococcus faecalis, and meanwhile, has relatively high biocompatibility, so that the antibacterial peptide can be used for preparing the antibacterial peptide. Moreover, the antibacterial peptide disclosed by the invention can stably exert an antibacterial effect under the conditions of serum, acid and alkali. In conclusion, the antibacterial peptide disclosed by the invention is an antibacterial peptide with relatively good antibacterial activity and biocompatibility.
Resumen de: CN121466192A
The invention discloses a traditional Chinese medicine composition for inhibiting salmonella choleraesuis as well as a preparation and application thereof, and belongs to the technical field of traditional Chinese medicine and network pharmacology. According to the invention, traditional Chinese medicines with a good antibacterial effect on S. Choletaesuis are screened, and the compound five-plum decoction with a good antibacterial effect on S. Choletaesuis is established. The five-plum decoction can be used for effectively regulating and controlling the steady state of intestinal flora, and reducing the oxidative damage and inflammatory damage of the S. Cholera to the intestinal tract and the liver by regulating and controlling the signal channels of TLR4/NF-kB/MyD88 and ZO-1/Claudin-1/Occludin. Through the multiple effects of resisting bacteria, resisting inflammation, protecting intestinal barriers and improving production performance, the five-plum decoction shows remarkable prevention and treatment effects on swine paratyphoid, and has huge value of being developed into a novel veterinary traditional Chinese medicine preparation and put into clinical application.
Resumen de: CN121471322A
The invention provides an antibacterial peptide ATMP23 mutant with improved antibacterial activity and application of the antibacterial peptide ATMP23 mutant in preparation of an antibacterial agent. The amino acid sequence of the antibacterial peptide ATMP23 provided by the invention is shown as SEQ ID NO: 1, amino acid mutation and screening are carried out on the basis of the amino acid sequence, and antibacterial peptide mutants A23-M4, A23-M5 and A23-M6 with significantly improved antibacterial activity are obtained. The antibacterial peptide ATMP23 mutant provided by the invention is small in molecular weight, convenient to artificially synthesize and low in cost, and has a good bactericidal effect on clostridium welchii, staphylococcus aureus, streptococcus, vibrio parahaemolyticus, vibrio alginolyticus, vibrio splendidus, salmonella, escherichia coli and the like; when being applied to livestock and aquatic feed, the feed conversion ratio of livestock and aquatic products can be remarkably reduced, the growth performance and immune function indexes of bred animals can be improved, and the feed additive can be widely applied to the industries of feed, food, medicine and the like.
Resumen de: WO2026027798A1
A yeast biomass composition is formed by culturing a strain of yeast in a substrate such as whey permeate to product a yeast broth, dewatering the broth to produce yeast biomass, and hydrolysing the yeast biomass. The yeast biomass composition finds utility as a feed additive for broiler chickens to reduce the adherence of pathogenic bacteria like Salmonella and E.coli to the gut wall of the chickens, thereby reducing intestinal stress and improving life daily weight gain in the chickens.
Resumen de: US20260035440A1
The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.
Resumen de: WO2026030756A2
The composition and methods of treatment disclosed or contemplated herein include compositions and methods of treatment for liver-related diseases. The overall treatment strategy would involve the identification of a target protein or receptor within the liver that is responsible for ongoing liver injury. The strain of orally administered Salmonella Typhimurium that colonizes the liver would be engineered to secrete a particular protein or nanobody that would stop and/or reverse the progressive hepatic disease
Resumen de: CN121454057A
本发明公开了一种多功能纳米材料荧光‑比色双模式食源性致病菌检测与杀灭方法及其系统。该方法利用具有纳米酶活性的金属有机框架材料（MIL‑53(Fe)）作为信号开关与发生器，联合荧光指示与光热杀菌单元的碳纳米点（CDs）共同构成了基础平台，利用适配体对纳米酶活性位点的掩蔽与目标菌触发下的竞争性释放为核心机制，激活比色与比率荧光双信号通道，实现自验证的高精度检测；并利用体系中的CDs作为光热元件，在检测后实现原位光热杀菌。通过更换适配体即可切换检测对象的“平台化”设计，展现了良好的通用性和应用前景，为食源性致病菌的检测与消除提供了灵敏、高效的新策略。
Resumen de: CN121450682A
The invention discloses a recombinant salmonella choleraesuis nuclease regulation vector as well as a construction method and application thereof. After oral administration, the recombinant salmonella choleraesuis nuclease regulatory vector rSC0140 enters host immune cells, c-di-AMP is released, a host STING pathway is activated, and a broad-spectrum antiviral effect can be achieved; the recombinant strain rSC0140 is proved to be capable of activating STING pathways in macrophages and mice, causing antiviral states of the macrophages and the mice and resisting challenge of various influenza viruses; the recombinant strain has broad-spectrum antiviral efficacy and is suitable for preventing and treating various virus diseases clinically.
Resumen de: CN121449738A
The invention discloses a monoclonal antibody combination for Brucella detection and application thereof, and belongs to the technical field of immunodetection. The monoclonal antibody combination disclosed by the invention comprises a monoclonal antibody 15F4 and a monoclonal antibody 32H9. On the basis of the monoclonal antibody combination, a double-antibody sandwich ELISA detection method with 15F4 as a capture antibody and enzyme-labeled 32H9 as a detection antibody is established, and key parameters such as coating concentration, closing conditions, incubation and color development time and the like are optimized. The method has high specificity on brucella, and does not cross with common cross-reactive bacteria such as escherichia coli O: 157, salmonella and the like; the sensitivity is high, and the detection limit can reach 1 * 10 < 5 > CFU/mL; the repeatability is good, and the intra-batch and inter-batch variation coefficients are both smaller than 10%. The invention provides a core reagent and a reliable means for early, rapid and accurate diagnosis of brucellosis, and is suitable for on-site screening of clinical samples and animal epidemic diseases.
Resumen de: KR20260015111A
본 개시는 편두통 진단을 위한 정보 제공 방법에 관한 것으로서, 보다 상세하게는 생물학적 시료에서 제멜라 헤몰리산스, 센티페다 페리오돈티, 카르디오박테리움 발바룸, 카토넬라 모르비 및 셀레노모나스 녹시아로 이루어진 군에서 선택된 적어도 하나의 박테리아의 상대적 풍부도를 측정하는 단계를 포함함으로써 환자의 통증 또는 거부감 없이 정확하고 신속한 편두통 진단을 가능하게 하는 방법에 관한 것이다.
Nº publicación: CN121427773A 30/01/2026
Solicitante:
GUANGXI UNIV FOR NATIONALITIES
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Resumen de: CN121427773A
The invention discloses lactobacillus johnsonii for preventing and treating pullorum disease salmonellosis and application of the lactobacillus johnsonii, and belongs to the field of microorganisms. According to the invention, a strain of Lactobacillus johnsonii LMZ8 is separated and screened, and the preservation number of the strain of Lactobacillus johnsonii LMZ8 is GDMCC No: 66614. The lactobacillus johnsonii LMZ8 is good in acid resistance and has certain tolerance to high-concentration cholate. Experimental results show that the lactobacillus johnsonii LMZ8 can effectively inhibit the growth of various pathogenic bacteria such as salmonella typhimurium and salmonella enteritidis, especially has a prominent inhibition effect on five strains of multi-drug-resistant salmonella pullorum with no same drug resistance spectrum, can effectively prevent and treat the pullorum disease caused by salmonella pullorum, and improves the growth performance of chicks. The lactobacillus johnsonii LMZ8 shows remarkable development potential in the aspects of preventing and controlling food-borne pathogenic bacteria and preventing and treating diseases such as pullorum disease, and has a wide development prospect.
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