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LastUpdate Última actualización 08/08/2025 [07:08:00]
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DEUTERATED HETEROCYCLIC KETONE COMPOUND AND USE THEREOF

NºPublicación:  US2025250254A1 07/08/2025
Solicitante: 
HINOVA PHARMACEUTICALS INC [CN]
HINOVA PHARMACEUTICALS INC
JP_2025510438_PA

Resumen de: US2025250254A1

A compound represented by formula (I) or an optical isomer, a pharmaceutically acceptable salt, a hydrate or a solvate thereof are provided. In formula (I), R1-R17 are each independently selected from hydrogen and deuterium, R18 and R19 are hydrogen, and R1-R19 are not simultaneously hydrogen. The deuterated compound and the salt, hydrate or solvate thereof have excellent metabolic stability and pharmacokinetic properties, and can be used in the manufacture of tubulin inhibitors, anti-cancer drugs, antiviral drugs, and drugs for the treatment of novel coronavirus pneumonia.

Vaccines against coronavirus and methods of use

NºPublicación:  AU2025205555A1 07/08/2025
Solicitante: 
INOVIO PHARMACEUTICALS INC
THE WISTAR INST OF ANATOMY AND BIOLOGY
Inovio Pharmaceuticals, Inc,
The Wistar Institute of Anatomy and Biology
US_2025121054_PA

Resumen de: AU2025205555A1

Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject. Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject. ul u l i s c l o s e d h e r e i n a r e n u c l e i c a c i d m o l e c u l e s e n c o d i n g a e v e r e c u t e e s p i r a t o r y y n d r o m e c o r o n a v i r u s ( - o - ) s p i k e a n t i g e n , - o - s p i k e a n t i g e n s , i m m u n o g e n i c c o m p o s i t i o n s , a n d v a c c i n e s a n d t h e i r u s e i n i n d u c i n g i m m u n e r e s p o n s e s a n d p r o t e c t i n g a g a i n s t o r t r e a t i n g a - o - i n f e c t i o n i n a s u b j e c t

BIFUNCTIONAL PEPTIDE WITH MUCOADHESIVE AND VIRUS BINDING PROPERTIES

NºPublicación:  US2025250312A1 07/08/2025
Solicitante: 
FREIE UNIV BERLIN [DE]
FORSCHUNGSVERBUND BERLIN E V [DE]
FREIE UNIVERSIT\u00C4T BERLIN,
FORSCHUNGSVERBUND BERLIN E.V
JP_2025514630_PA

Resumen de: US2025250312A1

A bifunctional peptide is provided, the bifunctional peptide comprising a virus binding moiety and a mucin binding moiety covalently bound to the virus binding moiety. The virus binding moiety is chosen from peptides binding to SARS-CoV-2, to influenza A, to influenza B, to rhinoviruses and other enteroviruses, to human parainfluenza virus, and/or to metapneuvirus. The mucin binding moiety is chosen from lectins such as trefoil factor 3.

STABLE CELL CLONES HARBORING REPLICATING SARS-COV-2 RNA

NºPublicación:  US2025250647A1 07/08/2025
Solicitante: 
THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN [US]
THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human
WO_2023081616_PA

Resumen de: US2025250647A1

Coronavirus genomes comprising non-native SARS-CoV-2 RNAs having genetically inactivated spike (S), envelope (E), and membrane (M) genes, and optionally a genetically inactivated nucleocapsid (NP) gene, are provided. Such coronavirus genomes further include a reporter gene and a marker gene, and substitutions within a non-structural protein 1 (Nsp1) gene (such as K164A and H165A). Also provided are cells containing the coronavirus genomes, for example, stable cell clones having the isolated non-native coronavirus genome autonomously replicating inside the cells. Also provided are methods of using such cells, for example, methods of identifying anti-viral compounds, such as quantitative high-throughput screening methods that can optionally be performed in a biosafety level 2 (BSL2) laboratory.

HEXAHYDRONAPHTHALEN-2-ONE DERIVATIVES FOR USE AGAINST A CORONAVIRUS INFECTION

NºPublicación:  US2025248965A1 07/08/2025
Solicitante: 
TAMOGATOTT KUTATOCSOPORTOK IRODAJA [HU]
EOETVOES LORAND TUDOMANYEGYETEM [HU]
NEMZETI NEPEGESZSEGUEGYI KOEZPONT [HU]
T\u00C1MOGATOTT KUTAT\u00D3CSOPORTOK IROD\u00C1JA,
E\u00D6TV\u00D6S LOR\u00C1ND TUDOM\u00C1NYEGYETEM,
NEMZETI N\u00C9PEG\u00C9SZS\u00C9G\u00DCGYI K\u00D6ZPONT
WO_2023017288_A1

Resumen de: US2025248965A1

Compounds for use against a viral infection The invention relates to hexahydronaphthalen-2-one derivatives, such as petasol, petasin and isopetasol, for use in the prevention or the treatment of viral infections. In particular compounds extracted from Darksidea spp. are provided for use in the treatment of SARS-CoV-2 infection.

THERAPEUTIC AND VACCINE CANDIDATES AGAINST SARS-CoV-2

NºPublicación:  US2025249088A1 07/08/2025
Solicitante: 
GENEONE LIFE SCIENCE INC [KR]
GENEONE LIFE SCIENCE, INC
WO_2023073672_PA

Resumen de: US2025249088A1

Provided herein is an immunogenic composition comprising a synthetic antigen to COVID spike proteins, particularly the chimeric intermediate structure C-A Complex. Also disclosed herein is a method of preventing and/or treating a COVID infection in a subject in need thereof, by administering the immunogenic composition to the subject.

RECOMBINANT PLASMID, IMMUNOGENIC COMPOSITION, KIT AND USES THEREOF

NºPublicación:  US2025249089A1 07/08/2025
Solicitante: 
FUND OSWALDO CRUZ FIOCRUZ [BR]
FUNDA\u00C7\u00C3O OSWALDO CRUZ (FIOCRUZ)

Resumen de: US2025249089A1

Recombinant plasmids and immunogenic DNA compositions including a recombinant plasmid which carries the gene sequence encoding the Spike protein or the gene sequence encoding the NP protein, with the capacity to prevent high viral loads and moderate and severe clinical forms of the disease by stimulating the immune system, both against the ancestral strain of SARS-CoV-2 and influenza strains against different variants of concern that are currently circulating are disclosed. A bivalent recombinant plasmid and a immunogenic composition including the bivalent recombinant plasmid which carries the gene sequence encoding the NP and Spike protein, with the capacity to prevent high viral loads and moderate and severe clinical forms of the disease by stimulating the immune system, both against the influenza strain and SARS-COV-2 strain against different variants of concern that are currently circulating are disclosed.

MODIFIED ACE2 PROTEINS WITH IMPROVED ACTIVITY AGAINST SARS-COV-2

NºPublicación:  EP4594483A1 06/08/2025
Solicitante: 
DEUTSCHES KREBSFORSCH [DE]
UNIV TUEBINGEN MEDIZINISCHE FAKULTAET [DE]
Deutsches Krebsforschungszentrum,
Eberhard Karls Universit\u00E4t T\u00FCbingen, Medizinische Fakult\u00E4t
WO_2024068777_A1

Resumen de: WO2024068777A1

The present invention relates to therapeutic proteins and medical uses thereof. The present invention relates to modified ACE2 protein having increased binding affinity for the SARS- CoV-2 spike protein compared to wildtype ACE2 protein, wherein said modified ACE2 protein is lacking enzymatic activity and is fused to (i) a modified Fc domain of human immunoglobulin, wherein the Fc domain has either enhanced immunostimulating activity (Fc+) or attenuated immunostimulating activity (Fc-) or (ii) a protein that specifically binds to T cells or further enhances immunostimulating activity. The invention also relates to a polynucleotide encoding the modified ACE2 protein of the present invention, a vector or expression construct comprising the polynucleotide, a host cell comprising the polynucleotide or the vector or expression construct, and a non-human transgenic organism comprising the polynucleotide or the vector or expression construct. Moreover, the present invention relates also to a method for the manufacture of a modified ACE protein according to the present invention and to a medicament comprising the modified ACE2 protein, the polynucleotide or the vector or expression construct of the invention. Furthermore, the invention relates to medical uses of the modified ACE2 protein, the polynucleotide or the vector or expression construct in treating and/or preventing a disease or disorder associated with SARS-CoV-2 infection. Finally, the invention provides a kit comprising th

VIRUS-LIKE PARTICLES DISPLAYING SARS-COV-2 ANTIGENS AS BOOSTER VACCINES AND USES THEREOF

NºPublicación:  EP4593874A2 06/08/2025
Solicitante: 
BAVARIAN NORDIC AS [DK]
Bavarian Nordic A/S
WO_2024068265_A2

Resumen de: WO2024068265A2

The present invention relates to the use of vaccines comprising virus-like particles displaying at least one SARS-CoV-2 antigen, such as the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, as vaccine boosters. Antigens are displayed on virus-like particles (VLPs) and produce an immune response in vaccinated subjects. The invention also relates to methods of treatment using the recombinant VLPs as boosters to treat and/or prevent infection with SARS-CoV-2, and methods of preparation thereof.

ENGINEERED PHAGE AND KIT FOR CAPTURING SARS-COV-2 AND METHOD FOR DETECTING SARS-COV-2 VIRUS BY MEANS OF SAID PHAGE OR KIT

NºPublicación:  EP4594340A1 06/08/2025
Solicitante: 
UNIV BOLOGNA ALMA MATER STUDIORUM [IT]
UNIV DEGLI STUDI DI MESSINA [IT]
Alma Mater Studiorum - Universit\u00E0 di Bologna,
Universit\u00E0 Degli Studi Di Messina
CN_120051481_PA

Resumen de: CN120051481A

The invention discloses a phage for specifically capturing SARS-CoV-2 virus, the phage is an engineered M13 phage, so that an FGKGGYEKTWKLGD sequence peptide or an EFTSKAR sequence peptide is displayed on a P8 protein of a shell of the phage, and the peptide has specific affinity to a spike S1 protein of the SARS-CoV-2 virus.

STABILIZED VACCINES

NºPublicación:  MX2025005412A 01/08/2025
Solicitante: 
SEQIRUS INC [US]
SEQIRUS INC
MX_2025005412_A

Resumen de: MX2025005412A

The present disclosure relates to a fusion protein comprising an ectodomain of a viral fusion protein linked to one or more heptad repeat(s) (HR(s)) from a SARS-COV-2 spike (S) protein or a respiratory syncytial virus (RSV) F protein, and the uses thereof. The viral fusion proteins are suitable for use as vaccines.

DIAGNOSTIC TESTING APPARATUS AND SYSTEM

NºPublicación:  MX2025002237A 01/08/2025
Solicitante: 
RAPID VIRAL DETECTION SYSTEMS LLC [US]
RAPID VIRAL DETECTION SYSTEMS LLC
MX_2025002237_A

Resumen de: MX2025002237A

A method and an apparatus utilizing targeted ion mobility spectrometry for the detection of the SARS-CoV-2 virus and its variants, by measuring the quantity of free polyamines including putrescine, spermidine, and spermine in a sublingual saliva sample. Other embodiments are capable of providing instant, cost effective, POC testing and test results for other viral and bacterial infections including influenza, acute and chronic respiratory conditions, certain forms of inflammation, and the detection of certain abnormal cells in human subjects.

APPLICATION OF SHENLING BAIZHU IN PREPARATION OF DRUG FOR TREATING PSYCHONEUROLOGICAL SYMPTOMS OF RECOVERED COVID-19 PATIENTS

NºPublicación:  MX2025007248A 01/08/2025
Solicitante: 
BEIJING REDSUN PHARMACEUTICAL CO LTD [CN]
BEIJING REDSUN PHARMACEUTICAL CO., LTD
MX_2025007248_A

Resumen de: MX2025007248A

An application of shenling baizhu in the preparation of a drug for treating psychoneurological symptoms of recovered COVID-19 patients.

METHODS OF TREATING INFLAMMATORY DISEASES BY BLOCKING GALECTIN-3

NºPublicación:  US2025243282A1 31/07/2025
Solicitante: 
TRUEBINDING INC [US]
TrueBinding, Inc
MX_2022014786_A

Resumen de: US2025243282A1

Disclosed herein are methods, antibodies, and compositions for disrupting an interaction between Galectin-3 (Gal3) and viral proteins, such as proteins of the SARS-CoV-2 virus or other coronaviruses, or viral-associated host proteins. Further disclosed herein are methods, medicaments, and compositions for the treatment of a disease or a disorder in a subject, such as the treatment of a viral infection, or treatment of a fibrosis, such as lung fibrosis, that develop as a sequela of a viral infection, or cytokine release syndrome. Further disclosed herein are methods, medicaments, and compositions for the treatment of an inflammatory disease or disorder, such as inflammation of the lungs or systemic lupus erythematosus, which may be associated with neutrophil activity, in a subject. Also disclosed herein are pharmaceutical antibody formulations for the treatment of a disease, such as a coronavirus infection.

CORONAVIRUS VACCINE

NºPublicación:  US2025242059A1 31/07/2025
Solicitante: 
BIONTECH SE [DE]
BioNTech SE
US_2025242059_A1

Resumen de: US2025242059A1

This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.

NLRP3 INFLAMMASOME INHIBITORS AND COMPOSITIONS AND USES THEREOF

NºPublicación:  US2025243172A1 31/07/2025
Solicitante: 
VIRGINIA COMMONWEALTH UNIV [US]
VIRGINIA COMMONWEALTH UNIVERSITY
WO_2023204967_A1

Resumen de: US2025243172A1

NLRP3 selective inhibitors (NSIs) as anti-inflammatory agents are provided, as are methods of using NSIs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, traumatic brain injury, acute myocardial infarction, heart failure, arthritis, diabetes, gout, COVID-19, and autoinflammatory diseases.

COMPOSITION FOR PREVENTING OR TREATING CHEMOSENSORY DISORDER

NºPublicación:  AU2024251861A1 31/07/2025
Solicitante: 
NAGASAKI UNIV
KIRIN HOLDINGS KK
NAGASAKI UNIVERSITY,
KIRIN HOLDINGS KABUSHIKI KAISHA
AU_2024251861_PA

Resumen de: AU2024251861A1

The purpose of the present invention is to provide a composition for preventing or treating a chemosensory disorder. The present invention provides a composition for preventing or treating a chemosensory disorder, the composition including lactic acid bacteria. The chemosensory disorder may be a chemosensory disorder that occurs after SARS-CoV-2 virus infection. The present invention is advantageous in that lactic acid bacteria can be used as a functional ingredient that imparts a preventive or therapeutic effect for a chemosensory disorder, and in that pharmaceuticals or foodstuffs that are safe for mammals, including humans, can be provided.

ANTI-SARS-COV-2 ANTIBODIES AND USES THEREOF II

NºPublicación:  US2025244325A1 31/07/2025
Solicitante: 
SEQIRUS PTY LTD [AU]
Seqirus Pty Ltd
JP_2024536381_A

Resumen de: US2025244325A1

The present disclosure relates to anti-SARS-COV-2 antibodies and uses thereof in detecting intact multimeric and/or intact trimeric severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike protein in a sample.

USE OF SHENLING BAIZHU IN PREPARING MEDICAMENT FOR TREATING POST-HEALING SEQUELAE OF NOVEL CORONAVIRUS INFECTED PERSON

NºPublicación:  AU2023412582A1 31/07/2025
Solicitante: 
BEIJING HANDIAN PHARMACEUTICAL CO LTD
BEIJING HANDIAN PHARMACEUTICAL CO., LTD
AU_2023412582_A1

Resumen de: AU2023412582A1

Provided is use of Shenling Baizhu in preparing a medicament for treating post-healing sequelae of a novel coronavirus infected person. The sequela is selected from at least one of short of breath, fatigue and weakness, inappetence, and diarrhea. The Shenling Baizhu is prepared from the following raw materials in parts by weight: 400 parts of ginseng, 400 parts of poria cocos, 400 parts of Rhizoma Atractylodis macrocephalae stir-fried with bran, 400 parts of Chinese yam, 300 parts of fried white hyacinth beans, 200 parts of lotus seeds, 200 parts of coix seeds stir-fried with bran, 200 parts of Fructus amomi, 200 parts of Platycodon grandiflorum, and 400 parts of liquorice.

METHODS OF ANALYZING SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 2 (STNFR2) AND USES THEREOF

NºPublicación:  US2025244338A1 31/07/2025
Solicitante: 
AION HEALTHSPAN INC [US]
UNIV OF MIAMI [US]
AION HEALTHSPAN, INC,
University of Miami
CN_120380135_PA

Resumen de: US2025244338A1

The present disclosure relates to methods of testing immunomodulatory activity of cells, including, for example, mesenchymal stem cells and uses of said cells that are determined as having immunomodulatory activity for treating COVID-19 related acute respiratory distress syndrome (ARDS). Disclosed herein are in vitro methods of evaluating mesenchymal stem cells for their effective immunomodulatory effects in vivo.

BLOOD BIOMARKERS IN LONG-COVID-19

NºPublicación:  US2025244326A1 31/07/2025
Solicitante: 
LONDON HEALTH SCIENCES CENTRE RES INC [CA]
LONDON HEALTH SCIENCES CENTRE RESEARCH INC
WO_2023147669_PA

Resumen de: US2025244326A1

A method of diagnosing long-COVID in a subject, the method comprising: (a) measuring the level of one or more biomarkers in a test sample obtained from the subject, and (b) comparing the level of the one or more biomarkers in the test sample with a healthy control and/or an acute COVID-19 reference level value of said one or more biomarkers, wherein an increase in the level of the one or more biomarkers in the test sample relative to the healthy control and/or acute COVID-19 reference level value of said one or more biomarkers is indicative of long-COVID diagnosis, and wherein the one or more biomarkers are selected from Table 5. In one embodiment, the one or more biomarkers include ANG-1, P-Sel and MMP-1. A method of treating long-COVID comprising administering to a subject one or more of the biomarkers are selected from Table 5.

PEPTIDE FOR PREVENTION OR TREATMENT OF COVID-19

NºPublicación:  US2025241978A1 31/07/2025
Solicitante: 
APEPTICO FORSCHUNG UND ENTW GMBH [AT]
APEPTICO FORSCHUNG UND ENTWICKLUNG GMBH
US_2025241978_PA

Resumen de: US2025241978A1

A peptide for prevention and treatment of COVID-19 in a patient, wherein the peptide consists of 7-17 amino acids and includes the hexamer TX1EX2X3E, wherein X1, X2 and X3 can be any natural or non-natural amino acid, and wherein the peptide does not exhibit TNF-receptor-binding activity. Suitable peptides include solnatide (cyclo-CGQRETPEGAEAKPWYC).

VIRUS-LIKE PARTICLE STABLY EXPRESSED BY ANIMAL CELLS AS VACCINE ANTIGEN AGAINST COVID-19 AND INFLUENZA VIRUS

NºPublicación:  US2025242013A1 31/07/2025
Solicitante: 
ACAD SINICA [TW]
ACADEMIA SINICA
US_2025242013_PA

Resumen de: US2025242013A1

The disclosure provides an animal cell stably expressing a virus-like particle (VLP). The disclosure also provides a method for manufacturing a virus-like particle, a virus-like particle, a vaccine composition, a method for preventing viral infection, and a method for producing antibodies.

Method for manufacturing SARS-CoV-2 autologous vaccine using recombinant SARS-CoV-2 lentiviral vector

NºPublicación:  KR20250115147A 30/07/2025
Solicitante: 
국립경국대학교산학협력단

Resumen de: KR20250115147A

본 발명은 재조합 SARS-CoV-2 렌티바이러스 벡터를 이용한 SARS-CoV-2 자가면역 백신의 제조방법에 관한 것으로, 구체적으로 본 발명은 SARS-CoV-2 바이러스의 항원 단백질을 암호화하는 폴리뉴클레오티드를 포함하는 수지상 세포에서 면역원성 항원 단백질의 발현을 유도하기 위한 재조합 렌티바이러스 벡터, 상기 본 발명의 재조합 렌티바이러스 벡터를 수지상 세포에 형질도입하는 단계를 포함하는, 수지상 세포 기반의 SARS-CoV-2 바이러스 감염증 예방용 백신 조성물의 제조방법 및 상기 방법으로 제조된 SARS-CoV-2 바이러스 감염증 예방용 백신 조성물에 관한 것이다.

PROTECTIVE APPARATUSES FOR MINIMIZING RISK OF TRANSMISSION OF INFECTION AND ASSOCIATED SYSTEMS

Nº publicación: EP4591823A2 30/07/2025

Solicitante:

JAMES L ORRINGTON II D D S P C [US]
James L. Orrington, II D.D.S., P.C

EP_4591823_A2

Resumen de: EP4591823A2

Disclosed herein are protective apparatuses, and associated systems, for minimizing the risk of transmission of SARS-CoV-2 and/or other infectious diseases between individuals in close proximity to one another including, for example, transmission through droplets projecting from the mouth or nasal region of an infected individual. Said apparatuses may comprise a substantially transparent shield component and a handle component comprising a connecting aspect. The protective apparatuses may comprise light emitting diodes and associated control means. The protective apparatuses of the present disclosure may further comprise a camera communicatively connected to a display screen.

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