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LastUpdate Última actualización 17/04/2026 [07:09:00]
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Solicitudes publicadas en los últimos 60 días/Published applications in the last 60 days
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Immuno-therapeutic chemical compositions and uses thereof

NºPublicación:  US12569492B1 10/03/2026
Solicitante: 
MOHENO PHILLIP [US]
Moheno Phillip
US_12569492_B1

Resumen de: US12569492B1

Disclosed herein are methods for the treatment of cancer and inflammatory-based diseases and disorders, such as coronavirus colds and as a therapy against COVID-19. ImmunoFolate has been shown to reduce the incidents of colds and flus. In one embodiment is a method of treating cancer comprising administration of ImmunoFolate. In another embodiment is a method of treatment inflammatory-based disease and disorders comprising administration of ImmunoFolate.

Combination Vaccine For Prevention Of Influenza And Coronavirus Infections

NºPublicación:  US20260061046A1 05/03/2026
Solicitante: 
NATIONAL UNIV CORPORATION HOKKAIDO UNIV [JP]
KM BIOLOGICS CO LTD [JP]
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY,
KM Biologics Co., Ltd
US_20260061046_PA

Resumen de: US20260061046A1

Disclosed is a combination vaccine for prevention of influenza and novel coronavirus infections. The combination vaccine for vaccination against influenza and novel corona viruses was obtained by inactivating all influenza virus particles and all novel coronavirus particles respectively, thereby inducing the antibodies to each virus without affecting each vaccine effect, so that the defensive effects were obtained against the attacks of each virus. In addition, the combination vaccine with this combination exhibited favorable neutralizing antibody induction and defensive effects to the attacks of these viruses even without addition of an adjuvant.

SARS-COV-2 IMMUNOGENIC COMPOSITIONS

NºPublicación:  WO2026047603A1 05/03/2026
Solicitante: 
BIONTECH SE [DE]
PFIZER INC [US]
BIONTECH SE,
PFIZER INC
WO_2026047603_PA

Resumen de: WO2026047603A1

Disclosed herein are compositions comprising protein antigens and RNA encoding the same (eg., compositions comprising protein antigens and RNA encoding antigens) that can be used to induce an immune response against SARS-CoV-2. Also disclosed herein are immunogenic compositions and medical preparations comprising the same, and methods of making and using the same. In some embodiments, the technologies provided herein can be used to address and/or overcome immune imprinting in SARS-CoV-2.

SARS-COV-2 VACCINES AND THERAPEUTICS

NºPublicación:  WO2026047716A1 05/03/2026
Solicitante: 
POPVAX PRIVATE LTD [IN]
POPVAX PRIVATE LIMITED
WO_2026047716_PA

Resumen de: WO2026047716A1

The present disclosure relates generally to receptor binding domain of SARS-CoV- 2 and nucleic acids encoding the receptor binding domain, wherein the receptor binding domain comprises one or more mutations at amino acid positions selected from the group comprising R28T, K38V or T, K126T, F138L, A157V, V165del, E166A or K or P, Q175E, S176P, A202G, or a combination thereof compared to SEQ ID NO: 1. Such a receptor binding domain can be included as one of the components or constituents of polypeptide or multisubunit peptide disclosed herein, including the nucleic acids encoding them.

Novel coronavirus recombinant subunit antigen, preparation method thereof and application of novel coronavirus recombinant subunit antigen in vaccine

NºPublicación:  CN121574211A 27/02/2026
Solicitante: 
BIG HEALTH RES INSTITUTE OF HEFEI INTEGRATED SCIENCES CENTER
\u5408\u80A5\u7EFC\u5408\u6027\u56FD\u5BB6\u79D1\u5B66\u4E2D\u5FC3\u5927\u5065\u5EB7\u7814\u7A76\u9662
CN_121574211_PA

Resumen de: CN121574211A

The invention provides a novel coronavirus recombinant subunit antigen as well as a preparation method and application thereof in vaccines. Specifically, the invention provides a novel coronavirus recombinant subunit antigen, and a corresponding recombinant protein, coding polynucleotide, a vector, a host cell, an immune antigen, a pharmaceutical composition and the like thereof, and also provides a preparation method and application. The novel coronavirus recombinant subunit antigen and the recombinant protein thereof provided by the invention have high conservative property aiming at the coronavirus and a new crown mutant strain, contain rich effective T cell epitopes, and can stimulate an organism to generate an antigen-specific antibody and cellular immune response. The novel coronavirus recombinant subunit antigen and the recombinant protein thereof can utilize an eukaryotic expression system as an expression vector, have the advantages of high yield, high protein purity, similar state to physiological state and the like, and are suitable for large-scale preparation and development of broad-spectrum new crown vaccines.

COMPOSITIONS CONTAINING VERTEPORFIN, RIBAVIRIN, GEMCITABINE, OR COMBINATIONS THEREOF AND METHODS OF USE FOR TREATING COVID-19, CANCER, OR NON CANCER DISEASES

NºPublicación:  US20260053779A1 26/02/2026
Solicitante: 
MCLEAY MATTHEW T [US]
MCLEAY MATTHEW T
US_20260053779_A1

Resumen de: US20260053779A1

Disclosed are pharmaceutical formulations and methods using Verteporfin, Ribavirin, and/or Gemcitabine for use in the treatment of diseases by various routes of administration including inhalation, intratumoral, topical and/or systemic injection administration. This invention relates more specifically to the use of Verteporfin, Ribavirin, Gemcitabine, and/or combinations thereof as an inhaled dry powder treatment for COVID-19 and/or other lung infections, cancer and other non-cancer applications, which may be followed by other treatment regimens including radiation therapy, photodynamic therapy, and/or sonodynamic therapy. These pharmaceutical compositions containing one or more of Verteporfin, Ribavirin, and Gemcitabine may be included in pharmaceutical kits containing the compositions, and to methods for the treatment of cancer and non-cancer diseases with the active agents of the pharmaceutical compositions. The administering of Verteporfin alone or in combination with Ribavirin and Gemcitabine may be followed or co-administered with photodynamic and/or sonodynamic therapy (PDT/SDT).

HYDROGEL COMPRISING GLYCEROL AND A CARBOMER FOR TREATING THE RESPIRATORY SYMPTOMS OF COVID-19 DISEASE VIA THE NASAL ROUTE

NºPublicación:  US20260053741A1 26/02/2026
Solicitante: 
COSMOSOFT [FR]
COSMOSOFT
US_20260053741_A1

Resumen de: US20260053741A1

The invention relates to a product for treating viral diseases, such as COVID-19, via the nasal route. The product comprises a hydrogel based on water, glycerol and a carbomer.

METHODS OF PROPHYLAXIS OF CORONAVIRUS INFECTION AND TREATMENT OF CORONAVIRUSES

NºPublicación:  US20260053745A1 26/02/2026
Solicitante: 
CUREMARK LLC [US]
Curemark, LLC
US_20260053745_PA

Resumen de: US20260053745A1

Methods for prophylaxis, treatment, and reduction of infection, re-infection, and transmission rates of Coronaviruses and more particularly Coronavirus Disease 2019 (COVID-19) resulting from a SARS-CoV-2 viral infection with the use of a pharmaceutical preparation comprising one or more coated or uncoated digestive enzymes, such as pancreatic enzymes and porcine pancreatic enzymes are described herein.

HALOPHTHALIMIDE COMPOUNDS AND METHODS OF USE AGAINST TBI, INFLAMMATORY DISORDER, AUTOIMMUNE DISORDER, NEURODEGENERATIVE DISEASE OR VIRAL INFECTION

NºPublicación:  US20260055061A1 26/02/2026
Solicitante: 
THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES [US]
AEVISBIO INC [US]
The United States of America, as represented by the Secretary, Department of Health & Human Services,
AevisBio, Inc
US_20260055061_PA

Resumen de: US20260055061A1

Halophthalimides are disclosed. The halophthalimides may inhibit TNF-α activity, TNF-α synthesis, inflammation, inducible nitric oxide synthase, SARS-CoV-2 virus, or any combination thereof. The halophthalimides may be administered to a subject with a traumatic brain injury, an inflammatory disorder, an autoimmune disorder, a neurodegenerative disease, a viral infection, or any combination thereof. The disclosed halophthalimides have a structure according to Formula I, or a stereoisomer or pharmaceutically acceptable salt, solvate, or hydrate thereof,where R5 isAt least one of R2-R4 or Re is halo.

MACHINE-LEARNING-BASED METHOD FOR SCREENING CROSS-DIFFERENTIALLY EXPRESSED GENES BETWEEN LUNG CANCER AND COVID-19 INFECTION AND CORRESPONDINGLY SCREENING PROGNOSTIC GENES OF LUNG CANCER

NºPublicación:  WO2026040166A1 26/02/2026
Solicitante: 
DALIAN MINZU UNIV [CN]
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WO_2026040166_PA

Resumen de: WO2026040166A1

The present invention belongs to the technical field of bioinformatics, and relates to a machine-learning-based method for screening cross-differentially expressed genes between lung cancer and COVID-19 infection and correspondingly screening prognostic genes of lung cancer. The method comprises: acquiring cross-differentially expressed genes between lung cancer and COVID-19; screening the cross-differentially expressed genes between lung cancer and COVID-19 infection; using Cox regression and LASSO regression to correspondingly screen prognostic genes of lung cancer; and using a K-M survival analysis method, GO and KEGG enrichment analysis methods and a protein-protein interaction analysis method to analyze screened-out prognostic genes of lung cancer. The method provided herein can process data, and can also identify intricate patterns in the data, and has relatively high sensitivity and specificity, thereby improving the efficiency and accuracy of screening. The technique can be extended to the research of other diseases, and features universality.

T CELL BROAD BETACORONAVIRUS VACCINE

NºPublicación:  AU2024333842A1 26/02/2026
Solicitante: 
NEC ONCOIMMUNITY AS [NO]
NEC ONCOIMMUNITY AS
AU_2024333842_PA

Resumen de: AU2024333842A1

The present invention relates to polypeptides, polynucleotides, compositions, microorganisms, vectors and vaccine compositions optimised for the treatment or prophylaxis of a disease or infection caused by Betacoronaviruses, including but not limited to: Embecovirus, Hibecovirus, Merbecovirus, Nobecovirus, Sarbecovirus, MERS-CoV, SARS-CoV-1 and SARS-CoV-2. In particular, the invention provides a vaccine composition comprising a polypeptide, wherein the polypeptide comprises one or more epitope sequences, wherein the one or more epitope sequences have the amino acid sequences of any one or more of the sequences of Table 1, or a variant thereof having at least 70% sequence identity thereto, and wherein the polypeptide sequence is no more than 1400 amino acids in length.

COMPOUNDS WITH ACTIVITY AGAINST SARS-COV-2

NºPublicación:  EP4698279A1 25/02/2026
Solicitante: 
NATIONAL HELLENIC RES FOUNDATION [GR]
CENTRE FOR RESEARCH AND TECH HELLAS [GR]
DEMOCRITUS UNIV OF THRACE [GR]
NATIONAL AND KAPODISTRIAN UNIV OF ATHENS [GR]
DARAS PETROS [GR]
AXENOPOULOS APOSTOLOS [GR]
MYLONAS STYLIANOS [GR]
KATSAMAKAS SOTIRIOS [GR]
STAMATOPOULOS KONSTANTINOS [GR]
PETRAKIS SPYRIDON [GR]
KARAKASILIOTIS IOANNIS [GR]
National Hellenic Research Foundation,
Centre for Research and Technology Hellas,
Democritus University Of Thrace,
National and Kapodistrian University of Athens,
Daras, Petros,
Axenopoulos, Apostolos,
Mylonas, Stylianos,
Katsamakas, Sotirios,
Stamatopoulos, Konstantinos,
Petrakis, Spyridon,
Karakasiliotis, Ioannis
WO_2024218171_A1

Resumen de: WO2024218171A1

Compounds of Formula (I), pharmaceutical compositions containing them and their use in the treatment of a SARS-CoV-2 infection.

Production method

NºPublicación:  CN121568702A 24/02/2026
Solicitante: 
AG IP PTY LTD
AG IP\u79C1\u4EBA\u6709\u9650\u516C\u53F8
CN_121568702_A

Resumen de: CN121568702A

The present invention relates, inter alia, to a process for the preparation of garlic oil, to garlic oil produced using this process, to pharmaceutical compositions comprising this garlic oil and to the use of this garlic oil in the treatment of viral infections such as SARS-COV-2 and influenza A. A method of making a garlic oil comprises the steps of: a) processing a portion of a garlic plant to increase its surface area; b) aging the portion of the garlic plant for at least 18 months to provide aged garlic, the step not comprising the addition of ethanol; and c) separating garlic oil from the aged garlic. Step c) may be performed using rotating cone distillation or supercritical fluid extraction at a temperature of less than 110 DEG C or such that the pressure (atmospheric pressure) divided by the temperature (Kelvin temperature) is equal to or less than about 0.0026.

Novel coronavirus infection restrictive factor and application thereof

NºPublicación:  CN121554561A 24/02/2026
Solicitante: 
UNIV ZHEJIANG
\u6D59\u6C5F\u5927\u5B66
CN_121554561_PA

Resumen de: CN121554561A

The invention relates to the technical field of biology, and discloses a novel coronavirus infection restrictive factor and application thereof. The invention also discloses a method for inhibiting the replication of the coronavirus, which inhibits the replication of the coronavirus by up-regulating the expression level of the VHL protein or the N-terminal active fragment of the VHL protein in the host cell. The NCBI (National Center of Biotechnology Information) login number of the VHL protein is NP000542.1, and the amino acid sequence of the active fragment at the N end of the VHL protein is MPRRAENWDEAEVGAEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR. The amino acid sequence of the active fragment at the N end of the VHL protein is shown in the description. According to the novel coronavirus infection restrictive factor and the application thereof, the replication of coronavirus can be inhibited by up-regulating the expression level of the VHL protein or the N-terminal active fragment of the VHL protein in a host cell, so that the novel coronavirus infection restrictive factor is used for preparing an antiviral pharmaceutical preparation.

Fluorescence-quenching labeled double-stranded universal probe and mediated amplification method and application thereof

NºPublicación:  CN121555663A 24/02/2026
Solicitante: 
UNIV FUJIAN MEDICAL
\u798F\u5EFA\u533B\u79D1\u5927\u5B66
CN_121555663_PA

Resumen de: CN121555663A

The invention belongs to the technical field of biological detection, and particularly relates to a fluorescence-quenching labeled double-chain universal probe and a mediated amplification method and application thereof. The nucleic acid detection system comprises a fluorescence-quenching labeled double-stranded universal probe, the double-stranded universal probe is composed of two complementary oligonucleotide chains, and the nucleotide sequences of the double-stranded universal probe are shown as SEQ ID NO: 1-4. According to the pathogen nucleic acid detection method based on the universal probe and the target specific anchoring primer, a real-time quantitative PCR or isothermal amplification technology and a fluorescence resonance energy transfer mechanism are integrated, and synchronous and accurate detection of mycoplasma pneumoniae, streptococcus pneumoniae, haemophilus influenzae, influenza A virus, influenza B virus, novel coronavirus and the like is achieved. The method does not need pathogen culture, solves the problems of insufficient specificity, high cost, tedious operation and the like of a traditional detection technology, and can be applied to rapid diagnosis of clinical pathogen infection, reasonable use guidance of antibiotics and epidemiological monitoring.

IMMUNOASSAY FOR SARS-CoV-2 ANTIBODIES

NºPublicación:  US20260049994A1 19/02/2026
Solicitante: 
PICTOR LTD [NZ]
Pictor Limited
US_20260049994_A1

Resumen de: US20260049994A1

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Antibodies produced from an immune response against SARS-CoV-2 infection are used to analyze prior exposure to the virus. The present invention provides methods for detecting antibodies in response to SARS-CoV-2 infection in a single multiplex immunoassay.

ANTIBODIES AGAINST COVID-19 AND OTHER HUMAN CORONAVIRUSES

NºPublicación:  AU2024298416A1 19/02/2026
Solicitante: 
FOND BIOTECNOPOLO DI SIENA
FONDAZIONE BIOTECNOPOLO DI SIENA
AU_2024298416_A1

Resumen de: AU2024298416A1

The present invention relates to monoclonal antibodies or antigen-binding portion thereof that have a potent neutralizing activity against Coronavirus, in particular against at least one virus selected from SARS-CoV-2, SARS-CoV-1 and variants thereof. The invention relates also to the use of such monoclonal antibodies or antigen-binding portion thereof in therapy, prophylaxis, and diagnosis of Coronavirus, in particular SARS-CoV-2 and/or SARS-CoV-1 dependent diseases.

VALACYCLOVIR AND CELECOXIB FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND COVID-19

NºPublicación:  US20260048058A1 19/02/2026
Solicitante: 
DOGWOOD THEPAPEUTICS INC [US]
Dogwood Thepapeutics, Inc
US_20260048058_A1

Resumen de: US20260048058A1

The present disclosure relates to methods of treating Alzheimer's disease, diseases and/or conditions associated with Covid-19 infection, including long COVID, a post-acute infection syndrome, or symptoms of orthostatic intolerance comprising administration of a therapeutically-effective combination of a COX-2 inhibitor and an antiviral compound.

ENHANCING THE SOLUBILITY OF SARS-COV-2 INHIBITORS TO INCREASE CLINICAL POTENTIAL

NºPublicación:  WO2026039749A1 19/02/2026
Solicitante: 
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK [US]
WISCONSIN ALUMNI RES FOUNDATION WARF [US]
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK,
WISCONSIN ALUMNI RESEARCH FOUNDATION (WARF)
WO_2026039749_PA

Resumen de: WO2026039749A1

Described herein are soluble HRC-based Hpopeptide inhibitors of coronaviruses identified using structure-guided design to incorporate charged or polar residues at specific sites in the peptide to enhance aqueous solubility. Also described are methods of treating a coronavirus infection using soluble HRC-based hpopeptide inhibitors.

SARS-COV-2 INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS

NºPublicación:  US20260049062A1 19/02/2026
Solicitante: 
INSILICO MEDICINE IP LTD [CN]
Insilico Medicine IP Limited
US_20260049062_A1

Resumen de: US20260049062A1

Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

SPECIFIC REACTION MIXTURE FOR USE IN THE DIAGNOSIS OF COVID-19 WITH ISOTHERMAL AMPLIFICATION METHOD

NºPublicación:  US20260049367A1 19/02/2026
Solicitante: 
ISTANBUL MEDIPOL UNIV [TR]
ISTANBUL MEDIPOL UNIVERSITESI
US_20260049367_A1

Resumen de: US20260049367A1

The present invention relates to a reaction mixture suitable for use in the diagnosis of Covid-19 by isothermal amplification method.

Therapy, treatment, and process for photodynamic inactivation of COVID-19

Nº publicación: US12551717B1 17/02/2026

Solicitante:

MCGRATH JR HUGH [US]
McGrath, Jr. Hugh

US_12551717_PA

Resumen de: US12551717B1

A therapy, treatment and process for inactivating and/or killing COVID-19 (Corona Virus Disease 2019) is provided, including a low-dose, full body, Ultraviolet A1 (UV-A1, 360-400 nm) photon therapy, wherein the UV-A1 photon therapy activates singlet oxygen (1O2), which inactivates and/or kills COVID-19. UV-A1 therapy of the present invention can also be used to help alleviate symptoms and secondary illnesses caused by COVID-19. UV-A1 therapy of the present invention can also be used to help alleviate and treat pre-existing conditions of people that are also suffering from COVID-19 and worsened by COVID-19.

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