Resumen de: WO2026216909A1
A method by which a computing device generates an electrocardiogram signal, according to one embodiment of the present disclosure, is disclosed. The method may comprise the steps of: acquiring a first type of electrocardiogram signal; utilizing a neural network model so as to generate a second type of electrocardiogram signal on the basis of the first type of electrocardiogram signal; evaluating the quality of the second type of electrocardiogram signal on the basis of the first type of electrocardiogram signal; and adjusting a parameter of the neural network model according to the evaluation result.
Resumen de: US20250099737A1
0000 Disclosed herein is a novel implantable transapical expandable heart pump with an extracorporeal motor, battery, and microprocessor that incorporates a valve. The pump can be placed through transapical puncture and does not require cutting the heart. The device can function in the left side of the heart expanding in the left ventricle and extending across the aortic valve to the ascending aorta; as well as the right side of the heart expanding in the right ventricle crossing the pulmonary valve into the main pulmonary artery. The device can replace full heart function when both sides are implanted.
Resumen de: EP4821540A2
A method of measuring the clearance of a dialyzer in a hemodialysis system comprising the dialyzer, the dialyzer comprising a semi-permeable membrane separating a first side of the dialyzer from a second side of the dialyzer, wherein the first side of the dialyzer is connected in line with a blood flow pathway of the hemodialysis system and the second side of the dialyzer is connected in line with a dialysate flow pathway of the hemodialysis system; the method comprising: creating flow of a first liquid through the blood flow pathway and a second liquid through the dialysate flow pathway; adding ions to either the first liquid or the second liquid to create a change in ionic strength of flowing liquid to which the ions have been added; passing the liquid to which the ions have been added through the dialyzer; measuring a parameter indicative of the ions added to the first or second liquid which pass across the semi-permeable membrane; and determining from the measured parameter a measure of the clearance of the dialyzer.
Resumen de: GB2705463A
An implant 4 functioning as both a bone fixation plate and a morphological filler, for orthognathic repositioning osteotomy of the upper or lower jaw such as a sliding genioplasty or Le Fort I maxillary advancement osteotomy, is custom designed according to imaging data of the patient’s pre-operative bone morphology, modified to accommodate the planned osteotomy in which one segment of the bone is repositioned to protrude beyond the other by subtracting the intersecting volume of the advancing bone segment from the virtual implant geometry, and manufactured from PEEK using 3d printing. A cutting and drilling guide is also custom designed to fit the pre-operative bone morphology and to include osteotomy cutting slots and mounting holes (5-6, Figs. 5-8) that will mark the locations of corresponding fixation screw holes 8 of the implant 4. Figure 13
Resumen de: EP4821428A2
0001 Digital and graphical user interfaces for multi-analyte monitoring systems are provided. For example, disclosed herein are various embodiments of methods, systems, and interfaces for alarm interfaces, alarm settings interfaces, alarm unavailability interfaces and features, and sensor results interfaces. Various embodiments of interfaces relating to glucose and ketone sensing are disclosed herein.
Resumen de: EP4821541A2
0001 The present invention relates to a computer-implemented method of monitoring neuromodulation progress of neuromodulation device treatment, the method comprising receiving from a user-interface device a user input about (i) a personalized objective of neuromodulation treatment for the patient or (ii) an intended manner of using the neuromodulation device by the patient, generating, via a controller circuit, a personalized treatment and device usage goal using the received user input, tracking, via the controller circuit, progress toward the personalized treatment and device usage goal based on patient state information, and initiating or adjusting a neuromodulation therapy via the neuromodulation device based on the tracked progress toward the personalized treatment and device usage goal.
Resumen de: US20250186713A1
A disposable fluid delivery system for an electrostatic applicator. The system includes a nozzle cap including a distal end including a delivery outlet and an open proximal end. A nozzle housing can be included with a proximal inlet end and an open distal end connected to the open proximal end of the nozzle cap. A conductive insert is at least partially positioned between the open distal end and the proximal inlet end and includes a portion of a flow pathway formed at least partially between the nozzle cap, the nozzle housing, and the conductive insert. A high voltage connector is extended at least partially through the nozzle housing and electrically connected to the conductive insert and configured to be in electrical communication with a high voltage module and electrostatically charge fluid contents within the flow pathway.
Resumen de: WO2025120669A1
The present disclosure provides a three-dimensional hydrogel prepared using a bioink composition comprising methacrylated hyaluronic acid, methacrylated gelatin, a photoinitiator and a photoabsorber; and a method for preparing the three- dimensional hydrogel or lenticule. The present disclosure further provides a method of treating corneal tissue repair in a subject in need thereof using the three- dimensional hydrogel or lenticule.
Resumen de: WO2025122635A1
An aerosol delivery device including a liquid supply, an electronically actuated droplet ejector in fluid communication with the liquid supply, and filter media or inertial filter points between the ejector and a droplets outlet to reduce the droplet size distribution of ejected droplets to smaller droplets exiting the droplets outlet.
Resumen de: MX373945B
An apparatus, system and method for regulating fluid flow are disclosed. The apparatus includes a curved, elongated support member elastically deformable and having first and second ends. The apparatus also include an opposing support member configured to position a tube against the curved, elongated support member between the first and second ends. Deformation of the curved, elongated support member by movement of the first and second ends toward each other reduces an internal volume of the tube.
Resumen de: EP4823109A2
1. A method for generating a digital three-dimensional image, the method comprising:driving each one of one or more structured light projectors to project a pattern on an intraoral three-dimensional surface;driving each one of one or more cameras to capture a plurality of images, each image including at least a portion of the projected pattern; andusing a processor to:compare a series of images captured by the one or more cameras;determine which of the portions of the projected pattern can be tracked across the series of images based on the comparison ofthe series of images; andconstruct a three-dimensional model of the intraoral three-dimensional surface based at least in part on the comparison of the series of images.
Resumen de: EP4822711A2
The present disclosure provides a healthcare management method comprising acquiring a first data that includes a glycoalbumin concentration and an albumin concentration in a body fluid from a subject; generating, on the basis of the first data, output information related to the GA value; and providing the generated output information to a user.
Resumen de: EP4821500A1
The present invention relates to mesenchymal stem cells isolated from the olfactory mucosa (OM-MSCs) and respective secretome (OMS) integrated with biomaterials such as Neural Guide Conduits/Tubes (NGCs) to promote peripheral nerve regeneration.Therefore, it is herein disclosed a process of isolating OM-MSCs and the respective secretome, cell lines, secretome and culturing media for said OM-MSCs and OMS.Also disclosed is a process to obtain biomaterials comprising integrated OM-MSCs and OMS into NGCs, products and uses thereof.The integration of biomaterials with the cells per se or secretome optimizes the microenvironment, enhancing cellular survival, proliferation, and targeted regeneration of nerve tissues.This invention is in the field of mesenchymal stem cells, biomaterials comprising such cells and peripheral nerve regeneration in humans or animals.
Resumen de: KR103032279B1
본 발명은 웨어러블 디바이스로부터 획득된 사용자의 생체 데이터를 인공지능 모델로 분석하여 사용자 상태 정보 및 사용자 상태 기반 발향 요구 프로파일을 생성하고, 발향 디바이스에 장착된 향 용기의 NFC 태그로부터 향의 권장 가열 온도, 안전 한계 온도 및 온도별 발향량 특성을 포함하는 향 프로파일을 획득하는, AI 감정 적응형 발향 서비스 제공 시스템 및 방법에 관한 것이다. 본 발명은 상기 온도별 발향량 특성에 기초하여 목표 발향량을 구현하기 위한 히터의 후보 목표 온도를 산출하고, 상기 후보 목표 온도가 상기 안전 한계 온도를 초과하는 경우 히터의 목표 온도를 상기 안전 한계 온도 이하로 제한하며, 그 제한에 따른 발향량 감소분을 산출하여 팬의 회전 속도, 구동 시간 및 구동 주기 중 적어도 하나를 증가시킴으로써 보상하는 발향 제어 프로파일을 생성한다. 이에 따라 서로 다른 안전 한계 온도를 가지는 향료가 교체 장착되는 경우에도 과열을 방지하면서 사용자 상태에 대응하는 발향량을 안정적으로 제공할 수 있다.
Resumen de: KR20260149999A
0001a 전자 장치의 동작 방법은 환자 및 의료인 사이의 진료 대화 정보가 획득되면, 기 설정된 알고리즘을 이용하여 제1 시간 구간 동안의 전사 데이터를 획득하는 동작, 획득된 제1 시간 구간 동안의 전사 데이터를 학습된 인공지능 모델에 입력하여, 분류된 진료 기록 정보 및 진단 코드 정보 중 적어도 하나를 획득하는 동작 및 획득된 분류된 진료 기록 정보 및 진단 코드 정보 중 적어도 하나를 포함하는 UI(User Interface)를 제공하는 동작을 포함한다.
Resumen de: WO2026216784A1
The present invention relates to an oral cleaner using a mouthpiece, wherein the mouthpiece is custom-made to fit the oral shape of each user and is configured to clean the teeth and gingiva while in close contact with the teeth, fissures, gingiva, boundaries between the teeth and the gingiva, and boundaries between the teeth of each user. To this end, the oral cleaner using a mouthpiece comprises a mouthpiece which has a plurality of cleaning grooves capable of accommodating a plurality of teeth, is designed, based on oral scan data of each user, to be in close contact with the teeth and gingiva of an individual user, and is made of a flexible material so as to enable the teeth and gingiva to be cleaned through friction with the cleaning grooves only by a user's chewing motion.
Resumen de: EP4822707A1
0001 The present disclosure relates to a computer-implemented method, system, and corresponding computer program product for measuring exudate spread in a wound dressing. The disclosed solution involves acquiring an image of the wound dressing and obtaining a size parameter from an identifier associated with the dressing, whereby the size parameter and the image are subsequently used to measure the exudate spread within the dressing.
Resumen de: US20250259516A1
A sensing system may include a sensor array comprised of a plurality of sensors coupled with a flexible circuit. Each sensor may include a sensing element and an analog-to-digital converter die coupled with the sensing element. The sensing element may include a sensor area coupled with a sensor die to generate an analog output based on sensing, and the analog-to-digital converter die may include circuitry to perform analog-to-digital conversion of the analog output to generate a digital output. The sensing system may further include a controller connected to the sensor array. The controller can cause a sensor of the sensor array to transmit a digital output that indicates sensing by the sensor in response to receiving a digital input. Other aspects are also described and claimed.
Resumen de: WO2022242800A2
A retainer (5) generally consists of a plurality of individual or optionally contiguous double wings (6). Each double wing (6) consists of a middle piece (7) and two wings (8), which laterally adjoin the middle piece and are designed for surface-to-surface adhesive bonding to the peripheral surface of a tooth (1, 2). This middle piece (7) is set, approximately at half the height of the tooth crown, between two teeth (1, 2), where the middle piece extends, as far as possible and sharply, into the gap between the teeth (1, 2). The two wings (8) follow the gingival margin (4) and end approximately in the sagittal plane (9) of a tooth. In order to produce a retainer (5), an electronic image of the intraoral side of a tooth-row contour is captured and said electronic image is used to produce a customized retainer (5), for example by means of a 3D printer or a 3D milling machine, i.e. for example to print or to mill the customized retainer. If the adhesive bond of a double wing (6) loosens over time, the adhesive bond of said double wing can be restored without the entire retainer (5) having to be detached from the teeth (1, 2). If a double wing is damaged or lost, the function of the retainer is substantially maintained even at the affected tooth.
Resumen de: US12758096B1
The in-home care of seniors is augmented using Internet of Things (IOT) technologies. In-home sensors monitor a senior and their caregiver. Physical conditions and psychological conditions may be monitored. In some implementations, a machine learning system has a classifier trained to detect a specified condition, such as depression. The system may perform various transformations of raw sensor data into a format indicative of a particular condition. In one implementation, a psychological or medical condition has symptoms in which each symptom has one or more measurable events. Mappings between symptoms, events, sensor data, and sensor transformation functions may be supported.
Resumen de: WO2025147736A1
A method of providing a personal drug injection system is disclosed. The method comprises determining at least one anthropometric characteristic from a person, and providing a plurality of types of personal drug injection systems. Each personal drug injection system of a personal drug injection system type is configured so as to fit with a part of the person's body that is intended to receive an injectable drug, and includes a drug injection location set that includes at least one defined drug injection location corresponding to a location of a drug injection site on the part of the person's body when the personal drug injection system is disposed on the part of the person's body. Each personal drug injection system type is associated with a defined range of anthropometric characteristics that is different to the defined range of anthropometric characteristics associated with the other personal drug injection system types, and each personal drug injection system type has an associated drug injection location set that is different to the drug injection location set of the other personal drug injection system types. The method also involves using the determined anthropometric characteristic and the defined ranges of anthropometric characteristics to select one of the personal drug injection system types from the plurality of personal drug injection system types already manufactured, and providing the person with the selected personal drug injection system type.
Resumen de: WO2025197838A1
The present invention assesses the risk of a neurodegenerative disease, and a precursor disorder for the neurodegenerative disease, using a saliva sample. An assessment device 10 comprises an inference unit 12 that inputs data of the saliva microbiome composition of a subject to each of a plurality of prediction models and obtains an inference result from each of the plurality of prediction models, and an assessment unit 13 that combines the plurality of inference results to assess the disease state of the subject. Each of the plurality of prediction models is machine-learned so as to stratify the disease state of the subject when inputting the data of the saliva microbiome composition of the subject using, as teacher data, the data of the saliva microbiome composition and the disease state of a neurodegenerative disease or a precursor disorder of the neurodegenerative disease. Each of the plurality of prediction models infers mutually different combinations of disease states.
Resumen de: US12762872B1
A method and a server for developing an orthodontic treatment plan for a subject are provided. The method comprising training a machine-learning algorithm (MLA) by: acquiring a 3D scan of an arch form of a training subject, identifying a first boundary geometry of a root portion of a given tooth by determining a contour of each cross-section of the root portion in a first anatomical plane; identifying a second boundary geometry of the root portion by determining a contour of the root portion in a projection thereof to at least one of a second and a third anatomical planes; analyzing the combination of the first and second boundary geometries to identify and remove image artefacts, thereby generating a final boundary geometry of the root portion; segmenting, in the 3D scan, the root portion of the given tooth along the generated final boundary geometry for further use in training the MLA.
Nº publicación: KR20260148605A 13/10/2026
Solicitante:
국립순천대학교산학협력단
Resumen de: KR20260148605A
0001a 3차원 미세토출 바이오프린팅 기술은 공압, 피스톤 또는 스크류를 사용하여 생체재료와 세포를 함유한 바이오잉크를 전달하고 토출하여 생물학적 조직과 장기를 프린팅한다. 전산유체역학(CFD) 해석은 제어 체적 내에서 바이오잉크의 유동 특성을 시뮬레이션할 수 있으며, 물리적 양을 계산하여 세포 생존율에 미치는 영향을 예측할 수 있다. 본 출원발명에서는 유변학적 분석과 CFD 해석을 통해 스크류 기반 디스펜서 시스템(SDS)이 바이오잉크 내 세포 생존율에 미치는 영향을 예측하는 분석 시스템을 개발했다. 또한, 고점도 바이오잉크의 실증적 평가를 위해 카르복시메틸셀룰로오스/알지네이트 기반 바이오잉크를 사용했다. 바이오잉크의 점도는 유변학적 측정을 통해 결정되었으며, CFD 분석을 위한 점도 계수는 비선형 회귀 분석에 의한 상관 방정식에서 도출되었다. 분석에서 도출된 질량 유량은 실증적 평가와의 비교를 통해 성공적으로 검증되었다. 마지막으로, C2C12 세포를 함유한 바이오잉크를 이용한 바이오프린팅 후 세포 생존율을 확인함으로써, 개발된 SDS가 생명공학 분야에 적용하기에 적합함을 시사했다. 결과적으로, 개발된 바이오잉크 분석 시스템은 다양한 시스템과 재료에 적용 가능하여 생명공학 산업에