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170
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Updated on
22/07/2025 [07:09:00]
Absstract of: CN120324678A
本发明公开了一种具有活性的骨缺损修复材料及其制备方法。所述骨缺损修复材料由动物来源提取的胶原蛋白、煅烧骨基质及骨形态发生蛋白复合微球复合，通过光固化3D打印技术成型制成。本发明从仿生角度出发，拟以胶原蛋白作为框架材料，以免疫原性低的煅烧骨基质作为硬质材料增强材料力学支持，并辅以骨形态发生蛋白复合微球协同作用，长效引导未分化间充质干细胞向特定方向发展。该活性骨缺损修复材料，植入骨缺损部位后，为细胞提供一个利于细胞粘附和增殖微观环境，同时骨形成发生蛋白的缓慢释放，能够长效作用于骨缺损部位，有效地推动成骨细胞分化成熟的过程，促进骨缺损部位的骨修复。
Absstract of: CN120326930A
本发明公开了纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用，其中，纳米羟基磷灰石/聚酰胺66复合材料的成型方法，包括：成型，采用熔融沉积成型的挤出式3D打印机对含纳米羟基磷灰石/聚酰胺66复合材料的料浆进行3D打印成型，得到打印件；后处理，对所述打印件依次进行干燥和退火，得到纳米羟基磷灰石/聚酰胺66复合材料的成型件。本申请利用3D打印可基于患者CT数据的三维重建技术可定制椎体假体形态，实现与复杂解剖结构的精确匹配，避免标准化椎体假体的局限性；还能够精确设计孔隙结构，而羟基磷灰石本身具备微观孔隙结构(<10μm)，从而使产品具备多级孔隙结构，有利于加速骨整合。
Absstract of: CN120326941A
本发明涉及牙冠制造技术领域，具体涉及基于人工智能的髓腔固位冠制造方法、系统，基于人工智能的髓腔固位冠制造方法包括：获取口腔CBCT影像与口扫模型；将口腔CBCT影像与口扫模型合成为合成模型；将合成模型输入训练后的AI模型，由AI模型基于合成模型生成髓腔固位冠模型；对髓腔固位冠模型做模拟受力测试，当髓腔固位冠模型的任意区域的应力大于预定值时，重新生成髓腔固位冠模型；对模拟受力测试合格的髓腔固位冠模型做模拟试戴测试；根据模拟试戴测试的结果调整髓腔固位冠模型；将调整后的髓腔固位冠模型输入打印装置并打印生成半成品髓腔固位冠；对半成品髓腔固位冠进行固化处理，生成成品髓腔固位冠。本申请提高了患者体验。
Absstract of: CN223111858U
本实用新型公开了3D打印金属植入物，包括植入物主体。本实用新型通过采用了顶部件、中部件、底部件，作业时，通过3D打印机可以分批次的将顶部件、中部件以及底部件进行3D生产出来，接着将生产出来的多组部件可以通过底部的限位环与顶部的定位槽进行对接就可以实现多组结构的初步连接操作，接着转动结构可以使得孔洞相互对齐，然后在孔洞中安装上紧固螺栓，通过紧固螺栓就可以实现多组结构的固定操作，由于构成植入物主体的结构采用模块化的设置，因此在生产过程中容错率大幅度提升，可以在某一部件出现不合格时针对性的进行替换生产，不需要整个结构进行重新生产，有效的提升了整体的使用灵活性以及实用性，具有生产容错率高、使用灵活的优点。
Absstract of: CN120324131A
本发明公开了一种FARSs的数字化设计及制作方法及FARSs，该方法包括：获取使用者静态的上下颌牙列数字化三维模型、颌骨数字化三维模型及下颌动态运动数据，并在CAD/CAM软件内进行拟合，以构建使用者的动态VDP模型；基于使用者的动态VDP模型，确定使用者的治疗颌位，并导出对应于各治疗颌位的数字化三维牙列模型；依据所导出的各治疗颌位对应的数字化三维牙列模型，在CAD/CAM软件内中完成牙合面具有解剖形态的FARSs的个性化设计；根据个性化FARSs的设计数据，使用3D打印技术一次性完成FARSs的制造。本发明制作的FARSs通过全数字化流程制作，相比传统前伸再定位咬合板，个性化位置精度高，贴合性好，舒适度高，可以改善咀嚼功能；其次，序列治疗降低治疗难度、减少患者复诊次数。
Absstract of: US2025228594A1
A method of manufacturing a surgical implant includes simultaneously forming a first component and a second component of the surgical implant. Formation of the first and second components includes depositing a first quantity of material to a building platform and fusing the first quantity of material to form a first layer of the first and second components. The method of manufacturing also includes depositing a second quantity of material over the first layer of the first and second components and fusing the second quantity of material to form a second layer of the first and second components. The surgical implant is fully assembled upon the completion of the formation of the first and second components.
Absstract of: US2025228647A1
An orthodontic teeth-straightener, comprising a splint element which contains, or is entirely made from, a thermoplastic polyurethane having shape-memory properties. The thermoplastic polyurethane having shape-memory properties is selected from the group of polyether polyurethanes and contains hard segments which contain polyurethane units that have been obtained by polyaddition of the isocyanate groups of a diisocyanate to the hydroxyl groups of a diol acting as a chain extender, thereby forming urethane groups. The polyether polyurethane also contains soft segments, which contain, or are entirely made from, polyether units in the form of polyalkylene glycols, wherein the polyether units are bonded to isocyanate end groups of the diisocyanate of the hard segments, thereby forming urethane groups with the hard segments. The thermoplastic polyether polyurethane is both thermo-responsive and water-responsive and thus gives the splint element dual-stimuli responsive shape-memory properties.
Absstract of: AU2023419073A1
The purpose of the present invention is to provide: a liquid with a pattern, said liquid including a pattern that can produce, in a liquid matrix, a sensation such as a color, a flavor, a texture, or a tactile sensation, said pattern having good stability; and a method for producing a liquid with a pattern which makes it possible to stably form a pattern in a liquid matrix. The present invention relates to, for example, a liquid with a pattern, said liquid including, in a liquid matrix, a pattern formed by microparticles and/or a pigment, wherein the liquid matrix is pseudoplastic fluid and is accommodated in a container.
Absstract of: US2025229463A1
A manufacturing system comprises a holder, a robot arm, a press and a laser. The holder is configured to receive a feature of a dental appliance and to hold the dental appliance by clamping the feature of the dental appliance, wherein the holder holds the feature of the dental appliance at a reference position. The robot arm is configured to retrieve an object and to place the object against the feature at the reference position. The press is configured to apply pressure to press the object against the feature of the dental appliance while the dental appliance is held by the holder. The laser is configured to expose an interface of the dental appliance and the object to coherent light to weld the object to the feature of the dental appliance while the press presses the object against the feature of the dental appliance.
Absstract of: US2025229006A1
The present invention relates to an artificial bile duct comprising ursodeoxycholic acid (UDCA), and due to comprising UDCA, the artificial bile duct of the present invention is effective in improving differentiation into cholangiocytes and preventing formation of bile stones.
Absstract of: US2025230391A1
A method, apparatus, and system are provided for the printing and maturation of living tissue in an Earth-referenced reduced gravity environment such as that found on a spacecraft or on other celestial bodies. The printing may be three-dimensional structures. The printed structures may be manufactured from low viscosity biomaterials.
Absstract of: EP4585185A2
The present invention relates to a method comprising forming a model of dental anatomy of a patient; and forming, based on the model, a removable dental appliance. The dental appliance comprises an appliance body configured to at least partially surround a plurality of teeth of a dental arch of a patient. The appliance body comprisies a unitary material defining a shell shaped to receive at least one tooth of the patient and a spring member integrally formed with the shell. The spring member is configured to receive an attachment, wherein the attachment is configured to affix to the at least one tooth, and wherein the spring member is configured to apply a spring force to the attachment to cause at least one of a rotation, a translation, a tipping, a torqueing, an extrusion, or an intrusion of the at least one tooth toward a desired position of the tooth when the removable dental appliance is worn by the patient.
Absstract of: CN119855708A
A method of manufacturing a transfer device includes providing a physical physical model having a shape corresponding to a positive shape of a patient's dental arch and one or more stent assemblies each including a lifting mechanism body releasably connectable to an orthodontic appliance. A transfer device may be formed over the physical entity model, wherein a transfer denture represents a negative replica of at least a portion of the entity model. The transfer device may be used to place the appliance on a patient's dental arch, after which the appliance may be detached from the lifting mechanism body and bonded to the associated tooth.
Absstract of: WO2023234310A1
This production method for a film preparation comprises: (1) a step for discharging a solution containing at least one pharmaceutical active ingredient from a print head to print the solution onto a soluble substrate film, the pharmaceutical active ingredient being printed onto the soluble substrate film so that the film includes a dose by which a desired effect is exhibited upon administration to a subject. The printed soluble substrate film can be formulated as a drug delivery system selected from a group including an injectable agent, a suppository, and a transdermal patch. The present invention also provides a production system for a film preparation, the system being for implementing the method.
Absstract of: EP4585184A2
The present invention relates to a system comprising an ordered set of removable dental appliances configured to reposition one or more teeth of a patient. Each removable dental appliance in the set of removable dental appliances comprises an appliance body configured to at least partially surround a plurality of teeth of a dental arch of a patient. The appliance body comprises a unitary material defining a shell shaped to receive at least one tooth of the patient and a spring member integrally formed with the shell, wherein the spring member is configured to receive an attachment. The attachment is configured to affix to the at least one tooth. The spring member is configured to apply a spring force to the attachment to cause at least one of a rotation, a translation, a tipping, a torqueing, an extrusion, or an intrusion of the at least one tooth toward a desired position of the tooth when the removable dental appliance is worn by the patient.
Absstract of: WO2024120579A1
The invention relates to a 3D fat tissue structure for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic reconstruction, construction or replacement of human breast tissue, wherein the 3D fat tissue structure has a matrix that is made of a biocompatible polymer and colonised with a plurality of biological cell types, wherein the colonisation with the plurality of cell types takes place during the construction of the matrix made of a biocompatible polymer, in the course of which a blood vessel structure network is formed within the 3D fat tissue structure, characterised in that, for the construction of the matrix made of a biocompatible polymer, light-based, structuring curing of a photopolymerisable or photocrosslinkable fluid is used. The invention also relates to the use of a 3D fat tissue structure as a breast implant in humans, wherein the 3D fat tissue structure has a matrix made of a biocompatible polymer, which is colonised with a plurality of cell types, wherein the colonisation with the plurality of cell types takes place during the construction of the matrix made of a biocompatible polymer, in the course of which a blood vessel structure network is formed within the 3D fat tissue structure, characterised in that, for the construction of the matrix made of a biocompatible polymer, light-based, structuring curing of a photopolymerisable or photocrosslinkable fluid is used.
Absstract of: AU2023293120A1
The disclosure is directed in part to polymerizable biocompatible or bioabsorbable compositions comprising styrene, N-vinylpyrrolidone or acrylate monomers, further comprising epoxide, urethane, polyether, or polyester oligomers and free radical initiators that can incorporate a radioactive source, including diagnostic or therapeutic radioisotopes and radioisotope precursors, to treat subjects with certain conditions, and methods of producing and use thereof.
Absstract of: CN120304980A
本发明涉及种植牙技术领域，具体而言，涉及一种锆铌合金种植件和锆铌合金种植件制作方法。该锆铌合金种植件包括种植体以及基台；种植体的外周配置有连接螺纹；种植体外表层为多孔骨小梁结构，多孔骨小梁结构采用三周期极小曲面结构，且其孔隙相互联通；种植体的外表面覆有锆铌合金金属陶瓷；种植体内部配置连接腔，连接腔内配置连接部；基台配置有用于与连接部可拆卸地连接的锥形连接台，基台在定量压力下压入种植体，在定量拉力下拔出基台。该锆铌合金种植件的种植体表面的多孔结构设计可促进骨组织长入，实现假体与人体骨骼界面的牢固整合，提高假体的稳定性和使用寿命，而且种植体与基台连接稳固，并能够降低金属过敏反应和金属伪影。
Absstract of: CN223095603U
本实用新型涉及医用辅助器械，一种悬空设计的3D打印脑部穿刺导板，包括导板本体；导板本体包括与患者的骨性生理特征相适配的眉弓固定曲面和鼻根固定曲面，鼻根固定曲面由眉弓固定曲面的中段下侧朝下延伸形成，导板本体整体呈T型；导板本体还包括鼻头固定曲面和鼻侧悬伸曲面；鼻头固定曲面由鼻根固定曲面的下部朝下延伸形成，且能够包覆在患者鼻头上；鼻头固定曲面的一侧朝左/右延伸形成有鼻侧悬伸曲面；本实用新型通过眉弓固定曲面、鼻根固定曲面、鼻头固定曲面等进行多点固定，多点固定的形式使得整体的固定更加的稳定，相较传统的简单通过皮肤贴附固定的方式而言，不易产生位移，能够保证穿刺导向的精准性，防止体表组织移动造成的干扰。
Absstract of: CN120305460A
本发明提供一种仿天然角膜纤维排列的超低溶胀人工角膜及制备方法，属于生物医用材料技术领域，本发明将I型胶原蛋白溶解于PBS缓冲液中，加入光功能化修饰的活性试剂进行化学修饰，避光搅拌后冷冻干燥，得到光功能化胶原蛋白；将光功能化胶原蛋白溶解，然后通过静电纺丝制备胶原纤维膜；将生物墨水和胶原纤维膜进行相变DLP 3D生物打印，获得胶原纤维夹层结构的人工角膜。本发明通过DLP 3D生物打印实现多层排列，模拟天然角膜的纤维走向，显著提升力学各向异性；GelMA/HA‑DN与光交联胶原纤维的复合相变DLP 3D打印方式，使其具有良好的可制造性，维持高透光率，同时保持高力学强度。
Absstract of: CN120305453A
本发明公开了一种纳米纤维纱线3D打印复合支架的制备方法，所述制备方法包括以下步骤：S1：将纺丝所需聚合物和/或无机源溶于对应溶剂，得到纺丝前驱体溶液；S2：使用步骤S1所述的纺丝前驱体溶液采用纳米纤维纺纱设备进行纺纱，得到纳米纤维纱线；S3：利用3D打印技术打印得到聚合物框架；S4：将S2中所述的纳米纤维纱线在S3所述聚合物框架中进行编织，得到纳米纤维纱线3D打印复合支架。该制备方法制备得到的支架不仅具有3D打印的几何结构，还具有纳米纤维的高比表面积和生物活性，能够更好地模拟天然组织的微环境，可以克服传统支架的局限性，提供了更理想的组织工程支架。
Absstract of: CN120307644A
本申请实施例适用于齿科技术及3D打印技术领域，提供了一种用于生成牙齿模型的方法、牙齿模型打印方法及设备，所述用于生成牙齿模型的方法包括：获取口腔扫描模型，所述口腔扫描模型包括扫描杆模型；确定与所述扫描杆模型匹配的接合装置模型；从所述口腔扫描模型移除所述扫描杆模型，并基于与所述扫描杆模型的位置匹配，添加所述接合装置模型，以生成牙齿模型。应用本方法，可以通过数字化方式获得患者口腔数据，进而根据匹配的接合装置模型生成牙齿模型，实现精确取模。在此基础上，本申请实施例可以采用3D打印技术打印获得相应的实体牙齿，降低人工装配带来的误差，保证打印得到的实体牙齿的精度。
Absstract of: CN120305040A
本发明公开了一种药物缓释型医用敷贴，包括聚氨酯薄膜，聚氨酯薄膜其中一面经过激光刻蚀处理，在聚氨酯薄膜上刻蚀出载药槽；药物负载于缓释骨架上，构成药物‑骨架负载结构，药物‑骨架负载结构负载于载药槽内。本发明医用敷贴中的药物负载于缓释骨架上，缓释骨架通过三维微纳打印制备得到，缓释骨架的形状根据载药槽的形状进行定制，使载药槽内缓释骨架的数量最大化，药物负载于缓释骨架上，从而载药槽内可以容纳更多的药物，提升医用敷贴的载药量，且药物‑骨架负载结构，可以起到良好的缓释效果，使用7天后仍具有释药能力，从而大大提高了医用敷贴的利用率和耐久性，避免了换药过程中的二次创伤，有利于创面修复。
Absstract of: WO2024076590A2
Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.
Nº publicación: CN120304981A 15/07/2025
Applicant:
广州黑格智造信息科技有限公司
Absstract of: CN120304981A
本申请实施例适用于齿科技术及3D打印技术领域，提供了一种制造种植牙模的方法和3D打印系统，该方法包括：获取具有替代体接口的种植牙模模型；基于所述种植牙模模型，通过3D打印制造由树脂构成的种植牙模。其中，上述替代体接口可以包括螺纹状的连接结构。采用上述方法，可以解决包含替代体的牙模在与基台装配时存在的问题，降低装配难度，提高牙模与基台的装配精度。
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