Absstract of: US20260102230A1
A method and device for aligning face scans with intraoral scans in dentistry applications. Digital intraoral scans capture the upper and lower arches and a bite registration. An Anterior Extension Device is affixed in the patient's mouth. A working scan of the upper arch scan is trimmed to remove the areas covered by the Anterior Extension Device. A rigid reference link extends between the Anterior Extension Device and base of the patient's nose. The working scan is rescanned to include the Anterior Extension Device and rigid reference link and patient's nose. A facial scan is taken while the patient is smiling. The rescanned working scan is aligned and merged with the facial scan on the basis of at least three points of reference on the patient's nose. A prosthetic device is designed using in combination the intraoral scans aligned with the facial scan.
Absstract of: US20260102758A1
The subject invention pertains a stable, three-dimensional (3D) photocatalyst composition comprising TiO2 doped with carbon derived from lignin. The photocatalyst composition has a stable, hollow, spherical or spheroid nanoparticle structure, which improves photodegradation under visible light irradiation over unmodified TiO2 photocatalysts. The subject invention also provides methods of preparing the photocatalyst, as well as methods using the photocatalyst to remediate contaminants such as pharmaceuticals, pathogens and persistent organic pollutants.
Absstract of: US20260102102A1
The present disclosure applies to methods of cardiac ablation that use an algorithm to determine where in the heart a driver of atrial fibrillation is located. Catheters with multi-electrode arrays are used to measure electrograms from cardiac signals wherein abnormal signals are identified as electrogram deflections with characteristic shapes. The electrogram deflections are compared to each other in pairs to determine which came first in time in order to determine the net direction of propagation of a fibrillatory wave. The signal that came first is assigned a positive point value so that once the plurality of electrograms have been compared, the signal with the highest point value can be identified as a driver of fibrillation. The data can be displayed graphically as a map of atrial fibrillation drivers on a 3D representation of a heart, allowing surgeons to quickly and easily identify where on the heart the driver is.
Absstract of: WO2026080633A1
The present disclosure provides synthesizing multi-functional polymerizable compounds and methods for the synthesizing the same. The methods include reacting a compound of Formula (Ia) with an epoxide of Formula (Ib) with quantitative conversion, requiring only an aqueous work-up for purification. Further provided herein are methods of producing polymerizable composition, methods of forming an article by additive manufacturing processes (e.g., via 3D printing), such as orthodontic appliances with increased stain resistance.
Absstract of: WO2026080101A2
The portable sensor system (100) includes a containment portion (102) and a sensor portion (104). The containment portion (102) may include a shipping container such as a jar. The sensor portion (104) may include a cap (106) that may be selectively coupled with the containment portion (102). The cap (106) may include a battery module (108), a processing module (110), and a sensor module (112). In a specific example, the portable sensor system (100) may be provided in four layers (a battery module layer (108), a processing module layer (110), a sensor module layer (112), and a coupling mechanism layer (114). The coupling mechanism layer (114) may be configured to selectively lock the cap (106) to the containment portion (102). In a more specific example, one or more of the layers (108, 110, 112, 114) may be 3D printed. The portable sensor system (100) may be utilized as a smart-monitoring device for the presence of a pathogenic bacteria in the shipping container.
Absstract of: US20260102564A1
0000 A system for programming infusion devices for target controlled infusion is disclosed. The system includes a docking station and one or more processors configured to determine a first infusion device docked with a docking station and accept user input of one or more of patient-specific parameters, drug-related parameters, and a desired target concentration of a therapeutic agent in a workflow on the first infusion device for programming a target controlled infusion (TCI) therapy. After receiving a particular set of parameters, the set of parameters can be copied to the second infusion device to pre-complete and bypass a number of workflow steps of a second workflow of another infusion device. When the second workflow is accessed, the number of workflow steps of the second graphical interface workflow are pre-completed and bypassed.
Absstract of: AU2025215643A1
A system (100) may include a donor supply sub-system (110) configured to supply donor material (102) to a donor substrate (104). The system may include a material transfer sub-system (108) comprising a laser (200) configured to illuminate the donor substrate via a transfer beam (202). The system may include an instrument head (302) of a medical instrument (300) configured to house the donor substrate, wherein upon an illumination of the donor substrate, the donor material is transferred to receiver material in vivo.
Absstract of: US20260102656A1
0000 A computer-implemented method for providing real-time performance feedback includes receiving uncalibrated time-series motion data generated by one or more motion sensors coupled directly or indirectly to an athlete while performing a downhill snow sport, the motion sensor(s) having an unknown rotational orientation relative to the athlete; determining an estimated rotational offset of the motion sensor(s) relative to a body-segment coordinate frame of the athlete, the rotational offset determined using a calibration model; transforming, by the one or more processors, the uncalibrated time-series motion data to calibrated time-series motion data according to the estimated rotational offset, the calibrated time-series motion data aligned with the body-segment coordinate frame; and processing the calibrated time-series data, with the one or more processors, to determine one or more metrics for the athlete.
Absstract of: US20260105597A1
Systems and methods for generating a patient-specific vascular tree are provided. 1) one or more medical images of a patient and 2) a vascular tree template comprising a plurality of points are received. The plurality of points of the vascular tree template are iteratively adjusted based on the one or more medical images using one or more AI (artificial intelligence) agents to generate a patient-specific vascular tree for the patient. The patient-specific vascular tree is output.
Absstract of: US20260102135A1
A computer-implemented method for manufacturing an X-ray bone phantom is provided. The computer-implemented method includes obtaining, via a processing system comprising one or more processors, dual-energy scan data from one or more dual-energy scans of an ex vivo bone phantom. The computer-implemented method also includes converting, via the processing system, the dual-energy scan data into a two-dimensional image. The computer-implemented method further includes printing, via the processing system, a semi-anthropomorphic X-ray bone phantom made of aluminum based at least on the two-dimensional image, wherein the semi-anthropomorphic X-ray bone phantom is configured to provide quantitative areal bone mineral density and a realistic projected bone morphology for image quality assessment and lateral distance measurements during calibration.
Absstract of: US20260102276A1
0000 A dental article of manufacture comprising a first appliance, and a second appliance. The first appliance fits dentition of a patient’s lower dental arch, and the second appliance fits dentition of the patient’s upper dental arch. The first appliance has a first feature positioned at its midline and located at a given distal offset with respect to an incisal edge when fitted on the lower dental arch. Preferably, the second appliance has a second cooperating feature positioned at its midline and includes a closed cavity having a front-facing opening. The second feature is designed to mate with the first feature. To this end, the second feature is positioned to removably receive the first feature only through the facing opening. In use, the second feature retains the first feature in the closed cavity against backwards and up or down movement when the second appliance is fitted on the upper dental arch.
Absstract of: US20260105213A1
In some embodiments systems and methods are provided for an automated system for generating an appliance for a body part that utilizes artificial intelligence and machine learning to identify points in a scan, generate a surface from the identified points, and generate the appliance for the body part.
Absstract of: WO2026078555A1
A method of designing a patient-specific surgical item comprising: obtaining, by one or more processors, a 3-dimensional (3D) item model representing at least a surface of a patient-specific surgical item that is shaped to conform to one or more anatomical structures of a patient; determining, by the one or more processors, a size of a 3D primitive shape and a position of the 3D primitive shape such that the 3D primitive shape is collocated with a protrusion artifact of the 3D item model; modifying, by the one or more processors, the 3D item model to exclude portions of the 3D item model collocated with the 3D primitive shape; and generating, by the one or more processors, output data based on the modified 3D item model.
Absstract of: US20260102224A1
0000 Materials, methods, and systems for additive manufacturing are provided. In some embodiments, a method includes: forming a mixture including a first thermoplastic polymer powder separated from a first additively manufactured dental appliance manufactured during a first powder bed fusion process, where the first thermoplastic polymer powder has a characteristic particle size distribution and a characteristic melt volume rate; in a second powder bed fusion process, depositing a powder layer of the mixture, where the powder layer has a powder packing consistency dependent on the characteristic particle size distribution of the first thermoplastic polymer powder; and in the second powder bed fusion process, applying energy to the powder layer to melt the powder layer to form a part layer of a second additively manufactured dental appliance, where the part layer has a material consistency dependent on the characteristic melt volume rate of the first thermoplastic polymer powder.
Absstract of: WO2026079532A1
The present invention relates to a printer for cosmetics that can easily form clear design patterns on the surfaces of cosmetic materials, the printer for cosmetics comprising: a support part for supporting at least one cosmetic material; a header part that includes an ejection port for ejecting an ink composition onto the surface of the cosmetic material and is configured to reciprocate along a first direction; and a first heating part and a second heating part which have the header positioned therebetween and are arranged along a second direction that forms a predetermined angle with respect to the first direction.
Absstract of: WO2026079874A1
Disclosed is a method for 3D modeling a customized oral appliance for improving sleep disorders according to various embodiments of the present invention. The method comprises the steps of: generating a dental model including an upper jaw model and a lower jaw model; generating contour information on the basis of the dental model; generating a plurality of part models on the basis of the contour information; and generating an oral device model by integrating the plurality of part models.
Absstract of: AU2024337161A1
A device providing ocular photo-bio-stimulation therapy, a biological technique to control or influence the activity of neurons or other cell types in, on or about the eye with light. As used herein ocular photo-bio-stimulation is an umbrella category of which photobiomodulation, optogenetics and phototherapy are forms thereof. The current invention relates, in part, to photobiomodulation therapy, which includes the utilization of nonionizing electromagnetic energy to trigger photochemical changes within cellular structures. The current invention relates, in part, to optogenetics. Optogenetics is a biological technique to control the activity of neurons or other cell types with light. The current invention relates, in part, to phototherapy, also known as light therapy or bright light therapy, which is a treatment that uses controlled exposure to artificial or natural light to treat medical conditions.
Absstract of: US20260106042A1
Detecting neurotoxicity associated abnormalities due to certain medication therapies can be significant for identifying various neurological disorders. The present disclosure relates to detection of neurotoxicity related disorders by leveraging an interface including one or more sets of queries and a set of components to receive a set of responses corresponding to the sets of queries. The techniques, as disclosed herein, may use one or more attributes of the set of responses including consistency, complexity, grammar and spelling correctness, and time taken during the responses. The disclosed technique may preprocess the responses, extract features and generate one or more metrics corresponding to the one or more attributes of the one or more responses provided by the subject during a session with the interface. The generated metrics over a baseline session and subsequent sessions may be used to determine trends in the metrics which may be used to estimate the extent of neurotoxicity developed by a subject and may trigger an alert about a potential neurotoxicity or a preventative measure to reduce a likelihood of further neurotoxicity.
Absstract of: AU2025234210A1
A method for examining visible skin conditions is shown. A housing (101) is located at a region of a visible skin condition and image data of the skin over this region is captured. Electric fields (2001, 2002) are generated that penetrate the skin over the region, such that an application of the apparatus produces both image-related signals and electric field related signals for the same skin condition. Depth of skin penetration of the visible skin condition may be assessed by calculating the surface area of the visible skin condition from the image data and determining the volume of the visible skin condition from the electric field related signals and processing the calculated surface area in combination with the determined indication of volume to assess the depth of skin penetration. The electric field generating device may comprise a first dielectric substrate (301) having a hole (302) and the capturing step may be performed by a camera (501) viewing the visible skin condition through this hole. A method for examining visible skin conditions is shown. A housing (101) is located at a region of a visible skin condition and image data of the skin over this region is captured. Electric fields (2001, 2002) are generated that penetrate the skin over the region, such that an application of the apparatus produces both image-related signals and electric field related signals for the same skin condition. Depth of skin penetration of the visible skin condition may be assessed by cal
Absstract of: US20260102612A1
A method for generating a transducer layout for delivering tumor treating fields includes storing medical images of a subject, identifying one of the medical images as an anchor medical image, and registering computed tomography medical images with magnetic resonance imaging medical images. The method further includes segmenting abnormal tissue in the medical images from other tissue types and defining a region of interest (ROI) in the medical images. The method further includes creating a 3D model of the subject. The method further includes generating a plurality of transducer layouts for application of tumor treating fields to the subject, selecting at least two of the transducer layouts as recommended transducer layouts, presenting the recommended transducer layouts, receiving a user selection of at least one recommended transducer layout, and providing a report for the selected recommended transducer layout(s).
Absstract of: US20260105608A1
0000 Systems and methods are provided for processing image data generated by a medical imaging system such as an ultrasound or echocardiogram system using artificial intelligence and machine learning to determine a presence of one or more congenital heart defects (CHDs) and/or other cardiovascular anomalies in the image data in a manner that is agnostic to the type of imaging system, software, and/or hardware. Image data from various types imaging systems, software, and/or hardware, having various styles of imaging data generated may be processed to determine image styles. Input image data for analysis may then be processed together with representative styles of image data to generate styled input images for each style. The styled input images may be processed by an image analyzer to detect one or more cardiovascular anomalies in the styled image data, for example. Alternatively, training data may be styled and used to train the image analyzer.
Absstract of: WO2024251724A1
The invention relates to a method for producing a first connection element of a removable dental prosthesis, said connection element being suitable for a sliding connection between a first fit surface of the first connection element and a second fit surface of a second connection element of the removable dental prosthesis. The invention is characterized in that the first connection element is produced by connecting a stability-granting material and a ductile material which forms the first fit surface in an additive multi-material manufacturing method.
Absstract of: WO2024254134A2
The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having at least one coating layer provide drug storage and drug release tor the treatment of various diseases, disorders, or conditions, One aspect of the present invention includes a packaged medical device including a medicament. Another aspect of the present invention includes a drug delivery contact lens. A farther aspect of the present invention includes a. method of making a drug delivery contact lens. An additional aspect of the present invention includes a method of using a drug delivery contact lens. A further aspect of the present invention includes a medical device including bimatoprost and N-vinylpyrrolidone.
Absstract of: WO2024252292A1
The bio-printed skin model (1) comprises: - at least one dermal layer (2) comprising at least one polymer matrix and a mixture of fibroblasts and endothelial cells and configured to simulate a human dermal tissue; - at least one epidermal layer (3) comprising at least one mixture of keratinocytes and configured to simulate a human epidermal tissue; wherein the dermal layer (2) comprises at least one inner duct (4) formed by fibroblasts and endothelial cells, configured to simulate a vascular channel of human skin and provided with at least two end stretches communicating with the outside and connectable to a system for active perfusion of substances.
Nº publicación: EP4725400A1 15/04/2026
Applicant:
OURA HEALTH OY [FI]
Absstract of: EP4725400A1
Methods, systems, and devices for optical signal measurement are described. A wearable electronic device may activate a first combination of optical sensors, the first combination of optical sensors including a set of transmitter sensors and a set of receiver sensors. In some cases, one or more optical sensor of the first combination of optical sensors may be positioned under a protrusion on an inner surface of the wearable electronic device. The device may measure, at the set of receiver sensors at a first time, one or more signals from the set of transmitter sensors, determine a signal quality metric associated with the one or more signals, and select a second combination of optical sensors for use at a second time based on the signal quality metric.