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METHODS FOR DETERMINING ATTACHMENT PLACEMENT APPLIANCE GEOMETRY

Publication No.:  US2025331953A1 30/10/2025
Applicant: 
ALIGN TECH INC [US]
Align Technology, Inc
US_2025331953_PA

Absstract of: US2025331953A1

Methods for determining appliance geometry are provided. In some embodiments, a method includes determining a geometry for an attachment placement appliance. The attachment placement appliance can include an appliance body including a support formed in a tooth-receiving cavity for a tooth of a patient, one or more coupling structures connected to the support, and an aligner attachment connected to the one or more coupling structures. The aligner attachment can be configured to be mounted on the tooth and shaped to engage with an attachment well of a shell aligner and exert forces on the tooth when the aligner attachment is coupled to the attachment well. The appliance body can be configured to align an aligner attachment to a predetermined location on the tooth. The method can further include generating instructions for direct fabrication of the attachment placement appliance via an additive manufacturing process, based on the determined geometry.

SURGICAL SHAFT INSTRUMENT AND METHOD FOR PRODUCING A SURGICAL SHAFT INSTRUMENT

Publication No.:  WO2025223804A1 30/10/2025
Applicant: 
PAROTH CHRISTEL [DE]
HENNINGER ALEXANDER [DE]
COMBROWSKI ZBIGNIEW [DE]
PAROTH, Christel,
HENNINGER, Alexander,
COMBROWSKI, Zbigniew
WO_2025223804_PA

Absstract of: WO2025223804A1

The invention relates to a surgical shaft instrument (1) with at least one jaw part (30) which is movable in at least one axis (X) and by means of which a preferably pliers-like or scissors-like tool is formed in a distal end region (9), comprising a first part (10) having a first shaft portion (20) along a shaft axis (L); a second part (40) having a second shaft portion (50) along the shaft axis (L) and a second guiding means (42) in the distal end region (9); and at least one jaw part (30) which is provided on the first part (10) in the distal end region (9), said at least one jaw part (30) having a first guiding means (32) and being provided as a single piece. The first part (10) and the second part (40) are combined such that the first guiding means (32) and the second guiding means (42) interact in such a way that when the first shaft portion (20) and the second shaft portion (50) are mutually displaced, the at least one jaw part (30) is deflected about the at least one axis (X). The invention also relates to a method for producing the surgical shaft instrument (1).

MANUFACTURING ALIGNERS HAVING COORDINATE SYSTEM REFERENCE MARKS

Publication No.:  US2025331954A1 30/10/2025
Applicant: 
ALIGN TECH INC [US]
Align Technology, Inc
US_2025331954_PA

Absstract of: US2025331954A1

A method of fabricating a dental appliance includes receiving a 3D model of a mold for a dental arch of a patient, the digital three-dimensional model of the mold comprising one or more features associated with one or more coordinate system reference marks, and fabricating the mold by a rapid prototyping machine using the digital three-dimensional model, the mold having the one or more features. The method further includes thermoforming the dental appliance over the mold, wherein the one or more features cause the dental appliance to have the one or more coordinate system reference marks. The method further includes orienting, by a trimming machine, a coordinate system of the trimming machine with a coordinate system of the dental appliance using the one or more coordinate system reference marks, trimming, by the trimming machine, the dental appliance along a cut line according to a digital file comprising trimming instructions.

ORTHODONTIC DEVICE AND PROCESS OF MANUFACTURING ORTHODONTIC DEVICE

Publication No.:  US2025331960A1 30/10/2025
Applicant: 
ORNGE ORTHODONTICS INC [US]
Ornge Orthodontics Inc
US_2025331960_PA

Absstract of: US2025331960A1

An orthodontic device includes an alignment body, a support member, and a positioning mechanism connecting the support member to the alignment body. The support member includes a bracket receiving structure and is actuatable between a bonding position and a non-bonding position. A process of manufacturing an orthodontic device includes constructing an orthodontic device from data including a three-dimensional model obtained from a patient's dentition, an orthodontic prescription, and a structure of an orthodontic bracket including a bonding surface.

LEAD CONSTRUCTION INCLUDING ALIGNABLE MARKER ELEMENTS

Publication No.:  US2025332406A1 30/10/2025
Applicant: 
MEDTRONIC INC [US]
MEDTRONIC, INC
US_2025332406_PA

Absstract of: US2025332406A1

Implantable apparatus includes two or more alignable marker elements, and systems and methods for manufacturing such implantable apparatus, and methods to utilize such implantable apparatus. For example, the implantable apparatus may include a first alignable marker element and a second alignable marker element that may be used to ensure proper alignment with a target site.

SURGICAL STAPLER CARTRIDGE WITH 3D PRINTABLE FEATURES

Publication No.:  US2025331850A1 30/10/2025
Applicant: 
CILAG GMBH INT [CH]
Cilag GmbH International
US_2025331850_PA

Absstract of: US2025331850A1

An apparatus includes a staple, a body, a staple driver, and an alignment feature. The alignment feature is coupled to or formed with at least one of the staple driver or an inner surface of the staple aperture of the body. The alignment feature is configured to minimize rotation of the staple driver. The alignment feature includes at least one of a first contact feature, an alignment member, an alignment member, or an inwardly tapering portion. The first contact feature projects beyond a first lateral side of the staple driver. The alignment member extends through at least a portion of the staple driver. The first connecting portion rigidly connects the inner surface of the staple aperture with the staple driver in a connected state. The inwardly tapering portion of the inner surface or the staple driver is configured to guide the staple driver.

Nonconductive Field Guide For Resection Cavity, And Systems And Methods Of Using Same

Publication No.:  US2025332412A1 30/10/2025
Applicant: 
NOVOCURE GMBH [CH]
NOVOCURE GMBH
US_2025332412_PA

Absstract of: US2025332412A1

A method for treating tumor cells around a resection cavity comprises positioning a nonconductive material within a resection cavity that is adjacent to a target region. At least a first electrode and a second electrode are positioned relative to the tumor resection cavity so that electric fields between the at least one first electrode and the at least one second electrode travel through the target region. Tumor-treating electric fields are the generated between the at least one first electrode and the at least one second electrode.

MAGNETIC CUP ASSEMBLY

Publication No.:  US2025332067A1 30/10/2025
Applicant: 
NORTHSTAR MEDICAL TECH LLC [US]
Northstar Medical Technologies, LLC
US_2025332067_PA

Absstract of: US2025332067A1

A magnetic cup includes a first cup portion including a first magnet and a second cup portion including a second magnet. A target capsule is placed between the first cup portion and the second cup portion. The target capsule is sealed with a first seal. The magnetic cup provides a second seal formed from a magnetic force between the first magnet and the second magnet. Further provided is a tool designed to assist a user for opening the magnetic cup. The tool includes a first arm including a third magnet designed to attract the first magnet through a second magnetic force greater than the first magnetic force, and a second arm including a fourth magnet designed to attract the second magnet through a third magnetic force greater than the first magnetic force.

COMPLIANT SUPPORT MECHANISM

Publication No.:  US2025334162A1 30/10/2025
Applicant: 
LEINWAND JONAH [CA]
MCLACHLIN STEWART [CA]
LEINWAND Jonah,
MCLACHLIN Stewart
US_2025334162_PA

Absstract of: US2025334162A1

There is disclosed a compliant support mechanism including a first support surface; a second support surface; and one or more flexure prongs arranged in a configuration therebetween, each flexure prong having a plurality of bends or curves along its length so as to allow the configuration of one or more flexure prongs to be resiliently compliant when subjected to external forces on the support surfaces. The one or more flexure prongs have a compliance profile dependent upon the application.

FENESTRATION TEMPLATE FOR ENDOVASCULAR REPAIR OF AORTIC ANEURYSMS

Publication No.:  US2025332794A1 30/10/2025
Applicant: 
UNIV OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION [US]
University of Washington through it's Center for Commercialization
US_2025332794_PA

Absstract of: US2025332794A1

To provide simple yet accurate stent graft fenestration, a patient-specific fenestration template is used as a guide for graft fenestration. To generate the fenestration template, a patient's medical imaging data such as CT scan data may be used to generate a 3-D digital model of an aorta lumen of the patient. The aorta lumen may encompass one or more branch vessels, which may be indicated on the 3-D digital model. Based on the 3-D digital model or a segment thereof, the fenestration template may be generated, for example, using 3-D printing technology. The fenestration template may include one or more holes or openings that correspond to the one or more branch vessels. To fenestrate a stent graft, the fenestration template is coupled to the stent graft so that the holes or openings on the fenestration template indicate the fenestration locations.

COLLAGEN-BASED FORMULATIONS USABLE AS SOFT TISSUE FILLERS AND/OR IMPLANTS

Publication No.:  FI4126088T3 30/10/2025
Applicant: 
COLLPLANT LTD
CollPlant Ltd
FI_4126088_T3

Absstract of: US2023310704A1

A three-dimensional (3D) biocompatible, degradable soft tissue implant, comprising a bioprinted composite scaffold, the composite scaffold comprising a recombinant human collagen (rhCollagen) and a biocompatible synthetic polymer and features: a porous wall; an inner cavity at least partially enclosed within the porous wall; and at least one injection port that connects the inner cavity with an outer most surface of the scaffold, wherein the injection port has an opening sized to permit insertion of an injection device through the port, processes of preparing same and uses thereof in soft tissue reconstruction are provided. Injectable matrices for use in soft tissue reconstruction, either alone or in combination with the implant are also provided.

METHOD AND APPARATUS FOR PRINTING ORTHODONTIC BRACKETS USING ULTRA FINE 3D PRINTING RESOLUTION AND VARIABLE LAYER THICKNESS

Publication No.:  WO2025226761A1 30/10/2025
Applicant: 
PEARL DIGITAL INC [US]
PEARL DIGITAL INC
WO_2025226761_PA

Absstract of: WO2025226761A1

The present invention relates to a method and system for fabricating customized orthodontic brackets using 3D printing technologies with ultra-fine resolution to produce the orthodontic bracket with multiple layer thicknesses, and each layer thickness ranges from 0.05 micrometers to 100 micrometers. The process involves accessing data related to a 3D CAD bracket structure model for the customized orthodontic bracket. The 3D printing technologies with adaptive slicing dynamically adjust layer thickness based on geometric complexity and surface roughness, ensuring the variable layer ranges from 0.05 micrometers to 100 micrometers. By applying variable layer thickness, the method optimizes surface roughness.

SYSTEMS, METHODS, AND DEVICES FOR PLAQUE ANALYSIS, VESSEL AND FLUID FLOW ANALYSIS, AND/OR RISK DETERMINATION OR PREDICTION THEREOF

Publication No.:  WO2025226727A1 30/10/2025
Applicant: 
CLEERLY INC [US]
CLEERLY, INC
WO_2025226727_PA

Absstract of: WO2025226727A1

This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.

FLEXIBLE EXOSKELETON WITH PNEUMATIC ARTIFICIAL MUSCLE

Publication No.:  WO2025226163A1 30/10/2025
Applicant: 
UNIV DE INGENIERIA Y TECNOLOGIA [PE]
UNIV NACIONAL DE TRUJILLO [PE]
INSTITUTO NAC DE SALUD DEL NINO SAN BORJA [PE]
UNIVERSIDAD DE INGENIER\u00CDA Y TECNOLOG\u00CDA,
UNIVERSIDAD NACIONAL DE TRUJILLO,
INSTITUTO NACIONAL DE SALUD DEL NI\u00D1O SAN BORJA
WO_2025226163_PA

Absstract of: WO2025226163A1

The present invention relates to a flexible exoskeleton having a suit with one or more pneumatic artificial muscles, wherein the pneumatic artificial muscle comprises: a flexible membrane; internal rings spaced apart from one another and wrapped inside the flexible membrane; and external rings that are coupled to the internal rings from the outside of the flexible membrane. The rings and the clips may be manufactured, for example, by means of 3D printing and the membrane may be a thin plastic film or a fabric.

PROCESS FOR OBTAINING A NEUROPROTECTIVE CONDUIT WITH CONTROLLED RELEASE OF BIOACTIVE MOLECULES FOR NERVE REGENERATION, NEUROPROTECTIVE CONDUIT AND USES THEREOF

Publication No.:  WO2025222266A1 30/10/2025
Applicant: 
UNIV ESTADUAL DE CAMPINAS [BR]
UNIVERSIDADE ESTADUAL DE CAMPINAS
WO_2025222266_PA

Absstract of: WO2025222266A1

The present invention relates to a process for obtaining a biocompatible neuroprotective conduit with controlled release of bioactive molecules for nerve regeneration, comprising the steps of: 3D printing an NGC and guide tube from PCL biomaterial; sterilising the NGC; preparing GelMA functionalised with the growth factor FGF-2; inserting the guide tube into the NGC; applying GelMA functionalised with the growth factor FGF-2; photocrosslinking with a UV light head; and removing the guide tube. Furthermore, the present invention also relates to a biocompatible neuroprotective conduit with controlled release of bioactive molecules for nerve regeneration and to uses thereof.

改良されカスタマイズされた隣接歯間接触部を有する歯科用マトリックスのデジタル設計

Publication No.:  JP2025535838A 29/10/2025
Applicant: 
ソルベンタムインテレクチュアルプロパティズカンパニー
JP_2025535838_PA

Absstract of: US2024325127A1

Systems and techniques for designing a digital dental matrix with improved interproximal contacts are disclosed including generating a digital three-dimensional model of a future dental anatomy of a patient, the future dental anatomy representing an intended shape of at least one tooth of the patient, selecting one or more pairs of adjacent teeth in the 3D model, for each selected pair of teeth, determining a location and orientation in the interproximal space of the adjacent teeth to insert a digital 3D geometry having one or more initial parameters, and inserting the digital 3D geometry at the determined location and orientation.

BIOENGINEERED CORNEAL GRAFTS

Publication No.:  EP4637631A1 29/10/2025
Applicant: 
PRECISE BIO 3D LTD [IL]
Precise Bio 3D Ltd

DISPOSITIVOS PARA IMPLANTAR EN EL CUERPO HUMANO Y MÉTODO PARA SU FABRICACIÓN

Publication No.:  AR133733A1 29/10/2025
Applicant: 
TECRES S P A [IT]
TECRES S.P.A
WO_2025052207_A1

Absstract of: WO2025052207A1

Temporary and/or disposable device that can be implanted in the human body, including a biocompatible material implantable in the human body and including a plastic material, wherein the material includes a pharmaceutical or medical substance including at least one antibiotic and/or a radio-opacifying agent; method for the obtainment of such device and thread of 3D-printing material for the obtainment of such device.

NEBULISER

Publication No.:  EP4637883A1 29/10/2025
Applicant: 
3C PROJECT TECH LIMITED [IE]
3C Project Technologies Limited
KR_20250125411_PA

Absstract of: CN120529970A

The present disclosure provides an apparatus (100) for aerosolizing a liquid, the apparatus comprising one or more inputs (110) and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet injector includes a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with one or more inputs. Each piezoelectric actuator is operable to cause liquid received by one of the one or more inputs to be ejected through a respective nozzle outlet in the form of one or more droplets, thereby producing an aerosol comprising the one or more droplets ejected by each droplet ejector.

METHOD AND DEVICE FOR PRODUCING AN ARTICLE

Publication No.:  EP4638095A1 29/10/2025
Applicant: 
OTTOBOCK SE & CO KGAA [DE]
Ottobock SE & Co. KGaA
DE_102022134212_PA

Absstract of: WO2024133131A1

The invention relates to a method for producing a three-dimensional article by way of an additive manufacturing method, wherein at least one manufacturing material is introduced in a flowable state into a support material from at least one introduction opening of an introduction needle and is then hardened, and a stiffening material is introduced into the support material and then hardened.

APPARATUS FOR AEROSOLISING A LIQUID

Publication No.:  EP4638018A1 29/10/2025
Applicant: 
3C PROJECT TECH LIMITED [IE]
3C Project Technologies Limited
KR_20250125411_PA

Absstract of: CN120529970A

The present disclosure provides an apparatus (100) for aerosolizing a liquid, the apparatus comprising one or more inputs (110) and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet injector includes a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with one or more inputs. Each piezoelectric actuator is operable to cause liquid received by one of the one or more inputs to be ejected through a respective nozzle outlet in the form of one or more droplets, thereby producing an aerosol comprising the one or more droplets ejected by each droplet ejector.

A METHOD FOR PRODUCING A THREE-DIMENSIONAL MICROPOROUS FILAMENT CONSTRUCT

Publication No.:  EP4638040A1 29/10/2025
Applicant: 
VITO NV [BE]
VITO NV
CN_120265403_PA

Absstract of: CN120265403A

A method for producing a three-dimensional macroporous filament construct having interconnected microporous filaments comprises: a) preparing a mixture comprising particles of one or more metals, one or more metal alloys, or a combination thereof, one or more binders, a first liquid solvent of the one or more binders, and optionally one or more dispersants; b) dispersing particles containing at least one removable additive in the mixture; c) depositing the mixture in the form of filaments in a predetermined three-dimensional pattern of interconnected filaments, thereby producing a filament-based three-dimensional porous green structure; d) contacting the filament-based three-dimensional porous green structure formed in step c) with a second solvent, which is a non-solvent for the one or more binders, to induce phase inversion, thereby producing a filament-based phase-inverted porous structure having filament micropores, thereby converting at least a portion of the filaments into a solid state; e) removing the at least one removable additive by dissolution in a remover to create additional micropores in the phase-inverted porous structure; f) subjecting the structure thus obtained to a heat treatment. The remover contains or consists of the second liquid solvent, or the remover is a third liquid solvent different from the second liquid solvent.

BIOMATERIAL FOR USE IN THE DENTAL FIELD

Publication No.:  EP4637673A1 29/10/2025
Applicant: 
INST REGIONAL CANCER MONTPELLIER [FR]
UNIV MONTPELLIER [FR]
CENTRE NAT RECH SCIENT [FR]
ENSCM [FR]
INST NAT SANTE RECH MED [FR]
CT HOSPITALIER UNIVERSITAIRE MONTPELLIER [FR]
Institut R\u00E9gional du Cancer de Montpellier,
Universit\u00E9 de Montpellier,
Centre National de la Recherche Scientifique,
Ecole Nationale Sup\u00E9rieure de Chimie de Montpellier,
Institut National de la Sant\u00E9 et de la Recherche M\u00E9dicale,
Centre Hospitalier Universitaire de Montpellier
CN_120615008_PA

Absstract of: AU2023410422A1

The present invention relates to a crosslinkable polymer composition comprising at least one calcium phosphate, at least one biocompatible and biodegradable organic polymer or one of its precursors, and Zn-ZnO core-shell particles, to a biomaterial obtainable by photopolymerization of such a crosslinkable polymer composition, to a process for preparing such a composition and such a biomaterial, and to the use of such a biomaterial for various applications in the field of health.

一种磷酸钙人工骨单元及其成型装置

Publication No.:  CN120840078A 28/10/2025
Applicant: 
合肥美迪普医疗卫生用品有限公司
CN_120840078_PA

Absstract of: CN120840078A

本发明公开了骨修复材料技术领域的一种磷酸钙人工骨单元及其成型装置,该成型装置包括打印组件、平台以及用于驱动打印组件和/或平台移动的三轴伺服组件,其中,平台上设有若干个通过熔融物粘连支撑骨单元的支撑机构、用于回收熔融物的抽吸装置、以及用于调节支撑机构和抽吸装置位置的调节装置,通过设置管体以及加热固态熔融物的方式对骨单元进行支撑,其作用力维度更多,具有支撑力、拉力、剪切力,并且可以通过再次加热脱离粘连,以便于在骨单元打印更高时,换到其他位置进行粘连支撑;且通过设置抽吸装置,可以回收多余的液态熔融物,有效缓解其顺骨单元流下的问题。

MEW組織足場

Nº publicación: JP2025535820A 28/10/2025

Applicant:

ジユニバーシティオブウェスタンオーストラリア

JP_2025535820_PA

Absstract of: CN120548152A

A fused electrowriting soft tissue stent comprising: a first region having one or more groups of fibers and a second region having one or more groups of fibers; and an interface region joining the first region and the second region, the interface region being electrically written with the first region and the second region in a continuous print path such that fibers in the interface region are each joined between respective pairs of fibers in the first region and the second region.

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