Alerta

SYSTEMS AND METHODS FOR RAPID LIQUID BIOPRINTING

Absstract of: US2025270502A1

Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.

STRETCHABLE SELF-HEALING HYDROGEL

Absstract of: US2025270389A1

The present invention relates to a stretchable self-healing hydrogel. The hydrogel has excellent mechanical properties and stability, and stretchable and self-healing properties, and can be useful as a hydrogel for delivery of a drug or a cell, and a composition for 3D bioprinters.

COLLAGEN BIOMATERIAL DERIVED FROM ABALONE

Absstract of: US2025270291A1

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.

Referenzkörper zum Bestimmen der Abschwächung von Röntgenstrahlung und Verfahren zu dessen Herstellung

Absstract of: DE102024105696A1

Die Erfindung betrifft einen Referenzkörper (1) zum Bestimmen einer Abschwächung von Röntgenstrahlung durch ein mittels Röntgenstrahlung untersuchtes Objekt, wobei der Referenzkörper (1) eine zusammenhängende Matrix (2) aus einem Kunstharz mit zugesetztem Röntgenkontrastmittel aufweist. Um einen Referenzkörper (1) anzugeben, welcher in einer Röntgenaufnahme sowohl eine hohe Röntgenkontrastauflösung, als auch eine hohe Ortsauflösung erlaubt, wird vorgeschlagen, dass die Matrix (2) 3D-gedruckt wird, wobei mindestens ein erster Bereich (3, 4, 5, 6,7) und ein zweiter Bereich (3, 4, 5, 6 7) der Matrix (2) definiert werden, indem das Röntgenkontrastmittel dem Kunstharz in dem ersten Bereich (3, 4, 5, 6, 7) in einer ersten definierten Konzentration und in dem zweiten Bereich (3, 4, 5, 6, 7) in einer von der ersten definierten Konzentration abweichenden zweiten definierten Konzentration zugesetzt wird, so dass der erste Bereich (3, 4, 5, 6, 7) einen ersten definierten Röntgenkontrast mit einer ersten CT-Zahl aufweist, welche sich von einer zweiten CT-Zahl eines zweiten definierten Röntgenkontrasts des zweiten Bereiches (3, 4, 5, 6, 7) um mindestens 1 HU unterscheidet.

SYSTEMS FOR POST-PROCESSING ADDITIVELY MANUFACTURED OBJECTS WITH SENSOR FEEDBACK

Absstract of: US2025269599A1

Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a rotor configured to support a plurality of additively manufactured objects having excess material thereon. The system can further include an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects. The system can further include a sensor configured to obtain sensor data indicative of a cleaning status of the plurality of additively manufactured objects while the plurality of additively manufactured objects remain on the rotor. The system can further include a controller configured to adjust, based on the sensor data, an operational parameter of the rotor that enhances removal of the excess material from the plurality of additively manufactured objects.

METHODS FOR 3D PRINTING OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS

Absstract of: US2025269585A1

Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HIB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.

COUPLING MEMBER, FLOW PATH CONNECTION MECHANISM, AND INKJET RECORDING APPARATUS

Absstract of: US2025269656A1

A coupling member includes a valve housing and a hollow movable valve. Relative to the valve housing, the hollow movable valve is positionally displaced in an axis direction between a position in a connected state where the coupling member is connected to another coupling member and a position in a disconnected state where the coupling member is disconnected from the other coupling member, thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap is generated between a prescribed part of the hollow movable valve and the valve housing in a radial direction. The hollow movable valve has a circulation opening penetrating through the prescribed part in the radial direction.

SYSTEMS AND METHODS FOR GENERATING DIRECTLY MANUFACTURABLE DENTAL APPLIANCES

Absstract of: CN120076767A

Systems, methods, and devices are provided for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances. In some embodiments, a method includes receiving a treatment plan for teeth of a patient, the treatment plan specifying a target arrangement of teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method may include identifying appliance design parameters of one or more dental appliances for performing at least one of a plurality of treatment phases. The appliance design parameters may include one or more manufacturability parameters corresponding to an additive manufacturing process to be used for directly manufacturing the one or more dental appliances. The method may also include determining an appliance geometry of the one or more dental appliances using the set of appliance design parameters.

AN AQUEOUS BIOINK SOLUTION FOR USE IN LIGHT-BASED BIOPRINTING APPLICATIONS, AND METHODS OF USING THE AQUEOUS BIOINK SOLUTION

Absstract of: CN120091914A

The present disclosure relates to an aqueous bio-ink solution for light-based bioprinting applications comprising: (a) from 0.5% to 95% by weight of a water-soluble prepolymer; (b) from 0.001% to 5% by weight of a biocompatible metal acyl phosphinate photoinitiator; (c) from 0.001 wt% to 10 wt% of a biocompatible light absorber; and (d) from 5% to 99.5% by weight of a solvent. The present disclosure also relates to methods of using aqueous bio-ink solutions containing living cells and methods of using aqueous bio-ink solutions free of living cells (cell-free).

PROCESS FOR THE MANUFACTURING OF MICROSCALE HOLLOW METAL BODIES

Absstract of: WO2024083825A1

A hollow body and a process for preparing a hollow body having a bottom, an upper end wall and side walls extending between the bottom and the upper end wall, characterized in that the upper end wall and side walls are made of metal, the cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter and the upper end wall comprises at least one opening. The hollow body are suitable for encapsulating small amounts of liquid, or of very small micro-electromechanical system, may be used for the controlled release of pharmaceutical components.

PHOTOPOLYMERIZATION INITIATOR

Absstract of: EP4606824A1

An object of the present invention is to provide a photopolymerization initiator that is hardly affected by inhibition by oxygen, has good photoinitiating property in air, has high sensitivity to long-wavelength light, and can suppress odor and bleed-out problems of a cured product to be obtained.A photopolymerization initiator having one or more benzophenone groups and one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms in a molecule, wherein one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms are bonded to one or more carbon atoms of an aryl group of one or more benzophenone groups through a carboxylic acid ester group or a carboxylic acid amide group.

COUPLING MEMBER, FLOW PATH CONNECTION MECHANISM, AND INKJET RECORDING APPARATUS

Absstract of: EP4606583A1

A coupling member (1) includes a valve housing (12) and a hollow movable valve (101). Relative to the valve housing (12), the hollow movable valve (101) is positionally displaced in an axis direction between a position in a connected state where the coupling member (1) is connected to another coupling member (2) and a position in a disconnected state where the coupling member (1) is disconnected from the other coupling member (2), thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap (G) is generated between a prescribed part of the hollow movable valve (101) and the valve housing (12) in a radial direction. The hollow movable valve (101) has a circulation opening (1010) penetrating through the prescribed part in the radial direction.

POLYMERIC STRUCTURES HAVING A MICRO-VOID SPACE AND SYSTEMS AND METHODS FOR MAKING SAME

Absstract of: CN120225338A

Aspects of the present disclosure include methods for making polymer structures having microvoid spaces. A method according to certain embodiments includes irradiating a polymerizable composition positioned between a build lift table and a build surface to produce such polymerizable composition, the polymerizable composition has: a polymerized region of the polymerizable composition having a microvoid space in contact with a build lift table and a non-polymerized region of the polymerizable composition in contact with a build surface; removing the build lift from the build surface; contacting the generated microvoid space with a non-reactive composition; and repeating in a manner sufficient to create a polymer structure having a clearly discernible microvoid space. Systems for preparing polymer structures according to the subject methods are also described. Also provided are polymer structures having clearly discernible microvoid spaces, such as where the microvoid spaces are filled with a non-polymerizable composition.

PROGRAMMABLE INTRAMEDULLARY IMPLANTS AND METHODS OF USING PROGRAMMABLE INTRAMEDULLARY IMPLANTS TO REPAIR BONE STRUCTURES

Absstract of: EP4606354A1

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an intermedullary implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.

一种义齿3D扫描仪

Absstract of: CN223263037U

本实用新型涉及扫描仪技术领域，具体为一种义齿3D扫描仪，包括底座、固定架、放置台、安装架和扫描装置；固定架连接底座上端，安装架连接固定架，安装架设有滑轨，扫描装置滑动连接滑轨，扫描装置上设有限位组件，限位组件与安装架配合连接；底座转动设有用于调节放置台高度的升降机构，底座设有驱动机构传动连接升降机构，底座设有用于夹持义齿的夹持机构，夹持机构位于放置台的两端。本实用新型中通过转动的放置台和夹持机构使义齿可以全方面扫描，不需要多次调节提高扫描效率。

一种牙周辅助加速正畸手术专用导板

Absstract of: CN120531507A

本发明公开了一种牙周辅助加速正畸手术专用导板，该专用导板包括颊侧就位导板和合面就位导板、以及位于颊侧就位导板上的多个导向管，颊侧就位导板上设置有一体成型的定位销且合面就位导板上设置有一体成型的定位槽，合面就位导板套置在上颌和/或下颌的牙列上，与合面就位导板配套的颊侧就位导板上的定位销插入对应的定位槽内；所述的导向管位于牙列唇侧、牙龈软组织的外侧且排列在每个牙位的近中邻面和远中邻面处，导向管限定了支抗钉手柄工作头部的钻入位置、钻入方向和钻入深度。本发明导板使用后的创口为针状大小，患者不易出现术后水肿、强烈的炎症反应以及牙根吸收等情况，安全性强、操作方便、定位精准、费用便宜，适用于大多数正畸病例。

软组织重建植入物及其形成的方法

Absstract of: AU2025203084A1

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure (101) of the implant is at least 50 %.

一种耐蚀高超弹性增材制造镍钛合金及其制备方法与应用

Absstract of: CN120536767A

本发明公开了一种耐蚀高超弹性增材制造镍钛合金及其制备方法与应用。所述制备方法包括增材制造成型、前处理、表面处理三个步骤。本发明采用纳秒脉冲激光重熔的方法，利用特定范围内参数优化了增材制造镍钛合金表面质量，通过纳秒脉冲激光重熔工艺的精确热物理调控，重熔层形成了细小均匀的等轴晶粒结构，而基层则保留柱状晶粒，提高了整体超弹性效应；并促使其在腐蚀过程中形成稳定的钝化膜，有效抑制基体镍释放，提高了其耐蚀性。本发明所述制备方法具有精确可控、加工效率高和适用性广的优点，适宜推广应用。

动态水凝胶组合物

Absstract of: AU2023375461A1

Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.

正畸放置装置及其制造方法，口腔装置及其制造方法

Absstract of: EP4537787A2

Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.

联结部件、流道连接机构和喷墨记录装置

Absstract of: CN120534078A

本发明提供联结部件、流道连接机构和喷墨记录装置。联结部件包括：阀箱体；以及中空可动阀，配置在阀箱体的径向内侧，相对于阀箱体可在轴向上移位，通过在联结部件和其他联结部件被连接的连接状态时和连接被解除的连接解除状态时使中空可动阀相对于阀箱体的轴向的位置移位，从而中空可动阀在连接状态时使液体流通，而在连接解除状态时限制液体的流通，在连接状态时，在径向上的中空可动阀的预定部分与阀箱体之间产生间隙，中空可动阀具有在径向上贯通预定部分的流通口。

一种基于多模态神经网络的口腔3D建模打印方法、系统及相关装置

Absstract of: CN120531488A

本申请提供一种基于多模态神经网络的口腔3D建模打印方法及系统，属于口腔医学技术领域，首先基于图像传感器获取目标视频，将目标视频输入训练好的第一神经网络模型，基于第一神经网络模型的输出结果，确定强磨合区域数据，最后，获取初始模型数据，将初始模型数据与强磨合数据输入训练好的第二神经网络模型，基于第二神经网络模型的输出结果，确定目标建模数据。本申请实施例提出的一种基于多模态神经网络的口腔3D建模打印方法及系统，通过动态视频中运动数据驱动3D打印模型的咬合面形态设计，在正畸治疗的过程中预判组织变化，用历史病例训练预测网络，较人工测试咬合更精准，通过预测高磨损区域并提前增材设计降低牙冠碎裂或种植体松动率。

一种3D打印个性化骨骼夹板外固定装置及其制作方法

Absstract of: CN120531544A

本发明公开了一种基于3D打印的个性化骨骼夹板外固定装置及其制作方法，属于医疗器械技术领域。本发明包括固定主体及紧固件螺丝螺栓。所述固定主体可分为两部分，每部分纵向均设有四个调节部位。调节部位包括尼龙螺丝、尼龙螺母和底座，尼龙螺丝贯穿上下两夹板的底座连接螺母，通过旋转螺母调节夹板的松紧。所述外固定手臂夹板主体呈多边形不规则镂空状，保证了其具有较好的透气性。所述外固定手臂夹板由3D scanner扫描建模并测量具体数据，利用熔融沉积型3D打印机制成。其中3D打印机参数设置如下：控制打印喷头温度为190~220℃，打印底板温度为20~50℃，打印速度为20~40mm/s，冷却风扇转速为2000~2500rpm。打印机所使用的线材由超高分子量聚乙烯通过单螺杆挤出机制成。采用超高分子量聚乙烯保证了所述外夹板具有较高的抗冲击性能，固定效果好，有利于患者部位的稳定愈合。

一种用于后巩膜加固的光敏树脂及其制备方法与应用

Absstract of: CN120535735A

本发明公开了一种用于后巩膜加固的光敏树脂及其制备方法与应用。其制备方法包括以下步骤：将碳酸乙烯酯与异佛尔酮二胺混合反应生成非异氰酸酯聚氨酯；向非异氰酸酯聚氨酯加入己内酯，反应得到聚己内酯基聚氨酯二醇；在聚己内酯聚氨酯二醇溶液中添加三乙胺，再添加甲基丙烯酸酐进行反应，纯化，得到聚己内酯基聚氨酯光敏树脂。制得的聚己内酯基聚氨酯光敏树脂具有良好的生物相容性和力学性能，应用于后巩膜加压手术中，对后巩膜加压效果良好，OCT结果显示出现明显加压嵴。

数字化和柔性压力传感器结合的大腿假肢接受腔优化制造方法

Nº publicación: CN120531531A 26/08/2025

Applicant:

之江实验室

Absstract of: CN120531531A

本发明公开了一种数字化和柔性压力传感器结合的大腿假肢接受腔优化制造方法。大腿残肢物理模型的数字化重建；对重建后的残肢构面数字模型空间标定和尺寸校准处理；对空间标定和尺寸校准后的残肢构面数字模型稀疏化处理并进行编辑和优化；将稀疏点云数字模型和帽檐、坐托的数字点云模型进行拼接成大腿假肢数字模型；设置柔性压力传感器压力分析调整局部片段厚度，生成外层表面形成双面稀疏点云的假肢接受腔数字模型，最后转换进行3D打印。本发明利用柔性传感单元与数字化皮肤上的点云单元相对应，进行静态和动态下肌肉受力的实时变化评估，能够在再次检查时能够快速适应患者的生理变化，提供更为个性化和及时的康复解决方案。