Alerta

MEDICAL TISSUE WRAP

Absstract of: AU2023370241A1

The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

METHODS AND DEVICES FOR IMPROVED EEG SOURCE IMAGING AND IMPROVED ELECTROSTIMULATION OF THE BRAIN

Absstract of: EP4548847A1

Several methods and devices are proposed for improved electroencephalography source imaging (ESI) and/or improved and tailored electrostimulation. The approach is based on an electrode helmet (1) that carries a set of electrodes (2) at precisely known and predefined spatial positions, in particular because each electrode (2) is held in place by a respective electrode holder (4) of the helmet (1). As the helmet (1), in particular said electrode holders (4), can be 3D-printed based on 3D design data which are based on patient-specific 3D anatomical data, the helmet (1) offers a platform for patient-specific recording of EEG signals and/or electrostimulation. Accordingly, tedious 3D optical scanning of each electrode (2) position is no longer necessary, such that highly accurate ESI and electrostimulation are possible as soon as the patient is wearing the helmet (1) in the intended well-defined orientation on his head (cf. Figure 2).

PHOTOCROSSLINKABLE RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Absstract of: WO2024002806A1

Recombinant bacterial collagen-like protein with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 characterized in that the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1 and that the recombinant collagen-like protein is functionalized with ethylenic unsaturated groups.

3D PRINTING TRANSPARENT BIOINK FORMULATION

Absstract of: WO2024003287A1

Bioink comprising modified fibers of MFC with a diameter of about 100-400 nm.

制造牙齿替代品部件的方法、适配器、坯件以及由适配器和坯件组成的套件、由多个适配器组成的套件

Absstract of: WO2024126460A1

A method for producing a dental restoration part (200), in particular a fixed dental restoration part (200), that can be connected to a tooth stump (110), wherein an adapter (10) for a machine tool and a blank (50) for the dental restoration part (200) is produced.

基于框架结构支架的组织工程一体化气管再生构建方法及应用

Absstract of: CN119925691A

本发明公开了基于框架结构支架的组织工程一体化气管再生构建方法及应用。基于3D打印生物弹性体框架结构支架构建多组织结构一体化气管，高度模拟天然气管的复杂结构和生理功能。首先利用温敏水凝胶Pluronic F‑127在37℃下成半固态凝胶，4℃低温下液化的特性，采用温敏水凝胶占位后牺牲的策略，实现了软骨细胞和成纤维细胞在二维平面上图案化分布。其次通过2D到3D的卷合组装策略，模拟三维管状气管结构，并在裸鼠皮下实现C形软骨环/O形纤维环交替分布式及轴向条状纤维束三重结构的有序再生。最后成功提取气道黏膜上皮并在体外分离扩增出足量的气道基底细胞，利用光交联水凝胶将其负载到再生气管内壁，实现气道上皮功能仿生，增强生理功能性。

一种基于3D打印导板的腰椎置钉导航定位系统及方法

Absstract of: CN119924980A

本发明提供一种基于3D打印导板的腰椎置钉导航定位系统及方法，涉及医疗手术导航技术领域，包括：获取腰椎图像；对腰椎图像进行预处理；构建基于卷积神经网络的椎体识别模型；将预处理后的腰椎图像输入至椎体识别模型进行椎体识别，确定腰椎图像中每个椎体的类别以及形状；通过3D打印技术，设计与腰椎图像中各个类别的椎体的形状对应的3D打印导板；获取手术过程中3D打印导板图像；对3D打印导板图像进行预处理；构建基于卷积神经网络的导孔识别模型；将预处理后的3D打印导板图像输入至导孔识别模型进行导孔识别，确定3D打印导板上的各个导孔的位置；根据3D打印导板中的各个导孔的位置，进行腰椎置钉手术的导航定位。

用于3D打印的图层图像提供方法及用于实现其的装置

Absstract of: WO2024076024A1

A method performed by a computing system, according to one embodiment of the present disclosure, comprises the steps of: determining a masking area of a current layer on the basis of a non-overlapping area between the current layer and at least one previous layer from among a plurality of layers; and updating an image of the current layer in accordance with a user input for setting a light exposure amount with respect to the masking area of the current layer, wherein the plurality of layers are designed to sequentially cure a photocurable material in each layer unit for 3D printing.

一种生物钛合金-羟基磷灰石梯度复合材料及其喷射成形方法

Absstract of: CN119927228A

本发明公开了一种生物钛合金‑羟基磷灰石梯度复合材料及其喷射成形方法，所述生物钛合金‑羟基磷灰石梯度复合材料由合金相和陶瓷相组成，所述合金相为β型钛合金，所述陶瓷相为羟基磷灰石，所述生物钛合金‑羟基磷灰石梯度复合材料具有三维梯度结构，集合了β型钛合金与自然骨更匹配的力学性能、良好的抗蚀耐磨性及生物相容性等特点，和羟基磷灰石良好的生物活性和骨传导性等特点。本发明提供的喷射成形方法包括粉末浆料制备、浆料喷射成形、成形坯的脱脂和烧结等步骤，喷射成形方法实现了β型钛合金‑羟基磷灰石复合材料的三维梯度结构，并可实现个性化且高精度制造梯度复合材料骨修复植入体。

一种高精度数字化全口义齿3D打印方法

Absstract of: CN119925017A

本发明涉及义齿制作技术领域，且公开了一种高精度数字化全口义齿3D打印方法，包括以下步骤：得到目标对象的初始义齿模型；获取咬合点调整数据；获取实际调整数据；基于实际调整数据对初始义齿模型进行调整，并转换为3D打印指令后进行3D打印；有利于通过利用有限元分析模拟咬合时应力分布，获取三维咬合热力图，并输入至构建好的CNN网络模型中，获取咬合点调整数据，并将有效咬合接触点的调整数据映射至实体模型中，获取实际调整数据；通过扫描仪获取患者口腔三维数据，并结合神经网络模型进行数字化分析，提高义齿制作精度，并采用3D打印方式进行制作，制作效率高、患者佩戴舒适感和咬合好，及时解决种植患者的饮食困难问题。

由用于准备人的咬合平面的迁移、特别是永久迁移的装置组成的套件及相关方法

Absstract of: WO2023222192A1

The invention relates to a series (100) comprising devices for assisting in the displacement of the occlusal plane of a person (P), said series comprising at least two devices (10), the devices (10) each comprising at least one jaw device (11, 12), the at least one jaw device (11, 12) comprising an upper jaw device (11) and/or a lower jaw device (12), and the devices (10) being designed to be worn by the person (P) according to a predefined order. In at least one device (10.1, 10.2), the at least one jaw device (11, 12) has at least one height element on a first side. At least two contact regions, preferably local contact regions, are formed on the at least one height element at different positions of molar elements. At least one additional contact region, in particular an additional local contact region, is formed on a second side of the at least one jaw device (11, 12). The at least three contact regions define the plane (GE), wherein the plane (GE) differs from a starting occlusal plane of the person (P) or from a current occlusal plane of the person (P) with respect its inclination, modified by the at least one height element, in a frontal section or sagittal section and/or with respect to its height position modified by the at least one height element, and wherein, in at least one other device of the series (100), a different inclination in a frontal section or sagittal section and/or a different height position of the plane is adjusted by at least one additional height

一种基于3D打印的具有中药穴位刺激的脊柱侧凸矫形装置

Absstract of: CN222828712U

本实用新型公开了一种基于3D打印的具有中药穴位刺激的脊柱侧凸矫形装置，属于医疗器械技术领域。它包括矫形器本体和刺激器，矫形器本体根据患者脊柱侧凸的外形结构、中医所选取的脊柱侧凸处的穴位位置以及功能影像数据经3D打印而成，刺激器根据中医具体脊柱侧凸严重程度以及相对舒适度经3D打印而成，刺激器通过魔术贴安装在矫形器本体上，刺激器的内部设有储药腔，储药腔内设置有药物，刺激器的一端部设有透药孔，储药腔与透药孔相连通。本实用新型中利用3D打印技术所制作的矫形器本体，能够与由3D打印技术所打印的带有透药孔的刺激器搭配使用，改善现有矫形器仅仅矫形的作用，提高矫正效果和患者的舒适感。

一种特殊晶格结构的腕部3D打印康复支具及其制备方法

Absstract of: CN119925059A

本发明公开了一种特殊晶格结构的腕部3D打印康复支具及其制备方法，属于医疗康复支具技术领域，包括通过3D打印技术制备的腕部支具、指部支具以及指套，腕部支具、指部支具和指套之间可拆卸连接，腕部支具和指部支具的内部均设置有充气囊，腕部支具和指部支具的连接件具体为可向两者内部充气囊进行充气的紧固卡扣，本发明支具具备蜂窝状、网格状或梯形支撑结构，通过计算机辅助设计（CAD）与优化算法，实现支具在保证强度的前提下大幅减轻重量，支具表面设有多个透气孔，结合拓扑结构本身的网格特性，确保良好的通气性能，避免长时间佩戴时产生闷热和不适，且可根据康复进程调整不同区域的支撑强度，便于拆装和清洁。

一种3D打印的微针贴片及其制备方法和应用

Absstract of: CN119925310A

本发明涉及一种3D打印的微针贴片及其制备方法和应用，所述制备方法包括以下步骤：(1)将明胶溶液与甲基丙烯酸酐混合，透析，冷冻干燥，获得甲基丙烯酸化明胶；(2)将药物溶液与甲基丙烯酸化明胶混合，3D打印成型。本发明提供了一种无创、便捷的给药方式，微针贴片针尖具有较强穿刺力，同时可以有效减少穿刺时的痛感，并提高药物传递的精准性。

一种用于光固化增材制造的光敏树脂及其制备的陶瓷浆料

Absstract of: CN119930936A

本发明公开了一种用于光固化增材制造的光敏树脂及其制备的陶瓷浆料，按重量份计，其组成为：预聚物7份~50份，单官能度单体3份~100份，低官能度单体30份~95份，高官能度单体0.5份~50份，分散剂0.4份~10份，光引发剂0.01份~5份，塑化剂2份~20份，光吸收剂0.01份~0.11份和/或阻聚剂0.01份~1.5份；其中预聚物占光敏树脂总重量的15%以上。本发明光敏树脂粘度低，同时使制备的浆料具有低粘度特性，且打印件具有光滑表面；能够抑制X/Y平面过曝，提高光固化精度；能有效解决打印生坯变形问题，及有机物分解排除引发的开裂等问题，陶瓷生坯密度高，可打印薄壁结构。

一种光固化组合物、导电柔性膜层及柔性压力传感器

Absstract of: CN119931243A

本发明提供了一种光固化组合物、导电柔性膜层及柔性压力传感器，将包括柔性光敏树脂、光引发剂和修饰改性的碳纳米管的光固化组合物，利用3D打印技术制备得到的导电柔性膜层以及柔性压力传感器。本发明的导电柔性膜层即使在经历大幅度弯曲后，仍能维持其导电性能，本发明制备的柔性压力传感器中，压力传感器阵列中每个传感单元对小于1kPa的轻微载荷以及超过150kPa的载荷均有显著响应。这表明本发明的柔性压力传感器具有较宽的压力检测范围，在柔性电子、智能穿戴设备、医疗健康监测等领域具有广泛的应用前景。

一种可通过神经调控促进心肌梗死后心肌组织修复的预神经化细胞补片及其制备方法和应用

Absstract of: CN119925711A

本发明涉及一种可通过神经调控促进心肌梗死后心肌结构修复和心功能重建的预神经化细胞补片及其制备方法和应用，属于生物技术领域。所述可通过神经调控促进心肌梗死后心肌组织修复的预神经化细胞补片是由包含水凝胶基质、无机生物活性材料和神经相关细胞的生物墨水经过生物3D打印得到的三维支架结构细胞补片经过交联和预神经化培养得到的生物复合支架材料。本发明所述细胞补片是一种三维的生物复合支架材料，具有优异的神经活性，能够利用神经元高效地促进心肌梗死后的心肌组织修复及心脏功能重建。

一种适用于光固化增材制造的氧化锆陶瓷材料及制备修复体的方法

Absstract of: CN119925175A

本发明公开了一种适用于光固化增材制造的氧化锆陶瓷材料及制备修复体的方法，其原料由纳米氧化锆粉体和光敏树脂混合液组成，其中纳米氧化锆粉体的含量在79wt％以上；所述纳米氧化锆粉体的粒径在10‑400纳米。本发明烧结后能够制备出0.1mm厚度的超薄修复体以及至少3个单位的桥体不开裂，烧结后陶瓷件层间力学差异较小，修复体整体精度高，满足单个修复体整体误差≤120um的应用要求。

Printable dose formulation

Absstract of: FI20236217A1

The present disclosure concern printable dose formulations comprising an active pharmaceutical ingredient and excipients including one or more surfactants of hydrophilic-lipophilic balance (HLB) of at least 8. The disclosure also relates to a method for preparing medicament dosages using the printable dose formulations.

骨固定装置

Absstract of: CN118891012A

The present invention relates to a fixation device which is particularly suitable for engagement in a suitable bone site in the case of regenerative and/or reconstructive surgery, such as spinal surgery or trauma surgery.

一种具有促进细胞增殖能力的3D打印钛合金植入物及其制备方法和应用

Absstract of: CN119909227A

本发明公开了一种具有促进细胞增殖能力的3D打印钛合金植入物及其制备方法和应用，属于骨修复技术领域。本发明提供的水凝胶具有多孔结构，可以提供营养和氧气运输，利于细胞渗透和增殖，从而促进新组织的形成，为骨骼生长成多孔材料提供空间；提供的3D打印钛合金植入物凝胶涂层与3D打印钛合金间通过氨基和羟基间的氢键连接，结构紧凑，结合稳定性高；制备的水凝胶热具有良好的热稳定性、拉伸性、抗氧化性、抗菌性能和溶血性能，同时溶胀性小，降解性能优异，无细胞毒性，使3D打印钛合金植入物不会受身体温度的影响，适于骨修复。

一种氧化锆种植体表面促成骨和抗菌磷酸锌涂层的制备方法及装置

Absstract of: CN119912258A

本发明属于齿科种植体领域，尤其涉及一种氧化锆种植体表面促成骨和抗菌磷酸锌涂层的制备方法及装置，磷酸涂层的制备步骤包括：S4：取氧化锌、磷酸、硝酸和去离子水混合，并加入添加剂制备磷化液；S5：将磷化液和氧化锆种植体置于反应釜内，反应釜置于150～230℃的烘箱内加热3～12h，待自然冷却后取出；S6：采用去离子水超声清洗1～5min，并置于40～60℃的烘箱干燥，最后得到覆载磷酸锌涂层的氧化锆种植体；通过运用水热法在氧化锆牙种植体表面制备磷酸锌涂层，通过改变磷化液配方和调节水热反应的温度和时间，具备良好力学性能、细胞相容性、成骨性能和抗菌性能，对于拓展氧化锆陶瓷种植体材料在口腔领域的临床应用具有重要的意义。

屈曲可能なチタン合金インプラント

Absstract of: CN119451650A

An implantable device (2) includes a portion configured such that at least a majority of the portion, as measured by volume, comprises a Ti64 (Ti-6AI-4V) alloy. Additionally, the portion is bendable about a bending axis to a bending angle of at least about 50 degrees while maintaining structural integrity.

一种义齿数字化上瓷方法

Absstract of: CN119908866A

本发明涉及口腔修复技术领域，特别涉及一种义齿数字化上瓷方法。数字化上瓷的方法包括数字化扫描、数字化设计、数字化制造、高温烧结、数字化上瓷、烤瓷、自动抛光、质量检测。本发明通过采用数字化技术和自动化设备，实现义齿烤瓷冠上瓷过程的自动化，由自动上瓷机（上瓷机器人）进行（喷涂）上瓷操作，上瓷颜色计算机自动调制，保证了上瓷结果的颜色、形态等要求与设计一致，不再需要人工堆砌，并且减去了车瓷的流程，从而提高生产效率，降低人工劳动强度，提高制作精度和舒适度，产品质量精准可控；实现了义齿烤瓷冠上瓷过程的自动化，降低了人工劳动强度，提高了生产效率和制作精度。

一种使用前驱液光固化3D打印的立方体镂空结构及其应用

Nº publicación: CN119910896A 02/05/2025

Applicant:

西安交通大学

Absstract of: CN119910896A

本发明属于健康医疗技术领域，涉及一种使用前驱液光固化3D打印的立方体镂空结构及其应用，立方体镂空结构呈正六面体状，棱长为600～800微米、镂空度为25～35％，泊松比为0.425～0.525，立方体镂空结构设有贯穿的圆形气孔，圆形气孔的孔径为200～400微米；立方体镂空结构的成分包括：海藻酸钠SA、丙烯酰胺AM、丙烯酸甲酯ACMO；本发明立方体镂空结构增加了材料柔韧性和透气性，对脉搏跳动等微小形变更加敏感；内部结合保证了材料力学性能不受影响，经过多次循环工作后，仍保持信号输出的稳定性，没有明显的峰值衰减或初始电阻偏移，有效提升了传感器的长期监测能力和可靠性，解决了传统应变传感器依赖纳米填料提升灵敏度而导致抗疲劳性能不佳的问题。