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159
results.
Updated on
06/11/2025 [07:12:00]
Results 50 to 75 of 159
Absstract of: CN120837725A
本发明公开了一种3D打印的水凝胶支架及其制备方法，涉及水凝胶材料技术领域，本发明为了提升水凝胶材料的抗菌性与生物相容性，对其原料进行了改性处理；本发明首先使用了明胶作为原料，并对其进行处理，增加其表面氨基含量，便于后续步骤的反应；之后，本发明还使用2,5‑噻吩二羧酸为原料，通过控制反应条件，将其与2‑氨基苯并咪唑反应，从而生成了含有游离羧基、噻吩环与咪唑环结构的抗菌中间体；并通过酰胺键的方式将其结合在明胶链段中，之后在光引发剂作用下，酰胺键断裂生成酰基自由基，进一步的与丙烯酸酯双键发生偶联接枝，从而与形成水凝胶交联结构，为水凝胶材料提供足够的压缩强度。
Absstract of: WO2024180438A1
The present disclosure provides a method of making a ceramic article. The method includes (a) obtaining a photopolymerizable slurry or sol including a plurality of ceramic particles distributed in the photopolymerizable slurry or sol and (b) selectively polymerizing the photopolymerizable slurry or sol using actinic radiation and continuous movement of a build substrate through the photopolymerizable slurry or sol to form a gelled article. The method also includes (c) extracting solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a particular density. Further, additive manufactured ceramic articles are provided that exhibit a particular density, opacity, or both.
Absstract of: CN120837722A
本发明提供了一种宏观结构可调、多级有序的仿生凝胶及其制备方法，所述仿生凝胶按照如下方法制备：步骤1：聚乙烯醇基干粉的制备；步骤2：利用步骤1得到的聚乙烯醇基干粉进行3D打印；步骤3：循环冻融；步骤4：机械训练。通过控制循环冻融和机械训练的参数，使宏观结构逐渐复杂化的水凝胶内部纤维取向方向与宏观架构方向保持一致。本发明的打印凝胶的宏观结构为非单一方向，经过循环冻融、拉伸后打印凝胶的内部纤维取向也不是单一方向的，而是沿着非单一宏观架构方向，内部纤维取向于多个方向。
Absstract of: CN120837154A
本发明涉及骨缺损重建技术领域，具体涉及一种自体髂骨取骨重建骨缺损的3D打印导板及其制备方法和应用，所述自体髂骨取骨重建骨缺损的3D打印导板的制备方法包括以下步骤：基于患者肿瘤部位及骨盆的CT扫描DICOM数据，在计算机中模拟切除肿瘤并生成骨缺损区三维模型；根据所述骨缺损区模型，通过计算机辅助设计确定最佳髂骨取骨位置、大小、形状及取骨方案；依据所述取骨方案设计取骨导板及固定导板，所述导板通过3D打印技术制备。本发明将骨缺损重建的关键步骤(如肿瘤切除模拟、取骨方案设计、植骨固定模拟)均通过计算机辅助完成，形成标准化操作流程，构建了骨缺损重建的标准化解决方案。
Absstract of: CN120843428A
本发明提供了一种可磁控细胞培养基质的制备方法，其包括（1）将水凝胶溶液和磁粉混合，得到墨水；（2）对所述墨水进行除泡处理和充磁磁化，得到磁性墨水；（3）使用所述磁性墨水进行3D打印，得到具有期望形状的结构；（4）对所述结构进行固化和洗涤，然后将所述结构转移并固定在细胞培养材料中，得到可磁控细胞培养基质。本发明还提供了一种可磁控细胞培养基质及其用途。本发明的可磁控细胞培养基质生物相容性高、刺激参数可调，可应用于神经修复、组织工程等领域，显著提升细胞操控的精准性和效率。
Absstract of: CN120841943A
本发明涉及无机非金属材料技术领域，具体为一种纳米陶瓷熟浆，由以下重量份数组分组成：纳米氧化铝20‑25份、纳米氧化锆5‑20份、纳米二氧化硅10‑15份、改性纤维素醚3‑5份、硅烷偶联剂KH5602‑3份、复合分散剂1‑2份、去离子水30‑40份；还包括纳米羟基磷灰石0.5‑1份、磺化石墨烯oxide0.3‑0.6份；熟浆黏度5000‑8000mPa·s，粒径跨度≤0.8，Zeta电位绝对值≥40mV。本熟浆分散稳定，成型性好，固化后力学性能均衡，功能多样，生物相容性优，克服传统产品缺陷，应用前景广。
Absstract of: US2024227300A1
Methods and systems for generating support structures for additively manufactured objects are described herein. In some embodiments, a method includes receiving a digital representation of a dental appliance configured to implement a treatment stage of a treatment plan for a patient's teeth. The method can include generating a support structure arrangement configured to support the dental appliance during an additive manufacturing process. The support structure arrangement can be generated using a machine learning model. The machine learning model can be trained on a training data set including appliance data representing geometries of a plurality of dental appliances, support structure data representing geometries of a plurality of support structure arrangements, and outcome data representing outcomes of the additive manufacturing process for the plurality of dental appliances with the respective support structure arrangements.
Absstract of: CN120827636A
本申请提供的自供能生物3D打印生物墨水、3D打印生物活性支架及其制备方法，本发明是通过在不同分子量的有机高分子聚合物与促能量代谢物质混合制备得到可控释放的自供能生物3D打印生物墨水，该墨水生物相容性好，可通过改变供能物质含量，可以被设计成以可调和时间的方式“提供”和“接受”不同的细胞代谢调节线索，实现细胞更好的迁移和黏附，并发挥功能，同时该墨水在通过3D打印构建三维支架，具有可控缓释促能量代谢物质并生成微纳孔隙，提高支架亲水性，增强复合材料的生物能量代谢活性，促能量代谢物质可以为细胞生长提供足够的营养环境，调控细胞能量代谢过程，有利于细胞的粘附、生长与增殖及功能化。
Absstract of: CN120827641A
本发明为一种3D打印紫外光交联田菁胶水凝胶支架及制备方法和应用，所述田菁胶水凝胶为甲基丙烯酸酯化田菁胶水凝胶。所述制备方法包括以下步骤：甲基丙烯酸酐改性田菁胶水凝胶原料，经透析、冻干，获得甲基丙烯酸酯化田菁胶粉末；接着用含光引发剂的PBS进行溶解得到水凝胶；将所得水凝胶与干细胞复合，经过生物3D打印机打印后进行紫外光交联，即得所述田菁胶水凝胶支架产物。所述支架复合经软骨诱导液诱导的干细胞，有潜力应用于软骨修复工程。本发明具有生物相容性好、安全性强、材料性能可控、成本低、来源广、操作简单等优点。
Absstract of: CN120827646A
本发明涉及一种用于储药腔的载药微球原位附着方法和系统，其中，方法包括：步骤S1：在钛颌骨植入体内部设计药物储存流道，并对具有药物储存流道的钛颌骨植入体进行3D打印，得到试样，其中，所述药物储存流道为用于储药与释药的储药腔；步骤S2：对所述试样中储药腔的内壁进行雾化硅油处理与激光刻蚀；步骤S3：对雾化硅油处理与激光刻蚀后的试样进行微球的选型，并使用真空干燥法实现微球的原位附着；步骤S4：对微球原位附着进行测试，以判断微球的原位附着是否有效。本发明能够实现载药微球在储药腔的原位附着，并能有效控制药物的缓释、控释和延释。
Absstract of: CN120827451A
本申请实施例涉及医疗器械制造领域，公开了一种正畸托槽定位安装模组的制造方法以及根据该方法获得的正畸托槽定位安装模组。制造方法包括：模型设计步骤：使用计算机系统在数字化牙颌模型上的预定位置上添加托槽模型，形成数字化复合模型；原型打印步骤：将数字化复合模型导入打印设备，打印生成带托槽形状的原型实体；导板初定位步骤：将预制的定位导板覆盖在原型实体上，定位导板包括若干个子导板，每个子导板对应至少一颗牙齿；辅助层制作步骤：用液态硅胶填充定位导板和原型实体上托槽之间的空隙，形成辅助层，待液态硅胶固化后，取下带辅助层的定位导板；装配步骤：将托槽附件装入带辅助层的定位导板的凹槽中，形成带托槽的定位安装模板。
Absstract of: WO2025222183A1
Some embodiments relate to techniques of designing indirect bonding (IDB) trays that compensate for factors that affect the bonding success of orthodontic appliance(s) using IDB trays. The techniques apply optimization rules to an IDB tray design to optimize the transfer accuracy of orthodontic appliance(s) to a patient's teeth using IDB tray(s) of the IDB tray design. For example, the techniques may compensate for movement of teeth relative to an initial scan, narrow/wide central arches, teeth planned for extraction, and/or other factors. The techniques may, for example, customize segmentation of IDB trays in an IDB tray design to compensate for factors that affect bonding success.
Absstract of: US2025325385A1
A system for manufacturing a cranial remodeling orthosis (CRO) includes a scan device, a 3D printer, and processing circuitry. The scan device is configured to obtain scan data of a patient's head. The processing circuitry is configured to obtain the scan data of the patient's head. The processing circuitry is configured to use computer assisted design to generate a print file of the CRO based on the scan data, where the CRO includes at least one integrated closure mechanism. The 3D printer is configured to perform additive manufacturing to produce the CRO using the print file of the CRO.
Absstract of: US2025329015A1
This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.
Absstract of: US2025328030A1
Certain aspects provide a method for creating a discrete set of variants of a customizable wearable object, comprising: receiving a baseline 3D design file for a baseline 3D customizable wearable object; obtaining a fitting population comprising a set of 3D anatomy models representing potential wearers of the customizable wearable object; generating a plurality of modified 3D customizable wearable objects based on fitting the baseline 3D customizable wearable object to each 3D anatomy model of the set of 3D anatomy models; selecting one or more of the plurality of modified 3D customizable wearable objects as the discrete set of variants of the customizable wearable object; and generating a set of 3D design files corresponding to the discrete set of variants of the customizable wearable object.
Absstract of: US2025326927A1
This disclosure provides polymeric materials comprising polymer crystals, methods and resins for making the same, and objects and appliances made from said polymeric materials. Polymeric materials having polymer crystals provide favorable properties, such as enhanced durability and rigidity. This disclosure also provides polymeric materials comprising a crystalline phase comprising at least one polymer crystal, as well as an amorphous phase comprising at least one amorphous polymer. The crystalline phase can confer rigidity to the polymeric material, while the amorphous phase can confer elasticity and flexibility.
Absstract of: US2025326036A1
An in-process build structure includes a first build structure portion, a second build structure portion, and a cover. The second build structure portion is attached to the first build structure portion and defined by a plurality of porous portion struts. The cover at least partially overlies the second build structure portion and is attached to a remainder of the build structure by breakaway struts having breakaway strut diameters less than porous portion strut diameters of the porous portion struts. The in-process build structure is subjected to a surface treatment while the cover is attached to a remainder of the in-process build structure. The cover is removed from the remainder of the in-process build structure after the surface treatment.
Absstract of: WO2025219066A1
Provided are methods for preparing alginate microbeads that are particularly suitable as porogens for pore-forming hydrogel containing bioink formulations. Further provided are alginate microbeads obtainable by saidmethods, bioink formulations containing the same, and a method for producing a porous three-dimensional object using said bioink formulation.
Absstract of: US2025325284A1
The present disclosure describes a surgical guide comprising a cutting guide defining a plurality of cutting slots and including at least one removable insert positioned between the plurality of cutting slots. The at least one removable insert defines an aperture which is designed to receive a surgical fastening device. The surgical guide further comprises a template guide which defines a feature. The at least one removable insert is designed to fit in the template guide at least in part using the feature.
Absstract of: US2025325353A1
A method for manufacturing a mouth piece, in particular by jetting droplets of a first droplet material and a second droplet material in a 3D printing process. The method comprises a step of obtaining dental data of a user and an input mouth piece model. A simulation is carried out to determine a deformation of the input mouth piece model in response to an exerted force. Based on the deformation, the input mouth piece model is adapted to a work mouth piece model by substituting material of at least a portion of the input mouthpiece model by a replacement material. Finally, the mouth piece is manufactured based on the optimised work mouth piece model.
Absstract of: US2025325314A1
A cannulated bone fastener (10) for engagement into a target bone and/or target bone fragment is provided. According to one embodiment. the cannulated bone fastener (10) comprises an elongated shaft (11) extending between a bone fastener tip or tip section and a bone fastener head or head section. a central cannulation (17) having a cannulation entry with a first cross-sectional area (A1) at the shaft tip section, and a cannulation exit with a second cross-sectional area (A2) at the head section, and wherein the first cross-sectional area (A1) is different from the second cross-sectional area (A2), and wherein the surface roughness of the cannulation wall is at most 25 micrometres.
Absstract of: US2025325351A1
Some embodiments relate to techniques of designing indirect bonding (IDB) trays that compensate for factors that affect the bonding success of orthodontic appliance(s) using IDB trays. The techniques apply optimization rules to an IDB tray design to optimize the transfer accuracy of orthodontic appliance(s) to a patient's teeth using IDB tray(s) of the IDB tray design. For example, the techniques may compensate for movement of teeth relative to an initial scan, narrow/wide central arches, teeth planned for extraction, and/or other factors. The techniques may, for example, customize segmentation of IDB trays in an IDB tray design to compensate for factors that affect bonding success.
Absstract of: AU2024238878A1
A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.
Absstract of: WO2025219028A1
Method and apparatus for producing a mesostructural element and method for dental restoration in an oral cavity The invention relates to a method for producing a mesostructural element (3), the mesostructural element (3) being adapted to be fixed to at least one oral implant and to carry at least one suprastructure for prosthetic replacement of a plurality of teeth in an oral cavity, the method comprising: ˗ arranging at least one implant proxy element (17) at a predetermined position in a jawbone model (7), ˗ attaching at least one preform element (19) to the at least one implant proxy element (17), ˗ forming the mesostructural element (3) onto the at least one preform element (19) by laser metal deposition, wherein ˗ the jawbone model (7) and a LMD nozzle (11) are positioned relative to each other by a positioning apparatus (13) comprising at least four axes, and ˗ releasing the at least one preform element (19) from the at least one implant proxy element (17) and obtaining the mesostructural element (3).
Nº publicación: US2025325451A1 23/10/2025
Applicant:
KONDAKOV SERGEY EMILEVICH [RU]
OSIPOV ALEKSANDR PAVLOVICH [RU]
MELNIKOV MIKHAIL YAKOVLEVICH [RU]
MIKHAILOV DMITRY MIKHAILOVICH [RU]
MITROHIN MAXIM YURIEVICH [RU]
BELEZKII SERGEY OLEGOVICH [RU]
GORDEEV VLADIMIR VLADIMIROVICH [RU]
KONDAKOV Sergey Emilevich,
OSIPOV Aleksandr Pavlovich,
MELNIKOV Mikhail Yakovlevich,
MIKHAILOV Dmitry Mikhailovich,
MITROHIN Maxim Yurievich,
BELEZKII Sergey Olegovich,
GORDEEV Vladimir Vladimirovich
Absstract of: US2025325451A1
According to some embodiments, a method and system are provided comprising receiving a first quantity of at least one medicine in at least one cartridge of a plurality of cartridges of a printing device; receiving a porous media in the printing device; dispensing a first drop of the at least one medicine onto the porous media; and drying the dispensed drop on the porous media. Numerous other aspects are provided.
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