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175
results.
Updated on
14/07/2025 [07:17:00]
Results 50 to 75 of 175
Absstract of: WO2025141426A1
A method of decellularization of animal tissue, comprising the steps of: mechanical homogenization of animal-derived tissue, incubation of the homogenized tissue from step a) in a solution of trypsin and EDTA, subjecting the filtered tissue to incubation in a PBS buffer solution with a pH in the range of 7.2-7.6 containing a non-ionic detergent at a concentration of 4 - 2% and NH4OH at a concentration of 0.2 - 0.08%, rinsing the tissue with a PBS buffer solution containing an antimicrobial agent, incubation in a deoxyribonuclease solution at a concentration of 0.001 to 0.003% (w/v), rinsing the decellularized tissues obtained with a PBS buffer solution containing an antimicrobial agent, wherein the non-ionic detergent is a compound with a molecular weight of 596 g/mol and additional steps of incubating the tissue in the solution PBS buffer with a pH of 7.2- 7.6 containing a non-ionic detergent at a concentration of 1.5-0.5% and NH4OH ata concentration of 0.2-0.08%, where the incubation is carried out at a temperature below room temperature for 36-48h, and incubation of the tissue in a PBS buffer solution with a pH of 7.2-7.6 containing a non- ionic detergent at a concentration of 0.75-0.25% and NH4OH at a concentration of 0.2-0.08%, where the incubation is carried out at a temperature below room temperature for 36-48h. Bioink containing decellularized tissue of animal origin.
Absstract of: CN119698263A
A method of manufacturing a mouthpiece, in particular by ejecting droplets of a first drop of liquid material and a second drop of liquid material in a 3D printing process, the method comprising the steps of acquiring dental data of a user and inputting a model of the mouthpiece. A simulation is performed to determine a deformation of the input mouthpiece model as a function of the applied force. In accordance with the deformation, the input mouthpiece model is adapted to the working mouthpiece model by replacing at least a portion of the material of the input mouthpiece model with a replacement material. And finally, manufacturing the oral cavity part according to the optimized working oral cavity part model.
Absstract of: WO2025143784A1
The present disclosure relates to a photocurable shape-memory polymer composition for direct 3D printing, and an orthodontic device manufactured using same, and, more specifically, to a photocurable shape-memory polymer composition for direct 3D printing, and an orthodontic device manufactured using same, the composition exhibiting rigidity, stiffness and elasticity that are suitable for orthodontics in a first temperature range and exhibiting original shape restoration characteristics in a second temperature range that differs from the first temperature range.
Absstract of: WO2025143427A1
The present invention relates to a 3D printing integrated clean system that can maintain the cleanliness, temperature, and humidity of a 3D printer device, and at the same time, maintain the cleanliness, temperature, and humidity of pre-printing and post-printing zones or devices. The 3D printing integrated clean system comprises: a housing in which are defined a printer zone having a 3D printer or a 3D bio-printer installed therein and at least one operation zone, positioned on at least one side of the printer zone, for performing operations other than printing; a base movement stage which is installed in the housing and can move between the 3D printer zone and the at least one operation zone; an air supply unit which is installed at an upper end portion of the housing, and which provides clean air to the 3D printer zone and the at least one operation zone and controls the flow of the air; and a temperature and humidity control device, which is installed in a zone other than the lower surface of the housing, for controlling the temperature and humidity of the 3D printer zone and the at least one operation zone.
Absstract of: WO2025143324A1
A hearing assistance device and a manufacturing method thereof are provided. The hearing assistance device according to an aspect of the present invention is a hearing assistance device for assisting hearing, and the hearing assistance device may comprise: a sound processor for converting sound into a predetermined signal; a transmitter provided outside the body to transmit the signal to the outside; a receiver provided inside the body to receive the signal transmitted by the transmitter; and an electrode array including a plurality of electrode modules connected to each other in a ball-joint manner and inserted into the cochlea, and emitting a current corresponding to the signal received by the receiver.
Absstract of: WO2025144252A1
The invention relates to a magnetic substrate based tissue scaffold suitable for use in the growth, proliferation, and organization of cells in the technical field of tissue engineering, provided with intelligent behavior characteristics and thus dynamic structure, and a method for the production of this tissue scaffold with the support of a 3D printer.
Absstract of: US2025213355A1
Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.
Absstract of: US2025213327A1
A process for manufacturing a retainer, said process comprising the following steps: a) at an update time, after the end of an orthodontic treatment, acquiring at least one two-dimensional image of at least one portion of a dental arch of a user, called the “updated image”, by means of an image-acquiring apparatus; b) generating a digital three-dimensional model representing the dental arch of the user, called the “updated model”, based on the updated image; c) designing, based on the updated model and preferably by computer, a retainer suitable for keeping teeth in their configuration at the update time; d) manufacturing the retainer.
Absstract of: US2025213352A1
Methods for producing a custom-made stapes prosthesis for a patient and stapes prostheses so produced. The methods may include obtaining a three-dimensional image of a natural stapes bone of the patient; and forming a stapes prosthesis that closely approximates a three-dimensional shape of the natural stapes bone via an additive manufacturing technique based on the three-dimensional image. The stapes prosthesis comprises a suitable material that is not osteogenic and is not cytotoxic. The stapes prosthesis may include a plurality of pores having an average size of from about 5 to about 100 micrometers and may exhibit a frequency of sound transmission in a range of from about 2 to about 30 kilohertz.
Absstract of: US2025212852A1
An artificial structure for promoting microalgae growth includes a 3D-printed structure formed by positioning a printing surface on a movable stage of a 3D bioprinter in contact with a bio-ink that includes a mixture of a pre-polymer material with one or more of cellulose-derived nanocrystals (CNC), and microalgae cells. By projecting modulated light onto the printing surface while moving the stage, the bio-ink is progressively polymerized to define layers of an artificial coral structure with microalgae cells disposed thereon, where the artificial coral structure is configured to scatter light within the structure.
Absstract of: US2025215166A1
This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.
Absstract of: US2025215129A1
A photocurable composition, comprising a photopolymerizable component and a photopolymerization initiator, further comprising a filler wherein: in a case in which a square plate shaped test piece A1 with a length of 10 mm, a width of 10 mm, and a thickness of 2 mm is produced, at least one square surface B1 having an area of 3 μm on a side in at least one cross section of the test piece A1 has a sea-island structure composed of island portions comprising the filler and having a length of 0.1 μm or more, and a sea portion, an average surface elastic modulus of the island portions is 9.0 GPa or more, an average surface elastic modulus of the sea portion is 4.5 GPa or more, an area of the island portions is from 1.0% to 15.0% with respect to an entire area of the surface B1.
Absstract of: US2025214302A1
We describe an apparatus for producing a three-dimensional workpiece, the apparatus comprising: a process chamber for receiving a material from which the three-dimensional workpiece is producible using an additive layer manufacturing technique, wherein the process chamber comprises a translucent window; an irradiation device for irradiating, through the translucent window, the material for producing the three-dimensional workpiece; and an enclosure arranged between the translucent window of the process chamber and the irradiation device, wherein at least a part of the enclosure is translucent for an irradiation beam stemming from the irradiation device to travel from the irradiation device through the enclosure to the material for producing the three-dimensional workpiece, wherein the enclosure comprises an inlet and an outlet, and wherein the apparatus is configured to control a flow of a fluid through the enclosure via the inlet and the outlet.
Absstract of: US2025214047A1
Various devices and methods covering a technology for combinatorial liquid handling. At least some example embodiments of the devices may include a plurality of liquid dispensers configured to dispense drops, wherein at least a carrier drop is dispensed and sequentially collides and merges with drops dispensed from a sub-plurality of liquid dispensers, so that liquids from the sub-plurality of liquid dispensers are located in the carrier drop during flight, and a support surface being positioned so that the carrier drop lands on the support surface.
Absstract of: US2025213809A1
A system includes a container configured to contain a liquid. The system also includes a tubing apparatus having a first port configured for connection to a gas source, a second port configured for connection to a patient interface, and a third port configured for submersion within the liquid. The system also includes an actuator configured to move the third port vertically within the container. A method includes flowing gas into the first port of the tubing apparatus to the patient interface via the second port of the tubing apparatus. The method also includes moving the third port of the tubing apparatus vertically within the container such that an amount of the liquid in the container that is above the third port changes, thereby changing a pressure at the patient interface.
Absstract of: US2025213312A1
The present invention provides a 4D-printed humidity and magnetic dual responsive actuator with a bilayer structure, including a hydrogel film and a numerous of magnetic elastomer filaments, the numerous of magnetic elastomer filaments are printed on the hydrogel film to formed the bilayer structure, wherein the magnetic elastomer filaments are elastomer filaments embedded with magnetic particles, and the dual responsive actuator capable of responding to both humidity and magnetic fields, resulting in a reversible deformation that transforms into helix structures. The printed actuators can initially deform into helix structures in response to humidity stimuli and rapidly contract to a smaller size with the activation of a magnetic field. The shape deformation of this dual-responsive actuator is programmable and reversible, with stable and excellent repeatability.
Absstract of: US2025213353A1
Ossicular prostheses, and methods for producing such, are disclosed for treatment of middle ear damage caused by a malady of the middle ear such as cholesteatoma. The ossicular prostheses comprises a strut component attached to a disc via a rigid or flexible connecting joint. The strut is attachable to a head or footplate of a subject's stapes. The disc is attachable to the subject's existing tympanic membrane, or, alternatively, to an artificial tympanic membrane graft. In some embodiments, a scaffold is used to support the ossicular prosthesis and the tympanic membrane graft.
Absstract of: WO2025141425A1
A bioprinted liver model with a vascular system consisting of layers and comprising at least one flow channel in which: the first two layers forming the base of the model are 100% filled with bioink, and wherein layer 1 is positioned at an angle of 0° to the flow channel and layer 2 is positioned at an angle of 90° to the flow channel, the inner layers of the model are filled from 20% to 100% with bioink, wherein the inner layers comprise a centrally located at least one flow channel, the perimeter of which is printed with 100% filling and in which every inner layer is arranged at an angle of 60° with respect to the previous layer, the last two layers enclosing the model: the penultimate and the last layer are 100% filled with bioink and wherein the penultimate layer is arranged at an angle of 0° with respect to the flow channel and the last layer is arranged at an angle of 90° with respect to the flow channel, wherein the bioink used is based on natural polymers, synthetic polymers, methacrylated derivatives of natural polymers or mixtures thereof. A method for manufacturing the liver model and the use thereof.
Absstract of: AU2025203195A1
0001 A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patient's nares and/or an entrance to the patient's mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patient's respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three dimensional shape that has multiple curvatures.
Absstract of: EP4578633A2
The invention relates to a method for partial curing of an initial photoreactive material for 3D printing, comprising the steps of:a) providing an item (1) comprising the initial photoreactive material for 3D printing,b) a partial irradiation step comprising irradiating at least one curing section (20) of the initial photoreactive material for 3D printing of the item with a curing irradiation, yielding at least one cured section (120) of a partially-cured item (10), and at least one semi-curing section (40) of the initial photoreactive material of the item is irradiated with a semi-curing irradiation, yielding at least one semi-cured section (140) of the partially-cured item.
Absstract of: AU2023330160A1
The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof,
Absstract of: TW202416928A
A drug delivery system includes a container comprising a luer compartment and a fluid compartment, a luer fitting arranged within the luer compartment and in fluidic communication with the fluid compartment, and a dispenser in fluidic communication with the fluid compartment. A method of aseptically transferring a drug to such a drug delivery system may include providing a vial comprising the drug to be transferred, withdrawing a volume of the drug from the vial with a syringe, coupling the syringe to a drug delivery system via the luer fitting, transferring the drug from the syringe to the drug delivery system, and decoupling the syringe from the drug delivery system.
Absstract of: TW202416928A
A drug delivery system includes a container comprising a luer compartment and a fluid compartment, a luer fitting arranged within the luer compartment and in fluidic communication with the fluid compartment, and a dispenser in fluidic communication with the fluid compartment. A method of aseptically transferring a drug to such a drug delivery system may include providing a vial comprising the drug to be transferred, withdrawing a volume of the drug from the vial with a syringe, coupling the syringe to a drug delivery system via the luer fitting, transferring the drug from the syringe to the drug delivery system, and decoupling the syringe from the drug delivery system.
Absstract of: WO2024044071A1
Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.
Nº publicación: EP4577174A1 02/07/2025
Applicant:
MOBBS ROSEMARY [AU]
Mobbs, Rosemary
Absstract of: AU2023327795A1
A teat product having a base portion and a nipple portion extending from the base portion, the teat product having a pliable region, wherein said pliable region of the teat product is configured to be deformable in shape in response to force applied by a mouth of a feeding infant.
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