Alerta

ADDITIVE MANUFACTURING METHOD AND APPARATUS FOR INDIVIDUALIZED POLYPILL CAPSULES USING MICRO-DOSED AND COMPACTED POWDERS

Absstract of: AU2024221303A1

A method and apparatus enabling additive manufacturing of individualized oral therapeutic capsule forms containing multiple medicinal ingredients, also referred to as a personalized polypill process. A process and supporting apparatus to fulfil the formulated therapy prescribed by a physician to address the medical conditions of an individual patient, furthering the practice of personalized medicine. The methods and apparatus apply to the powder forms of active pharmaceuticals, dietary supplements, and specialized chemicals, such as diagnostic inks and dyes. The methods teach the deposition of computer-controlled amounts of high-potency powder forms of active ingredients deposited in sequential layers into a single delivery form. Each active ingredient layer is sequentially deposited to a programmable dosage accurately controlled with closed-loop gravimetric sensing, enabling sub-milligram mass deposition accuracy. Cumulative doses are compacted into segregated layers of programmable density with the optional addition of an inert barrier film between each chemical entity to minimize interactions.

FOOTBALL HELMET WITH COMPONENTS ADDITIVELY MANUFACTURED TO MANAGE IMPACT FORCES

Absstract of: US2025256194A1

The invention relates to a multi-step method with a number of processes and sub-processes that interact to allow for the selection, design and/or manufacture of a protective sports helmet for a specific player, or a recreational sports helmet for a specific person wearing the helmet. Once the desired protective sports helmet or recreational sports helmet is selected, information is collected from the individual player or wearer regarding the shape of his/her head and information about the impacts he/she has received while participating in the sport or activity. The collected information is processed to develop a bespoke energy attenuation assembly for use in the protective helmet. The energy attenuation assembly includes at least one energy attenuation member with a unique structural makeup and/or chemical composition. The energy attenuation assembly is purposely engineered to improve comfort and fit, as well as how the helmet responds when an impact or series of impacts are received by the helmet.

ADDITIVE MANUFACTURING TECHNIQUES FOR A SOCKET AND LINER COMBINATION DEVICE

Absstract of: US2025255737A1

A prosthetic assembly includes a socket and a liner. The socket includes a first interlocking feature and defines an inner volume. The liner includes a second interlocking feature. The first interlocking feature and the second interlocking feature are configured to engage each other when the liner is inserted into the inner volume of the socket. The liner is configured to receive a distal limb of a patient. At least one of the socket or the liner include inner voids extending within walls of the socket or the liner.

PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS

Absstract of: US2025255781A1

This invention relates to methods of producing 3-D printed pharmaceutical products.

METHODS, SYSTEMS, AND APPARATUSES FOR GUIDING TRANSDUCER ARRAY PLACEMENT

Absstract of: US2025258479A1

Methods, systems, and apparatuses are described for guiding placement of transducer arrays on a patient.

IMPROVED NANOCARRIER MANUFACTURING

Absstract of: US2025256248A1

An apparatus may be for producing nanocarriers and/or nanoformulations. A process may be for producing a nanocarrier and/or a nanoformulation with this apparatus. According to the preparation, a first liquid phase and a second liquid phase are mixed first to give a primary mixture using a static mixer. In a subsequence mixing step the primary mixture is diluted with a third liquid. An aspect of apparatus may be that the arrangement of the static mixer inside a linear pipe conducting a third liquid phase. Thus, the primary mixture exiting the mixer is instantaneously diluted with to give secondary mixture. The volume flow of the third mixture is chosen larger than the volume flow of the primary mixture. By these measures, nanocarriers with improved morphology and homogeneity are produced. Encapsulation efficiency was enhanced as well.

MEW TISSUE SCAFFOLD

Absstract of: AU2023365980A1

A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.

METHOD OF MANUFACTURING A CUSTOMIZED SADDLE CUSHION

Absstract of: EP4599762A1

A method (10) of manufacturing a customized saddle cushion (30), such as a bicycle saddle cushion, the method comprises applying a molding paste (14) onto a saddle shell (16) to form a probe saddle (18); letting the molding paste of the probe saddle deform under a weight and motion of a rider (12) riding the bicycle during a riding session; obtaining a 2-D pressure map (22) on the geometrically stable deformed molding paste ; obtaining a 3-D saddle cushion model (21) of the geometrically stable deformed molding paste; and associating the 3-D saddle cushion model with the 2-D pressure map to obtain a 3-D saddle cushion pressure mesh (24) to be used as a reference for 3-D printing the customized saddle cushion. A density of the 3-D saddle cushion pressure mesh is correlated to the 2-D pressure map.

DEVICE FOR PRODUCING THREE-DIMENSIONAL SCREEN PRINTING WORKPIECES

Absstract of: EP4599816A1

Vorrichtung zur Herstellung von dreidimensionalen Siebdruckwerkstücken, insbesondere 3D-Siebdruckanlage, mit einer ein Drucksieb aufweisenden Druckeinrichtung für die schichtweise Erzeugung zumindest eines Siebdruckwerkstücks in mehreren Druckvorgängen und mit einer Dosiereinrichtung zur dosierten Ausgabe einer pastösen Druckmasse auf das Drucksieb, wobei die Dosiereinrichtung wenigstens einen Behälter zur Aufbewahrung der pastösen Druckmasse, eine Ausgabevorrichtung zur Ausgabe der Druckmasse auf das Drucksieb und eine zwischen dem Behälter und der Ausgabevorrichtung verlaufende Zuführleitung zur Zuführung der Druckmasse aus dem Behälter bis zur Ausgabevorrichtung aufweist.

METHODS AND ADAPTERS FOR MIXING PHARMACEUTICAL COMPLEXES

Absstract of: WO2024076590A2

Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.

DEVICE FOR PRODUCING THREE-DIMENSIONAL SCREEN PRINTING WORKPIECES

Absstract of: EP4600019A1

Vorrichtung zur Herstellung von dreidimensionalen Siebdruckwerkstücken, insbesondere 3D-Siebdruckanlage, mit einem Drucksieb und mit einer Rakelvorrichtung zum Fluten des Drucksiebs mit einer Druckmasse und/oder zum Pressen von Druckmasse durch das Drucksieb, wobei die Rakelvorrichtung wenigstens ein Rakelwerkzeug, eine Sensoreinrichtung zur Erfassung von auf das Rakelwerkzeug wirkenden Rakelkräften sowie eine Steuereinrichtung zur Auswertung und/oder Speicherung von Sensordaten der Sensoreinrichtung aufweist, wobei die Steuereinrichtung dazu ausgebildet ist, mittels der Sensoreinrichtung und/oder aus erfassten und/oder abgespeicherten Sensordaten der Sensoreinrichtung eine Siebrückstellkraft und/oder Siebspannung des Drucksiebs zu ermitteln

- 3D Ceramic-Resin Composites with Antimicrobial Effect and 3D Printing Technique

Absstract of: KR20250122164A

본 발명은 항균 기능성 소재인 산화아연에 실리카가 복합화된 산화아연/실리카 분말을 광경화가 가능한 아크릴 기반의 세라믹-레진에 복합화 하는 제조방법 및 이를 3D 프린팅 기술과 결합한 기술로서 궁극적으로 항균 특성을 나타내는 조성물을 이용한 치과용 임시치 구조물 제조 기술에 관한 것이다.

ELECTRICAL POWER OUTPUT CONTROL BASED ON MECHANICAL FORCES

Absstract of: EP4599783A2

A surgical instrument comprising a jaw assembly is disclosed. The surgical instrument further comprises a motor-driven drive system configured to manipulate the jaw assembly. The surgical instrument also comprises a control system configured to control the drive system and, also, control a power supply system configured to supply electrical power to electrodes defined in the jaw assembly. In use, the surgical instrument can be used to apply mechanical energy and electrical energy to the tissue of a patient at the same time, or at different times. In certain embodiments, the user controls when the mechanical and electrical energies are applied. In some embodiments, the control system controls when the mechanical and electrical energies are applied.

印刷物を作成するシステムおよび方法

Absstract of: JP2023118129A

To provide a system and method for forming a product with different size particles.SOLUTION: A system for forming a product with different size particles includes at least one print head region and at least one processor. The at least one print head region is configured to retain: a first group of print heads 106 configurable to additively print at least a first portion of a product with a first material having a first average particle size; and a second group of print heads 106 configurable to additively print at least a second portion of the product with a second material having a second average particle size. The at least one processor is configured to receive information reflective of desired properties of the product and regulate the first group of print heads 106 and the second group of print heads 106 to unevenly distribute the first material and the second material in a layer-by-layer basis to impart differing structural characteristics to differing portions of the product based on the information reflective of the desired properties of the product.SELECTED DRAWING: Figure 1

光造形用樹脂組成物

Absstract of: US2023096105A1

The present invention provides a resin composition for stereolithography that is easily shapable with good shape precision while reducing sedimentation of inorganic particles during storage, and a obtained three-dimensional shaped article thereby excels in mechanical characteristics such as flexural strength and flexural modulus, in addition to having a desirable shade and good shade stability. The present invention relates to a resin composition for stereolithography comprising a polymerizable monomer (a), a photopolymerization initiator (b), an inorganic particle (c) having an average particle diameter of 5 to 500 nm, and a hindered phenolic compound (d), wherein the content of the photopolymerization initiator (b) is 0.1 to 10 parts by mass relative to 100 parts by mass of the polymerizable monomer (a), the content of the inorganic particle (c) is 50 to 400 parts by mass relative to 100 parts by mass of the polymerizable monomer (a), and the content of the hindered phenolic compound (d) is 0.1 to 500 parts by mass relative to 100 parts by mass of the photopolymerization initiator (b).

SYSTEM FOR APPLYING AT LEAST TWO KINDS OF LIQUID ONTO RESPECTIVE TARGETED AREAS OF A SUBSTRATE AND METHOD THEREFOR

Absstract of: US2020015573A1

The present invention relates to a system (1) for applying at least two kinds of liquid onto respective targeted areas of a substrate (S). The system (1) includes first and second storage unit (10a, 10b) that accommodate first and second liquids (F1, F2); a pressured gas supply unit (20) that is fluidly connected to the first and second storage unit (10a, 10b); first and second applicator (30a, 30b) that are fluidly connected to the first and second storage unit (10a, 10b); and a controller (40) that is operatively connected to the applicator (30a, 30b). The pressured gas supply unit (20) causes pressure of a pressured gas to act on the liquids (F1, F2) within the storage unit (10a, 10b). The first and second applicator (30a, 30b) each include at least one nozzle (300a, 300b) disposed so as to face the substrate (S). The first and second applicator (30a, 30b) spray the first and second liquids (F1, F2) within the first and second storage unit (10a, 10b) from the nozzles (300a, 300b) toward the substrate (S) by the action of the pressured gas from the pressured gas supply unit (20). The controller (40) individually controls the first and second applicator (30a, 30b) so that the first applicator (30a) sprays the first liquid (F1) toward a targeted area for the first liquid (F1) on the substrate (S) and the second applicator (30b) sprays the second liquid (F2) toward a targeted area for the second liquid (F2) on the substrate (S). The present invention also relates to a method f

ORTHODONTIC TEETH-STRAIGHTENING MEANS MADE OF SHAPE-MEMORY POLYMERS, AND METHOD FOR THE PRODUCTION OF SAME

Absstract of: US2025228647A1

An orthodontic teeth-straightener, comprising a splint element which contains, or is entirely made from, a thermoplastic polyurethane having shape-memory properties. The thermoplastic polyurethane having shape-memory properties is selected from the group of polyether polyurethanes and contains hard segments which contain polyurethane units that have been obtained by polyaddition of the isocyanate groups of a diisocyanate to the hydroxyl groups of a diol acting as a chain extender, thereby forming urethane groups. The polyether polyurethane also contains soft segments, which contain, or are entirely made from, polyether units in the form of polyalkylene glycols, wherein the polyether units are bonded to isocyanate end groups of the diisocyanate of the hard segments, thereby forming urethane groups with the hard segments. The thermoplastic polyether polyurethane is both thermo-responsive and water-responsive and thus gives the splint element dual-stimuli responsive shape-memory properties.

Acellular matrix woven material, preparation method and application thereof

Absstract of: US12383654B1

An acellular matrix woven material, a preparation method and an application thereof are provided. The acellular matrix woven material is prepared by combining 3D printing with weaving. At the same time, also provided are the acellular matrix woven material prepared by the preparation method and its application in preparing tissue engineering scaffold materials.

一种唇颊侧固位骨膜下种植体支架及制作方法

Absstract of: CN120458756A

本发明公开了一种唇颊侧固位骨膜下种植体支架及制作方法，种植体支架包括唇颊侧连接板，唇颊侧连接板上一侧设有螺钉孔，螺钉孔内设有固定于唇颊侧的螺钉，唇颊侧连接板上另一侧为弯钩结构，弯钩结构的凸起位置设有多个种植基台；唇颊侧连接板通过扫描数据重建患者完整颌骨结构，提取唇颊侧骨面轮廓，在三维模型中设计唇颊侧连接板的轮廓线后得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇颊侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明在保证刚度和耐用性的同时，整体结构更加轻便，使用的螺钉数量更少，显著提高支架的使用寿命，减少压力性损伤的风险。

一种挤出和喷墨复合的3D打印方法

Absstract of: CN120461813A

本发明公开了一种挤出和喷墨复合的3D打印方法。本发明通过挤出‑喷墨复合3D打印技术，以单液滴作为基本沉积单元，逐层堆积融合形成二维/三维高精度复杂结构。本发明实现了多种其他方法难以实现的高精度复杂结构打印，打印的二维复杂结构最小特征尺寸约50μm，三维复杂结构最小特征尺寸约80μm，并通过载细胞打印实现了体外跨尺度分级二维/三维血管网络的构建；且本发明所提供的方法可以实现高精度复杂三维结构的单步成型，避免了工艺切换带来的重复定位误差和二次加工，为解决复杂异质体外组织模型和复杂精细三维结构的制造难题提供了一种便捷有效的制造技术思路。

一种双层夜磨牙口垫及其制备方法

Absstract of: CN120458813A

本发明提供了一种双层夜磨牙口垫及其制备方法，属于医疗器械领域。本发明提供了一种双层夜磨牙口垫，由中空的GC软衬层和中空的PEEK硬质层组成，所述GC软衬层的外表面与PEEK硬质层的内表面相接触。本发明双层夜磨牙口垫的内层采用柔性生物相容材料—GC软衬层贴合牙列及软组织，极大减轻压迫感和异物感，适宜长时间佩戴，显著提升患者依从性；外层选用高强度、耐磨的PEEK，具备优异的抗咬合磨损能力和结构稳定性，特别适用于中重度夜磨牙患者的长期使用。

一种腭侧固位骨膜下种植体支架及制作方法

Absstract of: CN120458755A

本发明公开了一种腭侧固位骨膜下种植体支架及制作方法，种植体支架包括腭侧连接板，腭侧连接板上一侧设有螺钉孔，螺钉孔内设有固定于腭侧的螺钉，腭侧连接板上另一侧设有多个种植基台；唇颊侧连接板通过扫描数据重建患者完整颌骨结构，提取唇颊侧骨面轮廓，在三维模型中设计唇颊侧连接板的轮廓线后得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇颊侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明兼具良好的力学稳定性与生物适应性，腭侧进路微创隐蔽，尤为适用于美学区及复杂骨缺损病例的修复需求。

一种基于仿生学原理的3D打印全踝关节假体

Absstract of: CN120458785A

本发明涉及医疗器械技术领域，具体地说是一种基于仿生学原理的3D打印全踝关节假体。包括仿生脚、仿生小腿和仿生大腿，所述仿生小腿活动安装在仿生脚的外侧表面，所述仿生小腿和仿生大腿的外侧表面设置有散热机构，所述仿生大腿通过散热机构与仿生小腿构成活动连接，所述仿生大腿的内腔中设置有自适应贴合机构。本申请可以通过双面齿框啮合连接的带轴齿轮转动，带动与带轴齿轮啮合连接的半面卡尺向内滑动，通过拉杆拉动弧夹板向内进行夹持，压杆会压动第二气囊通过第二伸缩软管向弧气囊的内部进行充气，能够贴合不同大小和形状的肢体，弹力尼龙套保证了贴合时的舒适性和透气性。

一种具有电磁响应骨修复多孔组织工程支架及其制备方法和应用

Absstract of: CN120459383A

本发明公开了一种具有电磁响应骨修复多孔组织工程支架及其制备方法和应用，属于医用材料领域。本发明通过将超顺磁性纳米颗粒均匀嵌入到高分子仿生多孔支架，结合3D打印技术，构建兼具宏观力学强度与微观生物活性的分级多孔支架。利用多孔结构模拟骨细胞外基质，优化骨整合效率。同时结合支架的电磁响应特性，通过外加电磁场动态调控，诱导间充质干细胞的成骨分化并加速血管生成，通过跨学科技术融合，为临床难治性骨缺损提供一种兼具力学适配性、生物活性及智能响应性的新一代修复支架，从而实现“材料‑细胞‑微环境”三重协同修复机制。

마이크로매니퓰레이터로서 사용하기 위한 도구 및 도구를 제조하기 위한 방법

Nº publicación: KR20250120982A 11/08/2025

Applicant:

쓰리디마이크로프린트게엠베하

Absstract of: WO2024120583A1

The invention relates to a tool for use as a micromanipulator and to a method for producing the tool. The tool consists of a plurality of parts in the form of - a frame (1) which is oriented along a longitudinal axis (L) and which is arranged as a hollow body around an interior, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuation element (3) which is arranged on a second end face (1.2) opposite the first end face (1.1) and which is mounted slidably and axially movably in the interior of the frame (1), said parts being connected interlockingly and movably to one another by means of necessary connecting and bearing elements, and the tool being entirely generated by additive manufacture, including all the necessary gaps between the parts movably connected to one another. According to the method, the tool with all its parts and with the gaps between the movable parts is manufactured entirely by additive manufacture in one processing operation.