Absstract of: WO2022236103A1
Embodiments of the present disclosure include methods of simultaneously manufacturing two or more hydrogel constructs (e.g., tubular hydrogel constructs). In some embodiments, the method comprises one or more of the following steps: providing a vat comprising a bio-ink composition containing one or more monomers and/or one or more polymers; applying electromagnetic radiation from an electromagnetic radiation source to cure a layer of the hydrogel constructs (e.g., tubular hydrogel constructs); and applying electromagnetic radiation from the electromagnetic radiation source one or more additional times to produce one or more additional layers of the hydrogel constructs (e.g., tubular hydrogel constructs).
Absstract of: EP4834272A1
Disclosed in the present disclosure are a method and apparatus for obtaining a tooth model, a storage medium, and an electronic device. The method comprises: acquiring first tooth model data of a first tooth of a patient, wherein the first tooth comprises at least one accessory; predicting, on the basis of a neural network model, the first tooth model data to obtain predicted point cloud data, wherein the predicted point cloud data is tooth model data which is predicted on the basis of the neural network model and does not comprise data of a first accessory, and the first accessory is an accessory on the first tooth; determining, according to the predicted point cloud data, a first region of the first tooth model data, wherein the first region comprises an area corresponding to the first accessory; and generating, according to the first region, the first tooth model data, and the predicted point cloud data, second tooth model data, wherein the second tooth model data is configured for indicating the first tooth with the first accessory removed.
Absstract of: EP4834419A2
0001 The invention relates to an Implantable neuro-modulator device, comprising a hermetically sealed housing, wherein an antenna for communicating with external devices and/or for wirelessly receiving electrical energy is positioned within the housing, wherein a major part of the housing is electromagnetically transparent to radiation in the frequency range below 20 MHz, in particular between 5 and 15 MHz.
Absstract of: WO2018175897A1
Stemless components and fracture stems for joint arthroplasty, such as shoulder arthroplasty, are disclosed. Also, methods and devices are disclosed for the optimization of shoulder arthroplasty component design through the use of medical imaging data, such as computed tomography scan data.
Absstract of: WO2018071639A1
The present invention relates to bioinks based on undenatured collagen, kits containing the same, and methods of printing three-dimensional structures using the bioinks.
Absstract of: EP4834963A1
The present disclosure relates to a photocurable shape-restoring polymeric composition for direct three-dimensional (3D) printing and an orthodontic appliance manufactured therefrom. More particularly, the present disclosure relates to a photocurable shape-restoring polymeric composition that exhibits stiffness, rigidity, and elasticity suitable for orthodontic treatment within a first temperature range and exhibits shape-restoration properties within a second temperature range different from the first temperature range, and to an orthodontic appliance manufactured using the photocurable shape-restoring polymeric composition.The photocurable shape-restoring polymeric composition comprises a photocurable compound and a photoinitiator and is suitable for directly manufacturing orthodontic appliances by three-dimensional (3D) printing.
Absstract of: US20220168514A1
0001 The present disclosure provides an aerosol delivery device and a liquid delivery and atomization assembly for use with an aerosol delivery device. In one implementation, the liquid delivery and atomization assembly comprises a liquid composition, an atomization assembly, and a liquid delivery component configured to transport at least a portion of the liquid composition to the atomization assembly. The liquid delivery component comprises at least one microchannel configured to deliver the portion of the liquid composition to the atomization assembly, and the microchannel includes a variable flow characteristic defined along at least a portion of the microchannel, the variable flow characteristic being configured to control the flow of the portion of liquid composition through the microchannel.
Absstract of: EP4834209A2
0001 Methods, systems, and devices for activity classification are described. A system may receive physiological data associated with a user via a wearable device, where the physiological data includes at least motion data. The system may identify an activity segment during which the user is engaged in a physical activity based on the motion data, where the activity segment is associated with activity segment data including at least the physiological data collected during the activity segment. The system may generate activity classification data associated with the activity segment based on the activity segment data, the activity classification data including a set of classified activity types and corresponding confidence values. The system may then cause a graphical user interface (GUI) of a user device to display the activity segment data and at least one classified activity type of the set of classified activity types.
Absstract of: EP4834420A2
This document describes a number of inventions comprising of one or more wearable devices (i.e. attached or applied to limbs, body, head or other body extremities but also applicable to implanted or physiologically attachable systems). These systems have a means of enabling diagnostic or prognostic monitoring applicable to monitoring relevant parameters and corresponding analysis determination and characterisation applicable to the onset or detection of events or health conditions of interest. One application relates to sleep monitoring and associate EEG sensors.
Absstract of: WO2025072555A1
The present disclosure relates to a method and system for acquiring and analyzing physiological signals of a subject to detect risk or occurrence of stroke or brain infarction. A wearable wireless device together with one or more clusters of electrodes can be used to record the physiological signals during the sleep-wake cycle. The physiological signals may be utilized to perform sleep and wake analysis. In some instances, the physiological signals corresponding to each hemisphere of the brain may be compared, for example, using coherence, to quantify asymmetry across hemispheres and to identify possible strokes, silent brain infarcts (SBIs), or aneurysms. Biomarkers may be extracted based on sleep and wake analysis and coherence. The biomarkers may include an indication of obstructive sleep apnea or apnea risk, a reduced duration of slow wave sleep, or a presence of SBIs, or aneurysms. A prediction model may be used to generate a stroke risk score based on the biomarkers for early detection of potential individuals at risk of stroke.
Absstract of: WO2025071725A1
A computing device obtains a stack of ultrasound images of a target anatomical structure. The computing device, while obtaining the stack of images, generates from the stack of ultrasound images a composite image that satisfies a first set of conditions for providing diagnostic information of the target anatomical structure. In response to generating the composite image that satisfies the first set of conditions, the computing device causes display of the composite image on a display device.
Absstract of: WO2024248394A1
The present invention relates to a continuous production method of a transparent orthodontic device and a transparent orthodontic device manufactured by the continuous production method, and has a purpose to manufacture a patient-customized transparent orthodontic device by using 3D data on an oral structure of a patient. By the present invention, the orthodontic device may be manufactured by 3D printing, and washing, supporter separation, post-curing, and heat treatment processing may be performed as continuous processes, so as to increase production efficiency and enable selection of defective products without using separate equipment. In addition, when the orthodontic device is manufactured by 3D printing, an output time can be shortened and curing efficiency can be increased, and when the orthodontic device is output, a barcode enabling recognition of unique information of the patient is output as well, so that a plurality of orthodontic devices can be continuously produced.
Absstract of: EP4834397A2
0001 Proposed devices operate on positive pressure with as little as 5-6 ml of air and can efficiently empty (emitted doses >80%) and deliver the aerosol to infant lungs (lung delivery efficiency of ~60% of the loaded dose). Significant features include internal flow structure of the air-jet DPI, automatic gas sources, infant-specific interfaces, small diameter nasopharyngeal tubes, sealed nasal prongs, 3D rod array preceding patient interface, nasal CPAP rapid aerosol delivery system, nasal CPAP streamlined interface, multidose storage and delivery unit, and pressure sensing near the infant airways (at the nasal cannula interface).
Absstract of: US20230001123A1
0000 A respiratory pressure therapy system for providing continuous positive air pressure to a patient via a patient interface configured to engage with at least one airway of the patient. The system includes: a flow generator configured to generate supply of breathable gas for delivery to the patient via the patient interface; at least one sensor; a display; and a computing device. The computing device is configured to: receive sensor data that is based on measured physical property of the supply of breathable gas; control, based on the received sensor data, the flow generator to adjust a property of the supply of breathable gas; receive, an input indicating assistance is needed with using the patient interface; receive one or more images of the patient with the patient interface; analyse the received one or more images; and based on the analysis, display instructions for positioning the patient interface.
Absstract of: WO2021092071A1
The disclosure provides population and non-population-based classifiers to categorize patients and cancers. The population-based classifiers disclosed integrate signatures, i.e., global scores related to the expression of genes in particular gene panels. The non-population-based classifiers are generated using machine-learning techniques (e.g., regression, random forests, or ANN). Each type of classifier stratifies patients and cancers according to tumor microenvironments (TME) as biomarker-positive or biomarker-negative, and treatment decisions are then guided by the presence/absence of a particular TME. Also provided are methods for treating a subject, e.g., a human subject, afflicted with cancer comprising administering a particular therapy depending on the classification of the cancer's TME according to the disclosed classifiers. Also provided are personalized treatments that can be administered to a subject having a cancer classified into a particular TME, and gene panels that can be used for identifying a human subject afflicted with a cancer suitable for treatment with a particular therapeutic agent.
Absstract of: EP4834402A2
A cushion assembly to deliver a flow of air to a patient for treatment of sleep disordered breathing, the cushion assembly comprising: a plenum chamber at least partially forming a cavity pressurizable to a therapeutic pressure above ambient air pressure, the plenum chamber including at least one plenum chamber inlet port sized and structured to receive the flow of air at the therapeutic pressure for breathing by the patient in use; and a seal-forming structure having a sealing portion constructed and arranged to form a pressure-assisted seal with a region of the patient's face surrounding an entrance to the patient's airways, the sealing portion having at least one hole formed therein such that the flow of air at the therapeutic pressure is delivered to at least an entrance of the patient's nares, wherein the seal-forming structure includes a support structure connecting the sealing portion to the plenum chamber, the support structure including a stem projecting from the plenum chamber, wherein the seal-forming structure includes a seal biasing portion extending around a perimeter of the cushion assembly, the seal biasing portion being less rigid than adjacent portions of the support structure, and wherein the seal biasing portion is configured to support the sealing portion as a gimbal or ball joint allowing movement and flexibility of the sealing portion relative to the plenum chamber along multiple directions when the cavity is pressurized during use.
Absstract of: US12779115B1
Methods and systems for multi-compound and custom dosing using an intelligent injection device platform are disclosed. A device may receive patient profile data. A device may analyze the patient profile data using an artificial intelligence module to determine an optimal compound combination. A device may calculate customized ratios of compounds based on an individual patient characteristic. A device may program a formulation system to create a personalized mixture from multiple preloaded chambers containing different compounds. A device may verify patient identity using a verification system before initiating personalized formulation. A device may control multiple chamber valves to combine selected compounds. A device may monitor temperature conditions of each chamber independently using temperature sensors to ensure compound stability. A device may deliver the personalized formulation while transmitting administration data including formulation details and patient profile correlations.
Absstract of: CN123025376A
一种多功能生物活性支架制造装置,包括:支架打印模块,支架后处理模块,支架赋能模块,支架装配模块,控制模块和运输模块;所述控制模块控制支架打印模块,支架后处理模块,支架赋能模块,支架装配模块和运输模块的运作;支架打印模块为第一工序;支架后处理模块位于支架打印模块后面为第二工序;支架赋能模块位于支架后处理模块后面为第三工序;支架装配模块位于支架赋能模块后面为第四工序;所述运输模块与支架打印模块,支架后处理模块,支架赋能模块,支架装配模块相邻按工序顺序运输支架。本发明半自动化地实现了多功能生物活性支架按需个性化制造,可应用于大批量生产。
Absstract of: CN123023987A
本发明公开了一种用于齿科3D打印树脂的增韧增强惰性玻璃填料,该玻璃填料按重量百分比包括SiO2 55‑68%,Al2O3 8‑15%,B2O3 5‑12%,BaO 8‑18%,ZrO2 2‑8%,Na2O 1‑4%,平均粒径为0.5‑3μm,表面经硅烷偶联剂处理。制备方法包括按配比称取原料混合后于1350‑1480℃熔融,水淬急冷,球磨粉碎,硅烷偶联剂表面改性。该填料具有良好的分散性和界面相容性,能够同时提高树脂的强度和韧性,添加该填料的齿科3D打印复合树脂抗弯强度可达115‑142MPa,断裂韧性1.6‑2.3MPa.√m,维氏硬度63‑75HV,制备工艺简单可控,适合工业化生产。
Absstract of: USRE51101E
Disclosed is a method of designing a dental restoration for a patient, wherein the method includes providing one or more 2D images, where at least one 2D image includes at least one facial feature; providing a 3D virtual model of at least part of the patient's oral cavity; arranging at least one of the one or more 2D images relative to the 3D virtual model in a virtual 3D space such that the 2D image and the 3D virtual model are aligned when viewed from a viewpoint, whereby the 3D virtual model and the 2D image are both visualized in the 3D space; and modeling a restoration on the 3D virtual model, where the restoration is designed to fit the facial feature of the at least one 2D image.
Absstract of: USRE51102E
Dental preparation uses a tooth preparation guide custom-made for fitting with teeth of a patient. The preparation guide includes one or more guide channels for guiding a cutting tool. The preparation guide enables modification of the teeth as planned with high level of precision. A dental prosthesis for installing onto prepared teeth of the patient is provided before preparation of the teeth. The prosthesis includes features that are complementary to the prepared teeth. The prosthesis can be installed immediately after preparing the teeth using the preparation guide. With the high level of accuracy and precision in the preparation of teeth, no modification of the prosthesis would be needed for installation.
Absstract of: US12784278B1
0000 A system and method for producing color calibrated videos using a calibration slate are provided. A video of a subject is recorded with a calibration slate appearing in at least one frame of the video. The calibration slate includes printed colors that can be compared against standard colors associated with the slate to color calibrate the video. Once at least one frame of the video has been color calibrated, calibrated colors of the calibrated frame may then be utilized for color calibration of additional frames of the video.
Absstract of: WO2025099488A1
Aspects of the disclosure include cryopreserved tissue fibers and multilayer structures comprising said fibers, wherein the fibers encapsulate dissociated cells, and where the fibers and/or structured are cryopreserved prior to aggregation of the encapsulated cell population. Methods of making and using such fibers and structures are also provided.
Absstract of: US20250128050A1
0000 A console associated with a medical device is provided. The console includes a user interface, a visual indicator separate from the user interface, and a controller. The controller is configured to control an operation of the medical device, receive data from the medical device, display an indication of the data on the user interface, and change an output of the visual indicator based, at least in part, on the data.
Nº publicación: MD4349493T2 31/10/2026
Applicant:
SHAHEEN INNOVATIONS HOLDING LTD [AE]
SHAHEEN INNOVATIONS HOLDING LIMITED
Absstract of: EP4776504A2
A hookah device which attaches to a hookah. The hookah device comprises a plurality of ultrasonic mist generator devices for generating a mist for inhalation by a user. The hookah device comprises a driver device which controls the mist generator devices to maximize the efficiency of mist generation by the mist generator devices and optimize mist output from the hookah device.