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183
results.
Updated on
24/12/2025 [07:20:00]
Results 100 to 125 of 183
Absstract of: CN121074284A
本申请涉及口腔种植引导技术领域，提供了一种基于三维扫描的数字化假牙安装定位装置及其方法。该方法包括：通过口腔扫描仪扫描患者口腔生成三维口腔数字化模型；通过SegFormer分割网络，基于三维口腔数字化模型生成患者的虚拟种植体以及对应的初始植入参数；基于历史手术数据、初始植入参数、骨质密度、患者属性以及咬合力参数，采用长序列预测网络通过分段注意力机制以及网络记忆缓存机制预测虚拟种植体在骨结合后的位置偏移量及骨吸收程度获得最佳植入参数；基于最佳植入参数向用户推送包含候选定位策略的可视化动态模型，驱动口腔模型打印机得到种植导板模型和口腔环境模型，辅助用户验证候选定位策略的安装效果，提升假牙安装定位准确性。
Absstract of: WO2024200441A1
Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.
Absstract of: US2024352179A1
The present disclosure provides curable compositions comprising one or more of photo-polymerizable urethane prepolymers having alternating hard and soft blocks, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.
Absstract of: CN121059903A
本发明属于生物医用材料技术领域，提供了一种盆腔术后充填材料及其制备方法和应用。本发明的盆腔术后充填材料包含凝胶化生物膜基质和纳米弹性材料，限定了原料的质量比。本发明采用凝胶化生物膜基质，保留细胞外基质原有的三维结构、胶原纤维、非胶原蛋白及生长因子等成分，具有优异的生物相容性；采用物理交联法将凝胶化生物膜基质与纳米弹性材料交联，无需化学交联剂，无副作用；通过静电动态液体纺丝制备纳米弹性材料，促进充填材料与宿主细胞的相互融合，提高修复效果；采用天然聚合物和合成聚合物制备纳米弹性材料，赋予良好的生物相容性、稳定的支撑作用以及良好的拉伸应变，防止脏器脱垂，加快术后修复。
Absstract of: KR20250170190A
천연물 폴리머 기반의 바이오 잉크는 우수한 생체적합성과 염증 반응이 없거나 매우 적은 장점이 있으나, 기계적 강도의 부족과 물성의 조절이 어려운 문제가 있을 수 있으나, 본 출원 발명에서는 천연물 폴리머를 사용하면서도 기계적 강도의 부족 및 물성 조절의 어려움을 해결한 3D 프린팅 잉크를 제공하고자 한다. 상기와 같은 문제를 해결하과, 매실 씨 유래 카르복시메틸셀룰로오스(PCMC)의 제조방법에 의하여 제조된 매실 씨 유래 카르복시메틸셀룰로오스(PCMC)를 증류수와 10%(w/v) 농도의 DMEM 혼합물에 완전히 용해될 때까지 자석 교반기를 사용하여 250rpm으로 교반하는 PCMC혼합물용해단계(T1단계); 및 2 내지 4%(w/v)의 알긴산나트륨을 상기 PCMC혼합물용해단계에서 용해된 혼합물에 첨가하며 자석 교반기로 500rpm으로 교반하여 생성된 것을 특징으로 하는 매실 씨 유래 카르복시메틸셀룰로오스 바이오잉크의 제조방법을 제공한다. 상기와 같은 본 출원 발명의 새로운 3D 바이오프린팅 소재는 환경 친화적인 특성, 사실상 무제한의 재료 공급, 우수한 생체 적합성 및 우수한 3D 프린팅 특성으로 바이오 잉크로 널리 사용할 수 있을 것으로 판단되었다. 알긴산의 첨가량의 조절에 따라 물성 또한 조절 가능한 것이어서 기존 바이오잉크를
Absstract of: US2025361406A1
The invention relates to a radiation-curing composition for the manufacture of dental components using the DLP process or SLA process, comprising, based on the total mass of the radiation-curing composition (i) one or more radically polymerizable monomers in a combined mass fraction of 60% or more, (ii) one or more hexaarylbiimidazole compounds in a combined mass fraction in the range of 0.1 to 5%, and (iii) one or more mercaptotetrazole compounds in a combined mass fraction in the range of 0.1 to 5%, wherein the combined mass fraction of fillers in the radiation-curing composition is less than 30%.
Absstract of: WO2025247506A1
The present disclosure generally relates to a paste for carrying an active pharmaceutical ingredient (API), preferably a GLP-1 agonist and a permeation enhancer, preferably a fatty acid and/or a pharmaceutical acceptable salt thereof, such as sodium decanoate, preferably for use in a screen printing process for printing a pharmaceutical composition. The present disclosure further relates to a method for preparing a paste, and the use of a paste in an additive manufacturing process.
Absstract of: US2025367876A1
A system for additive manufacturing a medical device, the system comprising a first dispensing system, a second dispensing system, a deposition apparatus, and a deposition substrate on a surface of which the deposition apparatus is configured to deposit at least one elastomeric material into a filament. The deposition apparatus receives the at least one elastomeric material from the first and second dispensing systems in proportions effecting a desired property in the medical device. The deposition apparatus may comprise heating and/or cooling elements, a sonic vibration module, and/or a pneumatic suck-back valve. The deposition substrate may have a configuration corresponding to a desired shape of the medical device and is configured to rotate and/or translate relative to the deposition apparatus. The system comprises a controller configured to control the deposition.
Absstract of: WO2025250670A1
A three-dimensional ("3D") printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.
Absstract of: WO2025247979A1
The invention relates to a pharmaceutical formulation suitable for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to the use of this pharmaceutical formulation for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to a method for preparing a medicament in the form of unit doses by 3D printing using such a formulation.
Absstract of: US2025367422A1
A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
Absstract of: US2025367348A1
A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.
Absstract of: US2025366953A1
Systems for orthodontic treatment are provided. In some embodiments, a system includes an attachment configured to be coupled to a tooth of a patient. The attachment can include a first surface configured to contact the tooth, a second surface opposing the first surface, and one or more sidewalls connecting the first surface and the second surface. The first surface, the second surface, and the one or more sidewalls can form a solid enclosed volume having a protruding shape. The system can further include an orthodontic appliance including a shell having a plurality of teeth-receiving cavities shaped to reposition the patient's teeth from a first arrangement toward a second arrangement, and an attachment-receiving well formed in the shell. The attachment-receiving well can engage the attachment to effect a movement of at least one tooth of the patient. The attachment can have a different geometry than the attachment-receiving well.
Absstract of: US2025366922A1
A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at least four mounting holes. Another aspect of the present disclosure relates to a method for tailoring a plate for fixating bone. The method can include determining an initial design of the plate. The method can include analyzing radiation through the initial design. The method can include determining, based on analyzed radiation, if dosimetric characteristics are desirable. The method can include analyzing structural strength of the initial design. The method can include determining, based on the analyzed structural strength, if structural strength is sufficient.
Absstract of: WO2025247746A1
A method for manufacturing a medical bone connecting device (10) is proposed that serves to connect two bones (V, H) or bone parts of a human or animal patient. The method comprises at least the following steps: a.) targeted deposition (80) in a common layer (17) of one or more strands (13) of reinforcing fibers (11) embedded in a matrix material (12), b.) repetition (81) of step a.) for a plurality of successive layers (17), in order to produce a preform (18) of the bone connecting device (10), and c.) compression (82) of the preform (18) in a mold (70) to form the bone connecting device (10). The strand or strands (13) are deposited in such a way in step a.) that they follow a multiple curved path (15) without crossing themselves or each other. Furthermore, a bone connecting device (10) manufactured according to this method is disclosed.
Absstract of: WO2025250016A1
Herein is disclosed a method of manufacturing a seat unit for a wheelchair, and a seat unit for a wheelchair The method comprises the steps of determining a user's needs for support and pressure relief, and thereafter selecting a basic seat cushion module (1) and a basic backrest module (2) before 3D-printing a seat unit adaptation module (4; 5) using information about the determined support and pressure relief needs of the user, for adapting the basic seat cushion module (1) and/or the basic backrest module (2) to the user. The adaptation module (4; 5) is printed with an open 3D structure (3).
Absstract of: US2025366958A1
Systems and techniques for training one or more neural networks to automatically determine placement of a digital representation of an orthodontic appliance are disclosed including comparing one or more aspects of the second representation of a 3D printed part with one or more respective aspects of a first representation of the 3D printed part, generating a reconstruction error based on the comparing, and when the reconstruction error is greater than a predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were not correctly fabricated and when the reconstruction error is less than the predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were correctly fabricated.
Absstract of: US2025366995A1
The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.
Absstract of: US2025366981A1
A corneal inlay and pinhole lens structure for implantation into a cornea of an eye is disclosed herein. In one embodiment, a corneal inlay for implantation into a cornea of an eye includes an inlay body formed from natural tissue of a donor cornea; and a central pinhole disposed in the inlay body, the central pinhole being surrounded by a darkened bounding wall. In another embodiment, a pinhole lens structure includes an insertable pinhole body defining a through pinhole of approximately 0.9-2.0 mm in diameter with a surrounding darkened wall having an approximately 0.1-1 mm wall thickness, the insertable pinhole body configured to be inserted into a corneal pocket in a cornea of an eye.
Absstract of: US2025366979A1
Disclosed herein are devices and methods of making and use thereof.
Absstract of: US2025366978A1
Disclosed herein are devices and methods of making and use thereof.
Absstract of: US2025366997A1
The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.
Absstract of: US2025366893A1
A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and/or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and/or have bone ingrowth surface features that create a strong bond with the bone.
Absstract of: US2025366894A1
A three-dimensional (“3D”) printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.
Nº publicación: US2025369798A1 04/12/2025
Applicant:
REGENTS OF THE UNIV OF MINNESOTA [US]
Regents of the University of Minnesota
Absstract of: US2025369798A1
A skin-wearable photodetector module includes an array with a plurality of photodetectors and a plurality of optical filters, and each photodetector is configured to receive an optical input from an optical filter having a central wavelength in a wavelength range of about 100 nm to about 1000 nm. Each photodetector includes a substrate with a first major surface having an electrode thereon, and a second major surface overlying an optical filter, an anode within an interior region of the electrode, an active layer including a. ternary mixture of an electron donor, an electron acceptor, and at least one charge carrier trap material, and a cathode that contacts the active layer.
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