Alerta

CLINICIAN PROGRAMMER WORKFLOW AUTOMATION FOR IMPLANTABLE MEDICAL DEVICES

Absstract of: AU2025219161A1

The present disclosure relates to stimulation systems, comprising, e.g., an implantable medical device (IMD), such as an implantable pulse generator configured to deliver electrical stimulation to one or more nerves of a subject, or an implantable pump configured to administer one or more active agents. In some aspects, the IMD is configured to store one or more clinical state parameters (e.g., a clinical workflow stage) and/or to advertise or transmit the stored one or more clinical state parameters to a clinician programmer device. One or more settings of the IMD, and/or parameters of the administration of electrical stimulation or the active agent(s), may be set based on the one or more clinical state parameters (e.g., a clinical workflow stage), e.g., either automatically or based on instructions provided by the clinician programmer device.

CLINICAL DATA ANALYSIS

Absstract of: US20260253729A1

A method for clinical data analysis includes receiving a first 3D representation that is representative of clinical data. The first three-dimensional (3D) representation includes one or more mesh elements. The method includes computing one or more mesh element features for the one or more mesh elements and providing the one or more mesh element features as an input to a first machine learning (ML) module. The method includes executing the first ML module to encode the first 3D representation into one or more latent representations and providing the one or more latent representations to a second ML module that is different from the first ML module. The method includes executing the second ML module to classify the clinical data represented in the first 3D representation into at least one predicted classification label.

METHODS AND SYSTEMS FOR CHARACTERIZING POROSITY OF ADDITIVELY MANUFACTURED BONE SCAFFOLDS

Absstract of: US20260253203A1

A method for characterizing a bone tissue scaffold produced by an additive manufacturing process is provided. An image of the bone tissue scaffold is first captured and a boundary of the bone tissue scaffold is determined. One or more surface features of the bone tissue scaffold are subsequently detected using an edge detection algorithm, with the one or more surface features including one or more pores and/or one or more highlights. Edges that correspond to a pore using a pore filling algorithm are identified and the surface porosity of the bone tissue scaffold is thereby mapped. Systems for characterizing a bone tissue scaffold are also provided and make use of an image capture device for capturing an image of the bone tissue scaffold, as well as a processor for analyzing the image via instructions stored on the processor.

Polymeric Structures Having a Micro-Void Space and Systems and Methods for Making Same

Absstract of: US20260249546A1

Aspects of the present disclosure include methods for making a polymeric structure having a micro-void space. Methods according to certain embodiments include irradiating a polymerizable composition positioned between a build elevator and a build surface to generate a polymerizable composition having a polymerized region of the polymerizable composition having a micro-void space in contact with the build elevator and a non-polymerized region of the polymerizable composition in contact with the build surface, displacing the build elevator away from the build surface, contacting the generated micro-void space with a non-reactive composition and repeating in a manner sufficient to generate a polymeric structure having a resolved micro-void space. Systems for preparing a polymeric structure according to the subject methods are also described. Polymeric structures having a resolved micro-void space such as where the micro-void space is filled with a non-polymerizable composition are also provided.

MEDICAL DEVICES AND METHODS

Absstract of: US20260253722A1

0000 Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

POSITIONER FOR ORTHODONTIC ALIGNER

Absstract of: WO2026177259A1

The present invention relates to a positioner for an orthodontic aligner. The positioner comprises a body (120) having a three-dimensional shape, provided with an adhesive surface (126), and having a through-hole (129) formed on one side and passing through in a transverse direction, and is fixed to teeth by attaching the adhesive surface (126) to the teeth. On the basis of teeth arrangement data obtained by scanning in a state in which the body (120) is fixed to the teeth, the positioner can guide the positions for mounting the body (120) attached to the teeth to be corrected and orthodontic means formed to correspond to each of the teeth. Furthermore, by hanging a wire on the through-hole (129) and pushing or pulling the teeth, preliminary correction can be performed prior to correcting the teeth using the orthodontic means.

INTRAORAL SCANNER WITH AN ANTENNA

Absstract of: US20260248374A1

Embodiments can relate to an intraoral scanner including a projector unit configured to emit light at least onto a dental object of a patient, and an image sensor configured to acquire reflected light from at least the dental object. The scanner includes a wireless interface configured to communicate with an external device, where the communication may include 2D image data and/or 3D image data processed or raw. The scanner includes a housing accommodating the projector unit and the image sensor, and wherein the housing includes a first end and a second end, and the projector unit and the image sensor are arranged closer to the first end, and an antenna of the wireless interface is arranged closer to the second end, and wherein during a scan of an oral cavity the first end is located inside the oral cavity and the second end is not located within the oral cavity.

METHOD AND DEVICE FOR ASSESSMENT OF PERIPHERAL NEUROPATHY

Absstract of: US20260248441A1

0000 The invention relates to ways for determining, whether or not a person suffers from peripheral neuropathy. In order to make the generation of data for the determination easy for the person, the invention provides that sensor data from foot bottom pressure sensors (11, 12) used by the person to control computer games is used to determine, whether or not a person suffers from peripheral neuropathy.

Rapid 3D-Bioprinting of Microfluidic Vascular Tissue Models

Absstract of: US20260250614A1

0000 A novel vascular tissue model is disclosed. The model uses a rigid 3D printed scaffold. This scaffold includes one or more scaffold microfluidic channels, two or more inlets, and a central chamber. The central chamber contains a hydrogel, and the hydrogel includes a hydrogel microfluidic channel.

TECHNIQUES FOR DETECTING ATRIAL FIBRILLATION

Absstract of: US20260248438A1

Methods, systems, and devices for atrial fibrillation (AFib) detection are described. A method may include acquiring physiological data collected from a user via a wearable ring device, the physiological data including temperature data and motion data, and identifying that a measurement trigger condition for AFib has been satisfied based on the temperature data satisfying a temperature threshold and the motion data satisfying a motion threshold. The method may include sampling photoplethysmogram (PPG) data for the user via the wearable ring device based on identifying satisfaction of the measurement trigger condition, and classifying one or more AFib states based on the sampled PPG data. The method may further include causing a GUI of a user device to display an indication of the one or more AFib states.

PHOTOCURABLE REINFORCEMENT OF 3D PRINTED HYDROGEL OBJECTS

Absstract of: US20260248919A1

The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

IMAGE-GUIDED NAVIGATION DEVICES, ADAPTERS AND SYSTEMS WITH OPTICAL DISTANCE SENSOR BASED MARKERLESS REGISTRATION, DEPTH DETECTION, IMAGE-GUIDED PREDICTION AND TRAINING MODELS

Absstract of: US20260248563A1

A navigation device, adapter or system for real time three-dimensional (3D) depth sensing through endoscope, a laparoscope, an arthroscope, a cystoscope, a ureteroscope, a bronchoscope, a sinuscope, and a borescope devices. The navigation devices or systems can include a modular, releasable adapter that enables LiDAR or other optical time-of-flight sensor with the devices. The devices, adapters or systems are operable to generate sub-millimeter precision reconstructions of the viewed surfaces and can register the surfaces to scans, such as preoperative scans, to facilitate accurate, image-guided procedures, particularly those procedures involving precise actions, such as surgical procedures performed on rigid anatomy. Applications include surgical guidance, augmented reality visualization, distance-based signal normalization, 3D measurement, luminal traversal tracking, and robotic control, all using off-the shelf endoscopes and surgical cameras as well as borescopes. The time-of-flight sensor may be sensitive to a subrange of visible light such that the system readily supports simultaneous acquisition of visible light imaging, fluorescence, and depth data, with calibration workflows for wide field of view optics and adaptive software control of focus, illumination, and display rendering.

ILLNESS DETECTION BASED ON NERVOUS SYSTEM METRICS

Absstract of: US20260248462A1

Methods, systems, and devices for illness detection are described. A method may include receiving heart rate variability (HRV) data associated with a user from a wearable device, the HRV data collected via the wearable device throughout a first time interval and a second time interval subsequent to the first time interval. The method may include inputting the HRV data into a classifier, and identifying a satisfaction of deviation criteria between a first subset of the HRV data collected throughout the first time interval and a second subset of the HRV data collected throughout the second time interval. The method may include causing a graphical user interface (GUI) of a user device to display an illness risk metric for the user based on the satisfaction of the deviation criteria, the illness risk metric associated with a relative probability that the user will transition from a healthy state to an unhealthy state.

ADDITIVELY MANUFACTURED WIRE PRODUCTS FORMED FROM NICKEL-TITANIUM SHAPE MEMORY ALLOYS

Absstract of: US20260249356A1

0000 A method of producing a wire product from a nickel-titanium shape memory alloy, and a wire product produced by such method. The method includes consolidating a nickel-titanium shape memory alloy to a preform using an additive manufacturing process. Thereafter, the preform may be subject to a hot working process, including heating the preform and deforming the preform, such as by, forging, extrusion, rolling, swaging, and the like. The hot-worked preform may be annealed following hot working. The preform may then be subjected to one or more cold working processes including drawing, swaging, rolling, and the like. Annealing may also occur after cold working. The hot and cold working processes may impart significant diameter reduction to form the wire product.

CERAMIC SLURRY COMPOSITION FOR PHOTOCURABLE 3D PRINTING

Absstract of: WO2026177311A1

The present invention relates to a ceramic slurry composition for photocurable 3D printing and, more specifically, to a ceramic slurry composition for photocurable 3D printing, which uses a ceramic or glass-ceramic powder, thereby enabling a dental prosthesis to exhibit esthetics similar to natural teeth, and furthermore, comprises a non-reactive diluent, thereby enabling the preparation of a low-viscosity slurry comprising a high content of ceramic or glass-ceramic powder, and in which the slurry thus prepared is easy to mold using 3D printing, and a high-quality three-dimensional molded article can be manufactured upon 3D printing.

Classification of tumor microenvironments

Absstract of: AU2026205056A1

The disclosure provides population and non-population-based classifiers to categorize patients and cancers. The population-based classifiers disclosed integrate signatures, i.e., global scores related to the expression of genes in particular gene panels. The non-population- based classifiers are generated using machine-learning techniques (e.g., regression, random forests, or ANN). Each type of classifier stratifies patients and cancers according to tumor microenvironments (TME) as biomarker-positive or biomarker-negative, and treatment decisions are then guided by the presence/absence of a particular TME. Also provided are methods for treating a subject, e.g., a human subject, afflicted with cancer comprising administering a particular therapy depending on the classification of the cancer’s TME according to the disclosed classifiers. Also provided are personalized treatments that can be administered to a subject having a cancer classified into a particular TME, and gene panels that can be used for identifying a human subject afflicted with a cancer suitable for treatment with a particular therapeutic agent. un u n

AN ORTHOPAEDIC IMPLANT

Absstract of: WO2026175863A1

The present invention relates to a 3D-printed orthopaedic implant (201, 301, 401) comprising a non-porous support portion (205, 305, 405) and a porous osteoconductive scaffold (203, 303, 403), wherein the porous osteoconductive scaffold forms at least 60% of the volume of the 3D-printed orthopaedic implant, and the 3D-printed orthopaedic implant comprises at least one discrete hollow tunnel (207a-e, 307a-c, 407a-c) extending into the osteoconductive scaffold, each discrete hollow tunnel being independently configured to allow insertion of a solid osteoinductive filament (101a, b) therein, and wherein each discrete hollow tunnel independently has: a volume of 7% or less of the 3D-printed orthopaedic implant; a substantially uniform cross-section; and a length that is at least three times greater than its width. A solid osteoinductive filament operable to be introduced into the 3D-printed orthopaedic implant, and a kit formed therefrom, are also encompassed.

SYSTEMS AND METHODS FOR SUPPORTING ASSEMBLY OF A COLLECTION OF OBJECTS

Absstract of: WO2026176339A1

The present disclosure provides automated systems and methods for supporting assembly of a collection of objects used for a task. In certain embodiments, the systems and methods support assembly of surgical trays for use in a surgical or other medical setting. A method may comprise receiving images from a camera. The images may be analyzed to automatically identify objects in the images and to automatically determine that the objects have been placed in a container. A container inventory corresponding to a task for the container may be updated that the objects have been placed in the container. Machine vision modules and checking a weight of a container may both aid in determining whether the objects have been placed in the container. Thus, the method may automate the process of assembly of a collection of objects that may lead to a reduction of errors.

MANUALLY ROTATED MEDICAL IMAGING SYSTEMS AND ASSOCIATED METHODS

Absstract of: WO2026178497A1

Systems, methods, and devices for medical imaging are disclosed herein. In some embodiments, a method for imaging an anatomic region includes receiving, from a detector carried by an imaging arm of a mobile C-arm apparatus, a plurality of 2D images of the anatomic region. The images can be obtained during a non-isocentric manual rotation of the imaging arm. The method can also include receiving data indicative of a plurality of poses of the imaging arm during the manual rotation. The method can further include generating, based on the 2D images and the data, a 3D reconstruction of the anatomic region.

PHYSIOLOGIC RESPONSE MONITOR MOUTH WEARABLE

Absstract of: US20260248442A1

0000 Various components, methods, and systems are provided herein for monitoring physiological responses associated with force-impact events using a mouth-wearable sensing device positioned within an oral cavity of a subject. In some embodiments, the device integrates inertial sensing, force sensing, temperature sensing, and optical physiological sensing on a compact intraoral substrate and transmits physiological data wirelessly to an external computing device for analysis and reporting. In some embodiments, the mouth-wearable sensing device is customized using intraoral scan data to generate a three-dimensional oral cavity model and to position one or more sensors to align with anatomical landmarks when worn.

INFORMATION PROCESSING DEVICE, IMAGE GENERATION METHOD, AND NON-TRANSITORY COMPUTER-READABLE MEDIUM

Absstract of: US20260253275A1

An information processing device includes a digitizing unit for generating numerical data indicating a time-series change of a biological signal from first image data indicating a waveform of the biological signal, and an image generation unit for generating second image data indicating a waveform of the biological signal by using the generated numerical data. The generated second image data can be used as training data for machine learning or can be used for decision making by a medical worker in diagnosis of a subject to be measured for the biological signal.

ALLERGEN TEST PATCHES FOR AUTOMATED ALLERGIC CONTACT DERMATITIS PATCH TESTING

Absstract of: WO2026178496A1

An allergen test patch includes a patch substrate having a top surface and a bottom surface, at least one allergen well coupled to the bottom surface of the patch substrate, and a border removably coupled to and surrounding the patch substrate. The border has a top surface and a bottom surface. An adhesive is disposed on the bottom surface of the border to adhere the border to a skin surface of a subject, thereby removably coupling the patch substrate to the skin surface of the subject. When the border is adhered to the skin surface of the subject, removing the patch substrate from the border retains the border on the skin surface of the subject. This design allows for improved allergen testing by maintaining a defined test area on the skin after removal of the allergen-containing substrate.

AI-DRIVEN MEDICAL INTAKE ASSISTANT

Absstract of: US20260253714A1

An AI-driven medical intake assistant system includes a computing device having a processor and memory configured to execute an intake module, an abnormality detection module, and an electronic health record (EHR) integration module. The intake module presents a conversational interface that dynamically selects patient intake questions using a rule-based branching decision tree with clinical topic tags and transition rules. One or more connected diagnostic devices automatically capture patient vital sign measurements, including blood pressure, temperature, pulse oximetry, or weight, and transmit the measurements to the computing device. The abnormality detection module compares captured measurements to predefined threshold values or historical baseline data retrieved from the EHR and generates provider-facing alerts when deviation thresholds are exceeded. The EHR integration module maps patient responses and vital sign measurements into predefined structured EHR fields prior to a provider consultation.

ELECTROCARDIOGRAM EVALUATION USING Z-SCORE BASED STANDARDS

Absstract of: US20260248436A1

0000 Embodiments include an automated non-invasive method of assessment of an examined subject utilizing an electrocardiogram (ECG) system including: an electronic unit configured to connect to the examined subject, a memory unit configured to contain a database of Z-score-based nomograms of a first set of ECG variables from historic data of healthy individuals, a computer interface system, an adaptive confirmatory enhancement (ACE) module connected to various machine learning algorithms, an oversAIght module with artificial intelligence determining which algorithm to use, and a report generator, the method comprising: determining, by the computer interface system of the ECG system, a disease diagnosis of the examined subject based on a determination that the digital ECG values of the second set of ECG variables of the examined subject are abnormal.

Integrated AI-Powered Wearable Device and Retinal Imaging System for Early Home-Based Screening and Detection of Ocular Tumors

Nº publicación: US20260253215A1 27/08/2026

Applicant:

YAN ETHAN [US]
Yan Ethan

Absstract of: US20260253215A1

The RetinAI invention provides a novel integrated system designed for home-based early screening and detection of ocular tumors and retinal diseases, leveraging advanced artificial intelligence and optical imaging technology. The system comprises a wearable headset with precisely aligned imaging sensors and dual-mode illumination sources for capturing extraocular images to detect leukocoria and intraocular retinal images for direct visualization of tumors, eliminating the need for pharmacological pupil dilation. On-device deep learning models, including representative object detectors and convolutional neural networks, provide real-time diagnostic outputs. Clinical validations demonstrate RetinAI's capability to detect leukocoria as small as 1 mm in diameter and identify a broad spectrum of retinal diseases, confirming its significant potential to enhance ocular health screening, particularly in underserved and resource-limited settings. The cost-effective, user-friendly, and portable nature of the RetinAI system positions it as an essential tool for improving access to ophthalmic care globally.