Alerta

一种透超声皮肤制备方法

Absstract of: CN120422390A

本发明提供了一种透超声皮肤制备方法，属于生物医学技术领域，包括如下步骤：S1：采集患者平扫的胸部CT；S2：重建需要人造皮肤的位置，做出模具；S3：计算需要人造皮肤的容量，配置填充材料；S4：向模具内倒入填充材料，使填充材料固化，然后脱模，即得到透超声皮肤模型。本发明制得的皮肤模型可用在动静脉穿刺上，可以透超声，用穿刺针穿刺后不会漏水，如轻微的漏水可轻微按压漏水的位置，过1分钟左右会缓解漏水的位置，真实的模拟了人皮肤的性质，可以广泛应用在医学教学、临床上的手术模拟、手术培训和操作训练。

一种3D打印义乳的制备方法

Absstract of: CN120420518A

本发明公开了3D打印义乳的制备方法，制备步骤包括如下：S1，确定色料：该步骤主要是为确定TPE本色料的颜色。本发明通过3D打印义乳的制备方法实现一种新型的义乳制备方法，通过实现纯TPE材料的3D打印，并且在颜色、大小、形状和香味可供患者选择，从而实现了义乳的个性化定制，满足患者乳腺外观的双侧对称的美学需求，同时弥补了传统义乳按照号码生产，对于过小、过大乳房患者均无合适尺码的问题，同时通过材料的疏水特性，可有效解决透气微孔储水问题，在日常佩戴中可有效做到通风透气，避免汗液潴留，也可以扩展应用场景如温泉、游泳等，极大改善用户的生活质。

一种可用于逐层式光固化3D打印的水凝胶微球基生物墨水

Absstract of: CN120420502A

本发明公开了一种可用于逐层式光固化3D打印的水凝胶微球基生物墨水，属于生物医用和组织工程材料领域。本发明提出了一种含有可光交联的水凝胶微球与少量交联剂(微球可自交联的情况可不加)、光引发剂和光吸收剂组成的生物墨水，在逐层式光固化3D打印中通过水凝胶微球间的光交联反应形成打印结构。该类生物墨水所打印的物件由微球紧密堆积的三维结构组成，微球间的孔隙有效提高了生物墨水的细胞包载能力及生物活性，微球的模块化性可以实现打印复杂异质结构。本发明中的生物墨水具有较小的溶胀性、优秀的打印性能和负载细胞的能力，在负载细胞打印和多材料打印实验中得到了具体应用，具有良好的生物制造及组织工程应用前景。

一种髋关节聚氨酯人工盂唇制备方法及应用

Absstract of: CN120420504A

本发明提供一种髋关节聚氨酯人工盂唇制备方法，将聚氨酯经3D打印制成圆环状聚氨酯支架，随后将圆环状聚氨酯支架表面经过聚多巴胺修饰。本发明一种髋关节聚氨酯人工盂唇制备方法，通过聚多巴胺(PDA)表面修饰技术增强其生物相容性与细胞粘附性，用于修复髋臼盂唇损伤并促进纤维软骨再生。

3D 3D printable bioabsorbable material composition for bone regeneration and preparation method thereof

Absstract of: KR102842037B1

본 발명은, 콜라겐, 젤라틴, 광개시제, 광개시보조제, 촉진제, 광감각제 및 재생필러를 포함하는, 골조직 재생 유도용 생체흡수성 3D 프린팅 복합 소재 조성물 및 이의 제조방법에 관한 것으로, 상기 골조직 재생 유도용 생체흡수성 3D 프린팅 복합 소재 조성물은, 3D 프린팅에 적합한 점도 및 물성을 가져 3D 프린팅시 원하는 형태로 용이하게 성형할 수 있다. 뿐만 아니라, 광흡수율이 높아 전체적으로 균일하게 광경화되므로, 균일한 품질의 출력물 제조가 가능하며, 설계된 형태와의 오차가 극히 낮아, 개별 환자 맞춤형 3D 프린팅 복합 소재의 제조가 가능하다.

3D 3D printing resin with improved strength and formability and method for manufacturing the same

Absstract of: KR102842142B1

본 발명은, 아크릴레이트 고분자 혼합물; 광중합 첨가제 혼합물; 개질 나일론 파우더; 및 충전제;를 포함하는, 강도 및 성형성이 향상된 3D 프린팅용 레진 조성물에 관한 것으로, 상기 아크릴레이트 고분자 혼합물은, UDMA(urethane dimethacrylate), BIS-GMA(bisphenol A-glycidyl methacrylate), BIS-EMA(ethoxylated bisphenol A dimethacrylate) 및 TEGDMA(triethylene glycol dimethacrylate)를 포함하는, 강도 및 성형성이 향상된 3D 프린팅용 레진 조성물 및 이의 제조방법에 관한 것이다.

一种体外调节的单向滑动生长棒

Absstract of: CN120392262A

本发明涉及骨科医疗器械技术领域，具体涉及一种体外调节的单向滑动生长棒，包括：近端套筒、远端套筒、卡扣部件、弹簧驱动部件以及可拆卸预弯棒，远端套筒的内筒壁开设有直线滑槽，近端套筒外壁形成直线滑条，近端套筒的一部分套接在远端套筒的内筒内部，远端套筒的内筒设有所述弹簧驱动部件，远端套筒的外壁安装有卡扣部件，滑动生长棒两端分别连接有可拆卸预弯棒，卡扣部件内包括卡扣外壳、限位部件和单向滑动部件；本发明能够提高生长棒的性能。

3D打印多孔金属-陶瓷组配式复合植入体及其制备方法和应用

Absstract of: CN120392380A

本发明涉及一种3D打印多孔金属‑陶瓷组配式复合植入体及其制备方法和应用。3D打印多孔金属‑陶瓷组配式复合植入体:包括由3D打印一体式多孔金属模块和3D打印一体式多孔陶瓷模块复合在一起的多孔金属‑陶瓷植入体本体、包置于多孔金属‑陶瓷植入体本体外周的网状金属保护体一起形成的能够与缺损部位骨组织的外形和结合面精准匹配的组配式复合植入体。发明所述复合植入体，具有成骨环境调控功能化，能达到即时恢复缺损骨组织的运动功能，改善骨缺损部位组织微环境，加速新骨再生并引导新骨向多孔金属植入物内部生长，实现骨/金属植入物界面的快速骨整合，以及陶瓷降解后3D打印多孔金属植入物/自体骨融合式修复的远期治疗效果。

用于制造正畸器具的包含可聚合反应性稀释剂的可固化组合物

Absstract of: US2024191006A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

一种3D打印微针及其制备方法和其应用

Absstract of: CN120392633A

本发明涉及一种3D打印抗菌微针，所述微针为由载药针尖层、针体层、载药储库层和基底层制成的多层仿生蘑菇状结构，其中，载药针尖层：针体层：载药储库层：基底层的体积比为1:1:20‑50:20‑50；载药针尖层采用可溶性聚乙烯吡咯烷酮负载纳米复合体后制得；针体层由甲基丙烯酰化聚赖氨酸和甲基丙烯酰化透明质酸钠浓缩后光共交联后制得；载药储库层由采用可溶性聚乙烯吡咯烷酮负载纳米复合体后制得；基底层由不可降解的聚乙二醇二丙烯酸酯光交联后制成。本发明采用3D打印联合聚二甲基硅氧烷翻模法一体化制备微针，所述微针具有优异的机械性能和穿刺性能，利于在创伤部位实现自主给药，实现药物的精准释放、高效摄取及“组织渗透‑细菌靶向‑基因沉默”的级联效应，显著缩短创面愈合时间，显著提高抗菌药物的靶向递送效率、生物利用度和安全有效性，攻克核酸药物难以用于抗创面感染的问题。

一种用于皮肤及毛囊再生的预制化生物3D打印人工皮肤制备方法

Absstract of: CN120393113A

本发明提供一种用于皮肤及毛囊再生的预制化生物3D打印人工皮肤制备方法，主要包含GelMA、HAMA和皮肤干细胞。生物3D打印人工皮肤的制备方法是首先配置每毫升含50毫克GelMA和5毫克HAMA的水凝胶溶液，再加入107‑108个皮肤干细胞，真皮干细胞和表皮干细胞比例为1:2。最后，将细胞与水凝胶混合也转入注射器冷藏3分钟后移入生物3D打印机中，按预设打印参数制备不同模型的人工皮肤。本发明所优化的水凝胶材料具有优良的可打印性，较低的溶解度和溶胀率以及稳定的力学性能。本发明采用的水凝胶材料能够与皮肤干细胞配合促进皮肤干细胞的干性提高，更利于皮肤的修复与毛囊的再生。本发明制备的生物3D打印人工皮肤可立即或体外培养后用于伤口中促进皮肤及毛囊。

3 SYSTEMS AND METHODS OF USING THREE-DIMENSIONAL IMAGE RECONSTRUCTION TO AID IN ASSESSING BONE OR SOFT TISSUE ABERRATIONS FOR ORTHOPEDIC SURGERY

Absstract of: US2024428538A1

Systems and methods for calculating external bone loss for alignment of pre-diseased joints comprising: generating a three-dimensional (“3D”) computer model of an operative area from at least two two-dimensional (“2D”) radiographic images, wherein at least a first radiographic image is captured at a first position, and wherein at least a second radiographic image is captured at a second position, and wherein the first position is different than the second position; identifying an area of bone loss on the 3D computer model; and applying a surface adjustment algorithm to calculate an external missing bone surface fitting the area of bone loss.

一种用于口腔修复材料的3D打印辅助设计系统

Absstract of: CN120392358A

本发明涉及三维模型设计技术领域，且公开了一种用于口腔修复材料的3D打印辅助设计系统，包括数据采集模块、初始模型设计模块、设计优化模块以及结果输出模块；通过设有初始模型设计模块与设计优化模块，有利于基于构建个体的口腔模型，从牙型数据库中选取与个体匹配度最高的修复体模型作为初始模型，基于改进后的优化算法获取最优调整参数，根据最优调整参数对初始模型的修复体设计参数进行调整优化，获取优化后的修复体模型；通过精确的数据对修复材料进行智能优化设计，结合人体的牙型数据库与患者的个体数据，进行个性化的修复材料设计的优化，进而同时保证牙齿外形的美观性与实用性。

一种载姜黄素3D生物打印墨水及其制备方法与应用

Absstract of: CN120393112A

本发明公开了一种载姜黄素3D生物打印墨水及其制备方法与应用，属于3D生物打印材料技术领域。该制备方法具体包括以下步骤：(1)包载物的制备；(2)姜黄素纳米粒子溶液的制备；(3)载姜黄素3D生物打印墨水的制备。本发明采用物理混合的方法将姜黄素纳米粒子溶液和高分子粉末混合，由此制得的载姜黄素3D生物打印墨水具有显著的抗炎活性和较好的促进伤口愈合效果，同时具有较好的可打印性和ROS响应释放特性，可用于载药医疗器械，对提高姜黄素的给药精确性具有重要意义。而且，本发明制备方法操作简单，效果显著，应用范围广，能拓宽载姜黄素3D生物打印墨水的应用范围，具有良好的应用前景。

含图案的液体及其制造方法

Absstract of: AU2023419073A1

The purpose of the present invention is to provide: a liquid with a pattern, said liquid including a pattern that can produce, in a liquid matrix, a sensation such as a color, a flavor, a texture, or a tactile sensation, said pattern having good stability; and a method for producing a liquid with a pattern which makes it possible to stably form a pattern in a liquid matrix. The present invention relates to, for example, a liquid with a pattern, said liquid including, in a liquid matrix, a pattern formed by microparticles and/or a pigment, wherein the liquid matrix is pseudoplastic fluid and is accommodated in a container.

用于制造金属嵌入式医疗植入物和装置的三维打印方法

Absstract of: WO2024093647A1

Three-dimensional (3D) printing methods for making metal-embedded medical implants and devices are provided. The newly developed 3D printing technology and surface modification method will contribute to the wider application of 3D-printed patient-specific products in many medical fields showing excellent clinical safety.

一种3D打印肝癌切除手术导板的制造方法

Absstract of: CN120392288A

本发明涉及医学领域，且公开了一种3D打印肝癌切除手术导板的制造方法，包括以下步骤：CT数据采集：进行肝脏增强扫描，获取多期DICOM格式数据；应用3D可视化软件，以门静脉4级分支流域为基础，规划肝脏切除范围并确定手术切面；应用3‑matic Medical等工程软件，基于手术切面设计肝脏表面及实质内手术导板；使用3D打印机将数字手术导板打印为实物模型，用于手术定位与导航。传统的肝癌手术规划建立在标准的肝脏分段方法之上，缺乏个性化。目前主要应用肝蒂阻断法及染料注射法进行手术路径导航，存在操作复杂、成功率低、重复性差等问题。本发明为一种3D打印肝癌切除手术导板的制造方法，通过3D数字技术实现手术科学规划与精确导航。通过本技术方法提高手术的根治性与安全性，增进肝癌治疗效果。

基于柔性糖牺牲载体的可注射中空支架及其制备方法

Absstract of: CN120393118A

本发明涉及一种基于柔性糖牺牲载体的可注射中空支架及其制备方法，将蔗糖、果糖、葡聚糖、葡萄糖混合溶解到蒸馏水中，高温持续搅拌得到粘稠溶液，高温交联得到糖打印材料；利用糖打印材料在平面内打印柔性糖网平面基材，为软质柔性可形变状态；对柔性糖网平面基材进行塑形，得到柔性糖牺牲载体，将PCL涂层液多层涂覆到柔性糖牺牲载体，得到双层支架；置于蒸馏水中溶解柔性糖牺牲载体，得到可注射中空支架。本发明通过精确控制柔性糖牺牲载体中各组分的比例，令其性状可一段时间内维持软质柔性可形变状态，仅需要在二维平面内打印出基材，然后塑型处理，实现对特定器官形态的模拟，提高了复杂器官重建的准确性和可行性。

椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法

Absstract of: CN120393108A

本发明公开了椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法，将YbCl3·6H2O与TmCl3·6H2O/ErCl3·6H2O/PrCl3·6H2O按摩尔比(Tm:Er＝1:0.2～0.5或Tm:Er:Pr＝1:0.2～0.5:0.1～0.3)溶于水，与EDTA‑2Na、NaF、AgNO3反应制得NaYbF4:M/Ag；再经SiO2包覆和CTAB/硅烷改性获得硅烷改性NaYbF4:M@SiO2复合粒子；再将其与热/光固化硅橡胶单体、引发剂及羟基磷灰石混合制得近红外光‑热协同固化硅橡胶墨水。该材料可实现高精度3D打印，兼具良好生物相容性和力学性能，适用于椎间融合器医疗硅橡胶制品的制备。

透明な歯科矯正アタッチメントを製造するための硬化性組成物

Absstract of: CN119584936A

The present invention relates to a curable composition comprising: a (meth) acrylate free of urethane moieties, a urethane (meth) acrylate, a photoinitiator, discrete filler particles having an average particle size in the range of 10 nm to 40 nm and having been surface treated with a silane surface treatment agent, the silane surface treatment agent is selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both, and the discrete filler particles are present in an amount of 20% by weight or more, the curable composition further comprising an additive selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both. The curable composition does not contain, in each amount of 2 wt% or more, aggregate of nano-sized particles, fumed silica, wt% relative to the curable composition, alone or in combination: aggregate of nano-sized particles, aggregate of nano-sized particles, fumed silica.

一种牙模3D打印控制系统

Absstract of: CN120396331A

本发明提供了一种牙模3D打印控制系统，包括：LCD屏幕、用于发射紫外光的UV光源、用于附着已固化模型的成型平台、盛放液态陶瓷填充光敏树脂的料槽、墨盒、带动成型平台与墨盒移动的Z轴和X轴电机、丝杠以及传感器。所述墨盒外部配备磁铁结构，可紧密吸附在料槽的钢板上；磁铁外围集成刮刀组件，使得墨盒在运动过程中能够同时对浆料进行均匀刮平；墨盒顶部配备墨盒盖。本系统不仅优化了料槽设计，还配备了自动供料墨盒，以在打印过程中动态补充浆料，同时利用墨盒中的刮刀组件确保浆料均匀分布，优化固化质量。这种设计有效避免了传统光固化3D打印机因浆料供给不足或分布不均而导致的打印缺陷。

3D BIOPRINTED HYDROGEL MICROFLUIDIC SYSTEMS AND PERFUSION BIOREACTORS FOR ENGINEERING VASCULARIZED TISSUE CONSTRUCTS

Absstract of: WO2025160474A1

3D bioprinted hydrogel microfluidic systems and perfusion bioreactors for engineering vascularized tissue constructs are provided. An example of an internally perfusable scaffold comprises an exterior surface, a body, a first port, and an interior wall. The first port comprises a first coupling feature configured to engage a fitting and form a fluid tight seal therewith. The first interior wall defines a fluid cavity extending into the body from the first port. The scaffold comprises a hydrogel.

Spinal Implant With Porous And Solid Surfaces

Absstract of: US2025241766A1

A spinal implant including porous and solid portions is disclosed. The implant includes porous portions on upper and lower surfaces and in an interior thereof. Methods of manufacturing and implanting such implants are also disclosed.

FEATURES FOR IMPLANTS WITH A REDUCED VOLUMETRIC DENSITY OF SURFACE ROUGHNESS

Absstract of: US2025241765A1

The invention disclosed herein includes implant features that can be used, in some embodiments, on devices with a volumetric density of less than about 100 percent and devices with a surface roughness of some value. The implant features include one or more protrusions mounted on the forward edge of an implant that can ease the distraction of tissue during implantation and reduce the occurrence of damage during a manufacturing process. In some embodiments, the protrusions have gaps in a non-axial direction with respect to the implant to allow axial compression with respect to the protrusions. In some embodiments, the protrusions have a circumferential gap between them and a body of a device to reduce any impact on the device's elastic modulus.

Ceramic Inkjet Ink Compositions for Printing on Dental Restorations

Nº publicación: US2025241829A1 31/07/2025

Applicant:

ZIMA INT INC D/B/A DANDY [US]
Zima International, Inc. d/b/a Dandy

Absstract of: US2025241829A1

A method for manufacturing a ceramic inkjet ink for printing on a dental material substrate includes processing solid particle components to a particle size from 0.8 to 1 m, at a particle size distribution of D98 and adding an effective amount of additives to the solid particle components to produce the ink capable of being dispensed from an inkjet printhead onto a surface of a 3-dimensional dental material substrate having an irregular shape and uneven surfaces, while the 3-dimensional dental material substrate is simultaneously translated and rotated under the inkjet printhead.