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180
results.
Updated on
15/07/2025 [07:14:00]
Results 150 to 175 of 180
Absstract of: US2025195196A1
The development of devices for a functional cure for diabetes by mimicking native pancreatic tissue for production of all pancreatic hormones. A physiologically and mechanically biocompatible artificial pancreas, wherein the pancreas comprises a combination of a PVA hydrogel combined with cells selected from the group consisting of islets; clusters of islets; Beta cells, and combinations of islets and Beta cells. The bioartificial pancreas contains vascular grafts therein or thereon a wall of the pancreas so that said grafts are an integral part of the wall of the bioartificial pancreas. The grafts can be anasmotized to living blood vessels in the body.
Absstract of: US2025195230A1
A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.
Absstract of: WO2025127247A1
A method for manufacturing a patient-customized wound dressing integrated with microneedles, and a patient-customized wound dressing integrated with microneedles, manufactured through same, are provided. A wound dressing is manufactured through 3D bioprinting by using a photopolymerizable biocompatible biodegradable bioink, and then microneedles are formed on the wound dressing through two-photon polymerization (2PP) printing by using the photopolymerizable biocompatible biodegradable bioink, and thus the patient-customized wound dressing integrated with microneedles is manufactured.
Absstract of: WO2025128946A1
Disclosed herein are devices and methods of making and use thereof.
Absstract of: WO2025127906A1
The present invention relates to 3D-printed anatomical models with flexible photopolymerisable coatings that allow the production of solid hollow models, which may be geometrically highly complex, with high anatomical fidelity and high optical translucency. The piece of the invention mainly acquires these advantageous technical features as a result of the use of coatings that can be photopolymerised by means of step-growth mechanisms or hybrid polymer reactions, as is achieved with thiol-ene chemistry, also called click chemistry or thiol-Michael additions, which may be mediated by free radicals or catalysts.
Absstract of: WO2025127798A1
The present invention relates to a strontium-emitting 3D printing scaffold for promoting bone cartilage regeneration and a method for manufacturing same. The scaffold continuously maintains the emission of a triad of ions including strontium (Sr), silicate (Si), and calcium (Ca) to promote cell migration to a damaged site, and has a hierarchical porous structure, and thus enhances tissue regeneration by increasing cell engraftment, immune regulation, and angiogenesis, and exhibits an excellent anti-inflammatory effect. Therefore, the scaffold can be effectively used for the regeneration of damaged bone and cartilage tissue.
Absstract of: WO2025128987A1
Described are continuous manufacturing methods using 3D printing or any similar additive manufacturing technology to produce pharmaceutical ASDs. Manufacturing methods include preparing printing ink including API and polymeric carriers. The printing ink is accurately deposited onto a deposition surface by forming printing ink droplets by using an electromagnetic DoD 3D printing device to form an ASD printed product. The ASD printed product has improved solubility and bioavailability than the API in crystalline form.
Absstract of: WO2025124741A1
The instant invention relates to a powder layer for use in 3D binder jetting printing comprising a hydrolyzed and functionalized starch compound. It also relates to a process for 3D binder jetting printing using the same. It also relates to products, in particular solid dosage forms, obtained thereof by 3D binder jetting printing.
Absstract of: US2025195231A1
Systems, devices, and methods are provided for orthopedic implants. The implants may include a base member, such as an acetabular shell or an augment, that is configured to couple with an augment, flange cup, mounting member, or any other suitable orthopedic attachment.
Absstract of: US2025195174A1
Dental appliances for treatment of a patient's dentition are provided. In some embodiments, a dental appliance includes a plurality of 3D printed polymer layers, where the plurality of 3D printed polymer layers includes a plurality of sequentially polymerized appliance cross-sections. The dental appliance can include an appliance shell formed from the plurality of sequentially polymerized appliance cross-sections. The appliance shell can include a plurality of tooth receiving cavities formed from the plurality of sequentially polymerized appliance cross-sections, the plurality of tooth receiving cavities arranged to receive a dentition and to exert one or more forces on the dentition, and a plurality of variable thickness regions formed from the plurality of sequentially polymerized appliance cross-sections. The plurality of variable thickness regions can include a corresponding plurality of different appliance thicknesses, and the plurality of variable thickness regions can be arranged to implement one or more treatment outcomes.
Absstract of: US2025195175A1
The present disclosure provides polymerizable composition that can produce desirable stain resistant polymeric materials, polymer compositions, and/or photo-curable resins. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Absstract of: US2025197658A1
This disclosure provides stable polymerizable resin compositions comprising one or more antioxidant stabilizers to prevent undesired polymerization and/or oxidation of polymerizable components as well as undesired depletion of photoinitiators in the polymerizable resin composition. Such polymerizable resin compositions can be used to produce polymeric materials with properties suitable for use in various mechanical appliances, such as orthodontic appliances.
Absstract of: US2025195723A1
Embodiments relate to granular hydrogel bioinks with preserved interconnected porosity for extrusion bioprinting and methods of use and making thereof. The granular hydrogel bioinks comprise hydrogel particles and materials/methods to reversibly connect them to each other without compromising void spaces. These materials/methods include but are not limited to nanoparticles, wherein the nanoparticles are absorbed onto the microgels and wherein the nanoparticles are configured to allow for electrostatic bonding of the microgels. These materials/methods can also include reversible functional groups, selected from guest-host groups and/or dynamic covalent bond forming groups.
Absstract of: US2025197659A1
There is provided a bioink for bioprinting a porous three-dimensional hydrogel structure, the bioink comprising an aqueous medium; and granular crosslinkable hydrogel precursor particles suspended in the aqueous medium, wherein the granular crosslinkable hydrogel precursor particles have an average size of from 100 microns to 500 microns, and wherein under suitable crosslinking conditions, the granular crosslinkable hydrogel precursor particles crosslink and adhere to one another, to form the porous three-dimensional hydrogel structure having pore diameters in the range of from 20 microns to 200 microns. There is also provided a method of forming a porous three-dimensional hydrogel structure using the bioink disclosed herein and a porous three-dimensional hydrogel structure obtained from said method.
Absstract of: US2025197789A1
A reinforcing and scaling construction for a bioprinted tissue model, which comprises a casing and sealing bioink, the casing comprising an inner module comprising a casing base (1) and a perforated cover (2), and an outer module comprising a container (3) comprising technological valves (5), an outer cover (4) and plugs (6) for technological valves (5). The invention also relates to a method for assembling the reinforcing and sealing construction.
Absstract of: US2025197813A1
A method For manuFacturing a perFusable three-dimensional tissue model, containing therein a channel distributed across its entire structure, enabling the Flow oF Fluids, wherein bioprinting a vascular system with the extrusive method using bioink, the walls opening and closing the channel in its upper part being printed parallel to the channel axis, and bioprinting oF the model body with the extrusive method using bioink, the bioink For printing the body being diFFerent From the bioink used For bioprinting the vessels, placing the resulting system in an incubator, in a temperature in which bioink For printing the vascular system undergoes melt, removing the bioink, optionally, causing growth in the channel by means oF cells in a medium, wherein, the cross-section oF the channel being the same as the cross-section oF native vessels present in a living organism. The inventions relates to a bionic model with a perFusable system.
Absstract of: US2025195144A1
A system for mixed reality surgical simulation is provided. The system includes a simulator, an optical tracking system, an input device, a visualization screen, and a simulation workstation, wherein the simulation workstation renders an augmented view on the visualization screen.
Absstract of: US2025196403A1
A photocurable composition, contains a (meth)acrylic monomer component, and photopolymerization initiator, in a case in which a rectangular sheet-like test piece A1 with a length of 40 mm, a width of 10 mm, and a thickness of 1.0 mm is produced by photomodeling under conditions in which the photocurable composition is irradiated with visible light having a wavelength of 405 nm at an irradiation dose of 11 mJ/cm2 to form a cured layer A1 with a thickness of 50 μm, the cured layer A1 is stacked in a thickness direction thereof to form a rectangular sheet-like modeling product A1 with a length of 40 mm, a width of 10 mm, and a thickness of 1.0 mm, and the modeling product A1 is irradiated with ultraviolet rays having a wavelength of 365 nm at an irradiation dose of 3 J/cm2 to produce the test piece A1.
Absstract of: US2025195191A1
The present disclosure provides an apparatus for post-curing an article, as well as a system, methods, and post-cured articles. The apparatus includes a housing, a chamber disposed in the housing, at least two light emitting diodes (LEDs) disposed within the housing, and a user interface disposed on an exterior of the housing. The chamber is adaptable to each of an open, closed, and hermetically sealed configuration. The chamber includes a material transparent to actinic radiation and light from the LEDs enters the chamber from more than one direction. The user interface includes a display and program switches configured to adjust at least three operational parameters of the apparatus. The apparatus further includes a vacuum pump operatively coupled to the chamber. The system includes the apparatus and an article. An article includes layers of at least one photopolymerized crosslinked composition and a low extractable component content. A method of post-curing an article includes obtaining an article, placing the article in an apparatus, inputting a post-cure program or accessing a saved post-cure program through the user interface, and running the post-cure program. The post-cure program includes light intensity provided by a light source and length of time of light provided by the light source, plus a delay time between initiation of light provided by the light source and initiation of vacuum pulled by the vacuum pump and/or a delay time between initiation of vacuum pulled
Absstract of: US2025195179A1
There is described a medical implant comprising: a bone engaging portion comprising: an outer portion comprising or consisting of a conformal lattice structure; an inner portion comprising a cavity or a lattice structure; a helical thread extending around and recessed into or protruding from an outer surface of said bone engaging portion, said helical thread being configured to facilitate screwing of said bone engaging portion into bone.
Absstract of: US2025195208A1
The invention relates to an ear implant for improving or restoring the hearing ability in the event of defects in the area of the ossicles of the ear or posterior wall of the auditory canal, said implant consisting of lithium disilicate glass ceramic having a molar ratio of SiO2 to Li2O of 2 to 3, wherein the glass ceramic material being doped and stabilized with P2O5 and ZrO2, as well as a method for the production of the implant and the use of lithium disilicate glass ceramics in ear implants.
Absstract of: US2025195099A1
The invention relates to a method of manufacturing an inner tube for a surgical cutting device comprisinga. an outer tube having an outer tube head portion at a distal end of the outer tube;b. said outer tube head portion having an outer tube window; whereinc. the inner tube can be rotatably disposed in the outer tube;d. an inner tube head portion is provided at a distal end of the inner tube; whereine. at least one cutting edge is formed on the inner tube head portion, which cutting edge is moved out of an interior of the outer tube when the inner tube is rotated through the outer tube window and is moved back into the interior of the outer tube when the inner tube is further rotated through the outer tube window; the method comprising the following steps:f. providing an inner tube middle portion having a distal end;g. forming the inner tube head portion at the distal end of the inner tube middle portion by an additive manufacturing process to obtain the inner tube.
Absstract of: US2025196517A1
The present invention provides a printing mechanism for a medical monitoring device and a medical monitoring device. The printing mechanism comprises a movable frame assembly comprising a frame and a print paper drawer for holding the print papers, the print paper drawer being mounted on the frame to move along with the movable frame assembly, wherein a front end wall of the print paper drawer is formed as a curved wall comprising a first portion extending perpendicularly from a front end of a bottom plate of the print paper drawer and a second portion extending from the first portion and bending towards a rear end of the print paper drawer with respect to the first portion, and the second portion forms an anti-tilting surface for preventing the print papers from tilting. According to the printing mechanism for the medical monitoring device of the present invention, the end of the print papers contacting the anti-tilting surface does not slip and tilt during printing while the smoothness in feeding the print paper to the printing head is not affected.
Absstract of: AU2023323651A1
Provided is an implantable tissue scaffold comprising a mixture of a biocompatible organic polymer and chitin, wherein the chitin is embedded in the biocompatible organic polymer. Also provided is a composition for 3D printing, the composition comprising at least one biocompatible organic polymer and chitin that may be partially deacetylated, wherein the chitin is embedded within the biocompatible organic polymer. Further provided is a method of promoting tissue formation, comprising implanting a tissue scaffold comprising a mixture of a biocompatible organic polymer and chitin at a site in need of regenerative bone tissue formation.
Nº publicación: EP4568614A1 18/06/2025
Applicant:
ZARRINPOUR ARASH [FR]
BERGEYRON PATRICE [CH]
Zarrinpour, Arash,
Bergeyron, Patrice
Absstract of: WO2024033402A1
The invention relates to a maxillary modeller (2) intended to be worn, in a service position, on a dental arch of a user in order to modify the shape of the palate, the maxillary modeller being one-piece and removable and comprising: - a central palatal portion (22) configured to be in contact with the user's palate when the maxillary modeller is in the service position; and - a first and a second dental portion (24; 26) each comprising at least one, preferably multiple cavities configured to receive teeth of the user when the maxillary modeller is in the service position, the first and second dental portions extending on either side of the central palatal portion, the central palatal portion being configured so as to exert on the palate, in the service position, forces suitable for modifying the shape thereof.
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