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166
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Updated on
21/02/2026 [07:21:00]
Results 150 to 166 of 166
Absstract of: CN121371168A
本发明提供一种复合支架材料及其制备方法与应用，涉及复合材料技术领域，制备方法包括：将六水合氯化铁、无水乙酸钠加入乙二醇中反应，得到Fe3O4纳米颗粒；将铁氰化钾、分散介质加入盐酸溶液中溶解，再加入Fe3O4纳米颗粒反应，得到Fe3O4/PB异质结；将Fe3O4/PB异质结与左旋聚乳酸混合研磨，通过激光打印形成PLLA‑Fe3O4/PB微波抗菌复合支架材料，本发明以PLLA为载体，负载Fe3O4/PB异质结构建支架材料，通过磁‑介协同效应增强微波吸收性能，在微波照射下，借助界面极化与偶极子极化双重机制，同步实现微波热疗与微波动力，二者协同对金黄色葡萄球菌感染的骨髓炎展现出高效抗菌效果。
Absstract of: CN121371305A
本发明公开了一种采用双重冷萃冻干工艺制备的颅骨组织工程支架及其制备方法，本发明首次创造性地提出引入“双重冷萃冻干工艺”，以实现“打印‑干燥‑交联‑再干燥”的温和处理过程，在保留支架形貌精度的同时，显著增强其力学性能与结构稳定性，为3D打印骨组织工程材料的临床转化提供了全新思路与技术支撑，在临床骨修复领域具有广阔的应用前景。
Absstract of: CN121370368A
本发明涉及一种基于云模式的脑出血穿刺手术区域协同方法、系统及介质，涉及医疗手术区域协同技术领域。第一服务终端响应于获取的需要实施脑出血穿刺手术患者的脑出血穿刺手术信息，生成脑出血穿刺手术协同请求并发送至第二服务终端，第二服务终端响应于收到的脑出血穿刺手术协同请求确认是否同意协同的指令，若是同意协同的指令，则向第一服务终端发送同意协同的反馈，第一服务终端响应于收到的同意协同的反馈，向第二服务终端发送确认信息；第二服务终端响应于第一服务终端的确认信息，制定脑出血穿刺手术协同方案，制作脑出血穿刺手术3D打印导板。该方案，可以在患者不需要转院的情况下，及时提供可靠性更高的脑出血穿刺手术，促进便民医疗。
Absstract of: CN121371323A
本发明公开了一种基于羟基磷灰石、氧化镁和单宁酸的多孔复合材料的制备方法，该方法以聚乙二醇二丙烯酸酯为光交联单体，二苯基（2，4，6‑三甲基苯甲酰基）氧化膦为光引发剂，通过将纳米羟基磷灰石、纳米氧化镁和单宁酸均匀分散于单体溶液中，形成光固化浆料，并在紫外光下通过光固化3D打印技术成形。其中，纳米羟基磷灰石提供骨传导性，纳米氧化镁释放镁离子以促进成骨细胞分化，单宁酸赋予材料抗菌抗炎性能；采用三周期极小曲面中的Gyroid结构作为支架结构，该结构结合各组分的功能协同作用，使制备出的复合材料骨支架同时具备高孔隙率、优良的抗压强度、显著的生物活性以及主动的抗菌抗炎能力，能够有效促进骨组织的修复与再生。
Absstract of: CN121371309A
本发明涉及生物医用材料与再生医学技术领域，尤其是一种基于胶原纤维‑羟基磷灰石合成的复合弹性支架及其制备方法、应用。所述的复合弹性支架由胶原蛋白与羟基磷灰石复合形成，胶原蛋白自组装形成胶原纤维网络，羟基磷灰石在胶原纤维网络中均匀分散；其制备方法如下：将酸性胶原溶液和羟基磷灰石悬浮液混合形成打印墨水，经超声与低速离心除泡后在卡波普支撑浴中进行三维打印→温控孵育形成胶原纤维网络结构→含盐缓冲液洗除支撑浴→交联处理→冷冻干燥得到多孔弹性支架。本发明表现出弹性结构特征、可观察的血液吸收及因子凝集行为，并在动物骨‑软骨缺损模型中显示出良好的修复能力及生物相容性，用于骨软骨损伤修复等组织工程领域。
Absstract of: CN121370444A
本发明涉及一种增材制造的空心股骨髁假体及其制作方法，属于人工膝关节假体技术领域。本发明的空心股骨髁假体包括股骨髁本体、堵销及可选的多孔结构。股骨髁本体设有连通的空腔，空腔可配置加强筋以增强刚性。假体内型面（如前髁面、远端截骨面等）用于与股骨远端截骨面匹配定位，外型面（如外侧髁、内侧髁）与胫骨垫和髌骨形成关节面。非骨水泥型假体设有多孔结构，其厚度为0.6‑2mm，用于骨长入生物固定；骨水泥型假体设有骨水泥凹槽用于术中固定。假体关节面采用高抛光氧化锆涂层（粗糙度低于Ra0.05），有效降低磨损。假体采用钛合金或钴铬钼合金通过激光增材制造一体成型，确保精度和强度，提升制造效率。
Absstract of: US20260021487A1
A novel portable, and attachable device allows precise positioning of micro-tissues, tumor spheroids, and other biological samples during bioprinting. The device features an interchangeable connector for handling samples of various sizes and uses a manually adjustable pressure system for suction and deposition. A programmable control unit coordinates pressure and positioning based on input commands, enhancing accuracy and consistency in tissue handling. Compatible with multiple bioprinter systems and supporting both manual and automated operation, it streamlines workflows and improves user experience. This device addresses challenges in high-throughput biological positioning, critical for tissue engineering, clinical, pharmaceutical, and research applications. It supports advancements in customized medicine, biological models, and environmental monitoring, meeting the growing demand for precise biologic handling in the multi-billion-dollar bioprinting and biopsy markets. The device offers superior control over tissue biopsy positioning compared to current manual devices reliant on operator skill.
Absstract of: US20260020643A1
A device and method for the formation of customized footwear insoles and pads is provided. The system employs computers operatively engaged to scanning components to produce individual electronic footprints of a foot of a wearer. Software operating to the tasks of employing the digital data from one or a plurality of electronic footprints, correlating to scans of the feet of a footwear user, will customize an insole or pad for positioning in the footwear to more comfortably support the foot therein.
Absstract of: US20260020865A1
A low-cost disposable. 3-D printed cutting guide. The cutting guide may be made with modular attachment spikes. The cutting guide may be provided in connection with a femoral trial for use in preparing a patient's bone to receive an implant.
Absstract of: US20260020978A1
The present invention relates to a system (1) adapted for providing a thermal and therapeutical effect to a patient (10) at a specific point of his body. The system comprises an element of contact (20a, 20b), adapted to be placed in contact to the point of body. The element of contact comprises a structural element (21) defining a tridimensionality shape. The system also comprises a thermal regulation device (50) and a regulation fluid circulating through the thermal regulation device and the element of contact. The present invention also relates to a process adapted to manufacture such a structural element.
Absstract of: US20260021222A1
A biological 3D printed multilayered scaffold is provided, which comprises a crosslinked native or non-modified protein containing a di-tyrosine matrix: the scaffold being configured for containing living cells introduced thereto during printing or post-printing.
Absstract of: US20260022324A1
A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
Absstract of: US20260021632A1
The invention generally relates to microneedle devices, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disease comprising administering same. Specifically, the disclosed microneedle devices comprise a plurality of biocompatible microneedles having one or more of: (i) a curved, discontinuous, undercut, and/or perforated sidewall; (ii) a sidewall comprising a breakable support; and (iii) a cross-section that is non-circular and non-polygonal. The microneedles may also be tiered. Alternatively, the microneedles may be tiered. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Absstract of: US20260022330A1
A composition which is a hydrogel including, in an aqueous medium: at least one hydrophilic thickening polymer, and particles of eggshell membrane, in an amount of less than 5% by weight of the total weight of the composition, wherein the particles are rod-shaped, needle-shaped or fibrous, having a specific particle size. Also described is a bioink including the composition, a method for manufacturing a 2D or 3D product using the hydrogel, a kit including the hydrogel or bioink, and to uses thereof.
Absstract of: AU2025287348A1
Creating a replica of an anatomical structure. In one embodiments a method includes: accepting pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure to create a positive model; creating a negative model from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice, thereby creating a final negative model; placing a zeroing and angling object to align the negative model to a predetermined angle; placing a base tool object by coupling the base tool object to the outside surface; and casting the replica of the anatomical structure using the negative mold. ec e c
Nº publicación: US20260020963A1 22/01/2026
Applicant:
HOWMEDICA OSTEONICS CORP [US]
Howmedica Osteonics Corp
Absstract of: US20260020963A1
An implant having two adjacent solid parts, a third solid part disposed between the two solid parts, and a porous part extending from the solid parts. The implant is fabricated by a process that includes first assembling the solid parts before additively manufacturing the porous part on surfaces defined by the solid parts. This process may include positioning a first fabricated component adjacent to a second fabricated component such that a side surface of the first fabricated component and a side surface of the second fabricated component form a build surface. Then additively manufacturing a structure on the build surface such that the structure extends across and is permanently fixed to both of the side surfaces of the first and the second fabricated components such that the first and the second fabricated components form part of the implant.
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