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69
results.
Updated on
05/04/2026 [08:03:00]
Results 50 to 69 of 69
Absstract of: KR20250177874A
본 발명은 서열번호 1의 올리고뉴클레오티드 프라이머 및 서열번호 2의 올리고뉴클레오티드 프라이머를 포함하는, 리스테리아 모노사이토제네스(Listeria monocytogenes) 검출용 프라이머 세트; 이를 포함하는 조성물; 이를 포함하는 키트; 및 이를 이용한 리스테리아 모노사이토제네스(Listeria monocytogenes) 검출 방법에 관한 것이다.
Absstract of: CN121182992A
The invention relates to the technical field of biological detection, and discloses a composition for detecting respiratory tract infection pathogens, a kit and application. The composition disclosed by the invention can be used for rapidly and simultaneously detecting legionella pneumophila, bordetella pertussis, chlamydia pneumoniae, mycoplasma pneumoniae, mycobacterium tuberculosis, aspergillus and cryptococcus neoformans in a sample with high specificity, and has relatively high sensitivity and stability. Compared with traditional detection methods such as pathogen isolated culture and genome sequencing, the efficiency of identifying and jointly detecting multiple respiratory tract pathogens by adopting the composition disclosed by the invention is effectively improved, the detection process is simple and convenient to operate, and the composition is suitable for large-scale popularization and application.
Absstract of: CN121182993A
The invention discloses a primer group for simultaneously detecting four pathogenic microorganisms and application of the primer group in preparation of a micro-fluidic chip and a kit. The sequences of the primers are as shown in SEQ ID NO: 1-24. The method has the advantages that the microfluidic technology and the isothermal amplification technology are combined, four sample indexes are detected at the same time in one-time detection, and the method has the advantages of being high in throughput, high in specificity, good in experiment repeatability and convenient and rapid to operate; the kit can be used for rapidly and accurately detecting salmonella (SAL), staphylococcus aureus (SA), listeria monocytogenes (LM) and escherichia coli O157: H7 (E. coli O157: H7).
Absstract of: CN121160893A
The invention discloses a multiplex fluorescent quantitative PCR (polymerase chain reaction) detection kit for prawn culture pathogenic bacteria, which is characterized in that the kit contains primers and probes for detecting the prawn culture pathogenic bacteria, wherein the primers and the probes are respectively used for detecting TDH-related hemolsin genes of vibrio parahaemolyticus, ORF107 genes of white spot syndrome viruses, small subunit ribosomal genes of shrimp enterocytozoon hepatopenaei, 37 kDa coat protein genes of infectious subcutaneous and hematopoietic necrosis viruses, DNA (deoxyribonucleic acid) primer genes of full-eye iridovirus 1 and PirA pi genes of pathogens of bacterial prawns acute hepatopancreas necrosis; the method has the advantage that the detection of eight prawn culture pathogens can be realized at the same time. The method comprises the following steps of: obtaining a tcdB gene of a high-pathogenicity vibrio and a hemolsin gene of a vibrio harveyi;
Absstract of: CN121160897A
The invention discloses a rapid PCR (polymerase chain reaction) detection method and kit for klebsiella pneumoniae, acinetobacter baumannii and pseudomonas aeruginosa, and belongs to the technical field of microbiological detection. The kit comprises a primer probe combination which is specifically designed for an rpsD gene of klebsiella pneumoniae, an acinetobacter baumannii recA gene and a pseudomonas aeruginosa ecfx gene, and the combined probe is subjected to Spacer linker blocking modification, so that the detection specificity of a system is remarkably improved. The method is simple, convenient and rapid to operate, the detection sensitivity of the klebsiella pneumoniae, the acinetobacter baumannii and the pseudomonas aeruginosa can reach 0.5 copies/mu L, the specificity is good, and an effective tool is provided for early and rapid diagnosis of lower respiratory tract infection caused by the klebsiella pneumoniae, the acinetobacter baumannii and the pseudomonas aeruginosa clinically.
Absstract of: WO2025255902A1
A primer and probe for detecting Salmonella pullorum, and a kit. The primer comprises SP-F and SP-R for detecting the target sequence of the Salmonella pullorum (SP) citE2 gene, and the probe is modified with a fluorescent reporter group and a fluorescent quenching group. By means of providing the primer pair of SP-F and SP-R, which pair specifically binds to the target sequence of the citE2 gene, and combining the primer pair with the probe, whic is used for specific recognition, the accurate and sensitive detection of Salmonella pullorum can be realized.
Absstract of: WO2025256021A1
A Pseudomonas aeruginosa InA protein and a use thereof, relating to the technical field of biological detection. The InA protein is InAS2, InAAP41, or InAS8, the amino acid sequences of which are respectively as shown in SEQ ID NOs: 1-3; and nucleotide sequences encoding InAS2, InAAP41, and InAS8 are as shown in SEQ ID NOs: 4-6. Compared with the prior art, the InA protein can improve the solubility of a target protein. In addition, there is also an ultra-high affinity between the InA protein and a Pseudomonas aeruginosa immune protein, and on this basis, a reversible and regenerable biosensing chip is developed. The chip can capture a fusion protein carrying the InA protein and can be used for detecting the affinity between the fusion protein carrying an InA tag and a candidate drug, thereby achieving drug screening. Moreover, the protein-drug affinity kinetics detected by the chip can also be used in drug pharmacology research.
Absstract of: CN121142033A
The invention provides a graphene electrode for detecting food-borne pathogenic bacteria, a sensor and application, and belongs to the technical field of analysis of electrochemical sensing. A defect-rich graphene conductive layer is created on the surface of a porous polymer membrane through laser irradiation, then carboxyl-rich magnetic nanoparticles are modified into recognition elements (immunomagnetic beads and IMBs) for capturing and enriching target bacteria in a sample, uncombined free IMBs are separated through nano-filtration of a membrane chip, and the target bacteria in the sample are detected. The larger IMBs-bacterial compound is retained, and the IMBs-bacterial compound retained on the LIG layer confinement structure generates impedance signal change in the micro-electrochemical cell, so that bacterial detection is realized. Meanwhile, the PES-LIG electrode provided by the invention can highly sensitively identify trace target bacteria in a complex matrix.
Absstract of: CN121135871A
The invention relates to a porcine delta coronavirus N protein monoclonal antibody as well as a fluorescence immunochromatography detection kit and application thereof. According to the application, a prokaryotic expression system is utilized to express the N protein in escherichia coli, the purified N protein is taken as an immunogen, a BALB/c mouse is immunized by an immunological method to prepare the anti-PDCoV N protein monoclonal antibody with high affinity and high potency, and the antibody can be applied to preparation of a PDCoV detection reagent or vaccine. Meanwhile, the invention provides a PDCoV antibody detection kit, N protein and quantum dots (QDs) are subjected to covalent coupling through an EDC method, a fluorescent probe (QDs-Ag) is synthesized, and PDCoV antibody detection is conducted on test paper sprayed with a T line (SPA) and a C line (mAb). The specificity is good, the sensitivity is high, and convenience and accuracy are both considered.
Absstract of: CN121142040A
The invention provides a kit for rapidly detecting five calf diarrhea related pathogenic microorganisms, which comprises a colloidal gold test strip for ELISA (enzyme-linked immuno sorbent assay) antigen detection, and a monoclonal antibody is dotted on the test strip. Wherein the monoclonal antibody is prepared by immunizing mice with antigen proteins of bovine rotavirus, bovine coronavirus, escherichia coli, cryptosporidium and clostridium perfringens. The kit for rapidly detecting five pathogenic microorganisms related to calf diarrhea provided by the invention has high detection accuracy, can simultaneously detect five pathogenic microorganisms causing calf diarrhea, and does not cause pathogenic microorganism pollution and affect biological safety. And field operation can be performed, detection is performed immediately after sampling, and a result is given in a relatively short time. The kit disclosed by the invention is simple in detection operation and low in requirements on personnel and equipment.
Absstract of: CN121137198A
The invention provides a primer probe combination for detecting respiratory tract pathogenic bacteria. The primer probe combination comprises a primer probe combination for detecting klebsiella pneumoniae, a primer probe combination for detecting staphylococcus aureus, a primer probe combination for detecting pseudomonas aeruginosa and a primer probe combination for detecting escherichia coli. The invention also provides a method for detecting respiratory tract pathogenic bacteria by using the primer probe combination. The method comprises the following steps: extracting DNA of a respiratory tract sample; respectively carrying out micro-droplet generation, PCR (Polymerase Chain Reaction) amplification and micro-droplet detection on the extracted respiratory tract sample DNA by using the primer probe combination for detecting the respiratory tract pathogenic bacteria; and interpreting the result. By optimizing the primer design and the PCR amplification system, the kit has the advantages of high specificity, high sensitivity, wide detection range and the like, is rapid and accurate in detection, does not need microbiological culture bacterium expansion on a sample, and is simple and convenient to operate, high in detection flux and short in whole-process detection time.
Absstract of: CN121137253A
The invention belongs to the technical field of plant fungus molecular biology detection, and discloses an LAMP primer group, a kit and a detection method for detecting oat smut pathogenic bacteria. A group of LAMP (loop-mediated isothermal amplification) specific primers are designed according to a specific sequence on a whole genome of the oat smut pathogenic bacteria Ustilago hordei, results are judged through a real-time fluorescence quantification method, an agarose gel electrophoresis method and an SYBR Green I fluorescent dye developing method, and the oat smut pathogenic bacteria carried by oat seeds are detected. The LAMP detection method for the oat smut pathogenic bacteria, established by the invention, is strong in specificity, high in sensitivity, high in speed and low in cost, provides a new technical means for detection of the oat smut pathogenic bacteria carried by the oat seeds, and has relatively high practical application value.
Absstract of: CN121135834A
The invention discloses a pseudomonas aeruginosa InA protein and application thereof, and relates to the technical field of biological detection, the InA protein is InAS2, InAAP41 or InAS8, the amino acid sequences of the InA protein are respectively shown as SEQ ID NO.1-3, and the nucleotide sequences for coding the InAS2, the InAAP41 and the InAS8 are shown as SEQ ID NO.4-6. Compared with the prior art, the InA protein can improve the solubility of target protein, in addition, the InA protein and pseudomonas aeruginosa immune protein also have ultrahigh affinity, a biosensing chip with regeneration reversibility is developed based on the InA protein, the chip can capture fusion protein with the InA protein, and the biosensing chip has the advantages that the biosensing chip can be used as a biosensing chip with regeneration reversibility, so that the biosensing chip can be applied to biosensing of pseudomonas aeruginosa. The chip can be used for detecting the affinity between the fusion protein with the InA tag and a candidate drug, drug screening is realized, and meanwhile, the protein-drug affinity kinetics detected by the chip can also be used for pharmacological research of drugs.
Absstract of: CN121142029A
The invention belongs to the technical field of biological detection, and discloses a rapid immunochromatography detection kit for gastrointestinal pathogenic bacteria based on a viral nano-enzyme probe. The invention discloses a nano-enzyme probe, the virus-shaped nano-enzyme probe provided by the invention takes Fe3O4 nano-particles as a core, Pt nano-particles and Au (at) Pt nano-particles are coated in sequence, a specific antibody is modified, and the nano-enzyme probe has a magnetic enrichment effect and a multi-catalytic-site characteristic at the same time; rapid capture and high-sensitivity quantitative detection of various gastrointestinal pathogenic bacteria in complex matrixes (river water samples, lake water samples and excrement samples) can be realized, and matrix interference in practical application is eliminated; and the kit has huge potential in the aspects of high-sensitivity field screening and clinical monitoring of infection of gastrointestinal bacteria (such as escherichia coli, salmonella and helicobacter pylori).
Absstract of: CN121122425A
The invention discloses a rapid detection method for bloodstream infection pathogenic bacteria based on a rapid mass spectrometry technology, and belongs to the technical field of medical detection. Analyzing the metabolic gas of the blood flow infected pathogenic bacteria by using UVP-TOFMS to obtain a pathogenic bacteria metabolic profile spectrogram; preprocessing the obtained pathogenic bacterium metabolism profile spectrogram data; integrating the preprocessed pathogenic bacterium metabolism profile spectrogram data by using a stacking algorithm, and constructing a pathogenic bacterium identification model; evaluating the effectiveness of the pathogenic bacterium identification model on a training set and a test set through accuracy, precision, a confusion matrix and a subject operation curve; and comparing and screening characteristic metabolic markers of the pathogenic bacteria by combining the importance and significance of model characteristics, and indicating the types of the pathogenic bacteria. The method does not need sample pretreatment, is simple and convenient to operate, short in detection time (20 seconds per sample), high in accuracy and suitable for clinical popularization, and provides technical support for early diagnosis and treatment of bloodstream infection.
Absstract of: CN121109656A
The invention belongs to the technical field of microbiological detection, and particularly relates to a method for rapidly detecting viable salmonella and application. The method comprises the following steps: mixing a sample to be detected with Felix O-1 bacteriophage, incubating at 37 DEG C to enable the Felix O-1 bacteriophage to infect and proliferate in the sample to be detected, and performing splitting decomposition treatment after infection proliferation is finished to obtain proliferated Felix O-1 bacteriophage DNA (Deoxyribose Nucleic Acid); felix O-1 bacteriophage DNA is used as a template for real-time fluorescence RPA amplification, and whether viable salmonella exists or not is judged through fluorescence signal intensity. According to the method provided by the invention, the defects that the traditional bacterial culture and biochemical confirmation method is long in time consumption and the original molecular biological method cannot conveniently distinguish dead and live are overcome. The method is short in detection time, the RPA reaction is carried out under a constant-temperature condition, equipment requirements are simple, and the method is suitable for field detection.
Absstract of: CN121109619A
The invention discloses a listeria monocytogenes detection system based on a split G-quadruplex cascade CRISPR/Cas12a system and application of the listeria monocytogenes detection system, and belongs to the technical field of food safety detection. According to the detection method, a split G quadruplex probe is applied, and the split G quadruplex probe is composed of three incomplete guanine-rich DNA chains, namely a G-a chain, a G-b chain and a Linker chain. When no target exists, the CRISPR/Cas12a system is not activated, the Linker chain is complete, and a complete G quadruplex is assembled to be combined with the fluorescent dye to emit fluorescence; when a target exists, an RPA amplification product activation system reversely cuts a Linker chain, a split-chain G quadruplex fails to assemble, ThT cannot be embedded, a fluorescence signal is remarkably reduced, the split G quadruplex is used for replacing a traditional fluorescence modified probe, the method has the advantages of being low in cost, high in sensitivity, high in specificity and the like, and a novel technical platform is provided for detecting listeria monocytogenes in food.
Absstract of: CN121109557A
The invention belongs to the technical field of food safety detection, and relates to a method for simultaneously extracting and detecting nucleic acid of listeria monocytogenes and salmonella. The method comprises the following steps: cracking listeria monocytogenes and salmonella by using a bacterial lysis solution and releasing nucleic acid of listeria monocytogenes and salmonella; the nucleic acid of the listeria monocytogenes and the nucleic acid of the salmonella are extracted at the same time through the synthesized magnetic beads Fe3O4 and Al < 3 + >, and the nucleic acid of the listeria monocytogenes and the nucleic acid of the salmonella are detected at the same time through double RPA/RT-RPA and RPA-LFA test paper. The method has the characteristics of rapidness, high sensitivity and low equipment requirement, and has practical application value in on-site instant detection of food safety.
Nº publicación: CN121086037A 09/12/2025
Applicant:
ZHEJIANG ZHENYUAN PHARMACEUTICAL CO LTD
UNIV ZHEJIANG TECHNOLOGY
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Absstract of: CN121086037A
The invention provides a receptor binding protein for beta-lactam antibiotic detection. According to the present invention, efficient soluble expression is performed on the blaRCT gene derived from Bacillus licheniformis in Escherichia coli, such that the receptor binding protein blaRCT capable of being used for beta-lactam antibiotic detection is obtained; detection results show that the receptor binding protein blaRCT has very high affinity and sensitivity to various beta-lactam antibiotics, and the stability of the receptor binding protein blaRCT is still kept above 80% after the receptor binding protein blaRCT is placed at 4 DEG C for half a year. The receptor binding protein has the advantages of high affinity, high sensitivity and high stability, and lays a foundation for subsequent research of beta-lactam antibiotic receptor binding proteins.
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