Alerta

CONTROL SYSTEM FOR BLOOD GLUCOSE MONITORING AND MANAGEMENT

Absstract of: EP4782028A1

The invention discloses a control system for blood glucose monitoring and management. The first working mode of the control system is configured to control the blood glucose monitoring device to perform real-time blood glucose monitoring, and the system enters the second working mode based on a trigger. The second working mode at least is configured to control the blood glucose monitoring device to perform real-time blood glucose monitoring and to control the insulin infusion device to perform insulin infusion. By the trigger, the control system transitions from the first working mode of real-time blood glucose monitoring by controlling the blood glucose monitoring device to the second working mode of at least real-time blood glucose monitoring by controlling the blood glucose monitoring device and insulin infusion by controlling the insulin infusion device, preventing patients from accidentally entering unnecessary or unacceptable working mode and improving the safety of blood glucose monitoring and management for patients.

METHOD TO AVOID HYPOGLYCEMIA BY MINIMIZING LATE POST-PRANDIAL INSULIN INFUSION IN AID SYSTEM

Absstract of: US2025090754A1

0000 Embodiments can relate to an insulin delivery controller which implements a processor configuration to efficiently attain an insulin delivery target. The insulin delivery controller can include a processor and a memory associated with the processor. The processor can process glucose data received from the memory, including a data representation of glycemic disturbance (d(t)). The processor can determine a glucose rate of change (G′(t)). The processor can generate a command signal to dynamically reshape a glycemic disturbance within a prediction horizon of the insulin delivery controller according to the G′(t). The processor can generate an insulin command signal for an insulin delivery unit to adjust an insulin delivery dosage amount and/or an insulin delivery dosage rate.

MEDICAL DEVICE ALERT, OPTIMIZATION, PERSONALIZATION, AND ESCALATION

Absstract of: EP4783190A2

An alert is used to inform a user that their blood glucose level has dropped below a threshold (e.g., the user is hypoglycemic) or has increased above a threshold (e.g., the user is hyperglycemic). There is a hierarchy of alerts from lowest priority to highest priority. The alert is communicated by a user device (e.g., a mobile device), which is, for example, a smartphone, smart watch, home automation device, or the like. The alert is modified in order to increase the likelihood that the user receives or acknowledges the alert within a minimal amount of time. An intensity level (e.g., a volume) of an alert is modified based on, for example, whether the user has acknowledged a previous alert. A modality or a sensory channel of an alert is changed if an initial alert does fails to elicit a response from the user.

CLOSED-LOOP ARTIFICIAL PANCREAS SYSTEM

Absstract of: EP4782029A1

0001 The invention discloses a closed-loop artificial pancreas system, comprising: a detection mechanism, an infusion mechanism, and a program mechanism, at least based on the blood glucose value detected by the detection mechanism, the program mechanism generates an insulin infusion instruction and controls the infusion mechanism to perform the infusion, the system adopts an infusion strategy consisting of pre-infusion and supplemental infusion, and an amount of insulin for pre-infusion is related to an estimated meal size at a time of pre-infusion, an amount of insulin for supplemental infusion is related to an estimated meal size at a time of supplemental infusion. There is no need to explicitly determine the size of the meal, and the system determines the amount of insulin to be infused based on the size of the predicted meal, on the one hand, relieving the pressure to accurately determine the size of the meal, and at the same time, taking into account the dynamic impact on blood glucose levels after the meal and the interactive effects of the bolus itself. The system adopts the infusion strategy consisting of pre-infusion and supplemental infusion, maintaining the patient's glucose concentration at a desirable level.

A METHOD OF PREPARATION OF 13C LABELED BIOMOLECULES

Absstract of: EP4782547A1

The present invention provides a method for preparation of fully ¹³C isotopically labeled biomolecules or biomolecules having a predetermined ¹³C isotopic labeling by biosynthesis in a mammalian cell line, which comprises the following steps:a) providing a mammalian cell line capable of growing in serum-free media;b) culturing the cell line obtained in step b) in a serum-free medium containing: fully ¹³C isotopically labeled amino acids or ¹³C isotopically labeled amino acids, fully ¹³C isotopically labeled glucose and/or fully ¹³C isotopically labeled galactose, or ¹³C isotopically labeled glucose and/or ¹³C isotopically labeled galactose, fully ¹³C isotopically labeled choline or ¹³C isotopically labeled choline, vitamins, distilled water, insulin, transferrin, sodium selenite, and inorganic salts wherein when the inorganic salt contains carbon, it is preferably fully ¹³C isotopically labeled;c) obtaining ¹³C isotopically labeled biomolecules from the cells or medium after the cultivation of step b).The resulting biomolecules and their mixtures are suitable for use as internal standards in metabolomics and fluxonics, as well as in biotechnological research as standards or markers.

GAMMA DELTA T CELL TARGETING PD-L1, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Absstract of: EP4782536A1

Provided are a γδT cell targeting PD-L1, and a preparation method therefor and the use thereof. By means of unnatural sugar metabolic labeling, the γδT cell is modified with a first active group, and then same and a PD-L1 targeting group modified with a second active group are subjected to a bioorthogonal reaction, thereby obtaining the γδT cell targeting PD-L1. The γδT cell targeting PD-L1 has a targeted and selective killing effect on PD-L1-positive tumor cells; has the advantages of a short preparation cycle, suitability for large-scale production, uniform and stable quality, etc.; and has good application prospects.

IMPLANTABLE SENSOR DEVICES, SYSTEMS, AND METHODS

Absstract of: EP4781911A2

0001 Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition. For example, after implantation of a sensor, a physiological response may occur at some time after implantation. The sensor can be used to measure one or more properties of biological tissues surrounding the implant 100, the one or more measured parameters can be processed 102, and such measurements can subsequently be used to identify a physiological condition or response of the body or a sensor failure at 104, to determine a quality score 106, and to determine a proper response to a particular condition or quality score 108.

Neural function recovery evaluation method based on microcirculation-autonomic nerve-temperature coupling

Absstract of: CN122460901A

The invention discloses a nerve function recovery evaluation method based on microcirculation-autonomic nerve-temperature coupling, and belongs to the field of digital medical treatment and endocrine pharmacology. The system comprises: a microcirculation perfusion analysis module (L23) for calculating a microcirculation perfusion index (MPI) based on a multi-wavelength PPG signal; an autonomic nerve analysis module (L24) that calculates an autonomic nerve function index (ANFI) based on the heart rate variability; a temperature regulation analysis module (L25) that calculates a core-peripheral temperature difference (Delta T) based on the core temperature and the peripheral temperature; a coupled evaluation module (L26) to calculate a neural function recovery index (NFRI) based on MPI, ANFI, and DeltaT; and the curative effect evaluation module judges the drug effect based on the NFRI change before and after treatment. Objective quantitative evaluation of the diabetic neuropathy drug neural restoration effect is realized, and an objective tool is provided for early diagnosis and curative effect monitoring.

Metformin-induced stem cell-derived extracellular matrix material as well as preparation method and application thereof

Absstract of: CN122461574A

The invention discloses a metformin-induced stem cell-derived extracellular matrix material as well as a preparation method and application thereof, and relates to the technical field of biological materials. The preparation method comprises the following steps: inoculating mesenchymal stem cells on a pretreatment culture carrier, and carrying out induction treatment on the mesenchymal stem cells by adopting a culture system containing metformin; ascorbic acid is added for extracellular matrix secretion induction culture; carrying out decellularization treatment and nuclease treatment on the extracellular matrix induced by the metformin; collecting the stem cell-derived extracellular matrix induced by metformin, mixing the stem cell-derived extracellular matrix with an aqueous medium, and performing centrifugal treatment and enrichment to form extracellular matrix precipitate; the extracellular matrix precipitate is subjected to freezing treatment and unfreezing treatment in sequence, and the extracellular matrix material with the metformin-induced stem cell source is obtained. Metformin is used for inducing mesenchymal stem cells to secrete the engineered extracellular matrix, and the engineered extracellular matrix is used for promoting repair of bone defects, skeletal muscle injuries and muscle-bone joint defects in a diabetic environment.

Cleaning perfusate for cerebrospinal cord operation and preparation method of cleaning perfusate

Absstract of: CN122461335A

The invention relates to the technical field of preparation of pharmaceutical preparations, and particularly discloses washing perfusate for cerebrospinal cord surgery and a preparation method of the washing perfusate. The preparation method of the washing perfusate for cerebrospinal cord surgery comprises the following steps: mixing glucose, sodium chloride, calcium chloride, magnesium chloride and water for injection to obtain a solution A; mixing sodium bicarbonate, sodium chloride, potassium chloride, monopotassium phosphate and water for injection at 30-50 DEG C to obtain a solution B; under the condition of carbon dioxide, the solution A and the solution B are filled into a first cavity and a second cavity of a peritoneal dialysis solution bag respectively, terminal sterilization is conducted, and the sterilized clean perfusate for the cerebrospinal cord operation is obtained; and performing light inspection on the sterilized clean perfusate for the cerebrospinal cord operation, putting a carbon dioxide indicator outside a peritoneal dialysis solution bag, and sleeving an outer packaging bag to obtain the clean perfusate for the cerebrospinal cord operation. According to the preparation method provided by the invention, the product quality of the washing perfusate can be remarkably improved, and the pH and osmotic pressure long-term stability of the washing perfusate can be improved.

Preparation method of insulin secreting type gene engineering cell medicine

Absstract of: CN122465963A

The invention discloses a preparation method of an insulin secreting type cell drug, and an AP2-hINS-P2A sequence designed by the invention accidentally finds that after stem cells are differentiated into fat cells, the insulin secreting function caused by sugar stimulation can be performed. The adipocytes have relatively strong insulin sensitivity and high glucose uptake rate, and potential hazards caused by high expression of insulin are in a controllable range, so that the risk that various cells express insulin indifferentially after in-vivo transfection in a gene therapy is avoided, and threats to health of patients are avoided. Meanwhile, the activation of the promoter provided by the invention fully utilizes the trans-element of the cell, so that the efficiency of the effector cell is higher, and the tissue specificity is better.

Positioning device for insulin syringe

Absstract of: CN224557839U

The utility model relates to the technical field of insulin syringes, in particular to a positioning device for an insulin syringe, which comprises a pen shell, a storage cavity is arranged at the bottom of the pen shell, the storage cavity is used for placing an insulin storage cylinder, an injection mechanism is arranged at the top of the pen shell, a positioning mechanism is arranged on the storage cavity, and the positioning mechanism is used for positioning the insulin syringe. The injection mechanism comprises a connecting ring block. According to the insulin injection device, the hollow sleeving cylinder is pressed, the needle head is driven to pierce the skin, then insulin in the cylinder body is injected into the body through the needle head till the hollow sleeving cylinder abuts against the pen shell, at the moment, injection is finished, and the output amount is adjusted by rotating the hollow sleeving cylinder to adjust the distance between the hollow sleeving cylinder and the pen shell; a patient does not need to manually observe needle penetration, discomfort caused by visual anxiety of the patient is reduced, and meanwhile, the injection comfort, safety and convenience are improved by reasonably adjusting the injection depth and the insulin dosage.

Quantitative injection pen type insulin syringe

Absstract of: CN224557842U

The utility model discloses a quantitative injection pen type insulin syringe, which comprises a syringe body, a medicament bin, an injection needle and a protective shell cap, the protective shell cap is buckled on one side of the syringe body with the injection needle and the medicament bin, the rear end of the syringe body is provided with an injection pressing part, the injection pressing part comprises a pressing rod body with an external thread groove, and the pressing rod body is provided with an external thread groove. The pressing rod body is further provided with a limiting hole groove, and the injector body is provided with a limiting sleeve with a reset spring, a limiting ball matched with the limiting hole groove and a ball hole communicating with the limiting hole groove and the inner wall of the limiting sleeve. The insulin syringe is simple in structure and convenient to use, quantitative injection can be achieved by rotating the pressing rod body until the limiting ball is clamped, then the limiting pressing tail end is removed, operation of a patient with inaccurate quantification and inconvenience during independent use is facilitated, limiting can be rapidly removed by operating the limiting sleeve, and then the insulin syringe is convenient to use. And the device can be used for injection of normal patients only by simply operating the limiting sleeve.

Diabetic foot risk grading evaluation and protection intervention implementation method

Absstract of: CN122474332A

The invention discloses a diabetic foot risk grading evaluation and protection intervention implementation method, and relates to the technical field of medical health monitoring. According to the method, foot temperature, pressure, humidity and behavior data are collected, multi-dimensional data are processed, risk characteristic parameters are extracted, a risk score value is calculated based on a preset risk assessment model, and risk grading is performed according to the score value; on the basis, a protection intervention strategy library is called to generate a control instruction, and a protection execution device is driven to implement intervention measures such as pressure reduction, temperature control and ventilation on the feet; in the intervention process, data are continuously collected, and the risk state is dynamically corrected, so that closed-loop control is formed. According to the method, the linkage of risk assessment and intervention execution is realized, the occurrence risk of the diabetic foot can be effectively reduced, and the timeliness and accuracy of protection are improved.

Large model prediction system for diabetes complicated with coronary heart disease based on multi-modal data

Absstract of: CN122474338A

The invention provides a large model prediction system for diabetes complicated with coronary heart disease based on multi-modal data, and relates to the technical field of medical information. The method comprises the following steps: acquiring medical record description information, inspection information, electrocardiogram information, coronary artery image information and carotid artery ultrasonic image information of a diabetic patient; obtaining medical record feature information; obtaining test data feature information; electrocardiogram observation feature information is obtained; obtaining medical image observation feature information; obtaining coronary heart disease risk prediction information; determining coronary heart disease condition development information; and obtaining coronary heart disease risk prompt information. According to the invention, multi-modal information can be deeply fused based on medical records, examination, electrocardiograms, coronary artery images and carotid artery ultrasonic images, the development trend of the coronary heart disease is predicted, automatic real-time prediction and identification are realized, and the diagnosis accuracy is improved; and the accuracy of diagnosis evaluation and clinical decision support providing under the condition of high diagnosis uncertainty or complexity is improved.

Integrated sharp instrument box

Absstract of: CN224557843U

The utility model relates to an integrated sharp instrument box which comprises a box body, a top cover, a main opening, a common needle cylinder imbedding opening, an insulin needle and spiral needle imbedding opening, a scissor opening and a guide wire withdrawing assembly. An upper cover is arranged on the box body, and the top cover is hinged to the upper portion of the upper cover. The main opening is a square hole area and is provided with an inclined baffle, and disposable consumables can be put in and slide in the main opening. The common needle cylinder imbedding opening is a round hole area, and the insulin needle head and the spiral needle head imbedding opening are cross-shaped hole areas. The scissors openings are V-shaped openings, cutting edges are arranged on the edges, and the needle head and the hose can be automatically separated. The guide wire withdrawing assembly comprises a withdrawing opening, a withdrawing pipe and a winding assembly, and the medical guide wire is inserted into the withdrawing pipe through the withdrawing opening and is wound by the winding assembly. Compared with the prior art, recycling of the medical guide wire is achieved, resource waste is avoided, meanwhile, the automatic separation function is achieved, operation is easy and convenient, the risk that medical staff are punctured by a needle head is reduced, and operation safety is improved.

Dynamic functional imaging OCT (optical coherence tomography) and lesion prediction method based on multi-module collaboration

Absstract of: CN122460872A

The invention discloses an OCT (optical coherence tomography) and lesion prediction method based on multi-module collaborative dynamic functional imaging. According to the method, multi-modal data are synchronously collected through an OCT system, blood vessel level identification and blood flow parameter calculation are achieved, and an abnormal area is marked in combination with eye movement tracking and motion correction technologies; analyzing dynamic blood oxygen changes of different levels of the retina by adopting a three-waveband spectrum acquisition and pigment correction algorithm; ischemic and metabolic lesions are distinguished by establishing a blood oxygen-blood flow matching model; and finally, fusing multi-parameter features to realize development risk prediction and personalized follow-up strategy generation of diseases such as diabetic retinopathy. The system has the advantages of integrating multi-modal data fusion, dynamic function imaging and disease risk prediction, realizes a whole-process closed loop from imaging to clinical decision, and remarkably improves the early diagnosis and precise management capability of ophthalmic diseases.

DEVICE FOR COLLECTION OF VOLATILE COMPOUNDS FROM SKIN FOR NON-INVASIVE MEASUREMENT OF BLOOD-GLUCOSE VALUES

Absstract of: WO2021167918A1

A volumetric sampling apparatus for volatile compounds comprises a structure, such as a channel structure that forms a continuous curve between the inlet port and the outlet port. A gas flow induced in the structure urges volatile compounds collected via transdermal diffusion toward the outlet port, where the volatile compounds may be collected and analyzed.

Lunar-phase insulin syringe

Absstract of: CN122440935A

The invention relates to the technical field of insulin injection, in particular to a lunar phase insulin syringe which comprises a syringe body, a protective clamping cover, a connecting chuck, a connecting clamping ring, a connecting ring, a connecting threaded ring, a connecting threaded groove, a connector and a needle. The connecting clamping ring is fixedly connected to the bottom end of the connecting chuck, the protective clamping cover is fixedly connected to the bottom end of the connecting chuck through the connecting clamping ring in a clamped mode, the connecting threaded ring is fixedly connected to the middle of the bottom end of the injector body, the connecting ring is fixedly connected to the bottom end of the connecting chuck, and the connecting threaded ring is located in the connecting ring. And the connecting thread groove is formed between the connecting thread ring and the connecting ring. According to the insulin injection needle, a decorative pattern can be left around an injection needle eye in the process that the needle is inserted into the skin to inject insulin through the connection adjusting part and the imprinting part, the pattern can shield the needle eye, and the position and the number of times of injection can be conveniently known by observing the pattern.

Compression event detection and prevention

Absstract of: CN122458908A

A continuous analyte monitoring system includes an analyte sensor configured to sense analytes such as lactate and glucose in tissue of a user. A controller is coupled to the analyte sensor and is configured to evaluate a first sample of an output of the first analyte sensor and a second sample of an output of the second analyte sensor to determine whether the first sample and the second sample are indicative of a compression of the tissue. The controller compensates for compression of the tissue relative to the first sample. A force sensor may be used and may be positioned between a circuit board and a housing, the circuit board being supported by a support that provides a preload for the force sensor. A force deflector may be used to direct a load away from tissue holding the analyte sensor. The housing may have a flexible lower surface to reduce tissue loading.

Insulin needle safety protection structure

Absstract of: CN122440942A

The invention provides an insulin needle head safety protection structure which comprises a needle seat and a protection cover, the hollow inner edge of the needle seat can be used for arranging a needle head, and a first pivoting part and a positioning part positioned at the opposite end of the first pivoting part are arranged at the proper position of the outer edge surface of the needle seat; the outer end, corresponding to the first pivoting part, of the protecting cover is provided with a second pivoting part capable of being combined in a pivoting mode, a transparent part is formed at the position adjacent to the second pivoting part, the other end of the protecting cover is provided with an embedding part, and the embedding part is fixed after being embedded into the positioning part. A first notch portion and a second notch portion are arranged at proper positions of the outer end face and the inner wall face, adjacent to the embedding portion, of the protective cover, coamings are arranged on two sides between the second pivot portion and the embedding portion, a hollow portion is formed on the inner edge of the protective cover, the protective cover can cover the needle seat after the insulin needle is used, a needle body can be covered, and the insulin needle can be prevented from being damaged. And the needle body can be bent and damaged, so that the protection effect is improved.

Entity boundary perception and double-layer selective coupling liver, gall and pancreas text classification method

Absstract of: CN122451150A

The invention relates to the technical field of natural language processing, artificial intelligence and digital economy, in particular to an entity boundary perception and double-layer selective coupling liver, gall and pancreas text classification method, which comprises the following steps: acquiring and coding a liver, gall and pancreas text to obtain text feature representation; carrying out entity boundary perception continuous candidate evidence generation, and constructing entity-level and context-level dual-granularity discrete measure and an entity fragment membership matrix; adopting a type consistency hard anchoring strategy to construct double-layer prototype distribution; a double-layer transmission plan is obtained by adopting a semi-constrained optimal transmission target of Tsallis-2 regularization in cooperation with weighted L2 relative quality relaxation; performing prototype voting type aggregation based on the double-layer transmission plan, and outputting a category decision; and projecting the double-layer transmission quality to word-level saliency through a projection matrix to form quadruple verifiable interpretation. According to the method, high-precision and interpretable classification of liver, gall and pancreas texts is realized, and the accuracy, the loyalty and the stability of classification are improved.

Blood glucose physiological parameter nonlinear time series data prediction and self-adaptive feedback method

Absstract of: CN122455383A

The invention provides a blood glucose physiological parameter nonlinear time series data prediction and self-adaptive feedback method, relates to the technical field of medical monitoring, and realizes leap of blood glucose prediction from pure trend tracking to dynamic mechanism reconstruction by constructing feedback control of momentum load space-time coupling; the phase matching degree of blood glucose prediction under a sudden change working condition is improved, and the consistency of a prediction signal and a real physiological evolution trajectory in a time domain is improved; the volatility characteristic is used as a global safety threshold value, step type degradation protection logic based on a coupling vector is triggered when a chaos instability state is detected, and the common feedback overshoot and oscillation risks in the automatic drug delivery process are restrained; according to the invention, on the premise of ensuring high prediction sensitivity, the robustness and individual suitability of the medical monitoring system are enhanced.

Insulin pen refrigeration cup

Absstract of: CN224540691U

The utility model provides an insulin pen refrigeration cup, an insulin pen refill is arranged in an insulin pen, the insulin pen refrigeration cup comprises a refrigeration assembly, a cold guide cylinder, a cup cover and a cup body, the cold guide cylinder defines a containing space capable of containing at most one or two insulin pens, the containing space is also suitable for containing the insulin pen refill, and/or the cup cover is suitable for containing the insulin pen refill. The diameter range of the cold guide cylinder is 20-50 mm, the cold guide cylinder comprises an avoiding groove, the avoiding groove is formed by extending from the open end to the sealed end, the cup cover is suitable for containing the refrigeration assembly, the cup body comprises a cup wall and a heat preservation cavity defined by the cup wall, the open end extends into the heat preservation cavity, and the cup cover detachably seals the heat preservation cavity. Part of the insulin pen or part of the insulin refill can extend into the avoiding groove or enter the heat preservation cavity through the avoiding groove, and the refrigeration assembly enables the interior of the heat preservation cavity to be kept in a low-temperature state. The size of the cold guide cylinder is limited, and the receding groove is formed, so that the size is obviously reduced.

Auxiliary detection device for treating diabetic patient

Nº publicación: CN122440187A 24/07/2026

Applicant:

XIAMEN OPHTHALMOLOGY CENTER CO LTD
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Absstract of: CN122440187A

The invention discloses an auxiliary detection device for treating diabetic patients, and relates to the technical field of diabetes mellitus detection.The auxiliary detection device comprises a blood sampling pen and a glucometer and further comprises a fixing block, the fixing block is fixed between the blood sampling pen and the glucometer and used for connecting the blood sampling pen and the glucometer, and the blood sampling pen and the glucometer are sleeved with a housing; one side of the housing is open, and the other side of the housing is provided with a through hole. The blood sampling pen has the beneficial effects that the blood sampling pen and the blood glucose meter are combined together through the arrangement of the auxiliary assembly, in the detection process, the steps of puncturing and blood sampling can be completed without intervals, multi-step hand changing operation is omitted, the exposure time of a blood sample is shortened, blood coagulation, oxidation, dripping or pollution are avoided, the purity of the blood sample is guaranteed, the detection accuracy is improved, and the detection efficiency is improved. And the operation process is greatly simplified and can be completed by a single hand, so that the use difficulty of old people and patients with poor eyesight and mobility inconvenience is reduced, and the monitoring compliance and safety are improved.