Alerta

NOVEL IONIZABLE LIPIDS

Absstract of: MX2025004314A

The present invention relates to compounds of formula (I). The invention also extends to micro- or nanoparticles comprising a compound of formula (I). For instance, compounds of formula (I) can be used to produce stable lipid nanoparticles (LNPs). The LNPs have high encapsulation efficiency and can be used to deliver a therapeuticor prophylactic agent to a patient.

脂質封入ＲＮＡナノ粒子の製造方法

Absstract of: US2025177305A1

A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1″ and 0.132″; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005″ and 0.02″ at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.

一种基于CMCS封装性多孔金纳米壳对紫杉醇的增溶方法

Absstract of: CN120501719A

本发明涉及药物制剂技术领域，尤其涉及基于CMCS封装的多孔金纳米壳在紫杉醇药物输送上的应用。本技术方法为将通过CMCS封装的多孔金纳米壳作为紫杉醇药物的载体，从而能够在使用时实现对PTX的pH响应性释放。本发明提供的基于CMCS封装性多孔金纳米壳在紫杉醇药物输送上的应用，将多孔金纳米壳与紫杉醇药物混合，并通过CMCS进行封装形成的CMCS/PTX/EHGNs，能够在癌症治疗时提升其水溶性和生物利用度。

一种载有酚醛网络的白蛋白纳米粒子的制备方法及应用

Absstract of: CN120501722A

本发明适用于生物医药技术领域，提供了一种载有酚醛网络的白蛋白纳米粒子的制备方法及应用。本发明通过将表没食子儿茶素没食子酸酯‑铜(EGCG‑Cu)金属酚醛网络(EC NPs)负载于牛血清白蛋白纳米粒子(BSANPs)内，构建了一种智能纳米输送体系(BEC NPs)。该体系可特异性靶向炎症部位中性粒细胞，响应炎症微环境释放EC NPs，通过清除活性氧、抑制中性粒细胞外陷阱形成、促进巨噬细胞向M2型极化、抑制细胞焦亡等机制改善炎症微环境，缓解炎症损伤。体内实验显示BEC NPs能促进牙槽骨再生和牙周组织修复，生物相容性良好，为慢性牙周炎提供了兼具抗炎、免疫调控和组织修复功能的纳米治疗策略。

一种环状多倍串联RNA正义链

Absstract of: CN120505342A

本发明提供了一种环状多倍串联RNA正义链，其包括至少一个正义链序列和至少一个间隔序列。该环状RNA衍生自含有所有必需序列的工程化亲本DNA模板，其按以下顺序包括第一环化元件、任选地至少一个第一限制性酶识别序列、至少一个靶序列、任选地至少一个第二限制性酶识别序列和第二环化元件。该环状多倍串联RNA正义链可以结合并递送多个反义链RNA，在利用环状RNA稳定性优势的同时增加正义链和反义链的结合。

Composiciones de nanopartículas lipídicas

Absstract of: US2025090471A1

The disclosure provides lipid nanoparticle (LNP) compositions of ionizable lipids, helper lipids, neutral lipids, and PEG lipids useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The LNP compositions disclosed herein are useful in methods of gene editing and methods of delivering a biologically active agent and methods of modifying or cleaving DNA.

一种药物组合物及其应用

Absstract of: CN120501756A

本发明公开了一种药物组合物，其包含环状RNA以及药物递送载体。与传统线性1×siRNA和环状1×siRNA相比，本公开将正义链重复串联数量增加到包括但不限于2个以上，意外地发现显著增强了沉默效果，能够显著降低PCSK9基因的表达水平，介导PCSK9蛋白的mRNA的降解。使用纳米颗粒递送寡核苷酸，增加了稳定性，降低了免疫原性，提高了降胆固醇、减少主动脉斑块负荷、抗动脉粥样硬化的作用，且安全无明显肝肾毒性，在制备高胆固醇血症、冠心病的治疗药物方面具有广阔的应用前景。

食品级乳液纳米颗粒联合自噬抑制剂在制备抗肿瘤药物中的应用

Absstract of: CN120501721A

本发明属于生物医药及纳米技术领域，具体公开了食品级乳液纳米颗粒联合自噬抑制剂在制备抗肿瘤药物中的应用，所述食品级乳液纳米颗粒是以大豆油为基础油相，单甘油脂为乳化剂，PBS为水相混合制成的乳液纳米颗粒FLNs；所述自噬抑制剂为3‑MA。本发明利用“撑死”肿瘤细胞的策略，采用食品级乳液纳米颗粒FLNs联合自噬抑制剂3‑MA瘤内注射，实现皮下异质瘤生长及转移的有效抑制，且未发现任何明显的毒副作用，有望开发为一种基于瘤内注射的安全高效抗肿瘤策略。

一种靶向型白蛋白球形核酸药物及其制备方法和使用方法

Absstract of: CN118986929A

The invention belongs to the field of research and development of tumor drugs, and provides a targeted albumin spherical nucleic acid drug for delivering a hydrophobic drug, aiming at solving the problems that the existing traditional albumin drug is poor in targeted enrichment, strong in systemic side effect and the like, and the targeted albumin spherical nucleic acid drug is characterized in that a hydrophobic molecule is wrapped in albumin (HSA), and meanwhile, the hydrophobic molecule is used as a spherical nucleic acid drug for delivering the hydrophobic drug. Albumin with a plurality of hydrophobic structural domains on the surface and a plurality of aptamer sequences (Apt) with hydrophobic groups at the 5'end are mutually non-covalently modified and combined through hydrophobic interaction to form a spherical nucleic acid structure, and the aptamer has specific targeting property. The invention also provides a preparation method and a use method of the spherical nucleic acid medicine. The drug provided by the invention has excellent targeting property and stability, can realize specific targeting delivery of different types of tumors, improves the treatment effect of the drug, reduces toxic and side effects, and is suitable for large-scale industrial application.

一种环状RNA的制备方法

Absstract of: CN120505341A

本发明提供了一种环状RNA的制备方法，包括：使用包含至少一种RNA聚合酶启动子和核酸构建体的表达载体转化宿主细胞，其中所述核酸构建体按以下顺序从5’到3’的方向包括第一环化元件、任选地至少一个第一限制性酶识别序列、至少一个靶序列、任选地至少一个第二限制性酶识别序列和第二环化元件。该方法得到的环状RNA产量高，免疫原性低，可以结合并递送多个反义链RNA。

一种乌力地格抑菌凝胶及其制备方法

Absstract of: CN120501702A

本发明涉及妇科抑菌凝胶技术领域，具体涉及一种乌力地格抑菌凝胶及其制备方法；按重量份计包括以下组分：醋酸氯己定1‑3份、梅花草提取物4‑8份、卡波姆0.8‑1.2份、三乙醇胺0.4‑0.6份、促渗剂0.5‑1.5份、改性纳米银0.04‑0.07份、甘油5‑8份、氢化聚异丁烯0.03‑0.07份、依地酸二钠0.1‑0.3份和纯化水余量，本发明采用醋酸氯己定与梅花草乙醇提取物以1：(2.5‑4)的比例复配，梅花草中的黄酮和多酚类物质可破坏微生物细胞膜通透性，促进醋酸氯己定进入菌体内部，显著降低最小抑菌浓度。

がんにおけるフェロトーシス誘導剤としての高密度リポタンパク質様ナノ粒子

Absstract of: MX2022003239A

Disclosed herein are compositions and methods for treating a subject having cancer and other ferroptosis disorders with high density lipoprotein-like nanoparticles that induce ferroptosis.

多叔胺多尾链可电离阳离子脂质、包含其的组合物及用途

Absstract of: CN120483890A

本公开属于医药领域，更具体地，涉及递送脂质技术领域，公开了多叔胺多尾链可电离阳离子脂质、包含其的组合物及用途。本公开提供的多叔胺多尾链可电离阳离子脂，其包括如式(I)所示的结构，可用于核酸靶向递送，能够显著增强mRNA疫苗或药物的防脱靶效应。#imgabs0#

ＤＮＡ結合タンパク質を含む脂質ナノ粒子

Absstract of: AU2023326249A1

The present disclosure relates to lipid nanoparticles for delivery of DNA, the lipid nanoparticle comprising therein a DNA-binding protein or peptide bound to the DNA, and uses thereof.

核酸の送達のための硫黄含有化合物及びその組成物

Absstract of: WO2024035783A2

Lipid nanoparticle compositions (LNPs), methods for preparing the LNPs, methods of using the same, including, but not limited to, for treatment of certain diseases and disorders, including, but not limited to liver disorders, kits for the delivery of nucleic acids to various types of cells, including T-cells and hepatocytes, in vivo, ex vivo and in vitro.

ステロール系イオン化脂質及びそれを含む脂質ナノ粒子

Absstract of: CN119816292A

Compounds, compositions, and methods for delivering therapeutic, diagnostic, or prophylactic agents (e.g., nucleic acids) are described.

免疫グロブリンプロテアーゼおよびその融合体に関する組成物および方法

Absstract of: AU2023321906A1

Provided herein are compositions and methods related to compositions comprising an Ig protease fusion protein. Also provided herein are compositions and methods for therapeutic treatment, such as of autoimmune diseases, allergies, or other immunological disorders, or in combination with the administration of another therapeutic, with such Ig protease fusion protein.

一种三重协同调控的多功能复合纳米酶的制备方法

Absstract of: CN120478633A

本发明适用于生物医学技术领域，提供了一种三重协同调控的多功能复合纳米酶的制备方法，该方法构建了一种基于三重环境自适应调控机制的智能纳米酶体系AgAu C‑L。该体系通过AgAu纳米笼的光热效应精准优化催化反应温度，同时结合罗伊氏乳杆菌的益生菌代谢特性主动降低局部pH至CeO2最佳活性范围，并协同AgAu@CeO2异质结界面电子转移优化策略增强电荷传递效率，三者共同作用显著提升CeO2纳米酶在生理中性/弱碱性环境下的催化效能，特别是其过氧化物酶样活性。该智能体系不仅能高效物理清除牙周致病菌生物膜，更能通过精准干扰病原菌核苷酸合成与精氨酸代谢等关键通路瓦解微生物协同网络，最终实现口腔微生态平衡的重塑。

一种双靶向仿生水滑石无机纳米颗粒及其制备方法和应用

Absstract of: CN120478303A

本发明涉及一种双靶向仿生水滑石无机纳米颗粒及其制备方法和应用，包括：获取新鲜红细胞膜；获取衰老红细胞膜；将新鲜红细胞膜和衰老红细胞膜以一定的比例加入水滑石无机纳米颗粒中进行混合搅拌，离心得到仿生水滑石无机纳米颗粒。本发明的有益效果是：本发明双靶向仿生水滑石无机纳米颗粒具有平衡递送至肝实质细胞和肝巨噬细胞的双靶向能力，可同时缓解氧化应激和炎症反应。

一种多功能纳米复合材料的制备方法及其应用

Absstract of: CN120478306A

本发明适用于生物医学技术领域，提供了一种多功能纳米复合材料的制备方法及其应用。该材料生物相容性良好，可作为安全制剂用于肿瘤治疗；制备简便且绿色无污染；扩展了槲皮素在抗肿瘤免疫治疗中的应用；具有优异的荧光/计算机断层扫描双模式成像性能，可用于确定肿瘤边界，实现精准治疗引导；具有优良的光热及光热增强的催化性能，具备微创高效、毒副作用小且可控等优势，能通过激活免疫有效治疗原发、转移或复发性头颈部鳞状细胞癌；通过诱导肿瘤细胞释放2’3’‑cGAMP并防止其降解，高效激活cGAS‑STING信号通路，最终增强抗肿瘤免疫效果。

呕吐毒素致断奶仔猪肠道铁死亡的抑制剂及制备方法

Absstract of: CN120478304A

本发明涉及畜牧技术领域，尤其涉及一种呕吐毒素致断奶仔猪肠道铁死亡的抑制剂及制备方法，本发明整合铁螯合剂(去铁胺，DFO)、GPX4激活剂(硒甲硫氨酸，SeMet)及抗炎成分(姜黄素、黄芪多糖、双氢青蒿素)，覆盖铁蓄积、GPX4失活、脂质过氧化等铁死亡三大核心通路；同时，采用pH敏感型壳聚糖‑海藻酸钠纳米颗粒对以上成分进行包被，使其能够过胃，避免受到胃酸的破坏，确保药物在肠道的碱性环境中精准释放，从而提高药物的利用率；并且，硒甲硫氨酸、姜黄素、黄芪多糖、双氢青蒿素均为天然来源，可以避免化学药物残留风险，可作为饲料添加剂应用于断奶仔猪当中。

具格兰氏阴性菌抗菌活性的螯合型复合胶束及其应用

Absstract of: WO2024153108A1

The present invention discloses a chelating complex micelle presenting antimicrobial activity against gram-negative bacteria. The chelating complex micelle comprises metal ions, polymers having a chelating segment, and an antimicrobial agent having at least one Lewis base functional group, wherein the antimicrobial agent presenting antimicrobial activity against multi-drug-resistant gram-negative bacteria (MDR-GNB), such as carbapenem-resistant A. baumannii, P.aeruginosa, or Enterobacteriaceae.

一种含氟修饰的聚肌氨酸化脂质及其制备方法和应用

Absstract of: CN120484249A

本发明属于生物医药技术领域，公开了一种含氟修饰的聚肌氨酸化脂质及其制备方法和应用。本发明的所述含氟修饰聚肌氨酸化脂质具有如式(I)或式(II)所示结构通式。通过不同含氟基团化学改性聚肌氨酸化脂质得到的含氟修饰聚肌氨酸化脂质可以替代PEG化脂质制备脂质纳米颗粒(LNP)，用于负载核酸等药物，达到提升药物递送性能的目的。

一种mRNA脂质纳米粒及其制备方法和应用

Absstract of: CN120478287A

本发明涉及纳米生物技术领域，提出了一种mRNA脂质纳米粒及其制备方法和应用。该mRNA脂质纳米粒，通过透明质酸酶（HAase）修饰以降解肿瘤细胞外基质中的透明质酸，改善肿瘤微环境，降低肿瘤组织的屏障作用，从而增强mRNA‑LNP的渗透性。此外，该体系在肿瘤微酸环境下可发生粒径翻转，提高肿瘤深层细胞的递送效率。实验结果表明，该递送体系可有效提高mRNA在肿瘤组织中的渗透能力和抗肿瘤疗效，为肿瘤基因治疗提供了一种新的策略。

用于成纤维细胞生长因子受体3介导的至星形胶质细胞的递送的组合物及方法

Nº publicación: CN120500498A 15/08/2025

Applicant:

瑞泽恩制药公司

Absstract of: AU2023379457A1

The present invention provides, in part, protein-drug conjugates comprising an anti-fibroblast growth factor receptor 3 (FGFR3) (e.g., human FGFR3) antigen-binding protein (e.g., scFv, Fab) conjugated to a molecular cargo (e.g., polynucleotides, polypeptides, liposomes or lipid nanoparticles) for delivery of the molecular cargo to a targeted tissue (e.g., brain). Methods for treating various diseases or disorders, such as neurological diseases, with the conjugates are provided.