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210
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Updated on
21/02/2026 [06:51:00]
Results 200 to 210 of 210
Absstract of: CN121466030A
本发明公开了一种工程化免疫细胞及其制备方法和应用，工程化免疫细胞通过基因工程改造，基因组中稳定整合有(1)由热休克蛋白HSP70启动子控制的Gasdermin D N‑端片段(GSDMD‑N)表达框；且细胞内负载有(2)用于外源刺激升温的光热转换材料和/或磁性纳米颗粒；以及(3)用于治疗性装载的减毒细菌和/或抗肿瘤药物；其中，HSP70启动子的核苷酸序列如SEQ ID NO:1所示，所述GSDMD‑N的核苷酸序列如SEQ ID NO:2所示。该发明实现了装载在免疫细胞内的细菌等抗癌药物在肿瘤部位的精准、可控部署，兼具良好的抗肿瘤效果和较高的安全性，为细胞疗法以及活体微生物抗肿瘤疗法提供了新的技术平台。
Absstract of: CN121465986A
本发明公开了一种载药微凝胶‑凝胶缓释敷料及其制备方法和应用。该敷料包括由GelMA微球负载的药物微凝胶相和由CSMA与含双键小分子交联剂共聚形成的水凝胶外壳相，可通过紫外光原位聚合固化。所载药物包括贝伐珠单抗、曲安奈德和氟尿嘧啶中的一种，实现多药协同缓释。本发明敷料具有良好的生物相容性、可降解性、形状适应性和缓释性能，可显著提高局部药物浓度、减少给药频次、提升患者依从性，适用于瘢痕疙瘩的治疗与修复。
Absstract of: CN121466311A
本发明公开了一种脂质组合物及其在核酸递送中的应用。通过皮下给药，所述脂质组合物可用于递送siRNA，旨在实现优于现有商业化配比的脂质组合物的关节炎治疗效果。本发明提供的脂质组合物可用于递送核酸类药物，与已上市的LNP配方相比，降低了可电离阳离子脂质的占比，增加了PEG脂质的占比。所述脂质组合物在递送用于治疗自免类疾病的siRNA时，通过关节腔附近皮下注射给药，尤其是在胶原蛋白诱导的大鼠关节炎（CIA）的治疗中表现出较好的效果，显著降低关节炎评分和足体积。
Absstract of: WO2024228632A1
The description of the invention discloses a stable polymer-lipid nanoparticle for drug binding and delivery comprising a core containing polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA) and a core envelope containing a mixture of lipids: 1,2-dipalmitoyl-sn-glycero-3- phosphocholine (DDPC), cholesterol and the ammonium salt of 1,2- distearoyl-sn-glycero-3-phosphoethanolamine-N -amino(polyethylene glycol)-2000 (DSPE-PEG(2000)NH2 and a method for producing such particles.
Absstract of: CN121466007A
本发明提出了一种预防缺血性脑卒中的药物及其制备方法和应用，属于医药技术领域。将β‑细辛醚与半胱氨酸反应制得β‑细辛醚/半胱氨酸偶联物；将中性粒细胞膜蛋白与纳米二氧化铈混合制备仿生纳米脂质体；将老鹳草素和牛奶外泌体共孵育制备载药外泌体，与仿生纳米脂质体超声孵育制得仿生融合体，与β‑细辛醚/半胱氨酸偶联物混合均匀，冷冻干燥，制得预防缺血性脑卒中的药物。本发明预防缺血性脑卒中的药物具有低免疫原性、较好的血脑屏障穿透率，稳定性佳，口服利用率高，提高了患者依从性，降低了成本，具有较好的预防及治疗缺血性脑卒的效果，具有广阔的应用前景。
Absstract of: US2025032620A1
Formulated and/or co-formulated liposomes, lipid nanoparticle (LNP) and solid-lipid nanoparticles (SLNP) comprising TB Prodrugs and methods of making the LNPs and SLNPs are disclosed herein. The TB prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit ALK5. The TB Prodrugs can be formulated and/or co-formulated into a nanocarrier to provide a method of treating cancer, immunological disorders, and other diseases by utilizing a targeted drug delivery vehicle.
Absstract of: CN120676962A
Disclosed herein are RSV F glycoproteins and nanoparticles comprising the glycoproteins suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounding and associated with the detergent core, resulting in enhanced stability and good immunogenicity. Doses, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
Absstract of: CN120475990A
The present disclosure relates to a fusion protein comprising an extracellular domain of a viral fusion protein linked to one or more heptapeptide repeats (HR) from the SARS-COV-2 spike (S) protein or the respiratory syncytial virus (RSV) F protein, and uses thereof. The viral fusion proteins are suitable for use as vaccines.
Absstract of: CN121466034A
本发明属于微型机器人技术领域，具体为一种脉冲激光响应性胶体体微纳米机器人及其制备方法与应用，该微纳米机器人为球形结构，由内至外包括核心层和功能层，功能层包覆核心层；核心层为热响应性相变材料，功能层为贵金属纳米材料，功能层的贵金属纳米材料能够吸收并转化近红外脉冲激光为热，使得核心层发生相变，驱动该微纳米机器人实现步进运动并穿透物理屏障。通过高能超声机械乳化、化学还原等步骤制备得到微纳米机器人。该微纳米机器人可作为通用载体，用于化疗药物、基因药物或光热治疗剂的负载，为肿瘤深部递送、血脑屏障穿透等实现“屏障穿透‑靶向给药‑协同治疗”一体化功能，为脑胶质瘤等疾病的诊疗等提供全新技术路径。
Nº publicación: CN121487722A 06/02/2026
Applicant:
北京剂泰生命科技有限公司剂泰科技（北京）股份有限公司
Absstract of: AU2024251515A1
The present application relates to lipid nanoparticles containing a steroid compound, and the preparation and a use of the lipid nanoparticles. The lipid nanoparticles can be used to deliver effective loads (such as a nucleic acid) into non-liver organs such as the spleen for the treatment or prevention of certain diseases or conditions, particularly spleen-associated diseases.
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