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LastUpdate Updated on 20/08/2026 [06:45:00]
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Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days
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METHODS FOR PREDICTING RESPONSIVENESS OF LYMPHOMA TO DRUG AND METHODS FOR TREATING LYMPHOMA

Publication No.:  EP4791907A1 19/08/2026
Applicant: 
BRISTOL MYERS SQUIBB CO [US]
Bristol-Myers Squibb Company
WO_2025080543_PA

Absstract of: WO2025080543A1

Provided herein are methods of predicting the responsiveness of a lymphoma patient to a cancer treatment. Also provided herein are methods of treating a lymphoma patient based on predicting the responsiveness of the lymphoma patient to a cancer treatment.

METHODS FOR TREATING MULTIPLE MYELOMA COMPRISING AN ANTI-CD38 ANTIBODY COMBINED WITH BORTEZOMIB, LENALIDOMIDE AND DEXAMETHASONE

Publication No.:  EP4791505A1 19/08/2026
Applicant: 
JANSSEN BIOTECH INC [US]
Janssen Biotech, Inc.
WO_2025080911_PA

Absstract of: WO2025080911A1

The present disclosure is directed to methods of treating multiple myeloma. The present disclosure is directed to methods of treating newly diagnosed multiple myeloma in a subject in need thereof, for example, by subcutaneously administering to the subject a pharmaceutical composition comprising an anti-CD38 antibody in combination with bortezomib, lenalidomide, and dexamethasone.

COMPOUNDS FOR TREATING BRAIN CANCER

Publication No.:  US20260232638A1 13/08/2026
Applicant: 
PURDUE PHARMACEUTICAL PRODUCTS L P [US]
Purdue Pharmaceutical Products L.P.
US_20260232638_A1

Absstract of: US20260232638A1

0000 There is provided a compound of formula I or a pharmacologically acceptable salt thereof: 0000 for use in the treatment of a brain cancer selected from a MGMT positive astrocytic brain tumor, a metastatic brain cancer and primary CNS lymphoma and a method of treating said brain cancers in a patient in need thereof comprising administering to the patient said compound of formula I or a pharmacologically acceptable salt thereof.

ANTI-VISTA ANTIBODIES AND FRAGMENTS

Publication No.:  US20260234264A1 13/08/2026
Applicant: 
JANSSEN PHARMACEUTICA NV [BE]
JANSSEN PHARMACEUTICA NV
US_20260234264_A1

Absstract of: US20260234264A1

The present invention relates to novel antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of making and using same. Methods of use include methods of treatment of cancer, including leukemias, lymphomas, solid tumors and melanomas.

Use of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (HIF-PHI) in Rare Anemia

Publication No.:  US20260234146A1 13/08/2026
Applicant: 
KIND PHARMACEUTICAL [CN]
Kind Pharmaceutical
US_20260234146_A1

Absstract of: US20260234146A1

The present application relates to use of a hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHI) in rare anemia. Specifically disclosed in the present application is use of certain hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) in the treatment of anemia of myelodysplastic syndromes (MDS anemia), beta-thalassemia (β-thalassemia), and/or sickle cell disease (sickle cell anemia, SCD anemia).

CRYSTALLINE FORMS OF N-4-4-(4-MORPHOLINYL)-7H-PYRROLO2,3-DPYRIMIDIN-6- YLPHENYL-4-3(R)-(L-OXO-2-PROPEN-L-YL)AMINO-L-PIPERIDINYLMETHYL-2-PYRIDINECARBOXAMIDE AS A COVALENT INHIBITOR OF MENIN-MLL INTERACTION

Publication No.:  US20260232681A1 13/08/2026
Applicant: 
BIOMEA FUSION INC [US]
BIOMEA FUSION, INC.
US_20260232681_A1

Absstract of: US20260232681A1

0000 Described herein is N-4-4-(4-morpholinyl)-7H-pyrrolo2,3-dpyrimidin-6-ylphenyl-4-3(R)-(1-oxo-2-propen-1-yl)amino-1-piperidinylmethyl-2-pyridinecarboxamide (Compound A) (Formula I), including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions or pharmaceutical formulations that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, diabetes, and inflammatory diseases or conditions. 0000

ANTI-CD180 BINDING MOLECULES AND USES THEREOF

Publication No.:  US20260232824A1 13/08/2026
Applicant: 
CHAMPIONS ONCOLOGY INC [US]
Champions Oncology, Inc.
US_20260232824_A1

Absstract of: US20260232824A1

0000 The present disclosure provides anti-CD180 binding molecules and uses thereof. In one embodiment, the anti-CD180 binding molecules are anti-CD180 antibodies. Also provided are anti-CD180 antibody-drug conjugates (ADCs) comprising a CD180-high expressing tumor-targeting monoclonal antibody or antigen-binding fragment thereof, a cytotoxic drug payload and a linker moiety conjugating the CD180-high expressing tumor-targeting antibody or the antigen-binding fragment thereof to the cytotoxic drug payload. The anti-CD180 antibodies or the antigen binding fragments thereof, and the ADCs comprising the anti-CD180 antibodies, or the antigen binding fragments thereof are useful in treating diseases, such as acute myeloid leukemia, mantle cell lymphoma, multiple myeloma. follicular lymphoma, B-acute lymphoblastic leukemia, or diffuse large B-cell lymphoma.

Low dose antibody-based methods for treating hematologic malignancies

Publication No.:  US20260234248A1 13/08/2026
Applicant: 
ACTINIUM PHARMACEUTICALS INC [US]
Actinium Pharmaceuticals, Inc.
US_20260234248_A1

Absstract of: US20260234248A1

0000 This invention provides a method for treating a subject afflicted with a hematologic malignancy comprising administering to the subject an agent targeting a hematologic malignancy-associated antigen, wherein the subject has a low peripheral cancerous cell burden. This invention also provides a method for treating a subject afflicted with a hematologic malignancy and having a high peripheral cancerous cell burden, comprising (i) medically lowering the subject's peripheral cancerous cell burden, and (ii) while the subject's peripheral cancerous cell burden is still low, administering to the subject an agent targeting a hematologic malignancy-associated antigen. Particularly envisioned are the subject methods for treating acute myeloid leukemia using an anti-CD33 antibody labeled with an alpha-emitting isotope, such as <225>Ac-HuM195.

NOVEL IMIDAZOLE DERIVATIVE AND USE THEREOF

Publication No.:  US20260234129A1 13/08/2026
Applicant: 
PELEMED CO LTD [KR]
GWANGJU INST OF SCIENCE AND TECHNOLOGY [KR]
PELEMED CO., LTD.
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
US_20260234129_A1

Absstract of: US20260234129A1

The present invention relates to a novel imidazole derivative and a pharmaceutical composition for treating protein kinase-associated diseases, comprising same as an active ingredient. More specifically, the present invention relates to a novel imidazole derivative and a pharmaceutical composition comprising same as an active ingredient, the derivative inhibiting protein kinase activity so as to prevent or treat cancer diseases. In addition, the compound and the pharmaceutical composition, comprising same as an active ingredient, of the present invention, effectively inhibit FLT3 kinase activity, and thus can be effectively used for preventing or treating mutant FLT3-associated diseases, particularly acute myeloid leukemia.

CIRCULAR RNA ENCODING CARS AND THE USE THEREOF

Publication No.:  AU2024415673A1 13/08/2026
Applicant: 
THERORNA SHANGHAI CO LTD
THERORNA SHANGHAI CO., LTD.
AU_2024415673_A1

Absstract of: AU2024415673A1

Provided is a circular RNA encoding CARs and the use thereof to create immune cells that target specific diseases, e. g., lymphoma, multiple myeloma and leukemia and auntoimmune diseases, such as systemic lupus erythematousus, lupus nephritis and myasthenia gravis.

THERAPY FOR THE TREATMENT OF NON-HODGKIN LYMPHOMA

Publication No.:  US20260232683A1 13/08/2026
Applicant: 
CELGENE CORP [US]
HOFFMANN LA ROCHE INC [US]
GENENTECH INC [US]
Celgene Corporation
Hoffmann-La Roche Inc.
Genentech Inc.
US_20260232683_A1

Absstract of: US20260232683A1

0000 Provided herein are methods of treating and/or managing non-Hodgkin lymphoma, which comprise administering to a patient 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione (“Compound A, A-S, or A-R”), or an enantiomer or mixture of enantiomers, a tautomer, an isotopolog, a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, in combination with glofitamab or mosunetuzumab.

METHODS OF TREATING LEUKEMIA OR LYMPHOMA

Publication No.:  US20260232807A1 13/08/2026
Applicant: 
INST PASTEUR DE MONTEVIDEO [UY]
UNIV DE LA REPUBLICA [UY]
ARDAN PHARMA S A S [AR]
INSTITUT PASTEUR DE MONTEVIDEO
UNIVERSIDAD DE LA REP\u00DABLICA
ARDAN PHARMA S.A.S.
US_20260232807_A1

Absstract of: US20260232807A1

A method of impairing cancer cell growth in a mammal having leukemia or lymphoma is disclosed, the method including administering to the mammal a pharmaceutical composition comprising a pharmacologically active amount of (+)-BAY K8644 as a monotherapy or in combination with the tyrosine kinase inhibitor, Ibrutinib.

Keratin YK93-8, and Preparation Method Therefor, Pharmaceutical Composition Thereof and Use Thereof

Publication No.:  US20260234207A1 13/08/2026
Applicant: 
INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES [CN]
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
US_20260234207_A1

Absstract of: US20260234207A1

0000 The present invention belongs to the field of biopharmaceuticals. Provided in the present invention are keratin YK93-8, a nucleic acid molecule encoding same, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a host cell having the nucleic acid molecule integrated into the genome, as well as a method for preparing keratin YK93-8 and a pharmaceutical composition of keratin YK93-8. Further provided is the use of the above-mentioned keratin YK93-8 and other products in the preparation of drugs, such as a drug for treating hyperplasia of prostate, lymphoma, melanoma, breast cancer, lung cancer and uterine myoma, an analgesic, a lactation drug and a coagulant.

Methods for Treating Multiple Myeloma

Publication No.:  US20260234630A1 13/08/2026
Applicant: 
CELGENE CORP [US]
Celgene Corporation
US_20260234630_A1

Absstract of: US20260234630A1

0000 Provided herein are methods of treating multiple myeloma, including multiple myeloma that is resistant to at least one therapeutic agent, comprising administering to a subject with multiple myeloma an inhibitor of Ubiquitin-Like with PHD and Ring Finger Domains 1 (UHRF1).

SUPER RESOLUTION MICROSCOPIC IMAGING OF T LYMPHOCYTE CLONALITY COMBINING MULTIPLEXED SEQUENTIAL FLUORESCENCE IN SITU HYBRIDIZATION WITH BULK GENOMIC DNA SEQUENCING

Publication No.:  WO2026170226A1 13/08/2026
Applicant: 
CALIFORNIA INST OF TECHNOLOGY [US]
CALIFORNIA INSTITUTE OF TECHNOLOGY

Absstract of: WO2026170226A1

This disclosure provides methods for imaging of samples for diagnosis of lymphoid neoplasms, lymphocytic autoimmune disease, and other conditions related to clonal expansion of lymphocytes. Using these methods, individual lymphocytes can be imaged in situ to determine tissue-wide clonality based on rearrangement of T cell receptor gene segments. Post hoc bulk sequencing allows for complementarity determining sequences to be mapped back to individual lymphocyte clones in super resolution images. In additional to its clinical applications in histopathology, these methods are also useful for the study of cellular and immunologic processes related to lymphoproliferative and autoimmune disorders.

CCR9 TARGETING MOIETY FOR THE TREATMENT OF CCR9-POSITIVE CANCER

Publication No.:  US20260232732A1 13/08/2026
Applicant: 
FUNDACIO INST DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS [ES]
INST CATALANA DE RECERCA | ESTUDIS AVANCATS [ES]
ONECHAIN IMMUNOTHERAPEUTICS SL [ES]
FUNDACIO INST DINVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS | PUJOL [ES]
FUNDACI\u00D3 INSTITUT DE RECERCA CONTRA LA LEUC\u00C8MIA JOSEP CARRERAS
INSTITUCI\u00D3 CATALANA DE RECERCA | ESTUDIS AVAN\u00C7ATS
ONECHAIN IMMUNOTHERAPEUTICS SL
FUNDACI\u00D3 INSTITUT D'INVESTIGACI\u00D3 EN CI\u00C8NCIES DE LA SALUT GERMANS TRIAS | PUJOL
US_20260232732_A1

Absstract of: US20260232732A1

The present invention provides therapeutics for the treatment of CCR9-positive cancers such as T-cell acute lymphoblastic leukemia. In particular, the present invention provides a CCR9 targeting moiety. The present invention furthermore relates to a CCR9 targeting moiety comprising a further targeting moiety, preferably a CD1a targeting moiety, a dual CAR comprising a CCR9 and a CD1a targeting moiety, their use in the treatment of CCR9 and/or CD1a positive cancers, and the use of a CCR9 targeting moiety and a separate CD1a targeting moiety for such treatment.

ANTIBODIES TO GLYCOSAMINOGLYCANS

Publication No.:  US20260234243A1 13/08/2026
Applicant: 
ABIDEA INC [CA]
ABIDEA INC.
US_20260234243_A1

Absstract of: US20260234243A1

0000 Polyspecific anti-glycosaminoglycan (GAG) antibodies and methods of use thereof for directly killing cancer cells. The anti-GAG antibodies can be used for purging cancer cells from autologous stem cell transplants (ASCT) or autologous bone marrow transplants (ABMT). The cancer cells may be multiple myeloma, Hodgkin's lymphoma, neuroblastoma, or any other cancer that expresses a membrane-tethered heparan sulfate proteoglycan (HSPG), such as syndecan or glypican.

USE OF TELOMERASE INHIBITORS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS AND MYELOPROLIFERATIVE NEOPLASMS

Publication No.:  EP4789716A2 12/08/2026
Applicant: 
GERON CORP [US]
Geron Corporation
EP_4789716_A2

Absstract of: EP4789716A2

0001 Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have myelodysplastic syndrome. Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having myelodysplastic syndrome.

STRUCTURE-GUIDED ENGINEERING OF PEPTIDE-BASED NLRP3 INFLAMMASOME INHIBITORS FOR MYELODYSPLASTIC SYNDROMES (MDS)

Publication No.:  US20260226119A1 06/08/2026
Applicant: 
H LEE MOFFITT CANCER CENTER AND RESEARCH INST INC [US]
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
US_20260226119_A1

Absstract of: US20260226119A1

0000 Disclosed are compositions and methods for engineered peptide inhibitors of NLRP3 inflammasome and methods of their use in the treatment of Myelodysplastic Syndromes.

OPHTHALMIC FORMULATIONS OF METHOTREXATE

Publication No.:  US20260224578A1 06/08/2026
Applicant: 
ALDEYRA THERAPEUTICS INC [US]
Aldeyra Therapeutics, Inc.
US_20260224578_A1

Absstract of: US20260224578A1

0000 The present disclosure provides formulations of methotrexate for ocular administration, including intravitreal administration, and use of the formulations for treating proliferative vitreoretinopathy (PVR), intraocular lymphoma (e.g., PVRL), and intraocular inflammation.

Reverse Transcriptase Mutants with Increased Activity and Thermostability

Publication No.:  US20260226431A1 06/08/2026
Applicant: 
INTEGRATED DNA TECHONOLGIES INC [US]
Integrated DNA Techonolgies, Inc.
US_20260226431_A1

Absstract of: US20260226431A1

The disclosure provides Moloney murine leukemia virus (MMLV) reverse transcriptase (RTase) mutants. The disclosure as provides suitable amino acid positions in MMLV RTase for mutagenesis and methods and kits for using MMLV RTase mutants to synthesize cDNA from RNA templates.

NANOPARTICLES DIRECTED TO CXCR4 AND USE THEREOF

Publication No.:  US20260224733A1 06/08/2026
Applicant: 
TECHNION RES & DEVELOPMENT FOUNDATION LIMITED [IL]
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
US_20260224733_A1

Absstract of: US20260224733A1

0000 Nanoparticles comprising an outer surface covalently conjugated to 1,4-Bis(1,4,8,11-tetraazacyclotetradecan-1-yl)methylbenzene (AMD3100) or a derivative thereof capable of binding to C-X-C chemokine receptor type 4 (CXCR4) are provided. Methods for of treating a CXCR4 positive cancer, such as multiple myeloma or acute myeloid leukemia, in a subject in need thereof, methods of determining suitability for treatment and methods of covalently linking a molecule comprising a secondary amine to a lipid nanoparticle, are also provided.

MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF

Publication No.:  US20260226048A1 06/08/2026
Applicant: 
CHILDRENS HOSPITAL MEDICAL CENTER [US]
THE US SECRETARY DEPT OF HEALTH AND HUMAN SERVICES [US]
KUROME THERAPEUTICS INC [US]
CHILDREN'S HOSPITAL MEDICAL CENTER
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
KUROME THERAPEUTICS, INC
US_20260226048_A1

Absstract of: US20260226048A1

0000 Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I), (II), or (III)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

METHODS FOR TREATING NEUROBLASTOMA WITH A DUAL ANAPLASTIC LYMPHOMA KINASE AND FOCAL ADHESION KINASE INHIBITOR

Publication No.:  US20260224567A1 06/08/2026
Applicant: 
THE REGENTS OF THE UNIV OF MICHIGAN [US]
The Regents of the University of Michigan
US_20260224567_A1

Absstract of: US20260224567A1

0000 Provided herein are methods for treating neuroblastoma characterized as having genetic aberrations in ALK, FAK, and/or MYCN with ESK440.

TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH ANTIBODIES INHIBITING GALECTIN-9

Nº publicación: US20260226175A1 06/08/2026

Applicant:

PURETECH LYT INC [US]
PureTech LYT, Inc.

US_20260226175_A1

Absstract of: US20260226175A1

Disclosed herein are combined therapies for treating a hematologic malignancy (e.g., acute myeloid leukemia (AML), or myelodysplastic syndromes (MDS)), using an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g., G9.2-17), and one or more chemotherapeutics, e.g., a Bcl2 inhibitor such as venetoclax, a hypomethylating agent (HMA), or a combination thereof.

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