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FABRICATION OF ADDITIVELY MANUFACTURED OBJECTS WITH MECHANICALLY INTERLOCKING ELEMENTS

Absstract of: US20260048566A1

Materials and additively manufactured objects including mechanically interlocking elements are provided. In some embodiments, a method includes forming a dental appliance at least partially out of a composite material. The composite material can include an interlocking structure having a plurality of interlocking elements. The interlocking structure can have a first mechanical property. The composite material can also include a matrix surrounding at least a portion of the interlocking structure. The matrix can have a second mechanical property different from the first mechanical property.

MANDIBULAR RECONSTRUCTION SYSTEMS AND METHODS

Absstract of: US20260047933A1

Systems and methods for mandibular reconstruction are provided. An example system may comprise a drilling guide comprising: (1) a body configured to register against two adjacent surfaces of a native mandible when the body is temporarily secured to the native mandible; and (2) a tube extending from the body. The tube may be configured to constrain orientation of a drill bit when inserted through the tube and into the native mandible to reduce off-axis tilt of the drill bit when forming a void in the native mandible. Size and orientation of the void may correspond with size and orientation of a phalange of a neo-mandible assembly to be received within the void.

RUBBER KNEE REPLACEMENT APPARATUS AND METHOD FOR CUSTOMIZATION

Absstract of: US20260047936A1

A prosthetic knee replacement apparatus constructed of rubber avoids the disadvantages of metal prosthetics. The knee replacement apparatus includes a base member as a spacer between the upper and lower legs of a patient. A femoral portion extends upwardly from an upper surface of the base member and a tibial portion is coupled to a lower surface of the base member. The knee replacement apparatus may be constructed completely or substantially from a rubber material so as to reduce friction and degeneration. The knee replacement system may be constructed or even 3D printed after the leg bones of the patient are scanned.

MANDIBULAR RECONSTRUCTION SYSTEMS AND METHODS

Absstract of: US20260047934A1

Systems and methods for mandibular reconstruction are provided. An example neo-mandible assembly may comprise: (1) a first bone graft section; (2) a second bone graft section; (3) a tensioning plate; (4) a first dental implant that secures the first bone graft section to the tensioning plate; and (5) a second dental implant that secures the second bone graft section to the tensioning plate. The tensioning plate may hold the first bone graft section and the second bone graft section in fixed positions relative to each other. The first dental implant may comprise: (a) a dental screw that extends through an aperture of the tensioning plate and into the first bone graft section to secure the tensioning plate to the first bone graft section; and (b) a snap abutment attached to a head of the dental screw, wherein the snap abutment is configured to receive a dental implant.

VARIABLE THICKNESS DENTAL APPLIANCES AND ASSOCIATED METHODS

Absstract of: US20260047910A1

Dental appliances and associated methods are provided herein. In some embodiments, a dental appliance includes an appliance shell formed from a plurality of 3D printed polymer layers. The appliance shell can include a plurality of tooth receiving cavities arranged to receive a dentition and to exert one or more forces on the dentition, and a plurality of variable thickness regions integrally formed with the appliance shell as a single monolithic component. The plurality of variable thickness regions can include an upper thickened region at a first side of a tooth receiving cavity and a lower thickened region at a second side of the tooth receiving cavity opposite the first side. The upper and lower thickened regions can be configured to control movement of a tooth received within the tooth receiving cavity.

BONE FIXATION DEVICE

Absstract of: US20260047875A1

A bone fixation device (1) is presented, comprising a wire (7) and a load distributor (9), the load distributor comprising: a contact side (2) having a contact region (11) which is pressed against the bone to be fixed upon tightening of the wire (7), and two opposite lateral sides (4) that are not in contact with the bone upon tightening of the wire (7). At least one of the lateral sides (4) is provided with a plurality of recesses (5) which do not extend into the contact sides (2). The contact side (2) of the load distributor (9) has a continuous smooth surface which is configured to slide across the bone without damaging the bone when the load distributor (9) is pulled longitudinally across the bone during application.

THREE-DIMENSIONAL (3D)-PRINTABLE STRETCHABLE TRIBOELECTRIC NANOGENERATOR FIBERS

Absstract of: US20260051829A1

A fabrication process is disclosed for the production of flexible triboelectric nanogenerator (TENG) fiber, which can comprise a copper core surrounded by a silicone cladding. The TENG fibers are fabricated using a coaxial micro-extrusion process that enables 2D and 3D constructs to be fabricated with the fibers via 3D printing on both stationary and moving substrates to form mechanosensors as membranes, meshes, and hollow 3D structures. The mechanosensors can be integrated into wearable items for human activity monitoring, or can be formed on organs for organ monitoring, e.g., monitoring of perfused organs. The mechanosensors can be integrated into facemasks and uses for silent speech recognition, such as words mouthed in the absence of sound production by the speaker. The mechanosensors are self-powered and have high stretchability.

MUSCLE ASSISTANCE MEMBRANE

Absstract of: US20260048176A1

The invention relates to a muscle membrane intended to be affixed to a muscle of a human or animal body, the membrane being capable of at least partially surrounding the muscle, the muscle comprising fibres covered with an outer tissue, the positioned membrane having a shape that is identical to that of the muscle. The membrane is characterised in that it exhibits anisotropic behaviour so as to reproduce the mechanical behaviour of the muscle, the membrane comprising: -a matrix designed in a biocompatible material having an elasticity similar to that of the outer tissue of the muscle, -one or more reinforcing strips rigidly attached to the matrix, each strip being designed in a biocompatible material having an elasticity similar to that of the fibres it covers and each strip being oriented according to membrane stiffening requirements and according to the expected muscle correction.

THREE-DIMENSIONAL SCAFFOLD COMPOSITIONS AND METHODS FOR BONE REPAIR OR REGENERATION

Absstract of: US20260048175A1

Described herein are three-dimensional scaffold compositions and methods for bone repair or regeneration. In some embodiments, the disclosed scaffolds comprise a core portion mimicking a native trabecular bone structure that is surrounded by an exterior portion mimicking a native cortical bone structure. In some embodiments, the scaffolds may be functionalized by mineralization and/or pre-vascularization to promote bone and blood vessel formation.

PROCESS FOR THE MANUFACTURE OF A SOLID PHARMACEUTICAL ADMINISTRATION FORM

Absstract of: US20260048018A1

The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process that allows the production of a solid pharmaceutical solid administration form comprising an amorphous solid dispersion in an easy and flexible manner and the possibility to achieve fast disintegrating dosage forms with high drug loads.

Multi-Layer-Multi-Turn Structure For High Efficiency Wireless Communication

Absstract of: US20260051766A1

A structure for wireless communication having a plurality of conductor layers, an insulator layer separating each of the conductor layers, and at least one connector connecting two of the conductor layers wherein an electrical resistance is reduced when an electrical signal is induced in the resonator at a predetermined frequency. The structure is capable of transmitting or receiving electrical energy and/or data at various near and far field magnetic coupling frequencies.

METHOD AND SYSTEM TO CREATE CUSTOM PRODUCTS

Absstract of: US20260050182A1

Systems and methods for creating fully custom products from scratch without exclusive use of off-the-shelf or pre-specified components. A system for creating custom products includes an image capture device for capturing image data and/or measurement data of a user. A computer is communicatively coupled with the image capture device and configured to construct an anatomic model of the user based on the captured image data and/or measurement data. The computer provides a configurable product model and enables preview and automatic or user-guided customization of the product model. A display is communicatively coupled with the computer and displays the custom product model superimposed on the anatomic model or image data of the user. The computer is further configured to provide the customized product model to a manufacturer for manufacturing eyewear for the user in accordance with the customized product model. The manufacturing system is configured to interpret the product model and prepare instructions and control equipment for the manufacturing of the customized product.

FIXATION DEVICE FOR TRANSVERSE BONE DISTRACTION

Absstract of: US20260047867A1

In a particular embodiment, a fixation device (1) for transverse bone distraction comprising an elongated base (3) having a bone-remote top surface (5), a bone-facing bottom surface (7), a central section (9), a first end (11) and a second end (13), a first outer Schanz screw (15) attached to the first end (11) on the bottom surface (7) of the base (3), and a second outer Schanz screw (17) attached to second end (13) on the bottom surface (7) of the base (3), at least one inner Schanz screw (19) attached to the central section (9) on the bottom surface (7) of the base (3), and at least one displacement device (21) configured to move the at least one inner Schanz screw (19) away from the bone relative to the outer Schanz screws (15, 17).

MICRONEEDLES AND METHODS OF MANUFACTURE THEREOF

Absstract of: EP4696508A2

A microneedle array (105) for administration of a substance of interest into a biological tissue is provided. The array comprises a base substrate (110) having a microneedle side (115) and an opposing back side (120); a primary funnel portion (925, 1125) extending from the microneedle side (115) of the base substrate; and two or more solid microneedles (130) extending from the at least one primary funnel portion. The solid microneedles (130) comprise a substance of interest. A microneedle patch (100) is also provided, which includes the microneedle array (105) as well as an adhesive layer (135) and a handle layer (140) affixed to the base substrate and comprises a tab portion (150). The tab portion extends away from the solid microneedles and permits a person to manually hold the tab portion to manipulate the patch without contacting the solid microneedles. Also provided is a method for making an array of microneedles.

SUPPORT STRUCTURES FOR 3D PRINTED ORTHODONTIC DENTAL APPLIANCES AND MANUFACTURING METHODS THEREOF

Absstract of: US20260033918A1

The present disclosure provides a support of a 3D printed orthodontic dental appliance is provided. The orthodontic dental appliance includes a shell structure defined by an inner contour surface and an outer contour surface. The support comprises: a middle support including a middle support base mesh and a plurality of middle support struts and a main support configured to connect the middle support to a build platform of a 3D printing device used to print the orthodontic dental appliance. One end of each middle support strut of the plurality of middle support struts is connected to the orthodontic dental appliance at a junction of the inner contour surface and the outer contour surface, and the other end of the middle support strut is connected to a rim of the middle support base mesh.

SYSTEMS AND METHODS FOR DESIGNING OBJECTS

Absstract of: US2024342995A1

Systems and methods for designing additively manufactured objects are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, and determining a set of appliance parameters for a dental appliance configured to implement the treatment plan. The method can also include determining a set of manufacturing parameters for a fabrication system to be used to additively manufacture the dental appliance. The method can further include generating a 3D digital representation of an appliance geometry for the dental appliance. The appliance geometry can be configured to mitigate loss of fidelity at a target region of the dental appliance due to at least one manufacturing parameter of the fabrication system.

FISH GELATINE BASED HYDROGEL FORMULATION

Absstract of: EP4696337A1

The invention relates to an aqueous composition comprising thiolated and norbornene-modified cold-water species-derived gelatine. A further aspect of the invention relates to a method to generate a three-dimensional hydrogel object, particularly an in vitro model for disease modelling/drug testing or an implant, comprising providing a composition according to the invention and forming the hydrogel object by bioprinting (extrusion-based or digital light-based (DLP)) or molding/casting to provide the three-dimensional hydrogel object.Also provided are a hydrogel implant obtained by a method according to the invention, and a kit comprising dried thiolated and norbornene-modified cold-water marine species gelatine.

PRINTHEAD AND SYSTEM FOR ELECTROPORATION, AND METHOD OF PRINTING PATTERNED TISSUE

Absstract of: WO2024228814A2

A method of printing patterned tissue includes flowing a bioink comprising cells and a biological cargo through a nozzle moving relative to a substrate and exposing selected voxels of the bioink to a pulsed electric field as the bioink flows through the nozzle. Consequently, a portion or all of the cells in each of the selected voxels undergoes electroporation and transfection with the biological cargo. A cell-laden filament comprising the bioink and including the selected voxels is continuously extruded from an outlet of the nozzle, and, as the nozzle moves relative to the substrate, the cell-laden filament is deposited in a predetermined pattern on the substrate. Thus, a tissue having spatial patterns of gene expression may be printed.

一种生物仿生骨软骨生物电池及其制备方法和应用

Absstract of: CN121534223A

本发明提供了一种生物仿生骨软骨生物电池及其制备方法和应用，属于生物医用材料与组织工程技术领域。该生物电池包括阳极层、阴极层和隔膜层；所述阳极层由锌粉和水凝胶骨架组成，所述阴极层由二氧化锰粉和水凝胶骨架组成，所述隔膜层由聚偏氟乙烯粉和水凝胶骨架组成。本发明提供的生物电池能够模拟天然骨软骨组织电微环境与化学信号、具备仿生分层结构、并可实现程序化电刺激与离子释放。该电池不仅能提供稳定持久的内源性电刺激，还能引导内源性干细胞进行分区定向分化，从而实现骨软骨缺损的一体化、功能性再生。

为OSA症推荐治疗方案的系统、方法、设备及介质

Absstract of: CN121533835A

本发明提供了一种为OSA症推荐治疗方案的系统、方法、设备及介质，包括为初筛为OSA的患者进行口腔扫描，获取患者口腔数字印模；制取患者的牙齿印模；由所述口腔数字印模以及所述牙齿印模制作患者的预制口腔矫正器；采集患者在佩戴所述口腔矫正器时的第一睡眠监测数据，以及未佩戴所述口腔矫正器时的第二睡眠监测数据；对比所述第一睡眠监测数据以及所述第二睡眠监测数据，根据对比结果确定患者与口腔矫正器的适配性；根据患者与口腔矫正器的适配性为患者推荐合适的治疗方案。本发明能够解决OSA治疗成本高，治疗疗效不确切的技术问题。

Method for producing a multiphase polymer 3D gel dosimeter mimicking human tissues, soft, bone and lung, intended for radiotherapy treatment planning

Absstract of: PL449505A1

Przedmiotem zgłoszenia jest sposób wytwarzania wielofazowego polimerowego dozymetru żelowego 3D imitującego tkanki ludzkie, miękką, kostną i płucną, przeznaczonego do opracowania planu leczenia w radioterapii, z wykorzystaniem metody druku 3D polegającej na drukowaniu obiektu na podstawie jego modelu wirtualnego sporządzonego za pomocą programu komputerowego, poprzez wytwarzanie na podłożu bazowym za pomocą drukarki, której program sterujący jej pracą zawiera model wirtualny wytwarzanego obiektu, kolejnych warstw tego obiektu, jedna na drugiej z substratu do sporządzenia tego obiektu, aż do wytworzenia całego obiektu, który charakteryzuje się tym, że metodą druku 3D wytwarza się fazę dozymetru wielofazowego imitującą co najmniej jedną z tkanek tego wielofazowego dozymetru, na podstawie modelu wirtualnego drukowanej tkanki, który sporządza się na podstawie obrazów tkanki indywidualnego pacjenta, uzyskanych z tomografii komputerowej lub rezonansu magnetycznego, na podłożu bazowym ogrzanym do temperatury 50°C, z umieszczonego w dozowniku drukarki, zżelowanego roztworu dozymetrycznego do wytworzenia fazy wielofazowego polimerowego dozymetru 3D imitującej drukowaną tkankę. Roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitującej tkankę kostną, roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitującej tkankę miękką oraz roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitują

TRANSALVEOLAR DENTAL IMPLANT AND METHOD OF MANUFACTURE

Absstract of: EP4659703A2

The present disclosure relates to single tooth or full arch dental restoration. In cases where patients have insufficient bone stock for conventional root-form dental implants, current solutions often fail to restore function. The present disclosure describes a transalveolar dental implant for single tooth or full arch dental restoration. The transalveolar dental implant is comprised of a post and a bone plate, the bone plate having a contoured portion fabricated to match the topography of a bony surface of the facial skeleton. Through primary fixation of the contoured portion of the bone plate, the transalveolar dental implant improves function and outcomes in affected patients.

一种光固化生物墨水及其制备方法和应用

Absstract of: CN121513271A

本发明涉及一种光固化生物墨水及其制备方法和应用，属于生物材料及组织工程技术领域。该光固化生物墨水包括甲基丙烯酰化鱼鳞明胶和光引发剂，其中，甲基丙烯酰化鱼鳞明胶由鱼鳞明胶与甲基丙烯酸酐通过酰化反应制得，甲基丙烯酰化鱼鳞明胶的取代度为30%~55%。该光固化生物墨水兼具快速光固化、低免疫原性、低脂肪含量及优良生物相容性，特别适用于软骨、皮肤、血管等精细组织工程支架和类器官的3D生物打印构建。

用于微导管塑形的方法及相关产品

Absstract of: CN121515465A

本申请公开了一种用于微导管塑形的方法及相关产品，其中所述方法包括：控制塑形指对塑形丝实施塑形，以将所述塑形丝塑造成目标形状；在塑形过程中，对所述塑形嘴、所述塑形指以及所述塑形丝之间进行碰撞检测；根据碰撞检测结果确定相应的碰撞处理操作。通过本申请方法能够及时检测出碰撞并处理，进而避免造成不可逆的塑形错误。

负载生长因子的双层GelMA-AlgMA功能性水凝胶支架的制备及其应用

Nº publicación: CN121513272A 13/02/2026

Applicant:

深圳市第二人民医院（深圳市转化医学研究院）

Absstract of: CN121513272A

本发明公开了负载生长因子的双层GelMA‑AlgMA功能性水凝胶支架的制备及其应用。包括以下步骤：制备复合KGN的GelMA水凝胶前体溶液；制备复合 BMP‑2的AlgMA水凝胶前体溶液；3D打印。本发明的有益效果在于：将复合KGN的GelMA和复合 BMP‑2的AlgMA结合为双层支架，KGN促进软骨形成，BMP‑2促进骨形成，生长因子针对性地释放，针对骨软骨界面的不同组织层进行特异性修复。