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181
results.
Updated on
13/07/2025 [07:14:00]
Absstract of: CN120284553A
本发明提供了一种复合血管支架及其制备方法，涉及血管支架技术领域。本发明通过结合3D打印中的熔融沉积制造技术和层压制造技术制备聚合物/金属复合血管支架，利用FDM技术制备两层聚合物薄片，并在两层薄片间加入一层金属丝，随后通过加热加压工艺，使聚合物薄片之间紧密粘合并完全包覆金属丝，得到聚合物/金属正弦形片状结构，然后将聚合物/金属片弯折成管状结构，并将两端金属丝并拢后打结固定，得到复合血管支架。本发明的复合血管支架具有良好的径向支撑力，克服了现有含聚合物材料的复合血管支架的不足，能够满足临床使用对支架径向强度的要求。
Absstract of: CN120284897A
本发明提供了载枯草芽孢杆菌的3D打印多孔聚己内酯胶囊及其制备方法。所述胶囊包括壳层结构和由壳层结构包围而成的含有包裹物的腔体，所述壳层结构由外到内依次包括外壳层和透析膜层，所述包裹物为枯草芽孢杆菌；其中，所述外壳层的原料包括聚己内酯、聚乙烯、改性聚丙烯、热稳定剂；所述透析膜层的原料包括聚己内酯、聚乙烯醇抗氧化剂、增塑剂、热稳定剂；载枯草芽孢杆菌的3D打印多孔聚己内酯胶囊能摄取肠道内的锰离子，同时限制载枯草芽孢杆菌进入肠道，随后胶囊携带枯草芽孢杆菌和离子排出体外，能够有效降低人体内锰离子含量，有助于阻止白色脂肪向米色脂肪转变，抑制恶病质形成。
Absstract of: CN120285263A
本发明公开了一种3D打印外覆甲敷料的制备方法，制备用于甲床创伤的外覆甲敷料，具体步骤如下：步骤1：将热塑性生物相材料与抑菌材料混合，经干燥和熔融挤出制备得到复合线材；其中，所述热塑性生物材料为聚乳酸PLA、热塑性聚氨酯TPU、聚己内酯PCL或聚羟基脂肪酸酯PHA中的任意两种，且任意两种热塑性生物材料的质量比为(3～7)：(3～7)；抑菌材料为无机盐晶须，按质量百分比计算，抑菌材料的质量占热塑性生物材料总质量的百分比为0.5wt％～2wt％；步骤2：采用熔融沉积技术进行3D打印成型，得到所述外覆甲敷料。
Absstract of: CN120285289A
本发明属于生物材料及生物医学工程技术领域，特别涉及一种多功能交联双网络仿生水凝胶支架及其制备方法和应用。多功能交联双网络仿生水凝胶支架包括碳负载二氧化铈和钆离子交联双网络水凝胶，通过3D打印技术制备出具备梯度力学强度的钆离子交联双网络水凝胶支架。本发明的多功能交联双网络仿生水凝胶支架具有抗肿瘤、抗炎和仿生力学性能等特点，在体外和体内均展现了良好的抗炎、促成骨和促成软骨再生能力。在808 nm近红外(NIR)照射下表现出优异的光热性能，照射后，高温(高于45°C)可以用于抗肿瘤治疗，有效抑制肿瘤复发，而温和的温度则能促进软骨和骨的再生。本发明采用3D打印技术可实现对不规则缺损区域形状特异性、个性化的水凝胶支架打印。
Absstract of: CN120289716A
本申请公开了一种光固化树脂、制备方法及应用，属于光固化3D打印技术领域。本申请提供的光固化树脂包括聚氨酯丙烯酸酯低聚物、改性丙烯酸酯低聚物和活性稀释剂，其中，聚氨酯丙烯酸酯低聚物可以提高光固化树脂的韧性和反应速度，降低光固化树脂的体积收缩，改性丙烯酸酯低聚物可以提高光固化树脂的耐久性，调节硬度和韧性，同时降低光固化树脂的体积收缩，活性稀释剂可以提高光固化树脂的硬度和韧性；采用聚氨酯丙烯酸酯低聚物、改性丙烯酸酯低聚物和活性稀释剂复配，并限定各组分用量，使各组分充分发挥协同作用，从而使光固化树脂在具有较低体积收缩、较高硬度的同时保持高韧性与耐久性。
Absstract of: CN120284842A
本发明涉及一种盐酸右美托咪定微针，所述微针由载药针体层和基底层制成，其中，载药针体层：基底层的体积比为1:100‑200，载药针体层中由聚乙烯吡咯烷酮：盐酸右美托咪定按照质量比为1‑15:1制得，基底层由聚乙二醇二丙烯酸酯光交联制得。本发明的盐酸右美托咪定微针具有起效快速，药效维持时间长，对皮肤无刺激性并避免了感染风险，实现了盐酸右美托咪定的经皮精准给药，显著提高其生物利用度及用药的安全有效性。
Absstract of: CN120297073A
本发明涉及一种基于4D打印的膝关节矫形支具制备及驱动方法、支具结构，其中制备方法及驱动方法通过结合膝关节三维扫描体表数据和医学影像，建立具有膝关节畸形特征的生物力学模型，为打印支具提供模型基础，为驱动支具提供预测参数，提高支具实用性；其中支具结构包括第一矫形板和第二矫形板，并通过第一连板和第二连板连接，便于组装且穿戴后不影响行走；驱动方法包括利用具有膝关节畸形特征的生物力学模型，进而结合深度学习算法构建膝关节矫形目标角度预测模型，为矫形支具的各次形态改变提供参照，且模型可以根据具体阶段调整继续使用，提高效率，提高资源利用率。
Absstract of: CN120289180A
本发明公开了一种用于光固化3D打印的氧化锆膏料及其制备方法，其原料按重量份包括：氧化锆掺杂物：72％‑76％；光敏树脂预混液：12％‑14％；流变助剂：1％‑2％；分散剂：0.8％‑1.5％；消泡剂：0.05％‑0.1％；流平剂：0.05％‑0.1％；溶剂：10％‑12％；着色剂：0.3％‑0.6％；本发明涉及增材制造技术领域。该用于光固化3D打印的氧化锆膏料及其制备方法，通过三级级配的氧化锆掺杂物作为主体材料，在光敏树脂预混液、流变助剂、分散剂、消泡剂、流平剂和溶剂的配合下，确保各成分充分分散，为氧化锆膏料在3D打印成型过程中提供均匀稳定的保障，有效消除成品的表面和内部缺陷，并且利用着色剂模拟天然牙色，既具备良好的加工性能又拥有良好的力学性能、生物相容性以及美学效果。
Absstract of: CN120284580A
本发明涉及医疗器械技术领域，特别涉及一种基于3D打印的个性化口咽通气道装置。本发明的基于3D打印的个性化口咽通气道装置包括3D打印的咽通气道主体，所述咽通气道主体一端设有限位部，所述咽通气道主体的内壁上设有气流感应器，所述限位部上设有处理器、电源和通讯器，所述处理器分别连接所述电源、气流感应器和通讯器，所述电源连接所述通讯器。优点：结构设计简单、合理，装置根据患者的口咽形状个性化定制，佩戴更加舒适，同时，能够在OSA患者睡眠时，辅助打开气道，避免口腔内软组织堵塞气道，同时，能够实时监测气道的通畅情况，记录相关数据，帮助患者及医护人员了解睡眠呼吸状况，以便及时进行调整及救治。
Absstract of: WO2025147626A1
The present disclosure provides novel oligomer compounds (e.g., non-polar oligomers) that can produce desirable polymeric materials (e.g., with polar reactive diluents), polymer compositions, and/or photo-curable resins that have excellent stain resistance. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances with increased stain resistance.
Absstract of: US2025225754A1
A method for fabricating a custom cranial remodeling device for correction of cranial deformities in a subject is described. The method comprises generating a three-dimensional head data file for the subject and determining contour lines on the head. The method further comprises automatically generating a modified head shape data file. Still further the method includes utilizing the modified head shape data file to generate a shape for a desired custom cranial remodeling device and restricting growth of the head in first areas.
Absstract of: US2025221814A1
There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber: a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.
Absstract of: US2025221826A1
A process for printing a talus implant comprising the steps of scanning a joint for a damaged talus, and scanning a contralateral joint for a healthy talus. Next, the process includes obtaining dimensions for a talus based upon an initial scan and then obtaining dimensions for a talus based upon the scan of the contralateral joint. Next the process includes inverting the dimensions of the talus in the contralateral joint and then comparing the dimensions of the calculated talus with a pre-set of dimensions in a database. Next the process includes exporting a set of dimensions to a printer to print a talus implant.
Absstract of: US2025221824A1
A method of additive manufacturing an object featuring properties of a hard bodily tissue, comprises: dispensing and solidifying a plurality of non-biological material formulations to sequentially form a plurality of hardened layers in a configured pattern corresponding to a shape of the object. The method forms voxel elements containing different material formulations at interlaced locations to provide a three-dimensional textured region spanning over the portion. The material formulations and the interlaced locations are selected such that the textured region exhibits, once hardened, a stress variation of at most ±20% over a strain range of from about 0.1% to about 0.3%.
Absstract of: US2025221803A1
Provided herein are methods of making a coated object that include applying a coating composition to a surface of an object that comprises a plurality of entrapment structures thereon, wherein the coating composition is on at least a portion of the plurality of entrapment structures; and curing and/or solidifying the coating composition to form the coated object. Also provided are coated objects formed by such methods. Additionally, provided herein are methods of bonding a first surface to a second surface wherein the first surface and/or the second surface comprises a plurality of entrapment structures thereon. Composite articles are also provided herein.
Absstract of: US2025223568A1
Disclosed herein is a method of extracting extracellular matrix (ECM) from organoids via decellularization and hydrogels formed from methods thereof. The hydrogels can be used in medical devices for regenerative medicine like tissue grafts, and research and development applications to enhance disease modeling utilizing 3D bioprinting or other hydrogel embedding processes. The hydrogels can also be used to enhance tissue culture flasks for cells by offering a softer environment than polystyrene for cell culture. The hydrogels can be used in drug and vaccine delivery as well.
Absstract of: US2025222654A1
The method of manufacturing a transparent whitening tray according to the present invention includes 3D printing of the whitening tray using the composition for forming a transparent whitening tray as a raw material (S10), removing uncured resin and liquid from the whitening tray obtained in the above step (S20), post-curing the whitening tray obtained in the above step (S30), post-heat treating the whitening tray obtained in the above step (S40), and washing the whitening tray obtained in the above step (S40).
Absstract of: US2025222168A1
Described herein is a method of forming an aligned tissue or tissue construct. The method includes extruding a bioink material through a nozzle onto a support to form a structure of the bioink material, the bioink material comprising anisotropic organ building blocks (aOBBs) comprising extracellular matrix material (ECM) and cellularly aligned cells, wherein the aOBBs align parallel to the direction of the extrude path, and polymerizing the structure of the bioink material, thereby forming the tissue or tissue construct having arbitrarily programmed alignment. Also, described is a tissue or tissue construct produced by the method, as well as bioink material used to produce the same.
Absstract of: US2025222169A1
The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.
Absstract of: US2025225892A1
The present disclosure is directed to an artificial 3D scaffold of thyroid comprising artificial laryngeal and tracheal framework, wherein the scaffold comprises an artificial interstitial fluid sheath. Further, methods for obtaining a 3D scaffold according to the present disclosure and methods for identification of the recurrent laryngeal nerve in a subject, are disclosed.
Absstract of: US2025225755A1
Anatomical parts including surgical trainers and prosthesis and methods of creating three-dimensional anatomical parts by gathering three-dimensional image data from multiple sources, indexing characteristics from the data and then averaging the data to create new anatomical parts that have averaged characteristics. The disclosed methods also enable bonding of various materials through printed lattices.
Absstract of: US2025225753A1
A method for fabricating a custom cranial remodeling device for correction of cranial deformities in a subject is described. The method comprises generating a three-dimensional head data file for the subject and determining contour lines on the head. The method further comprises automatically generating a modified head shape data file. Still further the method includes utilizing the modified head shape data file to generate a shape for a desired custom cranial remodeling device and restricting growth of the head in first areas.
Absstract of: US2025222178A1
Methods for improving the antibacterial and/or bone-forming characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant may comprise a composite of a silicon nitride ceramic powder dispersed within a poly-ether-ether-ketone (PEEK) or a poly-ether-ketone-ketone (PEKK) substrate material. In some implementations, the biomedical implant may be 3D printed.
Absstract of: US2025222166A1
The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.
Nº publicación: EP4582433A1 09/07/2025
Applicant:
NAT UNIV PUSAN IND UNIV COOP FOUND [KR]
Pusan National University Industry - University Cooperation Foundation
Absstract of: EP4582433A1
The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.
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