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225
results.
Updated on
31/05/2025 [07:02:00]
Absstract of: CN222917965U
本实用新型涉及一种负压微针给药装置，包括：壳体，壳体的顶部设置有注射器接口，注射器接口用于连接外部的注射器；壳体的底部设置有凹槽和凸起，凸起用于和皮肤贴合；壳体的内部设置有储药腔体和负压腔体，储药腔体和注射器接口连通；壳体的表面设置有负压接口，负压腔体的一端通过负压接口和外部的抽负压装置连接；凹槽的表面设置有通孔，负压腔体的另一端通过通孔和外部连通；微针，包括针头和中空的流道，流道设置在针头的内部，流道和储药腔体连通，针头凸出于凹槽的表面向外延伸，针头用于刺破皮肤。本实用新型可以有效地吸引皮肤靠近针头并自动刺破皮肤给药，提高了给药效果和患者的使用体验。
Absstract of: US2024131795A1
Systems, methods, and devices for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, the treatment plan specifying a target arrangement for the teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method can include identifying appliance design parameters for one or more dental appliances to implement at least one treatment stage of the plurality of treatment stages. The appliance design parameters can include one or more manufacturability parameters corresponding to an additive manufacturing process to be used to directly fabricate the one or more dental appliances. The method can further include determining an appliance geometry for the one or more dental appliances using the set of appliance design parameters.
Absstract of: CN120053115A
本申请公开一种高适配的根形种植体，涉及牙种植体技术领域，包括：根形种植体；根形种植体的外形完全贴合拔牙窝；根形种植体的顶部开设有向内的凹槽；凹槽用于固定中央螺栓和义齿种植基台；根形种植体是基于目标口腔CT数据，采用3D打印制作；目标口腔CT数据为拔牙窝处的CT数据；凹槽是基于义齿种植基台和中央螺栓的底部形态，采用机件加工在根形种植体上制备。本申请中根形种植体能够适配安装不同类型的中心螺栓和义齿种植基台，同时该根形种植体的应用也能有效地缩短牙种植手术的周期时间。
Absstract of: CN120053764A
本发明涉及软骨‑骨一体化类器官及其制备方法。所述软骨‑骨一体化类器官包括仿骨层与仿软骨层，所述仿骨层由基于压电水凝胶构建的仿骨基质力响应性生物墨水打印而成，所述仿软骨层由基于压电水凝胶构建的仿软骨基质力响应性生物墨水打印而成。本发明将压电材料与生物墨水相结合，利用3D生物打印技术精确构建软骨层和骨层的双生态位结构。通过压电材料将机械力转化为生物电信号，从而促进细胞活动和组织再生。同时，3D生物打印技术实现精确的结构控制，为关节软骨缺损修复提供了一种全新的策略。
Absstract of: CN120056233A
本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；将着色溶液喷射打印(S102)至一个或多个层上；以及施加(S103)用于固定着色溶液的固定溶液。
Absstract of: CN120056234A
本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；以及将半透明度增强剂和/或不透明度增强剂喷射打印(S102)至一个或多个层上。
Absstract of: CN120053751A
本发明属于生物材料技术领域，具体涉及一种骨修复用3D打印聚乳酸复合支架及其制备方法。其中，骨修复用3D打印聚乳酸复合支架由以下原料制备而成：PLA/Mg‑ZrO2和BP/STAC；本发明采用PLA/Mg‑ZrO2作为3D打印支架，在PLA/Mg‑ZrO2支架表面形成BP/STAC复合涂层，制备得到骨修复用3D打印聚乳酸复合支架，PLA/Mg‑ZrO2支架具有模仿天然骨骼的分级孔隙率，PLA具有良好的生物相容性，Mg‑ZrO2的加入增强了PLA支架的力学强度和韧性，BP/STAC的复合涂层进一步增强了复合支架的力学性能，且有助于细胞附着和生长，加速了骨细胞的增殖和分化，促进新骨的形成。
Absstract of: CN120053748A
本发明公开一种骨修复支架及其制备方法与应用。所述骨修复支架由磷酸镁支架在钾盐溶液中养护而成，磷酸镁支架的原料包括磷酸三镁和打印墨水载体，磷酸三镁为三水磷酸氢镁和氢氧化镁，打印墨水载体由明胶溶液、甘油和戊二醛溶液制得。所述骨修复支架的制备方法包括：用三水磷酸氢镁和氢氧化镁制备磷酸三镁粉末；将明胶水溶液、甘油、戊二醛溶液混合均匀，得到打印墨水载体；将磷酸三镁粉末与打印墨水载体混合，并进行垂直沉积3D打印，得到磷酸镁支架；将磷酸镁支架置于磷酸氢二钾溶液中养护，得到磷酸镁骨修复支架。本发明提供的骨修复支架，能够达到力学强度高、孔隙率高的效果。
Absstract of: CN120055291A
本发明提供一种新型钛钽合金牙科种植体材料及其制备方法和应用，该制备方法包括以下步骤：S1.准备钛钽合金粉末，按质量百分比计包括以下元素成分：Ta：30‑50％、余量为Ti，待用；S2.建立牙科种植体三维模型，使用选择性激光熔化将S1所述钛钽合金粉末制备得到目标，所述3D打印激光功率为200‑350W，扫描速度为600‑800mm/s，层厚为20‑40μm，得到牙科种植体，待用；S3.对S2所得牙科种植体进行等离子体表面处理，功率为100‑300W，时间为10‑20min，即得所述新型钛钽合金牙科种植体材料。所得新型钛钽合金牙科种植体材料具有较低的弹性模量、优异的力学性能和生物相容性，能促进细胞增殖，显著改善了种植体的生物力学性能，兼顾耐用性和减轻应力屏障效应，特别适用于高要求临床场景。
Absstract of: CN120053753A
本发明公开了一种基于3D打印的复合人工骨及其制备方法。复合人工骨的制备方法包括步骤：(1)将聚己内酯和磷酸钙混合并制为丝材；(2)按照预设模型，使用所述丝材打印成型得到3D打印多孔支架，所述多孔支架具有孔道结构；(3)将填充浆料注入所述多孔支架的孔道结构中，所述填充浆料含有胶原蛋白和磷酸钙，干燥，获得成型的复合人工骨；(4)将复合人工骨和交联剂进行化学交联，交联后清洗，干燥，获得复合人工骨产品。该复合人工骨具有较优的力学强度，可以有效促进大段骨缺损、骨不连治疗过程中的早期血管及新骨生长。
Absstract of: CN120056235A
本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印来生产牙科修复体100的方法，包括以下步骤：借助于陶瓷浆料喷射打印(S101)牙科修复体的一个或多个层；以及将着色溶液喷射打印(S102)至一个或多个层上。
Absstract of: CN120056314A
本申请涉及一种精确压低前牙的正畸矫治器的制作方法及正畸矫治器，精确压低前牙的正畸矫治器的制作方法包括根据数字化牙颌模型至少确定覆颌数值、覆盖数值和咬合平面，以及根据覆颌数值确定的需求压低量；确定预设覆盖阈值，根据预设覆盖阈值和覆盖数值之间的第一对比结果，确定对应的压低平台类型；确定预设压低量，根据预设压低量和需求压低量的第二对比结果，确定是否执行分阶段压低操作，若执行分阶段压低操作，则确定分阶段压低操作中的每个阶段压低量，分阶段压低量能基于用户交互窗口进行动态调整。不仅可以针对不同覆颌程度的患者提供个性化的矫治方案，还能确保压低量的精确控制，从而避免传统方法中因压低不准导致的反复调整问题。
Absstract of: CN120053114A
本申请公开了一种仿生型种植桥架，属于种植桥架领域。仿生型种植桥架包括种植体和连接体；种植体包括多个，每个种植体适配一个人体常规牙齿形状；多个种植体按人体常规牙齿顺序排列，相邻两个种植体之间通过连接体连接；每个种植体从牙尖至牙根的方向由实体结构向第一多孔结构变化以使弹性模量降低；每个种植体从牙齿中心至边沿的方向通过增加孔隙率使弹性模量降低；通过降低孔隙率使作为切牙、尖牙和磨牙的种植体的牙本质的弹性模量依次增加。本申请在采用同一种材料制作仿生型种植桥架的同时，实现根据人体生理牙齿不同位置具有不同的弹性模量，与人体生理牙齿实际弹性变形情况一致化，具有仿生学设计。
Absstract of: CN120056232A
本发明涉及通过喷射打印生产牙科修复体的方法、装置和系统。本发明提供一种通过喷射打印生产牙科修复体的方法，包括以下步骤：使用具有彼此不同颜色的多种不透明陶瓷浆料来喷射打印(S101)牙科修复体的牙本质核；以及使用半透明陶瓷浆料来喷射打印(S102)牙科修复体的牙齿釉质。
Absstract of: US2025172541A1
Embodiments pertain to a bioink operational to form an artificial bone. The bioink includes a plurality of bone-related cells. Additional embodiments pertain to an artificial bone that includes a plurality of bone-related cells; and a bioink of the present disclosure that is embedded with the cells. The artificial bone may be in the form of a three-dimensional structure that includes a plurality of channels operational to allow fluid flow through the artificial bone. Further embodiments pertain to methods of making an artificial bone by applying a plurality of bone-related cells and a bioink onto a surface such that the bioink becomes embedded with the cells and forms a three-dimensional structure with a plurality of channels.
Absstract of: EP4559600A1
An inorganic structure having mechanical properties that differ depending on the region in the inorganic structure, and a method for manufacturing the inorganic structure are provided. An inorganic structure (1) of the present embodiment includes a plurality of solidified portions (SA) composed of an inorganic material. The plurality of solidified portions (SA) include a first solidified portion (SA1) having a first crystallographic direction (CO1) preferentially oriented in a predetermined direction, and a second solidified portion (SA2) having a second crystallographic direction (CO2) that is a different orientation from the first crystallographic direction (CO1).
Absstract of: CN119584936A
The present invention relates to a curable composition comprising: a (meth) acrylate free of urethane moieties, a urethane (meth) acrylate, a photoinitiator, discrete filler particles having an average particle size in the range of 10 nm to 40 nm and having been surface treated with a silane surface treatment agent, the silane surface treatment agent is selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both, and the discrete filler particles are present in an amount of 20% by weight or more, the curable composition further comprising an additive selected from the group consisting of silane surface treatment agents comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, silane surface treatment agents not comprising (meth) acrylate moieties, and mixtures of both. The curable composition does not contain, in each amount of 2 wt% or more, aggregate of nano-sized particles, fumed silica, wt% relative to the curable composition, alone or in combination: aggregate of nano-sized particles, aggregate of nano-sized particles, fumed silica.
Absstract of: WO2024017906A1
The present invention concerns a composition which is a hydrogel comprising, in an aqueous medium: - at least one hydrophilic thickening polymer, and - particles of eggshell membrane, in an amount of less than 5% by weight of the total weight of the composition, wherein said particles are rod-shaped, needle-shaped or fibrous, having a specific particle size. It also relates to a bioink comprising said composition, to a method for manufacturing a 2D or 3D product using said hydrogel, to a kit comprising said hydrogel or bioink, and to uses thereof.
Absstract of: CN120036789A
本发明公开了一种用于脑电监测的半干电极及其制备过程，包括外壳、外壳顶部、电极触角、电解液缓释体和电极芯，其中电极触角包括弹簧触角和中空触角；电解液缓释体采用导电海绵、导电水凝胶或导电纤维织物等材料，确保电解液的均匀释放；制备方法采用三维建模与3D打印技术，精确控制电极形状和尺寸，降低生产成本并缩短制备时间。本发明利用弹簧触角和中空触角的组合结构提高接触时的稳定性。本发明的脑电半干电极为脑电监测过程中提供了一种更舒适可控的解决方案，通过压力调节电解液流速，同时弹簧触角缓冲接触压力，提高佩戴舒适性，能够提高信号质量，增强使用者的佩戴体验。
Absstract of: CN120046438A
本发明公开了一种椎间融合器的制备方法、对应模型的生成方法及其装置，该生成方法包括：接收患者病变部位的医学影像数据，生成患者的目标骨器官的装配模型；生成装配模型对应的有限元仿真装配模型，生成应力云图；将椎间融合器原始模型转变成隐式体，在隐式体的空间中填充随机种子；在隐式体中添加随机种子点；在隐式体中将随机种子之间生成连线，从而在隐式体中生成三维晶格，三维晶格即为椎间融合器模型。该生成方法能够根据椎间融合器在宿主体内所受应力，从而智能化驱动椎间融合器多孔结构排布，精准降低椎间融合器应力屏蔽效应。
Absstract of: WO2024079567A1
A dental appliance for a patient includes a body including a first surface and a second surface opposite to the first surface. The second surface defines a channel for receiving a plurality of teeth of the patient. The dental appliance further includes an arrangement of a plurality of features disposed on the first surface of the body. Each of the plurality of features includes a protrusion extending from the first surface opposite to the second surface; a depression extending partially from the first surface towards the second surface; or a through-hole extending from the first surface to the second surface. The arrangement of the plurality of features encodes a feature data representative of a dental appliance information of the dental appliance or a patient information of the patient.
Absstract of: CN120048175A
本发明公开了一种唇腭裂畸形矫正术训练模型及其制造方法。本发明中，通过精确的CT扫描和高级的三维重建技术，结合SLA 3D打印技术，能够直接从数字模型一步到位打印出唇腭裂畸形矫正术训练模型。这种一次成型的好处在于，它避免了传统制造方法中可能出现的多步骤组装和接合的复杂性和误差。每个模型都是一体成型的，确保了模型的准确性和结构的完整性。这种方法通过使用高级的材料和精细的3D打印技术，该方法能够制造出外观和质感都非常接近真实人体唇腭裂皮肤软组织的训练模型。这种模型的皮肤软组织部分具有与真实组织相似的弹性、质地和颜色，使得外科医生在进行手术训练时能够获得更加真实和直观地体验。
Absstract of: US2024051246A1
Methods for manufacturing objects are provided herein. In some embodiments, a method includes receiving a dental appliance formed using an additive manufacturing process, the dental appliance including a plurality of appliance portions. The method can include identifying, based on sensor data, a location of a subset of the appliance portions on the dental appliance. The method can further include applying energy to a subset of the appliance portions to selectively modify one or more material properties of the subset of the appliance portions.
Absstract of: CN120038939A
本发明属于3D打印技术领域，具体涉及一种低浓度胶原蛋白的低温DLP 3D打印方法及其应用。本发明首次意外发现在pH 3体系下可以显著提高光敏胶原蛋白ColMA生物墨水的打印性能，通过低温DLP 3D打印得到持久性的高活性胶原蛋白生物支架；相较于高浓度GelMA支架，所述低浓度ColMA生物支架具有更高的机械性能，更短的平衡溶胀时间、更低的溶胀比、更强的抗降解能力，以及更高的生物活性，可以显著促进人包皮成纤维细胞的增殖、粘附、迁移以及向肌成纤维细胞的分化，有效缓解大鼠全层皮肤损伤处炎症反应、促进伤口再上皮化和胶原有序沉积，加快全层皮肤损伤再生，在组织再生工程中具有广泛的应用前景。
Nº publicación: CN120051272A 27/05/2025
Applicant:
默克专利股份公司
Absstract of: WO2024038000A1
The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process that allows the production of a solid pharmaceutical solid administration form comprising an amorphous solid dispersion in an easy and flexible manner and the possibility to achieve fast disintegrating dosage forms with high drug loads.
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