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3D bioprinting

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LastUpdate Updated on 26/07/2025 [07:27:00]
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多功能牙科装置及相关方法

Publication No.:  CN120379615A 25/07/2025
Applicant: 
福塞特加藤国际控股有限公司
CN_120379615_PA

Absstract of: WO2023222193A1

The invention relates to a series (100) of devices for incrementally modifying the position of the teeth in a person (P), said series comprising at least two devices (10), the devices (10) each comprising at least one jaw device (11, 12), the at least one jaw device (11, 12) being designed in such a way that receiving regions of the jaw device (11, 12) can be placed on a dental arch of the upper jaw (OK, 5) or of the lower jaw (UK, 4) of the person (P), the devices (10) being designed such that, when worn according to a predefined order of said devices (10), they incrementally progressively modify the position of the teeth owing to mechanical interaction between the device and at least one tooth element. The at least one jaw device (11, 12) of the first device (10.1, 10.2) may carry, on its outer side, a first veneering element (N.I.1.2, N.IV.1.2) as a partial region of the first device (10.1, 10.2). The at least one jaw device (11, 12) of the second device (10. n) may carry, on its outer side, a second veneering element (N.I.1.n, N.IV.1.n) as a partial region of the second device (10). The first veneering element (N.I.1.2, N.IV.1.2) may be located at the same position as the second veneering element (N.I.1.n, N.IV.1.n) according to a dental notation. A receiving region of the first veneering element (N.I.1.2, N.IV.1.2) may have a different design and/or position than a receiving element of the second veneering element (N.I.1.n, N.IV.1.n), this difference being capable of cau

一种双相生物活性组织修复支架及制备方法

Publication No.:  CN120365051A 25/07/2025
Applicant: 
四川大学
CN_120365051_PA

Absstract of: CN120365051A

本发明公开了一种双相生物活性组织修复支架及制备方法,包括以下步骤:步骤1:磷酸钙陶瓷粉体进行表面改性,得到改性后的磷酸钙陶瓷粉体;步骤2:将改性后的磷酸钙陶瓷粉体、铌酸钾钠压电陶瓷粉体、分散剂、光引发剂、光敏树脂充分混合均匀,球磨后得到光固化树脂浆料;步骤3:按照设计构建3D打印模型,将光固化树脂浆料按照3D打印模型打印即可得到支架坯体;步骤4:支架坯体经清洗、脱脂烧结即可得到所需支架;本发明能够制备兼具良好的力学性能、高效抗肿瘤能力及较好的促骨再生能力的双相生物活性组织修复支架,为临床上骨肿瘤术后骨缺损的修复提供技术支持。

一种蛋白纳米纤维复合类血管及其制备方法与应用

Publication No.:  CN120361299A 25/07/2025
Applicant: 
华南理工大学
CN_120361299_PA

Absstract of: CN120361299A

本发明公开了一种蛋白纳米纤维复合类血管及其制备方法与应用,属于3D打印类血管结构技术领域。本发明首先通过AF和GelMA的氢键相互作用,构建了含有纳米蛋白纤维的凝胶墨水,然后通过嵌入式3D打印方法,利用AF和HA的正负离子相互作用和基质相中引发剂向墨水相中的渗透作用,经过紫外光化学交联和后处理,构建了微观尺度上含有纳米蛋白纤维,宏观尺度上壁厚可调的类血管结构。该类血管结构微观尺度上可模拟细胞外基质微环境的纳米纤维结构,宏观尺度上可模拟人体不同部位血管的壁厚,为体外构建血管样结构提供了一种新策略。

一种基于数字化技术的治疗义齿制作方法

Publication No.:  CN120360726A 25/07/2025
Applicant: 
重庆晶美医疗科技有限公司
CN_120360726_PA

Absstract of: CN120360726A

本发明公开了一种基于数字化技术的治疗义齿制作方法,其包括:通过扫描获取患者的口腔数据及颌位关系,根据扫描获得的口腔数据及颌位关系设计上颌义齿和下颌义齿;通过3D打印制成上颌基托实体、上颌牙列实体、下颌基托实体和下颌前牙实体;用粘接剂将上颌牙列实体粘接在上颌基托实体上形成上颌义齿实体,用粘接剂将下颌前牙实体粘接在下颌基托实体上形成下颌义齿实体;向下颌基托实体上的凹槽中填充材料形成树脂平板;对树脂平板进行修正,直至上颌义齿实体与下颌义齿实体建立正确的咬合关系。本发明采用数字化设计与3D打印相结合的方式,制作流程短,能显著缩短治疗义齿的制作周期;且制成的治疗义齿实体和所设计的数字化治疗义齿的一致性高,减少了认为误差。

用于制造生物打印纤维结构的系统和方法

Publication No.:  CN120379823A 25/07/2025
Applicant: 
安斯百克特生物系统公司
CN_120379823_PA

Absstract of: MX2024014120A

Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

DUAL CROSSLINKED SILK-BASED MATERIALS FOR IN SITU DEPOSITION OR PRINTING

Publication No.:  WO2025155859A1 24/07/2025
Applicant: 
TRUSTEES OF TUFTS COLLEGE [US]
TRUSTEES OF TUFTS COLLEGE
WO_2025155859_PA

Absstract of: WO2025155859A1

Disclosure herein concerns a non-crosslinked composition having capacity for double crosslinking. The non-crosslinked composition includes a population of methacrylate-modified silk fibroin fragments, each of the methacrylate-modified silk fibroin fragments comprising methacrylate side chains, a photo-crosslinker, an enzymatic crosslinker and optionally one or more enzymatic crosslinker co-reactants, and water

METHOD AND DEVICE FOR MANUFACTURING TRANSPARENT ORTHODONTIC DEVICE, AND RECORDING MEDIUM

Publication No.:  WO2025155025A1 24/07/2025
Applicant: 
OSSTEMIMPLANT CO LTD [KR]
\uC624\uC2A4\uD15C\uC784\uD50C\uB780\uD2B8 \uC8FC\uC2DD\uD68C\uC0AC
WO_2025155025_PA

Absstract of: WO2025155025A1

Disclosed are a method, a device performing the method, and a recording medium, the method comprising the steps of: obtaining, by a processor, specification information about a plurality of standard pre-aligners, which is generated on the basis of statistical information; obtaining, by a reception unit, oral information about a user; determining, by the processor, one of the plurality of standard pre-aligners on the basis of the oral information and the specification information; obtaining, by the processor, a tooth model corresponding to the oral information; and deforming, by the processor, the determined standard pre-aligner to correspond to the tooth model so as to obtain a transparent orthodontic device corresponding to the tooth model.

LINKAGE APPARATUS FOR PRINTER, PRINTER, AND MEDICAL APPARATUS

Publication No.:  US2025235165A1 24/07/2025
Applicant: 
GE PREC HEALTHCARE LLC [US]
GE Precision Healthcare LLC
CN_120348083_PA

Absstract of: US2025235165A1

Embodiments of the present application provide a linkage apparatus for a printer, a printer, and a medical apparatus. The linkage apparatus comprises: a paper compartment assembly, provided with a side opening, a base, a paper tray located in the base, and a paper advancing member disposed opposite the side opening, an end of the paper advancing member opposite the side opening being provided with an advancing plate extending upward; a door assembly, movably connected to the paper compartment assembly and capable of closing or opening the side opening; and a transmission mechanism, one side of which is connected to the door assembly, the transmission mechanism driving the paper advancing member to move toward the side opening along with opening of the door assembly, causing the paper advancing member to, by means of the advancing plate, advance paper in the paper tray to move toward the door assembly.

METHOD FOR PRODUCING CELL-BASED FISH CONTAINING FISH MUSCLE SHAPE-MIMICKING MUSCLE USING 3D BIOPRINTING TECHNOLOGY AND CELL-BASED FISH PREPARED THEREBY

Publication No.:  US2025234907A1 24/07/2025
Applicant: 
BAOBAB HEALTHCARE INC [KR]
Baobab healthcare Inc
KR_20240051567_PA

Absstract of: US2025234907A1

Provided are a method for producing an edible cell-based fish that can realize actual fish muscle shape and texture, and a cell-based fish prepared thereby. The method for producing cell-based fish containing fish muscle shape-mimicking muscle using 3D bioprinting technology includes the steps of: mixing cells for cultured fish and an edible bioink; printing the cell printing ink in a fish muscle-mimic pattern to form a laminated structure; adding a crosslinking agent to the laminated structure; and culturing the laminated structure to which the crosslinking agent is added into a fish muscle tissue.

LIGHT THERAPY LOUNGER AND METHOD OF MANUFACTURING THEREOF

Publication No.:  US2025235717A1 24/07/2025
Applicant: 
ENERGY LOUNGER LLC [US]
ENERGY LOUNGER LLC

Absstract of: US2025235717A1

Embodiments of the present invention disclose a light therapy lounger. The light therapy lounger includes a frame including a peripheral wall and an inward protrusion extending internally from an inner surface of the peripheral wall. Further, the light therapy lounger includes a plurality of irradiation boards located on the inward protrusion and including a plurality of irradiation sources. Also, the light therapy lounger includes an upper cover made up of a diaphanous material, the upper cover configured to be located above the plurality of irradiation boards. Each irradiation board includes one or more pressure sensors and several irradiation sources electrically coupled to a first Printed Circuit Board (PCB), a heat sink thermally coupled to the first PCB and located under the first PCB, and a plurality of cooling fans electrically coupled to the first PCB and/or a second PCB, and located under the heat sink.

SYSTEMS AND METHODS FOR MODIFYING SURFACES OF ADDITIVELY MANUFACTURED OBJECTS

Publication No.:  EP4587222A2 23/07/2025
Applicant: 
ALIGN TECHNOLOGY INC [US]
Align Technology, Inc
CN_120202085_PA

Absstract of: US2024091906A1

Systems and methods for processing additively manufactured objects are described herein. In some embodiments, for example, a system includes a controller configured to provide one or more control signals; a heater coupled to the controller, where the heater comprises one or more heating elements arranged to heat a blasting medium in response to the one or more control signals; a chamber coupled to the controller, where the chamber comprises an agitatable drum shaped to receive a plurality of additively manufactured objects, and to agitate the plurality of additively manufactured objects in response to the one or more control signals; and an applicator coupled to the controller, where the applicator comprises a nozzle operative to direct, in response to the one or more control signals, a plurality of thermally conductive particles in the blasting medium toward the plurality of additively manufactured objects within the agitatable drum.

三维打印牙模

Publication No.:  CN223126679U 22/07/2025
Applicant: 
上海普利生三维科技有限公司
CN_223126679_U

Absstract of: CN223126679U

本申请提供了一种三维打印牙模,包括:主体部,所述主体部的底部位于第一平面内,并且所述底部为开放式,所述主体部的内部具有容纳腔,所述主体部具有外壁;支撑部,位于所述容纳腔内,所述支撑部在所述第一平面上的投影为蜂窝状,并且所述支撑部具有沿垂直于所述第一平面的第一方向从所述底部延伸到所述外壁的支撑壁;其中,所述支撑壁在所述第一方向上至少部分的厚度小于所述外壁的厚度。

一种时空间声学超材料贴片及其制备方法与应用

Publication No.:  CN120346464A 22/07/2025
Applicant: 
南京鼓楼医院
CN_120346464_PA

Absstract of: CN120346464A

本发明公开了一种时空间声学超材料贴片及其制备方法与应用,包括自下而上依次设置的压电基底、聚焦声波换能器以及声学阻抗匹配层;所述的聚焦声波换能器为两对以上的叉指电极对,各叉指电极对能够通过交频信号各自激活并产生聚焦声场;所述的声学阻抗匹配层为通过光刻打印逐层光交联的微米尺度锥形结构阵列,能够实现声学传感器和组织的阻抗匹配。本发明利用多重叉指电极具有时空间聚焦超声能量的功能,而且声学阻抗匹配层可以更好的传递声波能量和装载各种治疗功能的活性物质,从而实现低温伤口的热、炎症、和愈合多重管理。这种基于声学超材料为基础的贴片具有多功能、数字化可控、精准治疗、方便可靠等优点。

一种骨科医用3D打印锌基球形粉末及制备方法

Publication No.:  CN120347202A 22/07/2025
Applicant: 
广东省科学院新材料研究所
CN_120347202_PA

Absstract of: CN120347202A

本发明提供一种骨科医用3D打印锌基球形粉末及制备方法,属于金属粉末材料与制备技术领域,包括:制备符合成分要求的锌基金属熔体;将所述锌基金属熔体引流至高速旋转的圆盘中心,旋转加速后,分裂、成球、冷却、凝固,得到锌基球形粉末料;将所述锌基球形粉末料进行筛分,即得所述锌基球形粉末。通过选定锌基金属,并结合改进后的旋转圆盘,制备出高品质骨科医用3D打印锌基球形粉末,所制备出的3D打印锌基球形粉末空心粉率降低至1%以内,粉末球形度高,粉末粒径的D90与D10之差小于10µm,粉末利用率可达90%以上。

一种3D打印三叉神经痛球囊压迫穿刺导板

Publication No.:  CN223126615U 22/07/2025
Applicant: 
自贡市第三人民医院
CN_223126615_U

Absstract of: CN223126615U

本实用新型涉及医用辅助器械,一种3D打印三叉神经痛球囊压迫穿刺导板,包括导板本体和导向管;所述导向管与导板本体之间通过支撑悬臂连接,所述导向管为半圆管状。本实用新型采用半圆管形式的导向管,其在穿刺完成后,能够方便快速的与穿刺器械进行分离,穿刺完成无需再进行导向时,可以在不抽出穿刺器械的基础上实现导向管与穿刺器械的快速脱离,降低了穿刺导板本身造成的术野干扰和操作干扰。

生物墨水制造装置

Publication No.:  CN120359055A 22/07/2025
Applicant: 
浦项控股股份有限公司浦项产业科学研究院浦项工科大学校产学协力团
CN_120359055_PA

Absstract of: WO2024128661A1

A bioink manufacturing device is provided. The bioink manufacturing device according to the invention includes: a reaction container for reacting a decellularized xenogeneic organ tissue with an inkification solution, a bioink liquefaction unit for stirring and crushing the decellularized xenogeneic organ tissue to liquefy same into bioink, and a bioink discharge unit for discharging the liquefied bioink outside of the reaction container.

3D打印金属植入物

Publication No.:  CN223111858U 18/07/2025
Applicant: 
绵阳市第三人民医院
CN_223111858_U

Absstract of: CN223111858U

本实用新型公开了3D打印金属植入物,包括植入物主体。本实用新型通过采用了顶部件、中部件、底部件,作业时,通过3D打印机可以分批次的将顶部件、中部件以及底部件进行3D生产出来,接着将生产出来的多组部件可以通过底部的限位环与顶部的定位槽进行对接就可以实现多组结构的初步连接操作,接着转动结构可以使得孔洞相互对齐,然后在孔洞中安装上紧固螺栓,通过紧固螺栓就可以实现多组结构的固定操作,由于构成植入物主体的结构采用模块化的设置,因此在生产过程中容错率大幅度提升,可以在某一部件出现不合格时针对性的进行替换生产,不需要整个结构进行重新生产,有效的提升了整体的使用灵活性以及实用性,具有生产容错率高、使用灵活的优点。

基于人工智能的髓腔固位冠制造方法、系统

Publication No.:  CN120326941A 18/07/2025
Applicant: 
苏州派克顿科技有限公司
CN_120326941_PA

Absstract of: CN120326941A

本发明涉及牙冠制造技术领域,具体涉及基于人工智能的髓腔固位冠制造方法、系统,基于人工智能的髓腔固位冠制造方法包括:获取口腔CBCT影像与口扫模型;将口腔CBCT影像与口扫模型合成为合成模型;将合成模型输入训练后的AI模型,由AI模型基于合成模型生成髓腔固位冠模型;对髓腔固位冠模型做模拟受力测试,当髓腔固位冠模型的任意区域的应力大于预定值时,重新生成髓腔固位冠模型;对模拟受力测试合格的髓腔固位冠模型做模拟试戴测试;根据模拟试戴测试的结果调整髓腔固位冠模型;将调整后的髓腔固位冠模型输入打印装置并打印生成半成品髓腔固位冠;对半成品髓腔固位冠进行固化处理,生成成品髓腔固位冠。本申请提高了患者体验。

一种FARSs的数字化设计及制作方法及FARSs

Publication No.:  CN120324131A 18/07/2025
Applicant: 
同济大学
CN_120324131_A

Absstract of: CN120324131A

本发明公开了一种FARSs的数字化设计及制作方法及FARSs,该方法包括:获取使用者静态的上下颌牙列数字化三维模型、颌骨数字化三维模型及下颌动态运动数据,并在CAD/CAM软件内进行拟合,以构建使用者的动态VDP模型;基于使用者的动态VDP模型,确定使用者的治疗颌位,并导出对应于各治疗颌位的数字化三维牙列模型;依据所导出的各治疗颌位对应的数字化三维牙列模型,在CAD/CAM软件内中完成牙合面具有解剖形态的FARSs的个性化设计;根据个性化FARSs的设计数据,使用3D打印技术一次性完成FARSs的制造。本发明制作的FARSs通过全数字化流程制作,相比传统前伸再定位咬合板,个性化位置精度高,贴合性好,舒适度高,可以改善咀嚼功能;其次,序列治疗降低治疗难度、减少患者复诊次数。

纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用

Publication No.:  CN120326930A 18/07/2025
Applicant: 
常德市第一人民医院
CN_120326930_PA

Absstract of: CN120326930A

本发明公开了纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用,其中,纳米羟基磷灰石/聚酰胺66复合材料的成型方法,包括:成型,采用熔融沉积成型的挤出式3D打印机对含纳米羟基磷灰石/聚酰胺66复合材料的料浆进行3D打印成型,得到打印件;后处理,对所述打印件依次进行干燥和退火,得到纳米羟基磷灰石/聚酰胺66复合材料的成型件。本申请利用3D打印可基于患者CT数据的三维重建技术可定制椎体假体形态,实现与复杂解剖结构的精确匹配,避免标准化椎体假体的局限性;还能够精确设计孔隙结构,而羟基磷灰石本身具备微观孔隙结构(<10μm),从而使产品具备多级孔隙结构,有利于加速骨整合。

一种具有活性的骨缺损修复材料及其制备方法

Publication No.:  CN120324678A 18/07/2025
Applicant: 
中科之光生物科技(河北省)有限公司
CN_120324678_PA

Absstract of: CN120324678A

本发明公开了一种具有活性的骨缺损修复材料及其制备方法。所述骨缺损修复材料由动物来源提取的胶原蛋白、煅烧骨基质及骨形态发生蛋白复合微球复合,通过光固化3D打印技术成型制成。本发明从仿生角度出发,拟以胶原蛋白作为框架材料,以免疫原性低的煅烧骨基质作为硬质材料增强材料力学支持,并辅以骨形态发生蛋白复合微球协同作用,长效引导未分化间充质干细胞向特定方向发展。该活性骨缺损修复材料,植入骨缺损部位后,为细胞提供一个利于细胞粘附和增殖微观环境,同时骨形成发生蛋白的缓慢释放,能够长效作用于骨缺损部位,有效地推动成骨细胞分化成熟的过程,促进骨缺损部位的骨修复。

光硬化性組成物及び歯科用製品

Publication No.:  JP2025107275A 17/07/2025
Applicant: 
三井化学株式会社
JP_2025107275_PA

Absstract of: JP2023143923A

To provide a photocurable composition which can yield a cured product with the suppressed formation of cracks and breaks and excellent handleability.SOLUTION: A photocurable composition includes a (meth)acrylic monomer component and a photopolymerization initiator, wherein the adhesive force of its cured product is less than or equal to 1.5 N, and the rupture elongation of the cured product is greater than or equal to 20%.SELECTED DRAWING: Figure 1

光開始剤、それを含むバイオインク及びハイドロゲルの製造方法

Publication No.:  JP2025107169A 17/07/2025
Applicant: 
プサンナショナルユニバーシティインダストリー-ユニバーシティコーポレーションファウンデーション
JP_2025107169_PA

Absstract of: US2025222169A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

Surgical Implant And Methods Of Additive Manufacturing

Publication No.:  US2025228594A1 17/07/2025
Applicant: 
K2M INC [US]
K2M, Inc
US_2023293208_PA

Absstract of: US2025228594A1

A method of manufacturing a surgical implant includes simultaneously forming a first component and a second component of the surgical implant. Formation of the first and second components includes depositing a first quantity of material to a building platform and fusing the first quantity of material to form a first layer of the first and second components. The method of manufacturing also includes depositing a second quantity of material over the first layer of the first and second components and fusing the second quantity of material to form a second layer of the first and second components. The surgical implant is fully assembled upon the completion of the formation of the first and second components.

3D PRINTED ARTIFICIAL BILE DUCTS AND MANUFACTURING METHOD THEREOF

Nº publicación: US2025229006A1 17/07/2025

Applicant:

IUCF HYU INDUSTRY UNIV COOPERATION FOUNDATION HANYANG UNIV [KR]
PASAN NATIONAL UNIV INDUSTRY UNIV COOPERATION FOUNDATION [KR]
IUCF HYU INDUSTRY UNIV COOPEATION FOUNDATION HANYANG UNIV [KR]
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY),
PASAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION,
IUCF-HYU (INDUSTRY-UNIVERSITY COOPEATION FOUNDATION HANYANG UNIVERSITY)

Absstract of: US2025229006A1

The present invention relates to an artificial bile duct comprising ursodeoxycholic acid (UDCA), and due to comprising UDCA, the artificial bile duct of the present invention is effective in improving differentiation into cholangiocytes and preventing formation of bile stones.

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