3D bioprinting

一种3D打印卷绕式骨修复支架的批量制备方法

Absstract of: CN122353908A

本发明属于生物医用材料与骨组织工程技术领域，特别提供了一种3D打印卷绕式骨修复支架的批量制备方法，包括如下步骤，S1：复合材料的制备；S2：制备适用于三维打印的丝材、颗粒料、浆料;S3:多孔片材三维打印；S4：热软化卷绕定型；S5:切段；S6:支架后处理。本发明适用于多种可降解高分子/生物活性无机复合材料体系，在相关材料及流程共同作用下，通过三维打印精确控制支架孔径、孔隙率与空间结构，兼容丝材挤出、颗粒直挤及浆料直写等多种打印供料形式，经“长条多孔片材→卷绕定型→轴向切段”的工艺实现了小型骨支架标准化批量生产，具有孔隙结构可控性好、适合多种打印供料形式、批量化生产效率高、支架结构有利于骨再生、材料体系灵活的优点。

一种即时混合调色喷墨3D打印方法及在义齿制备中的应用

Absstract of: CN122353909A

本发明公开了一种即时混合调色喷墨3D打印方法及在义齿制备中的应用，属于3D打印技术领域。该方法包括：制备添加有磁性颗粒的多种颜色墨水；构建颜色色值‑墨水比例数据库；根据目标颜色检索数据库，确定所需墨水的比例配方；按配方将不同颜色墨水喷射至对应单元；通过磁场驱动磁性颗粒运动，使各颜色墨水即时充分混合，实现精确调色；最后固化成型。本发明通过在墨水中引入磁性颗粒并结合外部动态磁场，解决了喷墨3D打印中多色墨水难以在微米级空间内即时、均匀混合的技术难题。该方法尤其适用于制备具有空间全向、连续自然颜色梯度的义齿，显著提升美学效果。

一种脊柱矫形测量装置

Absstract of: CN122350686A

本发明涉及脊柱矫形技术领域，特别是涉及一种脊柱矫形测量装置。该装置包括支撑立板、电机丝杆导轨、支撑臂、电动线性模组、靠背板及测力组件，支撑立板上设限位开关，电动线性模组驱动靠背板升降，配合可调扶手实现患者姿态限位；电机丝杆导轨、手动丝杆导轨及螺纹丝杆协同调节测力传感器位置，精准对位脊柱待测点；装置可精准采集矫形力数据并传输至外部系统，为个性化脊柱矫形器设计生产提供实测依据。本装置定位精准、测力可靠，适配不同体型患者，操作便捷，有效提升青少年特发性脊柱侧凸矫形测力精度与效率。

带过滤的液滴输送装置

Absstract of: WO2025122635A1

An aerosol delivery device including a liquid supply, an electronically actuated droplet ejector in fluid communication with the liquid supply, and filter media or inertial filter points between the ejector and a droplets outlet to reduce the droplet size distribution of ejected droplets to smaller droplets exiting the droplets outlet.

一种磷酸钙-聚己内酯复合材料支架及其制备方法与应用

Absstract of: CN122351600A

本发明提供了一种磷酸钙‑聚己内酯复合材料支架及其制备方法与应用，其中磷酸钙‑聚己内酯复合材料的制备原料包括聚己内酯、β‑磷酸三钙和羟基磷灰石，所得到的复合支架具有促免疫和调控骨再生的功能。本发明的磷酸钙‑聚己内酯复合材料支架的制备方法是先形成羟基磷灰石/聚己内酯复合薄膜，经破碎后与β‑磷酸三钙再度形成复合溶液的方式，所得到的3D打印复合支架不仅具有良好的机械强度和生物相容性，还同时具有诱导干细胞增殖和成骨分化、诱导巨噬细胞的再生分型极化的功能，可用于调控免疫细胞反应，诱导产生有利于骨生成的骨免疫微环境，进而提升骨再生效果，可用于组织缺损的修复和再生。

一种选区激光熔化的镁合金输尿管支架及制备方法

Absstract of: CN122351603A

本发明涉及医疗器械技术领域，公开了一种选区激光熔化的镁合金输尿管支架及制备方法，包括多孔网状结构，支架表面生成有一层均匀致密的磷酸镁转化膜。支架由选区激光熔化专用镁合金复合粉末制成，粉末由钇、钆、钕、锌、锰、锆和高纯镁原料制成。制备方法包括建立患者三维模型并切片处理；采用复合粉末逐层铺粉并熔化得到毛坯；将毛坯分离并进行打磨；打磨后置于热处理炉中依次进行固溶处理和时效处理；浸没于磷酸水溶液中发生钝化反应原位生成转化膜，最后灭菌包装。通过基体成分设计配合选区激光熔化成型技术与表面钝化膜处理，获得了降解速率可控、抗结壳且具备初期力学支撑能力的镁合金输尿管支架。

具有多层级梯度氮化钛耐磨陶瓷层的钛合金关节植入体及其制备方法

Absstract of: CN122351574A

本发明公开了一种具有多层级梯度氮化钛耐磨陶瓷层的钛合金关节植入体及其制备方法，方法包括对植入体表面进行清洁打磨，并采用三维光学扫描轮廓生成路径；在氮气‑氩气混合气氛箱内，通过分阶段调控激光功率、扫描速度、光斑尺寸及氮气体积分数等工艺参数，利用激光重熔扫描依次构建成分梯度过渡层、深度重熔强化层、浅度重熔强化层及表面致密耐磨层，实现从钛合金基体到表层氮化钛陶瓷的成分、组织与性能连续梯度分布的一体化原位合成。本发明可在保留骨接触面仿生多孔结构的同时，在关节摩擦面形成厚度约200μm、显微硬度≥25GPa、表面粗糙度Ra＜0.2μm的高结合强度梯度氮化钛陶瓷层，显著提升植入体的耐磨性、生物相容性与长期服役稳定性。

一种基于冷冻3D打印的多孔聚醚醚酮/陶瓷复合材料及其制备方法

Absstract of: CN122356557A

本发明提供了一种基于冷冻3D打印的多孔聚醚醚酮/陶瓷复合材料及其制备方法，将PEEK粉末与陶瓷粉末均匀分散于溶剂中，形成复合浆料；将复合浆料在低温冷冻平台上逐层打印，形成以冰晶为模板的预制体；随后经冷冻干燥移除冰晶，再通过程序化的热处理使PEEK颗粒固结，最终获得具有预设三维多孔结构的复合支架。本发明利用冷冻打印过程中冰晶的定向生长与升华，一步成型高精度、高连通性的仿生多孔结构，并实现了陶瓷材料在PEEK基体中的均匀、稳固复合，使支架同时具备较大的孔隙率和良好的力学性能，解决了传统高温发泡加工无法兼容热敏感陶瓷、以及多孔结构调控精度不足的问题。该制备工艺灵活，适用于制造个性化多孔结构与材料。

3D PRINTING OF POROUS MICROFLUIDIC DRUG DELIVERY SYSTEMS

Absstract of: WO2026146019A1

The invention relates to 3D-printed controlled-release solid oral pharmaceutical compositions comprising a hydrophobic matrix comprising cavities filled with air, allowing flotation in the stomach, one or more regions within the matrix comprising a pharmaceutical, one or more regions within the matrix comprising a swellable material, wherein optionally the one or more regions within the matrix comprise a swellable material and a pharmaceutical one or more fracture zones within the matrix with weaker or less dense structure, one or more hydrophilic channels within the matrix fluidly connecting the outside of the composition with a region within the matrix comprising the swellable material or the pharmaceutical.

METHODS AND SYSTEMS FOR DYNAMIC CORONARY ROADMAPPING

Absstract of: US20260191490A1

Methods and systems are provided for dynamically visualizing an object of interest that includes part of the vasculature of a patient, which employ a 3D model of the object to generate at least one roadmap that includes information that characterizes properties of the object (such as centerlines, contours, and an image mask. Reference location(s) corresponding to the roadmap(s) are determined for an interventional device used to treat the object. In an online phase, non-contrast-enhanced x-ray image data of the object are obtained and processed to determine location of the interventional device in the image data, and a particular roadmap is selected or accessed. The reference location corresponding to the particular roadmap and the determined location of interventional device are used to transform the particular roadmap. A visual representation of the transformed roadmap is overlaid on the image data for display.

MULTIVALENT POLYESTER BASED POLYURETHANE ACRYLATE OR METHACRYLATE OLIGOMERS FORMULATED WITH DIFFERENT REACTIVE DILUENTS

Absstract of: WO2026147879A1

The present disclosure provides novel oligomers and polymerizable compositions comprising the same. Further provided herein are methods of producing polymers, polymer coatings, and devices. Also provided herein are methods of using polymer materials and polymer materials fabricated via additive manufacturing processes (e.g., via 3D printing), such as orthodontic appliances.

SCALABLE FLUIDIC DEVICES FOR HIGH-THROUGHPUT ENRICHMENT AND SEPARATION OF CHARGED SPECIES AND METHODS OF USE

Absstract of: US20260192217A1

The present disclosure relates generally to fluidic devices for high-throughput removal of charged particles from a fluid, for example contaminants from drinking water or contaminants from spent dialysate. The fluidic devices comprise a flow-through 3D ion selective structure within a channel for focusing charged particles along an electric field gradient at the boundary of an ion depleted zone and/or in an ion enriched zone created by the 3D ion selective structure, thereby removing said charged particles from the fluid flowing through the 3D ion selective structure.

SYSTEM FOR CREATING HUMAN TISSUE SAMPLES THROUGH THREE-DIMENSIONAL BIOPRINTING AND CULTURING

Absstract of: WO2026147958A1

This document relates to devices, systems, and methods for fabricating a three-dimensional sample of human tissue. For example, this document relates to techniques for depositing cells according to a predefined pattern and treating the deposited cells to simulate a realistic human tissue sample.

HUMAN BODY MOTION GAIT ANALYSIS USING LIDAR-BASED 3D GAIT MEASUREMENTS

Absstract of: US20260191430A1

In certain implementations a computer-implemented method, computer program product and systems for performing gait analysis using lidar based three dimensional measurements is provided. Embodiments of the present invention can identify at least one object from received video information. Embodiments of the present invention can then estimate points on the object to depict two dimensional and three dimensional poses of the object based on a threshold number of frames depicting the object. Based on the estimated three dimensional poses, embodiments of the present invention can then generate measurements for biomechanical parameters that characterize movement of the object based on the estimated points on the object.

DELAYED-RELEASE ORAL DRUG DOSAGE FORM AND PREPARATION METHOD THEREFOR

Absstract of: WO2026145785A1

A delayed-release oral drug dosage form, and a preparation method related to the oral drug dosage form, such as a three-dimensional printing method.

SYSTEMS AND METHODS FOR MONITORING OXIMETRY PARAMETERS OF TISSUE

Absstract of: US20260191440A1

A system for detecting oximetry parameters of a user may include a reusable, wireless, and flexible near-infrared spectroscopy (NIRS) monitoring wearable system. The NIRS system may include a first component having a plurality of light sources configured to emit visible and infrared light at a plurality of wavelengths. The first component may have a first detector configured to detect a first plurality of signals from the plurality of light sources at a first source-detector distance of approximately 6 millimeters (mm) to 10 mm. The NIRS system may include a second component having a plurality of second detectors configured to detect a second plurality of signals from the plurality of light sources at multiple source-detector distances ranging from about 25 mm to about 45 mm. The NIRS system may include a memory, rechargeable battery, and processor configured to execute multi-depth tissue analysis.

SYSTEM AND METHODS FOR A LABOR COACH ALGORITHM

Absstract of: US20260191458A1

0000 Methods and systems are provided for receiving labor-related data for one or more previous contractions of a patient, the labor-related data at least comprising data obtained with one of a tocodynamometer, an IUPC, and an EHG recording system, predicting labor-related data for a next contraction based on the labor-related data for one or more previous contractions, generating one or more visual indicators and one or more audio indicators based on output from a labor prediction model, the output from the labor prediction model being generated by entering the received labor-related data for the one or more previous contractions into the labor prediction model, the predicted labor-related data, and user input into the labor prediction model, and displaying the one or more visual indicators to a display device that is visible to the patient and outputting the one or more audio indicators to the patient.

EMERGENCY ALERT MANAGEMENT

Absstract of: US20260191454A1

Systems and methods to improve resource utilization in ambulatory patient monitoring are disclosed, including detecting a critical event using the physiologic information, transitioning the ambulatory medical device from a long-term ambulatory monitoring mode to a critical response mode, and controlling, in the critical response mode, transmission of an advertising packet and information about the detected critical event to a remote device in a continuous listening mode or transition of a communication circuit of the ambulatory medical device to a listening mode to receive an advertising packet of the remote device in a continuous advertising mode to transmit a connection response and information about the detected critical event to the remote device to improve resource utilization of the ambulatory patient monitoring.

SYSTEM AND METHOD FOR PROVIDING A DISCRETE WORKSPACE

Absstract of: US20260195728A1

This application describes systems and methods for locating, securing, accessing and utilizing a discrete enclosure or workspace. The discrete enclosure or workspace may be located in a public, private or semi-private setting and may comprise a combination of working platforms or surfaces, seats, desks and other apparatus, as well as computer hardware and software. Systems may comprise natural language processing, artificial intelligence, machine learning and other adaptive learning capabilities to enhance the use of the discrete workspace. The workspace may be dimensioned to be used for a wide variety of activities by one or more users.

SYSTEMS AND METHODS FOR TRAINING MACHINE LEARNING MODELS FOR USE IN A PLURALITY OF SENSORY MONITORING DEVICES

Absstract of: US20260191463A1

0000 Methods and systems for receiving, by at least one processor, for each of a plurality of subjects at defined time intervals during a medical procedure, a subject-specific sensory metric output and a subject-specific sensor dataset. The subject-specific sensory metric output is outputted by a first sensory-monitoring device (SMD) of a first SMD type. The subject-specific sensor dataset is outputted by sensors monitoring a body of each subject from the plurality of subjects, and to be utilized by a second SMD of a second SMD type. The at least one processor executes code to correct for data collection deficiencies, to generate a training dataset for training a machine learning model (MLM) based on the subject-specific sensory metric output and a corrected subject-specific sensor dataset, to train the MLM, and to provide the trained MLM to the second SMD to facilitate medical actions during subsequent medical procedures.

AUTOMATING HIGH QUALITY RADIOTHERAPY PLANNING AT SCALE

Absstract of: US20260192132A1

0000 Systems and methods for generating radiotherapy plans are provided. One or more medical images are received. One or more anatomical objects are segmented from the one or more medical images. Radiotherapy configurations for one or more objectives are determined based on the one or more medical images and the segmentations of the one or more anatomical objectives. A candidate radiotherapy plan is generated based on the radiotherapy configurations. A quality assessment of the candidate radiotherapy plan is performed. The one or more objectives are updated based on results of the quality assessment and the determining, the generating, and the performing are repeated for one or more iterations using the updated one or more objectives as the radiotherapy objectives to generate the candidate radiotherapy plan for a last iteration as a final radiotherapy plan. The final radiotherapy plan is output. Since the pipeline is automatic, the plan generation can be scaled. The data can serve large-scale AI model training.

SUPPORT MATERIAL FORMULATIONS USABLE IN ADDITIVE MANUFACTURING AND METHODS EMPLOYING SAME

Absstract of: WO2026146504A2

A curable formulation usable as a support material formulation in additive manufacturing of a three-dimensional object such as a denture structure, which forms a hardened mixed layer with a modeling material formulation and provides an object that features improved toughness (e.g., fracture toughness), and additive manufacturing methods employing same are provided. The curable formulation comprises at least one non-curable material which comprises at least one polymeric material featuring water solubility (e.g., ECAH) lower than 200 grams/liter, at least one mono-functional (meth)acrylate featuring low Tg and miscibility in the non-curable material, at least one multi-functional (meth) acrylate featuring at least 10 ethoxylated groups and/or Tg lower than 0 °C, and at least one mono-functional (meth)acrylate. Additive manufacturing of a three- dimensional assembly which comprises a hardened object and a hardened sacrificial structure, and systems employing same are also provided.

SYSTEM AND METHOD FOR TITRATING BASAL INSULIN DOSES

Absstract of: US20260192048A1

0000 A continuous glucose monitor (CGM)-driven basal insulin titration system and method for patients with Type 2 Diabetes can be adapted to the needs and concerns of subjects just starting on basal insulin therapy. The method uses as inputs historical CGM data, basal insulin dose information, reports of hypoglycemia, and past recommendations and generates an adjusted insulin dose along with a report advising whether to continue the titration process, or to stop. The method can generate a new recommendation on a regular basis (e.g., each day) until it determines an adequate, consistent dose size.

BILDGESTÜTZTE STEUERUNG DES ENDOSKOP-RÜCKZUGS

Absstract of: DE112024003806T5

Es werden Systeme, Vorrichtungen und Verfahren zur Erstellung und Verwendung eines personalisierten, segment-spezifischen Endoskop-Rückzugsplans zur Steuerung eines endoskopischen Eingriffs offenbart. Ein Endoskopiesystem umfasst ein Endoskop und eine Steuerschaltung. Das Endoskop umfasst ein Bildgebungssystem zur Erfassung von Bildern oder Videodatenströmen einzelner anatomischer Segmente eines Patienten während eines endoskopischen Eingriffs. Die Steuerschaltung kann die Bilder oder Videodatenströme analysieren, um Bild- oder Videomerkmale für einzelne der unterschiedlichen Segmente der Anatomie zu generieren. Basierend auf den Bild- oder Videomerkmalen kann die Steuerschaltung einen Endoskop-Rückzugsplan generieren, der Ziel- oder empfohlene segment-spezifische Endoskop-Rückzugs-Parameterwerte für jedes der Segmente enthält. Der Endoskop-Rückzugsplan kann dem Benutzer oder einem Robotersystem bereitgestellt werden, um den manuellen oder robotergestützten Rückzug des Endoskops zu erleichtern.

SPATIAL AND CHARACTERISTIC PROPERTY DATA TO DETECT A SOURCE IN A SYSTEM

Nº publicación: US20260191456A1 09/07/2026

Applicant:

BIRED IMAGING INC [US]
BIRED Imaging, Inc.

Absstract of: US20260191456A1

Processes, algorithms and techniques are disclosed for detecting the presence of a source of at least one of heat, mass, momentum, energy, electrical field, and species in a system, such as, for identifying the presence of a heat source and its 3D location within a body part, and also to identify absence of a heat source within the body part. Multi-view thermal images are obtained of the body part and thermal and spatial information in different views are obtained. Iterative algorithms are developed to determine the presence of a heat source in the body part by employing the Physics-Informed Neural Network analyzer. Methods of generating a spatial-point-cloud and thermal-spatial-point-cloud are disclosed.