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3D bioprinting

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LastUpdate Updated on 19/05/2024 [07:23:00]
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假体衬垫和用于制造其的增材制造系统、方法及相应部件

Publication No.:  CN118055842A 17/05/2024
Applicant: 
奥索冰岛有限公司
CN_118055842_PA

Absstract of: US2023115195A1

An additive manufacturing system and method for making components having filaments formed by elastomeric materials. A liner includes the filaments formed by an elastomeric material and is adapted for a prosthetic device system. The filaments form an elastomeric lattice structure and solid layers or features and define a ventilated structure permitting a transfer of air and moisture from an interior volume of the liner to an exterior or ambient liner. The liner may incorporate an adhesive and a textile layer secured to the elastomeric lattice structure and further define recesses and other features for improving a liner.

一种无托槽矫治器配合下的正畸正颌终末合板及制备方法

Publication No.:  CN118044898A 17/05/2024
Applicant: 
中国人民解放军空军军医大学
CN_118044898_PA

Absstract of: CN118044898A

本发明公开了一种无托槽矫治器配合下的正畸正颌终末合板及制备方法,属于骨性畸形治疗结构的技术领域,包括马蹄形合板,马蹄形合板包括导板上颌面、导板下颌面、导板唇外侧和导板唇内侧,且导板上颌面和导板下颌面之间的距离为整个牙冠高度的三分之二,通过本发明,实现了在正畸正颌联合治疗的术后一到两个月内,可以对颌位起到固定的作用,同时包绕牙面的三分之二和无托槽隐形矫治器附件,起到正畸保持器的作用,有效的防止牙齿在拆除合板到开口两指的期间,出现了牙齿移位的情况,保证了矫治器的正常佩戴,方便患者自行佩戴,且避免医用级光敏树脂材料的特性而造成佩戴困难的问题。

DYNAMIC HYDROGEL COMPOSITIONS

Publication No.:  WO2024102853A1 16/05/2024
Applicant: 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV [US]
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
WO_2024102853_PA

Absstract of: WO2024102853A1

Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.

METHOD OF A VIBRATOR MANUFACTURE ACCORDING TO A REAL MASTER AND A PRODUCT OBTAINED USING THIS METHOD

Publication No.:  WO2024099485A1 16/05/2024
Applicant: 
SEVERSKY JIRI [CZ]
SEVERSK\u00DD, Ji\u0159\u00ED
WO_2024099485_PA

Absstract of: WO2024099485A1

A method of manufacturing of a vibrator according to a real master, comprising non-invasive, contactless and convenient home 3D scanning of the penis shape and subsequent manufacturing of its faithful replica in an industrial manner, including a step consisting 3D scan of a master of a penis using a mobile device, usually mobile phone or tablet, wherein the 3D scan of the master is created using available application software. The scanning is performed by convenient use of the LiDAR system and/or that the 3D model of the master is formed using image sensors, either with ToF (Time of Fly) technology or a photogrammetry - a method consisting of a 3D model composition from input 2D photographs. Conveniently, it comprises the step wherein the data are exported to an STL format that is directly applicable in conventional 3D printing. The invention is applicable in manufacturing of sexual aids and - as a product - in particular as a sexual aid/erotic toy.

LOAD-CARRYING ROD

Publication No.:  WO2024100147A1 16/05/2024
Applicant: 
SPINESAVE AG [CH]
SPINESAVE AG
WO_2024100147_PA

Absstract of: WO2024100147A1

A load-carrying rod (1) for an implant system has a structure of individual interconnected solidified droplets (4) so that the transitions from one droplet to another act as crack stoppers in the event of a crack.

A 3D PRINTABLE PIEZOELECTRIC PLATONIC SOLIDS FOR OMNIDIRECTIONAL ULTRASONIC POWERING OF MINIATURE IMPLANTS

Publication No.:  WO2024102992A2 16/05/2024
Applicant: 
KIM ALBERT [US]
KIM, Albert
WO_2024102992_A2

Absstract of: WO2024102992A2

A device comprising a piezoelectric solid and a miniaturized electronic device; wherein the piezoelectric solid comprises a polymer and metal oxide nanoparticles and has a platonic solid shape; wherein a face of the piezoelectric solid comprises a concentric void; and wherein the miniaturized electronic device is placed inside the concentric void.

A DETACHABLE PRINTHEAD FOR A BIOPRINTER AND A BIOPRINTER

Publication No.:  WO2024098119A1 16/05/2024
Applicant: 
INVENTIA LIFE SCIENCE PTY LTD [AU]
INVENTIA LIFE SCIENCE PTY LTD
WO_2024098119_PA

Absstract of: WO2024098119A1

A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.

METHOD OF PRINTING A HYDROGEL SCAFFOLD

Publication No.:  AU2022379458A1 16/05/2024
Applicant: 
LUNG BIOTECHNOLOGY PBC
LUNG BIOTECHNOLOGY PBC
AU_2022379458_PA

Absstract of: AU2022379458A1

A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold, and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.

CONTINUOUSLY BIOPRINTED MULTILAYER TISSUE STRUCTURE

Publication No.:  US2024158758A1 16/05/2024
Applicant: 
ASPECT BIOSYSTEMS LTD [CA]
ASPECT BIOSYSTEMS LTD
EP_4130243_A1

Absstract of: US2024158758A1

Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.

SOLID DOSAGE FORM PRODUCTION

Publication No.:  US2024156739A1 16/05/2024
Applicant: 
UNIV OF CENTRAL LANCASHIRE [GB]
University of Central Lancashire
US_2024148657_A1

Absstract of: US2024156739A1

The present invention utilizes 3D printing technology, specifically fused filament fabrication (FFF) 3D printing, to produce solid dosage forms, such as pharmaceutical tablets. The production process utilizes novel printing filaments, typically on a spool, which contain the active ingredient. Such active-containing filaments have proved to be extremely robust and the principles outlined in the present disclosure provide access to a variety of viable formulations directly from a 3D printer. This, for the first time, affords a viable means for the in situ (e.g. within a pharmacy) 3D printing of personalized medicines tailored to a patient's needs. The invention also relates to purpose-built software for operating the printing apparatus, as well as local, national and global systems for monitoring the real time operation of a plurality of printing apparati to enable facile detection of malfunctions, thereby making regulatory approval viable and facilitating regulatory compliance.

METHOD FOR MANUFACTURING DENTAL IMPLANT COMPONENTS

Publication No.:  US2024157651A1 16/05/2024
Applicant: 
BIOMET 3I LLC [US]
BIOMET 3I, LLC
US_2022016843_A1

Absstract of: US2024157651A1

A method for making a rapid prototype of a patient's mouth to be used in the design and fabrication of a dental prosthesis. The method takes an impression of a mouth including a first installation site having a dental implant installed in the first installation site and a gingival healing abutment having at least one informational marker attached to the dental implant. A stone model is prepared based on the impression, including teeth models and model markers indicative of the at least one informational marker. The model is scanned. Scan data is generated from the scanning. The scan data is transferred to a CAD program. A three-dimensional model of the installation site is created in the CAD program. The at least one informational marker is determined to gather information for manufacturing the rapid protocol. Rapid prototype dimensional information is developed. The rapid prototype dimensional information is transferred to a rapid prototyping machine which fabricate a rapid prototype of the patient's dentition as well as a dental implant analog position.

Laser-Produced Porous Surface

Publication No.:  US2024156605A1 16/05/2024
Applicant: 
HOWMEDICA OSTEONICS CORP [US]
THE UNIV OF LIVERPOOL [GB]
Howmedica Osteonics Corp,
The University Of Liverpool
US_2020306048_A1

Absstract of: US2024156605A1

A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.

3D BIOPRINTER WITH CONTINUOUS WORKFLOW CAPABILITY

Publication No.:  US2024157629A1 16/05/2024
Applicant: 
MARTINEZ HECTOR [SE]
THAYER PATRICK [US]
GATENHOLM ERIK [SE]
EICKHOFF HOLGER [DE]
CELLINK BIOPRINTING AB [SE]
Martinez Hector,
Thayer Patrick,
Gatenholm Erik,
Eickhoff Holger,
Cellink Bioprinting AB
WO_2022192768_PA

Absstract of: US2024157629A1

Bioprinters use biological inks (i.e. bioinks) to produce biomaterials such as cell cultures (including 3D cell cultures), living tissues, and organs. Bioprinters as described by the present invention include those capable of performing high-throughput industrial scale assays, applications, and development while maintaining precision.

THREE DIMENSIONAL ROBOTIC BIOPRINTER

Publication No.:  US2024156492A1 16/05/2024
Applicant: 
MAZOR ROBOTICS LTD [IL]
Mazor Robotics Ltd
CN_116602771_PA

Absstract of: US2024156492A1

A minimally invasive system using a surgical robot as a three-dimensional printer for fabrication of biological tissues inside the body of a subject. A preoperative plan is used to direct and control both the motion of the robot and the robotic bio-ink extrusion. The robotic motion is coordinated with the ink extrusion to form layers having the desired thickness and dimensions, and use of different types of ink enables composite elements to be laid down. Such systems have a small diameter bio-ink ejecting mechanism, generally in the form of a piston driven cannula, enabling access to regions such as joints, with limited space. The robotic control is programmed such that angular motion takes place around a pivot point at the point of insertion into the subject. The bio-inks can be stored in predetermined layers in the cannula to enable sequential dispensing from one cannula.

PATIENT SPECIFIC SURGICAL GUIDE LOCATOR AND MOUNT

Publication No.:  US2024156468A1 16/05/2024
Applicant: 
MICROPORT ORTHOPEDICS HOLDINGS INC [NL]
Microport Orthopedics Holdings, Inc
US_2023371960_PA

Absstract of: US2024156468A1

A resection guide locator includes a bone engagement portion with surfaces that are complementary to the surface topographies of a bone to be resected during surgery. A housing includes a socket defined by a resilient annular wall that is sized and arranged so to accept a resection guide by press-fit to thereby position and hold the resection guide within the socket. The resection guide is maintained in a predetermined, preferred position while the surfaces are releasably locked in position on the bone. A method is disclosed for forming and using the resection guide locator.

CERAMIC SCAFFOLD

Publication No.:  US2024157024A1 16/05/2024
Applicant: 
UNIV OF SOUTHERN CALIFORNIA [US]
University of Southern California
CN_114901321_PA

Absstract of: US2024157024A1

This disclosure generally relates to a ceramic scaffold. This disclosure particularly relates to a ceramic scaffold useful for bone regenerations. This disclosure also relates to a ceramic scaffold comprising hydroxyapatite (HA), tricalcium phosphate (TCP), or a mixture thereof. This disclosure also relates to a ceramic scaffold with high mechanical strength and flexibility. This disclosure further relates to a ceramic scaffold manufactured through a three-dimensional (3D) printing process, methods of manufacturing a ceramic scaffold and methods of replacing bone in a subject using the ceramic scaffold.

RESORBABLE DEVICE FOR BONE REGENERATION

Publication No.:  EP4368215A1 15/05/2024
Applicant: 
D & D S R L [IT]
UNIV DEGLI STUDI GENOVA [IT]
D. & D. S.r.l,
Universita' degli Studi di Genova
EP_4368215_PA

Absstract of: EP4368215A1

The present invention relates to a resorbable device for bone regeneration comprising a main body of bioresorbable polymeric material, wherein said main body comprises at least a portion for anchoring said device to a portion of alveolar bone, wherein said main body comprises at least an osteoconductive substance selected from: hydroxyapatite and/or tricalcium phosphate in alpha or beta form, brushite, monetite, or mixtures thereof.The device according to the present invention, has the advantages of being an easy-to-graft bone regeneration device that does not require preoperative device modeling and does not require the removal thereof by means of a second surgical operation.

SPRAYED MULTI ADSORBED-DROPLET REPOSING TECHNOLOGY (SMART)

Publication No.:  EP4366703A2 15/05/2024
Applicant: 
UNIV TEXAS [US]
Board of Regents, The University of Texas System
CN_117940219_PA

Absstract of: CA3226174A1

Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.

INTELLIGENT THREE-DIMENSIONAL BIOMIMETIC STRUCTURE AND USE THEREOF

Publication No.:  EP4368214A1 15/05/2024
Applicant: 
INST POLITECNICO DE LEIRIA [PT]
Instituto Polit\u00E9cnico De Leiria
EP_4368214_PA

Absstract of: EP4368214A1

The invention describes an intelligent three-dimensional biomimetic structure and the use thereof in the regeneration of bone tissue after a trauma or cancer situation.Said intelligent three-dimensional biomimetic structure is comprised of filaments constituted by polymers mineralized with hydroxyapatite, which are able to mimic the bone tissue in terms of composition, morphology, and mechanical properties.

PROCESS FOR THE MANUFACTURE OF A SOLID PHARMACEUTICAL ADMINISTRATION FORM

Publication No.:  EP4366705A1 15/05/2024
Applicant: 
MERCK PATENT GMBH [DE]
Merck Patent GmbH
KR_20240034790_PA

Absstract of: AU2022308624A1

The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising mesoporous silica using a 3D printing process. The process is a printing process that allows the production of solid pharmaceutical administration forms comprising drug loaded mesoporous silica in an easy and flexible manner and in conformity with the high-quality standards required for the production of pharmaceutical

STARCH BASED PRINTABLE MATERIALS

Publication No.:  EP4366706A1 15/05/2024
Applicant: 
ROQUETTE FRERES [FR]
ROQUETTE FRERES
KR_20240035438_PA

Absstract of: WO2023281031A1

The instant invention relates to a printable material for Hot Melt Extrusion- based 3D printing (HME-3DP) comprising a pregelatinized cross-linked starch and hydroxypropyl methyl cellulose (HPMC). It also relates to a process for 3D printing using the same. It also relates to products, in particular controlled release solid dosage forms, obtained thereof by 3D printing.

STARCH BASED PRINTABLE MATERIALS

Publication No.:  EP4366932A1 15/05/2024
Applicant: 
ROQUETTE FRERES [FR]
ROQUETTE FRERES
KR_20240032843_PA

Absstract of: CN117615897A

The present invention relates to a printable material for 3D printing, the printable material comprising a hydrolyzed and functionalized starch compound. The invention further relates to a method for conducting 3D printing through the 3D printer. The invention also relates to products thus obtained by 3D printing, in particular solid dosage forms.

NETWORK ENABLED 3D PRINTING AND AUTOMATED PROCESSING TECHNIQUES FOR ORAL DEVICES

Publication No.:  EP4366939A1 15/05/2024
Applicant: 
RESET TECH CORPORATION [US]
Reset Technology Corporation
US_2023008260_PA

Absstract of: US2023008260A1

Network enabled 3D printing and automated processing techniques for oral devices are disclosed herein. An example technique includes receiving, via a network, a data file representative of a mouth of a user, and printing, by a 3D printer, a 3D oral device based on the data file. The example technique may further include automatically ejecting, from the 3D printer, the 3D oral device, and scanning the 3D oral device to generate a 3D scan file of the 3D oral device. The example technique may further include comparing the 3D scan file with the data file to determine at least one feature represented in the 3D scan file that exceeds a deviation threshold relative to a corresponding respective feature represented in the data file; and finishing, by a finishing module, the 3D oral device by smoothing the at least one feature on the 3D oral device.

一种定制化3D打印颅骨缺损保护支具

Publication No.:  CN220938299U 14/05/2024
Applicant: 
武汉真彩智造科技有限公司
CN_220938299_U

Absstract of: CN220938299U

本实用新型涉及医疗器械技术领域,特别涉及一种定制化3D打印颅骨缺损保护支具。本实用新型的定制化3D打印颅骨缺损保护支具包括3D打印防护板,所述3D打印防护板的两端设有连接点,两个所述连接点之间连接有束缚带。优点:结构设计简单、合理,能够有效的保护颅骨缺损部位,促进患者的恢复。

脂肪族聚酯型聚氨酯丙烯酸酯及其制备方法和应用、3D打印光固化材料及其制备方法和应用

Nº publicación: CN118027350A 14/05/2024

Applicant:

爱迪特(秦皇岛)科技股份有限公司

Absstract of: CN118027350A

本发明提供了一种脂肪族聚酯型聚氨酯丙烯酸酯及其制备方法和应用、3D打印光固化材料及其制备方法和应用,涉及牙科材料技术领域。本发明提供的脂肪族聚酯型聚氨酯丙烯酸酯不含苯环苄基结构,‑NOC与‑OH形成氢键结构,显著提高了脂肪族聚酯型聚氨酯丙烯酸酯的刚性,避免其出现黄变现象;酯基提供优异的韧性和抗变形能力,且无吸水性;氢键和酯基的共同作用形成坚韧性能优异的脂肪族聚酯型聚氨酯丙烯酸酯,抗断裂性和抗变形能力优异;六元环空间占位大,可降低固化后的体积收缩率,抗变形能力优异。本发明提供的脂肪族聚酯型聚氨酯丙烯酸酯能显著降低3D打印光固化材料的吸收性,提高其韧性、抗断裂性和抗变形性。

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