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多层仿生支架及其制备方法

Resumen de: CN120941625A

本发明公开了一种多层仿生支架及其制备方法。所述多层仿生支架的制备方法包括以下步骤：S1、对牺牲材料进行逐层3D打印，连续打印n层，得到网格状多孔内模具；S2、在所述网格状多孔模板内灌注仿生水凝胶前体溶液，然后进行光固化交联，形成牺牲材料‑水凝胶复合体；S3、重复步骤S1和S2，形成多层牺牲材料‑水凝胶复合体；S4、采用溶剂溶解法对所述多层牺牲材料‑水凝胶复合体进行内脱模处理，得到多层仿生支架。该制备方法基于内脱模技术实现分层仿生设计，确保了不同仿生层的水凝胶各自独立存在，避免了一次性灌注时相邻层之间仿生材料的混合和扩散问题，精准实现不同仿生层的设计，同时也确保有效固化。

嵌段共聚体及包括其的聚氨酯丙烯酸酯、树脂组合物、3D打印树脂材料、牙套

Resumen de: CN120944116A

本发明提供一种嵌段共聚体，嵌段共聚体包括ABA嵌段序列，ABA嵌段序列包括A嵌段序和B嵌段，A嵌段为可与聚氨酯形成氢键的聚酯嵌段，B嵌段为聚醚嵌段或聚硅氧烷嵌段中的至少一种，在B嵌段的两端连接A嵌段构成ABA嵌段序列。在应用上述嵌段共聚体和聚氨酯合成的聚合物中，嵌段共聚体促进了聚氨酯形成均匀分布的小硬域，避免材料应力集中，使得聚合物能够兼备良好的力学强度以及良好的抗应力松弛性能。

基于单元设计的可局部微调的脊柱侧弯矫形器及制造方法

Resumen de: CN120938696A

本发明属于矫形设备技术领域，涉及一种个性化脊柱侧弯矫形器设计及制造方法，该设计通过局部刚度的动态调整来适应矫形的不同阶段对矫形器局部刚度的需求改变，解决了传统矫形器单一模式、舒适性差、调节困难、无法适应动态康复需求的难题。该个性化脊柱侧弯矫形器主体由多个基本单元组成，通过一个或多个基本单元的局部形变，实现局部区域刚度的提升和降低进而实现矫形器整体的矫形功能性调整。本发明允许矫正过程中患者骨骼形态随矫正过程的不断改变而进行实时修正矫形策略，无需重新取模和制备新的矫形器，能够实现即时的局部个性化的矫正，相较于传统矫形器，极大的提升了矫形器的穿戴舒适性。

INJECTABLE AND 3D EXTRUSION PRINTABLE HYDROPHILIC SILICONE-BASED HYDROGEL FOR CONTROLLED DRUG RELEASE

Resumen de: US2025345272A1

This invention arrests the hydrophilic silicone macrochains into semi-interpenetrating polymer network via in situ photo-gelation assisted 3D microextrusion printing technique. The printed hybrid hydrogel has shown microporous morphology with tunable diffusion behaviour. The flow behaviour of the hydrogel has been tested showing high elastic modulus, low tan δ, high gel strength, and delayed network rupturing behaviour. The uniaxial compression test showed the almost zero permanent set which could promote it as an elastomer mimetic soft biomaterial. Moreover, the drug loading into the hydrogel has been performed which showed hydrophilic silicone dependent non-Fickian anomalous transport. The encapsulated drug stability inside hydrogel matrices also showed no deterioration of the pristine drug molecules even after one month storage. This could be the first hydrodrophilic silicone based soft biomaterial will serve as an excellent controlled drug delivery device.

METHOD FOR PROVIDING A 3D-PRINT DATA SET OF A DENTAL MODEL STRUCTURE, COMPUTER PROGRAM PRODUCT, DENTAL MODEL STRUCTURE, MOUNTING PLATE AND DENTAL MODEL SYSTEM

Resumen de: US2025345158A1

The invention relates to a method for providing a 3D-print data set of a dental model structure (100) to be mounted on an articulator (5), comprising:providing an articulator data set of the articulator (5) on which the dental model structure (100) is to be mounted;providing a dental situation data set which represents a dental situation of an upper jaw and/or a lower jaw, the dental situation data set including data to display the dental situation as a virtual representation of the dental situation on a display;selecting at least one distance element (20) from a plurality of different predefined and/or prefabricated distance elements based on the articulator data set and the dental situation data set;generating a connecting structure data set representing at least a virtual connecting structure (15) arranged between the virtual representation of the dental situation and a virtual representation of the at least one selected distance element; andgenerating the 3D-print data set based on the dental situation data set and the connecting structure data set.Furthermore, the invention relates to a corresponding computer program product, a dental model structure, a mounting plate and a dental model system.

Piezoelectric Stents with Self-Powered Anti-Restenosis Properties

Resumen de: US2025345193A1

An electric field-assisted 3D printing system that allows for fast printing of complex and spontaneously polarized ferroelectric structures with high fidelity and superb piezoelectric performance. The system provides the basis for development of a piezoelectric vascular structure that can serve as a stent, providing self-powered electricity to prevent restenosis and biologic growth by producing a low intensity electric field around the stent.

Bioink Compositions and Methods for 3D Printing Of Vascularized Tissue Constructs

Resumen de: US2025345480A1

Compositions and methods for bioprinting a transplantable vascularized tissue construct that allows for direct surgical anastomosis to a host, to achieve immediate blood perfusion with host vasculature for long-term cell survival and function.

3D PRINTED GALLIUM SCAFFOLD

Resumen de: US2025345482A1

A biocompatible 3D-printed scaffold is described. The scaffold includes a biocompatible polymer shaped to form a scaffold using 3D printing and a gallium compound. Methods of making 3D-printed scaffolds, and methods of using 3D-printed scaffolds to inhibit bone resorption are also described.

PREPARATION GUIDE FOR A DENTAL PREPARATION

Resumen de: US2025345154A1

The invention relates to a method for generating a three-dimensional digital guide model of a physical preparation guide for a dental preparation of a patient's jaw. A three-dimensional digital jaw model and a definition of tooth positions is received. The tooth positions comprise one or more target tooth positions for one or more artificial teeth. The three-dimensional digital jaw model is overlaid with a three-dimensional digital corrugated surface. The overlaying comprises adjusting a waveform of the corrugation with local minima and maxima, such that the local minima are arranged at the positions of the teeth, while the local maxima are arranged between the positions of the teeth. The three-dimensional digital guide model is generated using the three-dimensional digital corrugated surface with the adjusted waveform.

METHOD FOR PROVIDING DENTAL ALIGNERS TO A SUBJECT SHOWING A NON-ALIGNEMENT OF ITS DENTITION

Resumen de: US2025345151A1

A personalized method for providing at least one dental aligner; the method being with reference to an actual state of the dentition of the patient and in view of an improvement plan of the alignment targeted over a period of time ranging from 1 to 16 weeks, of the teeth of a subject. The method includes the steps of: (i) providing a 2D image and/or 3D volume of the dentition of a subject showing a non-alignment of its dentition; (ii) recovering clinical markers of the subject; (iii) producing an initial set of manufacturing parameters of the at least one aligner; (iv) building up an image of the 1-16 weeks target of improvement; and (v) directly 3D printing of the at least one personalized aligner fitting with the predicted evolution of intermediate tooth displacement for each tooth of the patient during the improvement plan.

ADDITIVES FOR 3D PRINTING POLYMER RESINS

Resumen de: US2025346703A1

The present disclosure provides micelles comprising a plurality of block co-polymers, the micelle comprising (i) a core comprising at least a portion of a poly(alkyl acrylate) block of one or more of the block co-polymers; and (ii) an outer layer comprising at least a portion of a poly(aryl acrylate) block or a poly(aryl methacrylate) block of one or more of the block co-polymers. The present disclosure also includes polymer compositions, polymer films, and devices (e.g., orthodontic equipment) including the same. Methods for making and using micelles, polymer compositions, polymer films, and devices (e.g., orthodontic equipment) are also disclosed. Further provided herein are methods of producing polymer compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

3D PRINTING COMPOSITIONS FOR STAIN RESISTANT AND MORE TRANSPARENT DENTAL MATERIALS FROM POLYOLEFIN DERIVED POLYOLS

Resumen de: US2025346708A1

The present disclosure provides novel oligomer compounds (e.g., non-polar oligomers) that can produce desirable polymeric materials (e.g., with polar reactive diluents), polymer compositions, and/or photo-curable resins that have excellent stain resistance. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances with increased stain resistance.

Drucktinte zur Herstellung von Gewebe und Verfahren zu deren Herstellung sowie Verfahren zur Herstellung von Gewebe und mit dem Verfahren herstellbares Gewebe

Resumen de: DE102024204366A1

Die vorliegende Erfindung betrifft eine Drucktinte zur Herstellung von Gewebe, vorzugsweise physiologischem Gewebe. Die Drucktinte umfasst mindestens einen Polyelektrolytkomplex und Wasser, wobei der mindestens eine Polyelektrolytkomplex mindestens ein Strukturprotein sowie mindestens ein anionisches Polysaccharid und/oder Polysaccharid-Derivat enthält oder daraus besteht, und wobei das mindestens eine anionische Polysaccharid und/oder Polysaccharid-Derivat in einer Konzentration von mindestens 0,1 mg/ml in der Drucktinte enthalten ist. Zudem betrifft die vorliegende Erfindung auch ein Verfahren zur Herstellung der erfindungsgemäßen Drucktinte, ein Verfahren zur Herstellung von Gewebe, in welchem die erfindungsgemäße oder erfindungsgemäß hergestellte Drucktinte verwendet wird, sowie ein mit dem Verfahren herstellbares oder hergestelltes Gewebe.

Verfahren zum Fertigen eines Hüftimplantats, individualisiertes Hüftimplantat

Resumen de: DE102024112836A1

Die Erfindung betrifft ein Verfahren zum Fertigen eines Hüftimplantats (20), wobei das Verfahren umfasst: Bereitstellen eines Patienteninformationsdatensatzes (72), der Informationen zu einer Form eines Hüftbeins (10) mit einem Hüftpfannendefekt (11) umfasst, Erzeugen eines Formdatensatzes (76), der Informationen zu einer Sollform für ein Hüftimplantat für den Hüftpfannendefekt umfasst, wobei die Sollform eine Individualkomponente (32,38,44,54) aufweist, deren Abmessung und/oder Anordnung durch wenigstens einen veränderbaren Geometrieparameter charakterisiert sind, und wobei das Erzeugen des Formdatensatzes das Festlegen des wenigstens einen Geometrieparameters in Abhängigkeit von dem Patienteninformationsdatensatz umfasst, und Fertigen eines individualisierten Hüftimplantats in Abhängigkeit von dem Formdatensatz. Die Erfindung betrifft außerdem ein individualisiertes Hüftimplantat.

IMPLANT

Resumen de: AU2024241734A1

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

A METHOD FOR PRODUCING AND USING A COMPLEX FLUID

Resumen de: AU2024311509A1

Disclosed is a method for producing complex fluid of bubbly liquid material that is suitable for being used in 3D printing, the method comprising producing to liquid material primary bubbles (420), and optionally secondary (425) and tertiary bubbles, as a supporting material for printing a 3D object (415) or for using as printing ink, wherein the liquid material comprises at least the primary bubbles.

Integrally formed medical devices

Resumen de: AU2025100016A4

INTEGRALLY FORMED MEDICAL DEVICES Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific interbody spinal fusion medical device (1100), wherein the medical device (1100) is integrally formed using an additive manufacturing process, the medical device (1100) including: a body portion (1150) having at least one surface (1115) that is contoured to fit an anatomy of the patient; a graft window (1160) defining an aperture through said body portion (1150), such that said body portion (1150) defines a cage; and an identifier (1190) integrally formed on the device (1100). Se p 25 INTEGRALLY FORMED MEDICAL DEVICES 2025100016 19 2025 Sep Abstract Disclosed herein are integrally formed medical devices and methods relating thereto. One embodiment provides an integrally formed patient-specific interbody spinal fusion medical device (1100), wherein the medical device (1100) is integrally formed using an additive manufacturing process, the medical device (1100) including: a body portion (1150) having at least one surface (1115) that is contoured to fit an anatomy of the patient; a graft window (1160) defining an aperture through said body portion (1150), such that said body portion (1150) defines a cage; and an identifier (1190) integrally formed on the device (1100). INTEGRALLY FORMED MEDICAL DEVICES Abstract - 21/30 - Fig. 12 Se p

PIEZOELECTRIC COATED IMPLANTS AND METHODS OF USING PIEZOELECTRIC COATED IMPLANTS TO REPAIR BONE STRUCTURES

Resumen de: AU2025259808A1

TITLE: PIEZOELECTRIC COATED IMPLANTS AND METHODS OF USING 5 PIEZOELECTRIC COATED IMPLANTS TO REPAIR BONE STRUCTURES Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are coated with, or have struts formed from, a piezoelectric material to 15 enhance bone growth around and through the implant. 5 TITLE: PIEZOELECTRIC COATED IMPLANTS AND METHODS OF USING PIEZOELECTRIC COATED IMPLANTS TO REPAIR BONE STRUCTURES Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts 15 joined at nodes. Implants are coated with, or have struts formed from, a piezoelectric material to enhance bone growth around and through the implant. ct : c t

System, Method, and Apparatus for Remote Patient Care

Resumen de: US2025346051A1

A portable patient-care kit is disclosed. The kit includes a housing, a plurality of compartments and a touch-screen user interface device. The housing forms a container space. The plurality of compartments is disposed within the container space such that each compartment is configured to retain at least one medical apparatus. The touch-screen user interface device has a transceiver that can communicate via a mobile data network.

THERAPEUTIC ULTRASONICATION SYSTEM FOR OPENING BLOOD-BRAIN BARRIER AND ULTRASONIC WAVE CONTROL METHOD OF THERAPEUTIC ULTRASONICATION SYSTEM FOR OPENING BLOOD-BRAIN BARRIER

Resumen de: EP4647119A1

The present invention relates to an ultrasonic wave control method of a therapeutic sonication system for opening a blood-brain barrier, the method comprising the steps of: setting output conditions for outputting ultrasonic energy to an acoustic cavitation-inducing substance administered to a subject; outputting ultrasonic energy corresponding to the output conditions to the subject; receiving an acoustic signal resulting from acoustic cavitation induced by the acoustic cavitation-inducing substance; analyzing the acoustic signal to determine whether preset control conditions have been satisfied; and, depending on whether the preset control conditions have been satisfied, outputting ultrasonic energy after adjusting at least one of a duty cycle, the number of stimulation pulses per a predetermined time unit, pulse repetition frequency per a predetermined time unit, and applied voltage, among the output conditions of ultrasonic energy, or stopping the outputting of ultrasonic energy.

一种植物纤维改性3D打印材料及其制备方法

Resumen de: CN120923991A

本申请涉及3D打印材料技术领域，更具体地说，涉及一种植物纤维改性3D打印材料及其制备方法，由以下重量份的原料制备得到：聚乳酸、植物纤维粉末、聚琥珀酸丁二醇酯、多孔球形碳酸钙、乙烯‑丙烯酸共聚物、海藻酸钠、醋酸纤维素、植物型纳米晶、交联剂、润滑剂、所述植物型纳米晶由纤维素纳米晶、硅纳米晶和羟基磷灰石纳米晶组成，通过采用上述配方使材料在喷嘴中更顺畅地流动，从而有效避免熔融或光固化喷嘴在打印细小线径时出现的极易堵塞、空打或缠线等问题，降低批次报废率，提高生产效率。同时在后拉伸细化过程中，即使在较大范围内调整拉伸参数，也不易出现过拉易断、欠拉强度不足的情况，从而保证了3D打印手术缝线的质量和性能。

一种基于3D打印的可降解引流支架

Resumen de: CN120918853A

本发明涉及引流支架技术领域，公开了一种基于3D打印的可降解引流支架，包括引流管以及操作台，引流管包括第一管体和第二管体，第一管体和第二管体的侧壁上均开设有多个圆孔，第一管体和第二管体间设有连接组件；第一管体的端部处设有限位件；操作台的上端面设有升降板，升降板的上端面安装有操作杆，操作杆的下端面安装有操作板，操作板的上端面安装有第一卡杆，第一卡杆的下端面安装有第一卡块，操作台的上端面设有升降组件。通过上述构造，使得第一管体、第二管体、波纹管以及螺纹部均通过3D打印机制成，其材料通过可降解的材质制成，使得引流支架本体能够自然溶解在患者体内，避免患者需要进行二次手术的情况。

一种酸性含端肽胶原的提取方法及其应用

Resumen de: CN120923612A

本申请公开了一种酸性含端肽胶原的提取方法及其应用，涉及生物材料技术领域，包括将牛组织剔除脂肪，分割成均匀的物质，依次使用碱性溶液、碳酸盐溶液、有机溶剂溶液及盐溶液浸泡后沥干，酸性溶液浸泡提取、离心除杂、酸碱中和、离心、二次酸溶、超滤、微孔过滤、制剂等手段制备出含端肽胶原；能够制备出纯度高，端肽保留率高的含端肽胶原；含端肽胶原的端肽胶原在交联位点上，端肽区域含有特定的氨基酸，是胶原分子之间和胶原纤维内部形成共价交联的关键位点，力学强度高，适用于软骨组织修复等领域。

一种3D打印仿骨生物支架及其制备方法

Resumen de: CN120919420A

本发明涉及骨修复领域，公开了一种3D打印仿骨生物支架及其制备方法，首先将溴化铵加入去离子水和无水乙醇的混合物中，得到溴化铵溶液；依次加入氨溶液、正硅酸乙酯、磷酸三乙酯、硝酸钙和钒酸钠，并持续搅拌后离心，收集沉淀物；洗涤、陈化后，加热后降温，研磨粉碎后筛分，得到V‑MBG粉末；配置TA溶液和V‑MBG溶液，混合后放入，冷冻干燥得到TA@V‑MBG粉末；制备PLGA的三氯甲烷溶液，加入V‑MBG粉末充分搅拌后，抽干三氯甲烷溶液，得到固体浆料；打印出内层支架和空心管外层支架，得到仿骨生物支架，浸泡在TA溶液中，得到PLGA/TA@V‑MBG复合支架；本发明解决了现有技术中骨修复效果不好、骨样细胞增殖与分化效果不好，无法实现治疗骨肿瘤导致的骨缺损修复的问题。

一种3D打印内侧髌股韧带重建股骨隧道定位器及其制备装置

Nº publicación: CN223529474U 11/11/2025

Solicitante:

昆明医科大学第一附属医院

Resumen de: CN223529474U

本申请属于医疗器械技术领域，公开一种3D打印内侧髌股韧带重建股骨隧道定位器及其制备装置，其中，3D打印内侧髌股韧带重建股骨隧道定位器包括第一圆柱体、第二圆柱体、适骨壳和操作杆；其中，第二圆柱体的直径大于第一圆柱体的直径，第二圆柱体的长度小于第一圆柱体的长度，第二圆柱体套接于第一圆柱体的外侧，适骨壳套接于第二圆柱体的外侧，操作杆与第二圆柱体的外侧固定连接。本申请通过第一圆柱体可以穿过标准手术切口，第二圆柱体套接于第一圆柱体，以安装操作杆和适骨壳，其中操作杆方便对定位器的操作，通过适骨壳可牢固地贴合到股骨后髁沟，从而实现与股骨的完美贴合，保证定位的准确性。