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一种种植模型3D打印树脂材料及其应用

Resumen de: CN121570635A

本发明公开了一种种植模型3D打印树脂材料，包含如下按重量份计的原料组分：聚氨酯丙烯酸酯低聚物30‑50份；单官能团活性稀释剂30‑40份；双官能团活性稀释剂20‑40份；光引发剂1‑3份；流平剂0.1‑3份；消泡剂0.1‑3份；填料0.5‑3份；耐刮蜡0.5‑3份；颜料0.2‑0.5份；聚氨酯丙烯酸酯低聚物与活性稀释剂的质量比为（0‑1）：1；所述单官能团活性稀释剂和双官能团活性稀释剂的质量比为（1‑1.5）：1。该树脂材料通过引入聚氨酯丙烯酸酯体系，改善后的光敏树脂通过3D打印制造的种植牙模，具有高下机精度、高逆扫尺寸稳定性、高性价比，应用于口腔医学领域。

一种蜂窝状刚性-柔性两相颗粒及其在光固化3d打印树脂中的应用

Resumen de: CN121574311A

本发明公开了一种蜂窝状刚性‑柔性两相颗粒及其在光固化3d打印树脂中的应用。该蜂窝状刚性‑柔性两相颗粒包括柔性聚氨酯相和刚性氧化硅相。制备步骤S1、制备包含聚氨酯颗粒的乳液作为种子乳液（乳液A）；S2、制备包含氧化硅前体和引发剂的乳液（乳液B）；S3、将乳液B加入到乳液A中，混合均匀得到混合液；S4、在施加动态作用和无氧条件下，将混合液升温至60‑80℃反应20～24h，得到含有蜂窝状刚性‑柔性两相颗粒的乳液。将含有蜂窝状刚性‑柔性两相颗粒的乳液加入到具有光固化性能的可降解聚合物材料中能同时提升聚合物材料的韧性和强度，且不影响聚合物的光固化性能和生物相容性；适用于作为填料添加到高精度光固化3d打印制备的各类成型制品。

数字化可无线传输的3D打印支具多参数监测系统及方法

Resumen de: CN121572596A

本申请涉及医疗器械与智能健康监测技术领域，公开了一种数字化可无线传输的3D打印支具多参数监测系统及方法，旨在解决刚性支具与柔性传感器因弹性模量差异大而导致的界面应力集中、传感器易脱落及信号精度差的问题。该系统通过3D打印在支具内表面构建梯度互锁界面结构，并原位成型柔性多参数传感阵列，实现刚柔一体化；还包括嵌入式数据采集处理单元、无线传输模块及微型能源模块。该方法包括三维建模分区、梯度界面路径生成、多材料协同打印、信号同步采集融合及无线传输。本发明显著提升界面结合强度与监测精度，简化制造流程，支持个性化定制。

辅助器打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

The invention discloses an artificial limb printing method and device, electronic equipment, a storage medium and a computer program product.The method comprises the steps that a first physiological data set of a first user is obtained; calling a first artificial intelligence model to process the first physiological data set to obtain a first constraint parameter set; the first artificial intelligence model is used for recommending a constraint parameter group based on an input physiological data group; the constraint parameter set represents constraints related to the mechanical performance requirements corresponding to the input physiological data set; taking the first constraint parameter group as a constraint, and calling a generative design algorithm to process the first physiological data group to obtain a first design parameter group; the generative design algorithm is used for generating a design parameter group meeting the corresponding comfort requirement on the basis of the input physiological data group, and the design parameter group comprises a plurality of design parameters of the artificial limb; and generating a first file based on the first design parameter group and the slice parameter group, and outputting the first file to the three-dimensional printing device.

一种颈椎单开门手术3D打印导板的制作方法

Resumen de: CN121572598A

本发明公开了一种颈椎单开门手术3D打印导板的制作方法，涉涉及医疗辅助器械与增材制造交叉技术领域，先获颈椎CT数据三维重建骨骼模型，虚拟规划手术方案，再参数化生成导航模板数字化原型，经有限元仿真优化，用光固化设备以生物相容性树脂打印，最后处理得终产品。本发明通过CT薄层扫描与三维重建生成高精度颈椎骨骼模型，经虚拟规划确定铰链区、开门槽线及钉道参数，解决传统手术依赖经验易致损伤或定位偏差问题；再以特定算法构导航模板贴附曲面并留软组织补偿间隙，配镂空窗凸起限磨钻深度，同时经有限元仿真与拓扑优化控导板变形，选特定树脂保稳定性，借虚拟配准与标准化制造保适配性，提升手术精准安全与效率。

一种负泊松比结构多功能血管支架及其制备方法

Resumen de: CN121571655A

本发明公开了一种负泊松比结构多功能血管支架及其制备方法，涉及医疗器械技术领域，包括负泊松比结构的血管支架模型的构建、选区激光熔化增材制造、化学抛光处理以及表面仿生改性处理。该支架利用负泊松比特性能够更好地适应血管的变形，减少因变形不同步产生的不相容性，其结构圆润平滑，可有效避免传统支架锐利拐角处易产生的血流湍流与涡流，改善血流动力学性能，降低血小板激活与血栓形成的风险，通过制备表面梯度涂层，实现多机制协同，有利于支架表面内皮层的形成。

一种具有生物相容性的低粘度树脂组合物及其制备方法和应用

Resumen de: CN121574312A

本发明提供了一种具有生物相容性的低粘度树脂组合物及其制备方法和应用，涉及临时牙冠树脂材料的技术领域。所述具有生物相容性的低粘度树脂组合物按重量份数计包括：丙烯酸酯树脂10~40份、活性稀释剂30~60份、改性填料10~50份、光引发剂0.5~2.5份、助剂0.5~5份；所述改性填料为钛酸酯偶联剂改性纳米填料，且所述钛酸酯偶联剂改性纳米填料包括纳米填料内核、以及包覆于所述纳米填料内核的表面的单分子钛酸酯偶联剂包覆层。本发明提供的临时牙冠用树脂组合物的粘度较低，流动性优异，利于材料打印成型；同时，保证了所制备的材料具有较好的生物相容性以及力学强度。

一种基于3D打印的双层载药植入体及其制备方法与应用

Resumen de: CN121570412A

本发明属于药物共递送技术领域，具体涉及一种基于3D打印的双层载药植入体及其制备方法与应用。本发明通过合成明胶甲基丙烯酸酯GelMA；制备2‑氨基葡萄糖修饰的奥沙利铂Oxa‑2‑DG；MExo的提取与纯化；GelMA的3D打印与AI优化最终制备获得具有双层结构的载药植入体LEH@OG。本发明制备的共递送平台可在腹腔内降解，实现内外层药物的序贯释放，具有较高的生物安全性，对各组织脏器均无明显损伤。并表现出强大的抗肿瘤疗效和免疫激活作用。

一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法

Resumen de: CN121572585A

本发明公开了一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法。该方法构建了一个数字化闭环流程：首先通过口内扫描与数字化排牙设定矫治目标；继而利用收缩包裹算法构建矫治器光滑包络空间；采用基于PointNet++的AI技术精准分割牙冠以界定力边界；通过厚度控制与边缘优化算法生成形态精确、力学稳定的矫治器数字模型；最后，基于DLP技术使用生物相容性树脂直接打印矫治器，并经过严格的二次固化等后处理确保其性能与安全。本发明省去了传统压膜工艺，从根本上消除了累积误差，并能通过工艺控制实现矫治器力学性能的个性化梯度设计，标志着隐形矫治技术从“形态匹配”迈向“功能适配”。

3D BIOPRINTED LIVER

Resumen de: WO2026043615A1

The present disclosure provides 3D bio-printed livers and methods of making or using the same. Aspects of the disclosure relate to compositons of 3D bio-printed livers. In some embodiments, the 3D bio-printed livers comprise a mesh casing, a plurlaity of microporous organoid-infused microgel matrices, and a hetaptic vasculature. Other aspects of the disclosure relate to methods of making the 3D bio-printed livers dislcosed herein. In some embodiments, the methods relate to creating a mesh casing in the shape of a liver, or portion thereof, loading a plurality of microporous organoid-infused microgel matrices into the mesh casing, and using embedded bioprinting to create a hepatic artery, a portal vein, and biliary duct within the mesh casing.

POROUS INTERBODIES

Resumen de: WO2026043576A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

CURABLE COMPOSITION FOR THREE-DIMENSIONAL STEREOLITHOGRAPHY, METHOD FOR PRODUCING OBJECT BY THREE-DIMENSIONAL STEREOLITHOGRAPHY, AND METHOD FOR PRODUCING DENTAL RESTORATION

Resumen de: WO2026042469A1

Provided is a curable composition for three-dimensional stereolithography, the curable composition containing 100 parts by mass of a radical polymerizable monomer (A), 5.0-400 parts by mass of an inorganic filler (B), 0.05-10.0 parts by mass of a photopolymerization initiator (C) containing an acylphosphine compound, 0.01-5.0 parts by mass of a polymerization inhibitor (D), and 0.01-10.0 parts by mass of a photosensitizer (E) including a thioxanthone compound represented by formula (1). The present invention also provides a method for producing an object by three-dimensional stereolithography and a method for producing a dental restoration, the methods using said curable composition for three-dimensional stereolithography. In the formula, Y1 to Y8 each independently represent a hydrogen atom, an alkyl group having 1-20 carbon atoms, or the like.

MICRONEEDLE PARTICLES FOR ENHANCED TOPICAL TRANSDERMAL DRUG DELIVERY

Resumen de: US20260053731A1

A microneedle particle arranged to be rolled and massaged on a subject's skin to penetrate the stratum corneum is disclosed. The microparticle comprises a support body, and a plurality of microneedles protruding from the support body (20), each microneedle comprising a tip. The support body maintains the microneedles and tips in a predetermined conformation allowing the microneedle particle to be rolled on the skin. The microneedles have an average tip sharpness radius of less than 20 μm, an average microneedle length of less than 100 μm, and an average tip sharpness to microneedle length ratio of 1:5 to 1:200. Formulations and kits for said use are provided. A microneedle particle manufacturing method using a non-linear two-photon absorption process, a non-therapeutic cosmetic method of skin treatment, and a method of drug delivery through the skin for said microneedle particle are disclosed.

MANUFACTURE OF PATIENT-SPECIFIC ORTHODONTIC BRACKETS WITH TOOTH-SPECIFIC BREAKAWAY MECHANISM

Resumen de: US20260053596A1

Embodiments may provide improved techniques for creating custom lingual or labial ceramic orthodontic brackets, and which provides the capability for in-office fabrication of such brackets. For example, a method of manufacturing customized ceramic labial/lingual orthodontic brackets by ceramic slurry-based AM may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing data related to the 3D CAD bracket structure model into a ceramic slurry-based AM machine, directly producing the bracket (green part) in the ceramic slurry-based AM machine by layer manufacturing, and processing the brackets in a sintering and debinding oven prior to direct use.

POROUS INTERBODIES

Resumen de: US20260053633A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

SYSTEM, METHOD AND APPARATUS FOR PERSONALIZED DENTAL PROSTHESES PLANNING

Resumen de: US20260053603A1

Methods, systems, and techniques for collecting data for use in designing a personalized dental prosthesis for a patient. At least one camera is used to obtain a series of two-dimensional photos or a three-dimensional model of a head and face of the patient. At least one machine learning model is used to determine facial or oral landmarks and a central incisal edge of the prosthesis from the photos or model. Dimensions for the dental prosthesis are determined form the landmarks and central incisal edge. The dimensions include a labial border of the prosthesis, distal borders of the prosthesis, a superior border of the prosthesis, an inferior border of the prosthesis, a lingual border of the prosthesis, and buccal borders of the prosthesis. The dimensions are output to an output file for use in manufacturing the prosthesis.

SOCKET FORMING TOOLS FOR AUTOTRANSPLANTATION

Resumen de: US20260053600A1

A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.

METHOD OF ASSEMBLING A BIOREACTOR HAVING A BIOLOGICAL MATERIAL DEPOSITING END THAT IS MOVABLE WITH THE TOP PORTION TO ALLOW BIOPRINTING

Resumen de: US20260055354A1

A bioreactor allowing bioprinting inside an interior volume thereof is assembled to form a side wall extending upwardly from a base provided with a target support for the bioprinting. Once an adapter has been coupled to a bioreactor top portion to plug a corresponding aperture O4, a biological material depositing end may be maintained in an inserted state, extending through and/or being adapted to be fed via the aperture. A sealed enclosure, including the side wall and ports, is formed by a sealing operation to interconnect the base and the top portion. Bioprinting is done by driving from outside the depositing end, using variation of said volume, for delivering the biological material on the support and then, a culture and/or maturation phase of the printed tissue may start inside the enclosure, without displacement of the printed tissue.

ADDITIVE MANUFACTURING OF EMBEDDED MATERIALS

Resumen de: US20260053988A1

In one aspect, a method includes providing support material within which the structure is fabricated, depositing, into the support material, structure material to form the fabricated structure, and removing the support material to release the fabricated structure from the support material. The provided support material is stationary at an applied stress level below a threshold stress level and flows at an applied stress level at or above the threshold stress level during fabrication of the structure. The provided support material is configured to mechanically support at least a portion of the structure and to prevent deformation of the structure during the fabrication of the structure. The deposited structure material is suspended in the support material at a location where the structure material is deposited. The structure material comprises a fluid that transitions to a solid or semi-solid state after deposition of the structure material.

ADDITIVE MANUFACTURING PART SUPPORT AND HANDLING FRAME

Resumen de: AU2025210859A1

A cutting instrument includes an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument includes depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly. A cutting instrument includes an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument includes depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, th

RECOMBINANT PROTEINS, RECOMBINANT DNA SEQUENCES, VECTORS, EUKARYOTIC AND PROKARYOTIC EXPRESSION SYSTEMS AND THEIR USE

Resumen de: AU2024288436A1

The invention relates to recombinant RE15mR and EJ17zipR hybrid proteins with the structure specified in the description, recombinant DNA sequences encoding recombinant hybrid proteins, vectors containing recombinant DNA sequences, as well as eukaryotic or prokaryotic expression systems transformed with recombinant DNA sequences. The invention also concerns the use of recombinant hybrid proteins as components of bioink intended for bioprinting, and also as components of biomaterials. Furthermore, the invention relates to the use of recombinant DNA sequences, vectors and eukaryotic or prokaryotic expression systems for the production of recombinant hybrid proteins.

ENZYME AND NANOZYME LOADED MICROPARTICLES

Resumen de: AU2023463148A1

This invention describes microcapsule compositions and methods to encapsulate gas modulating enzymes or nanozymes at unprecedented concentrations and stability, that can be used to regulate the local gas concentrations. Microcapsules can be comprised of gelatin with a polydopamine coating. This system can replace expensive incubators/chambers and is the first system that can create spatiotemporal gradients of gases within a finite volume. The microcapsules have a broad range of applications in tissue culture, bioprinting, in vivo, and industrial uses.

DENTAL DEVICE WITH INTEGRATED FLUIDIC RESERVOIR AND MICROCHANNELS, AND METHOD FOR MANUFACTURING SAID DENTAL DEVICE

Resumen de: WO2026041252A1

The present invention is related to a dental device (1) intended to cover at least part of a teeth (2) and/or at least part of gums (3) or other surfaces of a mouth for repositioning or retaining said teeth (2) and optionally said gums (3) or other surfaces of the mouth, said dental device (1) comprising a channel (7) provided in a main body (31; 40, 42) of the dental device (1) and having at least one opening (4, 5) to the exterior. The present invention is also related to a method of manufacturing said dental device (1) by additive manufacturing and to methods for circulating a substance and/or saliva and oxygen through the dental device (1) in view of releasing said substance and/or saliva and oxygen inside the mouth.

METHOD OF TREATING A WOUND AND METHOD OF MANUFACTURING A SKIN GRAFT

Resumen de: WO2026043980A1

Synthetic skin constructs are produced using 3D bioprinting and a cleaning process involving supercritical carbon dioxide (ScCO2). The ScCO2 process effectively removes all cellular materials, minimizing the risk of immune rejection and ensuring the skin constructs are safe and optimally effective.

DEVICE AND METHOD FOR FOOTWEAR CUSTOMIZATION

Nº publicación: EP4698003A1 25/02/2026

Solicitante:

SUPERFEET AGGREGATOR LLC [US]
Superfeet Aggregator LLC

Resumen de: US20260020643A1

A device and method for the formation of customized footwear insoles and pads is provided. The system employs computers operatively engaged to scanning components to produce individual electronic footprints of a foot of a wearer. Software operating to the tasks of employing the digital data from one or a plurality of electronic footprints, correlating to scans of the feet of a footwear user, will customize an insole or pad for positioning in the footwear to more comfortably support the foot therein.