Alerta

ASSISTED POSITIONING OF A REPOSITIONABLE STRUCTURE

Resumen de: US20260306202A1

A system includes a base, a proximal repositionable structure supported by the base and a distal repositionable structure having a proximal portion supported by the proximal repositionable structure and a distal portion. An actuator system is configured to move the base, the proximal repositionable structure, and the distal repositionable structure. A control system is coupled to the actuator system and is configured to facilitate external repositioning of the distal portion that moves a control feature relative to the base frame, detect first repositioning and based on a first geometric parameter characterizing the control feature after the first repositioning, determine a first base movement of the base and a first structure movement of the proximal repositionable structure, wherein performing the first base movement and the first structure movement together moves a reference feature relative to the control feature, the reference feature fixed relative to a portion of the proximal repositionable structure.

MODULAR ANALYTE CONNECTIVITY SYSTEM FOR EXTENDIBLE COMMUNICATION WITH DIFFERENT TYPES OF PHYSIOLOGICAL SENSORS

Resumen de: US20260310768A1

0000 A medical device communication system with a modular design to communicate with different types of medical devices, such as physiological sensors. The modular design is implemented using an extensible software library that provides a uniform framework for various applications or third party applications access to medical device data. The modular design also allows for regulated and unregulated portions of the system to be integrated into the system while allowing each portion to be updated separately. The regulated portion of the system may include components, such as sensors and the software library, that are subject to regulatory approval while the unregulated portion may include applications that are not subject to regulatory approval. Thus, the system enables a third party application developer to avoid having to submit the application to a regulatory agency for an application making use of the sensor data.

METHOD FOR MONITORING THE SPATIAL DEVIATION WITH RESPECT TO A PLANNED SURGICAL PROCEDURE

Resumen de: US20260306177A1

The present invention relates to a system comprising a processor, the system characterised by the processor having access to a planned surgical procedure comprising one or more three-dimensional (3D) images corresponding to one or more predefined states of the planned surgical procedure in a body portion, the processor is configured to execute instructions to perform the following steps of a method for monitoring the spatial deviation with respect to a planned surgical procedure: a) receiving one or more image of the body portion obtained by an intraoperative imaging device wherein the one or more image is associated to a certain predefined state of the planned surgical procedure; b) superimposing the one or more received images of step a) with the corresponding section of the one or more 3D image of the planned surgical procedure associated to the same predefined state; and c) determining the spatial deviation of the surgical procedure results with respect to the planned surgical procedure from the superimposition of the images of step b). The present invention also refers to a computer program and a method thereof.

Systems and Methods For Determining Neurological Condition Based On Surface Biopotentials

Resumen de: US20260306028A1

0000 Systems and methods for gesture control using biopotential sensing wearable devices are described. The system may include a processing pipeline configured to receive and process user biopotential data. The processing pipeline may be configured to generate, based at least in part on the processed user biopotential data, an assessment of the neurological condition of the user. The processing pipeline may include a machine learning model that has been trained and/or calibrated by one or more of the following: obtaining subject biopotential data collected from a plurality of subjects; obtaining subject neurological health data from the plurality of subjects (the subject neurological health data may relate to the neurological condition; labeling the subject biopotential data using the subject neurological health data to generate labeled subject data; and/or training the machine learning model using the labeled subject data.

COMPUTATIONAL METHODS FOR SELECTING PERSONALIZED NEOANTIGEN VACCINES

Resumen de: US20260311803A1

Systems and methods for identifying a personalized tumor vaccine are provided. Somatic variants for a subject are determined and RNA sequence reads from a tumor of the subject are obtained. From the RNA sequence reads, fusion proteins are determined, each fusion protein a fusion of a portion of a first protein and a portion of a second protein. Candidate neoantigens are selected, including a first subset of candidate neoantigens encoding somatic variants and a second subset of candidate neoantigens encoding residues of the portions of the first and second proteins. A score is determined for each candidate neoantigen using a scoring function including a first scoring term that upweights candidate neoantigens having a higher relative class I MHC affinity, given a class I HLA type of the subject. Two or more candidate neoantigens are selected for the tumor vaccine as a final set of neoantigens based on the respective scores.

METHODS FOR OPTIMIZING TREATMENT TIME AND PLAN QUALITY FOR RADIOTHERAPY

Resumen de: US20260306875A1

Described herein is a graphical user interface that receives a user-specified treatment time value and displays the resultant dose distributions to a target region and/or organs-at-risk (OARs). The dose distributions are depicted as dose volume histograms (DVHs). The user-specified treatment time value may be adjusted as desired and the DVHs for the target region and/or OARs may be correspondingly updated. In some variations, the graphical user interface may comprise bounded DVHs for the target region and/or OARs, where bounds of the DVH represent the range of dose variability between a short treatment time (e.g., Tmin) and a long treatment time (e.g., Tmax). In some variations, the graphical user interface includes a command button that triggers fluence map optimization using the user-specified treatment time.

HYBRID THREE-DIMENSIONAL PRINTING AND ELECTROSPINNING PLATFORM FOR MULTI-LAYERED BIOMIMETIC SCAFFOLDS

Resumen de: US20260306705A1

Example embodiments disclose a hybrid three-dimensional (3D) printing and electrospinning system that includes a 3D printer configured to print biomaterial, the 3D printer includes a printer head assembly for extruding a liquid solution that forms the biomaterial via a nozzle, an electrospinning unit for generating electrospin fibers, wherein the printed biomaterials and electrospin fibers are extruded from the same nozzle, and a collection plate for assembling the printed biomaterial and electrospun fibers.

SYSTEMS AND METHODS FOR CUSTOM 3D PRINTING OF PROSTHETIC EYES WITH ENHANCED FUNCTIONAL AND AESTHETIC FEATURES

Resumen de: US20260306247A1

A prosthetic eye or aesthetic contact lens and methods of manufacture of the same using additive manufacturing. Methods may include scanning a functional eye of a user to generate a prosthetic eye model matching the coloring and sizing features of the scanned eye. A substrate is positioned relative to one or more print heads, which deposit polymerizable mixtures as deposited droplets to form the sclera portion, vein pattern, and iris structure. A first polymerizable mixture may replicate a natural sclera, a second polymerizable mixture may form natural features, such as vein patterns, and a third polymerizable mixture may create an iris with a pupil region. The prosthetic eye may include an internal cavity filled with a liquid solution to allow iris movement, liquid pouches for hydration or medication, and integrated electronic components such as cameras, sensors, and wireless communication modules.

SYSTEM AND METHOD FOR DIRECT AUGMENTED REALITY MEDICAL REGISTRATION

Resumen de: US20260306189A1

0000 Systems and methods for augmented reality medical guidance using multi-stage registration, multi-modal visualization, and dynamic compensation are disclosed. A multi-stage registration method establishes coordinate transformations between a tracking system, an augmented reality system, and a patient's anatomy through device-level registration and anatomical registration. Multiple registration approaches are supported including manual, automated, optical, stylus-based, fiducial-based, surface-based, ultrasound-based, and landmark-based registration. A multi-modal visualization method fuses real-time ultrasound imaging with medical imaging data, displaying holographic content including ultrasound flashlight visualization, texture overlays, edge map fusion, and comprehensive guidance information such as holographic light rays and multi-planar reconstruction slices.

EARLY DETECTION OF NEUROCOGNITIVE DECLINE USING MULTI-MODAL MOBILE-DEVICE BASED ASSESSMENT OF PERSONAL PHOTO INTERACTIONS

Resumen de: US20260311886A1

A method performed by a mobile computing device may comprise accessing, by a mobile computing device, a plurality of personal photographs associated with a user of the mobile computing device. The method further may comprise executing, by the mobile computing device, at least a portion of a multi-activity neurocognitive assessment of a user of the mobile computing device. The multi-activity neurocognitive assessment may include repeatedly collecting multi-modal interaction data by a plurality of sensors of the mobile computing device. The multi-modal interaction data may result from engagement, by the user, with a plurality of personalized neurocognitive activities generated by the mobile computing device using the plurality of personal photographs. The method may further comprise triggering, by the mobile computing device, detection of deviation from a baseline indicative of potential neurocognitive change in the user, the detection being based on evaluation of the collected multi-modal interaction data.

POD CHAMBER FOR IMMERSING A USER IN A MULTISENSORY EXPERIENCE DELIVERED IN CONCERT WITH AN AUDIO BEAT FREQUENCY

Resumen de: AU2025237083A1

Techniques are disclosed for a pod chamber for immersing a user in a multisensory experience delivered in concert with an audio beat frequency generated by a first set of audio speakers positioned on each side of the user's head. A second set of audio speakers delivers an audio performance in concert with the audio beat frequency. A stroboscopic light source provides a strobing pattern of light also in concert with the audio beat frequency as well as with the audio performance. Additional input from tactile transducers is also delivered in concert with the audio beat frequency and the audio performance. Still other elements, such as pulsed electromagnetic field generator, olfactory aromatic diffuser and screens with visuals are provided in the pod chamber to achieve immersion in the multisensory experience and more specifically to induce in the user a sense of participation in the multisensory experience.

ANATOMY RECONSTRUCTION AND IMAGING TASKS BASED ON MANUAL MOVEMENT OF IMAGING DEVICES

Resumen de: AU2025232754A1

A process includes sequentially capturing radiographic images of patient anatomy based on manual movement of an imaging device. The manual movement provides different radiographic projections that correspond to the capture of the radiographic images, and the sequentially capturing monitors the movement of the imaging device and records positional information of the imaging device. The process also includes reconstructing the patient anatomy based on the captured radiographic images and the recorded positional information, to provide a three-dimensional (3D) model of the patient anatomy. The process registers the 3D model to the patient anatomy as reflected in the radiographic images, and builds and outputs an interface that includes the 3D model registered to the patient anatomy reflected in at least one radiographic image, which is a radiographic image of the radiographic images or is a radiographic image obtained subsequent to the sequentially-capturing.

RECOMBINANT HYBRID PROTEIN AND ITS USE

Resumen de: AU2025225813A1

The invention relates to a recombinant hybrid protein REC2z with a structure as defined in the description, recombinant DNA sequences encoding this protein, vectors containing the recombinant DNA sequences, and eukaryotic and prokaryotic expression systems using the in vitro recombinant DNA sequences described below. The invention also relates to the use of the recombinant hybrid protein REC2z as a component of bioink for bioprinting and also as a component of biomaterials. In addition, the invention relates to the use of recombinant DNA sequences, expression vectors and expression systems to produce the recombinant hybrid protein REC2z. The invention finds applications in bioprinting, medicine and cell and tissue engineering.

EDIBLE-BODY MARKING DEVICE AND METHOD THEREFOR

Resumen de: US20260307172A1

0000 An edible-body marking device (1) has a carrier device (20) that carries an edible body, a detection part (210) that detects the edible body, and a laser processing part (220) that forms a marking pattern on the edible body by using laser light. The carrier device sequentially carries the edible body to the detection part (210) and the laser processing part (220). The detection part images (210) the edible body to acquire orientation information regarding an orientation of the edible body, and the laser processing part (220) has a memory part that stores in advance multiple pieces of marking procedure information regarding formation procedures of the marking pattern in association with their respectively different pieces of the orientation information, and forms the marking pattern on the edible body according to the marking procedure information extracted from the memory part based on the orientation information acquired by the detection part (210).

DOUBLE NETWORKED 3D-PRINTED BIOMATERIALS

Resumen de: US20260306707A1

A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.

MULTI-CHANNELED AND GUIDED INNER CONTROLLING (MAGIC) PRINTHEADS

Resumen de: US20260307330A1

0000 Described are techniques, systems, and methods including those employing multi-channel controlled pneumatic printheads which contain a linker (e.g. Luer lock), a designed functional system (e.g., a microfluidic system, coaxial system, bi/tri-axial, or a mixing system), and one or more outlets (e.g., nozzle part or output linker). The printheads are useful for pneumatic, pressure assisted, extrusion-based 3D printing and emulsion/mixture evaporation for fabricating particles that may encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer.

REGION-BASED MOTION CORRECTION USING EXTRA MODAL INFORMATION FOR SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY

Resumen de: US20260311848A1

0000 For correction of motion in single photon emission computed tomography (SPECT) imaging, extra modal information is used to delineate different regions in a patient. Motion in these different regions as reflected in SPECT data is determined. These regional motions are used for motion correction. Statistical measurements for the SPECT data of the different regions may be used to weight the regional motions.

INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING PROGRAM, AND INFORMATION PROCESSING METHOD

Resumen de: US20260305934A1

An information processing apparatus that is communicably connected with another information processing apparatus, the information processing apparatus comprises: a processor configured to execute a program; and a storage device configured to store the program, the processor being configured to execute: acquisition processing of acquiring agreement information relating to the usage of subject eye image data of a patient by the other information processing apparatus; and transmission processing of transmitting the subject eye image data to the other information processing apparatus on the basis of the agreement information acquired by the acquisition processing.

MIST INHALER DEVICES

Resumen de: EP4819150A2

0001 A mist inhaler device (200) for generating a mist comprising a therapeutic for inhalation by a user. The device comprises a mist generator device (201) and a driver device (202). The driver device (202) is configured to drive the mist generator device (201) at an optimum frequency to maximise the efficiency of mist generation by the mist generator device (201).

SCAFFOLDS BASED ON CONTINUOUS FOLDED SHEETS

Resumen de: WO2025117862A1

Provided herein are various embodiments related to the design, creation, and use of a folded sheet scaffold for medical devices. The scaffold comprises a shellular porous pseudorandom orientable architecture composed of a continuous folded sheet of topological genus-n. Methods for designing the scaffold involve driving noise from an infinite 3D noise field to define a field with real space, tuning field values based on user input, and subtracting to create thin wall geometry. The methods can be computer-implemented or executed by a processor following instructions stored on a non-transitory computer-readable medium. A computer system for designing the scaffold includes modules for noise-driving, tuning, and subtracting. The disclosure also includes a folded sheet scaffold formed by these methods and a medical device comprising the folded sheet scaffold.

HELMET FOR NONINVASIVE BRAIN STIMULATION

Resumen de: WO2025111627A1

The invention relates to a helmet (1) for a noninvasive brain stimulation, comprising a stimulation unit (3) oriented towards a head-receiving area (2). In order to allow an individually determinable stimulation region to be precisely irradiated while nevertheless allowing the test person to have a certain degree of mobility, a suction opening (4) is proposed which is open towards the head-receiving area (1) and which is fluidically connected to a negative pressure connection (6) positioned outside of the head-receiving area (2).

BIOCOMPATIBLE GRANULE STRUCTURES

Resumen de: WO2025117313A1

The present disclosure provides biocompatible granule structures and associated assemblies and methods. These biocompatible granule structures are introduced into a void or space in a bone structure or between bone structures disposed on a flexible elongate structure to partially fill the volume and promote bony ingrowth and healing in a variety of surgical applications, such as kyphoplasty and vertebroplasty procedures and the like. The biocompatible granule structures are made of a bony substance or a biocompatible metallic, ceramic, or polymeric material and provide superior migration, interlocking behavior, and bony purchase and ingrowth properties.

POLYETHER-CONTAINING POLYMERIZABLE COMPOUNDS AND USE IN CURABLE RESIN COMPOSITIONS

Resumen de: WO2025117528A1

This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.

LASER MARKABLE RESIN COMPOSITIONS FOR ORTHODONTIC APPLIANCES

Resumen de: WO2025117572A1

This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.

ORAL DEVICE AND METHODS OF PRODUCING AND USING SAME

Nº publicación: EP4815896A1 07/10/2026

Solicitante:

THE BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECH COLLEGES [US]
The Board of Regents for the Oklahoma Agricultural And Mechanical Colleges

Resumen de: WO2025117762A1

An oral device configured for delivery of a liquid to the mouth of the subject is disclosed, along with kits and systems containing same, and methods of producing and using same. The oral device includes a base component comprising a reservoir that is configured for receiving a volume of liquid and contains a wicking agent disposed therein that dispenses liquid via capillary action. The base component also includes at least one opening formed therein for delivery of the liquid to the subject.