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一种跨尺度梯度结构的制备方法、骨修复材料及应用方法

NºPublicación:  CN121422296A 30/01/2026
Solicitante: 
四川大学
CN_121422296_PA

Resumen de: CN121422296A

本发明属于骨修复材料技术领域,公开一种跨尺度梯度结构的制备方法、骨修复材料及应用方法。制备时先将半导体生物材料制成生物异质结悬浮液,再与光固化水凝胶混合形成体系;将骨植入体基材与导电材料分别作为正负电极置于体系中,施加电场使生物异质结粒子定向沉积形成梯度,经光固化固定得带跨尺度梯度结构的骨修复材料,可按需预置多孔支架。该方法制得的材料模仿人体骨骼天然梯度结构,兼具导电、抗菌等复合功能,能兼顾力学支撑与生物活性,适配脊椎修复、肿瘤术后骨缺损等场景,解决传统骨修复材料结构不匹配、功能单一的问题,提升骨整合效率与临床安全性。

3D打印用树脂及其制备方法和用途与光固化性树脂组合物及其固化物

NºPublicación:  CN121427008A 30/01/2026
Solicitante: 
清华大学
CN_121427008_PA

Resumen de: CN121427008A

本发明涉及一种3D打印用树脂及其制备方法和用途与光固化性树脂组合物及其固化物。该3D打印用树脂的制备方法包括:(1)使得氨基葡萄糖硫酸盐类化合物与(甲基)丙烯酰卤进行反应,以得到包含氨基葡萄糖(甲基)丙烯酰胺的反应混合物;(2)将所述反应混合物与包含(甲基)丙烯酸甲酯的有机化合物接触,并从所得的接触混合物中提取有机相,(3)将所述有机相与光固化性化合物进行混合,相对于所述3D打印用树脂的总质量100质量%,所述氨基葡萄糖(甲基)丙烯酰胺的含量为3质量%以上且10质量%以下。

一种3D打印相变导热温度监控贴片的制备方法

NºPublicación:  CN121427135A 30/01/2026
Solicitante: 
郑州市中心医院
CN_121427135_A

Resumen de: CN121427135A

本申请提供了一种3D打印相变导热温度监控贴片的制备方法,涉及温度监控贴片技术领域,包括以下组分:石墨烯、羧基化碳纳米管、海藻酸钠、月桂酸和硬脂酸。本发明通过利用石墨烯、羧基化碳纳米管、海藻酸钠、月桂酸和硬脂酸制备多重氢键作用,互锁相变材料,调控配方中的组分和3D打印工艺参数,制备了一种适配3D打印的流变性需求的配方,并且能够让碳材料有合适的取向流,在较低的含量下实现导热和导电,具有高精度的成型控制,有较好的人体舒适性和较高的温度响应性。

一种具有梯度多孔结构和分区改性表面的钛合金口腔种植体及其制备方法

NºPublicación:  CN121422295A 30/01/2026
Solicitante: 
河北工业大学
CN_121422295_PA

Resumen de: CN121422295A

本发明属于生物医用材料与口腔种植技术领域,具体涉及一种具有梯度多孔结构和分区改性表面的钛合金口腔种植体及其制备方法。种植体总体分为上下两区域,下区域采用创新三级梯度多孔结构,颈缘区为小孔,中部过渡区为中孔,根区为大孔;实现种植体嵌入颌骨部位后弹性模量从冠部到根部的逐步降低,与天然牙槽骨力学性能相匹配,有效降低应力屏蔽效应。种植体表面通过飞秒激光技术进行分区改性处理,上区域处理后显著促进小鼠成纤维细胞的粘附和增殖;下区域处理后形成特定的微纳米复合结构,可显著提高成骨细胞的增殖率和碱性磷酸酶活性。本发明通过结构‑功能一体化设计,同时实现力学适配性优化、软组织封闭性增强和骨结合效能提升。

METHOD FOR PRODUCING AN INTRAORAL SLEEP RESTORATION DEVICE IN ANALOGUE, SEMI-DIGITAL, AND DIGITAL SYSTEMS, INTRAORAL DEVICE, AND POSITIONING JIG FOR INTRAORAL DEVICES

NºPublicación:  WO2026020212A1 29/01/2026
Solicitante: 
BARBOSA DENISE [BR]
BARBOSA, Denise
WO_2026020212_PA

Resumen de: WO2026020212A1

The present invention pertains to a method for producing an intraoral device in analogue, semi-digital, and digital systems, by means of a positioning jig for gnatostatic models for making intraoral devices. In the analogue system, the hinge articulator is replaced by the Gnatoforo HT AS in the gnatostatic study and working models, alongside transfer guides of the Camper's Plane (CP) with rods of the positioning jig for intraoral devices, referred to as AS-DIORS. The semi-digital system reduces the number of steps from ten to seven, beginning with a CT scan of the cranium in maximum intercuspation and intraoral scanner, or MPTv. The digital system produces the DIORS in three steps: CT scan of the cranium in maximum intercuspation and intraoral scanner MPTv, processing the 3D images for making gnatostatic models in maximum intercuspation with MPTv, printing of the gnatostatic models, and finally 3D printing of the DIORS.

RECOATING SYSTEM INCLUDING MOVING BLADE

NºPublicación:  US20260027773A1 29/01/2026
Solicitante: 
ALIGN TECH INC [US]
Align Technology, Inc
US_20260027773_PA

Resumen de: US20260027773A1

A system includes a build platform configured to support an object that is being formed from layers of resin. The system further includes one or more blades configured to provide the layers of resin to form the object on the build platform. At least a first blade of the one or more blades is configured to vibrate to reduce viscosity of the layers of resin.

FIBER-HYDROGEL COMPOSITE MATERIALS FOR FORMING SELF-SUPPORTING STRUCTURES, METHODS OF FORMING SELF-SUPPORTING STRUCTURES

NºPublicación:  WO2026025109A1 29/01/2026
Solicitante: 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
WO_2026025109_PA

Resumen de: WO2026025109A1

Some embodiments provide methods for forming self-supporting, three-dimensional structure by extrusion of a fiber-hydrogel composite material that is solid prior to extrusion, liquifies under stress during extrusion, and resolidifies after extrusion to form the self-supporting, three-dimensional structure. No support bath, no coagulating bath and no cross-linking bath are used during extrusion of the fiber-hydrogel composite material to form the three-dimensional self-supporting structure. In some embodiments, the self-supporting, three-dimensional structure is a tissue scaffold. In some embodiments, the resulting self-supporting three-dimensional structure is edible.

ENDOSCOPIC PRINTHEAD FOR BIOPRINTING

NºPublicación:  US20260026926A1 29/01/2026
Solicitante: 
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV [CA]
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
US_20260026926_PA

Resumen de: US20260026926A1

An endoscopic printing device comprising: a printing head having: a nozzle for outputting a biomaterial; a central conduit connectable to a source of the biomaterial and connected to the nozzle, the central conduit being flexible; ribs disposed around the central conduit and spaced apart from one, a rib of the ribs defining three or more guiding apertures extending axially through the rib, the ribs being interconnected to one another; and cables extending through the guiding apertures, ends of the cables attached to the central conduit, the cables configured to be engaged to an actuator for controlling motion of the endoscopic printing head; and an actuation system engaged to the cables, the actuation system including actuators each engaged to a respective one of the cables, the actuators operable to vary a tension in one or more of the cables relative to a remainder of the cable to bend the central conduit.

METHODS OF DESIGNING AND MANUFACTURING CUSTOM-FIT WEARABLE DEVICES

NºPublicación:  US20260026955A1 29/01/2026
Solicitante: 
XO ARMOR TECH INC [US]
XO Armor Technologies, Inc
US_20260026955_PA

Resumen de: US20260026955A1

Methods and systems are disclosed for manufacturing a custom-fit wearable device. In general, the methods and systems include generating a three-dimensional model of a body portion, identifying one or more anatomical landmarks, and mapping a curve onto the model based at least in part on those landmarks to define a continuous surface. Thickness and an offset may be applied to the surface. The resulting model may then be used to control an additive manufacturing process to produce the custom-fit wearable device.

METHOD OF USING A POWERED STAPLING DEVICE

NºPublicación:  US20260026804A1 29/01/2026
Solicitante: 
CILAG GMBH INT [CH]
Cilag GmbH International
US_20260026804_PA

Resumen de: US20260026804A1

A surgical stapling assembly is disclosed. The surgical stapling assembly can include a first jaw, a second jaw, an articulation joint, a closure drive comprising a first flexible rotary drive extending through the articulation joint, and a firing drive comprising a second flexible rotary drive extending through the articulation joint and rotatable independent of the first flexible rotary drive. The surgical stapling assembly can further include a 3D-printed component.

PHOTOPOLYMERIZATION INITIATOR

NºPublicación:  US20260027035A1 29/01/2026
Solicitante: 
KJ CHEMICALS CORP [JP]
KJ Chemicals Corporation
US_20260027035_A1

Resumen de: US20260027035A1

An object of the present invention is to provide a photopolymerization initiator that is hardly affected by inhibition by oxygen, has good photoinitiating property in air, has high sensitivity to long-wavelength light, and can suppress odor and bleed-out problems of a cured product to be obtained. A photopolymerization initiator having one or more benzophenone groups and one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms in a molecule, wherein one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms are bonded to one or more carbon atoms of an aryl group of one or more benzophenone groups through a carboxylic acid ester group or a carboxylic acid amide group.

LASER ABLATION/REMOVAL AND LASER INDUCED FORWARD TRANSFER OF BIOLOGICAL MATERIAL

NºPublicación:  US20260027262A1 29/01/2026
Solicitante: 
PHOSPRINT P C [GR]
PhosPrint P.C
US_20260027262_PA

Resumen de: US20260027262A1

A method for cell printing is disclosed. The method includes generating a receiver substrate, ablating or removing a portion of the receiver substrate via a first laser to expose a target layer, generating a donor substrate containing a back surface and a front surface, applying a coating of donor material to the front surface. The method further includes aligning the front surface of the donor substrate to be parallel to and facing the receiver substrate, wherein the donor material is disposed adjacent to the target layer, and irradiating the coating through the back surface of the donor substrate with one or more laser pulses produced by a second laser to transfer a portion of the donor material to the target layer. A system for cell printing is also disclosed.

METHOD OF MANUFACTURING A BIORESORBABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE USING A 3D PRINTER AND BIORESORBABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE

NºPublicación:  WO2026022121A1 29/01/2026
Solicitante: 
UNIV POLITECNICA DE CATALUNYA [ES]
UNIVERSITAT POLITECNICA DE CATALUNYA
WO_2026022121_PA

Resumen de: WO2026022121A1

A method of manufacturing a bioresorbable polymeric intravascular tubular device using a 3D printer and a bioresorbable polymeric intravascular tubular device are provided. The method comprises patterning a linear micropattern design comprising different periodicities ranging from 3 μm to 32 μm and a given depth onto a surface of a steel rod; dispensing, while the steel rod is rotating, a polymer-based ink on the generated linear micropattern using a nozzle of a 3D printer; and obtaining a bioresorbable intravascular device with an inner biomimetic topography through solidification of the polymer-based ink.

SUPRASTRUCTURE, DENTAL PROSTHESIS, AND METHOD FOR PRODUCING A DENTAL PROSTHESIS

NºPublicación:  WO2026022080A1 29/01/2026
Solicitante: 
TRI DENTAL IMPLANTS INT AG [CH]
TRI DENTAL IMPLANTS INT. AG
WO_2026022080_PA

Resumen de: WO2026022080A1

The invention relates to a suprastructure (14) for a dental prosthesis (10), comprising: a tooth-crown main body (24) which carries at least one artificial tooth crown; a positioning body (26) having a through-opening for receiving a fastening means (16) for indirectly or directly fastening the suprastructure (14) to a dental implant (12); and a coupling device which captively couples the positioning body (26) to the tooth-crown main body (24) and is designed to allow for a relative movement of the positioning body (26) relative to the tooth-crown main body (24).

IN SITU THERAPEUTIC PRODUCTION: METHODS AND COMPOSITIONS

NºPublicación:  AU2024312714A1 29/01/2026
Solicitante: 
WILLIAM MARSH RICE UNIV
WILLIAM MARSH RICE UNIVERSITY
AU_2024312714_PA

Resumen de: AU2024312714A1

This disclosure is directed to compositions of engineered cells that are incorporated into immunomodulatory substances that act as semi-permeable membranes. These compositions provide for sustained delivery of various biologic and therapeutic molecules, such as cytokines or monoclonal antibodies, for a range of diseases, including infectious diseases, cancer immunotherapy and auto-immune disorders.

MICROFLUIDIC 3D-PRINTED HYDROGEL BASED ON FISH LIVER DECELLULARIZED EXTRACELLULAR MATRIX, AND PREPARATION METHOD THEREFOR AND USE THEREOF

NºPublicación:  WO2026020671A1 29/01/2026
Solicitante: 
NANJING DRUM TOWER HOSPITAL [CN]
\u5357\u4EAC\u9F13\u697C\u533B\u9662
WO_2026020671_PA

Resumen de: WO2026020671A1

A microfluidic 3D-printed hydrogel based on fish liver decellularized extracellular matrix for liver regeneration and a preparation method. The hydrogel is prepared by means of combining fish liver decellularized extracellular matrix (dECM) and gelatin methacryloyl (GelMA), and loading induced pluripotent stem cell-derived hepatocytes (iPSC-heps) for liver regeneration. The microfluidic 3D-printed hydrogel based on fish liver decellularized extracellular matrix exhibits excellent biocompatibility, retains intact endogenous growth factors, maintains the biological activity of cells, ensures the effective encapsulation of the cells, and facilitates the robust functional expression of the iPSC-heps. After in-vivo transplantation, the survival rate and liver function of mice with acute liver failure are significantly improved, and liver regeneration and repair are promoted.

Curable Composition for Producing Transparent Orthodontic Attachments

NºPublicación:  US20260028440A1 29/01/2026
Solicitante: 
SOLVENTUM INTELLECTUAL PROPERTIES COMPANY [US]
Solventum Intellectual Properties Company
US_20260028440_PA

Resumen de: US20260028440A1

The invention relates to a curable composition comprising a (meth)acrylate not comprising an urethane moiety, an urethane (meth)acrylate, photo-initiator, discrete filler particles having an average particle size in the range of 10 to 40 nm, having been surface treated with a silane surface treating agent selected from a silane surface treating agent comprising a (meth)acrylate moiety, a silane surface treating agent not comprising a (meth)acrylate moiety, and a mixture of both, and the discrete filler particles being present in an amount of 20 wt. % or more, the curable composition further comprising additives, the curable composition not comprising the following components alone or in combination: aggregates of nano-sized particles, agglomerates of nano-sized particles, fumed silica, each in an amount of 2 wt. % or more, wt. % with respect to the curable composition.

SUPPORTED POLYMERIZATION INHIBITORS AND THEIR USE IN CURABLE COMPOSITIONS FOR 3D PRINTING

NºPublicación:  US20260028489A1 29/01/2026
Solicitante: 
ALIGN TECH INC [US]
Align Technology, Inc
US_20260028489_PA

Resumen de: US20260028489A1

The present disclosure provides curable compositions comprising polymerization inhibitor-functionalized particles to prevent undesired polymerization of the polymerizable compounds in the curable compositions during their transportation, handling or storage, or during 3D printing processes. Such curable compositions can be used to produce polymeric materials with properties suitable for use in various 3D printed objects, such as orthodontic appliances.

SYSTEMS AND METHODS FOR AUTOMATED SEGMENTATION OF PATIENT SPECIFIC ANATOMIES FOR PATHOLOGY SPECIFIC MEASUREMENTS

NºPublicación:  US20260031238A1 29/01/2026
Solicitante: 
AXIAL MEDICAL PRINTING LTD [GB]
Axial Medical Printing Limited
US_20260031238_PA

Resumen de: US20260031238A1

Systems and methods are provided for multi-schema analysis of patient specific anatomical features from medical images. The system may receive medical images of a patient and metadata associated with the medical images indicative of a selected pathology, and automatically classify the medical images using a segmentation algorithm. The system may use an anatomical landmark detection algorithm leveraging Deep Reinforcement Learning (DRL) techniques to automatically locate one or more anatomical landmarks associated with the patient specific anatomical feature within the medical images. A 3D surface mesh model may be generated representing the patient specific anatomical features including the located one or more anatomical landmarks. The located one or more anatomical landmarks may be used to guide placement of a 3D model of a medical device that may be fused with the 3D surface mesh model to generate a patient specific 3D model of the medical device.

API装填組織貫通器を介して薬物を送達するためのデバイス及び方法

NºPublicación:  JP2026503756A 29/01/2026
Solicitante: 
ヤンセンバイオテツク,インコーポレーテツド
JP_2026503756_PA

Resumen de: CN120641167A

A drug delivery device comprises at least one tissue penetrating member configured to be embedded in tissue, the at least one tissue penetrating member comprising: a plurality of lumens, and at least one payload comprising at least one active pharmaceutical ingredient (API) loaded into the plurality of lumens, the at least one tissue penetrating member is configured such that when the at least one tissue penetrating member is embedded in the tissue, the at least one API can be absorbed into the tissue wherein a ratio of a surface area of the plurality of lumens to a volume of the plurality of lumens is at least 0.5: 1.

NERVE GRAFTS FOR PERIPHERAL NERVE REGENERATION

NºPublicación:  EP4683685A1 28/01/2026
Solicitante: 
VERIGRAFT AB [SE]
VeriGraft AB
US_2024342342_PA

Resumen de: US2024342342A1

The present disclosure generally relates to nerve grafts (e.g., allografts), particularly to methods of preparing immunologically anonymized nerve segments and methods of preparing personalized nerve grafts. The present disclosure also provides methods of regenerating a nerve defect.

POST-PROCESSING OF BIOLOGICAL SCAFFOLDS

NºPublicación:  EP4683684A1 28/01/2026
Solicitante: 
LUNG BIOTECHNOLOGY PBC [US]
Lung Biotechnology PBC
CN_121175081_PA

Resumen de: AU2024238878A1

A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.

METHOD OF MANUFACTURING A BIODEGRADABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE USING A 3D PRINTER AND BIODEGRADABLE POLYMERIC INTRAVASCULAR TUBULAR DEVICE

NºPublicación:  EP4684765A1 28/01/2026
Solicitante: 
UNIV CATALUNYA POLITECNICA [ES]
Universitat Polit\u00E8cnica De Catalunya
EP_4684765_PA

Resumen de: EP4684765A1

A method of manufacturing a biodegradable polymeric intravascular tubular device using a 3D printer and a biodegradable polymeric intravascular tubular device are provided. The method comprises patterning a linear micropattern design comprising different periodicities ranging from 3 µm to 32 µm and a given depth onto a surface of a steel rod; dispensing, while the steel rod is rotating, a polymer-based ink on the generated linear micropattern using a nozzle of a 3D printer; and obtaining a biodegradable intravascular device with an inner biomimetic topography through solidification of the polymer-based ink.

PERIODONTAL TISSUE REGENERATION MATERIAL

NºPublicación:  EP4685229A1 28/01/2026
Solicitante: 
CYFUSE BIOMEDICAL KK [JP]
UNIV HIROSHIMA [JP]
Cyfuse Biomedical K. K,
Hiroshima University
EP_4685229_A1

Resumen de: EP4685229A1

There is a demand for establishing a technique for realizing tissue regeneration even in cases of severe periodontal tissue loss. The present invention provides a periodontal tissue regeneration material for grafting, which contains graft tissue containing mesenchymal stem cells and collagen secreted from the mesenchymal stem cells. The graft tissue each include 2 × 10<sup>5</sup> or more cells, and have a projected area equivalent circle diameter or a thickness of 1 mm or more.

TRANSALVEOLAR DENTAL IMPLANT AND METHOD OF MANUFACTURE

Nº publicación: ES3053963T3 28/01/2026

Solicitante:

INDIVIDUAL IMPLANT SOLUTIONS INC
Individual Implant Solutions, Inc

EP_4659703_PA

Resumen de: EP4659703A2

The present disclosure relates to single tooth or full arch dental restoration. In cases where patients have insufficient bone stock for conventional root-form dental implants, current solutions often fail to restore function. The present disclosure describes a transalveolar dental implant for single tooth or full arch dental restoration. The transalveolar dental implant is comprised of a post and a bone plate, the bone plate having a contoured portion fabricated to match the topography of a bony surface of the facial skeleton. Through primary fixation of the contoured portion of the bone plate, the transalveolar dental implant improves function and outcomes in affected patients.

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