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一种基于梯度蒸汽爆破的低分子量海藻酸钠制备方法及其应用

Resumen de: CN122685766A

本发明公开了一种低分子量海藻酸钠的制备方法、产品及其应用，属于生物高分子材料改性技术领域。本发明针对现有海藻酸钠降解法存在分子量分布宽、活性基团易破坏的技术问题，提供了一种"低温等离子体活化—梯度蒸汽爆破—负压重组"三级物理场耦合的制备方法。该方法包括：将海藻酸原料在含氧气氛中进行低温等离子体活化预处理；然后进行至少两级压力依次升高的梯度蒸汽爆破；再在负压环境下进行分子链重组；最后经中和、离心和干燥得到低分子量海藻酸钠。本发明制备的海藻酸钠重均分子量为20‑50kDa，分子量分布指数PDI≤1.5，1%水溶液透光率≥90%，可用于生物3D打印和药物控释载体。

一种基于先进生物打印技术辅助的声带修复装置

Resumen de: CN122681624A

一种基于先进生物打印技术辅助的声带修复装置，包括：成像定位部件，含内窥镜成像模块和三维重建处理器；手术操作部件，含声门暴露机构和象鼻式柔性机械臂，声门暴露机构暴露声门提供视野，机械臂高精度操作；生物修复部件，含微型打印头、相容性水凝胶、注射管及运动控制机构，实现声带重建与功能恢复。通过集成生物打印部件与成像定位部件，系统能够精确获取声带损伤区域的三维结构数据，并实现生物材料的毫米级精准沉积，使成像定位的毫米级精度、机械臂的微米级操作与生物材料的可控打印形成闭环反馈系统，提升声带修复的整体成功率，实现声带修复从"经验性操作"到"精准工程"的跨越，为声带功能障碍患者提供了更安全有效的治疗选择。

一种钛基超弹性形状记忆合金及其制备方法和应用

Resumen de: CN122687002A

本发明提供了一种钛基超弹性形状记忆合金及其制备方法和应用，属于合金技术领域。钛基超弹性形状记忆合金为TiMAlX合金，按照原子百分比计，M：29~41%，Al：18~26%，X：0.9~5.1%；其余为Ti和不可避免的杂质；其中，M为Zr和/或Nb，X为Mo、Ni、Fe、V、Cr、Mn或Ta中的一种或几种。本发明的钛基超弹性形状记忆合金中，混合焓较负的Al元素的含量较高，而且添加了特定的X元素作为强β稳定元素，在室温下，合金主要为B2母相；在外加载荷作用下发生应力诱导马氏体相变，形成B19马氏体相，从而产生可恢复变形。

具有集成读出的传感器阵列

Resumen de: TW202532824A

A deformable sensor array may include a plurality of sensors and a flexible substrate. Each sensor of the plurality of sensors may include a sensor die to generate an analog signal and an converter die to perform analog-to-digital conversion (ADC) of the analog signal to generate a digital output. The flexible substrate may include electrical interconnect coupled with the plurality of sensors, and strain relief cutouts between sensors of the plurality of sensors and between the electrical interconnect, to enable deformation of the plurality of sensors. Other aspects are also described and claimed.

一种3D打印碳纤维复合儿童下肢矫形器及其制备方法

Resumen de: CN122681633A

本发明涉及矫形器技术领域，公开了一种3D打印碳纤维复合儿童下肢矫形器及其制备方法，包括基底和侧连接架，基底和侧连接架采用3d打印一体成型设置，基底和侧连接架的外壁均粘接有碳纤维强化布，3粘接在基底、侧连接架的外壁后形成完整的矫形器，矫形器为贴合儿童下肢畸形轮廓的一体化薄壁壳体结构，本发明通过设置有采用薄壁3d打印基底加碳纤维布覆膜复合结构，摒弃传统矫形器厚壁补强的方式，基底壳体超薄设计，碳纤维层轻量化强化，整体厚度大幅降低，重量较传统矫形器减轻百分之四十至百分之六十，同时结构强度、刚性、抗冲击性大幅提升，不易变形开裂，解决现有产品轻薄度与强度无法兼顾的行业痛点。

一种基于3D打印的聚二甲基硅氧烷异质双层引导骨再生膜及其制备方法

Resumen de: CN122682109A

本发明属于生物医用材料与组织工程领域，涉及一种基于3D打印的聚二甲基硅氧烷异质双层引导骨再生膜及其制备方法。所述方法包括采用一步法合成镓掺杂锌基金属有机框架材料GZM和铜掺杂锌基金属有机框架材料CZM并进一步进行二氧化硅包覆改性，然后将改性填料制备为复合墨水，通过3D打印得到具有双层异质结构的膜材料。本发明的双层引导骨再生膜具备良好的机械支撑能力与柔性适配能力以及良好的抗菌性能与促骨再生能力。

一种增材制造用模型树脂及其制备方法和在3D打印制备牙科模型中的应用

Resumen de: CN122685815A

本发明涉及高分子材料领域，具体而言，涉及一种增材制造用模型树脂及其制备方法和在3D打印制备牙科模型中的应用,按质量份数计，包括以下原料：乙氧化双酚A二甲基丙烯酸酯35‑42份、三乙二醇二甲基丙烯酸酯35‑50份、脂肪族聚氨酯丙烯酸甲酯10‑20份、苯基双(2,4,6三甲基苯甲酰基)氧化膦1‑5份。将各原料加入到容器中，在避光条件下，先在1000‑1500 rpm转速下高速分散15‑30 min，再在300‑400 rpm转速下低速分散5‑15 min，即得到所述树脂。该树脂其粘度适中，3D打印性能优异，分散稳定性好，颜色均匀，表面固化性能和抗老化性能良好。

一种用于治疗糖尿病感染创面的负载碳点水凝胶微针及其制备方法

Resumen de: CN122681777A

本发明涉及一种用于治疗糖尿病感染创面的负载碳点水凝胶微针及其制备方法，首先制备功能化碳点QP‑CD‑2，随后基于所述QP‑CD‑2配置微针前驱液并进行光交联得到QP‑CD‑2@MNs。本发明制备的负载碳点水凝胶微针不仅具有高效的抗菌、抗氧化和抗炎活性，还具有重塑局部免疫微环境并促进创面快速且高质量再生的能力，具有良好的应用前景。

髋臼杯假体以及髋臼杯假体的制备方法

Resumen de: CN122681627A

本发明提供了一种髋臼杯假体以及髋臼杯假体的制备方法，其中，髋臼杯假体包括：金属杯主体，具有内腔以及与内腔连通的开口，开口用于使关节柄假体的球头伸入至内腔内；陶瓷涂层，覆盖在内腔的内壁面上；羟基磷灰石涂层，覆盖在金属杯主体的外壁面上，其中，羟基磷灰石涂层包括叠置设置的多个第一层结构，由远离至靠近金属杯主体的方向上，多个第一层结构的钙磷比逐渐减小。本申请的技术方案能够有效地解决相关技术中的难以兼顾加工工艺和稳定性的问题。

IMPLANTABLE NEURO MODULATOR DEVICE AND SYSTEM COMPRISING SUCH AN IMPLANTABLE NEURO MODULATOR DEVICE

Resumen de: US20260257071A1

An implantable neuro-modulator device, including a hermetically sealed housing, wherein an antenna for communicating with external devices and/or for wirelessly receiving electrical energy is positioned within the housing, wherein a major part of the housing is electromagnetically transparent to radiation in the frequency range below 20 MHz, in particular between 5 and 15 MHz.

Apparatus for monitoring, regulating, or controlling fluid flow

Resumen de: AU2026216825A1

An apparatus, system and method for regulating fluid flow are disclosed. An apparatus for infusing fluid into a patient includes a housing, a tube-contact member, a rotating arm, and a tube-retention cover. The housing has an opening on a front side of the housing. The opening is sized to receive a drip chamber having an inlet tube and an outlet tube. The tube-contact member contacts one of the inlet tube and the output tube of the drip chamber when inserted into the opening. The rotating arm is coupled to the tube-contact member and is configured to rotate along an axis. The tube-retention cover is configured to close when the drip chamber is initially loaded into the opening. tube and an outlet tube. The tube-contact member contacts one of the inlet tube and ug u g t u b e a n d a n o u t l e t t u b e h e t u b e - c o n t a c t m e m b e r c o n t a c t s o n e o f t h e i n l e t t u b e a n d

COMBINED FACE SCANNING AND INTRAORAL SCANNING

Resumen de: US20260256546A1

A system comprises an intraoral scanner, a three-dimensional (3D) image capture device, and a computing device operatively coupled to the intraoral scanner and to the 3D image capture device. The computing device receives intraoral scan data of a dental site of a patient generated by the intraoral scanner during intraoral scanning. The computing device further receives one or more 3D images of a face of the patient generated by the 3D image capture device during the intraoral scanning, wherein the intraoral scanner is captured in the one or more 3D images. The computing device registers the one or more 3D images of the face of the patient to the first intraoral scan data based at least in part on a first position of the intraoral scanner relative to the face of the patient in the one or more 3D images.

CLEAR ORTHODONTIC ALIGNER

Resumen de: US20260256547A1

0000 The present invention relates to a clear orthodontic aligner comprising at least one molecule capable of changing color or color intensity (CCM). Furthermore, the invention relates to a process for obtaining a clear orthodontic aligner by means of three-dimensional (3D) printing.

MULTIMODAL SEIZURE SENSING

Resumen de: US20260256413A1

0000 This disclosure describes systems, apparatuses, and techniques that use of multiple sensing modalities (multimodal sensing) in parallel to improve the detection, classification, and evaluation of seizures in subjects (e.g., mammalian subjects, such as humans). In some implementations, a wearable device includes a flex sensor configured, an inertial motion unit (IMU), and a plurality of surface electromyogram (sEMG) electrodes configured to be placed approximate to a muscle of a subject. The device also includes a microprocessor. The operations performed by the microprocessor include determining multimodal movement data of the muscle, where the multimodal movement data specifies at least an acceleration associated with movement of the muscle, an angular velocity associated with movement of the muscle, and sEMG activity associated with the movement of the muscle. The operation further includes determining whether the multimodal movement data indicates a possible seizure, and provide data based on the determination for output.

SYSTEM AND METHOD FOR ADDITIVE MANUFACTURING USING AN OMNIDIRECTIONAL MAGNETIC MOVEMENT APPARATUS

Resumen de: US20260256701A1

0000 A process system and method for the making of articles, using an omnidirectional magnetic movement system with a transport surface and fabrication modules having a formation surface that can be transported omnidirectionally over the transport surface under the control of a movement controller. An article forming system provides process unit operations for forming articles onto the formation surface as the fabrication modules are moved asynchronously between a plurality of processing positions on the transport surface, and features a depositing device for placing a construction material onto the formation surface and one or more processing devices to form the construction material into the article.

THREE-DIMENSIONAL PRINTING COMPOSITION AND METHOD OF PRODUCING DENTAL PRINTED ARTICLE

Resumen de: US20260256559A1

A three-dimensional printing composition includes: a polymerizable monomer; inorganic particles; and a photopolymerization initiator. The inorganic particles are surface-treated with a compound represented by a general formula (1)(in the general formula, R1 is a hydrogen atom or a methyl group; R2 is a hydrolyzable group; R3 is a hydrocarbon group having 1 or more and 6 or less carbon atoms; p is 2 or 3; and q is an integer of 5 or more and 13 or less).

ROBOTIC SURGICAL SYSTEM AND METHOD FOR USING ARTIFICIAL INTELLIGENCE TO GENERATE SIMULATION AND DECISION SUPPORT FOR TELEOPERATION

Resumen de: US20260256534A1

0000 A robotic surgical system and method for using artificial intelligence to generate simulation and decision support for teleoperation are provided. In one embodiment, the robotic surgical system provides a surgical simulation model with input about a surgical field of a patient and signals generated in response to user-manipulation of the plurality of user input devices to perform a surgical task on the patient. The surgical simulation model generates and displays a video that represents a simulated performance of the surgical task. Other embodiments are provided.

METHODS AND SYSTEMS FOR PREDICTING TREATMENT OUTCOMES, PATIENT SELECTION AND PERSONALIZED THERAPY USING PATIENT RESPONSE PROPERTIES TO SENSORY STIMULATION

Resumen de: US20260256407A1

In some aspects, the present disclosure describes a method of predicting an expected treatment outcome of a subject, comprising administering a gamma oscillation-inducing non-invasive sensory stimulus to the subject, measuring a response from the subject, and predicting, using a machine learning algorithm, the expected treatment outcome of the subject based at least partially on the measured response. In some aspects, the present disclosure also provides methods for personalizing gamma therapy treatment by adjusting parameters associated with the gamma oscillation-inducing non-invasive sensory stimulus based on a subject's response to the gamma oscillation-inducing non-invasive sensory stimulus.

SYSTEMS AND METHODS FOR FABRICATING ORTHODONTIC RETAINERS

Resumen de: US20260256560A1

The present disclosure provides systems and methods for fabricating an orthodontic retainer comprising a retainer base. The methods may include obtaining a first digital model representing the palate and the upper teeth of a patient. The methods may include creating, based on the first digital model, a second digital model representing the retainer base and a third digital model representing a teeth shell, and creating, based on the second digital model and the third digital model, a fourth digital model representing the retainer base and the teeth shell that are connected via a connecting structure. The methods may include generating a printed assembly by printing the fourth digital model using a first curable resin material. The printed assembly may at least include the retainer base, the teeth shell, and the connecting structure. The methods may include post-processing the printed assembly to obtain the retainer base.

EVALUATION METHOD BASED ON ANALYTE DATA AND AN EVALUATION SYSTEM

Resumen de: US20260256430A1

0000 Some embodiments of the disclosure describe an evaluation system based on analyte data including a memory storing a program, a display, and a processor. In some examples, the processor is configured to: receive analyte data during a predetermined time period from an object to be tested, acquire a plurality of analyte indicators different from each other based on the analyte data, normalize the plurality of analyte indicators to a predetermined range to acquire a plurality of normalized analyte indicators, plot a polygon pattern corresponding to the analyte data during the first time period as a target polygon pattern, plot a polygon pattern corresponding to the analyte data during the second time period as a reference polygon pattern, and take a line segment between a vertex and a center point as an axis, and display the target polygon pattern and the reference polygon pattern.

SYSTEMS AND METHODS FOR MANAGING, MONITORING, AND TREATING PATIENT CONDITIONS

Resumen de: US20260260724A1

0000 Systems, devices, user interfaces, and methods for managing patient conditions. A system for monitoring and/or managing a patient suffering from a brain condition may include a controller obtaining and/or storing data related to one or more monitored patient parameters contributing to the brain condition of the patient and displaying values of the one or more monitored patient parameters in trend lines over time on a user interface. The displayed trend lines may represent values of ventricular CSF volume, values of IVH volume, total ventricular volume in the brain, and/or values of other suitable parameters. The data related to the one or more monitored patient parameters may include images of the patient’s brain and/or data derived from images of the patient’s brain and/or suitable patient data.

PATIENT-SPECIFIC VERTEBRAL IMPLANTS WITH POSITIONING FEATURES

Resumen de: US20260256591A1

0000 The present technology provides patient-specific vertebral implants. The implants can include a cage having a geometry contoured to mate with an inferior surface of a superior vertebra and a superior surface of an inferior vertebra at a first target position. The implants can also include a plate having a geometry contoured to mate with an identified anatomical structure at a second target position. The cage and plate can be coupled in a predetermined three-dimensional orientation that simultaneously permits the cage to occupy the first target position and the plate to occupy the second target position when the implant is implanted.

一体型モールド本体を含む歯科修復モールド

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

THERAPEUTIC ZONE ASSESSOR

Resumen de: US20260260729A1

0000 Systems and methods are provided for identifying therapeutic zones where there is glycemic dysfunction of a specific type that can be addressed by making strategic changes to behavior and/or therapy parameters. Systems and methods described herein evaluate large historical data sets to: identify a therapeutic zone or zones with glycemic dysfunction that are most readily addressable; quantify the glycemic impact of a plurality of different therapeutic adjustments in terms of either adjustments to historical doses or the parameters of a prospective dosing strategy to determine the highest possible improvement; and/or identify patient dosing strategies to provide therapy recommendations adapted for the patient’s preferred behavioral dosing strategy.

THERAPY FOR THE TREATMENT OF DISORDERS IN THE NERVOUS SYSTEM BY MEANS OF CLASSIFICATION OF DETECTED TREMORS THROUGH MACHINE LEARNING

Nº publicación: US20260256423A1 03/09/2026

Solicitante:

BIOTRONIK SE & CO KG [DE]
BIOTRONIK SE & Co. KG

Resumen de: US20260256423A1

A method includes receiving data for an episode stored by a medical device of a patient. The episode is associated with a period of time. The data includes an electroencephalogram or data derived from neural activity in the brain sensed by the medical device during the period of time. One or more machine learning models are applied to the data and are configured to output a respective likelihood value for each of a plurality of tremor type classifications. The method further includes, based on the application of the one or more machine learning models to the episode data, deriving, for each of the tremor type classifications, class activation data indicating varying likelihoods of the classification over the period of time; and displaying a graph of the varying likelihoods of the tremor type classifications over the period of time.