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可聚合的聚氨酯和含有该聚氨酯的组合物，用于3D打印牙科材料

Resumen de: US2024352179A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable urethane prepolymers having alternating hard and soft blocks, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

定制耳部设备的自动设计

Resumen de: WO2024200441A1

Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.

一种基于三维扫描的数字化假牙安装定位装置及其方法

Resumen de: CN121074284A

本申请涉及口腔种植引导技术领域，提供了一种基于三维扫描的数字化假牙安装定位装置及其方法。该方法包括：通过口腔扫描仪扫描患者口腔生成三维口腔数字化模型；通过SegFormer分割网络，基于三维口腔数字化模型生成患者的虚拟种植体以及对应的初始植入参数；基于历史手术数据、初始植入参数、骨质密度、患者属性以及咬合力参数，采用长序列预测网络通过分段注意力机制以及网络记忆缓存机制预测虚拟种植体在骨结合后的位置偏移量及骨吸收程度获得最佳植入参数；基于最佳植入参数向用户推送包含候选定位策略的可视化动态模型，驱动口腔模型打印机得到种植导板模型和口腔环境模型，辅助用户验证候选定位策略的安装效果，提升假牙安装定位准确性。

基于动态厚度补偿的透明矫治器动态厚度补偿生产工艺方法

Resumen de: CN121062188A

本发明公开了基于动态厚度补偿的透明矫治器动态厚度补偿生产工艺方法，属于口腔正畸医疗器械制造技术领域，包括以下步骤：S1，获取序列矫治模型；S2，CAE厚度预测；S3，动态调整决策；S4，自适应制造执行：根据步骤S3选用以下任一制造路径生产矫治器：S4（a），梯度成品膜片热成型路径；S4（b），3D打印增材制造路径，该发明具备能确保矫治器的成型厚度一致，且能结合三维动态仿真以及3D打印等多样化生产工艺的优点，解决了现有矫治器的成型厚度不一致、生产工艺较为单一、缺乏三维动态仿真，进而影响矫治器的生物力学表现，并严重制约个性化正畸方案落地实施的问题。

一种基于光聚合3D打印中药防臭矫形鞋垫的制备方法

Resumen de: CN121062211A

本发明公开了一种基于光聚合3D打印中药防臭矫形鞋垫的制备方法，属于足部护理及鞋垫技术领域，为了解决现有中药成分在鞋垫中的分布均匀性欠佳，且容易出现脱落现象，致使防臭性能大打折扣的问题；本发明将粉碎后的中药与光敏树脂混合，并添加分散剂借助其表面活性降低中药颗粒团聚力，确保中药颗粒在光敏树脂中均匀分散，同时，针对足部不同区域的压力特征，通过设置中药层厚度，如前脚掌0.3‑0.5cm、足弓0.2‑0.4cm、足跟0.4‑0.6cm，并结合逐层固化的3D打印特性，保证高压力区域的中药含量充足，提升防臭效果的针对性与持久性，表层采用竹纤维与棉纤维混纺面料，不仅利用竹纤维的高吸湿性快速吸收足部汗液，其天然抗菌性还与中药层形成协同防臭机制，增强防臭性能。

一种基于多材料3D打印构建的医用钳子及其制备方法

Resumen de: CN121059246A

本发明公开了一种基于多材料3D打印构建的医用钳子及其制备方法。包括以下步骤：基于患者医学影像数据或标准器械模型，通过计算机辅助设计软件进行个性化设计，构建一体化三维数字模型；接着进行拓扑优化，在非关键受力区域设计减重结构，并使用切片软件处理生成多材料打印指令文件；然后采用多材料3D打印设备，根据预先设定的材料分配方案，使用具有不同力学性能的材料在所述钳喙、活动关节和钳柄区域同步进行一体化打印，制造出钳子生坯；最后进行清洗、关键部位表面精加工及灭菌处理，得到最终产品。本发明能够根据特殊手术需求，快速设计和制造匹配的钳子，在同一器械上集成多种性能各异的材料，提升手术精准度和效果。

一种用于假牙精准定位的数字化辅助定位装置及方法

Resumen de: CN121074143A

本申请涉及口腔种植引导技术领域，提供了一种用于假牙精准定位的数字化辅助定位装置及方法。该方法包括：获取患者口腔的骨结构数据、软组织数据、以及患者生理数据，形成口腔内部结构数据；通过分割模型对口腔内部结构数据进行分割处理，得到患者口腔内部的牙龈牙齿边界特征模型；基于口腔内部结构数据通过多模态时序预测网络中与患者代谢状态匹配的预测子模型，预测患者在未来预设时长内符合患者代谢状态变化情况的定位偏移量；基于定位偏移量，优化牙龈牙齿边界特征模型中假牙与周围口腔环境之间的空间关系，并基于牙龈牙齿边界特征模型输出假牙定位辅助信息，用以作为口腔模型打印机制作假牙模型的定位参考，提升定位准确性以及长期稳定性。

新型方法

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

歯科補綴部品の製造方法、アダプタ、ブランク、アダプタとブランクのセット、および複数のアダプタのセット

Resumen de: CN119947675A

The invention relates to a method for producing a tooth substitute part (200) that can be connected to a tooth stump (110), in particular a stationary tooth substitute part (200), wherein an adapter (10) for a machine tool and a blank (50) for a tooth substitute part (200) are produced.

一种胫骨近端截骨器具

Resumen de: CN223627552U

本申请涉及医疗器械的技术领域，尤其是涉及一种胫骨近端截骨器具，其包括截骨导板，所述截骨导板包括导板主体和护套，所述护套设于所述导板主体的周向，所述导板主体和所述护套共同覆盖患部胫骨近端端面；克氏针固定孔，设置在导板主体上，用于引导克氏针钉入患者胫骨以固定所述导板主体；髓针定位孔，设置在导板主体上，用于定位假体髓针的位置；刀槽，设置在所述护套上，用于引导截骨工具进行截骨。本申请具有将髓针的定位与截骨两个步骤合二为一，节省手术时间，减少感染概率的效果。

歯科用コンポーネントの製造のための放射線硬化性組成物

Resumen de: US2025361406A1

The invention relates to a radiation-curing composition for the manufacture of dental components using the DLP process or SLA process, comprising, based on the total mass of the radiation-curing composition (i) one or more radically polymerizable monomers in a combined mass fraction of 60% or more, (ii) one or more hexaarylbiimidazole compounds in a combined mass fraction in the range of 0.1 to 5%, and (iii) one or more mercaptotetrazole compounds in a combined mass fraction in the range of 0.1 to 5%, wherein the combined mass fraction of fillers in the radiation-curing composition is less than 30%.

IMPLANT FOR CORRECTING A DEFECT OF A BONE STRUCTURE WITH NAVIGATION FIDUCIALS

Resumen de: JP2024057092A

To provide a system for manufacturing and using an implant for correcting a defect of a bone structure.SOLUTION: The implant includes a first surface comprising a shape configured to interface with a surface of the bone structure. In some examples, the implant includes a second surface opposite the first surface and substantially conformal to the shape of the first surface, the second surface comprising three or more point features on the second surface, wherein the three or more point features comprise a first point feature, a second point feature, and a third point feature that form nodes of a triangle, and each of the three or more point features is recessed below the second surface.SELECTED DRAWING: Figure 5D

ADDITIVE MANUFACTURING SYSTEM, METHOD AND CORRESPONDING COMPONENTS FOR MAKING ELASTOMERIC STRUCTURES

Resumen de: US2025367876A1

A system for additive manufacturing a medical device, the system comprising a first dispensing system, a second dispensing system, a deposition apparatus, and a deposition substrate on a surface of which the deposition apparatus is configured to deposit at least one elastomeric material into a filament. The deposition apparatus receives the at least one elastomeric material from the first and second dispensing systems in proportions effecting a desired property in the medical device. The deposition apparatus may comprise heating and/or cooling elements, a sonic vibration module, and/or a pneumatic suck-back valve. The deposition substrate may have a configuration corresponding to a desired shape of the medical device and is configured to rotate and/or translate relative to the deposition apparatus. The system comprises a controller configured to control the deposition.

Microneedles and Methods of Manufacture Thereof

Resumen de: US2025367422A1

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

3D PRINTING OF 3-LAYERED RETINA AND CHOROID TISSUE

Resumen de: US2025367348A1

A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.

ORTHODONTIC SYSTEMS WITH VARIABLE ATTACHMENT AND WELL GEOMETRIES

Resumen de: US2025366953A1

Systems for orthodontic treatment are provided. In some embodiments, a system includes an attachment configured to be coupled to a tooth of a patient. The attachment can include a first surface configured to contact the tooth, a second surface opposing the first surface, and one or more sidewalls connecting the first surface and the second surface. The first surface, the second surface, and the one or more sidewalls can form a solid enclosed volume having a protruding shape. The system can further include an orthodontic appliance including a shell having a plurality of teeth-receiving cavities shaped to reposition the patient's teeth from a first arrangement toward a second arrangement, and an attachment-receiving well formed in the shell. The attachment-receiving well can engage the attachment to effect a movement of at least one tooth of the patient. The attachment can have a different geometry than the attachment-receiving well.

SEMI-RADIOLUCENT PATIENT-SPECIFIC 3D-PRINTED LATTICE TITANIUM PLATE

Resumen de: US2025366922A1

A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at least four mounting holes. Another aspect of the present disclosure relates to a method for tailoring a plate for fixating bone. The method can include determining an initial design of the plate. The method can include analyzing radiation through the initial design. The method can include determining, based on analyzed radiation, if dosimetric characteristics are desirable. The method can include analyzing structural strength of the initial design. The method can include determining, based on the analyzed structural strength, if structural strength is sufficient.

Validation for Rapid Prototyping Parts in Dentistry

Resumen de: US2025366958A1

Systems and techniques for training one or more neural networks to automatically determine placement of a digital representation of an orthodontic appliance are disclosed including comparing one or more aspects of the second representation of a 3D printed part with one or more respective aspects of a first representation of the 3D printed part, generating a reconstruction error based on the comparing, and when the reconstruction error is greater than a predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were not correctly fabricated and when the reconstruction error is less than the predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were correctly fabricated.

MEDICAL DEVICE BASED ON BIOCERAMICS, ITS USE AS A SYNTHETIC BONE GRAFT AND PROCESS FOR THE PREPARATION THEREOF

Resumen de: US2025366995A1

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: US2025366979A1

Disclosed herein are devices and methods of making and use thereof.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: US2025366978A1

Disclosed herein are devices and methods of making and use thereof.

METHOD FOR PRODUCING COMPOSITION FOR REGENERATING CARTILAGE USING LYOPHILIZATION HYALINE CARTILAGE POWDER, COMPOSITION FOR REGENERATING CARTILAGE PRODUCED USING THE SAME, METHOD FOR PRODUCING SCAFFOLD FOR REGENERATING PATIENT-CUSTOMIZED CARTILAGE USING COMPOSITION FOR REGENERATING CARTILAGE, AND SCAFFOLD FOR REGENERATING PATIENT-CUSTOMIZED CARTILAGE

Resumen de: US2025366997A1

The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.

Bone insert augment and offset device

Resumen de: US2025366893A1

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and/or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and/or have bone ingrowth surface features that create a strong bond with the bone.

FUNCTIONAL GRADIENT LATTICE IN ORTHOPEDIC FIXATION IMPLANT

Resumen de: US2025366894A1

A three-dimensional (“3D”) printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.

PHOTODETECTORS FOR MEASURING REAL-TIME OPTICAL IRRADIANCE

Nº publicación: US2025369798A1 04/12/2025

Solicitante:

REGENTS OF THE UNIV OF MINNESOTA [US]
Regents of the University of Minnesota

Resumen de: US2025369798A1

A skin-wearable photodetector module includes an array with a plurality of photodetectors and a plurality of optical filters, and each photodetector is configured to receive an optical input from an optical filter having a central wavelength in a wavelength range of about 100 nm to about 1000 nm. Each photodetector includes a substrate with a first major surface having an electrode thereon, and a second major surface overlying an optical filter, an anode within an interior region of the electrode, an active layer including a. ternary mixture of an electron donor, an electron acceptor, and at least one charge carrier trap material, and a cathode that contacts the active layer.