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SYSTEMS AND METHODS FOR PRIORITIZING DIGITAL THERAPEUTIC CONTENT BASED ON COMPREHENSIVE ASSESSMENT TEST RESULTS

Resumen de: WO2026183009A1

Presented herein are systems and methods for prioritizing digital therapeutic content based on comprehensive assessment test results. A computing system can maintain a patient profile for each patient of a plurality of patients including results data corresponding to a comprehensive assessment test testing across a plurality of domains. The computing system can maintain a plurality of task objects, each task object corresponding to at least one of the plurality of domains. The computing system can assign a rank to each domain based on the respective domain-specific result data. The computing system can generate a treatment plan including one or more task objects, wherein each task object is selected or arranged based on whether the task object corresponds to a group of domains. The computing system can provide data corresponding to the one or more task objects in accordance with the treatment plan.

APPARATUS AND METHODS FOR NEURAL STIMULATION USING POLYNOMIAL DISTORTION ALGORITHM

Resumen de: WO2026183411A1

Exemplary embodiments of the present disclosure include apparatus, methods and systems for therapeutic neuromodulation of neurons and circuits utilizing a polynomial distortion algorithm (PDA). Exemplary embodiments provide for selective activation of specific model neurons by PDA tuning of the stimulating waveform to the intrinsic biophysical properties of the neuron. Furthermore, exemplary embodiments provide energy optimization of the waveform that can minimize off-target effects. Selective activation of specific model neurons can be achieved by PDA tuning of the stimulating waveform to the intrinsic biophysical properties of the neuron. Furthermore, energy optimization of the waveform can minimize off-target effects. Apparatus and methods utilizing a polynomial distortion algorithm to stimulate neurons with different channel activation properties, channel conductance properties, and diameters are provided.

Dissolvable Pore Reinforcement For Surface Overmolding

Resumen de: US20260256590A1

0000 A method of manufacturing an implant including additively manufacturing the implant from a first material such that the implant defines a plurality of pores. Then inserting a filler material into the pores after the implant has been manufactured. Next, overmolding the implant with a second material after the filler material has been inserted the pores, and then dissolving the filler material from the pores prior to deployment of the implant.

A MICROFLUIDIC DEVICE FOR MODELLING VASCULATURE ACTIVITY AND A METHOD OF FORMING THEREOF

Resumen de: WO2026178602A1

A patient-specific microfluidic device for modelling thrombotic response and method of making thereof. The device includes a flow channel having a geometry that substantially corresponds to a patient's vascular geometry in a region of interest, said geometry derived from one or more clinical images associated with the patient. The device includes endothelial cells lining at least a portion of the flow channel, and at least one portion of laser-induced injury corresponding to an identified injury site of the patient or a desired injury site for modelling.

COMPOSITIONS AND METHODS FOR TREATING KIDNEY DISEASES IN PETS

Resumen de: WO2026181069A1

Methods of culturing renal cells of pets are provided. Also provided are methods of producing spheroids and organoids from pet renal cells and uses thereof in regenerating renal function.

SYSTEMS AND METHODS FOR OPTIMIZED RETINAL IMAGE CAPTURE USING DUAL-STAGE AI-BASED QUALITY ASSESSMENT

Resumen de: WO2026183110A1

Disclosed in an integrated retinal imaging system designed to enable high-quality, diagnostic image capture with minimal operator intervention. The system can implement a dual-stage Holistic Quality Assessor (HQA), with HQA-1 performing real-time, holistic quality assessments on infrared or near infrared image frames to detect optimal capture conditions, and HQA-2 verifying the diagnostic adequacy of a captured color image. Both HQA-1 and HQA-2 can leverage machine learning or deep-learning models executed on a local hardware accelerator and are configured to provide low-latency and accurate evaluations. By combining dual-stage quality assessment with real-time capture optimization, the system can enable reliable, diagnostic-quality image capture across various clinical settings and user experience levels.

METHOD FOR PREPARING CERAMIC SLURRY FOR PHOTOCURABLE 3D PRINTING

Resumen de: WO2026182384A1

The present invention relates to a method for preparing a ceramic slurry for photocurable 3D printing and, more specifically, to a method for preparing a ceramic slurry for photocurable 3D printing, in which ceramic or glass-ceramic powder is used such that a dental prosthesis can exhibit esthetics similar to those of a natural tooth and, furthermore, a non-reactive diluent is included so that a low-viscosity slurry can be prepared even while containing a high amount of the ceramic or glass-ceramic powder, wherein the slurry thus prepared is easily moldable using 3D printing, can be manufactured into a high-quality three-dimensional sculpture during 3D printing, has high precipitation stability during storage, and can maintain the viscosity even during a 3D-printing process.

BIOINK AND SCAFFOLD FOR CORNEAL TISSUE REGENERATION AND METHOD OF MANUFACTURE

Resumen de: WO2026180764A1

The invention relates to a bioink for 3D printing of a scaffold (1) suitable for corneal tissue regeneration, composed of sodium alginate, aldehyde hyaluronic acid, N,O-carboxymethyl chitosan and collagen I, where the collagen I undergoes a preliminary neutralisation process using sodium hydroxide. The present invention also describes a method for the 3D printing of a scaffold (1) suitable for corneal tissue regeneration and a method for sterilising same using ethylene oxide (EtO).

MATERIAL EXTRUSION 3D PRINTING PROCESS FOR BIODEGRADABLE MAGNESIUM ALLOY

Resumen de: WO2026182531A1

The present invention provides a 3D printing process for a magnesium alloy, comprising: a step of manufacturing an extrusion material comprising a magnesium alloy powder and a binder; a step of extruding the extrusion material so as to form a molded body; and a sintering step of sintering the molded body in a hydrogen-containing inert gas atmosphere. According to the process of the present invention, carbon by-products can be minimized during sintering and good interparticle bonding can be achieved, and thus a customized 3D-printed body having excellent physical properties can be provided.

3D Bioprinted Model for Quantifying Neurite Outgrowth

Resumen de: US20260258350A1

A three-dimensional (3D) bioprinted model of a forebrain cortex is designed to quantify neurite outgrowth across a hydrogel bridge. The 3D bioprinted model includes two cell-laden compartments formed using a first hydrogel matrix, separated by a hydrogel bridge formed from a second, stiffer hydrogel matrix. The model may fit within standard 96-well plate formats, enabling medium-throughput screening applications. The model was validated using Alzheimer's disease forebrain cortical populations, demonstrating significant reductions in neurite outgrowth from Alzheimer's disease populations compared to controls.

A NOVEL METHOD TO ALTER THE PROTEOME OF A DISEASED HEART BY INJECTION OF ECM PARTICLES PRODUCED FROM DECELLULARIZED 3D MICROTISSUES OF HUMAN MESENCHYMAL STEM CELLS

Resumen de: WO2026183490A1

This disclosure describes a method for altering the proteome of a diseased heart, organ or tissue by contacting it with extracellular matrix (ECM) particles derived from decellularized 3D microtissues. In an example, the process involves restoring the normal ratio of collagen levels, modulating immune responses, improving mitochondrial function, and/or mitigating the effects of TGF-Beta, a growth factor associated with fibrosis. The ECM particles can be produced from human mesenchymal stem cells and retain bioactive components and structural properties of native tissue. Additionally, the disclosure outlines a composition for treating a diseased organ using these ECM particles, which are treated to enhance crosslinking, stability, injectability, and compatibility with patients.

SYSTEM AND METHOD FOR OPTIMAL MAGNETIC RESONANCE EXAM WITH RETROSPECTIVE REFORMATTING WORKFLOW THAT LEVERAGES INTEGRATED GUIDELINES

Resumen de: US20260259290A1

A method includes receiving at a protocol optimizer an electronic medical record for the subject, wherein the electronic medical record includes a scan order for scanning a region of interest of the subject for a patient specific clinical indication with a magnetic resonance scanner. The method also includes utilizing the protocol optimizer to automatically access one or more initial protocols specific to the patient specific clinical indication from radiology guidelines and/or a protocol library. The method further includes generating with the protocol optimizer one or more optimized protocols from the one or more initial protocols for performing an acquisition including a three-dimensional (3D) acquisition of 3D image data of the region of interest of the subject, wherein the protocol optimizer is configured to reduce a number of scans for each contrast that is required by the patient specific clinical indication over the region of interest along multiple planes.

PREMATURE HEARTBEAT ANALYSIS

Resumen de: US20260256403A1

Systems and methods include approaches for calculating a relative timing value for respective beats associated with a rhythm classification, determining that respective relative timing values for a first set of the beats are within a first range of prematureness, and displaying time series cardiac data of the first set of the beats in a first window of a user interface.

SYSTEMS AND METHOD FOR LINKING COSMETIC LIP COLORS TO EMOTIONS

Resumen de: US20260256395A1

A computer system receives sensor data from sensors configured to measure a user's neurophysiological response to verbal stimuli in the form of an identified emotion presented to the user and visual stimuli in the form of cosmetic colors presented to the user via a user interface; displays representations of available cosmetic colors to the user; receives user input indicating selection of a candidate cosmetic color from among the available cosmetic colors displayed; displays to the user an avatar wearing a virtual cosmetic of the candidate cosmetic color; receives user rating data responsive to display of the avatar wearing the virtual cosmetic of the candidate cosmetic color; and determines whether the candidate cosmetic color is associated with the identified emotion based on the user rating data and the sensor data. The sensors may include brain activity, electrodermal activity, eye tracking, and/or heart activity sensors.

SYSTEMS, DEVICES, AND METHODS FOR DETERMINING FETAL WELLNESS USING FETAL ECG AND FETAL OXIMETRY INFORMATION

Resumen de: WO2026183135A1

Fetal electrocardiogram (ECG) information and fetal oximetry information may be used, in combination, to determine one or more indicators, or predictions, of fetal wellness, blood oxygen saturation, and/or heartrate. At times, the fetal ECG and fetal oximetry information may be input into a fetal health model to determine and/or predict fetal wellness and/or trends in fetal wellness over time. In some embodiments, the fetal ECG and fetal oximetry information may be obtained via a single, combined, device configured to obtain and/or measure the fetal ECG and fetal oximetry information via direct contact with a fetus. Additionally, or alternatively, fetal oximetry information may be measured via a transabdominal fetal oximetry sensor and/or transcervical device configured to be positioned in the vagina and contact the cervix.

INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD, AND PROGRAM

Resumen de: WO2026182227A1

Provided is a technology enabling reduction of administrator burden and enabling timely response for prevention of heat stroke. 　A WBGT value acquisition unit 51 acquires a WBGT value from a WBGT measurement device 4. A worker site information acquisition unit 52 acquires, from an administrator terminal 2, elicited information such as physical condition when reporting to work, medical history, work intensity, clothing, and heat acclimatization, and acquires, from a portable worker terminal 3, vital information such as heart rate, blood oxygen saturation, and activity level. A correction value calculation unit 53 calculates a correction value through AI analysis. An individual worker reference value calculation unit 54 calculates a corrected WBGT reference value for each worker by using the correction value to perform an operation on a WBGT reference value. A heat stroke risk value calculation unit 55 calculates a heat stroke risk value from the difference between the WBGT value and the corrected WBGT reference value.

IMPROVED EVALUATION OF MEDICAL DEVICE RELATED DATA

Resumen de: WO2026180968A1

A method including executing an automatic evaluation of data residing on a computing system pertaining to a specific medical device. The method comprising obtaining access to a computing system, and via the computing system, obtaining access to data based on medical device settings and/or phenomena recorded in association with the medical device and executing an automated evaluation of the accessed data and gauging efficacy of the medical device based on results of the automated evaluation.

GEOGRAPHICALLY DISTRIBUTED DENTAL CARE MANAGEMENT SYSTEM FOR TREATMENT COORDINATION, TRANSPARENT ALIGNER FABRICATION, AND SPECIALIST COLLABORATION

Resumen de: WO2026181074A1

A system and method for managing dental treatment across geographically distributed clinics utilize a digital imaging module to capture intra-oral digital scans. A treatment planning module formulates a dental treatment plan validated by a remote orthodontic specialist. A patient management module orchestrates a competitive tender process to select an executing general dentist from a plurality of candidates based on weighted criteria comprising cost, proximity, and performance ratings. A manufacturing module interfaces with distributed laboratories for aligner fabrication. In some embodiments, the system incorporates a blockchain network with smart contracts for milestone-based financial execution and an artificial intelligence module for predictive treatment optimization. A real-time interactive aligner device comprising electromechanical micro-actuators enables remote geometric adjustments of the aligner in response to specialist instructions. A communication interface facilitates continuous feedback and oversight between patients, specialists, and selected providers, ensuring unified clinical quality and operational efficiency across the distributed network.

DIAGNOSING AND TREATMENT UVEAL MELANOMA

Resumen de: WO2026183498A1

The present disclosure relates to methods for diagnosing and treating uveal melanoma.

MACHINE LEARNING MODELS TO PREDICT GLAUCOMATOUS DAMAGE

Resumen de: WO2026183445A1

Presented herein are systems and methods of determining likelihoods of neurodegenerative vision loss in eyes due to glaucoma. A computing system may receive, for a subject at risk of neurodegenerative vision loss in an eye due to glaucoma, a dataset. The dataset includes a first biomedical image of the eye associated with the subject at a first intraocular pressure (IOP), a second biomedical image of the eye associated with the subject at a second IOP, and a plurality of characteristics associated with the subject. The computing system may apply a machine learning (ML) architecture on the dataset. The computing system may determine, based on applying the dataset to the ML architecture, a predicted metric in the eye of the subject. The computing system may generate, using the predicted metric, a score indicating a likelihood of neurodegenerative vision loss in the eye due to glaucoma.

MODEL-RECEIVING BODY FOR FASTENING A JAW MODEL

Resumen de: WO2026180184A1

The invention relates to a model-receiving body (1) for fastening a jaw model (2) in an articulator (3), wherein: the model-receiving body (1) has a first side (4) for fastening the jaw model (2) and a second side (5) opposite the first side (4); the model-receiving body (1) has a plurality of bearing bars (6) for the jaw model (2) and a fastening device (7) for magnetically fastening the model-receiving body (1) to the articulator (3) or to an adapter plate (8); open spaces (9), which are open towards the first side, are formed between the bearing bars (6) in the model-receiving body (1), and the bearing bars (6) have bearing surfaces (10) for supporting the jaw model (2) in a first direction (11) pointing away from the second side (5); the model-receiving body (2) has at least two, preferably three, position-securing pins (12), which are arranged at a distance from one another and project beyond the bearing surfaces (10) in the first direction (11), for aligning the jaw model (2) in two directions (13, 14), which are orthogonal relative to the first direction (11) and also relative to one another.

THYMIC CELL COMPOSITIONS AND METHODS OF MAKING

Resumen de: US20260256842A1

0000 The present disclosure provides thymic cells, thymic organoids, and animal models comprising such thymic cells and thymic organoids. It also provides methods for inducing differentiation of pluripotent stem cells into definitive endoderm (DE), anterior foregut endoderm (AFE), ventral pharyngeal endoderm (VPE), thymic epithelial progenitor (TEP) cells, thymic epithelial cells (TECs) and thymic organoids in vitro and in vivo.

TABLET DISPENSER

Resumen de: US20260256654A1

0000 The present invention is directed to a tablet dispenser. The tablet dispenser includes: a discharge part sealing unit positioned beneath a plurality of tablet discharge devices each including a discharge part for discharging stored tablets, and provided with a plurality of openings; and a tablet collection module positioned beneath the discharge part sealing unit. When the discharge part sealing unit is moved in a first planar direction, it blocks the discharge parts to spatially separate the plurality of discharge parts from the tablet collection module. When the discharge part sealing unit is moved in a second planar direction opposite the first planar direction, it positions the openings in the same lines as the corresponding discharge parts to allow the plurality of discharge parts to spatially communicate with the tablet collection module.

Anisotropic Materials in Medical Devices

Resumen de: US20260256592A1

0000 A system and method for improving upon an ability of a surgeon to repair traumatic bone injury using new materials, components, and structures. A structure may be used as an implant or a component of an external fixator for a fractured long bone with that structure having anisotropic and viscoelastic properties, such as through additive manufacturing techniques.

FUNCTIONALIZED RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Nº publicación: US20260258096A1 03/09/2026

Solicitante:

EVONIK OPERATIONS GMBH [DE]
Evonik Operations GmbH

Resumen de: US20260258096A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one non-terminal alkene group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.