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脑胶质瘤双腔放化疗一体化治疗囊

Resumen de: CN121695407A

脑胶质瘤双腔放化疗一体化治疗囊，本发明是要解决现有放射性籽源或化疗载体无法兼顾放疗与化疗、剂量调控困难、药物分布不均等问题。本发明脑胶质瘤双腔放化疗一体化治疗囊由放疗管道与化疗管道组成一体化治疗囊，一体化治疗囊整体呈螺旋管体，放疗管道位于内圈，化疗管道位于外圈，放疗管道为封闭腔体，封闭腔体内装有液体放射源，从化疗管道的头端释放化疗药物，从化疗管道的尾端注入化疗药物，一体化治疗囊的表面涂覆复合抑菌层。本发明一体化治疗囊将放射性药物与化学药物分别置于内外双腔中，通过双通道同步作用，实现放疗与化疗的协同治疗，通过调节螺距及管壁厚度，实现放射性药物与化疗药物的长时程低剂量释放，减少毒副作用。

UNIVERSAL TISSUE FABRICATION TECHNIQUES FOR SELF-ASSEMBLED ORGAN PRODUCTION AND REGENERATIVE MEDICINE APPLICATIONS

Resumen de: WO2026060262A1

Methods and systems are described for a high-level approach to organ generation by self-assembly using bioprinting, overcoming longstanding challenges in replicating the intricate architecture and function of complex organs. In some embodiments, these methods are used to produce lung tissues and microtissues, demonstrating how mini-lung constructs can be produced on a small scale through specialized processes and media. In such embodiments, methods and systems for generating bioprinted lung tissues and microtissues are provided, as are tissues made by such methods. The tissues find use in implantation, drug discovery, personalized medicine, and other applications. Methods for the large-scale manufacturing of lung epithelial stem cells are also provided.

3D PRINTED SCAFFOLD IMPLANT AND A METHOD FOR MANDIBULAR RECONSTRUCTION

Resumen de: WO2026055724A1

The present invention relates to a 3D scaffold implant system for mandibular reconstruction, featuring a scaffold structure that includes at least four scaffold segments strategically positioned within the implant, the segments ensuring precise placement within a subject's jawbone and facilitate optimal integration with a surrounding bone tissue; a fluid delivery tube system integrated into each of the scaffold segments to administer a growth factor(s) and an antibiotic directly into the scaffold implant; a pump that facilitates controlled delivery of the growth factors into the scaffold segments; at least three fixation that provide stability to the implant and micro-motors that enable precise alignment of the scaffold implant to conform seamlessly to the natural curvature of the jawbone.

SCAFFOLD COMPOSITE, AND PREPARATION METHOD AND USE THEREOF

Resumen de: US20260077107A1

A scaffold composite, and a preparation method and use thereof are provided. The preparation method includes: mixing a graphene oxide (GO) dispersion and a polylactic acid (PLA) dispersion, and subjecting a resulting mixed solution to curing and melt extrusion in sequence to obtain a 3-dimensional (3D)-printable GO/PLA composite wire; subjecting the 3D-printable GO/PLA composite wire to 3D printing to obtain a scaffold; and annealing the scaffold to obtain the scaffold composite.

SYSTEM AND METHOD FOR COLORING A DENTAL PROSTHESIS

Resumen de: US20260076787A1

Disclosed are example embodiments of methods and systems for automatically coloring a dental prosthesis. One of the systems includes: a memory configured to store a computer-aided manufacturing (CAM) file of the dental prosthesis; a holding apparatus for securing the dental prosthesis; one or more outlets for dispensing coloring fluid; an coloring fluid controller configured to control the one or more outlets to dispense coloring fluid at a preset size and frequency based at least on the CAM file; and a motion controller configured to move the holding apparatus or the one or more outlets based at least on the CAM file.

DEVICE FOR PRODUCING A MOLDED PART OF A DENTAL SPLINT

Resumen de: US20260076777A1

A device for producing a molded part of a dental splint includes a base element, a retaining plate, and at least one receiving element. The at least one receiving element is arranged releasably on an upper side of the retaining plate. The at least one receiving element is designed to receive a tooth template. The at least one receiving element is fixable on the retaining plate in a plurality of positions and/or orientations. Also disclosed is an apparatus for producing a dental splint by such a device, and to a method for producing a dental splint, in particular using the apparatus.

A TEAT PRODUCT AND A METHOD FOR PRODUCING A TEAT PRODUCT

Resumen de: US20260076876A1

A teat product having a base portion and a nipple portion extending from the base portion, the teat product having a pliable region, wherein said pliable region of the teat product is configured to be deformable in shape in response to force applied by a mouth of a feeding infant.

METHOD AND SYSTEM FOR PROCESSING PRINTED PART

Resumen de: WO2026057069A1

The present application provides a method for processing a printed part formed by additive manufacturing. The method comprises: providing a printed part having an identifier; identifying the identifier on the printed part, and on the basis of at least the identified identifier and/or database information, transmitting a target signal or generating a target indication; and in response to the target signal or the target indication, a target prompting device among a plurality of prompting devices issuing a prompt, wherein the target prompting device is associated with a storage device for storing the printed part.

ORTHOTIC AND PROSTHETIC DEVICE AND MANUFACTURING SYSTEM AND METHOD

Resumen de: US20260076812A1

A prosthetic device includes a socket, fasteners, and a pylon. The socket defines a cavity configured to receive a residual limb of a user. The socket includes a base defining multiple blind-holes. Each of the fasteners are configured to be received within a corresponding one of the blind-holes. The fasteners each include internal threads. The pylon includes through-holes that are aligned with a corresponding one of the blind-holes. The pylon is configured to be directly coupled with the base of the socket through externally threaded fasteners that extend through the through-holes and threadingly couple with the internal threads of the plurality of fasteners.

DENTAL ATTACHMENT POSITIONING DEVICES AND METHODS OF MAKING SAME

Resumen de: US20260076778A1

A dental attachment positioning device may include a plurality of registration elements. The registration elements may include a tooth registration surface configured to mate with one or more teeth of a patient and a retention support for holding the registration element to one or more teeth of a patient. An attachment support may extend from and be releasably coupled to one or more dental attachments. A coupling may be located between two adjacent registration elements. The coupling may include a force concentration structure. The force concentration structure may include a notch or channel configured to facilitate a breakage between the two adjacent registration elements.

BRAKE ASSEMBLY, STEERING ARM ASSEMBLY AND RACING WHEELCHAIR

Resumen de: US20260077746A1

A brake assembly for a personal mobility vehicle, in form of a racing wheelchair, comprises a brake lever for actuating a brake cable, wherein the brake lever is a 3D printed glass filled nylon unit, in particular with up to 30% glass filled nylon. A steering arm assembly comprises a steering arm with the brake assembly integrated into the steering arm A racing wheelchair with one front wheel is attached to a wheelchair frame via a fork, with two drive wheels as well as a steering cage mounted on the rear of the wheelchair frame. The brake assembly and/or the steering arm assembly are mounted to the wheelchair frame.

HYDROGELS FOR 3D PRINTING HAVING HIGH RESOLUTION

Resumen de: US20260078274A1

In one aspect, build materials for use with a three-dimensional (3D) printing system are described herein. In some embodiments, a build material described herein comprises an acrylate component, a photoinitiator component, a non-curable absorber component, and water. The photoinitiator component of the build material is operable to initiate curing of the acrylate component and/or other curable materials that may optionally be present when the photoinitiator is exposed to incident curing radiation having a Gaussian distribution of wavelengths and a peak wavelength λ. The build material has a penetration depth (Dp) and a critical energy (Ec) at the wavelength λ. In some embodiments, the Dp is greater than 200 μm and less than 300 μm, and the Ec is 3-12 mJ/cm2. In other embodiments, the Dp is greater than 10 μm and less than 50 μm, and the Ec is 5-40 mJ/cm2.

PHARMACEUTICAL DOSAGE FORMS AND PREPARATION METHODS THEREOF

Resumen de: AU2024340886A1

Provided herein are a pharmaceutical dosage form and a method for preparing thereof, such as a pharmaceutical dosage form prepared by a three-dimensional printing method. Pharmaceutical dosage forms loaded with liquid or semi-solid materials, and pharmaceutical dosage forms loaded with solid material are both provided.

MEDICAL TISSUE WRAP

Resumen de: US20260076835A1

A medical tissue wrap, for an internal anatomical structure of a mammal is formed by a coiled wall having a circumferential inner end portion and a circumferential outer end portion extending around and overlapping the circumferential inner end portion. The wall thereby defines a longitudinal through-hole for accommodating a portion of the anatomical structure. The circumferential outer end portion is radially spaced-apart from the circumferential inner end portion by a discontinuous spacing in the circumferential direction. The tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

TIBIAL IMPLANT

Resumen de: EP4711135A1

Die Erfindung betrifft ein Tibia-Implantat (2) für Gelenkersatz, welches aus Metalllegierung in einem additiven Fertigungsverfahren, insbesondere durch metallischen 3D-Druck, hergestellt ist, mit einem Plateauabschnitt (4) und mit einem auf der tibiazugewandten Seite (8) des Plateauabschnitts (4) vorspringenden und sich davon in einer axialen Richtung (10) wegerstreckenden zapfen- oder kielförmigen Ankerabschnitt (6), welcher in einen hierfür vorbereiteten Kanal in einem Tibiaknochen in der axialen Richtung (10) einsetzbar ist; erfindungsgemäß wird vorgeschlagen, dass der Plateauabschnitt (4) auf seiner tibiazugewandten und mit Tibiaknochengewebe in Kontakt gelangenden Seite (8) eine dreidimensional poröse offenporige Oberflächenstruktur (14) mit in der axialen Richtung (10) hintergreifbaren Brücken, Stegen oder Wandbereichen aufweist, wobei die dreidimensional poröse offenporige Oberflächenstruktur (14) eine erste Rauigkeit aufweist, und dass der zapfen- oder kielförmige Ankerabschnitt (6) anschließend an den Plateauabschnitt (4) in einem ersten axialen Ankerbereich (20) umfangsseitig eine in einer radialen Richtung (12) hinterschnittfreie, das heißt von hintergreifbaren Brücken und brückenbildenden Stegen freie Oberflächenstruktur (28) mit einer zweiten Rauigkeit aufweist, die geringer ist als die erste Rauigkeit, unddass der zapfen- oder kielförmige Ankerabschnitt (6) in der axialen Richtung (10) anschließend an den ersten axialen Ankerbereich (20) einen

PROCESS FOR PRODUCING A ZIRCONIA DENTAL ARTICLE

Resumen de: CN121285362A

The invention relates to a method for producing a dental zirconia article, comprising the following steps: processing a radiation-curable zirconia sol A as a construction material in a laminate manufacturing process comprising a radiation curing step to obtain a zirconia gel article, the zirconia gel article has the shape of a dental article with an outer surface and an inner surface; applying a radiation curable zirconia sol Bx on at least a portion of the outer surface of the zirconia gel article; radiation curing the radiation curable zirconia sol Bx of step (b); converting the zirconia gel article into a zirconia aerogel article, the radiation-curable zirconia sol A being the same as or different from the radiation-curable zirconia sol Bx in terms of chemical composition and/or physical properties. The invention also relates to a dental ceramic zirconia article obtainable by a process according to any of the preceding claims.

DOSE DIVIDER

Resumen de: CN121443343A

A dose dispenser for releasable attachment to a plunger rod of a syringe includes a first arm and a second arm. The front portion of the first arm and the front portion of the second arm form a channel therebetween for receiving a plunger rod. A resilient hinge pivotably couples the first arm and the second arm such that the dose dispenser is reversibly movable between a first configuration and a second configuration. When the dose dispenser is in the second configuration, the dose dispenser is configured to receive the plunger rod in the channel through an opening formed between the anterior portion of the first arm and the anterior portion of the second arm. The channel has a shape configured to receive a particular external shape of the plunger rod. The front portion of the first arm and the front portion of the second arm are closer when the dose dispenser is in the first configuration than when the dose dispenser is in the second configuration.

SCAFFOLD WITH STEM CELLS

Resumen de: EP4710957A1

Scaffold with stem cells comprises 60 per cent biomaterial, consisting of 75 per cent Silicone by weight, Poli Glycolic Acid at 1.87 per cent, Xanthan Gum at 1.25 per cent, NaCl at 3.75 per cent, Agar at 3.75 per cent, Carbon Fullerene C60 at 4.38 per cent and water at 2.5 per cent. All reacted with 7.5 per cent Silicone catalyst and a 40 per cent predominantly cellular materials composed of ASC, i.e. mesenchymal cells of adipose origin, 50 per cent, Hyaluronic Acid at 30 per cent and TGF-beta, i.e. transforming growth factor beta, at 20 per cent.

一种硅胶阻鼾器制造系统及方法

Resumen de: CN121671003A

本发明涉及一种硅胶阻鼾器制造方法，属于医疗产品技术领域。该方法包括以下步骤：S1、数据获取与建模；S2、配准：将三维牙颌模型与头颅侧位片配准，实现牙颌模型与气道软组织的空间对齐；S3、测量分析：测量气道间隙、舌体形态及颌骨位置参数；S4、个性化矫正：根据测量结果自动设定下颌骨的前伸量与垂直打开量，依据WALA嵴与FA点设计牙弓扩弓宽度，设计舌诱导屏斜面角度以引导舌体向前向上移动；S5、制造。本发明突破传统阻鼾器仅能单一前移下颌的局限，通过协同调控下颌骨三维位姿、牙弓宽度及舌体姿态，实现对气道长度、宽度和高度的立体化综合扩展，有效增大气道容积，改善通气效率，显著提升对OSAHS的矫治效果。

一种用于治疗口呼吸的个性化3D打印水凝胶贴片及其制备方法

Resumen de: CN121668051A

本发明公开了一种用于治疗口呼吸的个性化3D打印水凝胶贴片及其制备方法，涉及3D打印水凝胶贴制备技术领域，包括获取使用者唇部区域的三维表面形貌数据，并基于该数据构建个性化水凝胶贴片的数字模型；根据数字模型设计具有唇周贴合轮廓的三维结构文件；配制包含明胶甲基丙烯酰化、多巴胺甲基丙烯酰胺、丙烯酰胺、聚乙二醇二丙烯酸酯、光引发剂及护肤型功能性添加剂的预聚物溶液；将预聚物溶液注入光固化3D打印设备，并调用三维结构文件进行逐层曝光打印，形成湿态水凝胶贴片；将湿态水凝胶贴片置于缓冲溶液中清洗，以去除未反应组分；对清洗后的水凝胶贴片进行后固化处理，使交联网络充分形成，获得具备适中黏附力与高韧性的成品贴片。

一种用于3D打印的高内相双峰乳液及其制备方法和应用

Resumen de: CN121673466A

本发明涉及一种用于3D打印的高内相双峰乳液及其制备方法和应用，所述制备方法包括如下步骤：将第一高内相乳液和第二高内相乳液进行剪切搅拌混合，得到所述用于3D打印的高内相双峰乳液；所述第一高内相乳液的众数粒径大于第二高内相乳液的众数粒径。本发明提供的用于3D打印的高内相双峰乳液具有自稳定性，进行3D打印的结构稳定好，精度高，不易出现结构坍塌、变形、分层和脱落等问题。

一种抑菌水凝胶人造皮肤及其制备方法

Resumen de: CN121668395A

本申请提供了提供了一种抑菌水凝胶人造皮肤及其制备方法，属于3D打印生物材料技术领域，按重量份数计，包括以下原料制备得到：六水合氯化铝1～3份、水30～45份、接枝改性壳聚糖15～22份、丙烯酰胺8～15份、N,N'‑亚甲基双丙烯酰胺0.2～0.8份、光引发剂0.5～1.5份、季铵化壳聚糖6～12份和纳米羟基磷灰石4～8份。其中，接枝改性壳聚糖包括以下原料制备而成：壳聚糖5～10份，浓度2%乙酸溶液80～120份、甲基丙烯酸缩水甘油酯0.8～2.5份和偶氮二异丁腈0.05～0.2份。本申请通过采用以接枝改性壳聚糖为核心的配方，形成多尺度交联和个性化3D打印的协同设计，实现水凝胶的高力学强度、广谱长效抑菌、精准形态适配与优异生物相容性，满足临床复杂创面修复需求。

一种陶瓷内窥镜抓钳钳头及其一体化成型方法

Resumen de: CN121673045A

本发明公开了一种陶瓷内窥镜抓钳钳头的一体化成型方法。方法以氧化锆模型墨水与水溶性支撑墨水为原料，通过材料喷射成型逐层构建含上钳口、下钳口、旋转轴、连接管及螺纹鞘头的整体生坯；在齿形咬合区、镂空键槽及活动间隙按特定比例混合填充支撑，并在每2‑5层后采用螺旋滚刀在线铣削，保证尺寸精度。生坯经水洗、干燥、1550℃烧结后，制得致密度≥99.9%、Ra 3‑4μm、抗弯强度≥800MPa的陶瓷钳头，无需后续机加工或铆接。产品闭合宽度≤10mm，总长≤50mm，鳄鱼形弧面与32齿R0.1mm倒角协同镂空键槽、椭圆排液孔，实现轻量化、低损伤、高夹持力，可顺利通过φ2.0mm内镜通道，满足一次性使用需求，解决不锈钢钳头加工难、易过敏、易疲劳及成本高的问题。

电场辅助3D打印制备含电气石颗粒的同轴骨支架的方法

Resumen de: CN121668399A

本发明公开了一种电场辅助3D打印制备含电气石颗粒的同轴骨支架的方法，包括：步骤1、制备外壳浆料和内芯浆料；步骤2、搭建电场辅助的同轴3D打印设备；步骤3、打印同轴骨支架。本发明将同轴3D打印技术与静电场技术相结合，通过同轴加料口和环形电极的设计，制备了具有粘度梯度的同轴支架，内芯为高粘度浆料容易凝固成型，提供良好的力学支撑；外壳为含电气石颗粒的低粘度浆料，能在环形电极形成的静电场的作用下使电气石颗粒在支架表面定向排列。

一种模拟天然软骨四层结构的组织工程关节软骨及其原位3D打印方法

Nº publicación: CN121668406A 17/03/2026

Solicitante:

中国人民解放军陆军第九五八医院

Resumen de: CN121668406A

本发明涉及一种模拟天然软骨四层结构的组织工程关节软骨及其原位3D打印方法，通过精准的分层建模与层特异性生物墨水，复刻天然软骨“表层‑移行层‑辐射层‑钙化层”的结构与成分特征，依托优化的原位3D打印工艺，在关节腔内直接构建与缺损区解剖匹配、与天然软骨力学及生理功能一致的组织工程软骨。另外，本发明减少了BMSCs体外诱导分化步骤，降低细胞突变风险，同时提升修复组织与宿主软骨的长期整合性，解决了临床修复长期有效性不足的问题。