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165
resultados
Última actualización
02/10/2025 [07:15:00]
Resultados 50 a 75 de 165
Resumen de: CN120678985A
本发明属于生物医用材料技术领域，具体涉及一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用。本发明提供了一种葡萄糖响应性DLP 3D打印胶原蛋白生物墨水；所述生物墨水在pH 7的生理条件下可制备具有良好的机械性能、保真度和抗降解能力的水凝胶；且该凝胶可在高血糖环境下进行响应性释放；释放的姜黄素可以清除细胞内ROS，调控巨噬细胞炎症因子表达，发挥抗氧化抗炎功效，并且凝胶材料还能够促进细胞的增殖、黏附、迁移，具有良好的生物相容性和生物活性；在为糖尿病创面治疗提供了兼具智能释药、力学适配与主动促愈功能的个性化解决方案。
Resumen de: CN119968177A
The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.
Resumen de: CN120661733A
本发明公开了一种3D打印构建骨肿瘤修复的压电骨支架的制备方法，属于生物医用材料领域。所述方法通过3D打印构建骨肿瘤治疗修复的压电骨支架材料，具体包括以下步骤：均匀混合固定体积比的钛酸钡(BTO)和羟基磷灰石(HA)，通过光固化树脂，打印具有特定孔隙结构的生胚，随后经过脱脂、烧结、极化和后处理，制得BTO/HA压电复合骨支架。本发明制备得到的压电复合骨支架具有与骨缺损部位高度匹配的精确形状，同时可通过压电效应催化产生活性氧自由基，实现残留骨肿瘤细胞的高效原位灭活，将骨肿瘤治疗(压电抗肿瘤)和骨缺损修复(HA促骨化)两大功能集成于一体，提升治疗修复效果，改善患者的生活质量。
Resumen de: CN120661738A
本发明提供了光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用，属于生物医药技术领域。本发明提供的材料能够在不同环境条件下持续地释放H₂O₂。尤其是在模拟体内环境中，GHDP水凝胶在较长时间内保持稳定的H₂O₂释放，从而不断激活血管生成相关的信号通路，在颅骨缺损修复过程中，能够通过调控H₂O₂水平，促进新生血管形成和成骨分化，为利用氧化还原信号调控来促进组织再生提供了新的策略与思路。
Resumen de: CN120665428A
本发明涉及一种光固化3D打印含碳导电多孔材料及其制备方法及应用。该方法基于巯基‑烯点击化学与聚合诱导相分离原理，通过将含巯基低聚物、含烯基低聚物、导电碳材料及致孔剂复配为低粘度墨水，通过对墨水聚合反应动力学和流变性质研究，结合光固化3D打印技术一步成型多尺度多孔结构。所述致孔剂兼具溶剂功能，降低墨水粘度并诱导微观孔隙生成，与宏观模型设计结合，形成多级孔隙网络。所得材料在智能传感、电磁屏蔽及水处理等领域展现出潜在应用价值。
Resumen de: CN120661739A
本发明公开了一种基于3D打印的可降解鼻大翼软骨支架及其制备方法，支架由PLGA以及纳米羟基磷灰石复合基体、载药微球及梯度多孔仿生结构组成，表面覆盖壳聚糖涂层以增强细胞黏附性。通过调控PLGA分子量和羟基磷灰石含量实现降解速率与软骨再生速率匹配。支架内部嵌入载有地塞米松与TGF‑β的微球。制备方法结合熔融沉积3D多喷头协同打印技术与患者CT/MRI数据建模。相较于传统不可降解材料及现有可降解支架，本发明兼具力学适应性、降解可控性、药物功能集成化及临床适配性优势，适用于先天性鼻畸形、外伤性缺损修复及联合自体软骨移植治疗，有效解决了现有材料生物相容性差、降解速率失配及通用性不足等问题。
Resumen de: CN120662830A
本发明提供了一种梯度致密度金属植入物增材制造方法，涉及激光选区熔化增材制造技术领域，该方法通过多模态传感器融合与自适应控制算法，实现金属植入物从外层到内层的连续梯度致密度分布，精确模拟骨骼的生物力学特性，从而省去设计多孔结构的步骤；可精确模拟人体骨骼的皮质骨(高致密)与松质骨(多孔)结构，提升植入物的生物力学适配性。
Resumen de: WO2025191557A1
The present invention provides a polymeric chain made of acrylate-containing imidazolidinyl urea monomers and having antimicrobial properties, a UV polymerizable resin comprising said polymeric chain, and a product such as a medical device, obtained by 3D printing of said UV polymerizable resin.
Resumen de: WO2025191563A1
The present invention is directed to a method for 3D printing of cells attached to a cell scaffold by simultaneous printing of a first composition comprising thermoresponsive microparticles and a second composition comprising cells. Further provided a printed 3D object such as an implant, comprising cells attached to the cell scaffold of the invention.
Resumen de: DE102024107710A1
Die Erfindung betrifft ein Verfahren zur Herstellung von Tabletten (2), wobei dass das Verfahren einen Beschichtungsschritt und einen auf den Beschichtungsschritt folgenden additiven Fertigungsschritt aufweist, wobei im Beschichtungsschritt über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) beschichtet werden, um Vorläufermaterialpartikel (9) zu erzeugen und im additiven Fertigungsschritt ein selektives Lasersintern eines über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterials (10) zu Tabletten (2) durchgeführt wird.
Resumen de: DE102024107712A1
Die Erfindung betrifft eine Vorrichtung (1) zur Herstellung von Tabletten (2), wobei die Vorrichtung (1) eine Vorläufermaterialherstellungseinrichtung (3) und eine additive Fertigungseinrichtung (4) aufweist, wobei die Vorläufermaterialherstellungseinrichtung (3) ausgebildet ist, um über einen Arzneistoff (5) verfügende Granulatpartikel (6) mit einem ein thermoplastisches Material (7) aufweisenden Beschichtungsmittel (8) zu beschichten, um Vorläufermaterialpartikel (9) zu erzeugen, und wobei die additive Fertigungseinrichtung (4) ausgebildet ist, um aus einem über eine Vielzahl von Vorläufermaterialpartikeln (9) verfügenden pulverförmigen Vorläufermaterial (10) durch selektives Lasersintern Tabletten (2) herzustellen.
Resumen de: US2025288424A1
A method of surgically treating a patient suffering from severe pain and disability of the low back and buttock by stabilizing the patient's spinal column to their pelvis with an implant system including surgical tools and an implant designed to prevent movement between the sacrum and the ilium while being able to attach to a spinal fusion rod which connect to pedicle screws implanted in the bones of the spine of the patient in order to offer lasting relief of the patient's symptoms. The system is designed to address complications in adult spinal deformity by optimizing spinopelvic fixation vis-à-vis the unique biomechanics of the SI joint. The sacropelvic system is a surgical solution which provides an additively manufactured implant at the base of the spine employing an S2AI trajectory while utilizing assisting technologies including surgical navigation and intraoperative neurophysiological monitoring.
Resumen de: US2025288423A1
A method for 3D printing a prosthetic socket from a digital model, including printing a solid wall perimeter of the prosthetic socket with a width achieved in a single pass of a printing nozzle, and forming a plurality of stiffener elements proximate a bottom end of the prosthetic socket, as a function of the printing the solid wall perimeter, is provided. Also provided is a 3D printed prosthetic socket including an upper portion, a lower portion configured to be attached to a prosthetic pylon, and a plurality of stiffener elements radially extending from the lower portion, wherein the upper portion, the lower portion, and the plurality of stiffener elements are printed as a solid wall construction comprised of a printing material deposited using only a single pass of a printing nozzle.
Resumen de: WO2025191493A1
Device for estimating the three-dimensional structure of teeth inside a mouth, comprising : - a central control unit, - a tray insertable inside the mouth, - a plurality of independent cameras arranged on the tray, each camera being equipped with a corresponding fixed focus lens, having a corresponding field of view and being designed to capture a corresponding image of the teeth within the field of view and to transmit the image to the central control unit, each image being composed by a plurality of pixels, and - illumination means arranged on the tray and designed to illuminate the fields of view of the cameras, wherein the central control unit is programmed to estimate the three-dimensional structure of the teeth by estimating independently for each image a depth value for each pixel thereof.
Resumen de: US2025289921A1
The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.
Resumen de: US2025289919A1
The present disclosure provides methods, systems, devices, and kits for creating composite materials from a single resin, the composite materials having multiple continuous phases. The disclosure includes a process to three-dimensionally print objects (e.g., orthodontic appliances) with composite properties. In some aspects, the composite properties are formed from a single formulation with components that, when processed, have hard and soft continuous phases. In some aspects, the composite properties are formed by separately processing the hard phase components and the soft phase components. In some aspects, the composite materials and devices are three-dimensionally printed using the processed material.
Resumen de: US2025289909A1
Polyhydric polymers may be converted to derivatives thereof by reaction with divinyl sulfone to provide vinyl sulfone substituted polymers, where the polymers may additionally be further derivatized, including crosslinked, and the crosslinked and non-crosslinked derivatives may be used in biomedical and other applications.
Resumen de: US2025288524A1
Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.
Resumen de: WO2025193112A1
The invention relates to a three-dimensional printing composition comprising a dECM hydrogel-based biomaterial, a hydrogel made of methacrylated PBS biopolymer derivatives with a radical polymerisation photoinitiator, a methacrylated chitosan solution in 1% acetic acid, neutralised to a final concentration of 3.1 mg/ml in the biomaterial, and/or a chitosan solution in 2% acetic acid, neutralised to a final concentration of 1.4 mg/ml in the biomaterial.
Resumen de: WO2025193110A1
The utility model relates to a chamber with a flow system for the bioprinting and culturing tissue models, containing: a chamber body (1 ) with a central opening obscured by a bottom glass (2), covered from the top by a cover (3) provided with a central opening obscured by a upper glass (5), whereby a silicone circular seal (4) is provided between the chamber body (1) and the chamber cover (3), wherein the chamber body (1) at its two opposite ends is provided with connectors (8) with connecting channels (10) providing a fluid connection to the working volume of the chamber defined by the inner walls of the chamber body (1 ) and the cover (3), the circular seal (4) and the inner surfaces of the bottom glass (2) and the upper glass (5) facing each other, where the flow system is formed by the connectors (8) with the connecting channels (10) and the working volume of the chamber contained between them; and an outer casing of the chamber comprising a bottom frame (6) and a top frame (7), wherein the chamber body (1) and the chamber cover (3), together with the elements contained between them, are enclosed between the bottom frame (6) and the top frame (7) of the outer casing, which are detachably connected to each other.
Resumen de: US2025288331A1
Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.
Resumen de: MX2021013857A
Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure, the two or more scaffold biomaterial subunits being assembled into the composite scaffold biomaterial and held together via gel casting using a hydrogel glue; via complementary interlocking geometry of the two or more scaffold biomaterial subunits; via guided assembly based biolithography (GAB); via chemical cross-linking; or any combinations thereof. Methods for producing such scaffold biomaterials, as well as methods and uses thereof, are also provided.
Resumen de: EP4617061A2
A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame defines a central channel that extends along a central axis. The flow control component is disposed within the central channel and coupled to the outer frame. The flow control component has a set of leaflets mounted within an inner frame. The prosthetic valve is configured to be folded along a longitudinal axis and compressed along the central axis to place the prosthetic valve in a compressed configuration for delivery via a delivery catheter. The longitudinal axis is substantially parallel to a lengthwise axis of the delivery catheter when disposed therein. The prosthetic valve transitions to an expanded configuration when released from the delivery catheter. The flow control component elastically deforms from a substantially cylindrical configuration to a substantially flattened configuration when the prosthetic valve is placed in the compressed configuration.
Resumen de: AU2023377822A1
A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.
Nº publicación: EP4615352A1 17/09/2025
Solicitante:
SPINESAVE AG [CH]
Spinesave AG
Resumen de: WO2024100147A1
A load-carrying rod (1) for an implant system has a structure of individual interconnected solidified droplets (4) so that the transitions from one droplet to another act as crack stoppers in the event of a crack.
BOPI
Sede Electrónica
