Alerta

SYSTEM AND METHOD FOR ANALYTE MONITORING

Resumen de: AU2025257886A1

Apparatuses, systems, and methods for autonomously-initiated analyte measurements and/or calculation of analyte concentrations based on the analyte measurements. An apparatus (e.g., an analyte sensor or a sensing device of the analyte sensor) may be configured to take and sets of sensor measurements at a first frequency having a period equal to a threshold number of cycles of the clock. The stored sets of sensor measurements may include first sets of sensor measurements at the first frequency and second sets of sensor measurements at a second frequency, and the first frequency is greater than the second frequency. Another apparatus (e.g., a transceiver, display device, and/or data management system) may be configured to receive sets of sensor measurements conveyed by the analyte sensor, calculate time stamps for the sets of sensor measurements, and calculate analyte concentrations based on the sets of sensor measurements and the calculated time stamps.

METHODS OF ASSESSMENT OF PRE-CLINICAL ALZHEIMER'S DISEASE

Resumen de: AU2025258407A1

Described herein are methods of assessing the risk of dementia in a subject using an odor-based test, or "smell test". These methods can be self-administered by the subject under the instruction of a computing device via a user interface. Methods of administering a smell test as described herein can optionally be combined with measuring and quantifying the level of at least one biomarker for dementia (e.g., CXCL10, CCL2, IL-6) in a biological sample collected from the subject. Also provided are methods to treat dementia (e.g., dementia associated with Alzheimer's disease, dementia associated with a subset of Alzheimer's disease patients with TDP-43 pathology).

Cartilage Restoration System

Resumen de: US20260335510A1

The Cartilage Restoration System is an injectable hydrogel platform designed to permanently restore, reinforce, and replace fibrocartilaginous and cartilaginous tissues, including intervertebral discs, knee menisci, labra, and articular cartilage, for human and veterinary orthopedic applications, with potential non-orthopedic uses. The system comprises a biocompatible hydrogel precursor with synthetic or natural polymers, natural additives, crosslinking agents activated by thermal, chemical, photochemical, enzymatic, or ionic triggers, and reinforcing agents. Delivered minimally invasively via dual-chamber syringe, catheter, robotic-assisted system, or 3D-printed applicator, the hydrogel polymerizes in situ to form a non-degradable implant with a compressive strength of at least 3-5 MPa, three times that of native tissue. The implant resists degradation, ensures fatigue resistance, and integrates with native tissue through adhesive and bioactive components, sealing defects and supporting lifelong functionality. Modular configurations address disc regeneration, spinal fusion, cartilage repair, and osteochondral defects, with species-specific formulations for veterinary use.

PATIENT-SPECIFIC IMPLANT AND METHOD OF MANUFACTURING SAME

Resumen de: US20260335016A1

A system and method for generating a patient-specific implant is described herein. The system includes a processor configured to receive, from an imaging device, patient-specific image data of a patient's joint; create a 3D model of the patient's joint based on the received patient-specific image data; obtain normative values of joint parameters for a joint type that matches the joint of the received patient-specific image data; modify the 3D model of the patient's joint based on the normative values of joint parameters for said joint type to create a normalized 3D model of the patient's joint; and modify a 3D model of a joint implant based on the normalized 3D model of the patient's joint.

INJECTION DEVICE AND ADD-ON DEVICE

Resumen de: US20260341455A1

0000 Disclosed is an injection device for injecting of a dose of a medicament, the injection device including a housing having a body detachably connectable to a container part configured to accommodate a medicament container, a drive mechanism arranged in the body and operable to expel the dose of the medicament from the medicament container, a first antenna disposed on or in a first portion of the body and configured for wireless signal transmission with an electronic container identifier provided on or in the container part, a second antenna disposed on or in a second portion of the body electrically connected to the first antenna and configured for wireless signal transmission with a transceiver of an electronic module of an add-on device connectable to the injection device, and an electronic device identifier configured for wireless signal transmission with the transceiver.

一時的なタトゥーのためのインクジェット印刷プロセス

Resumen de: US20250108658A1

0000 Provided are temporary tattoos comprising cosmetic inkjet ink and methods of making thereof. The method of making the temporary tattoo may comprise printing, using an inkjet printer, an image made from a cosmetic inkjet ink on a side of a transfer film that comprises an inkjet receptive coating. The image printed on the transfer film may be dried to allow the image to absorb into the coating. Once dried, an adhesive may be applied to the side of the transfer film comprising the inkjet receptive coating to cover the image. Thus, the temporary tattoo may comprise a transfer film comprising an inkjet receptive coating, and an adhesive film.

TIME-BASED WIRELESS PAIRING BETWEEN A MEDICAL DEVICE AND A WALL UNIT

Resumen de: EP4832004A2

0001 A system for use in a healthcare facility having a patient room. The system comprises a patient bed having bed circuitry including a first wireless transceiver and an AC power cord, and a wall module including a housing configured to be mounted at a fixed location in the patient room of the healthcare facility. The housing carries an AC receptacle and has a front wall that is formed to include a first recess in which the AC receptacle is accessible. The wall module further includes module circuitry carried by the housing. The module circuitry includes a second wireless transceiver and an AC plug sensor that forms an optical beam in the recess in front of the AC receptacle. In response to the optical beam being interrupted by a plug of the AC power cord being plugged into the AC receptacle, the second wireless transceiver communicates with the first wireless transceiver to implement a time-based wireless pairing operation between the wall module and the patient bed.

RADICALLY POLYMERISABLE COMPOUND AND COMPOSITION

Resumen de: WO2025131708A1

The invention relates to a radically polymerisable compound represented by a structure of formula 1: PG1-Sp1-OC(O)NH-K-NHC(O)O-Arn-OC(O)NH-K-NHC(O)O-Sp2-PG2 ( formula 1), and to a radically polymerisable composition, to the use of the radically polymerisable compound or the radically polymerisable composition for producing a polymerisable dental material and to a cured dental material.

STAIN RESISTANT COMPOSITIONS AND METHODS FOR PREPARING THE SAME

Resumen de: WO2025137128A1

The present disclosure provides polymerizable composition that can produce desirable stain resistant polymeric materials, polymer compositions, and/or photo-curable resins. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

IMPRESSION TRAY WITH LATTICE STRUCTURE

Resumen de: EP4830663A1

Die Erfindung betrifft einen Abformlöffel zur Anfertigung von Gebissabdrücken mithilfe von Abformmaterial, ein Verfahren zur Herstellung sowie ein nichtflüchtiges Speichermedium , wobei der Abformlöffel umfasst: einen Löffelabschnitt, ausgestaltet zur Aufnahme des Abformmaterials, und einen Halteabschnitt, umfassend einen Haltegriff, wobei der Löffelabschnitt ferner zur Aufnahme eines Gebisses eines Ober- oder Unterkiefers ausgestaltet ist, dadurch gekennzeichnet, dass eine Oberfläche des Abformlöffels zumindest in Teilen des Löffelabschnitts eine Gitterstruktur aufweist, die zur Aufnahme des Abformmaterials ausgestaltet ist.

DIGITAL METHOD FOR MANUFACTURING A DENTAL COMPONENT

Resumen de: US2020222151A1

A system for dental implant restoration is provided. It includes universal aligning adaptors and prosthetic components having co-operable indices, which together form a translational, integrating system which aligns, synchronizes, and references the prosthetic components about an implant's central axis of rotation. Rotation of an adaptor about a prosthetic component, with its reference point becoming aligned to a predetermined reference point on the prosthetic component, followed by the rotation of the adaptor/prosthetic component assembly about the implant, situates the prosthetic component in a predetermined position such that all other prosthetic components become synchronized to the adaptor's reference point. The prosthetic component is mechanical for clinical or lab bench use, or is virtual for restoration design in a software program, prior to milling prosthetic abutments or devices. Abutments, healing caps and screw access holes are realigned to preferred positions and synchronized with minimal deviation from the ideal direction.

SCAFFOLD BASED IMPLANTS

Resumen de: EP4830666A2

0001 Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

Component mixing in 3D bioprinting

Resumen de: GB2705670A

Apparatus 100 suitable for supplying a 3D printer 10, particularly a bioprinter, with a print material, for example bioinks, having a predefined ratio of components, the apparatus comprising plural component reservoirs 130A-C, for example vials, each reservoir holding a material to be printed and being in common fluid communication with a printing nozzle 114, one or more devices 124A-C for generating a pressure in each of the reservoirs for a selectable time period for dispensing a volume of the respective component out of the respective reservoir to the nozzle supply, and thereby to define a ratio of components. A controller 150 for controlling the or each device may be provided, UV light may be applied to the material and the ratio selected influences the intensity of UV the light applied. A method for mixing components of a 3D printable material to a predefined ratio is also provided. Figure 1.

HIS-PURKINJE SYSTEM CAPTURE DETECTION

Resumen de: EP4832013A2

0001 A medical device is configured to receive a cardiac signal and determine a morphology matching score from the cardiac signal and a capture detection morphology template that corresponds to a first type of cardiac pacing capture that includes capture of at least a first portion of the His-Purkinje system. The device is configured to detect a second type of cardiac pacing capture in response to the morphology matching score being less than the first match threshold. The second type of cardiac pacing capture is different than the first type of cardiac pacing capture and may include capture of the ventricular myocardium and/or a second portion of the His-Purkinje system different than the first portion.

动物来源的组织脱细胞化方法及包含动物来源脱细胞化组织的生物墨水

Resumen de: WO2025141426A1

A method of decellularization of animal tissue, comprising the steps of: mechanical homogenization of animal-derived tissue, incubation of the homogenized tissue from step a) in a solution of trypsin and EDTA, subjecting the filtered tissue to incubation in a PBS buffer solution with a pH in the range of 7.2-7.6 containing a non-ionic detergent at a concentration of 4 - 2% and NH4OH at a concentration of 0.2 - 0.08%, rinsing the tissue with a PBS buffer solution containing an antimicrobial agent, incubation in a deoxyribonuclease solution at a concentration of 0.001 to 0.003% (w/v), rinsing the decellularized tissues obtained with a PBS buffer solution containing an antimicrobial agent, wherein the non-ionic detergent is a compound with a molecular weight of 596 g/mol and additional steps of incubating the tissue in the solution PBS buffer with a pH of 7.2- 7.6 containing a non-ionic detergent at a concentration of 1.5-0.5% and NH4OH ata concentration of 0.2-0.08%, where the incubation is carried out at a temperature below room temperature for 36-48h, and incubation of the tissue in a PBS buffer solution with a pH of 7.2-7.6 containing a non- ionic detergent at a concentration of 0.75-0.25% and NH4OH at a concentration of 0.2-0.08%, where the incubation is carried out at a temperature below room temperature for 36-48h. Bioink containing decellularized tissue of animal origin.

放射線被ばくを低減するための医用撮像システム

Resumen de: MX2026002915A

Methods, systems, and apparatuses are described herein for using processes and machine learning techniques to optimize medical imaging processes to reduce inadvertent exposure to harmful radiation. A machine learning model may be trained to output recommended medical imaging device operating parameter settings. Available operating parameters of a medical imaging device may be determined, and patient data may be received. The patient data and the available operating parameters may be used as input to the trained machine learning model, which might output recommended operating parameter settings. In turn, this output in addition to other calculations might be used to transmit, to the medical imaging device, data that causes modification of the operating parameters of the medical imaging device. Metadata corresponding to one or more images captured by the medical imaging device may be received, and the trained machine learning model might be further trained based on that metadata.

针对用于增材制造牙齿修复体的材料的材料存储容器、用于填充材料存储容器的方法以及用于增材制造牙齿修复体的装置和方法

Resumen de: CN122973153A

描述了一种针对用于增材制造牙齿修复体的材料的材料存储容器。所述材料存储容器包括接收空间和供应口，所述供应口以材料输送方式耦合到所述接收空间，以至于材料可以通过所述供应口从所述接收空间供应以用于增材制造所述牙科修复体。至少在至少一项材料特性上不同的第一材料和第二材料被布置在所述接收空间中。所述第一材料和所述第二材料沿所述接收空间的排放方向接连地布置。或所述第一材料和所述第二材料沿垂直于排放方向的方向接连地布置。还阐述了一种用于填充材料存储容器的方法。还解释了一种用于增材制造牙齿修复体的装置和一种用于增材制造牙齿修复体的方法。

基于多组分药料配给的医用敷料3D打印控制方法及系统

Resumen de: CN122976030A

本发明涉及医用敷料3D打印控制技术领域，涉及基于多组分药料配给的医用敷料3D打印控制方法及系统。其包括：获取目标敷设区域轮廓数据及多种药料组分的配给参数；生成打印区域并划分打印单元，构建对应路径段的打印路径；确定各打印单元中不同药料组分的单位面积目标药料量，并结合路径段有效打印宽度及打印头运动速度确定供料参数；根据边缘承载状态和易迁移药料配给状态确定边缘药料逸散风险系数及配给修正量，在边缘修正打印单元与内部相邻打印单元之间重新分配易迁移药料组分，更新单位面积目标药料量并修正供料参数，控制打印头及药料供给通道完成打印。本发明可降低不规则敷料打印中的单位面积药料沉积偏差及边缘易迁移药料脱落风险。

一种Ti13Nb14Zr1Cu医用钛合金及其制备方法和应用

Resumen de: CN122979704A

本发明属于医用植入金属材料技术领域，具体涉及一种Ti13Nb14Zr1Cu医用钛合金及其制备方法和应用，本发明所述合金为β型医用钛合金，以质量百分含量计包含Nb 13%、Zr 14%、Cu 1%，余量为Ti；Nb、Zr用于稳定β相结构并保障生物相容性，Cu以合金化形式均匀分布，赋予材料抗菌性能，并协同提升成骨与促血管生成能力。本发明采用电子束熔融增材制造工艺制备，可构建单元尺寸1.5mm、孔隙率50%～80%的三周期极小曲面G结构三维连通多孔结构，实现成分调控与多孔结构一体化成形。该合金同时兼具成骨促进、抗菌及促血管生成性能，效果优于纯钛，适用于骨缺损修复、牙科植入等医用植入领域。

激光调控改善TC4合金细胞粘附性的方法及TC4合金

Resumen de: CN122974937A

本发明公开了激光调控改善TC4合金细胞粘附性的方法及TC4合金，涉及增材制造材料工艺技术领域；该方法包括如下步骤：分别以激光功率、激光扫描速度、激光扫描间距为单因素变量设置多个不同的激光加工参数组；采用激光粉末床熔融增材制造技术制备TC4钛合金成型件；筛选出具有未熔融孔隙、烧蚀孔隙和致密三种不同孔隙类型的样品；对筛选出的样品进行细胞粘附性实验，获得具有细胞粘附性能的TC4钛合金。本发明通过主动引入烧蚀孔隙，在保证力学性能满足骨植入体要求的同时，大幅降低弹性模量，显著改善细胞粘附性能，有效避免应力屏蔽现象，适用于骨植入体等医疗器械领域。

一种用于大段骨缺损修复的空间流体导向型多通道生物陶瓷支架及其制备方法与应用

Resumen de: CN122973691A

本发明属于骨修复生物材料领域，涉及一种用于大段骨缺损修复的空间流体导向型多通道生物陶瓷支架及其制备方法与应用。所述支架由多层交错堆叠的支撑单元阵列构成，每个支撑单元阵列由多个支撑单元组成且至少部分支撑单元的内部沿其轴向长度方向设置有多个贯通导流通道；所述贯通导流通道通过层间孔隙相互连通，形成由支架边缘区域延伸至中心区域并贯穿支架轴向长度的连续空间流体导向网络。实验结果表明，所述支架在大段骨缺损修复中能够促进缺损区域均匀血管化骨再生。

基于热压渗透和锚定的PEEK-钛合金复合植入物及制备方法

Resumen de: CN122973179A

本发明公开了一种基于热压渗透和锚定的PEEK‑钛合金复合植入物及制备方法。该方法包括构建PEEK基体与钛合金多孔结构模型，在多孔结构朝向PEEK侧设计T型凸台、倒锥形柱或仿生树根状等锚定结构；采用3D打印技术一体成型带锚定结构的TC4多孔构件；采用FDM或注塑成型PEEK基体并预留容纳腔；通过热压处理使PEEK熔体渗入多孔结构及锚定结构间隙，冷却后形成机械互锁与渗透固定的双重结合。本发明解决PEEK与钛合金异质材料界面结合强度不足难题，制得复合植入物兼具PEEK与骨匹配的弹性模量和钛多孔结构的优异骨整合能力，界面拉伸剪切强度可达25‑45MPa，适用于股骨髁、脊柱融合器等多种骨植入物。

一种高强抗菌医用钽铜合金复合材料的制备方法

Resumen de: CN122974942A

本发明属于金属增材制造及医疗器械技术领域，具体涉及一种高强抗菌医用钽铜合金复合材料的制备方法。按质量百分比称取94%～96%的球形纯钽粉末和4%～6%的球形铜源粉末，通过声学共振混合后在氩气氛围中真空干燥；将混合粉末铺置于增材制造舱体中，预热基板，先在成形件底部采用低激光功率打印过渡层，再采用高激光功率打印成形件本体，成形舱内氧含量控制在100ppm以下；打印完成后经分离、清洗得到高强抗菌医用钽铜合金植入器械。本发明通过精准控制铜含量（4～6wt.%）实现≥99.99%抗菌率与优异细胞相容性的平衡，通过过渡层和基板预热解决了高熔点钽铜合金打印翘曲问题，压缩强度≥1400MPa，应变≥50%，适用于打印各类骨科、口腔科等植入医疗器械。

一种嵌入-体积复合3D打印方法

Resumen de: CN122973696A

本发明公开了一种嵌入‑体积复合3D打印方法，以海藻酸钠‑明胶复配体系构建热力学稳定的双水相支撑浴，以光交联生物墨水为挤出相，先通过嵌入式挤出在双水相支撑浴内精准沉积出内部异质结构，再向完成嵌入式打印的双水相支撑浴体系中加入光引发剂并混匀，采用可见光进行三维光场投影固化，使所述双水相支撑浴形成外部基体相，同时将内部异质结构封装于外部基体相内，单次流程便可实现多材料、多细胞异质结构一体化成型；100s以内便可完成整体固化，细胞存活率大于80%，可有效解决现有技术难以兼顾高效率、高生物相容性与多材料异质成型的难题。

一种负载miR-210@ZIF-8的应力松弛水凝胶心脏补片、制备方法及应用

Nº publicación: CN122973706A 27/10/2026

Solicitante:

南方医科大学

Resumen de: CN122973706A

本发明涉及生物材料与组织工程领域，涉及一种负载miR‑210@ZIF‑8的应力松弛水凝胶心脏补片，包括复合水凝胶基质，复合水凝胶基质为双交联网络结构，双交联网络结构包括可光交联高分子形成的光交联稳定网络，以及含醛基多糖与含氨基蛋白质通过动态席夫碱键构筑的动态交联网络；动态交联网络具备应力松弛与应力耗散特性，光交联稳定网络维持心脏补片的结构与尺寸稳定性；miR‑210@ZIF‑8纳米颗粒均匀分布于复合水凝胶基质内部，且miR‑210@ZIF‑8纳米颗粒具有酸性响应释药特性。本发明具有能够协同调控心肌梗死后异常力学微环境与缺氧代谢障碍，有效抑制线粒体过度分裂，显著提升心肌修复效果和抗纤维化能力。