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一种生物3D打印培养一体化设备

NºPublicación:  CN120382643A 29/07/2025
Solicitante: 
东北大学
CN_120382643_PA

Resumen de: CN120382643A

本发明属于生物3D打印技术领域,具体的说是一种生物3D打印培养一体化设备,包括:机体,所述机体内壁的顶部滑动连接有密封板,所述机体的内壁均匀设置有导杆,所述机体的内壁靠近密封板的一侧滑动连接有挡板;承托机构,所述承托机构安装在机体内壁的底部,所述承托机构的内壁与导杆的外壁相套接;注入机构,所述注入机构安装在机体内壁的上方,本发明通过设置承托机构,使夹持组件将培养皿固定在承载板的中轴处,并使夹持组件与对齐组件调整注射头的位置,随后进行注射,使打印与培养处于一个机体内完成,避免在注射完成后还需要人工移动培养皿,使细胞的环境发生变化导致难以培养,同时确保在培养过程中使用者可以拆卸注射机构进行清洗。

一种软硅胶-硬塑料构成的包覆结构胆道支架及制造方法

NºPublicación:  CN120381355A 29/07/2025
Solicitante: 
浙江大学
CN_120381355_PA

Resumen de: CN120381355A

本发明公开了一种软硅胶‑硬塑料构成的包覆结构胆道支架,本发明包括防腐蚀内层、硬塑料内芯和包覆式生物相容性外层,防腐蚀内层为管状;硬塑料内芯包括若干个力学支撑结构环,各个力学支撑结构环沿胆道支架的轴向方向依次间隔固定套装在防腐蚀内层的外侧面,包覆式生物相容性外层包括若干个包覆式硅胶件,每个力学支撑结构环的外表面包覆有一个包覆式硅胶件,且每个包覆式硅胶件均一体成型于防腐蚀内层上。本发明可以提供与原生胆道相匹配的力学特性与生物相容性,能够并降低对胆道黏膜的刺激,承受胆汁腐蚀、减少细菌粘附、可长时间使用以及可以弯曲扭转以满足人体正常生理活动需求。

一种牙槽骨骨增量屏障膜及其制备方法

NºPublicación:  CN120381561A 29/07/2025
Solicitante: 
大博创新科技研发中心有限公司
CN_120381561_PA

Resumen de: CN120381561A

本发明涉及医疗器械技术领域,尤其是涉及一种牙槽骨骨增量屏障膜及其制备方法。本发明提供的牙槽骨骨增量屏障膜包括通过3D打印技术制得的氧化锆膜;所述牙槽骨骨增量屏障膜包括牙槽嵴面、唇侧面和舌侧面,所述唇侧面和所述舌侧面位于所述牙槽嵴面相对的两侧;所述唇侧面和/或所述舌侧面上设置有固定孔,所述固定孔的总个数为至少两个;所述牙槽嵴面上设置有透气孔。本发明的牙槽骨骨增量屏障膜具有优异的机械性能和生物相容性,组织粘黏性低;能够更好的贴合患者牙槽骨缺陷处。

骨骼细胞提取羟基磷灰石制备3D打印油墨的方法

NºPublicación:  CN120383773A 29/07/2025
Solicitante: 
西安微动力健康管理有限公司
CN_120383773_PA

Resumen de: CN120383773A

本发明公开了一种骨骼来源羟基磷灰石制备3D打印油墨的方法,通过骨骼预处理、脱细胞、纳米化及复合油墨配制技术,实现天然HA的高效提取与打印应用,兼具环保性、情感价值及艺术创新。

METHOD FOR ARRANGING SUPPORTING STRUCTURES FOR THE ADDITIVE MANUFACTURING OF A DENTAL RESTORATION

NºPublicación:  ES3032955T3 29/07/2025
Solicitante: 
IVOCLAR VIVADENT AG
Ivoclar Vivadent AG
US_2024025122_PA

Resumen de: US2024025122A1

A method for arranging support structures for an additive manufacturing process on a dental restoration, comprising the steps of detecting (S101) a flash line in a digital model of the dental restoration; and adding (S102) support structures to the digital model for supporting the dental restoration in the additive manufacturing process along the flash line.

SYSTEM AND METHOD FOR PRODUCING PHARMACEUTICAL OBJECTS VIA 3D PRINTING

NºPublicación:  HUE070962T2 28/07/2025
Solicitante: 
PHARMAPRINT LTD LLC [CH]
Pharmaprint Limited LLC
AU_2025205378_A1

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)

A method of photoinduced micro-sculpting of a hydrogel

NºPublicación:  NL2036842B1 28/07/2025
Solicitante: 
UNIV EINDHOVEN TECH [NL]
TECHNISCHE UNIVERSITEIT EINDHOVEN
NL_2036842_B1

Resumen de: NL2036842B1

The present invention relates to a method of photoinduced micro-sculpting of a hydrogel, said method comprising the steps of: i) provision of a hydrogel having a plurality of reactive groups each selected from the group consisting of a -CH group, a -NH group, an -OH group and a combination of two or more thereof, said hydrogel having a surface to be micro-sculpted; ii) provision of a photo-activator; iii) contacting the surface of the hydrogel of step i) with the photo-activator of step ii); and iv) illumination of said photo-activator on said surface using a digital mask and UV light to photo-excite the photo-activator to induce micro- sculpting of said hydrogel. Moreover, the invention relates to a micro-sculpted hydrogel obtainable or directly obtained by the method according to the invention. In addition, the invention relates to the use of a micro-sculpted hydrogel as a construct for cell studies, materials and biomaterials applications, tissue engineering, and soft robotics.

硬化性組成物とその硬化物

NºPublicación:  JP2025109729A 25/07/2025
Solicitante: 
KJケミカルズ株式会社
JP_2025109729_A

Resumen de: US2025206865A1

A curable composition which has high curability and high transparency, while exhibiting good adhesion to various base materials, and which is used in both an aqueous system and an organic system and is applied to UV curing and/or thermal curing; a coating agent composition, a bonding agent composition, an adhesive composition, an ink composition, an aqueous ink composition, an ink composition for three-dimensional modeling, an aqueous coating material composition, a sealing agent composition, a nail cosmetic composition, a dental material and a decorative coating agent, each of which contains this curable composition; and cured products and molded articles of these materials. A curable composition contains: (A) a water-insoluble multifunctional (meth)acrylamide; and (B) a polymerizable compound other than the component (A).

生体関連材料を含む3Dバイオプリンティング、及び関連する方法

NºPublicación:  JP2025523824A 25/07/2025
Solicitante: 
ユニバーシティ・オブ・ルイスビル・リサーチ・ファウンデーション・インコーポレイテッド
JP_2025523824_PA

Resumen de: WO2024015237A1

The present disclosure provides a method of bioprinting a 3-D structure comprising one or more biologically-relevant materials on a super-hydrophobic surface. In one embodiment, the method comprises providing a composition having one or more biologically-relevant materials dispersed within a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined area of the super-hydrophobic surface, wherein the pattern is modeled after a biological structure. The composition having the one or more biologically-relevant materials is then bioprinted atop the hydrophilic surface to form a 3-D structure, wherein the hydrophilic surface maintains the 3-D structure in a desired position or shape on the super-hydrophobic surface.

縫合可能な可撓性材料に用いるための相互侵入高分子網目構造

NºPublicación:  JP2025524119A 25/07/2025
Solicitante: 
ラングバイオテクノロジーピービーシー
JP_2025524119_A

Resumen de: CN119894981A

An advanced fabricated interpenetrating polymer network (AM-IPN) is disclosed, comprising: a primary polymer network; a secondary polymer network, where the secondary polymer network is bound to the primary polymer network by one or more cross-links, where one or more of the primary polymer network, the secondary polymer network, and the one or more cross-links are printed using a synthetic bio-ink. Methods of making and using are also disclosed.

多功能牙科装置及相关方法

NºPublicación:  CN120379615A 25/07/2025
Solicitante: 
福塞特加藤国际控股有限公司
CN_120379615_PA

Resumen de: WO2023222193A1

The invention relates to a series (100) of devices for incrementally modifying the position of the teeth in a person (P), said series comprising at least two devices (10), the devices (10) each comprising at least one jaw device (11, 12), the at least one jaw device (11, 12) being designed in such a way that receiving regions of the jaw device (11, 12) can be placed on a dental arch of the upper jaw (OK, 5) or of the lower jaw (UK, 4) of the person (P), the devices (10) being designed such that, when worn according to a predefined order of said devices (10), they incrementally progressively modify the position of the teeth owing to mechanical interaction between the device and at least one tooth element. The at least one jaw device (11, 12) of the first device (10.1, 10.2) may carry, on its outer side, a first veneering element (N.I.1.2, N.IV.1.2) as a partial region of the first device (10.1, 10.2). The at least one jaw device (11, 12) of the second device (10. n) may carry, on its outer side, a second veneering element (N.I.1.n, N.IV.1.n) as a partial region of the second device (10). The first veneering element (N.I.1.2, N.IV.1.2) may be located at the same position as the second veneering element (N.I.1.n, N.IV.1.n) according to a dental notation. A receiving region of the first veneering element (N.I.1.2, N.IV.1.2) may have a different design and/or position than a receiving element of the second veneering element (N.I.1.n, N.IV.1.n), this difference being capable of cau

一种双相生物活性组织修复支架及制备方法

NºPublicación:  CN120365051A 25/07/2025
Solicitante: 
四川大学
CN_120365051_PA

Resumen de: CN120365051A

本发明公开了一种双相生物活性组织修复支架及制备方法,包括以下步骤:步骤1:磷酸钙陶瓷粉体进行表面改性,得到改性后的磷酸钙陶瓷粉体;步骤2:将改性后的磷酸钙陶瓷粉体、铌酸钾钠压电陶瓷粉体、分散剂、光引发剂、光敏树脂充分混合均匀,球磨后得到光固化树脂浆料;步骤3:按照设计构建3D打印模型,将光固化树脂浆料按照3D打印模型打印即可得到支架坯体;步骤4:支架坯体经清洗、脱脂烧结即可得到所需支架;本发明能够制备兼具良好的力学性能、高效抗肿瘤能力及较好的促骨再生能力的双相生物活性组织修复支架,为临床上骨肿瘤术后骨缺损的修复提供技术支持。

用于制造生物打印纤维结构的系统和方法

NºPublicación:  CN120379823A 25/07/2025
Solicitante: 
安斯百克特生物系统公司
CN_120379823_PA

Resumen de: MX2024014120A

Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

一种基于数字化技术的治疗义齿制作方法

NºPublicación:  CN120360726A 25/07/2025
Solicitante: 
重庆晶美医疗科技有限公司
CN_120360726_PA

Resumen de: CN120360726A

本发明公开了一种基于数字化技术的治疗义齿制作方法,其包括:通过扫描获取患者的口腔数据及颌位关系,根据扫描获得的口腔数据及颌位关系设计上颌义齿和下颌义齿;通过3D打印制成上颌基托实体、上颌牙列实体、下颌基托实体和下颌前牙实体;用粘接剂将上颌牙列实体粘接在上颌基托实体上形成上颌义齿实体,用粘接剂将下颌前牙实体粘接在下颌基托实体上形成下颌义齿实体;向下颌基托实体上的凹槽中填充材料形成树脂平板;对树脂平板进行修正,直至上颌义齿实体与下颌义齿实体建立正确的咬合关系。本发明采用数字化设计与3D打印相结合的方式,制作流程短,能显著缩短治疗义齿的制作周期;且制成的治疗义齿实体和所设计的数字化治疗义齿的一致性高,减少了认为误差。

一种蛋白纳米纤维复合类血管及其制备方法与应用

NºPublicación:  CN120361299A 25/07/2025
Solicitante: 
华南理工大学
CN_120361299_PA

Resumen de: CN120361299A

本发明公开了一种蛋白纳米纤维复合类血管及其制备方法与应用,属于3D打印类血管结构技术领域。本发明首先通过AF和GelMA的氢键相互作用,构建了含有纳米蛋白纤维的凝胶墨水,然后通过嵌入式3D打印方法,利用AF和HA的正负离子相互作用和基质相中引发剂向墨水相中的渗透作用,经过紫外光化学交联和后处理,构建了微观尺度上含有纳米蛋白纤维,宏观尺度上壁厚可调的类血管结构。该类血管结构微观尺度上可模拟细胞外基质微环境的纳米纤维结构,宏观尺度上可模拟人体不同部位血管的壁厚,为体外构建血管样结构提供了一种新策略。

DUAL CROSSLINKED SILK-BASED MATERIALS FOR IN SITU DEPOSITION OR PRINTING

NºPublicación:  WO2025155859A1 24/07/2025
Solicitante: 
TRUSTEES OF TUFTS COLLEGE [US]
TRUSTEES OF TUFTS COLLEGE
WO_2025155859_PA

Resumen de: WO2025155859A1

Disclosure herein concerns a non-crosslinked composition having capacity for double crosslinking. The non-crosslinked composition includes a population of methacrylate-modified silk fibroin fragments, each of the methacrylate-modified silk fibroin fragments comprising methacrylate side chains, a photo-crosslinker, an enzymatic crosslinker and optionally one or more enzymatic crosslinker co-reactants, and water

METHOD AND DEVICE FOR MANUFACTURING TRANSPARENT ORTHODONTIC DEVICE, AND RECORDING MEDIUM

NºPublicación:  WO2025155025A1 24/07/2025
Solicitante: 
OSSTEMIMPLANT CO LTD [KR]
\uC624\uC2A4\uD15C\uC784\uD50C\uB780\uD2B8 \uC8FC\uC2DD\uD68C\uC0AC
WO_2025155025_PA

Resumen de: WO2025155025A1

Disclosed are a method, a device performing the method, and a recording medium, the method comprising the steps of: obtaining, by a processor, specification information about a plurality of standard pre-aligners, which is generated on the basis of statistical information; obtaining, by a reception unit, oral information about a user; determining, by the processor, one of the plurality of standard pre-aligners on the basis of the oral information and the specification information; obtaining, by the processor, a tooth model corresponding to the oral information; and deforming, by the processor, the determined standard pre-aligner to correspond to the tooth model so as to obtain a transparent orthodontic device corresponding to the tooth model.

積層造形方法および積層造形方法によって製造された高圧チャンバー

NºPublicación:  JP2025523712A 24/07/2025
Solicitante: 
アールエックスエアエンタープライゼスエルエルシー
JP_2025523712_PA

Resumen de: MX2024014173A

Aspects of the present disclosure include methods for providing a site for the hyperbaric chamber, installing a deposition system at the site, wherein the deposition system is configured to deposit building materials for constructing the hyperbaric chamber, loading a layout of the hyperbaric chamber into the deposition system, and depositing the building materials according to the layout onto the site.

Method device and recording medium for manufacturing transparent corrective devices

NºPublicación:  KR20250112335A 24/07/2025
Solicitante: 
오스템임플란트주식회사
WO_2025155025_PA

Resumen de: WO2025155025A1

Disclosed are a method, a device performing the method, and a recording medium, the method comprising the steps of: obtaining, by a processor, specification information about a plurality of standard pre-aligners, which is generated on the basis of statistical information; obtaining, by a reception unit, oral information about a user; determining, by the processor, one of the plurality of standard pre-aligners on the basis of the oral information and the specification information; obtaining, by the processor, a tooth model corresponding to the oral information; and deforming, by the processor, the determined standard pre-aligner to correspond to the tooth model so as to obtain a transparent orthodontic device corresponding to the tooth model.

METHOD FOR PRODUCING CELL-BASED FISH CONTAINING FISH MUSCLE SHAPE-MIMICKING MUSCLE USING 3D BIOPRINTING TECHNOLOGY AND CELL-BASED FISH PREPARED THEREBY

NºPublicación:  US2025234907A1 24/07/2025
Solicitante: 
BAOBAB HEALTHCARE INC [KR]
Baobab healthcare Inc
KR_20240051567_PA

Resumen de: US2025234907A1

Provided are a method for producing an edible cell-based fish that can realize actual fish muscle shape and texture, and a cell-based fish prepared thereby. The method for producing cell-based fish containing fish muscle shape-mimicking muscle using 3D bioprinting technology includes the steps of: mixing cells for cultured fish and an edible bioink; printing the cell printing ink in a fish muscle-mimic pattern to form a laminated structure; adding a crosslinking agent to the laminated structure; and culturing the laminated structure to which the crosslinking agent is added into a fish muscle tissue.

LINKAGE APPARATUS FOR PRINTER, PRINTER, AND MEDICAL APPARATUS

NºPublicación:  US2025235165A1 24/07/2025
Solicitante: 
GE PREC HEALTHCARE LLC [US]
GE Precision Healthcare LLC
CN_120348083_PA

Resumen de: US2025235165A1

Embodiments of the present application provide a linkage apparatus for a printer, a printer, and a medical apparatus. The linkage apparatus comprises: a paper compartment assembly, provided with a side opening, a base, a paper tray located in the base, and a paper advancing member disposed opposite the side opening, an end of the paper advancing member opposite the side opening being provided with an advancing plate extending upward; a door assembly, movably connected to the paper compartment assembly and capable of closing or opening the side opening; and a transmission mechanism, one side of which is connected to the door assembly, the transmission mechanism driving the paper advancing member to move toward the side opening along with opening of the door assembly, causing the paper advancing member to, by means of the advancing plate, advance paper in the paper tray to move toward the door assembly.

3D printed artificial bile ducts and manufacturing method thereof

NºPublicación:  KR20250112528A 24/07/2025
Solicitante: 
한양대학교산학협력단부산대학교산학협력단
US_2025229006_A1

Resumen de: US2025229006A1

The present invention relates to an artificial bile duct comprising ursodeoxycholic acid (UDCA), and due to comprising UDCA, the artificial bile duct of the present invention is effective in improving differentiation into cholangiocytes and preventing formation of bile stones.

LIGHT THERAPY LOUNGER AND METHOD OF MANUFACTURING THEREOF

NºPublicación:  US2025235717A1 24/07/2025
Solicitante: 
ENERGY LOUNGER LLC [US]
ENERGY LOUNGER LLC

Resumen de: US2025235717A1

Embodiments of the present invention disclose a light therapy lounger. The light therapy lounger includes a frame including a peripheral wall and an inward protrusion extending internally from an inner surface of the peripheral wall. Further, the light therapy lounger includes a plurality of irradiation boards located on the inward protrusion and including a plurality of irradiation sources. Also, the light therapy lounger includes an upper cover made up of a diaphanous material, the upper cover configured to be located above the plurality of irradiation boards. Each irradiation board includes one or more pressure sensors and several irradiation sources electrically coupled to a first Printed Circuit Board (PCB), a heat sink thermally coupled to the first PCB and located under the first PCB, and a plurality of cooling fans electrically coupled to the first PCB and/or a second PCB, and located under the heat sink.

SYSTEMS AND METHODS FOR MODIFYING SURFACES OF ADDITIVELY MANUFACTURED OBJECTS

NºPublicación:  EP4587222A2 23/07/2025
Solicitante: 
ALIGN TECHNOLOGY INC [US]
Align Technology, Inc
CN_120202085_PA

Resumen de: US2024091906A1

Systems and methods for processing additively manufactured objects are described herein. In some embodiments, for example, a system includes a controller configured to provide one or more control signals; a heater coupled to the controller, where the heater comprises one or more heating elements arranged to heat a blasting medium in response to the one or more control signals; a chamber coupled to the controller, where the chamber comprises an agitatable drum shaped to receive a plurality of additively manufactured objects, and to agitate the plurality of additively manufactured objects in response to the one or more control signals; and an applicator coupled to the controller, where the applicator comprises a nozzle operative to direct, in response to the one or more control signals, a plurality of thermally conductive particles in the blasting medium toward the plurality of additively manufactured objects within the agitatable drum.

回転フレーム装置及び生体適合性足場構築物

Nº publicación: JP2025108455A 23/07/2025

Solicitante:

エンボディ,インコーポレイテッド

JP_2025108455_PA

Resumen de: CA3203473A1

A biocompatible scaffold construct includes a plurality of collagen fiber strands, a first portion of which have been coated by a first biocompatible solution and, optionally, a second portion of which have been coated by a second biocompatible solution different than the first biocompatible solution. The coatings may include cells. And the scaffold is constructed on rotating frame collectors.

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