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3D PRINTING OF 3-LAYERED RETINA AND CHOROID TISSUE

Resumen de: US2025367348A1

A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.

Microneedles and Methods of Manufacture Thereof

Resumen de: US2025367422A1

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

ADDITIVE MANUFACTURING SYSTEM, METHOD AND CORRESPONDING COMPONENTS FOR MAKING ELASTOMERIC STRUCTURES

Resumen de: US2025367876A1

A system for additive manufacturing a medical device, the system comprising a first dispensing system, a second dispensing system, a deposition apparatus, and a deposition substrate on a surface of which the deposition apparatus is configured to deposit at least one elastomeric material into a filament. The deposition apparatus receives the at least one elastomeric material from the first and second dispensing systems in proportions effecting a desired property in the medical device. The deposition apparatus may comprise heating and/or cooling elements, a sonic vibration module, and/or a pneumatic suck-back valve. The deposition substrate may have a configuration corresponding to a desired shape of the medical device and is configured to rotate and/or translate relative to the deposition apparatus. The system comprises a controller configured to control the deposition.

METHOD OF MANUFACTURING A SEAT UNIT FOR A WHEELCHAIR, AND A SEAT UNIT

Resumen de: WO2025250016A1

Herein is disclosed a method of manufacturing a seat unit for a wheelchair, and a seat unit for a wheelchair The method comprises the steps of determining a user's needs for support and pressure relief, and thereafter selecting a basic seat cushion module (1) and a basic backrest module (2) before 3D-printing a seat unit adaptation module (4; 5) using information about the determined support and pressure relief needs of the user, for adapting the basic seat cushion module (1) and/or the basic backrest module (2) to the user. The adaptation module (4; 5) is printed with an open 3D structure (3).

IMPLANT FOR CORRECTING A DEFECT OF A BONE STRUCTURE WITH NAVIGATION FIDUCIALS

Resumen de: JP2024057092A

To provide a system for manufacturing and using an implant for correcting a defect of a bone structure.SOLUTION: The implant includes a first surface comprising a shape configured to interface with a surface of the bone structure. In some examples, the implant includes a second surface opposite the first surface and substantially conformal to the shape of the first surface, the second surface comprising three or more point features on the second surface, wherein the three or more point features comprise a first point feature, a second point feature, and a third point feature that form nodes of a triangle, and each of the three or more point features is recessed below the second surface.SELECTED DRAWING: Figure 5D

歯科用コンポーネントの製造のための放射線硬化性組成物

Resumen de: US2025361406A1

The invention relates to a radiation-curing composition for the manufacture of dental components using the DLP process or SLA process, comprising, based on the total mass of the radiation-curing composition (i) one or more radically polymerizable monomers in a combined mass fraction of 60% or more, (ii) one or more hexaarylbiimidazole compounds in a combined mass fraction in the range of 0.1 to 5%, and (iii) one or more mercaptotetrazole compounds in a combined mass fraction in the range of 0.1 to 5%, wherein the combined mass fraction of fillers in the radiation-curing composition is less than 30%.

OSSEOINDUCTIVE BONE GRAFT PREPARATION FROM HUMAN HARD TISSUES AND METHODS FOR CUSTOMIZABLE BONE REGENERATION

Resumen de: WO2025248557A1

This invention relates to the preparation of bone grafts from human hard tissues, such as teeth, bone, and cartilage, that retain osseoinductive potential. The grafts are processed through optimized lab procedures to preserve their biological activity, achieve sterilization, and minimize water content for enhanced shelf life. These grafts can be formulated into particulate, block, or dough/pastel - like forms. The particulate matter can be combined with body fluids containing growth factors to create a moldable material for packing into bone defects, promoting superior osteogenesis. Additionally, the particulate matter can be used in 3D printing to produce customized grafts with controlled porosity based on CT scans and computer-aided design (CAD). Block grafts can be machined into precise shapes using CAD models and computer-aided machining (CAM).

EXTRUSION-PRINTABLE PHARMACEUTICAL FORMULATION, PRINT CARTRIDGE CONTAINING SUCH A FORMULATION AND METHOD FOR PREPARING A MEDICAMENT USING SAME

Resumen de: WO2025247979A1

The invention relates to a pharmaceutical formulation suitable for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to the use of this pharmaceutical formulation for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to a method for preparing a medicament in the form of unit doses by 3D printing using such a formulation.

FUNCTIONAL GRADIENT LATTICE IN ORTHOPEDIC FIXATION IMPLANT

Resumen de: WO2025250670A1

A three-dimensional ("3D") printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.

バイオプリンタのための着脱可能なプリンタヘッド及びバイオプリンタ

Resumen de: AU2023377822A1

A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.

BLOCK COPOLYMERS SUITABLE AS IMPACT MODIFIERS, PROCESS FOR THEIR PREPARATION AND POLYMERIZABLE MATERIALS COMPRISING THEM

Resumen de: EP4656661A1

Block copolymer according to Formula 1 and methods for producing the same,wherein n is a value of from 5 to 250; W1 is a group according to Formula 2, which is attached to the Si atom of Formula 1 via X:The block copolymers are suitable to improve fracture toughness of radically polymerizable compositions. These compositions are particularly suitable as dental materials.

CARDIAC PACEMAKER CONSTRUCT, METHOD FOR PRODUCING A CARDIAC PACEMAKER CONSTRUCT AND USE THEREOF

Resumen de: WO2024156635A1

The invention relates in a first aspect to a cardiac pacemaker construct comprising a three-dimensional core structure comprising pacemaker cells and fibroblasts, produced in vitro, or producible in vitro, by means of an additive manufacturing process and/or a moulding process. A second aspect of the invention relates to a method for producing a cardiac pacemaker construct, in particular a cardiac pacemaker construct according to the first aspect of the invention. A third aspect of the invention relates to a cardiac pacemaker construct obtained or obtainable by the method of the second aspect. A fourth aspect of the invention relates to the use of a cardiac pacemaker construct according to the first aspect, or a cardiac pacemaker construct according to the third aspect, for investigating the effect of substances, in particular harmful substances and/or medications, on the function of the sinoatrial node.

一种血管支架及其制备方法

Resumen de: CN121042562A

本发明提出一种血管支架及其制备方法，对等原子比镍钛合金粉末进行逐层打印得到镍钛支架基体；在镍钛支架基体的表面原位生成氮化钛阻隔层；将表面改性后的镍钛支架置于熔融镁液中，进行无压渗透，以得到互穿相复合结构的Mg‑NiTi复合材料基体；对复合材料基体进行重熔，通过气流雾化制备得到复合材料细粉；采用选择性激光熔化技术和超快激光强化技术对复合材料细粉进行逐层打印，完成二次增材制造，以制备得到目标三维形态的血管支架。经本发明实施例提供的血管支架制备方法所制备的血管支架兼具高力学强度、可控降解周期，避免长期异物留存，可显著降低术后再狭窄率，适用于心血管、骨科等领域。

一种个性化牙齿3D打印设备及其方法

Resumen de: CN121043404A

本发明公开了一种个性化牙齿3D打印设备及其方法，涉及3D打印技术领域，包括打印主体，所述打印主体内设有用于存放液体树脂的树脂框，所述树脂框的上方装配有牵引组件，所述打印主体的前表面安装有能够操控牵引组件往复升降打印义齿的触摸操控屏，所述触摸操控屏的下方设有连接于打印主体前表面的门体；牵引组件包括固定于打印主体内壁的驱动部件。本发明通过铲除组件的设置，能够自动对义齿床上成型的义齿模具以及边料进行铲除，在铲除过程中，通过振动电机的设置，使得铲条能够往复横向振动，进而增加了铲除组件铲除义齿模具以及边料的稳定性，避免了因铲除力度过大而导致义齿模具出现损坏的情况。

一种施源器及其制备方法

Resumen de: CN121041609A

本发明属于近距离放射治疗医疗器械技术领域，尤其涉及一种施源器及其制备方法，施源器采用3D打印技术制备，其原料各组分配比以质量百分比计，Cu：13‑15％，Zr：8‑10％，Mo：8‑10％，Nb：6‑9％，Sn：2.5‑3.5％，Si：0.5‑1.5％，余量为Ti。本发明通过添加Zr、Mo、Nb、Sn等低磁化率元素，将钛合金的磁化率降至纯钛磁化率的1/3，形成一种β相钛合金，再利用3D打印工艺和热等静压工艺制备成型为含ω相的钛合金施源器，其磁化率更小，使MRI成像伪影面积减少，源到位精度更高，降低了对危及器官的不利影响。

用于生产三维丝网印刷工件的设备

Resumen de: WO2024188674A1

The invention relates to an apparatus for producing three-dimensional screen-printed workpieces, in particular a 3D screen printing installation, said apparatus comprising: a printing device for the layer-by-layer production of at least one screen-printed workpiece in a plurality of printing operations; and a transport device for the automated transport of at least one screen-printed workpiece and/or a workpiece carrier to and/or from the printing device, wherein the transport device has at least one transport rail and a conveyor vehicle, which is movably mounted on the transport rail, for at least one screen-printed workpiece and/or at least one workpiece carrier.

患者特异性血管介入球囊的3D打印模型生成系统

Resumen de: CN121043407A

本申请公开了患者特异性血管介入球囊的3D打印模型生成系统，包括影像建模模块从患者DICOM影像提取血管几何与解剖特征参数，生成带解剖特征标注的三维模型，为球囊设计提供基础；球囊构建模块依据血管三维模型中的血管曲率和弯曲动力学参数，标记高危区域并升级模型，设计出贴合血管实际的初始球囊三维模型；应力调整模块构建涵盖球囊多方面参数的规则库，通过仿真优化球囊应力分布，防止应力集中；打印处理模块根据优化后的球囊结构，利用3D打印实现材料分区与密度梯度控制，制造出患者专属球囊；此方案能提升球囊与血管的适配性，增强扩张效果，降低手术风险，有力支持个性化医疗。

用于制备糖尿病创面修复水凝胶的3D打印生物墨水及糖尿病创面修复水凝胶

Resumen de: CN121041510A

本发明公开了一种用于制备糖尿病创面修复水凝胶的3D打印生物墨水，包括组分A羟丁基功能化壳聚糖、组分B季铵基与醛基共修饰的甲壳素等；所述组分A由壳聚糖分散在NaOH溶液与异丙醇溶液中，与环氧丁烷反应制得；所述组分B由甲壳素分散在NaOH‑尿素溶液中，与2，3‑二氧基三甲基氯化铵反应，然后将产物分散在水中再与NaIO4反应制得。本发明的3D打印生物墨水，可以直接在伤患创面处进行原位打印形成修复水凝胶，能够完美贴合创面，该水凝胶利于伤口愈合，具备抗菌性能、对细胞无副作用，还可根据糖尿病创面在不同阶段需要不同药物的需求制备出负载不同药物的上下两层结构，实现在不同愈合阶段缓释不同药物，从而显著促进糖尿病等难愈合性创面的愈合。

3D打印正畸牙科矫治器的支撑结构及其制造方法

Resumen de: WO2024216245A1

The present disclosure provides a support of a 3D printed orthodontic dental appliance is provided. The orthodontic dental appliance includes a shell structure defined by an inner contour surface and an outer contour surface. The support comprises: a middle support including a middle support base mesh and a plurality of middle support struts and a main support configured to connect the middle support to a build platform of a 3D printing device used to print the orthodontic dental appliance. One end of each middle support strut of the plurality of middle support struts is connected to the orthodontic dental appliance at a junction of the inner contour surface and the outer contour surface, and the other end of the middle support strut is connected to a rim of the middle support base mesh.

用于治疗骨不连的骨整合式可降解硅胶支架及其制备方法

Resumen de: CN121041523A

本发明公开了用于治疗骨不连的骨整合式可降解硅胶支架及其制备方法，涉及医疗植入材料技术领域，该制备方法包括：使含氢硅油与烯丙基缩水甘油醚在铂催化剂作用下发生硅氢加成反应，生成含环氧基团硅油，随后在催化剂作用下使环氧基团开环，得到侧链含磷酸酯基团的硅油；将端羧基聚乳酸‑乙醇酸共聚物与侧链含磷酸酯基团的硅油混合，在缩合剂和催化剂作用下进行缩合反应，得到PLGA‑P‑PDMS‑PLGA三嵌段共聚物；将三嵌段共聚物、反应性稀释剂、光引发剂和无机增强填料混合制得3D打印浆料；使用光固化3D打印技术，根据设定的打印参数，将打印浆料打印成所设计的骨整合支架。通过本发明赋予了材料本征成骨活性，实现了生物活性、形状记忆功能与力学支撑的统一。

全光纤一体式探测消融诊疗仪及制备方法

Resumen de: CN121040956A

本发明公开了一种全光纤一体式探测消融诊疗仪及制备方法，属于光纤超声传感器与激光消融器领域。包括双包层光纤、介质膜、传感腔、微聚焦锥。双包层光纤用于探测光及消融激光的传输，介质膜和传感腔共同形成法布里珀罗（Fabry‑Pérot,FP）腔以传感超声信号，微聚焦锥提供超声聚焦的作用。本发明解决了现有光纤探测消融器件依赖多纤、结构复杂的问题，并解决了现有空心悬臂结构光纤超声传感器灵敏度较低、频带低的问题。

一种牙套生产用3D打印设备

Resumen de: CN223618264U

本实用新型公开了一种牙套生产用3D打印设备，包括打印设备外壳、打印设备和打印件，所述打印设备外壳的底部内壁上开设有滑动槽，滑动槽内滑动安装有滑动块，滑动块的一端延伸至滑动槽内，滑动块的另一端延伸至滑动槽外，滑动块延伸至滑动槽外的一端固定安装有托板，打印设备外壳的一侧内壁上开设有开孔，托板的一端穿过开孔延伸至打印设备外壳外，托板的底部一侧固定安装有竖杆，打印设备外壳的一侧开设有凹槽，凹槽内滑动安装有横杆。该实用新型在打印设备内设有可水平移动的托板，可以在打印结束之后，水平移动托板，使得托板带动打印件滑出打印设备，可以降低打印件的冷却时间。

一种基于3D打印的微流控芯片制备姜黄素缓释微球的方法

Resumen de: CN121041243A

本发明涉及生物医药材料及药物递送领域，具体涉及一种基于3D打印的微流控芯片制备姜黄素缓释微球的方法，包括：设计微流控芯片结构、利用光固化打印微流控芯片模具、翻模并键合芯片、连接微流控芯片制备姜黄素缓释微球。其中，连续相为含司盘80的矿物油溶液，分散相的成分包括Gelma溶液、姜黄素；将分散相和连续相按设定比例分别注入分散相流道和连续相流道，形成姜黄素液滴微球。本申请所述的方法可以提升姜黄素缓释微球的粒径均一性，提高姜黄素缓释微球的包载量，延长药物的释放周期，加大药物的利用效率。

光敏陶瓷浆料与光固化3D打印生物陶瓷材料及其制备方法和应用

Resumen de: CN121041503A

本发明提供了光敏陶瓷浆料与光固化3D打印生物陶瓷材料及其制备方法和应用，属于医用生物材料技术领域。本发明提供的光敏陶瓷浆料，按质量份数计，包括以下组分：磷酸二氢铝溶胶50~55份，陶瓷粉末20~25份，单体10~15份，光引发剂0.05~0.10份，稳定剂0.01~0.05份，染料0.01~0.05份，水5~10份。本发明提供的光敏陶瓷浆料经3D打印后所得前驱体具有自由压缩复原、剪裁及个体化填补骨缺损部位的特点，打印过程中出现的瑕疵可以进行修剪，打印后所得前驱体结构出现轻微变形可以自行恢复，避免了光敏树脂经3D打印后存在结构固定、不能自由压缩和剪裁的问题。

一种3D打印多孔椎弓根螺钉

Nº publicación: CN223614912U 02/12/2025

Solicitante:

中国医科大学附属盛京医院

Resumen de: CN223614912U

本实用新型公开了一种3D打印多孔椎弓根螺钉，包括钉身部和钉帽部，钉身部包括近钉帽部一端的皮质骨螺纹区和远离钉帽部一端的松质骨螺纹区，钉身部非连接钉帽部一端设有多孔结构区，多孔结构区包括沿钉身部轴向延伸的内芯柱、加强梁和多孔结构，加强梁至少设置一个且加强梁自内芯柱周缘向外延伸，多孔结构环布于内芯柱外周缘。本实用新型通过多孔结构能高效诱导骨组织长入，将螺钉与椎体连成一整体，有效分散应力，增加螺钉稳定性，多孔结构设于螺钉前端椎体部分，能够避免螺钉在椎弓根区域因应力集中导致螺钉断裂，同时，加强梁能够更好的提高螺钉稳定性，减少螺钉多孔区域断裂的可能，更具推广性且提升使用体验感。