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METHOD AND SYSTEM OF CREATING A REPLICA OF AN ANATOMICAL STRUCTURE

Resumen de: AU2025287348A1

Creating a replica of an anatomical structure. In one embodiments a method includes: accepting pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure to create a positive model; creating a negative model from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice, thereby creating a final negative model; placing a zeroing and angling object to align the negative model to a predetermined angle; placing a base tool object by coupling the base tool object to the outside surface; and casting the replica of the anatomical structure using the negative mold. ec e c

HYDROGEL WITH A HYDROPHILIC THICKENING POLYMER AND PARTICLES OF EGGSHELL MEMBRANE, AND ITS BIOPRINTED PRODUCTS

Resumen de: US20260022330A1

A composition which is a hydrogel including, in an aqueous medium: at least one hydrophilic thickening polymer, and particles of eggshell membrane, in an amount of less than 5% by weight of the total weight of the composition, wherein the particles are rod-shaped, needle-shaped or fibrous, having a specific particle size. Also described is a bioink including the composition, a method for manufacturing a 2D or 3D product using the hydrogel, a kit including the hydrogel or bioink, and to uses thereof.

POLYMERIC MICRONEEDLES AND RAPID ADDITIVE MANUFACTURING OF THE SAME

Resumen de: US20260021632A1

The invention generally relates to microneedle devices, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disease comprising administering same. Specifically, the disclosed microneedle devices comprise a plurality of biocompatible microneedles having one or more of: (i) a curved, discontinuous, undercut, and/or perforated sidewall; (ii) a sidewall comprising a breakable support; and (iii) a cross-section that is non-circular and non-polygonal. The microneedles may also be tiered. Alternatively, the microneedles may be tiered. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Positioning Device For Bioprinting

Resumen de: US20260021487A1

A novel portable, and attachable device allows precise positioning of micro-tissues, tumor spheroids, and other biological samples during bioprinting. The device features an interchangeable connector for handling samples of various sizes and uses a manually adjustable pressure system for suction and deposition. A programmable control unit coordinates pressure and positioning based on input commands, enhancing accuracy and consistency in tissue handling. Compatible with multiple bioprinter systems and supporting both manual and automated operation, it streamlines workflows and improves user experience. This device addresses challenges in high-throughput biological positioning, critical for tissue engineering, clinical, pharmaceutical, and research applications. It supports advancements in customized medicine, biological models, and environmental monitoring, meeting the growing demand for precise biologic handling in the multi-billion-dollar bioprinting and biopsy markets. The device offers superior control over tissue biopsy positioning compared to current manual devices reliant on operator skill.

Additive Manufacturing on Machined Assembled Parts

Resumen de: US20260020963A1

An implant having two adjacent solid parts, a third solid part disposed between the two solid parts, and a porous part extending from the solid parts. The implant is fabricated by a process that includes first assembling the solid parts before additively manufacturing the porous part on surfaces defined by the solid parts. This process may include positioning a first fabricated component adjacent to a second fabricated component such that a side surface of the first fabricated component and a side surface of the second fabricated component form a build surface. Then additively manufacturing a structure on the build surface such that the structure extends across and is permanently fixed to both of the side surfaces of the first and the second fabricated components such that the first and the second fabricated components form part of the implant.

SYSTEM ADAPTED FOR PROVIDING A THERMAL, MEDICAL AND THERAPEUTICAL EFFECT AT A SPECIFIC POINT OF BODY OF A PATIENT

Resumen de: US20260020978A1

The present invention relates to a system (1) adapted for providing a thermal and therapeutical effect to a patient (10) at a specific point of his body. The system comprises an element of contact (20a, 20b), adapted to be placed in contact to the point of body. The element of contact comprises a structural element (21) defining a tridimensionality shape. The system also comprises a thermal regulation device (50) and a regulation fluid circulating through the thermal regulation device and the element of contact. The present invention also relates to a process adapted to manufacture such a structural element.

CUTTING BLOCK

Resumen de: US20260020865A1

A low-cost disposable. 3-D printed cutting guide. The cutting guide may be made with modular attachment spikes. The cutting guide may be provided in connection with a femoral trial for use in preparing a patient's bone to receive an implant.

DEVICE AND METHOD FOR FOOTWEAR CUSTOMIZATION

Resumen de: US20260020643A1

A device and method for the formation of customized footwear insoles and pads is provided. The system employs computers operatively engaged to scanning components to produce individual electronic footprints of a foot of a wearer. Software operating to the tasks of employing the digital data from one or a plurality of electronic footprints, correlating to scans of the feet of a footwear user, will customize an insole or pad for positioning in the footwear to more comfortably support the foot therein.

SYSTEM AND METHOD FOR CREATING TISSUE

Resumen de: US20260022324A1

A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

インプラントおよびインプラントの形成方法

Resumen de: EP4484167A2

Embodiments herein relate to a three-dimensional implant for tissue reconstruction or tissue augmentation for insertion into a patient and a method for forming thereof. The implant comprises a plurality of strands forming a three-dimensional structure. The three-dimensional structure comprises a plurality of hollow channels. Each hollow channel comprises a plurality of sidewalls. A sidewall comprises a plurality of strand segments and a plurality of gaps arranged alternatingly so that a gap is formed between adjacent strand segments of the sidewall. The gap comprises a gap length (gl) and a resting gap height (gh). The plurality of gaps are reversibly expandable gaps. The height of the gap increases due to an object being received by the gap which causes a deflection (δ) in each of the adjacent strand segments, and the height of the gap decreases due to the object being removed from the gap. The plurality of strands are formed from a material having a yield strength (σyield) and elastic modulus (E). A ratio of a radius (R) of the plurality of strands to a square of the gap lengths (gl) of a reversibly expandable gap is based on the yield strength (σyield) of the material, the elastic modulus (E) of the material and a deflection capability δ of a strand segments of the gap, wherein the deflection capability (δ) is the deflection of the adjacent strand segments caused by the insertion of the object into the gap. The ratio of the radius (R) of the plurality of strands (101)

ビッグデータ基盤を活用した人工臓器作製システム

Resumen de: KR20240084787A

The present invention relates to a system for manufacturing artificial organs based on big data. the system for manufacturing artificial organs according to the present invention comprises: an input unit for receiving a user's requirement for artificial organs to be manufactured as an input value; a database unit for storing data necessary for manufacturing artificial organs; a control unit for manufacturing artificial organs by inputting the input value to an artificial organ manufacturing algorithm learned based on the database unit; and a bio printer for manufacturing artificial organs according to the control of the control unit.

CURABLE COMPOSITION WITH URETHANE (METH)ACRYLATE MONOMER AND ACIDIC COMONOMER

Resumen de: WO2024191748A2

A curable composition includes a urethane (meth) acrylate monomer and an acidic or latent acidic comonomer. The urethane (meth) acrylate monomer includes 2 to 12 urethane groups and, independently, 2 to 12 (meth)acrylate groups, wherein each of at least two urethane groups is separated from at least one other urethane group or at least one urea group by at most three carbon atoms. The urethane (meth) acrylate monomer has a molecular weight less than or equal to 5,000 grams/mole. In the curable composition, the molar ratio of urethane groups in the urethane (meth) acrylate monomer to carboxylic acid and carboxylic acid anhydride groups in the acidic or latent acidic comonomer is 1:3 to 3:1.

3D BIOPRINTING OF TUMOR TISSUE FOR MECHANISTIC STUDY AND DRUG SCREENING

Resumen de: CN120936704A

Three-dimensional (3D) bioprinted cell culture systems of tumor tissue, methods of making and methods of using the same are described. The 3D cell culture system provides a plurality of compartments and vasculature as well as cell interfaces, including a tumor/non-tumor interface, a tumor-vasculature interface, to reconstruct a tumor immune microenvironment. The hardness of the 3D bio-printed stent can be adjusted to reflect different stages of canceration, including fibrosis, cirrhosis and fatty degeneration; and establishing chemical gradients, such as oxygen levels, to simulate oxidation pressure and hypoxic conditions. The manufacture of 3D cell cultures is achieved by bioprinting, such as micro-forming, injection exclusion, and suspension bioprinting techniques.

SURGICAL CLAMP

Resumen de: AU2024235637A1

A surgical clamp for providing a stable mechanical grasp and stabilisation of bone during an orthopaedic surgical procedure, comprising: a first arm comprising: an extended section comprising a mount at the distal end thereof; and a first jaw portion located at the distal end of the first arm; a second arm comprising: a fastening platform located at the proximal end of the second arm; and a second jaw portion located at the distal end of the second arm; engagement means comprising a bolt to engage the first arm with the second arm about a pivot point formed by the engagement means to provide relative rotation of the first and second arms between: an open configuration whereby first jaw portion and second jaw portion are urged apart; and a clamped configuration whereby first jaw portion and second jaw portion are urged into clamping engagement with the patient's bone in use during the surgical procedure; a fastening component comprising a fastening bolt and a fastening nut, adapted to engage the first and second arm into a locked clamped configuration about the bone of a patient during the surgical procedure; and a handle adapted to be gripped by a surgical assistance for stabilisation of the patient's joint or bone during the surgical procedure.

ANTI-INFECTION CATHETER AND MANUFACTIRUNG METHOD

Resumen de: US2025128021A1

Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

THIOLATED RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Resumen de: CN120917036A

A recombinant bacterial collagen-like protein, preferably having an amino acid sequence at least > = 60% identical to the amino acid sequence of SEQ ID NO: 1, where the amino acid sequence comprises the deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO: 1, where the recombinant collagen-like protein is functionalized with at least one thiol group. The present invention relates to a functionalized recombinant bacterial collagen-like protein, a bio-ink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent, and optionally at least one photoinitiator, a method of producing a hydrogel by cross-linking the functionalized recombinant bacterial protein or the bio-ink, and the hydrogel obtained thereby. In addition, a scaffold for tissue engineering comprising the hydrogel.

PHOTOCURABLE POLYMERS AND COMPOSITIONS FOR 3D PRINTING RESINS

Resumen de: US2024400859A1

The present disclosure provides a miktoarm polymer having the following structure:where polymer chain 1, 2, 3, 4, A1 and A2 are as defined herein. These miktoarm polymers can produce desirable polymeric materials and being used as a component in photo-curable resins. Further provided herein are methods of producing miktoarm polymers, as well as compositions, resins, devices, and polymeric materials by use of the same. Also provided herein are methods of using miktoarm polymers, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

NEBULISER

Resumen de: EP4389180A1

The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets to thereby generate an aerosol comprising the one or more droplets ejected by each droplet ejector.

MIXTURE, POLYMER, DENTAL POLYMER FOR 3D PRINTING AND MEDICAL PRODUCT THEREOF

Resumen de: WO2024189111A1

The present invention relates to a mixture, for 3D printing, particularly a resin for 3D printing comprising - a monomer, oligomer or polymer, or a mixture thereof, comprising at least one acrylate or methacrylate subunit, and - a lactam, characterized in that the lactam concentration is 0.001 to 0.3 wt%, particularly the lactam concentration is 0.001 to 0.15 wt%, more particularly the lactam concentration is 0.01 to 0.1 wt%. Furthermore, the present invention relates to a polymer, in particular a dental polymer or an otoplastic polymer comprising polymerised monomers and/or oligomers or polymers and a lactam, as well as a medical product comprising said polymer.

SYSTEM, DEEP-DRAWING DEVICE AND METHOD FOR FORMING A DEEP-DRAWN OBJECT

Resumen de: WO2024189093A1

The invention relates to a system (1) for forming a deep-drawn object, wherein the system (1) comprises: - a generative manufacturing device (2) configured to generate a three-dimensional (3D) object on a build platform (3) and - a deep-drawing device (4), characterized in that the deep-drawing device (4) comprises a receiving structure (41) configured to receive the build platform (3), particularly the build platform (3) with the 3D object (5) on the build platform (3), such that when the build platform (3) is received by the receiving structure (41), the deep-drawn object can be generated by the deep-drawing device (4) based on the 3D object (5). The invention also relates to a deep-drawing device (4) and a method for forming a deep-drawn object.

FUNCTIONALIZED RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Resumen de: CN120882736A

A recombinant bacterial collagen-like protein, preferably having an amino acid sequence at least > = 60% identical to the amino acid sequence of SEQ ID NO: 1, where the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO: 1, where the recombinant collagen-like protein is functionalized with at least one non-terminal alkenyl group. The present invention relates to a functionalized recombinant bacterial collagen-like protein, a bio-ink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a method for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bio-ink and the hydrogel obtained therefrom. In addition, the scaffold for tissue engineering comprises a hydrogel.

CROSSLINKERS AND COMPOSITIONS

Resumen de: CN121038767A

The present disclosure provides crosslinker compounds that can produce desired polymeric materials, polymeric compositions, and/or photocurable resins. Further provided herein are methods of producing crosslinker compounds, compositions, resins, devices, and polymeric materials. Also provided herein are methods of making (e.g., by 3D printing) a medical device (e.g., an orthodontic appliance) using a crosslinker compound, a resin, and a polymeric material.

一种面部植入填充材料及其制备方法

Resumen de: CN121360283A

本发明公开了一种面部植入填充材料及其制备方法，涉及医用材料技术领域；所述面部植入填充材料由3D纤维基复合型微球、凝胶基体组成；将3D纤维基复合型微球深入缠绕、互锁在凝胶基体中，呈现高度均匀分散性，从而更加有效地传递应力，提高了材料的机械强度，有利于抵抗植入后变形，两者构建的仿生复合结构通过抵抗降解、维持体积和促进组织长入的方式，实现主动的组织再生与替代，显著提升了填充作用的有效性和长效性。

一种具有主动收缩功能的智能水凝胶及制备方法与应用

Resumen de: CN121360286A

本发明属于3D打印材料技术领域，具体公开了一种具有主动收缩功能的智能水凝胶及制备方法与应用，制备方法包括以下步骤：S1、将3‑丙烯酰胺基苯硼酸加入去离子水中，得到3‑丙烯酰胺基苯硼酸溶液；S2、将单宁酸加入3‑丙烯酰胺基苯硼酸溶液中，得到单宁酸3‑丙烯酰胺基苯硼酸溶液；S3、将苯基‑2,4,6‑三甲基苯甲酰基次膦酸锂、瓜尔豆胶依次加入单宁酸3‑丙烯酰胺基苯硼酸溶液中，得到具有主动收缩功能的智能水凝胶。本发明采用上述一种具有主动收缩功能的智能水凝胶及制备方法与应用，解决现有挤出式3D打印技术中成型精度与结构分辨率不足的问题，为毛细血管网络、神经微导管等精细组织的体外仿生构建提供了新的技术路径。

一种聚谷氨酸生物墨水及其制备方法与应用

Nº publicación: CN121360284A 20/01/2026

Solicitante:

湖南中科要素生物科技有限公司

Resumen de: CN121360284A

本发明涉及一种兼具抑菌和抗氧化功能的聚谷氨酸生物墨水及其制备方法与应用。该方法首先将高分子量γ‑聚谷氨酸在特定高温下降解，获得低粘度、适于打印的降解γ‑聚谷氨酸（dγ‑PGA）；然后将其与甲基丙烯酸酰化试剂反应，制得可光交联的甲基丙烯酰化降解γ‑聚谷氨酸（dγ‑PGAGMA）；最后将dγ‑PGAGMA、光引发剂与活细胞混合，即得所述生物墨水。本发明不仅适合3D生物打印可以任意成型，打印成型的水凝胶能兼具抑制细菌存活和具有抗氧化的功效，能促进软骨细胞的生长和软骨组织的再生。