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165
resultados
Última actualización
02/10/2025 [07:15:00]
Resultados 100 a 125 de 165
Resumen de: US2025283035A1
The bioink disclosed herein includes one or more cells, a carrier material, and microspheres. The microspheres can include one or more biodegradable polymers and one or more compounds, such as a morphogenic compound. The methods disclosed herein can include three-dimensional bioprinting. Additional methods disclosed herein include producing functional tissue.
Resumen de: US2025283019A1
Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device includes a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, and ligament, and which are integrated with neural processes to better recapitulate physiological conditions, including joint pain. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. The disclosed bioreactor devices enable interrogation of the interplay between the peripheral nervous system and joint tissues. By recording activity in sensory neurons, joint integrity as well as therapeutic efficacy can be monitored in real time.
Resumen de: US2025282974A1
Provided is a photocurable resin composition used for producing a three-dimensional formed article by a liquid tank photopolymerization method, the photocurable resin composition containing (A) a radically polymerizable monomer, (B) an inorganic filler, (C) a photopolymerization initiator, (D) an activated light absorbent, (E) a polymerization inhibitor, and (F) a chain transfer agent, wherein: at least 90 mass % of the component (A) has two or more (meth)acryloyl groups in the molecule, and is composed of a polyfunctional (meth)acrylate-based radically polymerizable monomer (a) having 5 to 25 atoms constituting a main chain of a divalent group interposed between the two or more (meth)acryloyl groups; and the component (a) is composed of a polyfunctional monomer a1 having a specific group such as a urethane group and a polyfunctional monomer a2 other than the polyfunctional monomer a1. Also provided is a method for producing a three-dimensional photoformed article by using the photocurable resin composition.
Resumen de: US2025281680A1
Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.
Resumen de: US2025281670A1
Provided is a three dimensional (3D) printing photo-curing composition suitable for skull repair. The 3D printing photo-curing composition suitable for skull repair includes the following components: nanoclay; a photo-crosslinking hydrogel; at least one photoinitiator; and at least one photoresist.
Resumen de: US2025281669A1
Provided is a method for preparing a skull flap by photo-curing 3D (three dimensions) printing, including the following steps: (1) constructing a 3D printing model: generating a corresponding 3D model based on a cranial scan data of a patient; (2) preparing a 3D printing ink: weighing a photo-crosslinking hydrogel, mixing the photo-crosslinking hydrogel and a nanoclay solution to obtain a mixed system, and then adding a photoinitiator and a photoresist into the mixed system to obtain the 3D printing ink; and (3) conducting photo-curing 3D printing: subjecting the 3D printing ink to ultrasonic mixing, then filling into an ink tank of a photo-curing 3D printer, transferring the corresponding 3D model into the photo-curing 3D printer, and subjecting the corresponding 3D model to printing to obtain the skull flap; wherein the nanoclay solution comprises an extracellular matrix component.
Resumen de: US2025281674A1
An exemplary embodiment of the present disclosure provides a method of utilizing partially digested cartilage for chondral defects, the method comprising: obtaining cartilage; mincing the cartilage into a plurality of pieces of cartilage; partially digesting the plurality of pieces of cartilage in a digesting mixture to form partially digested cartilage; and encapsulating the partially digested cartilage.
Resumen de: US2025281310A1
A 3D printed prosthetic liner adapted to provide an interface between a residual limb and a prosthetic socket, specifically a prosthetic liner manufactured using a 3D printing device, the surface of which being treated with one or more applications of a casting resin, and preferably a urethane-based casting resin forming a treated prosthetic liner having enhanced strength and pliability.
Resumen de: US2025281308A1
The invention relates to a prosthesis cover having at least one fastening device (20) for securing the prosthesis cover (1) to a prosthesis component (2), and a flexible main body (10) which has an inner side (11) facing the prosthesis component (2) in the applied state and an outer side (12) opposite the inner side (11), on which outer side the at least one fastening device (20) is arranged, wherein at least one structural element (30) protruding from the outer side (12) is applied to the outer side (12) in an additive manufacturing process.
Resumen de: US2025281441A1
A rapidly-orodispersible tablet containing a porous, bound powder matrix containing droxidopa. The bound matrix contains an acidulant, particularly citric acid, to delay, reduce, or inhibit the coloration of droxidopa during stress storage conditions, and suppress the effect of glycerin on the coloration of droxidopa-containing tablets. The tablet can be dividable along a functional seam printed into the bound powder matrix, to divide the tablet into sub-dosage units of the same mass of droxidopa.
Resumen de: CN119855708A
A method of manufacturing a transfer device includes providing a physical physical model having a shape corresponding to a positive shape of a patient's dental arch and one or more stent assemblies each including a lifting mechanism body releasably connectable to an orthodontic appliance. A transfer device may be formed over the physical entity model, wherein a transfer denture represents a negative replica of at least a portion of the entity model. The transfer device may be used to place the appliance on a patient's dental arch, after which the appliance may be detached from the lifting mechanism body and bonded to the associated tooth.
Resumen de: BE1032411A1
De huidige uitvinding biedt, onder andere, een werkwijze voor het ontwerpen van een steunzool, omvattende het ontvangen van een meting van een voetzool welke verband houdt met druk, genoemde meting bij voorkeur verkregen middels het belasten van een meetoppervlak; het ontvangen van een zoolprofiel; het bepalen, op basis van genoemde meting, van een of meer anatomische zones; het bepalen, op basis van genoemde anatomische zones, van een voetprofiel omvattende een hoofdas; het bepalen, minstens op basis van genoemd voetprofiel en genoemde anatomische zones, van een interpolerend oppervlak; het aligneren van het interpolerend oppervlak met het zoolprofiel, voor het verkrijgen van een gealigneerd 3D-profiel; het genereren, op basis van genoemd gealigneerd 3D-profiel, van een instructie voor het produceren van de steunzool; waarbij genoemd bepalen van het interpolerend oppervlak gebeurt volgens een 3D-karakterisatie volgens respectieve posities (y1, y2) op genoemde hoofdas; waarbij genoemd bepalen van het interpolerend oppervlak het berekenen omvat, op basis van genoemd voetprofiel en genoemde anatomische zones, van een veelheid van telkens ten minste twee ankercoördinaten (d0-d3) liggend in een respectieve dwardoorsnede overeenstemmend met genoemde respectieve posities (y1, y2), en het berekenen, op basis van genoemde ten minste twee ankercoördinaten (d0-d3), van een interpolerend oppervlak.
Resumen de: WO2024094275A1
The present invention relates to a method for interactively designing via an implant design platform an artificial joint implant for hip arthroplasty and corresponding broaching and osteotomy guide apparatuses. The proposed implant design platform reconstructs the anatomy of the patient's pelvic and femoral bones in a 3D digital environment, and accordingly develops a patient-specific femoral implant stem as well as patient-specific surgical tools broach/rasp, osteotomy guide) used in total hip arthroplasty. The patient-specific femoral implant stem developed may be optimized to ensure optimum mechanical performance for the patient, employing complex internal lattices that minimize stress shielding and advanced trabecular surfaces to promote osseointegration.
Resumen de: NL2040421A
A scaffold composite, and a preparation method and use thereof are provided, belonging to the technical field of medical implant materials. A method for preparing a scaffold composite is provided, including: mixing a graphene oxide (GO) dispersion and a polylactic acid (PLA) dispersion, and subjecting a resulting mixed solution to curing and melt extrusion in sequence to obtain a 3-dimensional (3D)— printable GO/PLA composite wire; subjecting the 3D—printable GO/PLA composite wire to 3D printing to obtain a scaffold; and annealing the scaffold to obtain the scaffold composite. The scaffold composite prepared by the preparation method not only exhibits no obvious toxicity to osteoblasts, but also can promote cell proliferation and differentiation. Furthermore, the scaffold composite exhibits a strong ability to induce the formation of new bone, and the osseointegration is more rapid and solid.
Resumen de: CN120201970A
Provided herein are medical devices and methods for treating bone fractures. The medical device includes a body, a stent within the body, and means for concentrating bone growth throughout the body. The device is designed to minimize shear stresses on the distal tip and to distribute micromotion to promote bone ingrowth. The stent may include a three-periodic minimal curved surface (TPMS) having a cubic repeating pattern defining walls within the stent, and the TPMS may be helically wound about a central axis of the device. The device may also contain a biological agent and contain an autologous product. In some embodiments, the medical device is a bone screw or pedicle screw designed to reduce common problems such as screw loosening, screw disengagement, and shaft breakage. The method of treatment involves implanting the medical device into a bone of a patient to aid in fracture healing.
Resumen de: JP2025132775A
【課題】硬化物に曲げ強度を付与することができるチオウレタン（メタ）アクリレート化合物を提供する。【解決手段】２つの下記式（Ｘ）で表される結合と、２つのウレタン結合と、２つの（メタ）アクリロイル基と、を含む、チオウレタン（メタ）アクリレート化合物。式（Ｘ）中、２つの＊は、それぞれ、結合位置である。JPEG2025132775000027.jpg2371【選択図】なし
Resumen de: CN120187366A
Provided herein are medical devices and methods for treating bone fractures. The medical device includes a body having a proximal end and a distal tip, the body housing a stent having porous structures distributed in a proximal grid and a distal grid. The device includes an upper lumen in fluid communication with a first opening at the proximal end, and a lower lumen in fluid communication with a second opening at the proximal end. The device is configured to support independent delivery of cement and cells to the mesh. In some embodiments, the device is a bone screw having a thickened head-neck junction designed to reduce the likelihood of rod breakage during installation. The method includes implanting the device into a bone of a patient, thereby providing an innovative method for fracture treatment.
Resumen de: WO2024097682A1
An indirect bonding (IDB) tray that can be positioned over a single tooth of a patient. The IDB tray can include a well to receive an orthodontic bracket therein. The IDB tray can be 3D printed with a rigid photopolymer material and a soft photopolymer material. The soft photopolymer material may be disposed on a gingival portion of the IDB tray such that the soft photopolymer material can be positioned proximate the gums of the patient to improve patient comfort and/or accommodate gum remodeling due to tooth movement. The soft photopolymer material may be disposed around an inner periphery of the well to facilitate bracket insertion and/or release from the well. The IDB tray can include separation indicia indicating where the IDB tray can be sectioned. The IDB tray can include long axis lines to indicate proper orientation of the IDB tray on a patient's one or more teeth.
Resumen de: EP4613237A2
Systems and methods for securing artificial teeth to a dental prosthetic base with a gradient polymer are disclosed herein. An example system includes one or more processors and a memory communicatively coupled with a 3D printing device and the one or more processors. The memory stores a set of instructions thereon that, when executed by the one or more processors, cause the one or more processors to: generate a print file representative of a polymeric dental prosthesis, the print file including (i) a first material, (ii) a second material that does not chemically bond with the first material, and (iii) a gradient transition zone bonding the first material to the second material that is a gradient polymer of the first material and the second material; and print, via the 3D printing device, the polymeric dental prosthesis based on the print file.
Resumen de: EP4613484A2
Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.
Resumen de: US2025100811A1
An apparatus for processing containers having a transport device which transports the containers to be processed along a predefined transport path has at least one processing device which is configured to process a container in a predefined manner, wherein the apparatus has a movement device, having at least one first guide cam and at least one guide roller which is configured to roll relative to the guide cam. The apparatus also has a detection device which is configured to detect at least one measurement value which is characteristic of a running property of the guide roller relative to the guide cam, and an evaluation device which is configured to evaluate this detected measurement value taking into account at least one further operating value characteristic of the operation of the apparatus.
Resumen de: TW202449426A
Ophthalmic lenses and method of manufacturing ophthalmic lenses are disclosed.
Resumen de: AU2023410422A1
The present invention relates to a crosslinkable polymer composition comprising at least one calcium phosphate, at least one biocompatible and biodegradable organic polymer or one of its precursors, and Zn-ZnO core-shell particles, to a biomaterial obtainable by photopolymerization of such a crosslinkable polymer composition, to a process for preparing such a composition and such a biomaterial, and to the use of such a biomaterial for various applications in the field of health.
Resumen de: CN120605117A
本发明涉及医疗器械领域，具体涉及一种数字个性化牙弓支架，包括与牙列形状相匹配的支架本体，所述支架本体呈波浪形，支架本体上设有牵引挂件和用于将支架本体固定在牙列上的固定部，固定部包括固位环和用于连接固位环和支架本体的连接件，固位环位于相邻两牙根之间且用于安装定位钉，其制作方法，包括对患者上下颌牙列进行扫描，及齿科锥形束CT检查；将三维数据导入三维设计软件中构建牙、牙龈、颌骨三维模型，设计植入钛钉的固位环以及支架曲线，并在支架曲线上设计牵引挂件和用于连接固位环的连接件，通过3D打印得个性化数字牙弓支架。通过实施本方案以提升该牙弓支架与患者口腔的适配精度及安装效率。
Nº publicación: CN120605442A 09/09/2025
Solicitante:
温州大学激光与光电智能制造研究院
Resumen de: CN120605442A
本发明涉及生物医疗技术领域，具体涉及一种具有力学传感功能的伤口治疗微针贴片。该微针贴片包括：柔性基底；设置在上述柔性基底上的微针阵列，上述微针阵列包括多个微针；至少一个上述微针上设有空腔，上述空腔内填充有液态金属。由于微针上设有空腔且空腔内填充有液态金属，当微针插入皮肤后，皮肤组织张力变化导致空腔形变，导致液态金属截面积改变，从而可以通过测量液态金属电阻变化信号分析力学特征。
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