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INDIRECT BONDING TRAY FOR GUM COMPATIBILITY

Resumen de: WO2024097682A1

An indirect bonding (IDB) tray that can be positioned over a single tooth of a patient. The IDB tray can include a well to receive an orthodontic bracket therein. The IDB tray can be 3D printed with a rigid photopolymer material and a soft photopolymer material. The soft photopolymer material may be disposed on a gingival portion of the IDB tray such that the soft photopolymer material can be positioned proximate the gums of the patient to improve patient comfort and/or accommodate gum remodeling due to tooth movement. The soft photopolymer material may be disposed around an inner periphery of the well to facilitate bracket insertion and/or release from the well. The IDB tray can include separation indicia indicating where the IDB tray can be sectioned. The IDB tray can include long axis lines to indicate proper orientation of the IDB tray on a patient's one or more teeth.

眼科用レンズ、その製造方法、及びそれを含む眼科用品の提供方法

Resumen de: TW202449426A

Ophthalmic lenses and method of manufacturing ophthalmic lenses are disclosed.

用于处理容器的装置和容器处理设备

Resumen de: US2025100811A1

An apparatus for processing containers having a transport device which transports the containers to be processed along a predefined transport path has at least one processing device which is configured to process a container in a predefined manner, wherein the apparatus has a movement device, having at least one first guide cam and at least one guide roller which is configured to roll relative to the guide cam. The apparatus also has a detection device which is configured to detect at least one measurement value which is characteristic of a running property of the guide roller relative to the guide cam, and an evaluation device which is configured to evaluate this detected measurement value taking into account at least one further operating value characteristic of the operation of the apparatus.

一种数字个性化牙弓支架及其制作方法、安装方法

Resumen de: CN120605117A

本发明涉及医疗器械领域，具体涉及一种数字个性化牙弓支架，包括与牙列形状相匹配的支架本体，所述支架本体呈波浪形，支架本体上设有牵引挂件和用于将支架本体固定在牙列上的固定部，固定部包括固位环和用于连接固位环和支架本体的连接件，固位环位于相邻两牙根之间且用于安装定位钉，其制作方法，包括对患者上下颌牙列进行扫描，及齿科锥形束CT检查；将三维数据导入三维设计软件中构建牙、牙龈、颌骨三维模型，设计植入钛钉的固位环以及支架曲线，并在支架曲线上设计牵引挂件和用于连接固位环的连接件，通过3D打印得个性化数字牙弓支架。通过实施本方案以提升该牙弓支架与患者口腔的适配精度及安装效率。

一种具有力学传感功能的伤口治疗微针贴片

Resumen de: CN120605442A

本发明涉及生物医疗技术领域，具体涉及一种具有力学传感功能的伤口治疗微针贴片。该微针贴片包括：柔性基底；设置在上述柔性基底上的微针阵列，上述微针阵列包括多个微针；至少一个上述微针上设有空腔，上述空腔内填充有液态金属。由于微针上设有空腔且空腔内填充有液态金属，当微针插入皮肤后，皮肤组织张力变化导致空腔形变，导致液态金属截面积改变，从而可以通过测量液态金属电阻变化信号分析力学特征。

用于牙科领域的生物材料

Resumen de: AU2023410422A1

The present invention relates to a crosslinkable polymer composition comprising at least one calcium phosphate, at least one biocompatible and biodegradable organic polymer or one of its precursors, and Zn-ZnO core-shell particles, to a biomaterial obtainable by photopolymerization of such a crosslinkable polymer composition, to a process for preparing such a composition and such a biomaterial, and to the use of such a biomaterial for various applications in the field of health.

Magnetic Microneedles and Their Manufacturing Method

Resumen de: KR20250133534A

본 발명은 자기장의 인가에 의해 발열 조절이 가능하여 약물 전달을 조절하거나 극대화할 수 있도록 하는 자성 마이크로니들 및 그 제조 방법에 관한 것으로, 본 발명의 자성 마이크로니들은 자성나노입자와 고분자로 제조되어 발열특성과 유연성을 가진다.

カップリング部材、流路接続機構およびインクジェット記録装置

Resumen de: US2025269656A1

A coupling member includes a valve housing and a hollow movable valve. Relative to the valve housing, the hollow movable valve is positionally displaced in an axis direction between a position in a connected state where the coupling member is connected to another coupling member and a position in a disconnected state where the coupling member is disconnected from the other coupling member, thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap is generated between a prescribed part of the hollow movable valve and the valve housing in a radial direction. The hollow movable valve has a circulation opening penetrating through the prescribed part in the radial direction.

一种多功能儿童扩弓器及其制造方法

Resumen de: CN120585489A

本发明专利公开了一种多功能儿童扩弓器及其制造方法，其特征在于，所述多功能儿童扩弓器包括上颌牙套、下颌牙套和胶粘剂，所述上颌牙套外侧咬合面设有上凸台，所述下颌牙套外侧咬合面设有下凸台，所述胶粘剂位于上凸台和下凸台中间。本发明通过胶粘剂粘结上颌牙套和下颌牙套得到一体式结构，结构简单，且通过设置1‑4mm高度上凸台和下凸台来调节双颌距离，使儿童扩弓器具有良好的佩戴舒适度。此外，本发明的儿童扩弓器可用于儿童早矫扩弓、止鼾和防磨牙。本发明中一种多功能儿童扩弓器的制造方法，工序简单，成本低。本发明具有很高的实用价值，值得大范围推广应用。

用于经由装载了API的组织穿透器递送药物的装置和方法

Resumen de: WO2024163828A1

A drug delivery device includes at least one tissue penetrating member configured to embed into tissue, the at least one tissue penetrating member including at least one cavity formed beneath an outer surface of the at least one tissue penetrating member, the at least one cavity having a depth from the outer surface and a width in a direction that is orthogonal to a direction of the depth from the outer surface, and at least one opening in the outer surface that communicates with the at least one cavity so that at least one API loaded into the at least one cavity can be absorbed from the at least one cavity into the tissue, wherein a width of the at least one opening is less than the width of the at least one cavity.

兼具抗肿瘤与骨修复的免疫调节支架及其制备方法与应用

Resumen de: CN120586151A

本发明提供了一种兼具抗肿瘤与骨修复的免疫调节支架及其制备方法与应用，属于组织工程植入材料技术领域。本发明在富醛基3D打印磷酸钙骨架上组装含有MCSF/CSF‑1R和CD47/SIPRɑ通路阻断药物共递送系统的HBC网络，开发了一种能够分阶段激活吞噬肿瘤细胞的巨噬细胞并促进骨再生的治疗性植入物。该植入物显示出与单核细胞/巨噬细胞表面的有效结合，同时显著抑制了骨髓来源单核细胞的M2极化，并增强了巨噬细胞对肿瘤细胞的吞噬能力。本发明的共递送系统负载的两种药物能够发挥协同作用高效抗肿瘤；分解的递送载体能促进骨再生。在体内肿瘤治疗模型中，该治疗支架显著减少了局部M2巨噬细胞，并抑制了肿瘤生长。在体内组织再生模型中，该治疗支架促进了均匀的骨生长。

一种适用于制造器官尺度结构的生物3D打印方法

Resumen de: CN120586157A

本发明公开了一种适用于制造器官尺度结构的生物3D打印方法，包括：将细胞沉淀与水凝胶前体溶液混合制备可用于打印的生物墨水；以生物墨水为原料，利用投影式生物3D打印机打印预设的器官尺度结构；所述水凝胶前体溶液包括水凝胶前体、光引发剂、光吸收剂、密度调节剂、胰酶抑制剂和生理pH缓冲液。由该打印方法制得的器官级3D结构具有精细的打印分辨率和优异的细胞活力，显示了其在组织工程中的潜在适用性；该打印方法具有所需设备简单、操作简便、可快速且批量化制备和成本效益好的优点。由上述方法制得的单取向的器官级3D结构可应用于组织工程与再生医学研究中。

三维（3D）打印系统和方法

Resumen de: US2025276492A1

The disclosure relates to a method for three dimensional (3D) printing an object, the method comprising the steps of:—providing a print job, the print job comprising a representation of the object,—dividing the representation of the object in one or more bodies;—for each body, define settings for printing the respective body, wherein settings for at least one body include filling the body with a porous infill structure;—slicing the representation of the object in a number of slices,—the step of slicing comprising, for the body to be filled with the porous infill structure:—defining for every slice an infill area that is to be filled with the porous infill structure;—defining a circumference of the infill area;—adapting the porous infill structure to the circumference; and—filling the infill area with the adapted infill structure.

基于分形几何结构的植入体及其制备方法

Resumen de: CN120585491A

本发明公开了基于分形几何结构的植入体及其制备方法，所公开的基于分形几何结构的植入体包括植入体本体，植入体本体上设有与生物体组织缺损部位适配的表面，所述与生物体组织缺损部位适配的表面为分形几何结构；所述分形几何结构由若干一级分形各自经过多级分形而形成，所述一级分形为多边形；且由单个一级分形经过多级分形形成的单个高级分形与植入体本体表面面连接。本发明解决了现有植入体表面结构设计和加工受技术限制等原因，导致表面微结构设计与加工难以统一，微结构控形难，影响后续骨结合功效和远期种植体成功率等问题。

一种光热抗菌PETG浆料的牙齿隐形矫正器制备方法

Resumen de: CN120585487A

一种光热抗菌PETG浆料的牙齿隐形矫正器制备方法，涉及本发明一种牙齿隐形矫正器制备方法，以PETG的热塑性流动性温度转变为导向点，乳液与PETG形成局限性空间内的稳态化学键合，进而强化隐形矫正器本征机械性能，通过粘流态PETG、抗菌乳液、光固化树脂之间的层次化官能团间的交互反应形成高透明、高机械、高抗菌的PETG浆料，进一步通过光固化打印技术制备出隐形矫正器，进一步通过高压分散工艺导致抗菌材料在透明硅溶胶中的三维稳态分布并强化界面键合作用。延长隐形矫正器使用寿命，维护口腔健康，实现口腔医疗领域的高价值转化。

一种骨水泥材料及制备方法和用途

Resumen de: CN120586154A

本发明公开了一种骨水泥材料及制备方法和用途，成分为聚酯高分子PEGS‑OH和磷酸钙盐CPC的骨水泥原料中掺杂骨形态发生蛋白‑2，在交联剂的作用下制得所述骨水泥材料，所述骨水泥材料在添加极少量的骨形态发生蛋白‑2情况下即可获得缓释平稳好、成骨活性高等性能的骨水泥材料。

一种缓释药物的界面增强型再生骨支架及其制备方法和应用

Resumen de: CN120586156A

本发明提供了一种缓释药物的界面增强型再生骨支架及其制备方法和应用，属于骨组织工程技术领域。本发明以聚己内酯和羟基磷灰石和作为再生骨支架的基体成分，具有与宿主骨匹配的机械强度和良好的生物相容性；本发明在再生骨支架基体表面和内部孔隙负载聚多巴胺涂层，易于进行表面功能化修饰，聚多巴胺涂层中的邻苯二酚结构能够与MOFs中的金属离子进行配位结合，从而降低MOFs颗粒的脱落率，使MOFs颗粒分布均匀和稳定；本发明使用MOFs颗粒负载杜仲提取物，安全无毒，杜仲提取物包封在MOFs颗粒中，能够提高杜仲提取物的稳定性，实现更好的药物释放效果和促骨再生效果。

用于伤口愈合的基质

Resumen de: AU2023403078A1

The present invention provides articles for the improved healing of wounds, preferably burn wounds. In some preferred embodiments, the article is a matrix formed from a mixture of two or more polysaccharides, the matrix comprising an active ingredient which is an extract from differentiable cells.

PREPARATION METHOD FOR 3D BIOPRINTED TRACHEAL SUBSTITUTE LOADED WITH EPCS

Resumen de: LU509884B1

The invention provides a preparation method for a 3D bioprinted tracheal substitute loaded with EPCs, which includes steps of: S1, preparing a complete decellularized tracheal extracellular matrix free of immunogenicity; S2, preparing an LAP-NC-dtECM hydrogel; S3, isolating and culturing EPCs; S4, preparing an LAP-NC-dtECM bioprinting ink loaded with EPCs; S5, preparing the 3D bioprinted tracheal substitute loaded with EPCs. Combining an acellular trachea to retain complete natural extracellular matrix components, cell nuclei and immune substances are effectively removed so that the invention has excellent characteristics such as being free of immunogenicity, good biocompatibility and the ability to effectively induce angiogenesis in vivo. The invention is prepared into a hydrogel and added with bone marrow EPCs to prepare a printable bioprinting ink, so as to reconstruct a biomimetic tracheal stent with good biomechanical properties and angiogenesis properties in combination of the 3D bioprinting technology.

METHOD FOR GENERATING DENTAL CROWN MODEL AND SYSTEM FOR GENERATING DENTAL CROWN MODEL

Resumen de: WO2025180497A1

Provided are a method for generating a dental crown model and a system for generating a dental crown model. The method for generating a dental crown model comprises: retrieving preset tooth model data according to a target position of a tooth to be treated, wherein the preset tooth model data comprises a plurality of geometrical features; adjusting a preset tooth model by using a plurality of tooth model parameters to obtain adjusted geometrical features; give scores of the matching degree between the adjusted feature points and a plurality of conditional operations; performing weighted operation on the scores to obtain a false tooth score; if the false tooth score is less than a threshold score, inputting the false tooth score into an artificial intelligence unit for parameter correction to obtain a plurality of new tooth model parameters, and continuing adjustment until the false tooth score is greater than the threshold score; and using a tooth model corresponding to final parameters as a dental crown model of a patient.

VASCULARIZED BONE ORGANOID AND CONSTRUCTION METHOD THEREFOR

Resumen de: WO2025179532A1

Provided are a vascularized bone organoid and a construction method therefor. By combining a suspension-based three-dimensional (3D) bioprinting method, a cell-laden printing strategy, and a sacrificial bioink material, a vascularized bone organoid model containing a hollow vascular network is constructed. The vascularized bone organoid model has excellent structural stability, mechanical properties, growth and development capability, and osteogenic capability, involves simple selected materials and fabrication process, implements engineered stable production, allows for long-term co-culture of cells for 3D cultivation, and has high applicability and research potential.

BIO-INSPIRED NEEDLE FOR CONTROLLED RELEASE

Resumen de: US2025276164A1

A micro-needle (MN) patch is formed as an array of 3-D bioprinted structures having a relatively hard planar base with multiple water sensitive barbed tips extending therefrom. The barbed tips are formed from a polymer material configured to exhibit reversible shrink-swell volume change in response to surrounding humidity to facilitate skin penetration under the shrinkage conditions and long-term adhesion when swelling in skin tissues.

SYSTEMS AND METHODS FOR RAPID LIQUID BIOPRINTING

Resumen de: WO2025181649A1

Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.

DENTAL CROWN MODEL GENERATION METHOD AND DENTAL CROWN MODEL GENERATION SYSTEM

Resumen de: US2025275838A1

The present invention provides a dental crown model generation method and a dental crown model generation system. The method includes: retrieving preset dental shape data including multiple geometric features based on the target position of the treated tooth; adjusting the preset dental shape using rotation, stretching, and translation parameters to obtain the adjusted geometric features; scoring the matching degree between the adjusted geometric feature and multiple conditional operations; performing weighted calculations on the scores to obtain a denture score; if the denture score is below a threshold score, inputting the denture score into a parameter correction artificial intelligence unit to obtain new rotation, stretching, and translation parameters, and continuing the adjustment until the denture score exceeds the threshold score; and using the dental shape corresponding to the final parameters as the final dental crown model for the patient.

IMPLANTS HAVING BONE GROWTH PROMOTING AGENTS AND METHODS OF USING SUCH IMPLANTS TO REPAIR BONE STRUCTURES

Nº publicación: US2025275856A1 04/09/2025

Solicitante:

4WEB LLC [US]
4Web, LLC

Resumen de: US2025275856A1

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants may be coated with or include fibers or particles to enhance bone growth around and through the implant.