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一种细胞胶囊生物墨水及其制备方法与应用

NºPublicación:  CN121130169A 16/12/2025
Solicitante: 
湖南中科要素生物科技有限公司
CN_121130169_PA

Resumen de: CN121130169A

本发明涉及一种细胞胶囊生物墨水及其制备方法与应用,包括以下步骤:步骤1:使用细胞膜囊泡与丙烯酸酯‑聚乙二醇‑琥珀亚胺酯(AC‑PEG‑NHS)制备丙烯酸酯化修饰的细胞膜囊泡(mCMVs);步骤2:使用步骤1所得丙烯酸酯化修饰的细胞膜囊泡(mCMVs)与活性因子制得载活性因子的细胞胶囊(PUN@mCMVs);步骤3:将甲基丙烯酸化高分子材料、光引发剂、活细胞与步骤2所得载活性因子的细胞胶囊(PUN@mCMVs)混合,形成可光交联的细胞胶囊生物墨水。本发明创造了一款载药缓释生物墨水,不仅适合3D生物打印可以任意成型,而且能一定的靶向缓释所载的活性因子到所载的细胞中。

用于3D打印树脂的可光固化聚合物和组合物

NºPublicación:  CN121127368A 12/12/2025
Solicitante: 
阿莱恩技术有限公司
CN_121127368_PA

Resumen de: US2024400859A1

The present disclosure provides a miktoarm polymer having the following structure:where polymer chain 1, 2, 3, 4, A1 and A2 are as defined herein. These miktoarm polymers can produce desirable polymeric materials and being used as a component in photo-curable resins. Further provided herein are methods of producing miktoarm polymers, as well as compositions, resins, devices, and polymeric materials by use of the same. Also provided herein are methods of using miktoarm polymers, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

用于制造牙科物件的方法

NºPublicación:  CN121105164A 12/12/2025
Solicitante: 
义获嘉伟瓦登特公司
CN_121105164_PA

Resumen de: US2025375273A1

A method of producing a dental object, including the steps of printing (S101) a substructure; printing (S102) an intermediate layer from a support material on the substructure; and printing (S103) the dental object from the production material for the dental object on the intermediate layer.

用于制造牙科物件的方法

NºPublicación:  CN121105163A 12/12/2025
Solicitante: 
义获嘉伟瓦登特公司
CN_121105163_PA

Resumen de: US2025375275A1

A method of producing a dental object (100), including the steps of printing (S101) the dental object by means of a production material and a support structure by means of a meltable support material layer by layer; melting (S102) the support material; and absorbing (S103) the molten support material in the production material of the printed dental object.

一种形状记忆型多孔的墨水直写打印植入介入类微型医疗器械制品及其制备方法

NºPublicación:  CN121102591A 12/12/2025
Solicitante: 
四川大学
CN_121102591_PA

Resumen de: CN121102591A

本发明提供一种形状记忆型多孔的墨水直写打印植入介入类微型医疗器械制品及其制备方法,是将十二烷二酸与甘油经真空条件下搅拌反应制备得到PGD预聚物,然后加入水溶性无机盐颗粒后经固化得到打印用PGD墨水材料,利用墨水直写3D打印成型,再经固化、去除水溶性无机盐颗粒、冷冻干燥制备得到植入介入类微型医疗器械制品。本发明通过耦合墨水直写打印与PGD制备植入介入类微型医疗器械制品,并基于颗粒渗滤法首次利用水溶性无机盐颗粒赋予PGD基制品多孔结构特征与可药物负载性,实现了临床愈合所需的机械强度和药物负载特性的精确调节战略的有效方案,尤其是为椎间盘退变相关研究相关植入类微型医疗器械制品提出了新思路。

一种显微镜下腰椎手术个性化定制软组织保护装置

NºPublicación:  CN121101769A 12/12/2025
Solicitante: 
河南省洛阳正骨医院(河南省骨科医院)
CN_121101769_PA

Resumen de: CN121101769A

本发明涉及一种显微镜下腰椎手术个性化定制软组织保护装置,包括通路主体、紧缩闭合件和撑开固定件;通路主体包括套筒,套筒侧壁设有沿其轴向延伸的开口,开口两侧壁面的外部对称设置有滑轨;紧缩闭合件包括顶盖和连接在顶盖下的紧缩部件,紧缩部件内侧对称设置有两个与所述滑轨适配的滑槽Ⅰ;撑开固定件包括外侧弧形片、内侧弧形片及连接在外侧弧形片与内侧弧形片之间的撑开部,撑开固定件周向的两侧设有滑槽Ⅱ,滑槽Ⅱ能套设在套筒开口两侧壁面上并沿套筒开口处轴向滑动。本发明结构简单,操作方便,能根据需要的视野范围选择不同规格的撑开固定件使套筒被撑开至理想尺寸,可以个性化定制,与患者身体情况高度适配,可提高手术操作效率,减少并发症和不适情况的发生。

一种复合材料及快速制备方法

NºPublicación:  CN121108714A 12/12/2025
Solicitante: 
四川大学
CN_121108714_PA

Resumen de: CN121108714A

本发明涉及生物导电技术领域,具体涉及一种复合材料及快速制备方法。本发明提供了一种面向生物电子学的新型柔性导电复合材料,其通过将混合体系进行光照成型制备得到。本发明以聚醚F127‑二丙烯酸酯作为弹性网络骨架,溶解在导电聚合物溶液中均匀掺杂导电聚合物,制备得到半互穿双网络水凝胶;随后通过温和冰醋酸处理去除多余小分子并诱导链段重新排列。本发明制备出的生物柔性导电材料具有优异的导电性、机械性能和生物相容性,可以结合3D打印技术来获得具有良好性能的生物柔性电极。本发明从材料体系到制造工艺改进了现有柔性电极导电性低、封装复杂和大尺寸打印受限的瓶颈,为可植入软生物电子学提供了通用、高效的新方案。

一种具有区域差异化物理性能的牙科矫治器及其增材制造方法

NºPublicación:  CN121101779A 12/12/2025
Solicitante: 
上海洲歌科技有限公司
CN_121101779_PA

Resumen de: CN121101779A

本发明涉及牙科医疗器械领域,公开了一种具有区域差异化物理性能的牙科矫治器及其增材制造方法。该矫治器包括由光固化树脂制成的三维壳体结构,所述树脂含有聚氨酯丙烯酸酯和单体。通过调节打印工艺参数,使基体不同区域获得差异化的力学性能,从而在同一矫治器内对不同牙齿施加方向和大小不同的矫治力,以满足临床复杂需求。所述矫治器的材料性能包括:拉伸模量420~2650MPa、屈服强度22~78MPa、屈服应变大于1.8%、断裂应变大于10%、玻璃化转变温度大于40℃,且平均厚度小于2.0mm。本发明方法工艺简便,可提高矫治精度与生物相容性,提升治疗效率。

用于骨缺损修复的可降解梯度多孔Zn@β-TCP复合材料支架及制备方法

NºPublicación:  CN121104087A 12/12/2025
Solicitante: 
太原理工大学
CN_121104087_PA

Resumen de: CN121104087A

本发明属于金属粉末加工技术领域,公开一种用于骨缺损修复的可降解梯度多孔Zn@β‑TCP复合材料支架及制备方法。其中,支架的Zn@β‑TCP复合材料中,优选Zn和β‑TCP的体积分数为97vol.%和3vol.%;支架内部结构为梯度多孔结构,具体是以三周极小曲面为孔隙拓扑结构,孔隙直径为700±50μm~1100±50μm线性过渡。制备方法为通过计算机辅助设计出梯度多孔支架模型,以Zn为金属基体,β‑TCP为增强相,利用激光粉末熔融技术制备出具有梯度多孔结构的Zn@β‑TCP复合材料支架。本发明制备支架中梯度结构设计能够为成骨细胞的黏附、增殖提供更大的空间,有利于营养物质的传输和骨组织的长入。

用于制造牙科物件的方法

NºPublicación:  CN121105165A 12/12/2025
Solicitante: 
义获嘉伟瓦登特公司
CN_121105165_PA

Resumen de: US2025375921A1

A method of producing a dental object, including the steps of printing (S101) a printing layer of the dental object; evaporating (S102) a solvent of the printed printing layer; and detecting (S103) a temperature profile during evaporation of the solvent.

用于预测牙齿移动和制造正畸器具的系统和方法

NºPublicación:  CN121127203A 12/12/2025
Solicitante: 
舒万诺知识产权公司
CN_121127203_PA

Resumen de: WO2024238462A2

A computer-implemented method for predicting tooth positions includes a) defining a plurality of tooth positions corresponding to a plurality of teeth in a dental arch; b) defining a plurality of appliance positions of an orthodontic appliance; c) determining, for each tooth, one or more tooth position differences; d) determining, for each tooth, one or more appliance position differences; e) determining, for each tooth, one or more appliance-tooth relative differences; f) modifying each of the plurality of tooth positions based on the corresponding one or more appliance-tooth relative differences; g) iteratively repeating steps c) to f) until a maximum change in each of the plurality of tooth positions is less than a convergence threshold; and h) defining the plurality of tooth positions obtained in the final iteration of step g) as a plurality of predicted tooth positions.

DRUG-LOADED FILAMENT COMPRISING TOPIRAMATE AND PHARMACEUTICAL PREPARATION FOR PREVENTING OR TREATING OBESITY PREPARED USING SAME

NºPublicación:  WO2025254423A1 11/12/2025
Solicitante: 
THPHARM CORP [KR]
\uC8FC\uC2DD\uD68C\uC0AC \uD2F0\uC5D0\uCE58\uD31C
WO_2025254423_PA

Resumen de: WO2025254423A1

The present invention relates to a drug-loaded filament comprising topiramate and a pharmaceutical preparation for preventing or treating obesity prepared using same. Topiramate contained in the filament exhibits an amorphous nature, and thus can be used in the preparation of a pharmaceutical preparation that is easily dissolved, thereby facilitating application and absorption in the body. The drug-loaded filament comprising same can be applied to 3D printing such as fused deposition modeling (FDM) and effectively used in the preparation of a pharmaceutical preparation that can be administered via various mucosal administration routes, such as oral mucosa, e.g., sublingual and buccal mucosa, and nasal mucosa in the nasal cavity or the like.

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD OF USING SAME

NºPublicación:  US2025375304A1 11/12/2025
Solicitante: 
WARSAW ORTHOPEDIC INC [US]
Warsaw Orthopedic, Inc
US_2025375304_PA

Resumen de: US2025375304A1

An expandable spinal implant includes a plug movably disposed in a distal aperture and an interior portion of a frame. The plug may be configured for movement from a first position to a second position. The plug may include a plug proximal end, an opposite plug distal end, a body portion, and a head portion extending from the body portion to the plug distal end. Movement of the plug from the first position to the second position, and corresponding interaction of a head portion with a first endplate portion may causes the first endplate portion and a first distal end portion to move away from the frame and interaction of the head portion with a second endplate portion may cause the second endplate portion and a second distal end portion to move away from the frame to move the implant from a collapsed position to an expanded position.

Structured solid dosage form

NºPublicación:  US2025375383A1 11/12/2025
Solicitante: 
BLAESI ARON H [US]
Blaesi Aron H
US_2025375383_PA

Resumen de: US2025375383A1

At present, the most prevalent pharmaceutical dosage forms, the oral immediate-release tablets and capsules, are porous solids of compacted drug and excipient powders. Upon ingestion, physiological fluid percolates the open pores, and the dosage form disintegrates and the drug dissolves. Because the pores in the compacted solids are not well connected, however, fluid percolation generally is not uniform, and the drug release rate is difficult to predict and control. To overcome such limitations, therefore, herein a structured solid dosage form is disclosed. The structured solid dosage form comprises a structural assembly of one or more repeatably arranged, extruded structural elements. The elements comprise segments separated and spaced from adjoining segments by free spacings defining one or more substantially interconnected free spaces, or channels, in the dosage form through which a physiological fluid may percolate. The disclosed dosage form enables more predictable drug release rates, and can be readily manufactured by 3D-printing.

DENTAL APPLIANCES AND ASSOCIATED SYSTEMS AND METHODS

NºPublicación:  US2025375266A1 11/12/2025
Solicitante: 
BRIUS TECH INC [US]
Brius Technologies, Inc
US_2025375266_PA

Resumen de: US2025375266A1

The present technology comprises methods of manufacturing an orthodontic appliance. For example, a method can include forming an orthodontic appliance in an intermediate configuration by a casting process. The method can further include securing the appliance to a shape forming fixture such that the appliance assumes a desired configuration. The shape forming fixture can comprise a gingiva portion including a surface having a shape corresponding at least in part to a gingiva of a patient and a securing portion carried by the gingiva portion and configured to releasably secure to a portion of the appliance. The method can further include setting a shape of the appliance while the appliance is secured to the shape forming fixture.

Insertion Aid Apparatus for Diaper Inserts

NºPublicación:  US2025375324A1 11/12/2025
Solicitante: 
LACA ROCIO ISABEL [US]
Laca Rocio Isabel
US_2025375324_PA

Resumen de: US2025375324A1

A diaper insert insertion aid apparatus is disclosed, designed to streamline and simplify the process of inserting absorbent inserts into cloth diaper covers. The apparatus comprises a main body configured to hold multiple reusable cloth diaper inserts, a fastening mechanism to secure the inserts in place, and resilient pads for stability. In one embodiment, the main body further includes a handle for ease of manipulation. The apparatus can accommodate inserts with or without pockets, and the pocketed inserts can be further supported by a dedicated structure within the apparatus. This invention aims to address the inconvenience and physical strain associated with traditional manual insertion methods, making cloth diapering more accessible and appealing to a wider range of users, including those with limited dexterity or handling multiple diapers. The apparatus is adaptable to various insert configurations and can also find possible applications in other textile manufacturing processes.

MULTIFUNCTIONAL HEALTH AND ACTIVITY TRACKER FOR WEARABLE, UNDER-MATTRESS, AND TACTICAL USE

NºPublicación:  WO2025255553A1 11/12/2025
Solicitante: 
EMFIT CORP [US]
EMFIT LTD [FI]
EMFIT CORP,
EMFIT LTD
WO_2025255553_PA

Resumen de: WO2025255553A1

A physiological monitoring device, the device having a housing formed by two rigid structural elements, a soft elastomeric part mechanically locked between the two rigid elements, an electromechanical film sensor assembly positioned beneath the soft part, and a conductive electrode that is arranged above the electromechanical film. The electrode includes electrical connection routed to the printed circuit board (PCB), and the device includes electronics for signal processing, wireless communication, and power management.

ボールプランジャを使用してモデルを固定するための技術

NºPublicación:  JP2025540129A 11/12/2025
Solicitante: 
インスティトゥート・シュトラウマン・アクチエンゲゼルシャフト
JP_2025540129_PA

Resumen de: CN120693245A

This disclosure discusses techniques for securing a thermoformed model, including a locator plate for receiving and securing an individual unique dental model having a polygonal incision, where the locator plate has at least one ball plunger (108) located within a raised polygon (102), the at least one ball plunger has a cylindrical body, a spring, and a ball extending partially outside the cylindrical body. The disclosure also includes a system for thermoforming an orthodontic appliance and a method thereof.

創傷治癒のためのマトリックス

NºPublicación:  JP2025540174A 11/12/2025
Solicitante: 
レゲニクスアーエス
JP_2025540174_A

Resumen de: CN120603611A

The present invention provides articles for improving healing of wounds, preferably burn wounds. In some preferred embodiments, the article is a matrix formed from a mixture of two or more polysaccharides, the matrix comprising an active ingredient, the active ingredient being an extract from differentiable cells.

MINIATURIZED TABLET COATING APPARATUS AND METHOD

NºPublicación:  WO2025255124A1 11/12/2025
Solicitante: 
GENENTECH INC [US]
GENENTECH, INC
WO_2025255124_PA

Resumen de: WO2025255124A1

A method is provided for coating tablets on-demand in a miniaturized coating apparatus. A supply of tablets are provided, each having dimensions and a mass. The supply of tablets together has a total number, a total mass and a total volume. In some aspects, specifications are selected for constructing a customized rotatable drum based on tablet dimensions, tablet number, total mass, total volume, physical and/or chemical properties of coating material(s) to be applied to the tablets, or a combination thereof. In some embodiments, the rotatable drum may be formed by 3D printing.

SCHLIESSEN VON LÖCHERN IN EINEM DREIDIMENSIONALEN DIGITALEN PRÄPARATIONSMODELL

NºPublicación:  DE112024000859T5 11/12/2025
Solicitante: 
EXOCAD GMBH [DE]
exocad GmbH
DE_112024000859_T5

Resumen de: DE112024000859T5

Enthalten ist ein computerimplementiertes Verfahren zum Schließen eines oder mehrerer Löcher in einem unteren Abschnitt eines dreidimensionalen digitalen Präparationsmodells einer Zahnpräparation. Der Zahn ist für die Aufnahme eines Zahnrestaurationselements präpariert, wobei eine untere Grenze des unteren Abschnitts der Präparation in Form einer stufenlosen Kante präpariert ist. Das Verfahren umfasst den Empfang des dreidimensionalen digitalen Präparationsmodells des präparierten Zahns. Ein oder mehrere zu schließende Löcher des dreidimensionalen digitalen Präparationsmodells werden innerhalb des unteren Abschnitts erfasst. Es wird ein Präparationswinkel für die Präparation des unteren Abschnitts bestimmt und das oder die erfassten Löcher werden geschlossen. Das Schließen umfasst eine Extrapolation des unteren Abschnitts in die Löcher unter Verwendung des ermittelten Präparationswinkels.

Culture Apparatus and Printing Method

NºPublicación:  US2025376651A1 11/12/2025
Solicitante: 
SHIMADZU CORP [JP]
SHIMADZU CORPORATION
US_2025376651_PA

Resumen de: US2025376651A1

A culture apparatus includes a bioprinter that linearly prints bioink, a housing configured to accommodate a substrate that supports the bioink, a driver that moves the bioprinter and the housing relatively to each other, and a controller. The controller is configured to control the driver to locate an outlet of the bioprinter at a printing start position in the housing and thereafter to move the outlet in a first direction in the substrate within the housing. The controller is configured to control a pump for the bioink to start application of a pressure to the bioink after the outlet is inserted in the substrate and before the outlet starts moving from the printing start position in the first direction.

POSTERIOR BITE INTERFERENCE ELEMENTS

NºPublicación:  US2025375269A1 11/12/2025
Solicitante: 
INST STRAUMANN AG [CH]
Institut Straumann AG
US_2025375269_PA

Resumen de: US2025375269A1

The present disclosure discusses techniques for fabricating bite interference elements within polymeric dental appliances. The techniques disclose at least one polymeric shell that includes a number of cavities shaped to fit over a patient's teeth. The polymeric shell includes an occlusal appliance surface shaped to fit over an occlusal tooth surface of the patient. One or more bite interference elements are formed within the occlusal appliance surface, and each bite interference element includes a partially disc-shaped feature extending radially away from the occlusal tooth surface when worn by the patient.

POLYMER FILAMENT REINFORCED SCAFFOLD FOR PARTIAL MENISCUS REGENERATION

NºPublicación:  US2025375299A1 11/12/2025
Solicitante: 
RUTGERS THE STATE UNIV OF NEW JERSEY [US]
Rutgers, The State University of New Jersey
US_2025375299_PA

Resumen de: US2025375299A1

A method for fabricating a resorbable scaffold for regeneration of meniscal tissue is disclosed. The method includes fabricating a polymer filament network using 3D printing in accordance with a digital model of the polymer filament network, such that the polymer filament network will include a first plurality of layers comprising the circumferentially-oriented filaments alternating with a second plurality of layers comprising the radially-oriented filaments, the polymer filament network having a three-dimensional shape and geometry between a first layer and a second layer which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

METHOD OF PRODUCING A DENTAL OBJECT

Nº publicación: US2025375275A1 11/12/2025

Solicitante:

IVOCLAR VIVADENT AG [LI]
Ivoclar Vivadent AG

US_2025375275_PA

Resumen de: US2025375275A1

A method of producing a dental object (100), including the steps of printing (S101) the dental object by means of a production material and a support structure by means of a meltable support material layer by layer; melting (S102) the support material; and absorbing (S103) the molten support material in the production material of the printed dental object.

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