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一种基于悬浮生物3D打印的多层骨软骨支架及其制备方法

Resumen de: CN122874654A

本发明公开了一种基于悬浮生物3D打印的多层骨软骨支架及其制备方法，属于生物医用材料技术领域，该多层骨软骨支架包括软骨层、钙化软骨层和软骨下骨层，利用悬浮3D打印技术制备得到，制备软骨层墨水、钙化软骨层墨水和软骨下骨层墨水；软骨层墨水包括基底成分、软骨细胞和聚凝胺；钙化软骨层墨水包括基底成分和成纤维细胞生长因子；软骨下骨层墨水包括基底成分、纳米羟基磷灰石、骨髓间充质干细胞或成骨细胞和骨形态发生蛋白；依次在悬浮支撑浴中进行软骨下骨层墨水、钙化软骨层墨水和软骨层墨水的打印，光固化后即可得到多层骨软骨支架。该多层骨软骨支架生物相容性好、避免了层间连接不紧密的问题。

錠剤印刷装置、錠剤印刷方法および錠剤検査装置

Resumen de: JP2026163520A

0001 【課題】錠剤の検出を良好に行なうことができる錠剤印刷装置、錠剤印刷方法および錠剤検査装置を提供する。 【解決手段】実施形態に係る錠剤印刷装置１は、制御装置が、第１の主撮像装置で撮像される前の錠剤の表裏のいずれかの面を撮像する、照明部を備えた先行撮像装置の撮像画像に基づいて錠剤において撮像された面が表裏のどちらの面であるかを判別し、この判別結果に基づいて、当該錠剤を撮像する際の第１の主撮像装置および第２の主撮像装置の照明部の照明条件を切り替える。 【選択図】図１

一种兽用长效缓释植入式给药装置的精密制造方法

Resumen de: CN122874182A

本发明涉及给药装置技术领域，尤其涉及一种兽用长效缓释植入式给药装置的精密制造方法，该方法首先获取对应治疗场景的多阶段梯度释药需求谱；进而构造反映释药动力学特性的梯度孔隙率特征，并筛选匹配的可降解材料降解区间；同步分析药物扩散速率梯度与材料降解波动，识别由界面粘附及不均匀降解导致的释药偏差区域；建立偏差区域、孔隙连通性变化速率与药物释放动力学模型的映射关系，量化评估腔体结构参数与释药要求的匹配度；最终基于评估结果生成精密加工参数以完成制造。本发明实现了从临床需求到制造参数的精准闭环，有效解决了传统工艺中释药速率偏离预期及批次一致性差的问题，显著提升了微柱的释药稳定性与治疗安全性。

一种术后3D打印瘢痕器及其制备方法

Resumen de: CN122874236A

本发明涉及医疗辅助器具技术领域，具体为一种术后3D打印瘢痕器及其制备方法，旨在解决耳部瘢痕治疗中压力施加不均、不适应个体解剖等现有问题。瘢痕器由医用级光敏树脂支撑，是基于患者患耳三维模型数据定制而成，由三个零部件组成且边缘设有带螺丝的贯穿孔，瘢痕器可以调节对耳部的压力并实现压力均匀分布，瘢痕器制作时先扫描患者耳部获得高精度数据，随后进行三维数据重建，然后3D打印，最后抛光固化消毒处理完成。本瘢痕器能精准复刻患者的耳廓结构，还可以根据瘢痕恢复情况调整压力或重新定制；本发明佩戴舒适美观，能够有效控制耳部瘢痕术后增生，提升患者治疗依从性，还能够提升瘢痕疙瘩治疗的精准性、舒适性和疗效。

一种3D打印腔道插植模板

Resumen de: CN224821376U

本实用新型提供了一种3D打印腔道插植模板，属于医疗器械技术领域。它解决了现有插植模板精确复位与人体连为一体的问题。本3D打印腔道插植模板，包括贯通设有插植针通道和/或宫腔管通道的插入柱，插入柱的尾端上侧设有上固定板，插入柱尾端的左右两侧分别设有一个用于将插入柱固定在人体上的固定翼，固定翼的形状与患者体表轮廓适形/不适形。由于有两侧固定翼的固定，模具不会因触碰插植针而左右晃动，加上腹部的体表定位板，模具与患者完全固定在一起，使得后续操作不会影响模具和插植针的位置，放疗更精准。

錠剤印刷装置及び錠剤印刷方法

Resumen de: JP2026163110A

【課題】錠剤に形状及び配置の少なくともいずれかにおいて不規則な模様がある場合でも、錠剤の外観又は印刷における異常を適切に検出できるようにする。【解決手段】錠剤印刷装置１０００は、搬送機構２０により搬送される、大きさ、形状及び配置の少なくともいずれかにおいて不規則な模様が外面にある錠剤Ｔに印刷する印刷部５０と、印刷部５０による印刷の前段階及び後段階の少なくともいずれかで錠剤を撮像する撮像部（第１の撮像部４０、第２の撮像部６０）と、撮像部と搬送機構２０との間に配置される、模様の色に対応させた光学フィルタ部（第１の光学フィルタ部７１、第２の光学フィルタ部７２）とを備える。【選択図】図１

增材制造牙种植体的干冰低温亲水活化方法及其种植体

Resumen de: CN122875776A

本申请提供一种增材制造牙种植体的干冰低温亲水活化方法及其种植体，属于口腔医学器械表面处理技术领域。该方法包括：提供经增材制造成型的钛合金牙种植体压缩空气预吹扫后，装夹于防磕碰工装上，将防磕碰工装固定于旋转轴上，旋转设备上设置正反转和运行时间，在干冰喷射设备上设置喷射压力，同时启动旋转控制设备和干冰设备，采用干冰低温喷射设备产生干冰颗粒喷射流，对牙种植体表面进行干冰颗粒喷射，得到经干冰低温亲水活化的牙种植体。本申请能够减少外源残留物引入，并改善牙种植体表面亲水活化状态。

一种树脂组合物及其制备方法和应用

Resumen de: CN122878706A

一种树脂组合物及其制备方法和应用，以重量份计，所述树脂组合物包括50~75份无机填料、22~42份树脂基体、0.5~1.5份光引发体系、2~5份增韧剂和0.5~1.5份阻氧助剂；所述树脂基体包括超支化聚酯甲基丙烯酸酯；所述增韧剂包括核壳橡胶粒子、微米级载体和二维纳米增韧片；所述阻氧助剂包括聚乙二醇和三羟甲基丙烷三丙烯酸酯；所述树脂组合物能够实现高无机填料体系下低收缩、高韧性、高疲劳寿命的性能平衡。

一种压低后牙伸长的矫治器与其使用方法

Resumen de: CN122874155A

本发明涉及牙齿纠正的技术领域，尤其涉及一种压低后牙伸长的矫治器与其使用方法，包括第一前牙带环组和第二前牙带环组，第二前牙带环组和第一前牙带环组之间连接有横腭杆；第一前牙带环组和第二前牙带环组的内侧壁上开设有空仓；横腭杆在第二前牙带环组的另一端的两侧设置有固定杆，固定杆与第二前牙带环组的内侧之间设置有内侧连接杆。本发明提供的一种压低后牙伸长的矫治器与其使用方法，通过将相邻支抗牙区域的矫治器，3D打印的金属矫治器强度高，粘接在多颗基牙上，可限制支抗牙移动，在微种植钉的协同下，矫治力得到了很好的表达，矫治效率高。

改善されたＳＬＳ ３Ｄ印刷焼結特性を有するポリカプロラクトン

Resumen de: WO2025073518A1

The present invention refers to a compound particle for 3D printing obtained by hot melt extruding 50 to 90 wt.-% at least one polycaprolactone based polymer; 10 to 50 wt.-% of at least one filler; and optionally up to 5 wt.-% of at least one additive into pellets, wherein the total weight of the components is 100 wt.-%, and thereafter milling the pellets to obtain the compound particle. Furthermore, the present invention refers to a composition for 3D printing comprising a) 94 to 99 wt.-% of at least one compound particle according to the present invention; b) 1 to 6 wt.-% of at least one filler; and c) optionally up to 5 wt.-% of at least one additive; wherein the total weight of a) to c) is 100 wt.-%. Moreover, the present invention refers to a 3D printing method comprising the compound particle or the composition according to the present invention, the article obtained by the 3D printing method and its use as a substitute for bones or a scaffold for broken bones.

SYSTEMS AND METHODS FOR PERSONALIZED BREATH BASED GLYCEMIC MONITORING AND PROJECTED A1C TREND ESTIMATION

Resumen de: WO2026213219A1

A non-invasive glycemic monitoring system uses a breath-sensing device to acquire repeated breath sessions from a user and to generate volatile organic compound information together with sample-quality and environmental information. A computing system receives a lab- derived A1C baseline for the user and uses the baseline with the breath-derived information to initialize and update a personalized model. Accepted breath sessions are stored in a rolling history and used to generate a projected A1C trend and a daily progress score or zone output representative of the user's glycemic trajectory. In some embodiments, humidity, temperature, and sample-quality information are used to normalize breath-session data, and optional external inputs including finger-stick data, continuous glucose monitor data, or other external data are fused with the breath-derived information to refine personalization, anomaly handling, reporting, and confirmatory prompts.

AUTOCLAVE TAG READER FOR ADVANCED HEALTHCARE ARTICLE TRACKING SYSTEM

Resumen de: WO2026213387A1

Various sensing technologies may be used together for an advanced healthcare article tracking system to track items within a hospital (100). Asset tracking may therefore be implemented to provide both humans (118) and robots (114) the ability to track assets (207, 209, 227) as they are stored and moved about within the hospital, with the system also optimizing the scheduling and utilization of operating rooms (102) based on the tracking of the hospital's assets. In one particular instance, an autoclave tag reader (410, 420) may be implemented to sense an autoclave tag (500) and thus track a surgical tool tray (1000) to which the tag is attached from the sterile processing department (104), to the operating room, and back again.

DETECTING AND TRANSMITTING EVENTS ASSOCIATED WITH A SUBJECT

Resumen de: US20260312609A1

0000 Systems and methods for throttling transmitting events associated with a subject are provided. A computer-implemented method can include receiving sensor data collected by one or more sensors associated with a sender device. The computer-implemented method can also include determining an occurrence of an event associated with a subject of the sender device. In some instances, the event is determined based on the sensor data, and the event is associated with a first event type. The computer-implemented method can also include identifying an event-suppression configuration associated with a receiver device, in which the event-suppression configuration identifies a set of event types. The computer-implemented method can also include applying the event-suppression configuration to the event associated with the subject. The computer-implemented method can also include determining that the set of event types includes the first event type.

SYSTEM AND METHOD FOR REAL-TIME MONITORING UTILIZING MACHINE-LEARNING BASED UPON SENSOR DATA

Resumen de: US20260310688A1

System and methods for analyzing data to generate personalized response(s) are disclosed. The method may include, such as by one or more processors, transceivers, and/or sensors: (1) receiving collected sensor data from external data stores; (2) utilizing an NLP model and a computer vision model to categorize the collected data into improvement category, positive category, or neutral category; (3) retrieving policy data corresponding to the user from data store(s); (4) inputting the categorized data and the policy data into a trained machine-learning model to generate personalized responses; (5) generating a presentation of the personalized responses in a device; (6) receiving updated sensor data from the sensor(s) associated with the user; (7) analyzing the updated sensor data to determine a compliance level for the categories to the personalized response(s); (8) comparing the compliance level to a category threshold for the categories; and/or (9) outputting an updated presentation based upon the comparing.

CLASSIFICATION DISPLAY METHOD OF ULTRASOUND DATA AND ULTRASOUND IMAGING SYSTEM

Resumen de: US20260306061A1

Disclosed are a method for displaying ultrasonic data and an ultrasound imaging system. The method may include: acquiring ultrasonic video data to be displayed; obtaining at least one representative frame from the ultrasonic video data; classifying the representative frame to obtain a category of the representative frame, and determining a category of the ultrasonic video data according to the category of the representative frame; and displaying in categories the ultrasonic video data according to the category of the ultrasonic video data.

MODULAR ANALYTE CONNECTIVITY SYSTEM FOR EXTENDIBLE COMMUNICATION WITH DIFFERENT TYPES OF PHYSIOLOGICAL SENSORS

Resumen de: US20260310768A1

0000 A medical device communication system with a modular design to communicate with different types of medical devices, such as physiological sensors. The modular design is implemented using an extensible software library that provides a uniform framework for various applications or third party applications access to medical device data. The modular design also allows for regulated and unregulated portions of the system to be integrated into the system while allowing each portion to be updated separately. The regulated portion of the system may include components, such as sensors and the software library, that are subject to regulatory approval while the unregulated portion may include applications that are not subject to regulatory approval. Thus, the system enables a third party application developer to avoid having to submit the application to a regulatory agency for an application making use of the sensor data.

DOUBLE NETWORKED 3D-PRINTED BIOMATERIALS

Resumen de: US20260306707A1

A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.

MULTI-CHANNELED AND GUIDED INNER CONTROLLING (MAGIC) PRINTHEADS

Resumen de: US20260307330A1

0000 Described are techniques, systems, and methods including those employing multi-channel controlled pneumatic printheads which contain a linker (e.g. Luer lock), a designed functional system (e.g., a microfluidic system, coaxial system, bi/tri-axial, or a mixing system), and one or more outlets (e.g., nozzle part or output linker). The printheads are useful for pneumatic, pressure assisted, extrusion-based 3D printing and emulsion/mixture evaporation for fabricating particles that may encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer.

REGION-BASED MOTION CORRECTION USING EXTRA MODAL INFORMATION FOR SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY

Resumen de: US20260311848A1

0000 For correction of motion in single photon emission computed tomography (SPECT) imaging, extra modal information is used to delineate different regions in a patient. Motion in these different regions as reflected in SPECT data is determined. These regional motions are used for motion correction. Statistical measurements for the SPECT data of the different regions may be used to weight the regional motions.

組換えタンパク質、組換えＤＮＡ配列、ベクター、真核生物および原核生物発現システムおよびそれらの用途

Resumen de: AU2024288436A1

The invention relates to recombinant RE15mR and EJ17zipR hybrid proteins with the structure specified in the description, recombinant DNA sequences encoding recombinant hybrid proteins, vectors containing recombinant DNA sequences, as well as eukaryotic or prokaryotic expression systems transformed with recombinant DNA sequences. The invention also concerns the use of recombinant hybrid proteins as components of bioink intended for bioprinting, and also as components of biomaterials. Furthermore, the invention relates to the use of recombinant DNA sequences, vectors and eukaryotic or prokaryotic expression systems for the production of recombinant hybrid proteins.

METHODS FOR OPTIMIZING TREATMENT TIME AND PLAN QUALITY FOR RADIOTHERAPY

Resumen de: US20260306875A1

Described herein is a graphical user interface that receives a user-specified treatment time value and displays the resultant dose distributions to a target region and/or organs-at-risk (OARs). The dose distributions are depicted as dose volume histograms (DVHs). The user-specified treatment time value may be adjusted as desired and the DVHs for the target region and/or OARs may be correspondingly updated. In some variations, the graphical user interface may comprise bounded DVHs for the target region and/or OARs, where bounds of the DVH represent the range of dose variability between a short treatment time (e.g., Tmin) and a long treatment time (e.g., Tmax). In some variations, the graphical user interface includes a command button that triggers fluence map optimization using the user-specified treatment time.

MULTI-FUNCTION DEVICE FOR IMPROVING SLEEP AND METHOD OF OPERATION THEREOF

Resumen de: US20260306013A1

0000 A multifunction device for improving sleep and methods of use are disclosed herein. The device can comprise an outer housing, a front panel, a front textile wrapped partially around the front panel, a plurality of LEDs within the outer housing, and an internal reflector coupled to the outer housing. The internal reflector can be configured to reflect light generated by the plurality of LEDs towards the front textile such that the light generated by the plurality of LEDs shines through the front panel and the front textile when a sleep-related program of the multifunction device is automatically initiated.

SYSTEMS AND METHODS FOR GENERATING TISSUE DAMAGE SIGNATURES FROM MEDICAL IMAGES FOR SIMULTANEOUSLY ASSESSING TISSUE DAMAGE EXTENT AND DISTRIBUTION

Resumen de: US20260311335A1

A method for assessing tissue damage, disease, or other medical conditions using medical imaging. Medical image data are accessed with a computer system. The medical image data are processed with the computer system to generate tissue signature data that include one or more probabilistic signature profiles that indicate an extent of tissue damage and distribution patterns associated with the tissue damage. A report that indicates an assessment of tissue damage based on the tissue signature profile is generated with the computer system.

OPERATOR-INDEPENDENT ULTRASOUND IMAGING

Resumen de: US20260306065A1

0000 The system includes a wearable device that is operator-independent, and can be utilized in a multiple-transducers configuration to monitor multiple sites simultaneously. The method for monitoring a medical condition of a patient includes receiving an indication that a transducer array is placed at a position in proximity to a body part of the patient to be scanned, the transducer array including a plurality of transducer array elements, the transducer array being a part of a wearable device. The method also includes producing transducer data by scanning the body part. The method also includes conducting a type of test using the transducer data, wherein the transducer array is configured to operate without supervision.

PREDICTING MOTOR FUNCTION SCORES IN POMPE DISEASE TREATMENT

Nº publicación: US20260311885A1 08/10/2026

Solicitante:

GENZYME CORP [US]
Genzyme Corporation

Resumen de: US20260311885A1

A prediction method for predicting a change in the motor function score from a baseline score. The system obtains input data including a temporal trajectory of an indicator metabolite compound for the subject. The determines a predicted temporal trajectory of the motor function score using a prediction model and the input data.